Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EGF_LAM_2	LAMB2 CELSR2 MEGF8	3.83e-05	30	41	3	PS50027
Domain	EGF_LAM_1	LAMB2 CELSR2 MEGF8	3.83e-05	30	41	3	PS01248
Domain	Laminin_EGF	LAMB2 CELSR2 MEGF8	6.12e-05	35	41	3	PF00053
Domain	EGF_Lam	LAMB2 CELSR2 MEGF8	6.12e-05	35	41	3	SM00180
Domain	Laminin_EGF	LAMB2 CELSR2 MEGF8	7.85e-05	38	41	3	IPR002049
Domain	EGF_1	NRG2 LAMB2 ASTN2 CELSR2 MEGF8	2.29e-04	255	41	5	PS00022
Domain	EGF_2	NRG2 LAMB2 ASTN2 CELSR2 MEGF8	2.73e-04	265	41	5	PS01186
Domain	EGF_3	NRG2 ASTN2 CELSR2 MEGF8	1.72e-03	235	41	4	PS50026
Domain	EGF	NRG2 LAMB2 CELSR2 MEGF8	1.72e-03	235	41	4	SM00181
Domain	FYVE	FGD1 ZFYVE19	1.84e-03	29	41	2	PF01363
Domain	FYVE	FGD1 ZFYVE19	1.84e-03	29	41	2	SM00064
Domain	EGF-like_dom	NRG2 LAMB2 CELSR2 MEGF8	2.12e-03	249	41	4	IPR000742
Domain	Plexin_repeat	SEMA6B MEGF8	2.24e-03	32	41	2	IPR002165
Domain	PSI	SEMA6B MEGF8	2.24e-03	32	41	2	PF01437
Domain	EGF-like_CS	NRG2 LAMB2 CELSR2 MEGF8	2.51e-03	261	41	4	IPR013032
Domain	Znf_FYVE-rel	FGD1 ZFYVE19	2.52e-03	34	41	2	IPR017455
Domain	Znf_FYVE	FGD1 ZFYVE19	3.14e-03	38	41	2	IPR000306
Domain	ZF_FYVE	FGD1 ZFYVE19	3.48e-03	40	41	2	PS50178
Domain	PSI	SEMA6B MEGF8	4.20e-03	44	41	2	IPR016201
Domain	PSI	SEMA6B MEGF8	4.58e-03	46	41	2	SM00423
Domain	Growth_fac_rcpt_	LAMB2 CELSR2 MEGF8	4.83e-03	156	41	3	IPR009030
Domain	Gal_Oxase/kelch_b-propeller	KLHL8 MEGF8	7.43e-03	59	41	2	IPR011043
Pubmed	Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells.	CDKN2A WNT9A	4.91e-06	3	45	2	29440280
Pubmed	Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.	CDKN2A CELSR2	3.42e-05	7	45	2	21239051
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	NRG2 SLC6A11 ASTN2 ALDH5A1 SLC1A4	4.25e-05	300	45	5	19086053
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR2 MEGF8	5.86e-05	9	45	2	9693030
Pubmed	Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.	CDKN2A CELSR2	1.94e-04	16	45	2	19198609
Pubmed	A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.	CDKN2A CELSR2	2.47e-04	18	45	2	20971364
Pubmed	TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.	TRIM65 MEFV	2.76e-04	19	45	2	26347139
Pubmed	Additive effect of multiple genetic variants on the risk of coronary artery disease.	CDKN2A CELSR2	2.76e-04	19	45	2	20738937
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	CDKN2A WEE1	5.63e-04	27	45	2	36899856
Pubmed	Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.	ASTN2 NT5DC3	6.06e-04	28	45	2	18839057
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	CELSR2 WNT9A	9.48e-04	35	45	2	30940800
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	FGD1 PLEKHG2	1.12e-03	38	45	2	11756498
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD1 ZFYVE19	1.28e-03	31	31	2	81
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD1 PLEKHG2	5.70e-03	66	31	2	722
Disease	Congenital neurologic anomalies	FGD1 L2HGDH	9.27e-05	10	43	2	C0497552
Disease	Cranioschisis	FGD1 L2HGDH	9.27e-05	10	43	2	C0265541
Disease	myelodysplastic syndrome (is_implicated_in)	CDKN2A MEFV	8.79e-04	30	43	2	DOID:0050908 (is_implicated_in)
Disease	Agents acting on the renin-angiotensin system use measurement	ZNF318 CELSR2 PRDM6 WNT9A	1.42e-03	335	43	4	EFO_0009931
Disease	coronary artery disease	TBXAS1 LAMB2 ASTN2 TRIM65 CELSR2 ALDH5A1 PRDM6	1.57e-03	1194	43	7	EFO_0001645

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGCPRGRAAGADPAQ	C1orf167	1366	Q5SNV9
PGSSGRRGRPRASCG	C20orf204	76	A0A1B0GTL2
GGPGRVAPLCAAAGR	AJM1	156	C9J069
AAPGRGAAGRARCLG	CDKN2A	111	Q8N726
GAAGRARCLGPSARG	CDKN2A	116	Q8N726
PCGPHGRCRSREGGY	CELSR2	1296	Q9HCU4
GTGPRRARGCLGAAG	DENND6B	6	Q8NEG7
GPGSGLRGRPRLCFH	ASTN2	11	O75129
AGCRRASGFPALGRG	ZFYVE19	16	Q96K21
GGDSGFGPHCRRLGR	MXD4	191	Q14582
ACGRARGLFAGGSPG	L2HGDH	11	Q9H9P8
GGSPGACGFASGRPR	L2HGDH	21	Q9H9P8
ACGFASGRPRPLCGG	L2HGDH	26	Q9H9P8
PSALPRGGRAARAGG	ARTN	96	Q5T4W7
GPARRGCDSAPGPAR	EZHIP	276	Q86X51
GCDSAPGPARRGRDS	EZHIP	281	Q86X51
FCVGGRGGSGDPFRS	KLHL8	321	Q9P2G9
RSRCGPSLGSGRGGP	PTGER2	231	P43116
AAGPGPRRGTCALGG	NRG2	681	O14511
PGSFGNATGSRGCRP	MEGF8	1196	Q7Z7M0
NAGYRGPDRAGRTPC	LCA10	86	Q71F78
GHFGDPSRPGGRCQL	LAMB2	971	P55268
GPRPYGGGAASLRCS	MEFV	131	O15553
PRRRGACGSRGGNFP	PMS2P1	176	A4D2B8
ACGSRGGNFPSPRGG	PMS2P1	181	A4D2B8
SRCGAGGARGASLPP	ECEL1	21	O95672
GGGEGRGAPRFRCSA	PRDM6	156	Q9NQX0
GGAASRRGAGRPCPF	GSC2	6	O15499
RPRSRPGSGGGGCCV	C2CD4D	246	B7Z1M9
APGLGPRAVCRGGSR	CXorf38	51	Q8TB03
GSTFPGCRLRPRAGG	ALDH5A1	16	P51649
AALRGGCGTAARGRP	NT5DC3	21	Q86UY8
GCGTAARGRPCAGPA	NT5DC3	26	Q86UY8
SAPAGGGGARAPRSR	PPP1R3E	66	Q9H7J1
LGRAGRGDTFCPGPT	FGD1	916	P98174
ASGCARGPGPGVGAR	AGMAT	6	Q9BSE5
APGGCEGRGAPVSFR	NOM1	61	Q5C9Z4
ADAAGPGCPRCRARG	RNF169	96	Q8NCN4
YRPDRCGRPGGGETG	SEMA6B	481	Q9H3T3
PFGAGPRSCLGVRLG	TBXAS1	471	P24557
PGDASPRGCGARRAG	WEE1	146	P30291
PSRRRGCGLAPAGAA	TMTC1	16	Q8IUR5
GPGAPGTAAGRARRC	SLC1A4	21	P43007
GGCSSGGAAPARHPR	SLC6A11	26	P48066
ACRPGPRAGGAAAAA	ZSWIM6	41	Q9HCJ5
RGRASGAGGSDPLPR	WNT9A	271	O14904
ARRQGPGGGAPAASR	PLEKHG2	1291	Q9H7P9
AFGPRRGSSPRGAAG	TRPC6	6	Q9Y210
QRPRSGGARGSFAPG	TMEM160	26	Q9NX00
CRQSRGPGGPGSFEL	TRIM65	356	Q6PJ69
PGPAGFRGSSRGESR	ZNF318	101	Q5VUA4
GPGLGPRARRAGSCD	ZAR1	91	Q86SH2