| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | secondary active transmembrane transporter activity | 3.70e-06 | 296 | 17 | 5 | GO:0015291 | |
| GeneOntologyMolecularFunction | active monoatomic ion transmembrane transporter activity | 4.02e-06 | 301 | 17 | 5 | GO:0022853 | |
| GeneOntologyMolecularFunction | potassium:chloride symporter activity | 2.45e-05 | 9 | 17 | 2 | GO:0015379 | |
| GeneOntologyMolecularFunction | metal ion transmembrane transporter activity | 3.29e-05 | 465 | 17 | 5 | GO:0046873 | |
| GeneOntologyMolecularFunction | active transmembrane transporter activity | 3.72e-05 | 477 | 17 | 5 | GO:0022804 | |
| GeneOntologyMolecularFunction | ammonium channel activity | 4.48e-05 | 12 | 17 | 2 | GO:0008519 | |
| GeneOntologyMolecularFunction | sodium:proton antiporter activity | 8.13e-05 | 16 | 17 | 2 | GO:0015385 | |
| GeneOntologyMolecularFunction | solute:monoatomic cation symporter activity | 1.32e-04 | 119 | 17 | 3 | GO:0015294 | |
| GeneOntologyMolecularFunction | inorganic cation transmembrane transporter activity | 1.36e-04 | 627 | 17 | 5 | GO:0022890 | |
| GeneOntologyMolecularFunction | chloride:monoatomic cation symporter activity | 1.71e-04 | 23 | 17 | 2 | GO:0015377 | |
| GeneOntologyMolecularFunction | monoatomic cation transmembrane transporter activity | 1.78e-04 | 664 | 17 | 5 | GO:0008324 | |
| GeneOntologyMolecularFunction | monoatomic anion:monoatomic cation symporter activity | 2.19e-04 | 26 | 17 | 2 | GO:0015296 | |
| GeneOntologyMolecularFunction | metal cation:proton antiporter activity | 2.36e-04 | 27 | 17 | 2 | GO:0051139 | |
| GeneOntologyMolecularFunction | symporter activity | 2.62e-04 | 150 | 17 | 3 | GO:0015293 | |
| GeneOntologyMolecularFunction | inorganic molecular entity transmembrane transporter activity | 3.29e-04 | 758 | 17 | 5 | GO:0015318 | |
| GeneOntologyMolecularFunction | sodium ion transmembrane transporter activity | 3.84e-04 | 171 | 17 | 3 | GO:0015081 | |
| GeneOntologyMolecularFunction | monoatomic ion transmembrane transporter activity | 4.05e-04 | 793 | 17 | 5 | GO:0015075 | |
| GeneOntologyMolecularFunction | transporter activity | 4.77e-04 | 1289 | 17 | 6 | GO:0005215 | |
| GeneOntologyMolecularFunction | metal cation:monoatomic cation antiporter activity | 6.04e-04 | 43 | 17 | 2 | GO:0140828 | |
| GeneOntologyMolecularFunction | transmembrane transporter activity | 2.43e-03 | 1180 | 17 | 5 | GO:0022857 | |
| GeneOntologyMolecularFunction | chloride transmembrane transporter activity | 4.97e-03 | 125 | 17 | 2 | GO:0015108 | |
| GeneOntologyMolecularFunction | antiporter activity | 6.02e-03 | 138 | 17 | 2 | GO:0015297 | |
| GeneOntologyMolecularFunction | monoatomic anion transmembrane transporter activity | 7.17e-03 | 151 | 17 | 2 | GO:0008509 | |
| GeneOntologyMolecularFunction | potassium ion transmembrane transporter activity | 8.71e-03 | 167 | 17 | 2 | GO:0015079 | |
| GeneOntologyMolecularFunction | inorganic anion transmembrane transporter activity | 9.11e-03 | 171 | 17 | 2 | GO:0015103 | |
| GeneOntologyMolecularFunction | proton transmembrane transporter activity | 1.09e-02 | 188 | 17 | 2 | GO:0015078 | |
| GeneOntologyBiologicalProcess | ammonium import across plasma membrane | 3.83e-06 | 4 | 17 | 2 | GO:0140157 | |
| GeneOntologyBiologicalProcess | ammonium transmembrane transport | 4.96e-05 | 13 | 17 | 2 | GO:0072488 | |
| GeneOntologyBiologicalProcess | chloride ion homeostasis | 1.90e-04 | 25 | 17 | 2 | GO:0055064 | |
| GeneOntologyBiologicalProcess | monoatomic anion homeostasis | 2.39e-04 | 28 | 17 | 2 | GO:0055081 | |
| GeneOntologyBiologicalProcess | potassium ion homeostasis | 4.19e-04 | 37 | 17 | 2 | GO:0055075 | |
| GeneOntologyBiologicalProcess | cell volume homeostasis | 5.40e-04 | 42 | 17 | 2 | GO:0006884 | |
| GeneOntologyBiologicalProcess | sodium ion transmembrane transport | 6.19e-04 | 208 | 17 | 3 | GO:0035725 | |
| GeneOntologyBiologicalProcess | inorganic cation transmembrane transport | 6.97e-04 | 922 | 17 | 5 | GO:0098662 | |
| GeneOntologyBiologicalProcess | monoatomic cation transmembrane transport | 7.68e-04 | 942 | 17 | 5 | GO:0098655 | |
| GeneOntologyBiologicalProcess | regulation of cell size | 7.78e-04 | 225 | 17 | 3 | GO:0008361 | |
| GeneOntologyBiologicalProcess | potassium ion import across plasma membrane | 7.96e-04 | 51 | 17 | 2 | GO:1990573 | |
| GeneOntologyBiologicalProcess | import across plasma membrane | 8.29e-04 | 230 | 17 | 3 | GO:0098739 | |
| GeneOntologyBiologicalProcess | respiratory system process | 9.25e-04 | 55 | 17 | 2 | GO:0003016 | |
| GeneOntologyBiologicalProcess | metal ion transport | 1.01e-03 | 1000 | 17 | 5 | GO:0030001 | |
| GeneOntologyBiologicalProcess | inorganic ion transmembrane transport | 1.09e-03 | 1017 | 17 | 5 | GO:0098660 | |
| GeneOntologyBiologicalProcess | sodium ion transport | 1.39e-03 | 275 | 17 | 3 | GO:0006814 | |
| GeneOntologyBiologicalProcess | monoatomic ion transmembrane transport | 1.64e-03 | 1115 | 17 | 5 | GO:0034220 | |
| GeneOntologyBiologicalProcess | monoatomic cation transport | 1.93e-03 | 1157 | 17 | 5 | GO:0006812 | |
| GeneOntologyBiologicalProcess | respiratory gaseous exchange by respiratory system | 2.62e-03 | 93 | 17 | 2 | GO:0007585 | |
| Domain | KCL_cotranspt | 4.12e-06 | 4 | 16 | 2 | IPR000076 | |
| Domain | SLC12A_fam | 1.44e-05 | 7 | 16 | 2 | IPR004842 | |
| Domain | SLC12_C | 1.92e-05 | 8 | 16 | 2 | IPR018491 | |
| Domain | SLC12 | 1.92e-05 | 8 | 16 | 2 | PF03522 | |
| Domain | AA-permease/SLC12A_dom | 1.57e-04 | 22 | 16 | 2 | IPR004841 | |
| Domain | AA_permease | 1.57e-04 | 22 | 16 | 2 | PF00324 | |
| Pathway | REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS | 1.16e-05 | 7 | 11 | 2 | M27339 | |
| Pathway | REACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS | 1.16e-05 | 7 | 11 | 2 | MM15081 | |
| Pathway | REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 2.38e-05 | 238 | 11 | 4 | MM15076 | |
| Pathway | REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 2.84e-05 | 249 | 11 | 4 | M5988 | |
| Pathway | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | 6.90e-05 | 108 | 11 | 3 | M823 | |
| Pathway | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | 7.09e-05 | 109 | 11 | 3 | MM15074 | |
| Pathway | REACTOME_TRANSPORT_OF_SMALL_MOLECULES | 9.39e-05 | 681 | 11 | 5 | MM14985 | |
| Pathway | REACTOME_TRANSPORT_OF_SMALL_MOLECULES | 1.36e-04 | 736 | 11 | 5 | M27287 | |
| Pubmed | 6.74e-07 | 3 | 17 | 2 | 11551954 | ||
| Pubmed | K-Cl cotransporter gene expression during human and murine erythroid differentiation. | 6.74e-07 | 3 | 17 | 2 | 21733850 | |
| Pubmed | 6.74e-07 | 3 | 17 | 2 | 15262997 | ||
| Pubmed | 1.35e-06 | 4 | 17 | 2 | 12637262 | ||
| Pubmed | 6.29e-06 | 8 | 17 | 2 | 11395011 | ||
| Pubmed | The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. | 6.29e-06 | 8 | 17 | 2 | 24393035 | |
| Pubmed | Similar effects of all WNK3 variants on SLC12 cotransporters. | 6.29e-06 | 8 | 17 | 2 | 21613606 | |
| Pubmed | 6.29e-06 | 8 | 17 | 2 | 12386165 | ||
| Pubmed | 8.08e-06 | 9 | 17 | 2 | 19323993 | ||
| Pubmed | Rare independent mutations in renal salt handling genes contribute to blood pressure variation. | 5.16e-05 | 22 | 17 | 2 | 18391953 | |
| Pubmed | 1.41e-04 | 568 | 17 | 4 | 37774976 | ||
| Pubmed | 1.56e-04 | 38 | 17 | 2 | 32541003 | ||
| Pubmed | Protein Binder Toolbox for Studies of Solute Carrier Transporters. | 3.41e-04 | 56 | 17 | 2 | 38878854 | |
| Pubmed | Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. | 3.79e-04 | 59 | 17 | 2 | 23754746 | |
| Interaction | ANGPTL2 interactions | 2.12e-05 | 9 | 16 | 2 | int:ANGPTL2 | |
| Interaction | CLRN2 interactions | 2.79e-05 | 76 | 16 | 3 | int:CLRN2 | |
| GeneFamily | Solute carriers | 5.41e-06 | 395 | 13 | 5 | 752 | |
| Coexpression | GSE33374_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_DN | 7.24e-06 | 200 | 17 | 4 | M8533 | |
| Computational | Neighborhood of PTPN9 | 3.44e-06 | 61 | 6 | 3 | MORF_PTPN9 | |
| Computational | Neighborhood of ORC1L | 4.99e-06 | 69 | 6 | 3 | MORF_ORC1L | |
| Computational | Neighborhood of RBM8A | 9.38e-06 | 85 | 6 | 3 | MORF_RBM8A | |
| Computational | Neighborhood of CASP2 | 1.67e-05 | 103 | 6 | 3 | MORF_CASP2 | |
| Computational | Neighborhood of CNTN1 | 1.93e-05 | 108 | 6 | 3 | MORF_CNTN1 | |
| Computational | Neighborhood of IKBKG | 3.94e-05 | 137 | 6 | 3 | MORF_IKBKG | |
| Computational | Neighborhood of MYST2 | 5.82e-04 | 68 | 6 | 2 | MORF_MYST2 | |
| Computational | Neighborhood of PDPK1 | 6.89e-04 | 74 | 6 | 2 | MORF_PDPK1 | |
| Computational | Neighborhood of ARAF1 | 7.65e-04 | 78 | 6 | 2 | MORF_ARAF1 | |
| Computational | Neighborhood of PHB | 1.95e-03 | 125 | 6 | 2 | MORF_PHB | |
| Computational | Neighborhood of PML | 2.62e-03 | 145 | 6 | 2 | MORF_PML | |
| Computational | Neighborhood of RAGE | 2.72e-03 | 148 | 6 | 2 | MORF_RAGE | |
| Computational | Neighborhood of DDX11 | 3.02e-03 | 156 | 6 | 2 | MORF_DDX11 | |
| Computational | Neighborhood of FANCG | 3.45e-03 | 167 | 6 | 2 | MORF_FANCG | |
| Computational | Neighborhood of RPA2 | 4.59e-03 | 193 | 6 | 2 | MORF_RPA2 | |
| Computational | Neighborhood of FDXR | 6.24e-03 | 226 | 6 | 2 | MORF_FDXR | |
| Drug | ((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid | 5.25e-07 | 2 | 17 | 2 | ctd:C095651 | |
| Drug | Trichlormethiazide | 5.24e-06 | 5 | 17 | 2 | ctd:D014237 | |
| Drug | Potassium Chloride | 7.86e-06 | 6 | 17 | 2 | DB00761 | |
| Drug | Bumetanide | 6.26e-05 | 16 | 17 | 2 | ctd:D002034 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| QRKYLKIMPVHLLML | 566 | Q0P6H9 | |
| KIMPVHLLMLLLYIW | 571 | Q0P6H9 | |
| IYLPHVMLLAKIKMR | 2546 | Q96N23 | |
| MKPLLETLYLLGMLV | 1 | Q8IVL8 | |
| HPLKYRMLIGMVDVI | 231 | A6NHQ2 | |
| ILIYLLPVKMLLGHM | 251 | Q5JVF3 | |
| GMLMLLPFLLRQHKV | 856 | Q9Y666 | |
| IPKPMMQHYISLLLK | 1536 | Q8NEY1 | |
| IILPLALMKHLGYLG | 181 | Q8WUX1 | |
| GMLMLLPFLLRQHKV | 856 | Q9UP95 | |
| MLIKEYHILLPMSLD | 1 | O00562 | |
| SILASYLKMLPMGLI | 301 | A0PJK1 | |
| LMVPMQRVLKYHLLL | 326 | P15498 | |
| LPMILALHLKRFKYM | 251 | O75317 | |
| LLMGILGPKMLTRHY | 486 | Q4ZJI4 | |
| LLHLMYTGKMAPQLI | 76 | Q8N680 | |
| YPTISMVKPLLHMLL | 416 | O96006 | |
| PMTGLLLMILSLIYV | 186 | Q99608 |