Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	MI	EIF4G3 EIF4G1	8.46e-05	6	45	2	PS51366
Domain	MA3	EIF4G3 EIF4G1	8.46e-05	6	45	2	SM00544
Domain	MA3	EIF4G3 EIF4G1	8.46e-05	6	45	2	PF02847
Domain	Initiation_fac_eIF4g_MI	EIF4G3 EIF4G1	8.46e-05	6	45	2	IPR003891
Domain	W2	EIF4G3 EIF4G1	1.18e-04	7	45	2	PF02020
Domain	W2	EIF4G3 EIF4G1	1.18e-04	7	45	2	PS51363
Domain	eIF5C	EIF4G3 EIF4G1	1.18e-04	7	45	2	SM00515
Domain	W2_domain	EIF4G3 EIF4G1	1.18e-04	7	45	2	IPR003307
Domain	ARM-type_fold	PPP2R5D EIF4G3 HGH1 PIK3C2A RPTOR EIF4G1	1.53e-04	339	45	6	IPR016024
Domain	MIF4G	EIF4G3 EIF4G1	2.52e-04	10	45	2	SM00543
Domain	MIF4G	EIF4G3 EIF4G1	2.52e-04	10	45	2	PF02854
Domain	MIF4G-like_typ-3	EIF4G3 EIF4G1	2.52e-04	10	45	2	IPR003890
Domain	MIF4-like	EIF4G3 EIF4G1	5.84e-04	15	45	2	IPR016021
Domain	-	EIF4G3 EIF4G1	5.84e-04	15	45	2	1.25.40.180
Domain	PX	PIK3C2A NISCH	5.04e-03	44	45	2	SM00312
Domain	PX	PIK3C2A NISCH	6.21e-03	49	45	2	PF00787
Domain	PX	PIK3C2A NISCH	6.46e-03	50	45	2	PS50195
Domain	-	PIK3C2A NISCH	6.71e-03	51	45	2	3.30.1520.10
Domain	Phox	PIK3C2A NISCH	6.97e-03	52	45	2	IPR001683
Domain	HEAT	EIF4G3 RPTOR	8.61e-03	58	45	2	IPR000357
Pubmed	eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.	EIF4G3 RPTOR EIF4G1	4.61e-08	6	47	3	18426977
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LMF2 PPP2R5D METTL16 EIF4G3 HGH1 RPTOR NISCH EIF4G1 SPTLC1 NUP88	4.23e-07	942	47	10	31073040
Pubmed	eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.	EIF4G3 EIF4G1	1.79e-06	2	47	2	10872469
Pubmed	Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.	EIF4G3 EIF4G1	1.79e-06	2	47	2	31999954
Pubmed	Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.	EIF4G3 EIF4G1	5.36e-06	3	47	2	20212144
Pubmed	A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.	EIF4G3 EIF4G1	5.36e-06	3	47	2	9857202
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PPP2R5D TUBGCP4 MED23 RPTOR IFT81 EIF4G1 NUP88	9.73e-06	560	47	7	35241646
Pubmed	Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.	RNF213 RPTOR	1.07e-05	4	47	2	25053281
Pubmed	Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.	EIF4G3 EIF4G1	1.07e-05	4	47	2	21191102
Pubmed	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	EIF4G3 EIF4G1	1.78e-05	5	47	2	19239892
Pubmed	The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine.	SLC9A2 SLC26A6	1.78e-05	5	47	2	24233434
Pubmed	A novel functional human eukaryotic translation initiation factor 4G.	EIF4G3 EIF4G1	1.78e-05	5	47	2	9418880
Pubmed	Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.	EIF4G3 EIF4G1	1.78e-05	5	47	2	9878069
Pubmed	Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.	RPTOR EIF4G1	2.67e-05	6	47	2	18955708
Pubmed	Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo.	SLC9A2 SLC26A6	2.67e-05	6	47	2	24018950
Pubmed	Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.	EIF4G3 EIF4G1	2.67e-05	6	47	2	10022874
Pubmed	IL-1β-activated mTORC2 promotes accumulation of IFN-γ+ γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis.	CXCR3 RPTOR	3.74e-05	7	47	2	35361750
Pubmed	Familial pure proximal renal tubular acidosis--a clinical and genetic study.	SLC9A2 SLC26A6	6.40e-05	9	47	2	17881426
Pubmed	eIF4G is required for the pioneer round of translation in mammalian cells.	EIF4G3 EIF4G1	6.40e-05	9	47	2	15361857
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	TUBGCP4 EIF4G3 HGH1 RPTOR SPTLC1 NUP88	6.57e-05	515	47	6	31617661
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	EIF4G3 PIK3C2A NISCH EIF4G1	1.62e-04	202	47	4	24639526
Pubmed	The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.	EIF4G3 EIF4G1	2.12e-04	16	47	2	37307456
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MED23 USP15 NISCH TRMT61A NUP88	3.14e-04	440	47	5	34244565
Pubmed	A quantitative atlas of mitotic phosphorylation.	RNF213 HGH1	3.34e-04	20	47	2	18669648
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RNF213 ANKH ANO8	3.51e-04	101	47	3	10997877
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	PPP2R5D TUBGCP4 USP15 RPTOR SYDE1 NISCH IFT81 NUP88	3.56e-04	1321	47	8	27173435
Pubmed	NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity.	CERS2 SPTLC1	4.06e-04	22	47	2	38303107
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	EIF4G3 EIF4G1 NUP88	5.54e-04	118	47	3	30979931
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EIF4G3 USP15 RPTOR EIF4G1 NUP88	5.77e-04	503	47	5	16964243
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS2 SPTLC1	6.14e-04	27	47	2	23096701
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	CERS2 SPTLC1	6.14e-04	27	47	2	25269881
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	EIF4G3 EIF4G1 NUP88	6.25e-04	123	47	3	26912792
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PPP2R5D EIF4G3 RETREG2 USP15 RPTOR ANO8 NUP88	7.94e-04	1139	47	7	36417873
Pubmed	Defining the membrane proteome of NK cells.	CERS2 RNF213 LMF2 TUBGCP4 PIK3C2A NISCH EIF4G1	9.20e-04	1168	47	7	19946888
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DENND1B EIF4G3 PIK3C2A RPTOR SYDE1 EIF4G1	1.02e-03	861	47	6	36931259
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CERS2 LMF2 PPP2R5D MED23 RPTOR EIF4G1 SPTLC1	1.09e-03	1203	47	7	29180619
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	RNF213 PPP2R5D BAZ2A NUP88	1.16e-03	341	47	4	32971831
Pubmed	The sequence of the human genome.	CFAP47 RNF213 DENND1B DNAH17 TRMT61A	1.30e-03	603	47	5	11181995
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	CERS2 RNF213 MINDY2 USP15 SYDE1	1.31e-03	604	47	5	38803224
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	LMF2 PPP2R5D NISCH	1.34e-03	160	47	3	31678930
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	RPTOR CDON	1.35e-03	40	47	2	34677125
Cytoband	17q25.3	RNF213 GALR2 RPTOR DNAH17	3.66e-06	101	47	4	17q25.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	RNF213 GALR2 RPTOR DNAH17	2.79e-04	307	47	4	chr17q25
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HMCN2 CDON	2.39e-02	161	27	2	593
Disease	migraine disorder, systolic blood pressure	KCNK5 RNF213	3.27e-04	18	44	2	EFO_0006335, MONDO_0005277
Disease	cigarettes per day measurement	DENND1B MED23 EIF4G3 MINDY2 CHRNB2	4.75e-04	438	44	5	EFO_0006525
Disease	Moyamoya disease	RNF213 RPTOR	1.64e-03	40	44	2	MONDO_0016820
Disease	kidney disease (implicated_via_orthology)	CUBN KLB	1.72e-03	41	44	2	DOID:557 (implicated_via_orthology)
Disease	bipolar disorder, schizophrenia	PIK3C2A SPTLC1	1.80e-03	42	44	2	MONDO_0004985, MONDO_0005090
Disease	urate measurement	CERS2 KCNK5 CUBN MINDY2 NISCH KLB	2.02e-03	895	44	6	EFO_0004531
Disease	blood phosphate measurement	MED23 EIF4G3 ANKH	2.23e-03	174	44	3	EFO_0010972
Disease	health study participation	DENND1B RPTOR TRMT61A	3.08e-03	195	44	3	EFO_0010130
Disease	hip bone mineral density, hip bone size	TMEM260 NUP88	3.18e-03	56	44	2	EFO_0004844, EFO_0007702
Disease	response to efavirenz, virologic response measurement	PIK3C2A IFT81	3.41e-03	58	44	2	EFO_0006904, EFO_0006906
Disease	Headache	RNF213 IFT81	4.13e-03	64	44	2	HP_0002315
Disease	hip bone size	TMEM260 NUP88	4.26e-03	65	44	2	EFO_0004844

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCWTPYHLVVLVDIL	CXCR3	266	P49682
YLREPLWPTHEVVLE	BAZ2A	1601	Q9UIF9
PTLEAAWPHLQLVYE	PPP2R5D	201	Q14738
PFWILHCTLVYPLEL	CERS2	281	Q96G23
LKYLIHVAIPDIPGW	ANO8	856	Q9HCE9
GEDWLHYELLVLTPP	HMCN2	2836	Q8NDA2
VLYLLPKAHTVPTWP	ERVV-1	196	B6SEH8
FIVWGVLVHLVIPPF	KCNK5	166	O95279
LHQWPALYPLIALEL	PIK3C2A	931	O00443
LIITALPEPYWIVLH	MED23	1151	Q9ULK4
LPEPYWIVLHDRIVS	MED23	1156	Q9ULK4
IPTVPLRLNYIHWVE	METTL16	76	Q86W50
WPLHILFTPAVLEKY	TUBGCP4	461	Q9UGJ1
LQAIPLSVDLWIHYI	PRPF39	156	Q86UA1
LPLVIPYSQVWIHFV	CUBN	2656	O60494
WHPEAVIVPLLFALI	GALR2	21	O43603
VIGSKPVIYPVLHWL	IFT81	91	Q8WYA0
PVIYPVLHWLLQRTN	IFT81	96	Q8WYA0
LLQTVWHYEVPELLP	C16orf96	276	A6NNT2
FWIPYIHNLKVPIPI	DNAH17	3381	Q9UFH2
LPVPVIRWYDSHGLI	CDON	431	Q4KMG0
ALTHYWPLIRFLVPL	ANKH	6	Q9HCJ1
IDIPHVWLYLAELVT	EIF4G1	1331	Q04637
NIEPIVTLYHWDLPL	KLB	186	Q86Z14
WQHIYIPVLPPHLLD	DENND1B	241	Q6P3S1
EIQAIHWIYPIVGLP	CFAP47	2876	Q6ZTR5
IDIPHIWLYLAELVT	EIF4G3	1311	O43432
SLWLLEPASYHVVPI	INAVA	361	Q3KP66
AYLILRELHSWEPEP	HGH1	311	Q9BTY7
AAWYPSEILDPHVVL	NUP88	176	Q99567
VISIPLYIPHTLFEW	HRH4	66	Q9H3N8
LDIPLYHGWLVDPQI	MINDY2	361	Q8NBR6
EVLHYLLQSWPDPRL	SYDE1	591	Q6ZW31
IHVLGTLWYLPPLIV	TAS2R3	181	Q9NYW6
SPLRHPVIYLLLWAA	LMF2	96	Q9BU23
LLQHLPVLVWLPRYP	SLC26A6	71	Q9BXS9
SILLWPLVVYHELIQ	RETREG2	216	Q8NC44
IWRVLLHLAADPYPE	RPTOR	811	Q8N122
PAYHLILEGILILWI	SPTLC1	21	O15269
RLPSKHIWLPDVVLY	CHRNB2	106	P17787
IHRYIPFILWPISDL	CMTM2	136	Q8TAZ6
YRVHALPPSLIPLVW	RNF213	2566	Q63HN8
PHVQIPFEITLWILL	SLC9A2	76	Q9UBY0
TLPWHSLILRPQYEI	THEMIS2	196	Q5TEJ8
VYVLHPTPELWTLNL	TRMT61A	66	Q96FX7
IPYWLLLTPQHLNVI	NISCH	906	Q9Y2I1
KLDLWSLPPVLVVHL	USP15	821	Q9Y4E8
IPLLPHSWKYIAYVV	ZDHHC11B	61	P0C7U3
HTIILYVLCIIPWIL	TMEM260	191	Q9NX78