Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

EPRS1 TARS3 VARS1

1.49e-0442493GO:0016875
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

EPRS1 TARS3 VARS1

1.49e-0442493GO:0004812
GeneOntologyCellularComponentimmunological synapse

HLA-DRA PRKCQ IL4I1

2.20e-0449503GO:0001772
GeneOntologyCellularComponentmyofibril

CAPN3 DNAJB4 TNNC1 ABLIM2 RYR3

4.80e-04273505GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

CAPN3 DNAJB4 TNNC1 ABLIM2 RYR3

6.31e-04290505GO:0043292
DomainHGTP_anticodon

EPRS1 TARS3

2.30e-049482PF03129
Domainaa-tRNA-synt_IIb

EPRS1 TARS3

3.51e-0411482IPR002314
DomaintRNA-synt_2b

EPRS1 TARS3

3.51e-0411482PF00587
Domain-

EPRS1 TARS3

3.51e-04114823.40.50.800
DomainAnticodon-bd

EPRS1 TARS3

5.77e-0414482IPR004154
Domainaa-tRNA-synth_I_CS

EPRS1 VARS1

9.64e-0418482IPR001412
Domainaa-tRNA-synth_II

EPRS1 TARS3

9.64e-0418482IPR006195
DomainAA_TRNA_LIGASE_II

EPRS1 TARS3

9.64e-0418482PS50862
DomainAA_TRNA_LIGASE_I

EPRS1 VARS1

1.08e-0319482PS00178
DomainGST_C

EPRS1 VARS1

2.02e-0326482IPR004046
DomainGST_C

EPRS1 VARS1

2.02e-0326482PF00043
DomainHECT

HACE1 HECTD1

2.18e-0327482PF00632
DomainHECTc

HACE1 HECTD1

2.18e-0327482SM00119
DomainHECT_dom

HACE1 HECTD1

2.18e-0327482IPR000569
DomainHECT

HACE1 HECTD1

2.18e-0327482PS50237
DomainThioredoxin

TUSC3 NME8

2.87e-0331482PF00085
DomainEF-hand_8

CAPN3 TNNC1

3.44e-0334482PF13833
DomainPkinase_C

RPS6KA5 PRKCQ

4.07e-0337482IPR017892
DomainGlutathione-S-Trfase_C-like

EPRS1 VARS1

4.51e-0339482IPR010987
Domain-

EPRS1 VARS1

4.51e-03394821.20.1050.10
DomainThioredoxin_domain

TUSC3 NME8

4.98e-0341482IPR013766
DomainPkinase_C

RPS6KA5 PRKCQ

5.22e-0342482PF00433
DomainRossmann-like_a/b/a_fold

EPRS1 VARS1

5.46e-0343482IPR014729
Domain-

EPRS1 VARS1

5.46e-03434823.40.50.620
PathwayWP_MFAP5MEDIATED_OVARIAN_CANCER_CELL_MOTILITY_AND_INVASIVENESS

PRKCQ TNNC1 RYR3

7.40e-0613433M39463
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

EPRS1 TARS3 XRN2 LDB1 ZNF473 HLA-DRA KIF1B MCF2L2 PKM LRP2 MAP3K10 TLN2 ZNFX1 HECTD1 VARS1 RYR3

1.66e-111285501635914814
Pubmed

Intestinal epithelial cells secrete exosome-like vesicles.

STX3 HLA-DRA PKM

4.85e-062350311487543
Pubmed

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells.

TLN2 PRKCQ

6.07e-06350218792400
Pubmed

The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.

MAP3K10 MAP3K4

6.07e-06350223760366
Pubmed

CD4 raft association and signaling regulate molecular clustering at the immunological synapse site.

TLN2 PRKCQ

1.21e-05450215128768
Pubmed

Vesicular transport and kidney development.

STX3 LRP2

1.21e-05450210535319
Pubmed

Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex.

EPRS1 TARS3

2.02e-05550224312579
Pubmed

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR.

HACE1 MAP3K4

3.03e-05650236038948
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

EPRS1 ACADL PITPNM3 PKM MAP3K10 TLN2 ZNFX1 NACAD VARS1

3.14e-05113950936417873
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CUL4B EPRS1 XRN2 PKM DNAJB4 HECTD1 VARS1

3.41e-0563850733239621
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

HACE1 MCF2L2 ZNFX1 HECTD1

3.76e-0513050412421765
Pubmed

Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.

CUL4B SHPRH

4.23e-05750223555860
Pubmed

Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes.

KLHL30 PCDH12

5.64e-05850218246200
Pubmed

Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development.

STX3 LRP2

9.05e-051050210469351
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

CUL4B EPRS1 XRN2 RPS6KA5 KIF1B TLN2 PRDM2

1.14e-0477450715302935
Pubmed

A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.

ACADL PKM TNNC1

1.20e-046650332212902
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

EPRS1 TARS3 ACADL KIF1B PKM TLN2 ZNFX1 ABLIM2 VARS1

1.80e-04143150937142655
Pubmed

MAP3Ks as central regulators of cell fate during development.

MAP3K10 MAP3K4

2.10e-041550218855897
Pubmed

High-throughput RNAi screening reveals novel regulators of telomerase.

PRKCQ MAP3K4

2.40e-041650221531765
Pubmed

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

HACE1 PKM HECTD1

2.81e-048850327182664
Pubmed

LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.

LRP2 TNNC1

3.05e-041850232901292
Pubmed

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.

HLA-DRA PKM

3.05e-041850212519789
Pubmed

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.

EPRS1 XRN2 PKM DNAJB4

3.73e-0423650436339263
Pubmed

Immunomic analysis of human sarcoma.

ARHGAP24 AUTS2

4.18e-042150212601173
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

KIF1B CAPN3 SHPRH HECTD1

4.99e-0425550415324660
Pubmed

High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.

EPRS1 XRN2 PKM ZNFX1 VARS1

5.61e-0446950537314180
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CUL4B RPS6KA5 CAPN3 LRP2 PRKCQ TAF1L

6.07e-0473050634857952
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

EPRS1 PITPNM3 PKM LRP2 PIDD1 PRDM2

6.33e-0473650629676528
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HACE1 HECTD1

6.44e-042650226949039
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

KIF1B CAPN3 PKM PCDH12 ABLIM2

7.29e-0449750523414517
Pubmed

Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.

HLA-DRA GRAP2

7.48e-042850217652306
Pubmed

Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice.

STX3 AUTS2

8.02e-042950221909369
Pubmed

Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy.

EPRS1 PKM

8.59e-043050235152003
Pubmed

The mechanism of phospholipase C-gamma1 regulation.

HLA-DRA GRAP2

9.17e-043150211048639
Pubmed

Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.

ACADL PKM LRP2

9.19e-0413250322496890
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

CRELD1 PIDD1 HECTD1 VARS1

1.19e-0332250426514267
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

STX3 LDB1 KIF1B TUSC3 SHPRH AUTS2 ABLIM2 HECTD1

1.20e-03148950828611215
Pubmed

TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.

CUL4B DNAJB4

1.31e-033750229531219
Pubmed

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

HLA-DRA PRKCQ

1.31e-033750219430480
GeneFamilyAminoacyl tRNA synthetases, Class I

EPRS1 VARS1

6.10e-0419352131
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K10 MAP3K4

9.78e-0424352654
CoexpressionGSE37563_WT_VS_CTLA4_KO_CD4_TCELL_D4_POST_IMMUNIZATION_UP

KIF1B LAPTM4B GRAP2 SHPRH DNAJB4

1.61e-05166505M9015
CoexpressionGSE7400_CTRL_VS_CSF3_IN_VIVO_TREATED_PBMC_DN

XRN2 KIF1B CAPN3 TLN2 NME8

3.76e-05198505M5670
CoexpressionGSE24142_DN2_VS_DN3_THYMOCYTE_FETAL_DN

ARHGAP24 CAPN3 GRAP2 DNAJB4 PRKCQ

3.85e-05199505M4575
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

STX3 RPS6KA5 GRAP2 RYR3

2.90e-05157504ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCellFetal_29-31_weeks-Immune-mast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRAP2 MCF2L2 RAD9B IL4I1

2.97e-051585040c27c475289c70b17b6a66fc71f628511c5f0ae1
ToppCellMild-MAIT|World / Disease group and Cell class

CRELD1 ABLIM2 IL4I1 FHIP1A

3.44e-0516450421dc02997dfae73cf70ce291661928526605dba1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STX3 RPS6KA5 GRAP2 RYR3

3.44e-051645042c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF473 TNNC1 NACAD VARS1

3.69e-05167504b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCellCOVID-19-lung-MAST|lung / Disease (COVID-19 only), tissue and cell type

STX3 RPS6KA5 GRAP2 RYR3

3.96e-05170504e90f18e5462381b38e918442b38b1c8105291908
ToppCell3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STX3 GRAP2 NME8 RYR3

4.05e-051715045885e69e997cc2f6a27afebfe57001ca0ac062a6
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

STX3 RPS6KA5 GRAP2 RYR3

4.14e-051725046e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAP2 PRKCQ TNNC1 MAP3K4

4.73e-05178504f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LAPTM4B LRP2 PRKCQ RYR3

5.05e-05181504ee207ea171e2ffc22a7f850be57bb118a87e0f81
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

ACADL LRP2 AUTS2 FHIP1A

5.27e-051835048e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ACADL LRP2 PRKCQ FHIP1A

5.61e-05186504bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ACADL LRP2 PRKCQ FHIP1A

5.73e-05187504db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP24 AUTS2 PRKCQ FHIP1A

5.85e-051885044bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STX3 RPS6KA5 GRAP2 RYR3

6.35e-05192504758ca0dacf313787effda36e6d1adb809e5b3a4e
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

ACADL LRP2 AUTS2 FHIP1A

6.35e-0519250458c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ACADL LRP2 AUTS2 FHIP1A

6.48e-05193504fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

CUL4B EPRS1 KIF1B HECTD1

6.48e-05193504abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ACADL LRP2 AUTS2 FHIP1A

6.48e-05193504f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP24 HLA-DRA AUTS2 PRDM2

6.61e-051945045cd72330c9d9bb21b6c9d5d35085eade101486d1
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STX3 RPS6KA5 GRAP2 RYR3

6.74e-05195504fbedb9978ded857fd35c2a8664f7579f42edaa36
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STX3 RPS6KA5 GRAP2 RYR3

6.74e-05195504f1f48e2e57b2282572959b152aad4bee05143f03
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STX3 RPS6KA5 GRAP2 RYR3

6.88e-05196504e08f90f7a923c2846cac859519b8dc7c0ac7cd03
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

STX3 RPS6KA5 GRAP2 RYR3

7.01e-0519750461f909737c5f630beffdd326c6844215643dbdde
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

STX3 RPS6KA5 GRAP2 RYR3

7.15e-051985042e6630eab77b12a6059682ab5ba465f38e469102
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ACADL LRP2 AUTS2 FHIP1A

7.15e-05198504f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellParenchymal-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STX3 RPS6KA5 GRAP2 RYR3

7.44e-052005049156f8fd61a833891d2f7b7fadd693b81b1e2d5a
ToppCellParenchymal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STX3 RPS6KA5 GRAP2 RYR3

7.44e-05200504566fe2e78e6f35399ec6aad5964f6d4d8ade82c6
ToppCellmild-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KLHL30 MCF2L2 AUTS2 NME8

7.44e-05200504ca0a08bf162c954f037a56aa0cbb8b5d7c6ffec0
ToppCellCOVID_vent-Lymphocytic-T_cell-Gamma_Delta_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

PITPNM3 AUTS2 IL4I1

4.37e-04132503dbc0a332fd8f63ebdcf9716e45d7f46f26509349
ToppCell10x5'-blood-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|blood / Manually curated celltypes from each tissue

AUTS2 TNNC1 NACAD

4.77e-04136503f024015bf60e64b8657e410e24995a1edec85196
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP2 TLN2 FHIP1A

5.64e-041445031b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

STX3 GRAP2 RYR3

5.87e-04146503f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LRP2 FHIP1A NME8

5.87e-04146503bee5074c29b132180d35f57d307e342efa9b8cd1
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MCF2L2 PITPNM3 ANKS4B

6.10e-041485031186ee0d15244fee74c1d09df3967c1b69f8ddce
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF473 PRKCQ ABLIM2

6.10e-0414850380470353e12599440f711b6e107730763376d04d
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF473 NACAD VARS1

6.22e-04149503f18bddc84b064f3d57a1281d5172c404d87f25da
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STX3 RPS6KA5 GRAP2

6.47e-04151503f5ae450e3daa10540ca8437d05efe2d86ac70960
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma|TCGA-Uterus / Sample_Type by Project: Shred V9

EPRS1 ACADL RPS6KA5

6.47e-041515032810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCellTCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

ADH6 LRP2 ANKS4B

6.85e-0415450389a60a79d07466d7ad05888d10a72d3b1ab384af
ToppCellTCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

ADH6 LRP2 ANKS4B

6.85e-04154503f1fea1a87e977221fa125b62287368be9af4987d
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-midbrain/hindbrain_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ARHGAP24 PIDD1 RYR3

6.85e-04154503df1b58a20af73fa79c6c069c0117a9ffd85b476f
ToppCell10x5'-Liver-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Liver / Manually curated celltypes from each tissue

RPS6KA5 HACE1 MAP3K4

6.85e-04154503c6308074468235c88ef4ea43ab155d9f86cbf261
ToppCellTCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

ADH6 LRP2 ANKS4B

6.85e-04154503b5604c0b0b9b283352a3f612f40883b9123475d1
ToppCellTCGA-Bone_and_Soft_Tissue-Solid_Tissue_Normal-Connective_tissue_normal-Connective_tissue_normal-1|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

ADH6 LRP2 ANKS4B

6.85e-04154503160b170a3ade8b246843c9854af332475c047ba0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC91 ABLIM2 RYR3

6.98e-0415550390e629681a72baacc7981b82883866a487638dbc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC91 ABLIM2 RYR3

6.98e-04155503e7f49e2fdaf184fa6b4e685518004e7deff1316d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC91 ABLIM2 RYR3

6.98e-041555035a872ca70ae8c30b57f45a6772d7bf565e0c2663
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

STX3 GRAP2 RYR3

7.11e-04156503bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

STX3 GRAP2 RYR3

7.11e-04156503159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF473 TNNC1 NACAD

7.24e-04157503432b8719a8afd289cf48068e12c26a349d753fcc
ToppCellPCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-im_megakaryocyte1_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GRAP2 ANKS4B RYR3

7.38e-04158503944c5fe625f965dd6153dbcbf5577f99ad343983
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Undetermined|normal_Pleural_Fluid / Location, Cell class and cell subclass

ARHGAP24 HLA-DRA PRDM2

7.65e-041605035744cd30709f38e84f7ec8893dc19d7a288b465a
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAPN3 GRAP2 PRKCQ

7.79e-0416150352556b89808e551540f33a13f57417a6696c2438
ToppCellMild-MAIT|Mild / Disease group and Cell class

ABLIM2 IL4I1 FHIP1A

7.79e-041615030c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAPN3 GRAP2 PRKCQ

7.79e-0416150354f156cf2bd5a6ba9a78ec4e3ee28b89998aec2e
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAPN3 GRAP2 PRKCQ

7.79e-04161503242891be849a4398fe8bea44875ae1ba57950944
ToppCell10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_memory|bone_marrow / Manually curated celltypes from each tissue

ARHGAP24 HLA-DRA PRDM2

8.22e-04164503746833f74095c0f25ce76baf1069f1848c231933
ToppCellInfluenza_Severe-cDC|World / Disease group and Cell class

RAD9B TLN2 RYR3

8.22e-04164503c984228f73b9aa1aaf948541f64f41ed874770cd
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HLA-DRA PCDH12 IL4I1

8.36e-0416550360b500eb2c10cccf309b8fb28a9119da22d6889c
ToppCelltumor_Lung-B_lymphocytes-Undetermined|tumor_Lung / Location, Cell class and cell subclass

ARHGAP24 HLA-DRA PRDM2

8.36e-041655033d010a66abac3961cc99f20b1459cf0eb0f7510d
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPS6KA5 GRAP2 RYR3

8.36e-0416550337615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPS6KA5 GRAP2 RYR3

8.36e-04165503640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RPS6KA5 GRAP2 RYR3

8.36e-04165503f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|368C / Donor, Lineage, Cell class and subclass (all cells)

TUSC3 HACE1 PCDH12

8.51e-0416650330a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|368C / Donor, Lineage, Cell class and subclass (all cells)

TUSC3 HACE1 PCDH12

8.51e-0416650376b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCellwk_20-22-Hematologic-Myeloid-Mast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

STX3 RPS6KA5 GRAP2

8.51e-04166503004ab6a1425d812c7ce572205875fd702d4a9659
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STX3 RPS6KA5 GRAP2

8.66e-041675030aa1973141a2437df24c9857cd50ff3dfc7673c0
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HLA-DRA RAD9B IL4I1

8.81e-04168503eba865465feb0f42055bb8f98946050eeb03d177
ToppCell367C-Lymphocytic-B_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP24 HLA-DRA PRDM2

8.81e-041685031943ae24ff90218b8c2c10b4102b5007ae35fc85
ToppCellControl|World / group, cell type (main and fine annotations)

ACADL LRP2 FHIP1A

8.81e-04168503a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell367C-Lymphocytic-B_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

ARHGAP24 HLA-DRA PRDM2

8.81e-04168503f4414d462d35abd00e3c1446302d7060f8a48d48
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC91 ABLIM2 RYR3

8.81e-04168503e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCellTracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IL4I1 FHIP1A NME8

8.81e-04168503c34dd4a9c54d8e9c8f118e6a3816548890cb0746
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKCQ PCDH12 ABLIM2

8.96e-04169503f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARHGAP24 HLA-DRA PRDM2

8.96e-04169503c3a6179a64589a370108fea809b157839347759c
ToppCellfacs-Heart-RA-24m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAP2 IL4I1 VARS1

8.96e-04169503dcf92121fb00e3b6498e2648363e90ac044ea396
ToppCellNS-critical-d_0-4-Myeloid-Monocyte-derived_DC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

HLA-DRA TLN2 NME8

8.96e-041695036fe82db874eff0f86e5c0d1cc81322eb9d7874eb
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

STX3 GRAP2 RYR3

8.96e-04169503fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l5|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRAP2 PIDD1 PRKCQ

8.96e-041695031de3ae36d3b60e961bfd9f7bdc37867b82a0417f
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKCQ PCDH12 ABLIM2

9.12e-0417050335e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF473 KLHL30 AUTS2

9.12e-04170503d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL30 AUTS2 TNNC1

9.12e-04170503cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKCQ PCDH12 ABLIM2

9.12e-041705030ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

GRAP2 SHPRH LRP2

9.12e-041705034a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRKCQ PCDH12 ABLIM2

9.12e-041705030b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL30 AUTS2 TNNC1

9.12e-04170503da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

STX3 GRAP2 RYR3

9.12e-04170503c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC91 GRAP2 PRKCQ

9.27e-04171503539ea88acc6f948efdeae8b69e5c5ffaee29f1d9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP24 HLA-DRA PRDM2

9.27e-04171503a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRAP2 PRKCQ RYR3

9.27e-04171503b2e753e811a7639956994609f73efcdb62d04f82
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

LDB1 PIDD1 TLN2

9.43e-04172503c6bc78fd63c9479a84ec0552b55c89750cad0fa5
ToppCellLPS-IL1RA-Lymphocytic_NKT-T_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC91 GRAP2 PRKCQ

9.43e-041725030fc692be845d4225ff8b63bf9195724fc8510c2c
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

LDB1 PIDD1 TLN2

9.43e-04172503bfb87a281a9cf6ad45b310bf8104fc0ab382b549
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ARHGAP24 HLA-DRA PRDM2

9.43e-0417250362ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPS6KA5 GRAP2 NME8

9.43e-041725032ab720a4c96073339a1f8b95ec7699682df98acf
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_atypical|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ARHGAP24 HLA-DRA PRDM2

9.59e-04173503f135cc9dcf34f33ced3210171ab40ae6d77cfae0
ToppCellsevere-B_memory|severe / disease stage, cell group and cell class

ARHGAP24 HLA-DRA PRDM2

9.59e-041735033a987ac53a0136cc4c70ce8b901a15fc00c795e1
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRKCQ ABLIM2 RYR3

9.59e-041735039dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP24 IL4I1 NACAD

9.59e-04173503e944ea3a0a368f856efacbda4600605cf751dd9c
Diseasemicroglial activation measurement

ARHGAP24 RPS6KA5 AUTS2

1.31e-0459493EFO_0010940
Diseaseautoimmune thyroiditis (is_implicated_in)

HLA-DRA LRP2

1.76e-0412492DOID:7188 (is_implicated_in)
Diseasebullous pemphigoid

HLA-DRA TNNC1

1.46e-0334492EFO_0007187
Diseasetotal hip arthroplasty, osteoarthritis

TLN2 TNNC1

2.23e-0342492EFO_0009806, MONDO_0005178
DiseaseMultiple Sclerosis

HLA-DRA KIF1B

2.56e-0345492C0026769
DiseaseMultiple Sclerosis, Acute Fulminating

HLA-DRA KIF1B

2.56e-0345492C0751324
Diseasegrip strength measurement

HLA-DRA KIF1B AUTS2 DNAJB4

2.71e-03350494EFO_0006941
DiseaseNeuroblastoma

KIF1B HACE1

2.78e-0347492C0027819

Protein segments in the cluster

PeptideGeneStartEntry
ADVAISASEFMFEET

ACADL

296

P28330
FDMTDAGIDFCFEAI

ADH6

256

P28332
EFQEVFGMSIEEFDR

ABLIM2

581

Q6H8Q1
EEMAGFEFQVIAEDS

PCDH12

526

Q9NPG4
MFAGDFAESFSARVE

KLHL30

61

Q0D2K2
VHSEMFVGSDEFDFF

RAD9B

201

Q6WBX8
EFDFFQIGMDTEITF

RAD9B

211

Q6WBX8
SAGFFSEMTEDELVV

CRELD1

351

Q96HD1
SDTKDMNEFETEGFF

PRKCQ

126

Q04759
FASLNEMEEFAEAED

MAP3K10

606

Q02779
DAFTTEFFEDDAMLT

LDB1

91

Q86U70
MEDFDDEAFVDDAGS

KIF1B

931

O60333
EFSSMDTFEDCEGAE

MCF2L2

1011

Q86YR7
LTFSVETDVFGAMEE

HACE1

706

Q8IYU2
DIIDGFAMTSFVTFE

AUTS2

86

Q8WXX7
FSSSELGGDFEFMDD

LAPTM4B

146

Q86VI4
FGVEQDVDMVFASFI

PKM

231

P14618
FTETSAVFEDGTMFE

FMO6P

306

O60774
AVFEDGTMFEAIDSV

FMO6P

311

O60774
DELDVSNFAEEFTEM

RPS6KA5

341

O75582
IDFDAQDSTIFFSDM

LRP2

746

P98164
MEVFREEEEDSFSGD

ANKS4B

231

Q8N8V4
EMEQFFSTFGELTVE

ARHGAP24

721

Q8N264
DSEEMEIDGDPFSAF

DNAJB4

121

Q9UDY4
DEEDDFDSFIAEMPA

FHIP1A

806

Q05DH4
AIDTGAFEVNFMDDV

HECTD1

381

Q9ULT8
MDDDDFGGFEAAETF

CCDC91

1

Q7Z6B0
EFMFDFDGDEIFHVD

HLA-DRA

46

P01903
MEAVAKFDFTASGED

GRAP2

1

O75791
EAMEDFTGGVAEFFE

CAPN3

226

P20807
EFVGFDAKMAEESSS

CUL4B

126

Q13620
FAEVDEDGGTFMDVL

CEBPZ

911

Q03701
TKEEANGDVFETFMF

PRDM2

346

Q13029
PSDTVEMFEGEEFFA

PIDD1

656

Q9HB75
EMFEGEEFFAAFERG

PIDD1

661

Q9HB75
DVMSEDGFFYLSFAE

IL4I1

231

Q96RQ9
MFTSEFDAEVDESES

MAP3K4

1011

Q9Y6R4
VSSEFFEEGFMADVD

TARS3

716

A2RTX5
VFDEFVDMDFGTGAV

VARS1

576

P26640
FIEGADAETFSEGEM

EPRS1

551

P07814
SFFAPEEENEEDFQM

TAF1L

926

Q8IZX4
EFVDEGSTSMDLFEA

SHPRH

1316

Q149N8
IDNTAFMDEFFSEIE

STX3

26

Q13277
LFFSMVDYDEGTDVF

TUSC3

126

Q13454
DQCDFEEFVSFMTSG

NME8

206

Q8N427
SFNDEEEEEAMVFFV

RYR3

4451

Q15413
FASDFEGIADMPSDF

XRN2

571

Q9H0D6
SDDEFFDAREEMAEG

PITPNM3

31

Q9BZ71
HMDEVTQIFFGFEDE

ZNFX1

1566

Q9P2E3
FSDDFDEFLDAGIEM

TLN2

1276

Q9Y4G6
EDGSGTVDFDEFLVM

TNNC1

66

P63316
MEDFFEEGFSQEIIE

ZNF473

86

Q8WTR7
TEGMDEAFAFRDDTS

NACAD

371

O15069