Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF823 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 H2AZ1 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	3.72e-13	1459	48	22	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF823 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	2.10e-12	1412	48	21	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF771 ZEB1 ZNF48 ZNF569 ZKSCAN3 ZNF790 ZNF267 H2AZ1 ZNF778 ZNF470 ZNF784 ZNF730 ZNF181 ZFP62	8.03e-07	1244	48	14	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF771 ZEB1 ZNF48 ZNF569 ZKSCAN3 ZNF790 ZNF267 H2AZ1 ZNF778 ZNF470 ZNF784 ZNF730 ZNF181 ZFP62	1.04e-06	1271	48	14	GO:0000987
Domain	-	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	3.04e-19	679	49	22	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	4.85e-19	694	49	22	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	5.07e-18	775	49	22	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	5.36e-18	777	49	22	PS00028
Domain	Znf_C2H2-like	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	8.94e-18	796	49	22	IPR015880
Domain	zf-C2H2	ZNF823 ZNF462 ZNF771 ZNF672 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	9.91e-18	693	49	21	PF00096
Domain	Znf_C2H2	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	1.13e-17	805	49	22	IPR007087
Domain	ZnF_C2H2	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	1.23e-17	808	49	22	SM00355
Domain	zf-C2H2_6	ZNF823 ZNF771 ZNF672 ZNF48 ZNF266 ZNF569 ZNF846 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF730 ZNF181 ZFP62	1.63e-15	314	49	15	PF13912
Domain	KRAB	ZNF823 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF730 ZNF181	1.13e-14	358	49	15	PS50805
Domain	KRAB	ZNF823 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF730 ZNF181	1.76e-14	369	49	15	SM00349
Domain	KRAB	ZNF823 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF730 ZNF181	1.83e-14	370	49	15	IPR001909
Domain	KRAB	ZNF823 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF730 ZNF181	2.58e-13	358	49	14	PF01352
Domain	ZnF_BED	ZNF266 ZNF846 ZNF181	2.76e-06	11	49	3	SM00614
Domain	Znf_BED	ZNF266 ZNF846 ZNF181	3.67e-06	12	49	3	IPR003656
Domain	zf-H2C2_2	ZNF846 ZNF778	6.01e-04	14	49	2	PF13465
Domain	Histone_H2A_CS	H2AZ2 H2AZ1	6.93e-04	15	49	2	IPR032458
Domain	MAM_1	TMPRSS15 MAMDC4	7.90e-04	16	49	2	PS00740
Domain	Histone_H2A_C	H2AZ2 H2AZ1	8.94e-04	17	49	2	IPR032454
Domain	Histone_H2A_C	H2AZ2 H2AZ1	8.94e-04	17	49	2	PF16211
Domain	MAM	TMPRSS15 MAMDC4	8.94e-04	17	49	2	SM00137
Domain	MAM	TMPRSS15 MAMDC4	1.00e-03	18	49	2	PF00629
Domain	MAM_dom	TMPRSS15 MAMDC4	1.00e-03	18	49	2	IPR000998
Domain	MAM_2	TMPRSS15 MAMDC4	1.00e-03	18	49	2	PS50060
Domain	HISTONE_H2A	H2AZ2 H2AZ1	1.37e-03	21	49	2	PS00046
Domain	H2A	H2AZ2 H2AZ1	1.65e-03	23	49	2	SM00414
Domain	Histone_H2A	H2AZ2 H2AZ1	1.65e-03	23	49	2	IPR002119
Domain	LDLR_class-A_CS	TMPRSS15 MAMDC4	4.94e-03	40	49	2	IPR023415
Domain	Ldl_recept_a	TMPRSS15 MAMDC4	6.21e-03	45	49	2	PF00057
Domain	-	TMPRSS15 MAMDC4	6.48e-03	46	49	2	4.10.400.10
Domain	LDLRA_1	TMPRSS15 MAMDC4	7.04e-03	48	49	2	PS01209
Domain	LDrepeatLR_classA_rpt	TMPRSS15 MAMDC4	7.33e-03	49	49	2	IPR002172
Domain	LDLa	TMPRSS15 MAMDC4	7.33e-03	49	49	2	SM00192
Domain	LDLRA_2	TMPRSS15 MAMDC4	7.33e-03	49	49	2	PS50068
Domain	Histone	H2AZ2 H2AZ1	9.49e-03	56	49	2	PF00125
Domain	Histone_H2A/H2B/H3	H2AZ2 H2AZ1	9.49e-03	56	49	2	IPR007125
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF771 ZNF266 H2AZ2 ZNF337 ZNF569 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF730 AXIN1	5.16e-06	1387	37	14	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF569 ZNF558 ZNF267 ZNF778 ZNF799 ZNF57 ZNF181	7.61e-09	181	50	7	37372979
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF569 ZKSCAN3 ZNF778 ZFP62	7.63e-07	49	50	4	9630514
Pubmed	H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.	H2AZ2 H2AZ1	2.03e-06	2	50	2	32266374
Pubmed	Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.	H2AZ2 H2AZ1	2.03e-06	2	50	2	32916283
Pubmed	Sex-specific effects of the histone variant H2A.Z on fear memory, stress-enhanced fear learning and hypersensitivity to pain.	H2AZ2 H2AZ1	2.03e-06	2	50	2	32868857
Pubmed	The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken.	H2AZ2 H2AZ1	2.03e-06	2	50	2	16204459
Pubmed	Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates.	H2AZ2 H2AZ1	2.03e-06	2	50	2	20003410
Pubmed	Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification.	H2AZ2 H2AZ1	2.03e-06	2	50	2	38366138
Pubmed	H2A.Z facilitates licensing and activation of early replication origins.	H2AZ2 H2AZ1	2.03e-06	2	50	2	31875854
Pubmed	Characterization and mapping of human genes encoding zinc finger proteins.	ZNF48 ZNF569 ZNF57	4.22e-06	22	50	3	1946370
Pubmed	Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.	ZNF48 ZNF569 ZNF57	4.22e-06	22	50	3	1505991
Pubmed	Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.	H2AZ2 H2AZ1	6.07e-06	3	50	2	34525369
Pubmed	Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers.	H2AZ2 H2AZ1	6.07e-06	3	50	2	32694618
Pubmed	The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis.	H2AZ2 H2AZ1	6.07e-06	3	50	2	31015444
Pubmed	Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain.	H2AZ2 H2AZ1	6.07e-06	3	50	2	38091994
Pubmed	Identification and characterization of the two isoforms of the vertebrate H2A.Z histone variant.	H2AZ2 H2AZ1	6.07e-06	3	50	2	20299344
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	ZEB1 H2AZ2 AXIN1	6.29e-06	25	50	3	29475039
Pubmed	Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.	ARHGEF4 AXIN1	1.21e-05	4	50	2	17588722
Pubmed	Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.	H2AZ2 H2AZ1	2.02e-05	5	50	2	35072799
Pubmed	Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.	H2AZ2 H2AZ1	3.03e-05	6	50	2	30842416
Pubmed	Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.	H2AZ2 H2AZ1	4.23e-05	7	50	2	34590699
Pubmed	Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation.	ZEB1 H2AZ2	5.64e-05	8	50	2	24433583
Pubmed	Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers.	H2AZ2 H2AZ1	9.05e-05	10	50	2	25731851
Pubmed	Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development†.	H2AZ2 H2AZ1	1.10e-04	11	50	2	39194072
Pubmed	A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.	H2AZ2 H2AZ1	1.10e-04	11	50	2	25362550
Pubmed	Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder.	H2AZ2 H2AZ1	1.32e-04	12	50	2	29294103
Pubmed	Identification and Characterization of USP7 Targets in Cancer Cells.	TRIP12 NSRP1	1.56e-04	13	50	2	30367141
Pubmed	Precise characterization of human histones in the H2A gene family by top down mass spectrometry.	H2AZ2 H2AZ1	1.82e-04	14	50	2	16457589
Pubmed	Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.	ZEB1 H2AZ2	2.40e-04	16	50	2	25942625
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF569 ZNF778	3.79e-04	20	50	2	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF569 ZNF778	3.79e-04	20	50	2	7479878
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF266 ZNF267	4.18e-04	21	50	2	7865130
Pubmed	A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.	H2AZ2 NRG3	5.03e-04	23	50	2	29532549
Pubmed	Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2.	H2AZ2 H2AZ1	6.95e-04	27	50	2	24311584
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	ZEB1 H2AZ2	9.17e-04	31	50	2	32546759
Pubmed	Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain.	H2AZ2 H2AZ1	9.17e-04	31	50	2	31712428
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 ZEB1 ZNF48 ZNF569 ZKSCAN3 ZNF790	1.03e-03	808	50	6	20412781
Pubmed	Transcription through the nucleosome.	H2AZ2 H2AZ1	1.04e-03	33	50	2	31790919
Cytoband	19p13.2	ZNF823 ZNF266 ZNF846 ZNF558 ZNF799	5.22e-06	229	50	5	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF823 ZNF266 ZNF846 ZNF558 CRTC1 ZNF799 ZNF57	2.42e-05	797	50	7	chr19p13
Cytoband	16p11.2	ZNF771 ZNF48 ZNF267	1.20e-03	191	50	3	16p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF569 ODAD1 ZNF790 ZNF470 ZNF784 ZNF181	1.81e-03	1192	50	6	chr19q13
Cytoband	19q13.12	ZNF569 ZNF790	2.83e-03	72	50	2	19q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	ZNF771 ZNF48 ZNF267	3.49e-03	278	50	3	chr16p11
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 ZNF462 ZNF771 ZNF672 ZEB1 ZNF48 ZNF266 ZNF337 ZNF569 ZNF846 ZKSCAN3 ZNF790 ZNF558 ZNF267 ZNF778 ZNF799 ZNF470 ZNF57 ZNF784 ZNF730 ZNF181 ZFP62	5.86e-22	718	37	22	28
Drug	Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Up 200; 5.8uM; PC3; HT_HG-U133A	TMPRSS15 SECISBP2 CRTC1 ARHGEF4 GLB1L2 AXIN1	3.87e-06	196	49	6	4508_UP
Disease	mitogen-activated protein kinase 3 measurement	ZNF771 ZNF48	2.27e-05	5	45	2	EFO_0020579
Disease	metastatic colorectal cancer, survival time	KCNS3 AXIN1	6.33e-05	8	45	2	EFO_0000714, EFO_1001480
Disease	cumulative dose response to bevacizumab	CRTC1 KCNS3	3.83e-04	19	45	2	EFO_0005944
Disease	keratoconus	PNPLA2 CRTC1	4.58e-03	66	45	2	MONDO_0015486
Disease	schizophrenia (implicated_via_orthology)	NRG3 RIMS2	4.86e-03	68	45	2	DOID:5419 (implicated_via_orthology)
Disease	Endometrial Carcinoma	ZEB1 AXIN1	5.43e-03	72	45	2	C0476089
Disease	Autism Spectrum Disorders	DDHD1 TRIP12	7.49e-03	85	45	2	C1510586
Disease	Uterine leiomyoma	ZEB1 GREB1	8.54e-03	91	45	2	HP_0000131
Disease	Colorectal Neoplasms	ZNF569 ABCA12 ZKSCAN3	8.68e-03	277	45	3	C0009404
Disease	Ischemic stroke, coronary artery disease	USP36 KCNS3	8.73e-03	92	45	2	EFO_0001645, HP_0002140

Protein segments in the cluster

Peptide	Gene	Start	Entry
GTHRGKEASTAALRS	MAMDC4	116	Q6UXC1
GSACSSVKVRSHVGH	AGPAT4-IT1	91	Q9H0P7
IRNKTGSLGHVDSHS	ABCA12	2316	Q86UK0
HLKTRTTSHGRVGAT	H2AZ2	36	Q71UI9
HRGATGDSHLLCTRK	ARHGEF4	576	Q9NR80
IVTDLSGHRKHSSTG	RC3H2	971	Q9HBD1
RGHSTRHHTKGSRTS	NSRP1	296	Q9H0G5
DRGSQSVKHHRSLSS	NRG3	461	P56975
SHEHASGRLGISLTR	PNPLA2	106	Q96AD5
VGGHRSFHITSKVSD	GREB1	1771	Q4ZG55
MGSKRGISSRHHSLS	TMPRSS15	1	P98073
HSVGLRSLGATLRHS	KCNS3	306	Q9BQ31
LSHKTSRDRGSLGHV	ODAD1	546	Q96M63
LRIHSASGRHKAFST	OR9G4	241	Q8NGQ1
RSHGLTRQHSIKNGS	RIMS2	236	Q9UQ26
KTSARRGTLSTTGHS	DNAH3	4071	Q8TD57
SSGLDTSRTTRHHGL	CRTC1	86	Q6UUV9
KEISRHRRTGHGSSG	AXIN1	641	O15169
SGVHGSTLHRNILSS	MAPKBP1	431	O60336
HLKSRTTSHGRVGAT	H2AZ1	36	P0C0S5
SITSSGILSGHVHDR	GLB1L2	436	Q8IW92
LGFSKASSSGTRLHR	DDHD1	376	Q8NEL9
HSHARGSSRAIFSVG	LILRA3	171	Q8N6C8
GTISSEIKSARGSHH	SECISBP2	166	Q96T21
SLAGSLRRHEATHTG	ZNF823	426	P16415
ADSSARVKHLRTHSG	ZNF48	341	Q96MX3
FTGRSGLTKHMRTHT	ZNF778	486	Q96MU6
TRSSGLVLHMRTHTG	ZNF846	376	Q147U1
GLSTHLRTHTGEKAC	ZNF846	436	Q147U1
SQKSALTKHGRTHTG	ZNF771	101	Q7L3S4
SDSSGLTVHRRTHTG	ZNF267	586	Q14586
RSSLTGHNSIHTGEK	ZNF558	276	Q96NG5
SDRSDLTKHRRTHTG	ZNF672	321	Q499Z4
RISSSLRRHETTHTG	ZNF799	431	Q96GE5
GKAFSHGSSLTVHQR	ZNF470	431	Q6ECI4
HLQSHIGSSSRGTRV	SORBS3	21	O60504
RSSTLNRHKITHTGG	ZNF730	351	Q6ZMV8
SHKSGRDQRHVTQSG	ZEB1	221	P37275
SQSSSLTIHIRGHTG	ZNF569	616	Q5MCW4
SLRSSLTGHKRIHTG	ZNF790	236	Q6PG37
SSGLSKHRRIHTGEK	ZKSCAN3	326	Q9BRR0
SNSSGLRVHKRIHTG	ZFP62	291	Q8NB50
HTRKVHGAQAEGSSS	ZNF462	126	Q96JM2
TSSRSFQGHLRTHTG	ZNF57	346	Q68EA5
HSRNKRLSISSGFSG	TMEM217	176	Q8N7C4
SKAHTRKSGATGGSR	TRIP12	131	Q14669
VGCVTDGHHASSRKR	USP36	901	Q9P275
GKTFSHGSSLTRHLI	ZNF181	271	Q2M3W8
SVKGSLLRHQRTHSG	ZNF337	386	Q9Y3M9
SSVLSGHARIHTGER	ZNF784	236	Q8NCA9
RSSRLSEHTRTHTGE	ZNF266	391	Q14584