Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmyosin light chain kinase activity

MYLK3 MYLK4

1.17e-044892GO:0004687
GeneOntologyCellularComponentextrinsic component of external side of plasma membrane

CUBN PCSK9

1.02e-044872GO:0031232
GeneOntologyCellularComponentequatorial microtubule organizing center

TUBGCP6 TUBGCP3

1.70e-045872GO:0000923
Domain-

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

2.86e-0667987143.30.160.60
Domainzf-C2H2

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

3.63e-066938714PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

3.69e-066948714IPR013087
DomainZINC_FINGER_C2H2_2

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

1.30e-057758714PS50157
DomainZINC_FINGER_C2H2_1

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

1.33e-057778714PS00028
Domainzf-C2H2_6

ZNF787 ZBTB49 ZNF141 ZNF780A ZNF500 ZNF227 ZKSCAN5 ZBTB24 ZNF646

1.55e-05314879PF13912
DomainZnf_C2H2-like

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

1.75e-057968714IPR015880
DomainZnf_C2H2

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

1.98e-058058714IPR007087
DomainZnF_C2H2

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

2.06e-058088714SM00355
DomainGCP

TUBGCP6 TUBGCP3

2.13e-045872IPR007259
DomainGuanine_nucleotide-bd_bsu

GNB4 GNB2

2.13e-045872IPR016346
DomainSpc97_Spc98

TUBGCP6 TUBGCP3

2.13e-045872PF04130
DomainVDCC_a1su_IQ

CACNA1B CACNA1C

4.44e-047872IPR014873
DomainGPHH

CACNA1B CACNA1C

4.44e-047872PF16905
DomainGPHH_dom

CACNA1B CACNA1C

4.44e-047872IPR031649
DomainCa_chan_IQ

CACNA1B CACNA1C

4.44e-047872SM01062
DomainCa_chan_IQ

CACNA1B CACNA1C

4.44e-047872PF08763
DomainPectin_lyase_fold/virulence

FBXO11 CEMIP2

5.90e-048872IPR011050
DomainGprotein_B

GNB4 GNB2

9.42e-0410872IPR001632
DomainVDCCAlpha1

CACNA1B CACNA1C

9.42e-0410872IPR002077
DomainPTBI

IRS4 DOK3

1.15e-0311872SM00310
DomainIRS_PTB

IRS4 DOK3

1.37e-0312872PS51064
DomainKRAB

ZNF141 ZNF780A ZKSCAN3 ZNF500 ZNF101 ZNF227 ZKSCAN5

1.41e-03358877PS50805
DomainKRAB

ZNF141 ZNF780A ZKSCAN3 ZNF500 ZNF101 ZNF227 ZKSCAN5

1.41e-03358877PF01352
DomainKRAB

ZNF141 ZNF780A ZKSCAN3 ZNF500 ZNF101 ZNF227 ZKSCAN5

1.67e-03369877SM00349
DomainKRAB

ZNF141 ZNF780A ZKSCAN3 ZNF500 ZNF101 ZNF227 ZKSCAN5

1.70e-03370877IPR001909
DomainIRS_PTB

IRS4 DOK3

1.88e-0314872IPR002404
DomainIRS

IRS4 DOK3

1.88e-0314872PF02174
DomainSCAN

ZKSCAN3 ZNF500 ZKSCAN5

2.26e-0356873SM00431
DomainAT_hook

KMT2C ZBTB24

2.47e-0316872PF02178
DomainSCAN_BOX

ZKSCAN3 ZNF500 ZKSCAN5

2.50e-0358873PS50804
DomainSCAN

ZKSCAN3 ZNF500 ZKSCAN5

2.50e-0358873PF02023
DomainSCAN_dom

ZKSCAN3 ZNF500 ZKSCAN5

2.50e-0358873IPR003309
DomainRetrov_capsid_C

ZKSCAN3 ZNF500 ZKSCAN5

2.63e-0359873IPR008916
DomainCa/CaM-dep_Ca-dep_prot_Kinase

MYLK3 MYLK4 MAPKAPK3

4.10e-0369873IPR020636
DomainFG_GAP

ITGA6 CRTAC1

4.66e-0322872PS51470
DomainCupredoxin

EFNA2 PADI3

4.66e-0322872IPR008972
DomainFG-GAP

ITGA6 CRTAC1

5.54e-0324872PF01839
DomainFG-GAP

ITGA6 CRTAC1

5.54e-0324872IPR013517
DomainRicin_B_lectin

MRC2 GALNT13

6.00e-0325872PF00652
Domain-

B4GALNT4 CMAS GALNT13

6.41e-03818733.90.550.10
DomainAT_hook

KMT2C ZBTB24

6.98e-0327872SM00384
DomainAT_hook_DNA-bd_motif

KMT2C ZBTB24

6.98e-0327872IPR017956
DomainG-protein_beta_WD-40_rep

GNB4 GNB2 CORO7

7.32e-0385873IPR020472
DomainRICIN

MRC2 GALNT13

7.49e-0328872SM00458
DomainRICIN_B_LECTIN

MRC2 GALNT13

7.49e-0328872PS50231
DomainNucleotide-diphossugar_trans

B4GALNT4 CMAS GALNT13

8.06e-0388873IPR029044
DomainRicin_B_lectin

MRC2 GALNT13

8.57e-0330872IPR000772
DomainPkinase

TTBK2 TTBK1 MYLK3 GUCY2F MYLK4 MAPKAPK3

8.75e-03381876PF00069
DomainHMGI/Y_DNA-bd_CS

KMT2C ZBTB24

9.14e-0331872IPR000637
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

DPAGT1 TTBK2 KMT2C RIPOR2 ZNF780A RXFP2 AKNAD1 ZBTB40 FBXO11 DGKZ ZNF101 PFKL CUBN LCMT2 ZBTB24 TIAM2

1.49e-081084891611544199
Pubmed

Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.

ALDH4A1 GNB2 ZFP36

3.22e-07689314679154
Pubmed

Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities.

MYLK3 MYLK4

6.48e-06289227325775
Pubmed

Inactivation of tristetraprolin in chronic hypoxia provokes the expression of cathepsin B.

CTSB ZFP36

6.48e-06289225452305
Pubmed

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.

TTBK2 TTBK1

6.48e-06289229409526
Pubmed

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.

CACNA1B CACNA1C

6.48e-06289222590648
Pubmed

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.

TTBK2 TTBK1

6.48e-06289232424773
Pubmed

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis.

TTBK2 TTBK1

6.48e-06289237059819
Pubmed

Molecular interaction between cyclophilin D and adenine nucleotide translocase in cytochrome c release: does it determine whether cytochrome c release is dependent on permeability transition or not?

SLC25A4 PPID

6.48e-06289215033717
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TUBGCP6 KMT2C UBE2O MRC2 CASKIN1 ADGRA2 TIAM2 CEMIP2 ZNF646

8.80e-0652989914621295
Pubmed

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.

UBE2O DIS3L MTHFD1L DOK3 DDX23 PFKL LCMT2 PALB2

1.53e-0543189833660365
Pubmed

Cyclophilin D, a component of the permeability transition-pore, is an apoptosis repressor.

SLC25A4 PPID

1.94e-05389214729611
Pubmed

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

TTBK2 TTBK1

1.94e-05389216923168
Pubmed

Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues.

GNB4 GNB2

1.94e-05389210409705
Pubmed

Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore.

SLC25A4 PPID

1.94e-05389212149099
Pubmed

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

TTBK2 TTBK1

1.94e-05389225473830
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1B CACNA1C

1.94e-05389226507659
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1B CACNA1C

3.87e-05489215728831
Pubmed

Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.

GNB4 GNB2

3.87e-0548921543505
Pubmed

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.

CACNA1B CACNA1C

3.87e-05489219065143
Pubmed

The role of G protein beta subunits in the release of ATP from human erythrocytes.

GNB4 GNB2

3.87e-05489212512701
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1B CACNA1C

3.87e-05489215953418
Pubmed

GCP5 and GCP6: two new members of the human gamma-tubulin complex.

TUBGCP6 TUBGCP3

6.44e-05589211694571
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1B CACNA1C

6.44e-05589216787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1B CACNA1C

6.44e-05589215451373
Pubmed

Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration.

SLC25A4 PPID

6.44e-05589221958963
Pubmed

Comparative analysis of cobalamin binding kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin.

TCN2 CUBN

6.44e-05589211788601
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1B CACNA1C

6.44e-05589211296258
Pubmed

The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3.

MAPKAPK3 ZFP36

6.44e-05589231527197
Pubmed

Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis.

SLC25A4 PPID

6.44e-05589216507998
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

UBE2O ABCF1 SLC25A4 BCAS3 CASKIN1 DPYSL5 DHX57 DGKZ PFKL GNB2 CORO7 CMAS HSPA4

7.03e-051431891337142655
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

ZNF787 UBE2O ABCF1 IRS4 DHX57 CMAS PPID HSPA4

8.23e-0554789837267103
Pubmed

Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.

CACNA1B CACNA1C

9.65e-05689216029198
Pubmed

A genome-wide association study identifies susceptibility loci for Wilms tumor.

TCN2 PCSK9

9.65e-05689222544364
Pubmed

Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.

GNB4 GNB2

9.65e-05689216371464
Pubmed

Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.

GNB4 GNB2

9.65e-05689216884933
Pubmed

Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.

CACNA1B CACNA1C

9.65e-05689211438518
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1B GNB2

9.65e-0568929238069
Pubmed

Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

HSPA4 ZFP36

9.65e-05689220221403
Pubmed

Mitochondrial Raf1 Regulates Glutamine Catabolism.

MIPEP DGKZ GNB2 CTSB PPID CEMIP2

1.00e-0428889638496616
Pubmed

Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.

ZNF787 TTBK2 IRS4

1.09e-043689315717329
Pubmed

Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.

CACNA1B CACNA1C

1.35e-04789221057379
Pubmed

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1.

DOK3 GNB2

1.35e-04789233512474
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

KMT2C TUBGCP3 MAPKAPK3 MIPEP DGKZ ZNF227 GNB2 CTSB PPID ZKSCAN5 TIAM2

1.40e-041124891121900206
Pubmed

The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.

TUBGCP6 TUBGCP3

1.79e-04889224509916
Pubmed

TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.

TTBK2 TTBK1

1.79e-04889226323690
Pubmed

The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.

GNB4 GNB2

1.79e-0488922328987
Pubmed

Quantitative assessment of complex formation of nuclear-receptor accessory proteins.

PPID HSPA4

1.79e-04889210642522
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

CACNA1B KMT2C RIPOR2 IRS4 GNB4 GNB2

1.83e-0432289626514267
Pubmed

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB.

ITGA6 GNB2 CEMIP2

1.99e-044489330024968
Pubmed

Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.

GNB4 GNB2

2.30e-04989210339615
Pubmed

Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.

TUBGCP6 TUBGCP3

2.30e-04989211956313
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1B CACNA1C

2.30e-04989216382099
Pubmed

Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.

TUBGCP6 TUBGCP3

2.30e-0498928838651
Pubmed

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.

PPID HSPA4

2.30e-04989215004035
Pubmed

Identification of NPM-ALK interacting proteins by tandem mass spectrometry.

IRS4 CASKIN1 PPID

2.42e-044789314968112
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

CACNA1B ABCF1 DOK3 ZNF500 DGKZ CFP PALB2 CUEDC1 ZNF646

2.83e-0483289936724073
Pubmed

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.

PPID HSPA4

2.88e-04108929222609
Pubmed

Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.

GNB4 GNB2

2.88e-041089228334111
Pubmed

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.

KMT2C FBXO11

2.88e-041089222421440
Pubmed

Expression of olfactory receptors, G-proteins and AxCAMs during the development and maturation of olfactory sensory neurons in the mouse.

GNB4 GNB2

2.88e-04108929733924
Pubmed

CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex.

TUBGCP6 TUBGCP3

2.88e-041089221135143
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CACNA1C KMT2C ABCF1 MTHFD1L DPYSL5 DDX23 DHX57

2.93e-0449789736774506
Pubmed

The G protein subunit gene families.

GNB4 GNB2

3.51e-041189210644457
Pubmed

Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α2a-adrenergic receptors.

GNB4 GNB2

3.51e-041189234932372
Pubmed

A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.

GNB4 GNB2

3.51e-041189225982117
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

SLC25A4 MRC2 MIPEP ITGA6 GNB4 ALDH4A1 GNB2 CTSB HSPA4

3.58e-0485989931536960
Pubmed

Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein β-Subunit Ubiquitination and Downstream Signaling.

GNB4 GNB2

4.20e-041289234342229
Pubmed

Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.

GNB4 GNB2

4.20e-041289220186915
Pubmed

BCAS3 exhibits oncogenic properties by promoting CRL4A-mediated ubiquitination of p53 in breast cancer.

BCAS3 HSPA4

4.20e-041289234240781
Pubmed

Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.

QRFP IRS4

4.20e-041289231375626
Pubmed

Insulin receptor substrate 4 associates with the protein IRAS.

IRS4 HSPA4

4.20e-041289211912194
Pubmed

Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.

TCN2 CUBN

4.20e-041289220852008
Pubmed

Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.

GNB4 GNB2

4.20e-041289216301321
Pubmed

Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.

GNB4 GNB2

4.20e-04128928636150
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

UBE2O ABCF1 DIS3L FBXO11 CRTAC1 ZNF227 CMAS CTSB ZKSCAN5 ZFP36 CUEDC1

4.38e-041285891135914814
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2C HSPA4

4.96e-041389221502505
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2C B4GALNT4 ZNF276 EFNA2 BCAS3 MTHFD1L CASKIN1 ZNF500 ADGRA2 TIAM2

5.28e-041105891035748872
Pubmed

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.

ABCF1 GNB4 CUBN GNB2 HSPA4

5.50e-042598959811942
Pubmed

ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.

ZBTB49 ZBTB40 ZBTB24

5.76e-046389334351428
Pubmed

Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

CNKSR3 ZNF646

5.78e-041489222451204
Pubmed

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.

IRS4 HSPA4

5.78e-041489221151955
Pubmed

Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.

IRS4 SLC25A4 PFKL

6.03e-046489322865885
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1B CACNA1C

6.65e-041589220188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1B CACNA1C

6.65e-041589224453333
Pubmed

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.

GNB4 GNB2

6.65e-041589212486123
Pubmed

Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors.

PPID HSPA4

6.65e-041589220661446
Pubmed

A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.

TCN2 CUBN

6.65e-041589220615890
Pubmed

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

PIGR METRNL DDX23 PFKL GNB2 CTSB

7.21e-0441789619199708
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

DPAGT1 UBE2O ABCF1 MTHFD1L MRC2 ITGA6 PFKL CMAS CTSB PPID HSPA4

7.32e-041367891132687490
Pubmed

Armc5 deletion causes developmental defects and compromises T-cell immune responses.

RIPOR2 ZBTB40

8.59e-041789228169274
Pubmed

Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.

GNB4 GNB2

8.59e-041789219376773
Pubmed

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

IRS4 SLC25A4 GNB4 GNB2 HSPA4

8.85e-0428889531501420
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

TUBGCP6 SLC25A4 MTHFD1L CNKSR3 DDX23 GNB2 CTSB

9.46e-0460689736538041
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS15 CFP CUBN

9.57e-047589320637190
Pubmed

Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.

EFNA2 ITGA6

9.65e-041889222243746
Pubmed

Additive effect of multiple genetic variants on the risk of coronary artery disease.

MTHFD1L PCSK9

1.08e-031989220738937
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF780A ZNF101 ZNF227 ZNF697

1.23e-0318189437372979
Pubmed

Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.

DDX23 PFKL

1.32e-032189212840015
Pubmed

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

ZBTB49 SULT2B1 BCAS3 DOK3 MAPKAPK3 DPYSL5 FBXO11 CRTAC1 ZNF227 ZBTB24 ZNF646

1.37e-031477891131515488
Cytoband6q25.2

CNKSR3 TIAM2

3.33e-04148926q25.2
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF787 ZBTB49 ZNF141 ZNF276 ZNF780A ZKSCAN3 ZNF500 ZBTB40 ZNF101 ZNF227 ZKSCAN5 ZBTB24 ZNF697 ZNF646

6.81e-08718601428
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SLC25A4 SULT2B1 PIGR MIPEP DHX57 CRTAC1

1.08e-06167896dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCelldroplet-Lung-nan-21m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY2F METRNL DOK3 CTSB ZFP36 TIAM2

1.28e-0617289651bea97564a33f0060c546c9be4bf8bf8f1660f6
ToppCelldroplet-Lung-nan-21m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GUCY2F METRNL DOK3 CTSB ZFP36 TIAM2

1.28e-06172896be4dd4ba8d7a651677c797c25fd75f14e627415a
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid-macrophage|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METRNL AKNAD1 DGKZ CFP NYX

1.40e-051538954b999892fb797e9f0d391630094f466463299d57
ToppCelldroplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METRNL DOK3 CTSB ZFP36 TIAM2

1.40e-051538956dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METRNL AKNAD1 DGKZ CFP NYX

1.40e-05153895e426db29e4ba83e7930dc88c74fc975b177c9540
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METRNL AKNAD1 DGKZ CFP NYX

1.40e-05153895668eacd76aad6054bd7d57e3af0b122c2443465f
ToppCelldroplet-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METRNL DOK3 CTSB ZFP36 TIAM2

1.40e-05153895f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|368C / Donor, Lineage, Cell class and subclass (all cells)

SULT2B1 MIPEP DHX57 CRTAC1 ZNF697

1.54e-0515689525b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MMS22L MYLK3 MYLK4 CUBN ZBTB24

2.08e-05166895f4698fd08965936d51695d571bd10fb77330d916
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

SLC25A4 SULT2B1 PIGR MIPEP CRTAC1

2.33e-051708954a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

METRNL DOK3 CTSB ZFP36 TIAM2

2.40e-0517189500739085fdbc4d64c9faacba2c2adeab580dd2b1
ToppCelldroplet-Lung-21m-Hematologic-myeloid|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

METRNL DOK3 CFP CTSB ZFP36

2.40e-0517189522ad6de44e1d3f72a3d78d46fd26a5743a4f84a5
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

MMS22L MYLK3 MYLK4 CUBN ZBTB24

2.47e-05172895e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCelldroplet-Lung-1m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

METRNL DOK3 CTSB ZFP36 TIAM2

2.47e-051728955f58ff6cac32546d07b2a49ed250b6c7aa417188
ToppCellEndothelial-Endothelial-C|Endothelial / shred on cell class and cell subclass (v4)

RIPOR2 ITGA6 DHX57 ATP13A3 CEMIP2

2.83e-05177895b5b9278dfd76b1aacd88e5fe86e91a2c9b565f87
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

QRFP B4GALNT4 ADGRG1 GNB4 CUEDC1

2.91e-05178895cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCelldroplet-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN2 ITGA6 ALDH4A1 CUBN CTSB

3.40e-05184895e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBGCP6 ZBTB49 CNKSR3 ITGA6 CEMIP2

3.49e-05185895bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF787 TCN2 CORO7 LCMT2 ZFP36

3.68e-051878953699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF787 TCN2 CORO7 LCMT2 ZFP36

3.68e-05187895033ba52c0c2f9978784947098fa697368ae44834
ToppCell(2)_Fibroblasts-(21)_Fibro-2|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

TCN2 METRNL MRC2 ITGA6 GNB4

3.97e-05190895d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell(2)_Fibroblasts-(21)_Fibro-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

METRNL MRC2 TMEM179 ITGA6 PADI3

4.07e-051918955ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FBXO11 ATP13A3 HSPA4 ZFP36 CEMIP2

4.17e-051928956bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCell390C-Myeloid-Monocyte-CD14+_Monocyte|390C / Donor, Lineage, Cell class and subclass (all cells)

METRNL DOK3 CFP ATP13A3 CTSB

4.27e-05193895a50ee6110ea272d9d9f41d48bb5d43711cc00a32
ToppCellCV-Moderate-6|Moderate / Virus stimulation, Condition and Cluster

KMT2C ABCF1 MAPKAPK3 ADGRG1 CTSB

4.49e-051958952b8a72d7e755b9655c7a496000d10ff06e50862b
ToppCellsevere_COVID-19-NK|severe_COVID-19 / disease group, cell group and cell class (v2)

ZNF276 METRNL ADGRG1 DGKZ CEMIP2

4.83e-051988957f51e37516f717e424190e6584f1c74d357e2da4
ToppCellLPS_only-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS_only / Treatment groups by lineage, cell group, cell type

RIPOR2 METRNL MAPKAPK3 CFP CTSB

4.83e-051988952985c80e656e483866c696fa08c38af90311cd66
ToppCellLPS_only-Hematopoietic_Myeloid-Monocytes,_Macrophages|LPS_only / Treatment groups by lineage, cell group, cell type

RIPOR2 METRNL MAPKAPK3 CFP CTSB

4.83e-051988955d48539999d7a17f4165f612bf68be26c085e501
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOK3 TRPV2 GNB4 CTSB ZNF697

4.83e-051988959a77038e5db0ea757fd7ebcab294785b166ddc12
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCN2 METRNL MAPKAPK3 CFP CUEDC1

4.83e-05198895e2038d9239e23d670d539f1c58475fd0de028e51
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCN2 METRNL CFP GNB4 CTSB

4.94e-0519989518b6087863fda22e3e2a2167e7daeb347df1d95b
ToppCellSigmoid-(6)_Macrophage-(61)_LYVE1_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

METRNL CFP GNB4 CTSB CUEDC1

5.06e-05200895bc0280d52e4edc2c5edf4ead164a1c7cf3fccd60
ToppCellSigmoid-Macrophage-LYVE1_Macrophage|Sigmoid / Region, Cell class and subclass

METRNL CFP GNB4 CTSB CUEDC1

5.06e-05200895851a1b372ddbec522829069e69ed36a1f4832131
ToppCellControl-Neu_0|World / 5 Neutrophil clusters in COVID-19 patients

RIPOR2 EFNA2 ZKSCAN3 CUEDC1

9.86e-05120894840d0ac995e2fa41996514753e4e03c4aa4a26d0
DiseaseColorectal Carcinoma

DPAGT1 KMT2C IRS4 MYLK3 SULT2B1 TCN2 MTHFD1L ZKSCAN3 ADAMTS15 GNB4 CUBN

6.94e-067028711C0009402
DiseaseAnemia, Megaloblastic

TCN2 CUBN

8.54e-055872C0002888
DiseaseNephroblastoma

TCN2 PCSK9

3.81e-0410872Orphanet_654
DiseaseBipolar Disorder

CACNA1B CACNA1C SLC25A4 PFKL PPID HSPA4 PALB2

5.30e-04477877C0005586
Diseaserheumatoid arthritis (implicated_via_orthology)

KMT2C ZFP36

5.56e-0412872DOID:7148 (implicated_via_orthology)
Diseasebipolar I disorder

CACNA1C TTBK2 TMEM179 CUBN

8.18e-04141874EFO_0009963
Diseasethyroxine measurement, triiodothyronine measurement

GALNT13 TIAM2

1.14e-0317872EFO_0005130, EFO_0008392
DiseaseColorectal Neoplasms

DPAGT1 SULT2B1 TCN2 ZKSCAN3 GNB4

1.39e-03277875C0009404
Diseasedisease of metabolism (implicated_via_orthology)

ALDH4A1 PFKL

1.74e-0321872DOID:0014667 (implicated_via_orthology)
DiseasePrimary microcephaly

TUBGCP6 TUBGCP3

1.91e-0322872C0431350
DiseaseIntellectual Disability

CACNA1B KMT2C TCN2 ZBTB40 ALDH4A1 ZBTB24

2.10e-03447876C3714756
Diseasebreast cancer, lung cancer

ZKSCAN3 HSPA4

2.47e-0325872MONDO_0007254, MONDO_0008903
DiseasePancytopenia

TCN2 PALB2

2.67e-0326872C0030312
DiseaseIschemic stroke

TTBK1 RXFP2 FBXO11 CRTAC1 GALNT13

2.74e-03324875HP_0002140

Protein segments in the cluster

PeptideGeneStartEntry
DARKCLGRFGLESHA

ABCF1

721

Q8NE71
DNGFFKILRGQDHCG

CTSB

306

P07858
RAKGHRAGEACGKNR

ADGRA2

1186

Q96PE1
CGDGANDCGALKRAH

ATP13A3

881

Q9H7F0
LAGECGGKNFHFVHR

ALDH4A1

311

P30038
KLIRCHQSRGGACGD

BCAS3

246

Q9H6U6
NLGKLVRGDAHECFV

MTHFD1L

186

Q6UB35
ECAGAKGERRARHRG

CACNA1B

946

Q00975
RGFQRRSLKCVGHGG

ADAMTS15

911

Q8TE58
EGSGADCRRHVQKLN

MRNIP

46

Q6NTE8
KGCIHDNRTGNDRVG

CASKIN1

321

Q8WXD9
RAVHGGFEDCRPLNK

KMT2C

4336

Q8NEZ4
GLGVNGKVLECFHRR

MAPKAPK3

51

Q16644
LGGRKFDEVLVNHFC

HSPA4

231

P34932
CAVDNRGGGKHFSGE

MMS22L

31

Q6ZRQ5
QGQGEDKRRVAHLGC

CORO7

61

P57737
AFRGHFIAARLCGQD

DPAGT1

31

Q9H3H5
EAQGGKLVCRAHNAF

PCSK9

501

Q8NBP7
KLVCRAHNAFGGEGV

PCSK9

506

Q8NBP7
LGGGRFGQVHRCTEK

MYLK3

521

Q32MK0
EGKGVFDCRTNVLGH

PFKL

646

P17858
GHACDEDFRGRRQEA

CUEDC1

361

Q9NWM3
ILGGGRFGQVHKCEE

MYLK4

111

Q86YV6
LGHKEARQRCQRAGG

MRC2

1286

Q9UBG0
FEAGRRCHSGEGLFA

DOK3

276

Q7L591
KGDRAGVLAGHDNRV

GNB2

301

P62879
KGDRAGVLAGHDNRV

GNB4

301

Q9HAV0
LAALVDHCQGRKGGE

TUBGCP3

381

Q96CW5
GRDAFDKFCRLHQGE

TUBGCP6

316

Q96RT7
HFGEARLGCAPRFKD

METRNL

276

Q641Q3
DGRLRGHEKFGSCQQ

ITGA6

176

P23229
RGRKFDGHRCAGQQQ

CFP

351

P27918
CGHGRALLFQGVVDD

PADI3

506

Q9ULW8
ACTLHGGKGQEQREF

DDX23

691

Q9BUQ8
GRKENEKVGIFNCHG

GALNT13

446

Q8IUC8
HAGCRFRFGRQDEGS

QRFP

81

P83859
GRFLEGDVKDHCAAA

PALB2

1116

Q86YC2
GFRAQFRQACGGHIL

CUBN

1611

O60494
CDHGKVGFLDRQRTL

EFCAB5

396

A4FU69
DDIFRRAGGLFGNHV

CACNA1C

1741

Q13936
KIHDGRDGGICIFNG

FBXO11

726

Q86XK2
RKGRAGRVASGVCFH

DHX57

961

Q6P158
ARHVRAKRDGCGALE

DIS3L

636

Q8TF46
VIDNRGSCHRGLKFE

DPP8

701

Q6V1X1
FVHGRLKSRNCVVDG

GUCY2F

666

P51841
QGAHGRGHREDFRFC

ADGRG1

21

Q9Y653
NVEKKGHGRINCGRF

AKNAD1

616

Q5T1N1
IQDGGALHIGAEKCR

CEMIP2

181

Q9UHN6
GEGHASCDHRQRGFK

EFNA2

96

O43921
HGRGVALADFNRDGK

CRTAC1

291

Q9NQ79
RKVHNLRILACGGDG

DGKZ

341

Q13574
FAGQRDVFHDLGRGI

KIF28P

81

B7ZC32
CKDIGAIARVHAENG

DPYSL5

181

Q9BPU6
RFEQFCHLRAIGDGE

IRS4

376

O14654
NRVRAVHAGAFGDCG

NYX

216

Q9GZU5
AGKRFCGEHAGAAEE

TRMT13

36

Q9NUP7
DHRRGAFLRKGVCGD

SULT2B1

266

O00204
VLDCFLAKDGAHRGA

TAPBPL

36

Q9BX59
KCNGGRGAIREFAEH

CMAS

406

Q8NFW8
ENFRALCTGEKGIGH

PPID

46

Q08752
RAFHCDGKDDCGNGA

RXFP2

61

Q8WXD0
RDCVKVGGRHGTEVA

RIPOR2

1051

Q9Y4F9
ALRANCEFVRGHKGD

TCN2

111

P20062
CEFVRGHKGDRLVSQ

TCN2

116

P20062
DGIRKHCVEGRLAFA

B4GALNT4

926

Q76KP1
GKGAAQREFHGLGDC

SLC25A4

146

P12235
RGHGRKGEDALCRYF

CNKSR3

451

Q6P9H4
GKDHVCRFIGCGRNE

TTBK1

86

Q5TCY1
NGHDFRGRCLLFTEG

TMEM179

31

Q6ZVK1
LGKLDGCLRVEFHNG

TIAM2

166

Q8IVF5
QDCHFTIRGGRLKED

MIPEP

446

Q99797
LQGKDHVCRFIGCGR

TTBK2

71

Q6IQ55
ENLGRVKRLGCFDHA

UBE2O

331

Q9C0C9
GAKCQFAHGLGELRQ

ZFP36

121

P26651
GANVHARACGRFFQK

TRPV2

186

Q9Y5S1
DEAGAGRALAMGHCR

ZNF276

66

Q8N554
GDKCGLERDETHFQG

ZNF646

736

O15015
RKEDAGRYLCGAHSD

PIGR

316

P01833
ECGKGFNRGAHLIQH

ZNF780A

281

O75290
ECGKGFNRGAHLIQH

ZNF780A

421

O75290
ECGKAFGRSRVLNEH

ZNF141

371

Q15928
GDQEDHGSAKRICGR

ZBTB24

271

O43167
GECGKGFVRRSHLAN

ZNF697

356

Q5TEC3
HLAGRSQCFGRRQGD

ZNF101

416

Q8IZC7
KNATGGRRHICHECG

ZKSCAN3

306

Q9BRR0
EECGKGFGRSLNLRH

ZNF227

691

Q86WZ6
CGKRFAASGDVQRHI

ZBTB49

456

Q6ZSB9
GKCFGGSGDLRRHVR

ZBTB49

541

Q6ZSB9
LSAGGFGEQEGRHCR

LCMT2

371

O60294
NECGKGFGRRSHLAG

ZKSCAN5

636

Q9Y2L8
ACGRGFRRGTDLHKH

ZNF500

441

O60304
KCFEGEGGHSAFQRI

ZBTB40

281

Q9NUA8
ECGEGFVQGAALRRH

ZNF787

321

Q6DD87