Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	6-phosphofructo-2-kinase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	7.00e-12	4	34	4	GO:0003873
GeneOntologyMolecularFunction	fructose-2,6-bisphosphate 2-phosphatase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.50e-11	5	34	4	GO:0004331
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.44e-10	7	34	4	GO:0008443
GeneOntologyMolecularFunction	sugar-phosphatase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.46e-09	10	34	4	GO:0050308
GeneOntologyMolecularFunction	carbohydrate phosphatase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.29e-09	11	34	4	GO:0019203
GeneOntologyMolecularFunction	carbohydrate kinase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	4.11e-08	21	34	4	GO:0019200
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	DAPK1 PFKFB1 PFKFB2 PFKFB3 PFKFB4 POLR3A CDS2	8.72e-04	938	34	7	GO:0016772
GeneOntologyMolecularFunction	phosphatase activity	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.38e-03	287	34	4	GO:0016791
GeneOntologyBiologicalProcess	fructose 2,6-bisphosphate metabolic process	PFKFB1 PFKFB2 PFKFB3 PFKFB4	6.25e-11	6	31	4	GO:0006003
GeneOntologyBiologicalProcess	fructose metabolic process	PFKFB1 PFKFB2 PFKFB3 PFKFB4	7.50e-09	16	31	4	GO:0006000
GeneOntologyBiologicalProcess	carbohydrate phosphorylation	PFKFB1 PFKFB2 PFKFB3 PFKFB4	5.16e-08	25	31	4	GO:0046835
GeneOntologyBiologicalProcess	hexose metabolic process	TKTL1 PFKFB1 PFKFB2 PFKFB3 PFKFB4	6.05e-05	284	31	5	GO:0019318
GeneOntologyBiologicalProcess	monosaccharide metabolic process	TKTL1 PFKFB1 PFKFB2 PFKFB3 PFKFB4	9.15e-05	310	31	5	GO:0005996
GeneOntologyBiologicalProcess	carbohydrate catabolic process	TKTL1 PFKFB1 PFKFB2 PFKFB3	2.04e-04	196	31	4	GO:0016052
GeneOntologyBiologicalProcess	RNA 3'-end processing	INTS2 INTS7 VIRMA	4.24e-04	98	31	3	GO:0031123
GeneOntologyBiologicalProcess	snRNA 3'-end processing	INTS2 INTS7	5.42e-04	23	31	2	GO:0034472
GeneOntologyBiologicalProcess	glycolytic process	PFKFB1 PFKFB2 PFKFB3	5.95e-04	110	31	3	GO:0006096
GeneOntologyBiologicalProcess	detection of stimulus	OR52I2 OR1B1 OR51Q1 OR6C2 FFAR4 CDS2	6.27e-04	722	31	6	GO:0051606
GeneOntologyBiologicalProcess	ADP catabolic process	PFKFB1 PFKFB2 PFKFB3	6.60e-04	114	31	3	GO:0046032
GeneOntologyBiologicalProcess	purine nucleoside diphosphate catabolic process	PFKFB1 PFKFB2 PFKFB3	7.12e-04	117	31	3	GO:0009137
GeneOntologyBiologicalProcess	purine ribonucleoside diphosphate catabolic process	PFKFB1 PFKFB2 PFKFB3	7.12e-04	117	31	3	GO:0009181
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR52I2 OR1B1 OR51Q1 OR6C2 FFAR4	7.22e-04	485	31	5	GO:0050907
GeneOntologyBiologicalProcess	pyridine nucleotide catabolic process	PFKFB1 PFKFB2 PFKFB3	7.48e-04	119	31	3	GO:0019364
GeneOntologyBiologicalProcess	ADP metabolic process	PFKFB1 PFKFB2 PFKFB3	7.66e-04	120	31	3	GO:0046031
GeneOntologyBiologicalProcess	ribonucleoside diphosphate catabolic process	PFKFB1 PFKFB2 PFKFB3	7.85e-04	121	31	3	GO:0009191
GeneOntologyBiologicalProcess	pyridine-containing compound catabolic process	PFKFB1 PFKFB2 PFKFB3	8.23e-04	123	31	3	GO:0072526
GeneOntologyBiologicalProcess	nucleoside diphosphate catabolic process	PFKFB1 PFKFB2 PFKFB3	8.43e-04	124	31	3	GO:0009134
GeneOntologyBiologicalProcess	snRNA processing	INTS2 INTS7	8.65e-04	29	31	2	GO:0016180
GeneOntologyBiologicalProcess	purine nucleoside diphosphate metabolic process	PFKFB1 PFKFB2 PFKFB3	1.01e-03	132	31	3	GO:0009135
GeneOntologyBiologicalProcess	purine ribonucleoside diphosphate metabolic process	PFKFB1 PFKFB2 PFKFB3	1.01e-03	132	31	3	GO:0009179
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR52I2 OR1B1 OR51Q1 OR6C2 FFAR4	1.02e-03	524	31	5	GO:0009593
GeneOntologyBiologicalProcess	glucose catabolic process	TKTL1 PFKFB2	1.05e-03	32	31	2	GO:0006007
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR52I2 OR1B1 OR51Q1 OR6C2 FFAR4	1.24e-03	547	31	5	GO:0007606
GeneOntologyBiologicalProcess	pyruvate metabolic process	PFKFB1 PFKFB2 PFKFB3	1.25e-03	142	31	3	GO:0006090
GeneOntologyBiologicalProcess	ribonucleoside diphosphate metabolic process	PFKFB1 PFKFB2 PFKFB3	1.27e-03	143	31	3	GO:0009185
GeneOntologyBiologicalProcess	nucleoside diphosphate metabolic process	PFKFB1 PFKFB2 PFKFB3	1.43e-03	149	31	3	GO:0009132
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR52I2 OR1B1 OR51Q1 OR6C2 FFAR4	1.63e-03	582	31	5	GO:0050906
GeneOntologyBiologicalProcess	purine ribonucleotide catabolic process	PFKFB1 PFKFB2 PFKFB3	2.05e-03	169	31	3	GO:0009154
GeneOntologyBiologicalProcess	ribonucleotide catabolic process	PFKFB1 PFKFB2 PFKFB3	2.38e-03	178	31	3	GO:0009261
GeneOntologyBiologicalProcess	purine nucleotide catabolic process	PFKFB1 PFKFB2 PFKFB3	2.53e-03	182	31	3	GO:0006195
GeneOntologyBiologicalProcess	carbohydrate metabolic process	TKTL1 PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.57e-03	646	31	5	GO:0005975
GeneOntologyBiologicalProcess	purine-containing compound catabolic process	PFKFB1 PFKFB2 PFKFB3	2.78e-03	188	31	3	GO:0072523
GeneOntologyBiologicalProcess	hexose catabolic process	TKTL1 PFKFB2	2.87e-03	53	31	2	GO:0019320
GeneOntologyBiologicalProcess	monosaccharide catabolic process	TKTL1 PFKFB2	3.31e-03	57	31	2	GO:0046365
GeneOntologyBiologicalProcess	pyridine nucleotide metabolic process	PFKFB1 PFKFB2 PFKFB3	3.40e-03	202	31	3	GO:0019362
GeneOntologyBiologicalProcess	nicotinamide nucleotide metabolic process	PFKFB1 PFKFB2 PFKFB3	3.40e-03	202	31	3	GO:0046496
Domain	6Phosfructo_kin	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.03e-11	4	35	4	IPR013079
Domain	6PF2K	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.03e-11	4	35	4	PF01591
Domain	6Pfruct_kin	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.03e-11	4	35	4	IPR003094
Domain	PG/BPGM_mutase_AS	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.29e-09	9	35	4	IPR001345
Domain	PGAM	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.15e-09	10	35	4	SM00855
Domain	PG_MUTASE	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.15e-09	10	35	4	PS00175
Domain	His_Pase_superF_clade-1	PFKFB1 PFKFB2 PFKFB3 PFKFB4	5.06e-09	12	35	4	IPR013078
Domain	His_Phos_1	PFKFB1 PFKFB2 PFKFB3 PFKFB4	5.06e-09	12	35	4	PF00300
Domain	His_PPase_superfam	PFKFB1 PFKFB2 PFKFB3 PFKFB4	4.90e-08	20	35	4	IPR029033
Domain	-	PFKFB1 PFKFB2 PFKFB3 PFKFB4	4.90e-08	20	35	4	3.40.50.1240
Domain	GPCR_Rhodpsn_7TM	OR52I2 GPR22 OR1B1 OR51Q1 OR6C2 FFAR4	1.39e-03	670	35	6	IPR017452
Domain	7tm_1	OR52I2 GPR22 OR1B1 OR51Q1 OR6C2 FFAR4	1.47e-03	677	35	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR52I2 GPR22 OR1B1 OR51Q1 OR6C2 FFAR4	1.56e-03	685	35	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR52I2 GPR22 OR1B1 OR51Q1 OR6C2 FFAR4	1.63e-03	691	35	6	PS50262
Domain	GPCR_Rhodpsn	OR52I2 GPR22 OR1B1 OR51Q1 OR6C2 FFAR4	1.64e-03	692	35	6	IPR000276
Domain	CYCLIN	RBL1 CCNC	2.30e-03	38	35	2	SM00385
Domain	-	RBL1 CCNC	2.54e-03	40	35	2	1.10.472.10
Domain	Cyclin-like	RBL1 CCNC	2.94e-03	43	35	2	IPR013763
Domain	Olfact_rcpt	OR52I2 OR1B1 OR51Q1 OR6C2	6.04e-03	393	35	4	IPR000725
Pathway	REACTOME_REGULATION_OF_GLYCOLYSIS_BY_FRUCTOSE_2_6_BISPHOSPHATE_METABOLISM	PFKFB1 PFKFB2 PFKFB3 PFKFB4	7.07e-09	12	29	4	M27950
Pathway	KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM	PFKFB1 PFKFB2 PFKFB3 PFKFB4	6.42e-07	34	29	4	M15898
Pathway	REACTOME_GLUCOSE_METABOLISM	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.26e-05	82	29	4	MM15394
Pathway	REACTOME_GLUCOSE_METABOLISM	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.61e-05	85	29	4	M1870
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	ZFYVE9 RBL1 CCNC	5.17e-04	77	29	3	MM14670
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	ZFYVE9 RBL1 CCNC	9.25e-04	94	29	3	M1041
Pubmed	Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines.	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.59e-13	4	35	4	9464277
Pubmed	6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.59e-13	4	35	4	7574501
Pubmed	Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.59e-13	4	35	4	10095107
Pubmed	Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase.	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.59e-13	4	35	4	2837207
Pubmed	The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate.	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.00e-11	7	35	4	15896703
Pubmed	Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.08e-10	9	35	4	21074528
Pubmed	Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.	PFKFB2 PFKFB3 PFKFB4	9.34e-10	3	35	3	14623077
Pubmed	Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia.	PFKFB2 PFKFB3 PFKFB4	9.34e-10	3	35	3	30819197
Pubmed	PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma.	PFKFB2 PFKFB3 PFKFB4	5.21e-08	8	35	3	36115843
Pubmed	Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain.	PFKFB2 PFKFB3	9.84e-07	2	35	2	17991424
Pubmed	Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain.	PFKFB2 PFKFB3	9.84e-07	2	35	2	11245921
Pubmed	Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.	PFKFB1 PFKFB2	9.84e-07	2	35	2	15331593
Pubmed	Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	PFKFB1 PFKFB2	9.84e-07	2	35	2	8814283
Pubmed	Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors.	PFKFB2 PFKFB4	9.84e-07	2	35	2	15925437
Pubmed	Loss of PFKFB4 induces cell death in mitotically arrested ovarian cancer cells.	PFKFB3 PFKFB4	9.84e-07	2	35	2	28152500
Pubmed	Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation.	PFKFB3 PFKFB4	9.84e-07	2	35	2	16311927
Pubmed	Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells.	PFKFB2 PFKFB3	9.84e-07	2	35	2	38813509
Pubmed	Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta.	PFKFB3 PFKFB4	9.84e-07	2	35	2	8830046
Pubmed	Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.	PFKFB3 PFKFB4	2.95e-06	3	35	2	17143338
Pubmed	Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	PFKFB1 PFKFB2	2.95e-06	3	35	2	9202079
Pubmed	Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis.	PFKFB2 PFKFB3 PFKFB4	4.12e-06	31	35	3	36127325
Pubmed	[EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA].	PFKFB3 PFKFB4	5.90e-06	4	35	2	27491149
Pubmed	[EXPRESSION OF GENES, WHICH CONTROL GLUCOSE METABOLISM, IN BLOOD CELLS OF THE OBESE BOYS WITH INSULIN RESISTANCE].	PFKFB1 PFKFB3	5.90e-06	4	35	2	26827442
Pubmed	Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.	PFKFB1 PFKFB2	5.90e-06	4	35	2	11522786
Pubmed	Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands.	RHBDF1 TGFA	9.82e-06	5	35	2	15965977
Pubmed	A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.	PFKFB2 PFKFB3	9.82e-06	5	35	2	18039179
Pubmed	Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.	PFKFB3 PFKFB4	4.40e-05	10	35	2	25974097
Pubmed	Streamlined analysis schema for high-throughput identification of endogenous protein complexes.	INTS2 INTS7 CCNC	5.09e-05	71	35	3	20133760
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	PFKFB3 MAGT1 FAM120A	5.31e-05	72	35	3	33106477
Pubmed	Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.	INTS2 INTS7	5.38e-05	11	35	2	23904267
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A4 TKTL1	6.45e-05	12	35	2	19419973
Pubmed	Structure of the catalytic core of the Integrator complex.	INTS2 INTS7	8.89e-05	14	35	2	33548203
Pubmed	The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.	INTS2 INTS7	8.89e-05	14	35	2	32697989
Pubmed	INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.	INTS2 INTS7	8.89e-05	14	35	2	32647223
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	INTS2 INTS7 VIRMA CDS2	1.01e-04	242	35	4	34011540
Pubmed	The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.	INTS2 INTS7	2.91e-04	25	35	2	34004147
Pubmed	Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.	INTS2 INTS7	3.15e-04	26	35	2	33298525
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52I2 OR1B1 OR51Q1 OR6C2	3.70e-04	340	35	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52I2 OR1B1 OR51Q1 OR6C2	3.70e-04	340	35	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52I2 OR1B1 OR51Q1 OR6C2	3.82e-04	343	35	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52I2 OR1B1 OR51Q1 OR6C2	3.95e-04	346	35	4	14611657
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NCAPD3 MAGT1 RHBDF1 INTS2 INTS7 VIRMA CCNC	6.29e-04	1497	35	7	31527615
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	DAPK1 CD82 MAGT1 RBL1 CDS2	7.23e-04	719	35	5	35337019
Pubmed	Defining the membrane proteome of NK cells.	NCAPD3 MAGT1 FAM120A INTS2 POLR3A CDS2	9.98e-04	1168	35	6	19946888
Interaction	PFKFB3 interactions	PFKFB1 PFKFB2 PFKFB3 PFKFB4 VIRMA	4.66e-08	67	30	5	int:PFKFB3
Interaction	PFKFB4 interactions	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.84e-07	38	30	4	int:PFKFB4
Interaction	PFKFB2 interactions	PFKFB2 PFKFB3 PFKFB4 VIRMA	2.10e-06	62	30	4	int:PFKFB2
Interaction	PFKFB1 interactions	PFKFB1 PFKFB3 PFKFB4	7.56e-06	26	30	3	int:PFKFB1
Interaction	PPP2R1A interactions	DAPK1 NCAPD3 ZFYVE9 INTS2 INTS7 VIRMA POLR3A	4.33e-05	665	30	7	int:PPP2R1A
Interaction	DDR2 interactions	MAGT1 ZFYVE9 FAM120A VIRMA	4.74e-05	136	30	4	int:DDR2
Interaction	INTS3 interactions	INTS2 INTS7 VIRMA CDS2	6.60e-05	148	30	4	int:INTS3
Interaction	LDLRAD4 interactions	NCAPD3 MAGT1 VIRMA	9.15e-05	59	30	3	int:LDLRAD4
Interaction	JHY interactions	DAPK1 VIRMA	9.57e-05	10	30	2	int:JHY
GeneFamily	6-phosphofructo-2-kinases/fructose-2,6-biphosphatases	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.36e-12	4	26	4	1077
GeneFamily	Integrator complex	INTS2 INTS7	2.06e-04	15	26	2	1366
Coexpression	STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_DN	IPP DAPK1 CDS2	4.10e-06	25	33	3	M2104
Computational	Membranal receptors.	DAPK1 CD82 PFKFB1 PFKFB3 PFKFB4 TGFA	1.36e-04	517	18	6	MODULE_64
Drug	glipentide	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.63e-10	7	35	4	CID000065779
Drug	2-MP	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.26e-10	8	35	4	CID003015569
Drug	fructose 2-phosphorothioate 6-phosphate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.53e-09	11	35	4	CID000195184
Drug	carboxytolbutamide	PFKFB1 PFKFB2 PFKFB3 PFKFB4	4.63e-09	14	35	4	CID000159651
Drug	PK-F	PFKFB1 PFKFB2 PFKFB3 PFKFB4	4.63e-09	14	35	4	CID000448133
Drug	Thr-Ala	PFKFB1 PFKFB2 PFKFB3 PFKFB4	6.31e-09	15	35	4	CID006427021
Drug	dibenzyl succinate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.40e-09	16	35	4	CID000007653
Drug	N-bromoacetylethanolamine phosphate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.10e-08	17	35	4	CID000188343
Drug	AC1L1AO2	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.41e-08	18	35	4	CID000001073
Drug	brazilin	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.41e-08	18	35	4	CID000073384
Drug	melarsen oxide	PFKFB1 PFKFB2 PFKFB3 PFKFB4	4.86e-08	24	35	4	CID000030830
Drug	mitiglinide	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.01e-08	27	35	4	CID000121891
Drug	mantATP	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.37e-07	35	35	4	CID000123756
Drug	AC1Q6RZ4	TKTL1 PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.21e-06	123	35	5	CID000000719
Drug	3-phosphohistidine	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.74e-06	57	35	4	CID000123911
Drug	1,6-di-o-phosphonohexopyranose	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.78e-06	64	35	4	CID000000737
Drug	AC1L19C4	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.77e-06	69	35	4	CID000000483
Drug	AC1NDZBW	PFKFB1 PFKFB2 PFKFB3 PFKFB4 TGFA	9.42e-06	187	35	5	CID004634040
Drug	2-hexulofuranose	PFKFB1 PFKFB2 PFKFB3 PFKFB4	9.95e-06	88	35	4	CID000000716
Drug	Cochliobolic acid	RHBDF1 TGFA	3.43e-05	6	35	2	CID006450172
Drug	SSFSB	RHBDF1 TGFA	4.80e-05	7	35	2	CID003035734
Drug	glyceraldehyde	PFKFB1 PFKFB2 PFKFB3 PFKFB4	6.18e-05	140	35	4	CID000000751
Drug	1 sulfonylurea	PFKFB1 PFKFB2 PFKFB3 PFKFB4	6.71e-05	143	35	4	CID011819083
Drug	fructose-1,6-diphosphate sodium salt	PFKFB1 PFKFB2 PFKFB3 PFKFB4	8.29e-05	151	35	4	CID000000718
Drug	H 661	RHBDF1 TGFA	1.03e-04	10	35	2	CID003056529
Drug	allulose 6-phosphate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	1.09e-04	162	35	4	CID000000603
Drug	4,5-dianilinophthalimide	RHBDF1 TGFA	1.25e-04	11	35	2	CID000001697
Drug	troglitazone	UGT1A4 PFKFB1 PFKFB2 PFKFB3 PFKFB4 CCNC	1.36e-04	526	35	6	CID000005591
Drug	AC1L9JR2	RHBDF1 TGFA	1.77e-04	13	35	2	CID000446506
Drug	Lidocaine	RBL1 CCNC TGFA	1.92e-04	73	35	3	ctd:D008012
Drug	wartmannin	PFKFB1 PFKFB2 PFKFB3 PFKFB4 ZFYVE9 RHBDF1 TGFA	1.99e-04	811	35	7	CID000005691
Drug	CoCl2	PFKFB2 PFKFB3 PFKFB4	2.08e-04	75	35	3	CID003015678
Drug	ara-Hx	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.13e-04	193	35	4	CID000000804
Drug	Gleevec; Up 200; 10uM; MCF7; HG-U133A	TLN2 PFKFB1 PFKFB2 TGFA	2.26e-04	196	35	4	366_UP
Drug	Meropenem [96036-03-2]; Down 200; 10.4uM; HL60; HT_HG-U133A	CD82 ZFYVE9 RHBDF1 CDS2	2.26e-04	196	35	4	6141_DN
Drug	glucose-6-P	TKTL1 PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.28e-04	366	35	5	CID000000208
Drug	(1)-Nipecotic acid [498-95-3]; Down 200; 31uM; MCF7; HT_HG-U133A	CD82 ZFYVE9 INTS7 RBL1	2.31e-04	197	35	4	5999_DN
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; HL60; HT_HG-U133A	DAPK1 PFKFB2 ZFYVE9 TGFA	2.31e-04	197	35	4	2361_UP
Drug	Ketorolac tromethamine [74103-07-4]; Up 200; 10.6uM; HL60; HT_HG-U133A	DAPK1 MAU2 PFKFB2 ZFYVE9	2.35e-04	198	35	4	3110_UP
Drug	Tridihexethyl chloride; Down 200; 11.4uM; PC3; HT_HG-U133A	TLN2 CD82 PFKFB2 TGFA	2.35e-04	198	35	4	5067_DN
Drug	tolbutamide	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.35e-04	198	35	4	CID000005505
Drug	phosphoenolpyruvate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	2.94e-04	210	35	4	CID000001005
Drug	Phosphoryl	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.22e-04	215	35	4	CID006857426
Drug	benzoate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.57e-04	221	35	4	CID000000242
Drug	S-adenosyl-D-homocysteine	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.63e-04	222	35	4	CID000000193
Drug	glycerol-3-phosphate	PFKFB1 PFKFB2 PFKFB3 PFKFB4	3.89e-04	226	35	4	CID000000754
Disease	triacylglycerol 58:8 measurement	MAU2 TGFA	7.05e-04	35	33	2	EFO_0010442
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	DAPK1 PFKFB3	8.76e-04	39	33	2	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	mean reticulocyte volume	TLN2 CD82 MAU2 PFKFB1 RBL1	1.82e-03	799	33	5	EFO_0010701
Disease	Cleft palate	MAU2 VIRMA	2.87e-03	71	33	2	HP_0000175
Disease	citrate measurement	PFKFB2 PFKFB3	3.54e-03	79	33	2	EFO_0010114
Disease	osteoarthritis, hip	TLN2 TGFA	4.77e-03	92	33	2	EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENVLVICHQAVMRCL	PFKFB1	386	P16118
VLVISHQAVMRCLLA	PFKFB2	386	O60825
IALHLAVRRCQMEVI	DAPK1	546	P53355
IIVMCVQIKCFHEII	CDS2	96	O95674
IIAAQMCHTDLCRLL	ANKRD24	186	Q8TF21
IELLGMVLSICLCRH	CD82	241	P27701
VVIMNNRVCTLLVLC	OR6C2	131	Q9NZP2
RILMCHCLAAIAMQL	INTS7	446	Q9NVH2
MLQLTEVVHLCCEFL	IPP	116	Q9Y573
MIALACLHVACVVQQ	CCNC	196	P24863
LVMNHQRCACLLALS	OR1B1	136	Q8NGR6
CLIELVNCQMVLRGA	KIAA0100	1576	Q14667
VMFTALQLHRQCVVC	MAGT1	76	Q9H0U3
AVSLERMVCIVHLQR	FFAR4	131	Q5NUL3
CLHQDMIRLVCADIR	OR51Q1	181	Q8NH59
ENVLVICHQAVLRCL	PFKFB3	381	Q16875
VLVICHQAVMRCLLA	PFKFB4	386	Q16877
CHCIERTVIEIINMS	INTS2	1186	Q9H0H0
PVCMAHCIRLALIRF	FAM120A	141	Q9NZB2
ANVPTHLMVLCCVLR	FAM120A	706	Q9NZB2
TMNLHVLDVIICVGC	GPR22	81	Q99680
QVILLEHIIMCRLVT	MAU2	336	Q9Y6X3
MCQQILRDCILLIHH	OR52I2	1	Q8NH67
VCTILIVAMIVLHAC	TMEM150B	161	A6NC51
IFHRSLMACCLEIVL	RBL1	496	P28749
ILHCLVSICFQMTVL	RHBDF1	666	Q96CC6
VIGILQMICKTCCHI	POLR3A	101	O14802
TVHCMVILLNCAQHL	SLC36A3	86	Q495N2
AVRNNVIIVMCDLCI	NCAPD3	956	P42695
MGLRNILKVCCTHDI	C12orf4	451	Q9NQ89
LAVLIITCVLIHCCQ	TGFA	111	P01135
MVALSLKICVRHCNV	TLN2	1	Q9Y4G6
HEQRIQGLLCDCMLV	ZBTB49	16	Q6ZSB9
QPIQHMLRRICVQLC	VIRMA	1171	Q69YN4
LLALCETVVRVLMHQ	WDR87	171	Q6ZQQ6
ISARHIIVAVKCMLL	TKTL1	581	P51854
EARVCVICHSVLMNA	ZFYVE9	746	O95405
IMNNVSLALHRCCVE	UGT1A4	116	P22310