Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.98e-1826479GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

3.35e-1552479GO:0005272
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC12A6 SCN11A SLC12A4 ABCA13 SV2A SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SV2C SLC12A7 MFSD1 SLC16A10

4.86e-1311804720GO:0022857
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC12A6 SCN11A SLC12A4 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

1.92e-124654714GO:0046873
GeneOntologyMolecularFunctiontransporter activity

SLC12A6 SCN11A SLC12A4 ABCA13 SV2A SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SV2C SLC12A7 MFSD1 SLC16A10

2.49e-1212894720GO:0005215
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A

6.41e-121714710GO:0015081
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

7.14e-126274715GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

1.61e-116644715GO:0008324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

1.03e-107584715GO:0015318
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A SCN8A SCN9A

1.14e-1014475GO:0031402
GeneOntologyMolecularFunctionchannel activity

SLC12A6 SCN11A SLC12A4 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC12A7

1.54e-105254713GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC12A6 SCN11A SLC12A4 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC12A7

1.57e-105264713GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

1.94e-107934715GO:0015075
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A SCN8A SCN9A

3.68e-0926475GO:0031420
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

5.78e-093434710GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

9.03e-084594710GO:0005216
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A6 SLC12A4 SLC12A7

1.02e-069473GO:0015379
GeneOntologyMolecularFunctionammonium channel activity

SLC12A6 SLC12A4 SLC12A7

2.65e-0612473GO:0008519
GeneOntologyMolecularFunctionprotein kinase binding

CDK9 SLC12A6 KIDINS220 ANGPT1 SLC12A4 MTOR SV2A SCN5A PRKCH SLC12A7 PTK2

4.30e-068734711GO:0019901
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC12A6 SLC12A4 SLC18A3 SLC6A5 SLC12A7 MFSD1 SLC16A10

5.55e-06296477GO:0015291
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A SCN10A

8.12e-0617473GO:0099508
GeneOntologyMolecularFunctionkinase binding

CDK9 SLC12A6 KIDINS220 ANGPT1 SLC12A4 MTOR SV2A SCN5A PRKCH SLC12A7 PTK2

1.16e-059694711GO:0019900
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC12A6 SLC12A4 ABCA13 SLC18A3 SLC6A5 SLC12A7 MFSD1 SLC16A10

1.39e-05477478GO:0022804
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7

2.09e-0523473GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7

3.06e-0526473GO:0015296
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity involved in cardiac muscle cell action potential

SCN5A SCN10A

8.09e-056472GO:0086006
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC6A5 SLC12A7

1.75e-04119474GO:0015294
GeneOntologyMolecularFunctionsymporter activity

SLC12A6 SLC12A4 SLC6A5 SLC12A7

4.24e-04150474GO:0015293
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A6 SLC12A4 SLC18A3 SLC6A5 SLC12A7

6.88e-04301475GO:0022853
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC18A3 SLC6A5 SLC16A10

9.84e-0483473GO:0015101
GeneOntologyMolecularFunctionprotein serine kinase activity

PIK3R4 CDK9 MTOR PRKCH CDC42BPB

1.58e-03363475GO:0106310
GeneOntologyMolecularFunctionprotein kinase activity

PIK3R4 CDK9 MTOR PRKCH CDC42BPB PTK2

2.71e-03600476GO:0004672
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7

3.18e-03125473GO:0015108
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

PIK3R4 CDK9 MTOR PRKCH CDC42BPB

3.85e-03446475GO:0004674
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7

5.39e-03151473GO:0008509
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

PIK3R4 CDK9 MTOR PRKCH CDC42BPB PTK2

6.10e-03709476GO:0016773
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7

7.11e-03167473GO:0015079
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF26 PRAMEF27

7.44e-0355472GO:0042974
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7

7.59e-03171473GO:0015103
GeneOntologyMolecularFunctiongated channel activity

SCN1A TRPC3 SCN2A SCN10A

7.79e-03334474GO:0022836
GeneOntologyMolecularFunctionsnRNA binding

CDK9 RO60

7.97e-0357472GO:0017069
GeneOntologyMolecularFunctionkinase activity

PIK3R4 CDK9 MTOR PRKCH CDC42BPB PTK2

8.68e-03764476GO:0016301
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

SCN1A SCN2A SCN10A

9.00e-03182473GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

SCN1A SCN2A SCN10A

9.27e-03184473GO:0022832
GeneOntologyMolecularFunctionnuclear receptor binding

MED16 PRAMEF26 PRAMEF27

9.69e-03187473GO:0016922
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC6A5 SLC16A10

1.22e-0271472GO:0015179
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

8.11e-1736489GO:0086010
GeneOntologyBiologicalProcessneuronal action potential

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.00e-16634810GO:0019228
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.67e-1462489GO:0086002
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

8.14e-141124810GO:0019226
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

4.05e-1387489GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

7.52e-1393489GO:0086003
GeneOntologyBiologicalProcesscardiac muscle contraction

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

4.63e-121674810GO:0060048
GeneOntologyBiologicalProcessmembrane depolarization

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

8.42e-12121489GO:0051899
GeneOntologyBiologicalProcessactin-mediated cell contraction

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.31e-11127489GO:0070252
GeneOntologyBiologicalProcessaction potential

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.92e-112014810GO:0001508
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A

4.10e-112084810GO:0035725
GeneOntologyBiologicalProcessstriated muscle contraction

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

6.23e-112174810GO:0006941
GeneOntologyBiologicalProcessactin filament-based movement

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

7.03e-11153489GO:0030048
GeneOntologyBiologicalProcessmuscle system process

CDK9 SCN11A MTOR SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A PTK2

2.30e-105474813GO:0003012
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC12A6 SCN11A SLC12A4 MTOR SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

5.52e-1010174816GO:0098660
GeneOntologyBiologicalProcesssodium ion transport

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A

6.31e-102754810GO:0006814
GeneOntologyBiologicalProcessheart contraction

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.37e-092984810GO:0060047
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

1.39e-099224815GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

1.87e-099424815GO:0098655
GeneOntologyBiologicalProcessheart process

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.95e-093094810GO:0003015
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC12A6 SCN11A SLC12A4 MTOR SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

2.09e-0911154816GO:0034220
GeneOntologyBiologicalProcessbehavioral response to pain

SCN11A MTOR SCN3A SCN9A SCN10A

1.06e-0832485GO:0048266
GeneOntologyBiologicalProcessblood circulation

SCN11A ANGPT1 MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A PTK2

2.07e-086484812GO:0008015
GeneOntologyBiologicalProcessmuscle contraction

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.28e-084004810GO:0006936
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC12A6 SCN11A SLC12A4 SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

2.97e-0811574815GO:0006812
GeneOntologyBiologicalProcessmetal ion transport

SLC12A6 SCN11A SLC12A4 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

3.73e-0810004814GO:0030001
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC12A6 SCN11A SLC12A4 MTOR SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SLC6A5 SCN10A SLC12A7

4.05e-0813744816GO:0006811
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A6 SLC12A4 SLC12A7

4.72e-084483GO:0140157
GeneOntologyBiologicalProcesscirculatory system process

SCN11A ANGPT1 MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A PTK2

7.98e-087334812GO:0003013
GeneOntologyBiologicalProcessresponse to pain

SCN11A MTOR SCN3A SCN9A SCN10A

1.19e-0751485GO:0048265
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A6 SLC12A4 SLC12A7 PTK2

3.15e-0725484GO:0055064
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

SLC12A6 SLC12A4 SLC12A7 PTK2

5.07e-0728484GO:0055081
GeneOntologyBiologicalProcessregulation of membrane potential

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

5.11e-075594810GO:0042391
GeneOntologyBiologicalProcessdetection of mechanical stimulus

SCN11A SCN1A SCN9A SCN10A PTK2

8.42e-0775485GO:0050982
GeneOntologyBiologicalProcessdetection of external stimulus

SCN11A SCN1A TRPC3 SCN9A SCN10A PTK2

2.93e-06173486GO:0009581
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception of pain

SCN11A SCN1A SCN9A SCN10A

2.98e-0643484GO:0062149
GeneOntologyBiologicalProcessdetection of abiotic stimulus

SCN11A SCN1A TRPC3 SCN9A SCN10A PTK2

3.13e-06175486GO:0009582
GeneOntologyBiologicalProcessammonium transmembrane transport

SLC12A6 SLC12A4 SLC12A7

3.33e-0613483GO:0072488
GeneOntologyBiologicalProcessactin filament-based process

SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A CDC42BPB

5.98e-069124811GO:0030029
GeneOntologyBiologicalProcesspositive regulation of cardiac muscle hypertrophy

CDK9 MTOR TRPC3 PTK2

7.49e-0654484GO:0010613
GeneOntologyBiologicalProcesspositive regulation of muscle hypertrophy

CDK9 MTOR TRPC3 PTK2

8.07e-0655484GO:0014742
GeneOntologyBiologicalProcessregulation of muscle system process

CDK9 MTOR TRPC3 SCN4A SCN5A SCN10A PTK2

8.13e-06317487GO:0090257
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

SCN11A SCN1A SCN9A SCN10A

9.31e-0657484GO:0050974
GeneOntologyBiologicalProcessmulticellular organismal response to stress

SCN11A MTOR SCN3A SCN9A SCN10A

1.09e-05126485GO:0033555
GeneOntologyBiologicalProcessregulation of muscle adaptation

CDK9 MTOR TRPC3 SCN5A PTK2

1.42e-05133485GO:0043502
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception of pain

SCN11A SCN9A SCN10A

2.96e-0526483GO:0050965
GeneOntologyBiologicalProcessmuscle adaptation

CDK9 MTOR TRPC3 SCN5A PTK2

3.88e-05164485GO:0043500
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

SLC12A6 SLC12A4 FXR2 MTOR SV2A SLC18A3 SLC6A5 SV2C SLC12A7 PTK2

4.58e-059314810GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

SLC12A6 SLC12A4 FXR2 MTOR SV2A SLC18A3 SLC6A5 SV2C SLC12A7 PTK2

4.58e-059314810GO:0007268
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception

SCN11A SCN9A SCN10A

4.59e-0530483GO:0050961
GeneOntologyBiologicalProcesstrans-synaptic signaling

SLC12A6 SLC12A4 FXR2 MTOR SV2A SLC18A3 SLC6A5 SV2C SLC12A7 PTK2

4.92e-059394810GO:0099537
GeneOntologyBiologicalProcessbehavioral response to chemical pain

SCN11A SCN9A

5.28e-055482GO:0061366
GeneOntologyBiologicalProcessbehavioral response to formalin induced pain

SCN11A SCN9A

5.28e-055482GO:0061368
GeneOntologyBiologicalProcessdetection of temperature stimulus

SCN11A SCN9A SCN10A

6.14e-0533483GO:0016048
GeneOntologyBiologicalProcesspositive regulation of glial cell proliferation

MTOR PRKCH PTK2

6.73e-0534483GO:0060252
GeneOntologyBiologicalProcesssynaptic signaling

SLC12A6 SLC12A4 FXR2 MTOR SV2A SLC18A3 SLC6A5 SV2C SLC12A7 PTK2

6.81e-059764810GO:0099536
GeneOntologyBiologicalProcessregulation of cardiac muscle hypertrophy

CDK9 MTOR TRPC3 PTK2

7.63e-0597484GO:0010611
GeneOntologyBiologicalProcessregulation of muscle hypertrophy

CDK9 MTOR TRPC3 PTK2

8.59e-05100484GO:0014743
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A6 SLC12A4 SLC12A7

8.69e-0537483GO:0055075
GeneOntologyBiologicalProcesssensory perception of temperature stimulus

SCN11A SCN9A SCN10A

9.42e-0538483GO:0050951
GeneOntologyBiologicalProcesssensory perception of pain

SCN11A SCN1A SCN9A SCN10A

1.04e-04105484GO:0019233
GeneOntologyBiologicalProcessbundle of His cell action potential

SCN5A SCN10A

1.11e-047482GO:0086043
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte signaling

SCN5A SCN10A

1.11e-047482GO:0086028
GeneOntologyBiologicalProcesscell volume homeostasis

SLC12A6 SLC12A4 SLC12A7

1.27e-0442483GO:0006884
GeneOntologyBiologicalProcessnucleus localization

CDK9 MTOR PTK2

1.46e-0444483GO:0051647
GeneOntologyBiologicalProcessregulation of translation at synapse, modulating synaptic transmission

FXR2 MTOR

1.89e-049482GO:0099547
GeneOntologyBiologicalProcessimport across plasma membrane

SLC12A6 SLC12A4 SCN5A SLC6A5 SLC12A7

1.91e-04230485GO:0098739
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

SCN11A SCN1A SCN8A SCN9A SCN10A

2.24e-04238485GO:0050954
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

SLC12A6 SLC12A4 SLC12A7

2.28e-0451483GO:1990573
GeneOntologyBiologicalProcessregulation of atrial cardiac muscle cell membrane depolarization

SCN5A SCN10A

2.36e-0410482GO:0060371
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC12A6 SLC12A4 MTOR SLC12A7

2.66e-04134484GO:0098661
GeneOntologyBiologicalProcessresponse to mechanical stimulus

SCN11A SCN1A SCN9A SCN10A PTK2

2.66e-04247485GO:0009612
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

SLC12A6 SLC12A4 SCN5A SLC12A7

3.31e-04142484GO:0099587
GeneOntologyBiologicalProcesscardiac muscle hypertrophy

CDK9 MTOR TRPC3 PTK2

3.31e-04142484GO:0003300
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

SLC12A6 SLC12A4 SCN5A SLC12A7

3.31e-04142484GO:0098659
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

SCN5A SCN10A

3.45e-0412482GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

SCN5A SCN10A

3.45e-0412482GO:0086016
GeneOntologyBiologicalProcessorganic cation transport

SLC18A3 SCN4A SLC6A5 SLC16A10

3.59e-04145484GO:0015695
GeneOntologyBiologicalProcessstriated muscle hypertrophy

CDK9 MTOR TRPC3 PTK2

3.68e-04146484GO:0014897
GeneOntologyBiologicalProcessmuscle hypertrophy

CDK9 MTOR TRPC3 PTK2

3.88e-04148484GO:0014896
GeneOntologyBiologicalProcessregulation of glial cell proliferation

MTOR PRKCH PTK2

4.06e-0462483GO:0060251
GeneOntologyBiologicalProcessregulation of translation at synapse

FXR2 MTOR

4.07e-0413482GO:0140243
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC12A6 SLC12A4 MTOR SLC12A7

4.39e-04153484GO:0098656
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte communication

SCN5A SCN10A

5.46e-0415482GO:0086069
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

SCN5A SCN10A

5.46e-0415482GO:0086067
GeneOntologyBiologicalProcesspositive regulation of muscle adaptation

MTOR TRPC3

6.23e-0416482GO:0014744
GeneOntologyBiologicalProcesscellular response to osmotic stress

SLC12A6 MTOR SCN2A

6.30e-0472483GO:0071470
GeneOntologyBiologicalProcessimport into cell

SLC12A6 ANGPT1 SLC12A4 ABCA13 SLC18A3 SCN5A SLC6A5 SLC12A7 PTK2

7.27e-041074489GO:0098657
GeneOntologyBiologicalProcessinorganic anion transport

SLC12A6 SLC12A4 MTOR SLC12A7

8.09e-04180484GO:0015698
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC12A6 SLC12A4 MTOR SLC12A7

8.60e-04183484GO:0006820
GeneOntologyBiologicalProcessbehavior

SCN11A MTOR SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A

9.54e-04891488GO:0007610
GeneOntologyBiologicalProcessresponse to abiotic stimulus

SLC12A6 SCN11A MTOR SCN1A TRPC3 SCN2A SCN9A SCN10A RO60 PTK2

9.85e-0413614810GO:0009628
GeneOntologyBiologicalProcessglial cell proliferation

MTOR PRKCH PTK2

1.09e-0387483GO:0014009
GeneOntologyBiologicalProcessdetection of stimulus

SCN11A OR10A7 SCN1A TRPC3 SCN9A SCN10A PTK2

1.32e-03722487GO:0051606
GeneOntologyBiologicalProcessresponse to temperature stimulus

SCN11A MTOR SCN9A SCN10A

1.38e-03208484GO:0009266
GeneOntologyBiologicalProcessregulation of system process

CDK9 MTOR TRPC3 SCN4A SCN5A SCN10A PTK2

1.45e-03734487GO:0044057
GeneOntologyBiologicalProcesspositive regulation of gliogenesis

MTOR PRKCH PTK2

1.54e-0398483GO:0014015
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of pain

SCN11A SCN1A

1.66e-0326482GO:0050966
GeneOntologyBiologicalProcessregulation of cell size

SLC12A6 SLC12A4 MTOR SLC12A7

1.84e-03225484GO:0008361
GeneOntologyBiologicalProcessnerve development

SCN1A SCN2A SCN8A

2.09e-03109483GO:0021675
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.35e-2017499GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

9.48e-1829499GO:0034706
GeneOntologyCellularComponentcation channel complex

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.49e-102354910GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.46e-083784910GO:0034702
GeneOntologyCellularComponenttransmembrane transporter complex

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

3.02e-075234910GO:1902495
GeneOntologyCellularComponenttransporter complex

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

4.78e-075504910GO:1990351
GeneOntologyCellularComponentaxon

SLC12A6 SCN11A SLC18A3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

5.23e-068914911GO:0030424
GeneOntologyCellularComponentplasma membrane protein complex

SCN11A SLC18A3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.15e-057854910GO:0098797
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

1.34e-0520493GO:0033268
GeneOntologyCellularComponentintercalated disc

SCN1A SCN2A SCN5A PTK2

1.94e-0568494GO:0014704
GeneOntologyCellularComponentC-fiber

SCN11A SCN10A

3.22e-054492GO:0044299
GeneOntologyCellularComponentpresynapse

SCN11A FXR2 SV2A SLC18A3 SCN1A SCN2A SCN8A SLC6A5 SCN10A SV2C

3.25e-058864910GO:0098793
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A SCN8A

4.24e-0529493GO:0043194
GeneOntologyCellularComponentpresynaptic membrane

SCN11A SCN1A SCN2A SCN8A SLC6A5 SCN10A

4.45e-05277496GO:0042734
GeneOntologyCellularComponentcell-cell junction

SV2A SCN1A SCN2A SCN5A PRKCH MFRP CDC42BPB PTK2

6.32e-05591498GO:0005911
GeneOntologyCellularComponentcell-cell contact zone

SCN1A SCN2A SCN5A PTK2

6.96e-0594494GO:0044291
GeneOntologyCellularComponentmembrane protein complex

PIK3R4 SCN11A SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.34e-0414984912GO:0098796
GeneOntologyCellularComponentglutamatergic synapse

SCN11A FXR2 MTOR SV2A SCN2A SCN8A SCN10A PTK2

5.72e-04817498GO:0098978
GeneOntologyCellularComponentT-tubule

SCN1A SCN2A SCN5A

8.44e-0479493GO:0030315
GeneOntologyCellularComponentsarcolemma

SCN1A SCN2A SCN5A PTK2

1.02e-03190494GO:0042383
GeneOntologyCellularComponentmain axon

SCN1A SCN2A SCN8A

1.19e-0389493GO:0044304
GeneOntologyCellularComponentanchoring junction

SV2A SCN1A SCN2A SCN5A PRKCH MFRP CDC42BPB PTK2

1.80e-03976498GO:0070161
GeneOntologyCellularComponentsynaptic membrane

SCN11A SCN1A SCN2A SCN8A SLC6A5 SCN10A

2.32e-03583496GO:0097060
GeneOntologyCellularComponentZ disc

SCN1A SCN5A SCN8A

5.34e-03151493GO:0030018
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF26 PRAMEF27

5.44e-0347492GO:0031462
HumanPhenoComplex febrile seizure

SCN1A SCN2A SCN8A SCN9A

5.55e-0716234HP:0011172
HumanPhenoAllodynia

SCN11A SCN9A SCN10A

8.00e-075233HP:0012533
HumanPhenoEEG with spike-wave complexes

MTOR SLC18A3 SCN1A SCN2A SCN8A SCN9A

1.79e-0688236HP:0010850
HumanPhenoDysesthesia

SCN11A SCN9A SCN10A PEX16

1.80e-0621234HP:0012534
HumanPhenoParesthesia

SCN11A GLA SCN1A SCN4A SCN9A SCN10A PEX16

2.09e-06144237HP:0003401
HumanPhenoFocal hemiclonic seizure

SCN1A SCN2A SCN8A SCN9A

3.75e-0625234HP:0006813
HumanPhenoPes valgus

SCN1A SCN2A SCN4A SCN9A CDC42BPB

3.87e-0656235HP:0008081
HumanPhenoPhotosensitive myoclonic seizure

SCN1A SCN2A SCN9A

4.44e-068233HP:0001327
HumanPhenoCyanotic episode

SCN1A SCN2A SCN9A

4.44e-068233HP:0200048
HumanPhenoInterictal epileptiform activity

SLC12A6 MTOR SV2A SLC18A3 SCN1A SCN2A SCN3A SCN8A SCN9A

4.95e-06319239HP:0011182
HumanPhenoSimple febrile seizure

SCN1A SCN2A SCN3A SCN8A

5.18e-0627234HP:0011171
HumanPhenoInterictal EEG abnormality

SLC12A6 MTOR SV2A SLC18A3 SCN1A SCN2A SCN3A SCN8A SCN9A

5.77e-06325239HP:0025373
HumanPhenoErythromelalgia

SCN11A SCN9A SCN10A

9.45e-0610233HP:0032147
HumanPhenoCyanosis

SLC18A3 SCN1A SCN2A SCN4A SCN8A SCN9A

9.47e-06117236HP:0000961
HumanPhenoLimited neck range of motion

SCN1A SCN2A SCN9A

1.30e-0511233HP:0000466
HumanPhenoGeneralized clonic seizure

SCN1A SCN2A SCN8A SCN9A

1.34e-0534234HP:0011169
HumanPhenoEEG with generalized epileptiform discharges

MTOR SV2A SLC18A3 SCN1A SCN2A SCN3A SCN8A SCN9A

1.37e-05270238HP:0011198
HumanPhenoFocal impaired awareness seizure

MTOR SCN1A SCN2A SCN3A SCN8A SCN9A

1.45e-05126236HP:0002384
HumanPhenoEpilepsia partialis continua

SCN1A SCN2A SCN9A

1.72e-0512233HP:0012847
HumanPhenoFocal automatism seizure

SCN1A SCN2A SCN8A

1.72e-0512233HP:0032898
HumanPhenoAbnormal autonomic nervous system physiology

SCN11A GLA SCN3A SCN5A SCN9A SCN10A

1.74e-05130236HP:0012332
HumanPhenoGeneralized cerebral atrophy/hypoplasia

SCN1A SCN2A SCN9A

2.23e-0513233HP:0007058
HumanPhenoClonic seizure

SCN1A SCN2A SCN3A SCN8A SCN9A

2.41e-0581235HP:0020221
HumanPhenoTonic seizure

MTOR SV2A SCN1A SCN2A SCN8A SCN9A

2.66e-05140236HP:0032792
HumanPhenoRigidity

SCN1A SCN2A SCN3A SCN8A SCN9A SLC6A5 PEX16

2.89e-05214237HP:0002063
HumanPhenoFocal clonic seizure

SCN1A SCN2A SCN8A SCN9A

3.16e-0542234HP:0002266
HumanPhenoFacial tics

SCN1A SCN2A SCN9A

3.53e-0515233HP:0011468
HumanPhenoPhotosensitive tonic-clonic seizure

SCN1A SCN2A SCN9A

3.53e-0515233HP:0007207
HumanPhenoDysgenesis of the hippocampus

SCN1A SCN2A SCN9A

4.33e-0516233HP:0025101
HumanPhenoFocal motor status epilepticus

SCN1A SCN2A SCN9A

5.25e-0517233HP:0032663
HumanPhenoAtypical absence status epilepticus

SCN1A SCN2A SCN9A

5.25e-0517233HP:0011151
HumanPhenoEEG abnormality

SLC12A6 MTOR SV2A SLC18A3 SCN1A SCN2A SCN3A SCN8A SCN9A PEX16

5.96e-055482310HP:0002353
HumanPhenoFunctional motor deficit

SLC12A6 GLA MTOR SLC18A3 SCN1A SCN2A SCN4A SCN5A PEX16

6.25e-05436239HP:0004302
HumanPhenoVisually-induced seizure

SCN1A SCN2A SCN9A

6.28e-0518233HP:0020216
HumanPhenoGeneralized non-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A

6.28e-0518233HP:0032860
HumanPhenoNon-convulsive status epilepticus without coma

SCN1A SCN2A SCN9A

8.72e-0520233HP:0032671
HumanPhenoAbnormal exteroceptive sensation

SCN11A GLA SCN1A SCN4A SCN9A SCN10A PEX16

9.84e-05259237HP:0033747
HumanPhenoCortical dysplasia

MTOR SCN1A SCN2A SCN9A

9.93e-0556234HP:0002539
HumanPhenoTalipes valgus

SCN1A SCN2A SCN9A

1.01e-0421233HP:0004684
HumanPhenoReflex seizure

SCN1A SCN2A SCN9A

1.17e-0422233HP:0020207
HumanPhenoLimb tremor

SLC12A6 PEX16 CDC42BPB

1.17e-0422233HP:0200085
HumanPhenoAbnormality of pain sensation

SCN11A SCN1A SCN9A SCN10A PEX16

1.20e-04113235HP:0010832
HumanPhenoFocal tonic seizure

MTOR SCN2A SCN8A

1.34e-0423233HP:0011167
HumanPhenoTibial torsion

SCN1A SCN2A SCN9A

1.34e-0423233HP:0100694
HumanPhenoEEG with focal epileptiform discharges

MTOR SCN1A SCN2A SCN8A SCN9A

1.48e-04118235HP:0011185
HumanPhenoGeneralized tonic seizure

SCN1A SCN2A SCN8A SCN9A

1.68e-0464234HP:0010818
HumanPhenoMultifocal epileptiform discharges

SCN1A SCN2A SCN8A SCN9A

1.89e-0466234HP:0010841
HumanPhenoNeonatal electro-clinical non-motor seizure

SCN2A SCN8A

1.93e-045232HP:0032812
HumanPhenoNeonatal seizure with electrographic correlate

SCN2A SCN8A

1.93e-045232HP:0032808
HumanPhenoNeonatal electro-clinical seizure

SCN2A SCN8A

1.93e-045232HP:0032809
HumanPhenoNeonatal electro-clinical seizure with behavior arrest

SCN2A SCN8A

1.93e-045232HP:0032823
HumanPhenoFocal head nodding automatism seizure

SCN2A SCN8A

1.93e-045232HP:0032906
HumanPhenoEsophoria

KIDINS220 SCN8A

1.93e-045232HP:0025312
HumanPhenoLimited knee extension

SCN1A SCN2A SCN9A

2.19e-0427233HP:0003066
HumanPhenoStatus epilepticus without prominent motor symptoms

SCN1A SCN2A SCN9A

2.19e-0427233HP:0031475
HumanPhenoStatus epilepticus

MTOR SCN1A SCN2A SCN3A SCN8A SCN9A

2.37e-04207236HP:0002133
HumanPhenoFocal motor seizure

MTOR SCN1A SCN2A SCN8A SCN9A

2.42e-04131235HP:0011153
HumanPhenoFocal aware seizure

SCN1A SCN2A SCN9A

2.45e-0428233HP:0002349
HumanPhenoStatus epilepticus with prominent motor symptoms

SCN1A SCN2A SCN9A

2.72e-0429233HP:0032658
HumanPhenoNormal interictal EEG

SCN2A SCN8A

2.89e-046232HP:0002372
HumanPhenoProgressive gait ataxia

SCN1A SCN2A SCN9A

3.02e-0430233HP:0007240
HumanPhenoProgressive ataxia

SCN1A SCN2A SCN9A

3.02e-0430233HP:0001329
HumanPhenoCogwheel rigidity

SCN1A SCN2A SCN9A

3.66e-0432233HP:0002396
HumanPhenoInfection-related seizure

SCN1A SCN2A SCN3A SCN8A SCN9A

3.88e-04145235HP:0032892
HumanPhenoSeizure precipitated by febrile infection

SCN1A SCN2A SCN3A SCN8A SCN9A

3.88e-04145235HP:0032894
HumanPhenoFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A SCN3A SCN8A SCN9A

3.88e-04145235HP:0002373
HumanPhenoObsessive-compulsive trait

SCN1A SCN2A SCN9A

4.02e-0433233HP:0008770
HumanPhenoEyelid myoclonia seizure

SCN2A SCN8A

4.04e-047232HP:0032678
HumanPhenoSomatic sensory dysfunction

SLC12A6 SCN11A GLA SCN1A SCN4A SCN9A SCN10A PEX16

4.38e-04439238HP:0003474
HumanPhenoCalcaneovalgus deformity

SCN1A SCN2A SCN9A

4.39e-0434233HP:0001848
HumanPhenoImpulsivity

SCN1A SCN2A SCN3A SCN8A SCN9A

4.40e-04149235HP:0100710
HumanPhenoDevelopmental regression

GLA SV2A SCN1A SCN2A SCN3A SCN8A SCN9A PEX16

4.45e-04440238HP:0002376
HumanPhenoDeformed tarsal bones

SCN1A SCN2A SCN9A

4.79e-0435233HP:0008119
HumanPhenoLimitation of knee mobility

SCN1A SCN2A SCN9A

4.79e-0435233HP:0010501
HumanPhenoEsodeviation

SLC12A6 KIDINS220 SLC18A3 SCN4A SCN8A CDC42BPB

4.81e-04236236HP:0020045
HumanPhenoLimitation of neck motion

SCN1A SCN2A SCN9A

5.21e-0436233HP:0005986
HumanPhenoAbnormal neck physiology

SCN1A SCN2A SCN9A

5.21e-0436233HP:0025669
HumanPhenoDisturbance of facial expression

SCN1A SCN2A SCN9A

5.21e-0436233HP:0005324
HumanPhenoGait disturbance

SLC12A6 KIDINS220 MTOR AOPEP SLC18A3 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN8A SCN9A SLC6A5 PEX16

5.55e-0413562314HP:0001288
HumanPhenoDialeptic seizure

MTOR SCN1A SCN2A SCN3A SCN8A SCN9A

6.69e-04251236HP:0011146
HumanPhenoFocal non-motor seizure

SCN1A SCN2A SCN8A

7.13e-0440233HP:0032679
HumanPhenoAbnormality of central nervous system electrophysiology

SLC12A6 MTOR SV2A SLC18A3 SCN1A SCN2A SCN3A SCN8A SCN9A PEX16

7.32e-047382310HP:0030178
HumanPhenoAtonic seizure

MTOR SCN1A SCN2A SCN9A

7.36e-0494234HP:0010819
HumanPhenoGait ataxia

SCN1A TRPC3 SCN2A SCN8A SCN9A PEX16

8.57e-04263236HP:0002066
HumanPhenoApneic episodes in infancy

SCN4A SCN5A

8.59e-0410232HP:0005949
HumanPhenoSudden unexpected death in epilepsy

SCN1A SCN8A

8.59e-0410232HP:0033258
HumanPhenoBradycardia

SCN4A SCN5A SCN9A SCN10A

8.61e-0498234HP:0001662
HumanPhenoReduced tendon reflexes

SLC12A6 SCN11A SLC18A3 SCN3A SCN4A SCN8A SCN9A SCN10A PEX16

8.96e-04617239HP:0001315
HumanPhenoMyoclonus

MTOR SCN1A SCN2A SCN3A SCN8A SCN9A SLC6A5

9.05e-04371237HP:0001336
HumanPhenoApnea

SLC18A3 SCN2A SCN4A SCN5A SCN8A SLC6A5 CDC42BPB

9.20e-04372237HP:0002104
HumanPhenoInvoluntary movements

SLC12A6 GLA MTOR SV2A SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A SLC6A5 PEX16 CDC42BPB

9.87e-0412482313HP:0004305
HumanPhenoNeonatal seizure

SCN2A SCN8A

1.05e-0311232HP:0032807
HumanPhenoHeterophoria

KIDINS220 SCN8A

1.05e-0311232HP:0032011
HumanPhenoAbnormal nervous system electrophysiology

SLC12A6 MTOR SV2A SLC18A3 SCN1A SCN2A SCN3A SCN4A SCN8A SCN9A PEX16

1.06e-039242311HP:0001311
HumanPhenoAtypical absence seizure

SCN1A SCN2A SCN9A

1.08e-0346233HP:0007270
HumanPhenoSensory neuropathy

SLC12A6 SCN11A GLA SCN1A SCN4A SCN9A SCN10A PEX16

1.10e-03503238HP:0000763
HumanPhenoAbnormal hippocampus morphology

SCN1A SCN2A SCN9A

1.22e-0348233HP:0025100
HumanPhenoAbnormal morphology of the limbic system

SCN1A SCN2A SCN9A

1.29e-0349233HP:0007343
HumanPhenoEEG with polyspike wave complexes

MTOR SLC18A3 SCN1A

1.29e-0349233HP:0002392
HumanPhenoBilateral tonic-clonic seizure

SV2A SCN1A SCN2A SCN3A SCN8A SCN9A SLC6A5

1.29e-03394237HP:0002069
MousePhenoabnormal action potential

SCN11A SCN1A SCN2A SCN5A SCN8A SCN9A SCN10A

1.46e-07133437MP:0005402
MousePhenoabnormal nervous system electrophysiology

SLC12A6 SCN11A SCN1A TRPC3 SCN2A SCN5A SCN8A SCN9A SCN10A

5.53e-07329439MP:0002272
MousePhenoseizures

SLC12A6 SV2A SLC18A3 SCN1A SCN5A SCN8A SCN9A SLC6A5

1.18e-05360438MP:0002064
MousePhenoabnormal synaptic transmission

SLC12A6 SCN11A KIDINS220 FXR2 ABCA13 SV2A SLC18A3 SCN1A TRPC3 SCN2A SCN8A SCN9A SLC6A5

1.20e-0510704313MP:0003635
MousePhenoabnormal synaptic physiology

SLC12A6 SCN11A KIDINS220 FXR2 ABCA13 SV2A SLC18A3 SCN1A TRPC3 SCN2A SCN8A SCN9A SLC6A5

1.28e-0510764313MP:0021009
MousePhenoakinesia

SLC12A6 SCN1A SCN4A

3.47e-0521433MP:0002690
MousePhenoabnormal muscle tone

SLC12A6 SLC18A3 SCN8A SLC6A5

5.48e-0568434MP:0004142
MousePhenoabnormal endocardium morphology

ANGPT1 SCN8A PTK2

7.53e-0527433MP:0003974
MousePhenoabnormal CNS synaptic transmission

SLC12A6 SCN11A KIDINS220 FXR2 ABCA13 SV2A SCN1A TRPC3 SCN2A SCN9A SLC6A5

1.42e-049854311MP:0002206
MousePhenoabnormal single cell response

SCN11A SCN9A SCN10A

1.66e-0435433MP:0003463
MousePhenoabnormal mechanical nociception

SCN11A SCN9A SCN10A

1.80e-0436433MP:0002734
MousePhenoventricular fibrillation

SCN1A SCN5A

1.92e-047432MP:0006110
MousePhenomuscle hypertonia

SLC12A6 SLC6A5

3.28e-049432MP:0004143
MousePhenoabnormal seizure response to inducing agent

SLC12A6 SLC18A3 SCN1A SCN8A SCN9A

3.61e-04201435MP:0009357
MousePhenoperipheral nervous system degeneration

SLC12A6 SCN8A

4.09e-0410432MP:0000958
DomainNa_channel_asu

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.79e-2310479IPR001696
DomainNa_trans_assoc

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.79e-2310479IPR010526
DomainNa_trans_assoc

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.79e-2310479PF06512
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A

1.82e-166476PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A

1.82e-166476IPR024583
DomainChannel_four-helix_dom

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.48e-1457479IPR027359
Domain-

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.48e-14574791.20.120.350
DomainIon_trans_dom

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.06e-131144710IPR005821
DomainIon_trans

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.06e-131144710PF00520
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

5.71e-1190478IPR000048
DomainIQ

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

7.46e-1193478PS50096
DomainIQ

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A

1.21e-0981477SM00015
DomainIQ

SCN1A SCN3A SCN4A SCN8A SCN9A SCN10A

2.31e-0871476PF00612
DomainKCL_cotranspt

SLC12A6 SLC12A4 SLC12A7

5.96e-084473IPR000076
DomainSLC12A_fam

SLC12A6 SLC12A4 SLC12A7

5.19e-077473IPR004842
DomainSLC12

SLC12A6 SLC12A4 SLC12A7

8.29e-078473PF03522
DomainSLC12_C

SLC12A6 SLC12A4 SLC12A7

8.29e-078473IPR018491
DomainMFS

SV2A SLC18A3 SV2C MFSD1 SLC16A10

1.40e-0677475IPR011701
DomainMFS_1

SV2A SLC18A3 SV2C MFSD1 SLC16A10

1.40e-0677475PF07690
DomainKCC1

SLC12A6 SLC12A4

6.20e-062472IPR000622
DomainMFS

SV2A SLC18A3 SV2C MFSD1 SLC16A10

7.45e-06108475PS50850
DomainPentapeptide_4

SV2A SV2C

1.86e-053472PF13599
DomainSV2

SV2A SV2C

1.86e-053472IPR022308
DomainMFS_dom

SV2A SLC18A3 SV2C MFSD1 SLC16A10

2.12e-05134475IPR020846
DomainAA-permease/SLC12A_dom

SLC12A6 SLC12A4 SLC12A7

2.22e-0522473IPR004841
DomainAA_permease

SLC12A6 SLC12A4 SLC12A7

2.22e-0522473PF00324
Domain5peptide_repeat

SV2A SV2C

3.71e-054472IPR001646
DomainPRAME_family

PRAMEF25 PRAMEF27

1.03e-0319472IPR026271
DomainDAG/PE-bd

PRKCH CDC42BPB

1.26e-0321472IPR020454
DomainKinase-like_dom

PIK3R4 CDK9 MTOR PRKCH CDC42BPB PTK2

2.27e-03542476IPR011009
DomainSugar_transporter_CS

SV2A SV2C

2.93e-0332472IPR005829
DomainSugar_tr

SV2A SV2C

3.70e-0336472PF00083
DomainMFS_sugar_transport-like

SV2A SV2C

3.70e-0336472IPR005828
DomainPkinase_C

PRKCH CDC42BPB

3.90e-0337472IPR017892
DomainLDLR_class-A_CS

TMPRSS2 MFRP

4.55e-0340472IPR023415
DomainPkinase_C

PRKCH CDC42BPB

5.01e-0342472PF00433
DomainPROTEIN_KINASE_ATP

PIK3R4 CDK9 PRKCH CDC42BPB PTK2

5.76e-03459475PS00107
DomainEF-hand-dom_pair

SCN1A SCN3A SCN8A SCN9A

5.80e-03287474IPR011992
Domain-

TMPRSS2 MFRP

5.98e-03464724.10.400.10
DomainLDLRA_1

TMPRSS2 MFRP

6.49e-0348472PS01209
DomainLDrepeatLR_classA_rpt

TMPRSS2 MFRP

6.76e-0349472IPR002172
DomainLDLa

TMPRSS2 MFRP

6.76e-0349472SM00192
DomainLDLRA_2

TMPRSS2 MFRP

6.76e-0349472PS50068
DomainProt_kinase_dom

PIK3R4 CDK9 PRKCH CDC42BPB PTK2

7.48e-03489475IPR000719
DomainPROTEIN_KINASE_DOM

PIK3R4 CDK9 PRKCH CDC42BPB PTK2

7.74e-03493475PS50011
DomainAGC-kinase_C

PRKCH CDC42BPB

8.75e-0356472IPR000961
DomainAGC_KINASE_CTER

PRKCH CDC42BPB

8.75e-0356472PS51285
DomainS_TK_X

PRKCH CDC42BPB

8.75e-0356472SM00133
DomainC1_1

PRKCH CDC42BPB

9.06e-0357472PF00130
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

6.78e-1731399M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

9.41e-1732399M27455
PathwayREACTOME_L1CAM_INTERACTIONS

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

3.19e-11121399M872
PathwayREACTOME_CARDIAC_CONDUCTION

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

6.12e-11130399M27454
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

PIK3R4 SCN11A MTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.80e-093673911M48346
PathwayREACTOME_MUSCLE_CONTRACTION

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

3.25e-09203399M5485
PathwayWP_DRAVET_SYNDROME

MTOR SCN1A SCN2A SCN3A SCN8A

1.17e-0828395M45519
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

SCN11A SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A PTK2

2.80e-075753911M29853
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7

6.80e-077393M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7

6.80e-077393MM15081
PathwayWP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION

SCN8A SCN9A SCN10A PRKCH

7.51e-0646394M46450
PathwayREACTOME_TOXICITY_OF_BOTULINUM_TOXIN_TYPE_D_BOTD

SV2A SV2C

7.42e-055392M27427
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC12A6 SLC12A4 SLC12A7 SLC16A10

2.18e-04108394M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC12A6 SLC12A4 SLC12A7 SLC16A10

2.26e-04109394MM15074
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

SCN2A SCN3A SCN9A

2.92e-0447393M42524
PathwayWP_RETT_SYNDROME

SCN1A SCN2A SCN8A

3.11e-0448393M39759
PathwayREACTOME_NEUROTOXICITY_OF_CLOSTRIDIUM_TOXINS

SV2A SV2C

3.31e-0410392M27018
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

SCN11A MED16 SCN1A TRPC3 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A PTK2

3.31e-0414323912M509
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC12A6 SLC12A4 SLC6A5 SLC12A7 SLC16A10

4.74e-04238395MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC12A6 SLC12A4 SLC6A5 SLC12A7 SLC16A10

5.82e-04249395M5988
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1

PIK3R4 MTOR

8.73e-0416392M47457
PathwayWP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL

MTOR SCN1A SCN3A

1.07e-0373393MM16641
PathwayWP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_AUTOPHAGY

PIK3R4 MTOR

1.24e-0319392M39903
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.22e-26950916382098
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A

6.47e-18650623652591
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

1.40e-171350715123669
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A

5.42e-16950615746173
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN11A SCN3A SCN5A SCN8A SCN9A

5.00e-15550522875929
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN4A SCN5A SCN8A

5.00e-15550517724025
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A SCN8A

3.78e-12450417537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A SCN8A

3.78e-12450435031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A SCN8A

3.78e-12450429578003
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN5A SCN8A

3.93e-121250530175250
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A SCN9A

1.89e-1155048812438
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

SCN11A SCN1A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.47e-1113950816985003
Pubmed

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.

SCN11A SCN8A SCN9A SCN10A

5.66e-11650416029194
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

SCN11A SCN3A SCN8A SCN10A

5.66e-11650423711479
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN11A SCN3A SCN9A SCN10A

1.32e-10750424440715
Pubmed

Significant determinants of mouse pain behaviour.

SCN11A SCN3A SCN9A SCN10A

2.63e-10850425101983
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

2.80e-09350319284629
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

2.80e-09350312610651
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A SCN9A

2.80e-09350333895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

2.80e-09350323859570
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A SCN10A

2.80e-09350319699781
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

2.80e-09350318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

2.80e-09350317544618
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

2.80e-09350332845893
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN5A SCN9A

2.80e-09350320038812
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

2.80e-09350328518218
Pubmed

Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.

SCN11A SCN9A SCN10A

2.80e-09350338999942
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

2.80e-09350317928448
Pubmed

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.

SCN11A SCN9A SCN10A

2.80e-09350330554136
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

2.80e-09350314973256
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A6 SLC12A4 SLC12A7

2.80e-09350311551954
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A6 SLC12A4 SLC12A7

2.80e-09350315262997
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A6 SLC12A4 SLC12A7

2.80e-09350321733850
Pubmed

Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.

SCN11A SCN8A SCN9A

2.80e-09350315302875
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

1.12e-08450321156207
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A SCN10A

1.12e-08450322260870
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A6 SLC12A4 SLC12A7

1.12e-08450312637262
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

1.12e-08450335801810
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

1.12e-0845038974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

2.79e-0855031679748
Pubmed

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.

SCN11A SCN9A SCN10A

2.79e-08550337117223
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

2.79e-08550324337656
Pubmed

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

SCN11A SCN2A SCN8A

5.57e-08650317513486
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

9.75e-08750325818041
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN5A SCN8A

9.75e-08750315272007
Pubmed

A role for Piezo2 in EPAC1-dependent mechanical allodynia.

SCN11A SCN9A SCN10A

9.75e-08750323575686
Pubmed

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

SLC12A6 SLC12A4 SLC12A7

1.56e-07850311395011
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

SLC12A6 SLC12A4 SLC12A7

1.56e-07850324393035
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A6 SLC12A4 SLC12A7

1.56e-07850321613606
Pubmed

Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.

SCN1A SCN4A SCN5A

1.56e-0785039412493
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A6 SLC12A4 SLC12A7

1.56e-07850312386165
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN3A SCN9A SCN10A

2.33e-0795038854872
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN5A SCN8A

2.33e-07950317884088
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A6 SLC12A4 SLC12A7

2.33e-07950319323993
Pubmed

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

SLC12A6 SLC12A4 MTOR

6.09e-071250327782176
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

6.09e-07125038169823
Pubmed

Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase.

SV2A SLC18A3 SV2C

1.01e-061450312441053
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

1.26e-06155039726281
Pubmed

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

SCN5A SCN10A

2.03e-06250224642470
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

2.03e-06250229649454
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

2.03e-06250220346423
Pubmed

Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.

SCN11A SCN10A

2.03e-06250229970412
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

2.03e-06250237901435
Pubmed

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

SLC12A6 SLC12A4

2.03e-06250234031912
Pubmed

State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.

SCN4A SCN9A

2.03e-06250218079277
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

2.03e-06250226410685
Pubmed

Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina.

SCN11A SCN10A

2.03e-06250218399542
Pubmed

Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.

SCN11A SCN10A

2.03e-06250224144460
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

2.03e-06250210827969
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

2.03e-06250219694741
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

2.03e-06250235348308
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

2.03e-06250211245985
Pubmed

Kinetic Analysis of Membrane Potential Dye Response to NaV1.7 Channel Activation Identifies Antagonists with Pharmacological Selectivity against NaV1.5.

SCN5A SCN9A

2.03e-06250226861708
Pubmed

Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.

SCN5A SCN10A

2.03e-06250215047701
Pubmed

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

SCN9A SCN10A

2.03e-06250216111501
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

2.03e-06250215760941
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

2.03e-0625021317301
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

2.03e-06250223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

2.03e-06250227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

2.03e-06250233096315
Pubmed

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

SLC12A6 SLC12A7

2.03e-06250231393094
Pubmed

Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis.

MTOR PTK2

2.03e-06250226295809
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

2.03e-06250224990319
Pubmed

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

SCN4A SCN5A

2.03e-06250230944319
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

2.03e-06250225172946
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

2.03e-06250231439038
Pubmed

Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.

SCN5A SCN10A

2.03e-06250231292628
Pubmed

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia.

MTOR PTK2

2.03e-06250226892465
Pubmed

Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.

SCN11A SCN10A

2.03e-06250228450535
Pubmed

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.

SCN1A SCN5A

2.03e-06250216054936
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

2.03e-06250217805013
Pubmed

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

SLC12A6 SLC12A4

2.03e-06250217510708
Pubmed

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.

SCN1A SCN5A

2.03e-06250233712547
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

2.03e-06250226311622
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

2.03e-06250233411788
Pubmed

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.

SCN11A SCN10A

2.03e-06250219931571
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

2.03e-06250231943325
Pubmed

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.

SCN4A SCN5A

2.03e-06250211834499
Pubmed

Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.

SCN11A SCN10A

2.03e-06250234930944
Pubmed

Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice.

SCN11A SCN10A

2.03e-06250216857712
InteractionSCN11A interactions

SCN11A SCN1A SCN5A SCN8A SCN9A SCN10A

4.97e-1315466int:SCN11A
InteractionSCN5A interactions

SCN11A SCN1A SCN5A SCN8A SCN9A SCN10A

1.01e-0947466int:SCN5A
InteractionCACNA1D interactions

SCN11A SCN1A SCN5A SCN9A SCN10A

2.04e-0924465int:CACNA1D
InteractionSCN1A interactions

SCN11A SCN1A SCN5A SCN9A SCN10A

5.64e-0929465int:SCN1A
InteractionSCN10A interactions

SCN11A SCN1A SCN5A SCN10A

7.75e-0911464int:SCN10A
InteractionNALCN interactions

SCN11A SCN1A SCN5A SCN9A

2.34e-0814464int:NALCN
InteractionSCN8A interactions

SCN11A SCN4A SCN5A SCN8A

1.12e-0720464int:SCN8A
InteractionSCN9A interactions

SCN11A SCN1A SCN5A SCN9A

1.38e-0721464int:SCN9A
InteractionSCN4B interactions

SCN1A SCN2A SCN8A

6.18e-078463int:SCN4B
InteractionCACNA1B interactions

SCN11A SCN1A SCN5A SCN9A

1.48e-0637464int:CACNA1B
InteractionNEDD4L interactions

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

7.50e-06320467int:NEDD4L
InteractionCACNA1A interactions

SCN11A SCN1A SCN5A SCN9A SCN10A

8.76e-06123465int:CACNA1A
InteractionCACNA1C interactions

SCN11A SCN1A SCN5A SCN9A

1.13e-0561464int:CACNA1C
InteractionTMC4 interactions

SLC12A6 SLC12A4 SLC12A7

4.33e-0530463int:TMC4
InteractionTTYH1 interactions

SLC12A6 KIDINS220 SLC12A4 SNX25 PEX16 SLC12A7

5.88e-05300466int:TTYH1
InteractionLGALS9C interactions

SLC12A6 SLC12A4 SLC12A7

6.92e-0535463int:LGALS9C
InteractionMS4A15 interactions

SLC12A6 SLC12A4 SLC12A7

9.60e-0539463int:MS4A15
InteractionNRN1 interactions

SLC12A6 SLC12A4 SLC12A7

1.04e-0440463int:NRN1
InteractionMARCHF4 interactions

SLC12A6 GLA SLC12A4 SLC12A7

1.23e-04112464int:MARCHF4
InteractionOR10S1 interactions

SLC12A6 SLC12A4

1.41e-048462int:OR10S1
InteractionLGALS9B interactions

SLC12A6 SLC12A4 SLC12A7

1.48e-0445463int:LGALS9B
InteractionRHOH interactions

SLC12A6 KIDINS220 SLC12A4 MTOR SLC12A7 CDC42BPB PCDH7

1.49e-04512467int:RHOH
InteractionZDHHC12 interactions

SLC12A6 SLC12A4 SNX25 SLC12A7

1.77e-04123464int:ZDHHC12
InteractionOR10H1 interactions

SLC12A6 SLC12A4 SLC12A7

1.91e-0449463int:OR10H1
InteractionDNAJC5 interactions

KIDINS220 SV2A SLC18A3 SCN2A CDC42BPB PCDH7

2.08e-04378466int:DNAJC5
InteractionNEDD4 interactions

SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

2.16e-04544467int:NEDD4
InteractionRHOV interactions

KIDINS220 MTOR SLC12A7 CDC42BPB PTK2

2.24e-04243465int:RHOV
InteractionDPM2 interactions

SLC12A6 SLC12A4 SLC12A7

2.54e-0454463int:DPM2
InteractionSLC17A2 interactions

SLC12A6 SLC12A4 SLC12A7

2.83e-0456463int:SLC17A2
InteractionRAB35 interactions

SLC12A6 KIDINS220 SLC12A4 SLC6A5 SLC12A7 CDC42BPB PCDH7

2.96e-04573467int:RAB35
InteractionGJA1 interactions

PIK3R4 KIDINS220 SLC12A4 SCN4A SLC12A7 CDC42BPB PCDH7

3.29e-04583467int:GJA1
InteractionRND3 interactions

KIDINS220 ANGPT1 SLC12A7 CDC42BPB PCDH7

3.83e-04273465int:RND3
InteractionRHOQ interactions

KIDINS220 SLC12A4 MTOR SLC12A7 CDC42BPB PCDH7

4.79e-04442466int:RHOQ
InteractionOR10H2 interactions

SLC12A6 SLC12A4 SLC12A7

5.94e-0472463int:OR10H2
InteractionLAMP1 interactions

KIDINS220 GLA MTOR TMPRSS2 SLC12A7 PCDH7 SLC16A10

5.96e-04644467int:LAMP1
InteractionC3orf52 interactions

SLC12A6 KIDINS220 SLC12A4 TMPRSS2 SLC12A7

6.34e-04305465int:C3orf52
CytobandEnsembl 112 genes in cytogenetic band chr2q24

SCN1A SCN2A SCN3A SCN9A

1.17e-05127504chr2q24
Cytoband2q24

SCN3A SCN9A

6.35e-05115022q24
Cytoband2q24.3

SCN1A SCN2A

1.38e-04165022q24.3
Cytoband3p22.2

SCN11A SCN10A

3.16e-04245023p22.2
CytobandEnsembl 112 genes in cytogenetic band chr3p22

SCN11A SCN5A SCN10A

1.08e-03184503chr3p22
Cytoband1p36.21

PRAMEF25 PRAMEF26

2.18e-03635021p36.21
GeneFamilySodium voltage-gated channel alpha subunits

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

2.87e-2593891203
GeneFamilyPRAME family

PRAMEF25 PRAMEF26 PRAMEF27

1.68e-0524383686
GeneFamilySolute carriers

SLC12A6 SLC12A4 SLC18A3 SLC6A5 SLC12A7 SLC16A10

1.60e-04395386752
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

MSANTD1 KIDINS220 SV2A SCN2A SCN3A PCDH7

8.84e-081975064961f66606f08e399508fd6cabca588e7ab406a8
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SV2A SCN2A SCN3A SCN9A SV2C

2.20e-06188505b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell11.5-Airway-Epithelial-Epithelial|Airway / Age, Tissue, Lineage and Cell class

SLC18A3 SCN2A SCN3A SCN5A SV2C

2.44e-06192505a77d3692ff02ef7e066a9bd9e22725055a25c4d4
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A SCN2A SCN3A SCN9A PCDH7

2.97e-062005054fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A SCN2A SCN3A SCN9A PCDH7

2.97e-06200505f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A SCN2A SCN3A SCN9A PCDH7

2.97e-06200505cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A SCN2A SCN3A SCN9A PCDH7

2.97e-06200505310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A SCN2A SCN3A SCN9A PCDH7

2.97e-06200505c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SCN1A SCN2A SCN3A SCN9A PCDH7

2.97e-06200505961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 SCN1A SCN9A SCN10A

2.12e-0514550496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A BPIFB4 TNMD

2.18e-05146504e887e9de895fd453faa703997ef372cc6410fc49
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A SCN1A SCN3A SCN5A

3.20e-05161504133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A SCN1A SCN3A SCN5A

3.20e-05161504cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A SCN1A SCN3A SCN5A

3.20e-051615049466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A SCN1A SCN3A SCN5A

3.28e-0516250496c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A TRPC3 SCN3A SCN5A

3.52e-05165504347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A TRPC3 SCN3A SCN5A

3.52e-051655041890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A TRPC3 SCN3A SCN5A

3.52e-05165504507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A TRPC3 SCN3A SCN5A

3.52e-0516550439a25be081a5d59c7cf107a997d352793d5025fb
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-9|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC12A4 SCN3A CDC42BPB PTK2

4.63e-05177504ae55773c531099a9e94f44f01ba48b5e71dddc53
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A PCDH7 SLC16A10

4.63e-05177504f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SCN11A SLC18A3 TNMD

4.66e-05625033eec7f31de7cc24762c5b180475650676437dc76
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(Neuron.Gad1Gad2.Sst-Nr2f2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

B3GNT4 SCN11A CD101

4.66e-0562503461d280a1b955033186cfc326f9ace85b4a53c54
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Nefm_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SCN11A SLC18A3 TNMD

4.66e-0562503f5f5441f5be00ab80a7827c4af1afbe45c552c2e
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(Neuron.Gad1Gad2.Sst-Nr2f2)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

B3GNT4 SCN11A CD101

4.66e-05625039db88da996b9977f5a89afe505cd55e7b5324bc9
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nefm-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Nefm_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SCN11A SLC18A3 TNMD

4.66e-05625036e81a37b9defa96528654bee1b23152108d9c0b7
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANGPT1 TRPC3 SCN5A PTK2

4.84e-05179504bfc226bcf0b93525992344f968268a261d86fcbf
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC18A3 SCN2A SCN8A SV2C

4.84e-05179504228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANGPT1 TRPC3 SCN5A PTK2

4.84e-0517950436ad18f52e175ab636ceaa3be81212fa362c96c1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A PCDH7 PTK2 SLC16A10

5.05e-05181504b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

B3GNT4 SCN2A SCN3A SV2C

5.38e-05184504571136c832cb8c08457744152231537aa8e8abd7
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN11A SLC18A3 SCN5A SV2C

5.38e-05184504abb61e744a9031e0c91eb560a8f486a0ca5a01cc
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 SCN2A SCN3A PCDH7

5.61e-05186504d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 SCN2A SCN3A PCDH7

5.61e-0518650408632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SCN2A SCN3A SCN8A SV2C

5.61e-05186504b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A PCDH7 SLC16A10

5.73e-051875042d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A TRPC3 SCN2A SCN8A

5.73e-051875047b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A TRPC3 SCN8A SLC6A5

5.85e-051885041efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 SCN2A SCN3A PCDH7

5.85e-051885044154f4787483c7e076e87a187733a9f666742c3d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A PCDH7 SLC16A10

5.97e-051895043a295c215b5c18e7c673f92b7af5be523421682c
ToppCellwk_15-18-Epithelial-PNS-PCP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

B3GNT4 SLC18A3 SCN2A SV2C

5.97e-0518950422c927d2691b867fbdee1fbee042a6d3f7eadd7d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 SCN2A SCN3A PCDH7

5.97e-0518950490aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SCN2A SCN3A SCN9A

6.10e-051905046e92c78799f34b31d098854503c796edb0dc7f80
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

SV2A SCN2A SCN3A SCN9A

6.22e-0519150476311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC18A3 SCN2A SCN5A SCN9A

6.61e-0519450415224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC18A3 SCN2A SCN5A SV2C

7.01e-051975045593721407f61fc5bc3f2f8bf8fa2604c4e29565
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC18A3 SCN2A SCN5A SV2C

7.01e-05197504a1ae1aa797762a3768e14434c7e5cd19c595ecb3
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC18A3 SCN3A SCN9A SV2C

7.01e-05197504f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

7.15e-05198504c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SCN2A SCN3A SCN8A SLC6A5

7.15e-051985048f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SCN2A SCN3A SCN8A SLC6A5

7.15e-05198504e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

7.15e-051985046d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN8A PCDH7

7.15e-051985048ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A SCN2A SCN3A SCN8A

7.15e-051985044ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCN1A SCN2A SCN9A PCDH7

7.29e-0519950419a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GLA SCN4A MFSD1 SLC16A10

7.29e-05199504667b8b47a5b388506e3177b46747267fad8024f6
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

KIDINS220 SCN2A SCN3A SCN9A

7.44e-05200504db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

KIDINS220 SCN2A SCN3A SCN9A

7.44e-0520050430a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SV2A SCN2A SCN3A

7.44e-0520050468c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Interneuron|2m / Sample Type, Dataset, Time_group, and Cell type.

KIDINS220 SV2A SCN2A SV2C

7.44e-0520050408bee924a2654e05df3b39e8a51f93c8b3472175
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Lhx8-Inhibitory_Neuron.Gad1Gad2-Chat_(Nucleus_basalis_(NB))-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SLC18A3 SCN9A SV2C

2.77e-0411350334ae3dec5ec7585d155ea61de6adc42aa4f45226
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Lhx8-Inhibitory_Neuron.Gad1Gad2-Chat_(Nucleus_basalis_(NB))|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SLC18A3 SCN9A SV2C

2.77e-0411350379ba2eb8f85e5da4c19c838df881c18ffdc450fb
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Lhx8|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SLC18A3 SCN9A SV2C

2.77e-0411350391d55fe6fb1c1472867d74461f5b9e4f17db01cd
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Col8a1_Rxfp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN11A SLC12A7 TNMD

4.28e-0413150381efe8b0ca4377e557a42ddb12aecaf3f46b15bf
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_P2ry12|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN11A SCN10A TNMD

4.28e-0413150380630812f8894b9358d36dc2dd03fea7ee870502
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_VISp_Crh|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCN10A SV2C TNMD

4.77e-0413650344f03e4f55fb2c5f8b9397142c89f7194b009cc6
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC18A3 SCN9A

4.88e-04137503d346086f42d8f04d3fa67fe696834284acdc7080
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SLC18A3 SCN5A SCN9A

5.09e-04139503408bc31aa5e1c2b379f79198fe8b5411f8d7bd08
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANGPT1 SCN2A PCDH7

5.52e-04143503990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 SCN9A TNMD

5.64e-041445031d05aa08603cba28c0c6511767e434c1f592a3aa
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC18A3 SCN5A

5.64e-041445030322fef818a963be00535d5f141f028d43de5c6a
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MSANTD1 SLC18A3 SCN5A

5.64e-0414450304f9054895be2275eecda687a6eeb02fa5ec69b9
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPC3 SCN9A TNMD

5.64e-04144503d3f6f5da56794367ee3776bfd3a9dcf893efe0f0
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC18A3 SCN5A

5.75e-04145503590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A SLC16A10

5.98e-041475032885978bcfc5623967c0c1204dadf5c78c74a082
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC18A3 SCN5A

6.10e-041485039205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC18A3 SCN5A

6.22e-0414950398ae408d2d0347865875ff8bbd89d359decea526
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SV2A TRPC3 SCN3A

6.60e-041525030cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SV2A TRPC3 SCN3A

6.60e-04152503ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC12A4 SCN9A

6.72e-041535039c6fce56300ba5053efda59a438d63a808c497c0
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MSANTD1 SLC18A3 SCN5A

6.98e-04155503105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SCN1A SCN2A SCN3A

6.98e-0415550377fdae85d36efb776db977eb424b32487ef222e4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MSANTD1 B3GNT4 FXR2

7.24e-0415750329622bac6b16bb39cec4319bf4c4f92d33345e8a
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN9A SCN10A TNMD

7.38e-04158503f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN9A SCN10A TNMD

7.38e-041585038c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellIPF-Epithelial-PNEC|IPF / Disease state, Lineage and Cell class

SCN2A SCN3A SLC6A5

7.51e-04159503adec82df944fe8699a69ca52534353bef100f2f9
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MSANTD1 SLC18A3 SCN5A

7.51e-041595037f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SCN2A SCN3A SV2C

7.51e-041595037747cef94c55144fddcd024a7495318357f1351b
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SCN11A SNX25 SCN1A

7.51e-041595031dde4d19cc0fde7ebbccb4c31bb845a92206021b
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN11A SNX25 SCN5A

7.79e-04161503334f540dff3508d451e5e85e8e4e8f3b8d6b74e7
ToppCellIPF-Epithelial-PNEC|World / Disease state, Lineage and Cell class

SCN2A SCN3A SLC6A5

7.79e-04161503133833729ba8b6d3eef326590ca7476b17602cbb
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN11A SNX25 SCN5A

7.79e-0416150381d44438e4be4e68a59247e62f02026301a8a0c5
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 SCN9A SCN10A

7.93e-04162503bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellIPF-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

SCN2A SCN3A SLC6A5

7.93e-04162503865d0e215d54fb1412f00cf0649c71c2f1878e57
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ANGPT1 SCN3A SCN5A

8.07e-04163503edca1d1a345109dbdeb7ee5464faefab1993fdb2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANGPT1 SLC18A3 SCN9A

8.07e-04163503ec9a20cfe0d69430f9c68cddd1ab0e4a3e4554b8
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor|lymph-node_spleen / Manually curated celltypes from each tissue

ANGPT1 SCN3A SCN9A

8.36e-041655037b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SV2A TRPC3 SCN3A

8.36e-041655039de841c1c95967c562720feba930246debc626fd
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SV2A TRPC3 SCN3A

8.36e-04165503a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDK9 B3GNT4 SCN1A

8.36e-0416550350a8513d8d2630861499393a7f102b35366bad37
DrugZonisamide

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN9A

1.92e-1517477DB00909
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN4A SCN8A SCN10A

1.80e-136475ctd:C475726
DrugSodium

SCN11A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A

4.02e-1084477ctd:D012964
Drugindoxacarb

GLA SCN3A SCN4A SCN9A SCN10A MFRP

7.27e-1049476CID000107720
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN8A SCN10A

1.11e-098474ctd:C489827
DrugAC1L1MOZ

SCN3A SCN4A SCN5A SCN9A SCN10A

2.35e-0927475CID000031958
Drugsodium

SLC12A6 SLC12A4 MTOR SLC18A3 TRPC3 SCN2A SCN3A SCN4A SCN5A SCN9A SLC6A5 SCN10A PRKCH SLC16A10

3.84e-099444714CID000000923
Drugtocainide

SCN3A SCN4A SCN5A SCN9A SCN10A

4.13e-0930475CID000038945
Drugflecainide

SCN11A SCN3A SCN4A SCN5A SCN9A SCN10A

7.19e-0971476CID000003355
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN4A SCN9A

8.24e-093473ctd:C561228
Drugpotassium

SLC12A6 SLC12A4 SV2A SCN2A SCN3A SCN4A SCN5A SCN9A SLC6A5 SCN10A SV2C PRKCH SLC12A7 SLC16A10

8.85e-0910084714CID000000813
Drugbenzocaine

SCN2A SCN3A SCN4A SCN9A SCN10A

1.25e-0837475CID000002337
Drugsipatrigine

SLC18A3 SCN2A SCN4A SCN9A SLC6A5

1.25e-0837475CID000060803
Drugtetradotoxin

SCN11A KIDINS220 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A PRKCH

1.38e-084284710CID000020382
DrugTetrodotoxin

SCN2A SCN3A SCN5A SCN8A SCN9A

1.88e-0840475ctd:D013779
DrugLidocaine

SCN5A SCN9A SCN10A

3.29e-084473DB00281
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A SCN10A

3.29e-084473ctd:C501880
Drugpilsicainide

SCN3A SCN4A SCN5A SCN9A SCN10A

3.87e-0846475CID000004820
DrugScorpion Venoms

SCN2A SCN3A SCN4A SCN9A

4.77e-0818474ctd:D012604
Drugdiprafenone

SCN3A SCN4A SCN9A SCN10A

6.04e-0819474CID000071249
Druglamotrigine

SCN2A SCN3A SCN4A SCN5A SCN9A SCN10A

1.39e-07116476CID000003878
Drugfenpropathrin

SCN2A SCN3A SCN10A

1.64e-076473ctd:C044267
DrugPotassium Chloride

SLC12A6 SLC12A4 SLC12A7

1.64e-076473DB00761
DrugMulticide

SCN2A SCN4A SCN9A TMPRSS2

1.95e-0725474CID000024365
DrugAC1NT1AF

SCN3A SCN4A SCN9A SCN10A

1.95e-0725474CID005322157
Drugsaxitoxin

SCN2A SCN3A SCN4A SCN9A SCN10A

2.27e-0765475CID000037165
DrugAC1L1CQC

SCN3A SCN4A SCN5A SCN9A SCN10A

2.27e-0765475CID000002012
DrugPirmenolum

SCN3A SCN4A SCN9A SCN10A

2.30e-0726474CID000004853
Drugmexiletine

SCN3A SCN4A SCN5A SCN9A SCN10A

2.45e-0766475CID000004178
Drugdisopyramide

SCN3A SCN4A SCN5A SCN9A SCN10A

2.45e-0766475CID000003114
DrugPbTx-1

SCN3A SCN4A SCN9A SCN10A

2.70e-0727474CID006437089
Drugnefopam

SCN3A SCN4A SCN9A SCN10A

2.70e-0727474CID000004450
Drugdibucaine

SCN3A SCN4A SCN5A SCN9A SCN10A

2.85e-0768475CID000003025
Drugparaben

SCN3A SCN4A SCN9A SCN10A

3.15e-0728474CID000007175
DrugCocaine

SCN11A SCN5A SCN10A

4.58e-078473DB00907
DrugNSC93767

SCN3A SCN4A SCN9A SCN10A

5.49e-0732474CID000005658
DrugMexiletine

SCN5A SCN9A SCN10A

6.87e-079473ctd:D008801
Drug5-hydroxypropafenone

SCN3A SCN4A SCN9A SCN10A

7.06e-0734474CID000107927
Druglidocaine

SCN3A SCN4A SCN5A SCN9A SCN10A PRKCH

9.28e-07160476CID000003676
Drugamiodarone

GLA SCN3A SCN4A SCN5A SCN9A SCN10A

9.28e-07160476CID000002156
Drugaprindine

SCN3A SCN4A SCN9A SCN10A

1.12e-0638474CID000002218
Drugranolazine

GLA SCN4A SCN5A SCN9A

1.24e-0639474CID000056959
Drugtriphosphoinositide

TRPC3 SCN3A SCN4A SCN9A SCN10A PRKCH PTK2

1.38e-06273477CID009543520
DrugS-ropivacaine

SCN3A SCN4A SCN9A SCN10A

1.38e-0640474CID000071273
Drugpropafenone

SCN3A SCN4A SCN5A SCN9A SCN10A

1.77e-0698475CID000004932
Drugcarbamazepine

SCN2A SCN3A SCN4A SCN5A SCN9A SCN10A

1.78e-06179476CID000002554
Drugtrimethoprim

FXR2 SCN3A SCN4A SCN9A SCN10A

1.86e-0699475CID000005578
DrugNSC7524

SCN2A SCN3A SCN4A SCN5A SCN9A SCN10A

1.96e-06182476CID000005657
DrugAC1NPPZW

MTOR SCN2A SCN4A SCN5A SCN9A

2.27e-06103475CID005183170
Drugspiradoline

SCN3A SCN4A SCN9A SCN10A

2.44e-0646474CID000005620
Drugprocainamide

SCN11A SCN3A SCN4A SCN5A SCN9A SCN10A

2.52e-06190476CID000004913
Druglacosamide

GLA SV2A SCN4A SCN9A

4.01e-0652474CID000219078
Drugmu-conotoxin KIIIA, Conus kinoshitai

SCN2A SCN4A

4.17e-062472ctd:C502265
DrugHexylcaine

SCN5A SCN10A

4.17e-062472DB00473
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

4.17e-062472ctd:C095651
DrugRanolazine

SCN5A SCN9A

4.17e-062472DB00243
DrugPhenytoin

SCN1A SCN5A

4.17e-062472DB00252
DrugFlecainide

SCN4A SCN5A

4.17e-062472DB01195
DrugBumetanide

SLC12A6 SLC12A4 SLC12A7

4.53e-0616473ctd:D002034
DrugAC1NSN3X

SCN3A SCN4A SCN9A SCN10A

4.67e-0654474CID005366189
Drugquindine

SCN3A SCN4A SCN5A SCN9A SCN10A TNMD

5.71e-06219476CID000001065
Drugphenytoin

SCN2A SCN3A SCN4A SCN5A SCN9A SCN10A

5.71e-06219476CID000001775
Drugbupivacaine

SCN3A SCN4A SCN9A SCN10A PRKCH

5.87e-06125475CID000002474
Drugbepridil

SCN3A SCN4A SCN5A SCN9A SCN10A

6.10e-06126475CID000002351
Drugtriamterene

SCN3A SCN4A SCN9A SCN10A

6.23e-0658474CID000005546
Drugmoricizine

SCN4A SCN5A SCN9A

6.58e-0618473CID000034632
DrugNSC611747

SLC12A6 SLC12A4 MTOR TRPC3 SCN2A PRKCH SLC12A7

7.35e-06352477CID000002534
Drugmethylglucamine

TRPC3 SCN4A SCN8A SCN9A

8.14e-0662474CID000004049
Drugzonisamide

SCN3A SCN4A SCN9A SCN10A

8.14e-0662474CID000005734
Drugresiniferatoxin

SCN3A SCN4A SCN9A SCN10A

1.05e-0566474CID000104826
DrugNOC-9

SLC12A6 SLC12A4 PTK2

1.07e-0521473CID000004524
DrugGBR 12909

SCN3A SCN4A SCN9A SCN10A

1.25e-0569474CID000003455
DrugDibucaine

SCN5A SCN10A

1.25e-053472DB00527
Drugdecamethrin

SCN1A SCN2A SCN3A SCN8A SCN10A

1.25e-05146475ctd:C017180
DrugAC1OAGFB

MTOR TRPC3 SCN3A SCN4A SCN9A SCN10A PRKCH PTK2

1.31e-05539478CID006857345
DrugT2755

SCN3A SCN4A SCN9A SCN10A

1.40e-0571474CID000005514
DrugBarium

SLC12A4 TRPC3 SLC12A7 PTK2

1.48e-0572474ctd:D001464
Drugprocaine

SCN3A SCN4A SCN9A SCN10A PRKCH

1.57e-05153475CID000004914
Drugcilengitide

GLA MTOR PTK2

1.62e-0524473CID000176873
Drug1, 3-diallylurea

SCN3A SCN4A SCN9A SCN10A

1.65e-0574474CID000074537
Drugimide

SCN3A SCN4A SCN9A SCN10A

1.65e-0574474CID000443040
Drugisofagomine

SCN4A SCN5A SCN9A SCN10A

1.74e-0575474CID000447607
Drugdiphenhydramine

SCN3A SCN4A SCN9A SCN10A

1.74e-0575474CID000003100
Drugdihydrochloride

SCN3A SCN4A SCN9A SCN10A PRKCH

1.89e-05159475CID000070978
Drugpseudococaine

SCN11A SLC18A3 SCN3A SCN4A SCN5A SCN9A SLC6A5 SCN10A

1.95e-05570478CID000002826
Drugbupropion

SCN3A SCN4A SCN9A SCN10A

2.36e-0581474CID000000444
DrugFospropofol

SCN2A SCN4A

2.50e-054472DB06716
DrugPropofol

SCN2A SCN4A

2.50e-054472DB00818
Druggabapentin

SCN3A SCN4A SCN5A SCN9A SCN10A

2.53e-05169475CID000003446
Drugencainide

SCN4A SCN5A SCN9A

2.60e-0528473CID000048040
DrugDPI 201-106

SCN4A SCN5A SCN9A

2.60e-0528473CID000005190
DrugAC1Q6DXY

KIDINS220 SLC6A5 PRKCH

2.90e-0529473CID000003719
Drugcyfluthrin

SCN2A SCN3A SCN10A

2.90e-0529473ctd:C052570
Drugriluzole

SCN3A SCN4A SCN5A SCN9A SCN10A

2.91e-05174475CID000005070
Drugtoluene

SCN3A SCN4A SCN9A SCN10A PRKCH

2.99e-05175475CID000001140
Drugoxcarbazepine

SCN4A SCN5A SCN9A

3.22e-0530473CID000034312
Drugfenfluramine

SCN3A SCN4A SCN9A SCN10A RO60

3.25e-05178475CID000003337
Drugstrychnine HCl

SCN3A SCN4A SCN9A SLC6A5 SCN10A

3.52e-05181475CID000005304
Drugchloride

SLC12A6 SLC12A4 SLC18A3 SCN2A SCN4A SLC6A5 SV2C SLC12A7 PTK2 SLC16A10

3.83e-0510294710CID000000312
DrugTrichlormethiazide

SLC12A4 SLC12A7

4.15e-055472ctd:D014237
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.90e-2510459DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

1.90e-2510459DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A

4.16e-2412459DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SLC12A6 SCN11A SLC12A4 SV2A SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC12A7

1.72e-191634513DOID:1826 (implicated_via_orthology)
DiseasePAROXYSMAL EXTREME PAIN DISORDER

SCN11A SCN9A SCN10A

3.31e-093453C1833661
DiseasePrimary Erythermalgia

SCN11A SCN9A SCN10A

3.31e-093453C0014805
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN9A

3.38e-0822454DOID:2030 (implicated_via_orthology)
DiseaseHereditary Sensory Autonomic Neuropathy, Type 5

SCN11A SCN9A SCN10A

1.16e-077453C0020075
DiseaseCongenital Pain Insensitivity

SCN11A SCN9A SCN10A

1.16e-077453C0002768
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A SCN9A

2.77e-079453C3502809
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A SCN9A

9.38e-0713453C0751122
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

2.27e-062452C4551549
DiseaseB Virus Infection

SCN8A SCN9A

6.82e-063452C0037140
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

6.82e-063452cv:C5575231
DiseasePostherpetic neuralgia

SCN8A SCN9A

6.82e-063452C0032768
DiseaseHerpesviridae Infections

SCN8A SCN9A

6.82e-063452C0019372
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A SCN8A CDC42BPB

1.25e-0593454C1535926
DiseaseBrugada ECG Pattern

SCN5A SCN10A

1.36e-054452C1721096
DiseaseCerebral Small Vessel Diseases

GLA SCN1A

2.27e-055452C2733158
DiseaseEpilepsy

SCN1A SCN2A SCN8A SCN9A

2.34e-05109454C0014544
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

3.40e-056452C0220669
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

4.75e-057452C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

4.75e-057452C0751057
Diseaseelectrocardiography, PR interval

SCN5A SCN10A

4.75e-057452EFO_0004327, EFO_0004462
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

6.33e-058452C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

6.33e-058452C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

6.33e-058452C0338479
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

6.33e-058452C0438414
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

6.33e-058452C0751120
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

6.33e-058452C0393703
DiseaseFebrile Convulsions

SCN1A SCN2A

8.13e-059452C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

8.13e-059452C0014550
Diseasesupraventricular ectopy

SCN5A SCN10A

8.13e-059452EFO_0009277
DiseaseParoxysmal atrial fibrillation

AOPEP SCN5A SCN10A PTK2

9.46e-05156454C0235480
Diseasefamilial atrial fibrillation

AOPEP SCN5A SCN10A PTK2

9.46e-05156454C3468561
DiseasePersistent atrial fibrillation

AOPEP SCN5A SCN10A PTK2

9.46e-05156454C2585653
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

1.02e-0410452C0917800
DiseaseAtrial Fibrillation

AOPEP SCN5A SCN10A PTK2

1.04e-04160454C0004238
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

1.24e-0411452C0393702
DiseaseBrugada Syndrome 1

SCN5A SCN10A

1.76e-0413452C4551804
DiseaseT wave morphology measurement

SCN5A SCN10A

2.05e-0414452EFO_0008398
DiseaseMMR-related febrile seizures

SCN1A SCN2A

2.36e-0415452EFO_0006519
DiseaseP wave duration

SCN5A SCN10A

2.36e-0415452EFO_0005094
DiseaseNeuralgia, Supraorbital

SCN9A SCN10A

2.69e-0416452C0038870
DiseaseNeuralgia, Iliohypogastric Nerve

SCN9A SCN10A

2.69e-0416452C0423712
DiseaseNeuralgia, Perineal

SCN9A SCN10A

2.69e-0416452C0423711
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

SLC18A3 SCN4A

2.69e-0416452C0751885
DiseaseNeuralgia

SCN9A SCN10A

2.69e-0416452C0027796
DiseaseRomano-Ward Syndrome

SCN5A SCN10A

2.69e-0416452C0035828
DiseaseNeuralgia, Atypical

SCN9A SCN10A

2.69e-0416452C0234247
DiseaseNeuralgia, Stump

SCN9A SCN10A

2.69e-0416452C0234249
DiseaseParoxysmal Nerve Pain

SCN9A SCN10A

2.69e-0416452C0751373
DiseaseNerve Pain

SCN9A SCN10A

2.69e-0416452C0751372
DiseaseNeuralgia, Ilioinguinal

SCN9A SCN10A

2.69e-0416452C0751371
DiseaseNeuralgia, Vidian

SCN9A SCN10A

2.69e-0416452C0042656
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

2.69e-0416452C0393706
DiseaseEpilepsy, Cryptogenic

SCN1A SCN2A SCN8A

2.70e-0482453C0086237
DiseaseAwakening Epilepsy

SCN1A SCN2A SCN8A

2.70e-0482453C0751111
DiseaseAura

SCN1A SCN2A SCN8A

2.70e-0482453C0236018
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

SLC18A3 SCN4A

3.05e-0417452C0751883
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

3.43e-0418452HP_0002373
DiseaseCongenital Myasthenic Syndromes, Presynaptic

SLC18A3 SCN4A

3.83e-0419452C0751884
DiseaseBrugada syndrome

SCN5A SCN10A

3.83e-0419452MONDO_0015263
Diseasesciatic neuropathy (implicated_via_orthology)

MTOR SCN10A

5.64e-0423452DOID:11446 (implicated_via_orthology)
DiseaseMyasthenic Syndromes, Congenital

SLC18A3 SCN4A

6.14e-0424452C0751882
DiseaseBrugada Syndrome (disorder)

SCN5A SCN10A

6.14e-0424452C1142166
DiseaseBipolar Disorder

SLC12A6 ABCA13 TRPC3 SCN2A SCN8A

7.75e-04477455C0005586
Diseaselung small cell carcinoma (is_implicated_in)

MTOR PTK2

8.38e-0428452DOID:5409 (is_implicated_in)
Diseasecardiovascular age measurement

SCN5A SCN10A

8.99e-0429452EFO_0803380
DiseasePR interval

SCN5A SCN10A SV2C SLC12A7 PTK2

9.15e-04495455EFO_0004462
Diseasesocial communication impairment

SCN11A SCN10A

1.10e-0332452EFO_0005427
DiseaseLarge cell carcinoma of lung

MTOR CDC42BPB

1.10e-0332452C0345958
Diseaseheart function measurement

SCN5A SCN10A

1.24e-0334452EFO_0004311

Protein segments in the cluster

PeptideGeneStartEntry
MWMAWCVAALSVVAV

BPIFB4

1

P59827
EQGGMTFGWVCWMIL

ABCA13

3746

Q86UQ4
TMGWLHWERFMCNLD

GLA

41

P06280
MCKCALMLTGGWWFD

ANGPT1

436

Q15389
IAVGCWTEMKMETWS

AOPEP

341

Q8N6M6
GGCKGVQWMCDMWRD

MFRP

431

Q9BY79
VQWMCDMWRDCTDGS

MFRP

436

Q9BY79
WTDAEMRGLMLVWEE

MSANTD1

46

Q6ZTZ1
CLWMAIGSWMSGVPV

OR10A7

141

Q8NGE5
NLEHRDMGGWTALMW

KIDINS220

96

Q9ULH0
DMGGWTALMWACYKG

KIDINS220

101

Q9ULH0
MMDCTWTLPGMRATW

PSMG3-AS1

1

Q96PY0
PCGWWLARVRMMKGD

FXR2

86

P51116
GGCWMDVWELMSQEC

GGNBP2

176

Q9H3C7
GMRFWVCLAACRAMW

CELF2-AS1

66

Q8N7Q2
MLRMRTAGWARGWCL

PCDH7

1

O60245
TMWNPWIAMCLLGLS

MFSD1

351

Q9H3U5
ECDWWSLGVCMYEML

CDC42BPB

261

Q9Y5S2
GMMDLAYVCEWEKWS

MED16

11

Q9Y2X0
MEDAGMYWCRVAEWQ

CD101

901

Q93033
MWTMWALVTDEGLKC

B3GNT4

356

Q9C0J1
DLWGAGCIMAEMWTR

CDK9

211

P50750
IDVWWIVHDGGMLML

SLC12A6

911

Q9UHW9
IDVWWIVHDGGMLML

SLC12A7

846

Q9Y666
ENFWMVWSEAMARGC

PRAMEF26

16

H0Y7S4
WGLGQWDSMEEYTCM

MTOR

1521

P42345
MEMGAAKVWGEVGRW

PEX16

96

Q9Y5Y5
AASEWEMGMAWLPAF

SLC18A3

321

Q16572
GEHLSWLCMFWMIGG

SV2C

276

Q496J9
RILCGEWIETMWDCM

SCN4A

756

P35499
EWIETMWDCMEVAGQ

SCN4A

761

P35499
PNWSMVLGWLMLACS

SLC6A5

711

Q9Y345
HMARTDWWCENLGMW

SNX25

496

Q9H3E2
SASDVWMFGVCMWEI

PTK2

601

Q05397
CENFWMVWSEAMARG

PRAMEF25

111

A6NGN4
CGEWIETMWDCMEVS

SCN5A

896

Q14524
GEWIETMWDCMEVAG

SCN9A

926

Q15858
CENFWMVWSEAMARG

PRAMEF27

111

A3QJZ7
CGEWIETMWDCMEVA

SCN3A

941

Q9NY46
CGMWGRALRKAIADW

RO60

141

P10155
IDVWWIVHDGGMLML

SLC12A4

846

Q9UP95
EHLSWLCMFWMIGGV

SV2A

291

Q7L0J3
RVLCGEWIETMWDCM

SCN1A

946

P35498
EWIETMWDCMEVAGQ

SCN1A

951

P35498
SMWDMETGDRRFTLW

PIK3R4

1211

Q99570
RVIMPCNWWVARMLG

TNMD

301

Q9H2S6
MMLQPEQLCWISGWG

TMPRSS2

371

O15393
LCGEWIENMWACMEV

SCN10A

846

Q9Y5Y9
GEWIETMWDCMEVAG

SCN2A

941

Q99250
RVLCGEWIETMWDCM

SCN8A

931

Q9UQD0
EWIETMWDCMEVAGQ

SCN8A

936

Q9UQD0
CGEWIENMWECMQEA

SCN11A

766

Q9UI33
VWVLGMMWSECKELW

TRPC3

431

Q13507
MMWSECKELWLEGPR

TRPC3

436

Q13507
EGGWGWLVMLAAMWC

SLC16A10

66

Q8TF71
DWWAMGVLLYEMLCG

PRKCH

536

P24723