Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.84e-08261366GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.41e-06521366GO:0005272
GeneOntologyMolecularFunctiondinucleotide repeat insertion binding

MSH2 MSH3

4.60e-0521362GO:0032181
GeneOntologyMolecularFunctionATP-dependent activity

MRE11 SPAST VPS4A MYO1H VPS4B CHD8 MSH2 MSH3 IFIH1 MDN1 ABCA5 STARD9 NAV1 TOP2B

7.88e-0561413614GO:0140657
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN8A

1.06e-04141363GO:0031402
GeneOntologyMolecularFunctionsingle guanine insertion binding

MSH2 MSH3

1.38e-0431362GO:0032142
GeneOntologyMolecularFunctiondinucleotide insertion or deletion binding

MSH2 MSH3

1.38e-0431362GO:0032139
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A SCN10A

1.96e-04171363GO:0099508
GeneOntologyMolecularFunctionguanine/thymine mispair binding

MSH2 MSH3

2.74e-0441362GO:0032137
GeneOntologyMolecularFunctionsingle base insertion or deletion binding

MSH2 MSH3

2.74e-0441362GO:0032138
GeneOntologyMolecularFunctionDNA insertion or deletion binding

MSH2 MSH3

6.78e-0461362GO:0032135
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN8A

7.16e-04261363GO:0031420
GeneOntologyMolecularFunctioncell adhesion molecule binding

MRE11 APC IST1 LAMB1 NLGN1 SVEP1 LGALS8 FASN PTPRZ1 NLGN2 SNX9 PHLDB2

8.22e-0459913612GO:0050839
GeneOntologyMolecularFunctioncentromeric DNA binding

MSH2 MSH3

9.46e-0471362GO:0019237
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.13e-031711366GO:0015081
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.22e-07361366GO:0086010
GeneOntologyBiologicalProcesscell cycle checkpoint signaling

RNASEH2B MRE11 VPS4A GTSE1 APC MSH2 STIL WDR76 MAD1L1 PRKDC

1.81e-0621713610GO:0000075
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

RIPOR2 SPAST APC IST1 LAMB1 SPG11 NLGN1 ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 MAP3K13 TOP2B

2.13e-0674813618GO:0048667
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

3.67e-06631366GO:0019228
GeneOntologyBiologicalProcessneuron projection morphogenesis

SPAST DVL3 APC IST1 LAMB1 SPG11 NLGN1 ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 MAP3K13 TOP2B

5.61e-0680213618GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

SPAST DVL3 APC IST1 LAMB1 SPG11 NLGN1 ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 MAP3K13 TOP2B

7.48e-0681913618GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

SPAST DVL3 APC IST1 LAMB1 SPG11 NLGN1 ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 MAP3K13 TOP2B

8.40e-0682613618GO:0048858
GeneOntologyBiologicalProcessmitotic cell cycle checkpoint signaling

MRE11 VPS4A GTSE1 APC MSH2 STIL MAD1L1 PRKDC

1.28e-051631368GO:0007093
GeneOntologyBiologicalProcesscell cycle process

RNASEH2B MRE11 CCDC8 RIPOR2 SPAST VPS4A VPS4B MEIKIN GTSE1 APC IST1 MSH2 STIL WDR76 C2CD3 TRAPPC12 DBF4 STARD9 MAD1L1 SYCP1 CEP152 PRKDC SNX9 TOP2B

2.26e-05144113624GO:0022402
GeneOntologyBiologicalProcessESCRT III complex disassembly

VPS4A VPS4B IST1

3.25e-05101363GO:1904903
GeneOntologyBiologicalProcessESCRT complex disassembly

VPS4A VPS4B IST1

3.25e-05101363GO:1904896
GeneOntologyBiologicalProcessneuron projection development

RIPOR2 SPAST ENPP1 DVL3 APC IST1 LAMB1 SPG11 NLGN1 ZNF804A ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 NLGN2 MAP3K13 TOP2B

3.45e-05128513622GO:0031175
GeneOntologyBiologicalProcesscell morphogenesis

RIPOR2 SPAST ENPP1 DVL3 APC IST1 LAMB1 SPG11 NLGN1 ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 PRKDC MAP3K13 TOP2B

3.60e-05119413621GO:0000902
GeneOntologyBiologicalProcessnegative regulation of cell cycle phase transition

RNASEH2B MRE11 VPS4A GTSE1 APC MSH2 STIL WDR76 MAD1L1 PRKDC

4.19e-0531113610GO:1901988
GeneOntologyBiologicalProcesslate endosome to lysosome transport via multivesicular body sorting pathway

VPS4A VPS4B

4.32e-0521362GO:0061764
GeneOntologyBiologicalProcesschromosome organization

MRE11 RIPOR2 VPS4A VPS4B MEIKIN APC CHD8 MSH2 MSH3 PARP4 TRAPPC12 MAD1L1 SYCP1 PRKDC TOP2B

4.82e-0568613615GO:0051276
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN4A SCN8A SCN10A

5.54e-05621365GO:0086002
GeneOntologyBiologicalProcessorganelle assembly

RIPOR2 VPS4A VPS4B IST1 SPG11 NLGN1 STIL FBXW8 C2CD3 MDN1 CELSR2 TRAPPC12 BBS7 STARD9 MTMR3 AGFG1 CEP152 NLGN2 PRKDC FOXJ1

5.70e-05113813620GO:0070925
GeneOntologyBiologicalProcesschromosome segregation

MRE11 RIPOR2 VPS4A VPS4B MEIKIN APC STIL TRAPPC12 STARD9 MAD1L1 SYCP1 TOP2B

6.08e-0546513612GO:0007059
GeneOntologyBiologicalProcessmembrane assembly

SPAST VPS4A VPS4B NLGN1 NLGN2

6.46e-05641365GO:0071709
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

9.93e-051121366GO:0019226
GeneOntologyBiologicalProcessmembrane biogenesis

SPAST VPS4A VPS4B NLGN1 NLGN2

1.21e-04731365GO:0044091
GeneOntologyBiologicalProcessnuclear chromosome segregation

MRE11 RIPOR2 VPS4A VPS4B MEIKIN APC TRAPPC12 MAD1L1 SYCP1 TOP2B

1.28e-0435613610GO:0098813
GeneOntologyBiologicalProcesslate endosomal microautophagy

VPS4A VPS4B

1.29e-0431362GO:0061738
GeneOntologyBiologicalProcessheart development

SOX4 ENPP1 DVL3 APC STIL IRX4 PTK7 NEDD4 TGFBR3 C2CD3 NFATC4 BBS7 ROBO1 PRKDC FOXJ1

1.44e-0475713615GO:0007507
GeneOntologyBiologicalProcessnegative regulation of cell cycle process

RNASEH2B MRE11 VPS4A GTSE1 APC MSH2 STIL WDR76 MAD1L1 PRKDC

1.47e-0436213610GO:0010948
GeneOntologyBiologicalProcessmembrane depolarization

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.52e-041211366GO:0051899
GeneOntologyBiologicalProcessregulation of cell cycle phase transition

RNASEH2B MRE11 VPS4A VPS4B GTSE1 APC MSH2 STIL WDR76 DBF4 MAD1L1 PRKDC

1.62e-0451613612GO:1901987
GeneOntologyBiologicalProcessDNA damage response

SOX4 RNASEH2B MRE11 EXO5 GTSE1 APC MSH2 MSH3 SSRP1 WDR76 NEDD4 PARP4 NFATC4 SYCP1 PRKDC USP1 TOP2B

1.95e-0495913617GO:0006974
GeneOntologyBiologicalProcesscytoskeleton-dependent cytokinesis

SPAST VPS4A VPS4B APC IST1 SNX9

1.98e-041271366GO:0061640
GeneOntologyBiologicalProcessneuron development

RIPOR2 SPAST ENPP1 DVL3 APC IST1 LAMB1 SPG11 NLGN1 ZNF804A ATL1 PTK7 NEDD4 FBXW8 CELSR2 NFATC4 LMX1A PTPRZ1 ROBO1 NLGN2 MAP3K13 TOP2B

2.28e-04146313622GO:0048666
GeneOntologyBiologicalProcessvesicle localization

VPS4A VPS4B SPG11 NLGN1 TRAPPC12 BBS7 SYN2 NLGN2

2.38e-042471368GO:0051648
GeneOntologyBiologicalProcesscentriole replication

VPS4B STIL C2CD3 CEP152

2.59e-04471364GO:0007099
GeneOntologyBiologicalProcessnegative regulation of cell cycle

RNASEH2B MRE11 VPS4A GTSE1 APC MSH2 STIL ZNRF4 WDR76 MAD1L1 PRKDC

2.59e-0446413611GO:0045786
GeneOntologyBiologicalProcesscell cycle phase transition

RNASEH2B MRE11 SPAST VPS4A VPS4B GTSE1 APC MSH2 STIL WDR76 DBF4 MAD1L1 PRKDC

2.64e-0462713613GO:0044770
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN4A SCN8A SCN10A

2.77e-04871365GO:0086001
GeneOntologyBiologicalProcesscytokinetic process

SPAST VPS4A VPS4B SNX9

2.81e-04481364GO:0032506
GeneOntologyBiologicalProcessheart morphogenesis

SOX4 DVL3 APC STIL NEDD4 TGFBR3 C2CD3 BBS7 ROBO1

2.84e-043211369GO:0003007
GeneOntologyBiologicalProcessDNA damage checkpoint signaling

RNASEH2B MRE11 GTSE1 MSH2 WDR76 PRKDC

2.87e-041361366GO:0000077
GeneOntologyBiologicalProcesscentral nervous system development

SOX4 ENPP1 VPS4B DVL3 LAMB1 CHD8 SPG11 STIL C2CD3 CELSR2 MTF1 LMX1A PTPRZ1 BBS7 SCN2A ROBO1 PRKDC TOP2B FOXJ1

3.28e-04119713619GO:0007417
GeneOntologyBiologicalProcessaxon development

SPAST ENPP1 APC IST1 LAMB1 SPG11 ATL1 PTK7 LMX1A PTPRZ1 ROBO1 MAP3K13 TOP2B

3.32e-0464213613GO:0061564
GeneOntologyBiologicalProcessregulation of mitotic cell cycle phase transition

RNASEH2B MRE11 VPS4A VPS4B GTSE1 APC STIL DBF4 MAD1L1 PRKDC

3.40e-0440213610GO:1901990
GeneOntologyBiologicalProcessdendrite morphogenesis

NLGN1 NEDD4 FBXW8 CELSR2 NFATC4 PTPRZ1 ROBO1

3.47e-041981367GO:0048813
GeneOntologyBiologicalProcesssignal transduction in response to DNA damage

SOX4 RNASEH2B MRE11 GTSE1 MSH2 WDR76 PRKDC

3.69e-042001367GO:0042770
GeneOntologyBiologicalProcessaxonogenesis

SPAST APC IST1 LAMB1 SPG11 ATL1 PTK7 LMX1A PTPRZ1 ROBO1 MAP3K13 TOP2B

3.75e-0456613612GO:0007409
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN4A SCN8A SCN10A

3.78e-04931365GO:0086003
GeneOntologyBiologicalProcesssynaptic vesicle clustering

NLGN1 SYN2 NLGN2

3.94e-04221363GO:0097091
GeneOntologyBiologicalProcessDNA integrity checkpoint signaling

RNASEH2B MRE11 GTSE1 MSH2 WDR76 PRKDC

4.04e-041451366GO:0031570
GeneOntologyBiologicalProcesscentriole assembly

VPS4B STIL C2CD3 CEP152

4.12e-04531364GO:0098534
GeneOntologyBiologicalProcessmitotic cytokinesis

SPAST VPS4A VPS4B APC SNX9

4.17e-04951365GO:0000281
GeneOntologyBiologicalProcessubiquitin-independent protein catabolic process via the multivesicular body sorting pathway

VPS4A VPS4B

4.26e-0451362GO:0090611
GeneOntologyBiologicalProcesspositive regulation of cell projection organization

RIPOR2 DVL3 APC IST1 NLGN1 ZNF804A PTK7 FBXW8 PTPRZ1 ROBO1 MAP3K13

4.40e-0449413611GO:0031346
GeneOntologyBiologicalProcessdetermination of adult lifespan

ENPP1 MSH2 SCN1A SCN2A

4.43e-04541364GO:0008340
GeneOntologyBiologicalProcessregulation of cell cycle process

RNASEH2B MRE11 CCDC8 RIPOR2 SPAST VPS4A VPS4B GTSE1 APC MSH2 STIL WDR76 DBF4 MAD1L1 PRKDC

4.66e-0484513615GO:0010564
GeneOntologyBiologicalProcesssodium ion transmembrane transport

NEDD4 SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

4.67e-042081367GO:0035725
GeneOntologyBiologicalProcessendomembrane system organization

COG2 SPAST VPS4A VPS4B IST1 POLR2M DCST1 ATL1 FBXW8 OSBPL2 TRAPPC12 AGFG1 SNX9

5.11e-0467213613GO:0010256
GeneOntologyBiologicalProcessmitotic cell cycle process

RNASEH2B MRE11 CCDC8 RIPOR2 SPAST VPS4A VPS4B GTSE1 APC MSH2 STIL DBF4 MAD1L1 PRKDC SNX9

5.20e-0485413615GO:1903047
GeneOntologyBiologicalProcessactin filament-based movement

MYO1H SCN1A SCN2A SCN4A SCN8A SCN10A

5.37e-041531366GO:0030048
GeneOntologyBiologicalProcessembryonic organ morphogenesis

RIPOR2 ENPP1 DVL3 STIL PTK7 HOXB5 C2CD3 BBS7 PHACTR4

5.44e-043511369GO:0048562
GeneOntologyBiologicalProcessmitotic cell cycle phase transition

RNASEH2B MRE11 SPAST VPS4A VPS4B GTSE1 APC STIL DBF4 MAD1L1 PRKDC

5.64e-0450913611GO:0044772
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle

MRE11 VPS4A GTSE1 APC MSH2 STIL MAD1L1 PRKDC

5.75e-042821368GO:0045930
GeneOntologyBiologicalProcessregulation of mitotic cell cycle

RNASEH2B MRE11 CCDC8 VPS4A VPS4B GTSE1 APC MSH2 STIL DBF4 MAD1L1 PRKDC

5.76e-0459413612GO:0007346
GeneOntologyBiologicalProcessnuclear division

MRE11 CCDC8 RIPOR2 SPAST VPS4A VPS4B MEIKIN APC MAD1L1 SYCP1 TOP2B

5.92e-0451213611GO:0000280
GeneOntologyBiologicalProcessregulation of dendrite morphogenesis

NEDD4 FBXW8 NFATC4 PTPRZ1 ROBO1

6.04e-041031365GO:0048814
GeneOntologyBiologicalProcessabscission

VPS4A IST1

6.36e-0461362GO:0009838
GeneOntologyBiologicalProcesspositive regulation of helicase activity

MSH2 MSH3

6.36e-0461362GO:0051096
GeneOntologyBiologicalProcessviral budding

VPS4A VPS4B NEDD4

6.52e-04261363GO:0046755
GeneOntologyBiologicalProcessnuclear membrane reassembly

SPAST VPS4A VPS4B

6.52e-04261363GO:0031468
GeneOntologyBiologicalProcesswalking behavior

ENPP1 SPG11 SCN1A SCN8A

6.62e-04601364GO:0090659
GeneOntologyBiologicalProcessanimal organ morphogenesis

SOX4 RIPOR2 ENPP1 DVL3 APC LAMB1 STIL AHDC1 IRX4 PTK7 NEDD4 TGFBR3 HOXB5 PPARGC1B C2CD3 BBS7 PHACTR4 SCN10A ROBO1

6.71e-04126913619GO:0009887
GeneOntologyBiologicalProcessmetaphase chromosome alignment

VPS4A VPS4B APC TRAPPC12 MAD1L1

7.18e-041071365GO:0051310
GeneOntologyBiologicalProcessregulation of respiratory gaseous exchange

NLGN1 NLGN2 NMBR

7.30e-04271363GO:0043576
GeneOntologyBiologicalProcessmitotic recombination

MRE11 MSH2 MSH3

7.30e-04271363GO:0006312
GeneOntologyBiologicalProcesspattern specification process

APC STIL IRX4 HOXB5 C2CD3 CELSR2 BBS7 ROBO1 PRKDC CRAMP1 FOXJ1

7.39e-0452613611GO:0007389
GeneOntologyBiologicalProcessorganelle localization

SPAST VPS4A VPS4B APC POLR2M SPG11 NLGN1 MDN1 TRAPPC12 BBS7 MAD1L1 SYN2 NLGN2

7.76e-0470313613GO:0051640
GeneOntologyBiologicalProcessmaintenance of DNA repeat elements

MSH2 MSH3

8.87e-0471362GO:0043570
GeneOntologyBiologicalProcessnucleus organization

SPAST VPS4A VPS4B BAZ2A SYCP1 AGFG1

9.33e-041701366GO:0006997
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

CCDC8 RIPOR2 SPAST VPS4B APC STIL TUBA8 C2CD3 STARD9 NAV1 CEP152 PHLDB2 FOXJ1

9.65e-0472013613GO:0000226
GeneOntologyBiologicalProcessviral release from host cell

VPS4A VPS4B IST1

9.99e-04301363GO:0019076
GeneOntologyBiologicalProcessexit from host cell

VPS4A VPS4B IST1

9.99e-04301363GO:0035891
GeneOntologyBiologicalProcessadult locomotory behavior

ENPP1 SCN1A SCN8A NLGN2 TRMT1L

1.03e-031161365GO:0008344
GeneOntologyBiologicalProcessmitotic cell cycle

RNASEH2B MRE11 CCDC8 RIPOR2 SPAST VPS4A VPS4B GTSE1 APC MSH2 STIL TUBA8 DBF4 MAD1L1 PRKDC SNX9

1.06e-03101413616GO:0000278
GeneOntologyBiologicalProcessregulation of microtubule cytoskeleton organization

RIPOR2 SPAST VPS4B APC STIL PHLDB2

1.12e-031761366GO:0070507
GeneOntologyBiologicalProcesspositive regulation of protein localization to synapse

NLGN1 NLGN2

1.18e-0381362GO:1902474
GeneOntologyBiologicalProcesscentriole elongation

VPS4B C2CD3

1.18e-0381362GO:0061511
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle clustering

NLGN1 NLGN2

1.18e-0381362GO:2000809
GeneOntologyBiologicalProcesspositive regulation of neuron projection arborization

DVL3 MAP3K13

1.18e-0381362GO:0150012
GeneOntologyBiologicalProcessregulation of double-strand break repair via nonhomologous end joining

MRE11 PRKDC TOP2B

1.21e-03321363GO:2001032
GeneOntologyBiologicalProcesstrabecula formation

ENPP1 TGFBR3 PPARGC1B

1.21e-03321363GO:0060343
GeneOntologyBiologicalProcesssynaptic vesicle localization

SPG11 NLGN1 SYN2 NLGN2

1.25e-03711364GO:0097479
GeneOntologyBiologicalProcessestablishment of chromosome localization

VPS4A VPS4B APC TRAPPC12 MAD1L1

1.29e-031221365GO:0051303
GeneOntologyBiologicalProcessprotein targeting to lysosome

ZFYVE16 VPS4A NEDD4

1.32e-03331363GO:0006622
GeneOntologyBiologicalProcessmultivesicular body assembly

VPS4A VPS4B IST1

1.32e-03331363GO:0036258
GeneOntologyBiologicalProcesstissue morphogenesis

ENPP1 DVL3 APC STIL AHDC1 PTK7 TGFBR3 C2CD3 NFATC4 BBS7 PHACTR4 ROBO1 PHLDB2

1.39e-0375013613GO:0048729
GeneOntologyBiologicalProcessorganelle fission

MRE11 CCDC8 RIPOR2 SPAST VPS4A VPS4B MEIKIN APC MAD1L1 SYCP1 TOP2B

1.43e-0357113611GO:0048285
GeneOntologyBiologicalProcessmultivesicular body organization

VPS4A VPS4B IST1

1.44e-03341363GO:0036257
GeneOntologyBiologicalProcessregulation of spindle assembly

RIPOR2 VPS4B STIL

1.44e-03341363GO:0090169
GeneOntologyBiologicalProcessterminal button organization

NLGN1 NLGN2

1.51e-0391362GO:0072553
GeneOntologyBiologicalProcesspositive regulation of centriole replication

VPS4B STIL

1.51e-0391362GO:0046601
GeneOntologyBiologicalProcesspositive regulation of vascular endothelial growth factor signaling pathway

ADAMTS3 ROBO1

1.51e-0391362GO:1900748
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

9.44e-10171406GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

3.39e-08291406GO:0034706
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN2A SCN8A NAV1

4.02e-05291404GO:0043194
GeneOntologyCellularComponentMutSbeta complex

MSH2 MSH3

4.45e-0521402GO:0032302
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN2A SCN8A

3.08e-04201403GO:0033268
GeneOntologyCellularComponentaxon

SPAST AZIN2 APC SPG11 ZNF804A ATL1 PTK7 PTPRZ1 SCN1A SCN2A SCN4A SCN8A SCN10A NAV1 ROBO1 NLGN2

3.16e-0489114016GO:0030424
GeneOntologyCellularComponentmain axon

SCN1A SCN2A SCN8A NAV1 ROBO1

3.32e-04891405GO:0044304
GeneOntologyCellularComponent3M complex

CCDC8 FBXW8

4.40e-0451402GO:1990393
GeneOntologyCellularComponentprocentriole replication complex

STIL CEP152

6.56e-0461402GO:0120099
GeneOntologyCellularComponentmidbody

ARL2BP SPAST VPS4A NEXMIF VPS4B IST1 DEFA6

7.55e-042221407GO:0030496
GeneOntologyCellularComponentchromatin

SOX4 MRE11 ZBTB22 DVL3 IST1 CHD8 HSFY1 SSRP1 WDR76 ATF6B IRX4 NEDD4 HOXB5 ZBED4 BAZ2A NFATC4 LMX1A MKX PRKDC TOP2B FOXJ1

8.56e-04148014021GO:0000785
HumanPhenoGeneralized myoclonic-atonic seizure

NEXMIF SCN1A CAMTA1 MED13

3.27e-0611534HP:0011170
HumanPhenoSimplified gyral pattern

SOX4 STIL AHDC1 C2CD3 TRAPPC12 CEP152 PRKDC

2.15e-0584537HP:0009879
HumanPhenoAbnormal cortical gyration

SOX4 ADAMTS3 VPS4A LAMB1 STIL TUBA8 AHDC1 C2CD3 TRAPPC12 SCN2A ROBO1 CEP152 PRKDC CAMTA1

2.69e-053885314HP:0002536
MousePhenoincreased osteosarcoma incidence

APC MSH2 PTPRZ1 MAD1L1

3.60e-06131214MP:0003789
MousePhenoincreased skeletal tumor incidence

APC MSH2 PTPRZ1 MAD1L1

8.97e-06161214MP:0010280
MousePhenoabnormal social investigation

NEXMIF CHD8 NLGN1 MIGA2 SCN1A SCN2A SYN2 NCOA7 NLGN2

1.74e-051711219MP:0001360
MousePhenoabnormal response to social novelty

NEXMIF MIGA2 SCN1A SCN2A NCOA7

6.29e-05491215MP:0020395
DomainNa_channel_asu

SCN1A SCN2A SCN4A SCN8A SCN10A

4.83e-09101375IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN4A SCN8A SCN10A

4.83e-09101375IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN4A SCN8A SCN10A

4.83e-09101375PF06512
DomainChannel_four-helix_dom

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

3.72e-06571376IPR027359
Domain-

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

3.72e-065713761.20.120.350
DomainNa_trans_cytopl

SCN1A SCN2A SCN8A

7.60e-0661373PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN8A

7.60e-0661373IPR024583
DomainVps4_C

SPAST VPS4A VPS4B

2.10e-0581373IPR015415
DomainVps4_C

SPAST VPS4A VPS4B

2.10e-0581373PF09336
DomainMIT

SPAST VPS4A VPS4B

4.46e-05101373SM00745
DomainMIT

SPAST VPS4A VPS4B

4.46e-05101373PF04212
DomainIQ_motif_EF-hand-BS

SCN1A SCN2A SCN4A SCN8A SCN10A CAMTA1

5.24e-05901376IPR000048
DomainMiga

MIGA2 MIGA1

5.34e-0521372IPR019392
DomainMiga

MIGA2 MIGA1

5.34e-0521372PF10265
DomainIQ

SCN1A SCN2A SCN4A SCN8A SCN10A CAMTA1

6.30e-05931376PS50096
DomainMIT

SPAST VPS4A VPS4B

1.32e-04141373IPR007330
DomainDUF4683

NEXMIF AHDC1

1.59e-0431372PF15735
Domain-

MSH2 MSH3

1.59e-04313723.30.420.110
DomainDNA_mismatch_repair_MutS-lik_N

MSH2 MSH3

1.59e-0431372IPR007695
DomainMutS_I

MSH2 MSH3

1.59e-0431372PF01624
DomainDUF4683

NEXMIF AHDC1

1.59e-0431372IPR032757
DomainIQ

SCN1A SCN4A SCN8A SCN10A CAMTA1

1.74e-04711375PF00612
DomainIon_trans_dom

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.95e-041141376IPR005821
DomainIon_trans

SCN1A SCN2A SCN4A SCN8A SCN10A CACNA1I

1.95e-041141376PF00520
DomainDNA_mmatch_repair_MutS_con_dom

MSH2 MSH3

3.17e-0441372IPR007860
DomainMutS_II

MSH2 MSH3

3.17e-0441372PF05188
DomainIQ

SCN1A SCN2A SCN4A SCN8A CAMTA1

3.23e-04811375SM00015
DomainMUTSd

MSH2 MSH3

5.26e-0451372SM00533
DomainMUTSac

MSH2 MSH3

5.26e-0451372SM00534
DomainMutS_V

MSH2 MSH3

5.26e-0451372PF00488
DomainDNA_mismatch_repair_MutS_clamp

MSH2 MSH3

5.26e-0451372IPR007861
DomainDNA_MISMATCH_REPAIR_2

MSH2 MSH3

5.26e-0451372PS00486
DomainNlgn

NLGN1 NLGN2

5.26e-0451372IPR000460
DomainMutS_IV

MSH2 MSH3

5.26e-0451372PF05190
DomainMutS_III

MSH2 MSH3

5.26e-0451372PF05192
DomainDNA_mismatch_repair_MutS_C

MSH2 MSH3

5.26e-0451372IPR000432
DomainDNA_mismatch_repair_MutS_core

MSH2 MSH3

5.26e-0451372IPR007696
DomainAAA

SPAST VPS4A VPS4B MDN1 ABCA5 NAV1

6.80e-041441376SM00382
DomainAAA+_ATPase

SPAST VPS4A VPS4B MDN1 ABCA5 NAV1

6.80e-041441376IPR003593
DomainZnf_FYVE_PHD

INTS12 PHF19 ZFYVE16 BAZ2A PHF3 MTMR3

7.57e-041471376IPR011011
DomainATPase_AAA_CS

SPAST VPS4A VPS4B

1.23e-03291373IPR003960
DomainAAA

SPAST VPS4A VPS4B

1.96e-03341373PS00674
DomainPHD

INTS12 PHF19 BAZ2A PHF3

2.25e-03751374PF00628
DomainZnf_PHD-finger

INTS12 PHF19 BAZ2A PHF3

2.72e-03791374IPR019787
DomainGFP-like

SVEP1 SUSD1

2.81e-03111372IPR023413
Domain-

SVEP1 SUSD1

2.81e-031113722.40.155.10
DomainP-loop_NTPase

SPAST VPS4A VPS4B CHD8 MSH2 MSH3 ATL1 IFIH1 MDN1 ABCA5 STARD9 NAV1 CAMTA1 NLRP13

3.81e-0384813714IPR027417
Domain-

VPS4A VPS4B

3.95e-031313721.20.58.280
DomainCarboxylesterase_B_CS

NLGN1 NLGN2

3.95e-03131372IPR019819
DomainPHD

INTS12 PHF19 BAZ2A PHF3

4.18e-03891374SM00249
DomainZnf_PHD

INTS12 PHF19 BAZ2A PHF3

4.52e-03911374IPR001965
DomainCARBOXYLESTERASE_B_2

NLGN1 NLGN2

4.59e-03141372PS00941
DomainCOesterase

NLGN1 NLGN2

4.59e-03141372PF00135
DomainCarbesteraseB

NLGN1 NLGN2

4.59e-03141372IPR002018
DomainZF_PHD_2

INTS12 PHF19 BAZ2A PHF3

5.27e-03951374PS50016
DomainZF_PHD_1

INTS12 PHF19 BAZ2A PHF3

5.47e-03961374PS01359
DomainAAA

SPAST VPS4A VPS4B

6.56e-03521373PF00004
DomainHomeobox_KN

IRX4 MKX

6.76e-03171372PF05920
DomainHomeobox_KN_domain

IRX4 MKX

6.76e-03171372IPR008422
DomainATPase_AAA_core

SPAST VPS4A VPS4B

7.29e-03541373IPR003959
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN4A SCN8A SCN10A

1.85e-0631955M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN4A SCN8A SCN10A

2.18e-0632955M27455
PathwayREACTOME_L1CAM_INTERACTIONS

LAMB1 TUBA8 SCN1A SCN2A SCN4A SCN8A SCN10A

1.71e-05121957M872
PathwayREACTOME_SEALING_OF_THE_NUCLEAR_ENVELOPE_NE_BY_ESCRT_III

SPAST VPS4A IST1 TUBA8

3.02e-0527954MM15674
PathwayREACTOME_SEALING_OF_THE_NUCLEAR_ENVELOPE_NE_BY_ESCRT_III

SPAST VPS4A IST1 TUBA8

6.02e-0532954M29848
PathwayREACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY

SPAST VPS4A IST1 TUBA8 PPP2R2A

9.32e-0568955MM14921
PathwayREACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY

SPAST VPS4A IST1 TUBA8 PPP2R2A

1.58e-0476955M27215
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SYNRG CCDC8 SPAST INTS12 GTSE1 APC STIL SSRP1 DENND2B NEDD4 C2CD3 MDN1 FAM171A2 PHF3 STARD9 PHACTR4 MAD1L1 AGFG1 NAV1 NCOA7 CEP152 PHLDB2

7.67e-128611422236931259
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN4A SCN8A SCN10A

1.31e-109142516382098
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SOX4 SYNRG GTSE1 SLCO4A1 CHD8 AHDC1 FASN C2CD3 MDN1 CELSR2 ZBED4 TRAPPC12 MAD1L1 SCN8A MTMR3 ZNF398 NAV1 MLLT1 NLGN2 PRKDC CABIN1 CRAMP1 MED13

1.44e-1011051422335748872
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MRE11 SYNRG EXO5 GTSE1 SLCO4A1 SSRP1 FASN MDN1 BAZ2A ZC3H4 PHF3 DBF4 PHACTR4 MAD1L1 RBM6 PRKDC MED13 TOP2B PHLDB2

4.53e-107741421915302935
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

RIPOR2 ADAMTS3 ZFYVE16 NACAD MDN1 BAZ2A MTMR3 IGSF1 CABIN1

4.83e-1010414299205841
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

NEDD4 SCN1A SCN2A SCN8A SCN10A

1.33e-0913142515123669
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN8A SCN10A

3.97e-096142423652591
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

INTS12 RPN2 SPG11 SSRP1 SRBD1 PTK7 FASN C2CD3 MDN1 CLCN5 ZBED4 SUSD1 STARD9 SCN4A SYCP1 MLLT1 PRKDC SNX9 USP1 KIAA2012 MED13 TOP2B ERICH6

2.23e-0814421422335575683
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN4A SCN8A

3.30e-089142415746173
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A SCN8A

6.66e-083142332845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A SCN8A

6.66e-083142328518218
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A SCN8A

6.66e-083142317928448
Pubmed

Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM.

SPAST VPS4A IST1

6.66e-083142330110633
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RIPOR2 ZFYVE16 IST1 NLGN1 NEDD4 ZBED4 BAZ2A PHF3 STARD9 MTMR3 NAV1 CAMTA1

1.24e-074071421212693553
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

MSH2 FASN MDN1 RBM6 MLLT1 PRKDC SNX9 KIAA2012 MED13 TOP2B

1.95e-072721421031010829
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN8A

2.66e-074142317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN8A

2.66e-074142335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN8A

2.66e-074142329578003
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A SCN8A

2.66e-074142321156207
Pubmed

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.

SPAST VPS4A VPS4B IST1

3.51e-0715142426040712
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN4A SCN8A

6.62e-075142317724025
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

GTSE1 ZBTB22 CHD8 FAM131A AHDC1 FASN ZBED4 ZC3H4 NAV1 PRKDC

1.20e-063321421037433992
Pubmed

The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process.

VPS4A VPS4B NEDD4

1.32e-066142320164219
Pubmed

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

SPAST VPS4A IST1

1.32e-066142328242692
Pubmed

Pathology of mouse models of intestinal cancer: consensus report and recommendations.

APC MSH2 MSH3

1.32e-066142312612914
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

RPN2 MSH2 PARP4 FASN ZC3H4 CRYBG1 PRKDC TOP2B

1.94e-06202142833005030
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ZFYVE16 VPS4B APC SLCO4A1 SPG11 ATL1 NFATC4 TRAPPC12 BBS7 PHF3 AGFG1 NAV1 ROBO1 USP1

2.02e-067331421434672954
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A SCN8A

2.30e-067142325818041
Pubmed

Biochemical analyses of human IST1 and its function in cytokinesis.

VPS4A VPS4B IST1

2.30e-067142319129479
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

MRE11 CHD8 SSRP1 BAZ2A ZC3H4 PHF3 PRKDC TRMT1L TOP2B

2.68e-06283142930585729
Pubmed

Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy.

MRE11 PRKDC TOP2B

3.68e-068142328345663
Pubmed

HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα.

MRE11 MSH2 MSH3

3.68e-068142324882211
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

MRE11 ZFYVE16 GTSE1 CHD8 MSH2 SRBD1 PPP2R2A ZC3H4 PHF3 MLLT1 TRMT1L

4.14e-064721421138943005
Pubmed

A census of human transcription factors: function, expression and evolution.

SOX4 HSFY1 ATF6B IRX4 HOXB5 ZBED4 MTF1 NFATC4 LMX1A MKX ZNF398 MLLT1 CAMTA1 CRAMP1 FOXJ1

5.01e-069081421519274049
Pubmed

Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.

MRE11 MSH2 SSRP1 MDN1 PRKDC TOP2B

5.08e-06106142619394292
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

CCDC8 RPN2 DVL3 LAMB1 MSH3 PPP2R2A FASN FBXW8 RBM6 TRMT1L PHLDB2

6.62e-064961421131343991
Pubmed

TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.

MRE11 MSH2 MSH3 PRKDC

7.69e-0631142426095369
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

MRE11 CHD8 MSH2 MSH3 FASN MDN1 PHF3 PRKDC TRMT1L

9.70e-06332142932786267
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ZBTB22 APC CHD8 ATF6B NEDD4 MDN1 CELSR2 FAM171A2 ZC3H4 MAD1L1 NAV1 NLGN2 CABIN1 PHLDB2 SH3BP5

1.01e-059631421528671696
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

MRE11 GTSE1 DVL3 APC FASN ROBO1 PRKDC USP1

1.11e-05256142833397691
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MRE11 INTS12 GTSE1 MSH3 FASN FBXW8 MDN1 NFATC4 MAD1L1 TRMT1L CABIN1 SNX9 TOP2B FOXJ1

1.19e-058571421425609649
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SPAST CHD8 SPG11 NACAD PPP2R2A ABCA5 ZC3H4 IPO13 IGSF1 CRAMP1 MED13

1.21e-055291421114621295
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN8A

1.43e-0512142330175250
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

1.66e-052142237901435
Pubmed

Mutation analysis of four Chinese families with pure hereditary spastic paraplegia: pseudo- X-linked dominant inheritance and male lethality due to a novel ATL1 mutation.

SPAST ATL1

1.66e-052142226600529
Pubmed

Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3.

AGFG1 RBM6

1.66e-05214229500467
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

1.66e-052142226410685
Pubmed

Phosphatidylethanolamine, a limiting factor of autophagy in yeast strains bearing a defect in the carboxypeptidase Y pathway of vacuolar targeting.

VPS4A VPS4B

1.66e-052142217428789
Pubmed

Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops.

MSH2 MSH3

1.66e-052142221960445
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

1.66e-052142210827969
Pubmed

Identification of pauses during formation of HIV-1 virus like particles.

VPS4A VPS4B

1.66e-052142224268138
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

1.66e-052142219694741
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

1.66e-052142235348308
Pubmed

Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking.

VPS4A VPS4B

1.66e-052142210393249
Pubmed

DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.

LMX1A PRKDC

1.66e-052142224194952
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

1.66e-052142215760941
Pubmed

An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome.

SPAST IST1

1.66e-052142223897888
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

1.66e-05214221317301
Pubmed

Influenza virus budding does not require a functional AAA+ ATPase, VPS4.

VPS4A VPS4B

1.66e-052142220621136
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

1.66e-052142231439038
Pubmed

Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor.

APC MSH2

1.66e-052142211507063
Pubmed

Mutational spectrum of the SPAST and ATL1 genes in Korean patients with hereditary spastic paraplegia.

SPAST ATL1

1.66e-052142226208798
Pubmed

Comparative sequence and expression analyses of four mammalian VPS4 genes.

VPS4A VPS4B

1.66e-052142212594041
Pubmed

Copy number variations in SPAST and ATL1 are rare among Brazilians.

SPAST ATL1

1.66e-052142236537231
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

1.66e-052142231943325
Pubmed

Novel SPG3A and SPG4 mutations in two patients with Silver syndrome.

SPAST ATL1

1.66e-052142219730024
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

1.66e-052142215249644
Pubmed

The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.

VPS4A VPS4B

1.66e-05214229211789
Pubmed

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance.

SPAST ATL1

1.66e-052142216815977
Pubmed

Three novel mutations in 20 patients with hereditary spastic paraparesis.

SPAST ATL1

1.66e-052142229907907
Pubmed

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.

APC MSH2

1.66e-052142228522752
Pubmed

Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects.

MSH2 MSH3

1.66e-052142221128252
Pubmed

Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha.

MSH2 MSH3

1.66e-05214229677427
Pubmed

Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.

APC MSH2

1.66e-052142212584170
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

1.66e-052142218601978
Pubmed

Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer.

APC FASN

1.66e-052142235742953
Pubmed

Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking.

VPS4A VPS4B

1.66e-052142211563910
Pubmed

Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.

NLGN1 NLGN2

1.66e-052142219889999
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

1.66e-052142219465131
Pubmed

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

APC MSH2

1.66e-052142219765110
Pubmed

Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.

MSH2 MSH3

1.66e-052142219525234
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

1.66e-052142230693367
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

1.66e-052142223735284
Pubmed

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.

VPS4A VPS4B

1.66e-052142231930723
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

1.66e-052142229649454
Pubmed

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops.

MSH2 MSH3

1.66e-052142222179786
Pubmed

Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.

NLGN1 NLGN2

1.66e-052142210892652
Pubmed

Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation.

APC PRKDC

1.66e-05214228567125
Pubmed

Three-dimensional structure of AAA ATPase Vps4: advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding.

VPS4A VPS4B

1.66e-052142219278657
Pubmed

hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA.

MSH2 MSH3

1.66e-05214228805365
Pubmed

Effective oligonucleotide-mediated gene disruption in ES cells lacking the mismatch repair protein MSH3.

MSH2 MSH3

1.66e-052142216437133
Pubmed

MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.

APC MSH2

1.66e-05214228674041
Pubmed

(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition.

MSH2 MSH3

1.66e-052142216025128
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

1.66e-052142233096315
Pubmed

NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and strengthening.

NLGN1 NLGN2

1.66e-052142229278843
Pubmed

Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice.

APC MSH2

1.66e-052142210866310
Pubmed

Mutational Spectrum of Spast (Spg4) and Atl1 (Spg3a) Genes In Russian Patients With Hereditary Spastic Paraplegia.

SPAST ATL1

1.66e-052142231594988
Pubmed

Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners.

SPAST ATL1

1.66e-052142216339213
Pubmed

Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.

MIGA2 MIGA1

1.66e-052142226716412
Pubmed

Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4.

VPS4A VPS4B

1.66e-052142236042696
InteractionYWHAH interactions

SYNRG CCDC8 SPAST INTS12 GTSE1 APC STIL SSRP1 DENND2B NEDD4 IFIH1 C2CD3 FAM171A2 PHF3 STARD9 PHACTR4 MAD1L1 MTMR3 AGFG1 NAV1 NCOA7 CEP152 PHLDB2

2.39e-06110214123int:YWHAH
InteractionMAU2 interactions

SSRP1 FASN MDN1 MLLT1 PRKDC SNX9 MED13 TOP2B

5.21e-061361418int:MAU2
InteractionUHRF2 interactions

MRE11 INTS12 DVL3 CHD8 MSH3 SSRP1 PHF3 PRKDC TOP2B

1.18e-052001419int:UHRF2
InteractionCHMP1B interactions

SPAST VPS4A VPS4B IST1 SSRP1

1.52e-05451415int:CHMP1B
InteractionMEX3A interactions

GTSE1 ZBTB22 DVL3 CHD8 FAM131A MSH2 AHDC1 FASN ZBED4 ZC3H4 NAV1 PRKDC

1.69e-0538414112int:MEX3A
InteractionSCN4B interactions

SCN1A SCN2A SCN8A

1.83e-0581413int:SCN4B
InteractionTOP3B interactions

SOX4 SYNRG GTSE1 SLCO4A1 CHD8 MSH3 SSRP1 AHDC1 FASN C2CD3 MDN1 CELSR2 ZBED4 TRAPPC12 MAD1L1 SCN8A MTMR3 ZNF398 NAV1 MLLT1 NLGN2 PRKDC CABIN1 CRAMP1 MED13

2.92e-05147014125int:TOP3B
InteractionSCN1A interactions

PTK7 NEDD4 SCN1A SCN10A

4.76e-05291414int:SCN1A
InteractionSCN10A interactions

NEDD4 SCN1A SCN10A

5.31e-05111413int:SCN10A
InteractionYWHAG interactions

SYNRG CCDC8 RIPOR2 SPAST GTSE1 APC DENND2B LGALS8 NEDD4 C2CD3 MDN1 FAM171A2 PHF3 STARD9 PHACTR4 MAD1L1 MTMR3 AGFG1 NAV1 SYN2 PRKDC PHLDB2

5.54e-05124814122int:YWHAG
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN4A SCN8A SCN10A

4.96e-1099751203
GeneFamilyAAA ATPases|ESCRT-IV

VPS4A VPS4B

8.52e-0539721120
GeneFamilyAAA ATPases

SPAST VPS4A VPS4B MDN1

1.86e-0453974413
GeneFamilyMutS homologs|PWWP domain containing

MSH2 MSH3

2.82e-0459721026
GeneFamilyPHD finger proteins

INTS12 PHF19 BAZ2A PHF3

1.40e-039097488
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

SPAST ZFYVE16 APC SPG11 MSH2 MSH3 STIL ZNF804A DENND2B AHDC1 NEDD4 TGFBR3 PPP2R2A C2CD3 MDN1 ZC3H4 PHF3 DBF4 MAD1L1 MTMR3 AGFG1 RBM6 MED13

2.03e-1085614123M4500
CoexpressionGSE21360_PRIMARY_VS_QUATERNARY_MEMORY_CD8_TCELL_DN

ARL2BP RIPOR2 ZFYVE16 ZBTB22 SPG11 C2CD3 OSBPL2 CELSR2 BAZ2A TOP2B

1.26e-0719814110M7610
CoexpressionGSE28737_WT_VS_BCL6_HET_MARGINAL_ZONE_BCELL_UP

SOX4 RIPOR2 CHD8 ZNF804A ARR3 ABCA5 MAD1L1 ZNF398 TOP2B PADI3

1.39e-0720014110M9342
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

RIPOR2 SPAST ADAMTS3 APC NLGN1 AHDC1 ATL1 PPARGC1B MDN1 SCN1A SCN2A SCN8A NAV1 SYN2 NCOA7 ROBO1 CACNA1I CAMTA1 SH3BP5

7.83e-06110614119M39071
CoexpressionBLUM_RESPONSE_TO_SALIRASIB_DN

SOX4 MRE11 APC MSH2 STIL FASN PRKDC DBR1 USP1 TOP2B

1.67e-0534114110M2879
CoexpressionCAIRO_HEPATOBLASTOMA_CLASSES_UP

MRE11 RPN2 GTSE1 SLCO4A1 MSH2 SSRP1 MDN1 OSBPL2 DBF4 MAD1L1 AGFG1 PRKDC IGSF1

2.79e-0561214113M4772
CoexpressionKAUFFMANN_DNA_REPAIR_GENES

MRE11 MSH2 MSH3 SSRP1 PARP4 MAD1L1 PRKDC TOP2B

3.62e-052301418M11563
CoexpressionGSE37301_PRO_BCELL_VS_CD4_TCELL_UP

SOX4 RIPOR2 ATF6B AHDC1 TGFBR3 MLLT1 SH3BP5

3.89e-051701417M8893
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

MSH2 STIL ZNF804A NEDD4 PPP2R2A C2CD3 MDN1 ZC3H4 PHF3 RBM6 MED13

4.61e-0546614111M13522
CoexpressionGENTILE_UV_RESPONSE_CLUSTER_D2

ZBED4 ZC3H4 PHF3 MTMR3

5.14e-05381414M12861
CoexpressionGSE19941_LPS_VS_LPS_AND_IL10_STIM_IL10_KO_MACROPHAGE_UP

SOX4 RPN2 GTSE1 SSRP1 WDR76 AHDC1 PHACTR4

5.99e-051821417M8126
CoexpressionGSE46606_IRF4_KO_VS_WT_CD40L_IL2_IL5_3DAY_STIMULATED_BCELL_UP

SOX4 AZIN2 DENND2B FASN SUSD1 ABCA5 MAP3K13

9.54e-051961417M9821
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

SYNRG SPAST ZFYVE16 MSH3 BAZ2A USP32 MIGA1 PRKDC MED13

1.25e-081931429abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

PHF19 GTSE1 MSH2 STIL SSRP1 WDR76 PRKDC USP1

2.67e-0720014287e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

PHF19 GTSE1 MSH2 STIL SSRP1 WDR76 PRKDC USP1

2.67e-0720014289775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PHF19 GTSE1 STIL DBF4 SCN4A CEP152 PADI3

1.31e-061711427c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCellE18.5-samps-Mesenchymal-Myofibroblast|E18.5-samps / Age Group, Lineage, Cell class and subclass

SOX4 DVL3 NLGN1 TGFBR3 HOXB5 ROBO1 NLGN2

2.06e-061831427de08f9ea02b7244d5a8788064631d10f06565337
ToppCellCOVID-19_Mild-Neu_4|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

RPN2 POLR2M DENND2B SVEP1 PHACTR4 MIGA1 SNX9

2.37e-061871427714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D175|Adult / Lineage, Cell type, age group and donor

ADAMTS3 NLGN1 SVEP1 TGFBR3 LMX1A NAV1 PHLDB2

2.64e-0619014277dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell|Adult / Lineage, Cell type, age group and donor

NLGN1 SVEP1 TGFBR3 NFATC4 LMX1A NAV1 PHLDB2

2.82e-061921427d21f0f577156f17c899b08871046a26b88aea011
ToppCellCOVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Severe / Disease group, lineage and cell class

PHF19 GTSE1 MSH2 STIL SSRP1 WDR76 USP1

3.58e-061991427ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_ventral_progenitors|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

PHF19 GTSE1 STIL WDR76 DBF4 CEP152 USP1

3.58e-061991427446cd7d960812519fe2b8e434578ef0b668c75ce
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMB1 NLGN1 SVEP1 TGFBR3 LMX1A NAV1 PHLDB2

3.70e-062001427ad3fdcef895400f929f2ae12ff9bd85fd46adb3a
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-T/NK_proliferative|COVID-19_Severe / Disease, condition lineage and cell class

PHF19 GTSE1 MSH2 STIL SSRP1 WDR76 USP1

3.70e-0620014270892603e604c2a945dd720685d45970f855bd5d3
ToppCellmild-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF19 GTSE1 MSH2 STIL WDR76 TGFBR3 CEP152

3.70e-06200142763cc57b9331459efbb73051d174d198a3568b938
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

VPS4B ATL1 HOXB5 FBXW8 ROBO1 IGSF1

1.67e-05168142653a982869dbf14f6a948589be9f2f3df3b9a7e97
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

INTS12 ZNF804A TGFBR3 SERPINI2 LMX1A ROBO1

1.67e-051681426315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_ventral_progenitors|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

RNASEH2B PHF19 GTSE1 WDR76 ZBED4 USP1

1.78e-05170142673601c873b177d5d134618d8e228c51381119f7d
ToppCell356C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PHF19 NEXMIF MSH2 WDR76 HOXB5 CELSR2

1.84e-051711426b113fbebb89056af0b9c775d2fb6552206a80467
ToppCellCOVID-19-Heart-Fib_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

LAMB1 SVEP1 TGFBR3 LMX1A NAV1 ROBO1

2.87e-0518514268f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMX1A SCN1A SCN2A SCN8A SYN2 CACNA1I

3.05e-0518714267b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

ADAMTS3 NLGN1 DENND2B SCN1A NCOA7 MAP3K13

3.14e-051881426ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellControl-Endothelial-Endothelial-FOXM1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHF19 GTSE1 WDR76 DBF4 SYCP1 CEP152

3.23e-0518914261e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLCO4A1 DENND2B NEDD4 TGFBR3 STARD9 SH3BP5

3.33e-0519014260e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD4 TGFBR3 SYT15B STARD9 NAV1 SH3BP5

3.43e-051911426f663131a4810584c5854bd64ee7991a237b7707f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

IST1 BAZ2A PHF3 DBF4 CRYBG1 SNX9

3.43e-0519114261ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLCO4A1 DENND2B NEDD4 TGFBR3 STARD9 SH3BP5

3.43e-051911426f229abf69a1217194f74b0502486907e07dba989
ToppCellRV-01._Fibroblast_I|World / Chamber and Cluster_Paper

LAMB1 SVEP1 TGFBR3 STARD9 NCOA7 ROBO1

3.43e-05191142670c067c54084bfb02c29bab085f4defd477194fb
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

DVL3 SUSD1 ABCA5 NFATC4 USP32 RBM6

3.43e-051911426c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

AZIN2 LAMB1 SVEP1 TGFBR3 LMX1A ROBO1

3.74e-051941426d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 ENPP1 TGFBR3 HOXB5 ROBO1 PHLDB2

3.85e-0519514262514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCellB_cell_maturation-CD34+_pro-B|World / Lineage and Cell class

SOX4 RNASEH2B GTSE1 SSRP1 USP1 TOP2B

3.96e-0519614264cb046883e56524963f6469ddb3b82c3c9853379
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 ENPP1 TGFBR3 HOXB5 ROBO1 PHLDB2

3.96e-051961426e4d04e1f82779e8afd4e32bbe38d1d3f6f64ab50
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 ENPP1 TGFBR3 HOXB5 ROBO1 PHLDB2

3.96e-051961426f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 ENPP1 LAMB1 NEDD4 HOXB5 ROBO1

4.08e-05197142626475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SOX4 ENPP1 LAMB1 NEDD4 HOXB5 ROBO1

4.08e-051971426155e63b33302a87393ace699b2f6d73abe9c5763
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-0519914264394dcd1809f49e9bada8f5e115d5123356eae3e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PHF19 GTSE1 MSH2 STIL WDR76 USP1

4.31e-051991426e98ff036d04fc78dffef156bdc0d644532274067
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PHF19 GTSE1 MSH2 STIL WDR76 USP1

4.31e-051991426305a9ade5bbe8e981e7c641c9a5e0c9f8ef60470
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-051991426c0ea391bb347b99b94b5d7f02612ede938986745
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHF19 GTSE1 MSH2 STIL WDR76 USP1

4.31e-0519914267feedb0bf84a3361c8ab5b6674ff64e8ff140c23
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-05199142696af1f289552f38f2dfa181192eb3276f4c7d70b
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 GTSE1 MSH2 STIL WDR76 USP1

4.31e-051991426123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCellremission-T/NK_proliferative|World / disease stage, cell group and cell class

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-051991426f305f3a454b7d2170429bad087480ccccca19acd
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 GTSE1 MSH2 STIL WDR76 USP1

4.31e-051991426fba48342066aab41a8bcb20db40a6df0158e1cbe
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADAMTS3 LAMB1 SVEP1 PTK7 TGFBR3 ROBO1

4.31e-05199142630d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-T/NK_proliferative|COVID-19_Convalescent / Disease group, lineage and cell class

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-051991426893b78c661c529db07a5fcc3124d9b3d0f270fa5
ToppCellCOVID-19_Convalescent-T/NK_proliferative|COVID-19_Convalescent / Disease condition and Cell class

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-051991426c608d953b852b67a4e36bd63d45f0deec3eefbd9
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 GTSE1 MSH2 STIL WDR76 USP1

4.31e-0519914266b1304417cf9c44ca70d2bfc2b5acc1a206f25b6
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

PHF19 GTSE1 STIL DBF4 CEP152 USP1

4.31e-051991426d8f904f531bfe091b7d8caaa147ea4a03d627995
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-0519914265b18e18ddbf4bd53aa0d574d23092cb96da7f400
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-Other_T|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-0519914266df65f4c2f9a125e0c7c4f597fefc05a97fc8831
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-Other_T|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.31e-051991426cb229aa3eb7b1cc47e76711b8fc18fce88a5cf08
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

PHF19 GTSE1 STIL WDR76 DBF4 CEP152

4.43e-0520014268f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

RNASEH2B MRE11 PHF19 SLCO4A1 CEP152 USP1

4.43e-052001426d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells|10w / Sample Type, Dataset, Time_group, and Cell type.

PHF19 GTSE1 STIL WDR76 DBF4 CEP152

4.43e-052001426a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX4 NLGN1 ZNF804A PTPRZ1 SCN1A SCN2A

4.43e-052001426f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX4 NLGN1 ZNF804A PTPRZ1 SCN1A SCN2A

4.43e-052001426cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ENPP1 LAMB1 SVEP1 TGFBR3 MKX ROBO1

4.43e-052001426a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX4 NLGN1 ZNF804A PTPRZ1 SCN1A SCN2A

4.43e-052001426c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell|GW13 / Sample Type, Dataset, Time_group, and Cell type.

RNASEH2B MRE11 PHF19 SLCO4A1 CEP152 USP1

4.43e-0520014263d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron|10w / Sample Type, Dataset, Time_group, and Cell type.

SOX4 ATL1 ABCA5 SCN2A NAV1 SH3BP5

4.43e-052001426f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMB1 SVEP1 TGFBR3 STARD9 NAV1 PHLDB2

4.43e-052001426b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ENPP1 LAMB1 SVEP1 TGFBR3 STARD9 PHLDB2

4.43e-052001426c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX4 NLGN1 ZNF804A PTPRZ1 SCN1A SCN2A

4.43e-0520014264fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-T/NK_proliferative|COVID-19_Convalescent / Disease, condition lineage and cell class

PHF19 GTSE1 STIL SSRP1 WDR76 USP1

4.43e-05200142600538c4cbab5da00b3a366717d38a3ba5cfe3f65
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX4 NLGN1 ZNF804A PTPRZ1 SCN1A SCN2A

4.43e-052001426310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMB1 SVEP1 TGFBR3 STARD9 NAV1 PHLDB2

4.43e-0520014260c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

SOX4 NLGN1 ZNF804A PTPRZ1 SCN1A SCN2A

4.43e-052001426961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RIPOR2 AZIN2 SLCO4A1 PTPRZ1 KIAA2012

7.54e-051361425186be8e1595608004b8216892cb9c7a7f31fbb4d
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

NLGN1 MTMR3 IPO13 MAP3K13 PADI3

7.80e-051371425b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCell(08)_PNEC-(2)_48hpi|(08)_PNEC / shred by cell type and Timepoint

SPAST ZFYVE16 ENPP1 CLCN5 MAP3K13

9.24e-051421425e95d34170f5053678e0dd9793e68d93c03b05822
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PHF19 ADAMTS3 GTSE1 SCN2A CRYBG1

1.12e-04148142518cfecd6ae20edb74f5d44ba759909df356acf3a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EXO5 ZFYVE16 SCN1A SCN2A MKX

1.23e-041511425f41c6558a5874b6464c157027fdf202257c60e5b
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DENND2B NACAD FBXW8 NFATC4 NAV1

1.48e-041571425432b8719a8afd289cf48068e12c26a349d753fcc
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-2|TCGA-Lung / Sample_Type by Project: Shred V9

EXO5 PHF19 MSH2 STIL USP1

1.52e-0415814259dea15b28f64206bac0e785df6f36a2cc9010ac7
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB1 NLGN1 NACAD SCN2A CRYBG1

1.57e-04159142550d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DCST1 SVEP1 FASN LMX1A MKX

1.66e-041611425a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 GTSE1 SUSD1 SCN4A CACNA1I

1.71e-041621425e81dec1db8e5a808d96e58410c91961e5d065c94
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 GTSE1 SUSD1 SCN4A CACNA1I

1.71e-041621425d19b469f64c9064cfb82dadb6c8135e28949a02a
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 GTSE1 SUSD1 SCN4A CACNA1I

1.71e-04162142510c2aa047f33f48e4abe676236bbdb593079dd1d
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NEDD4 PARP4 MDN1 USP1 CRAMP1

1.76e-041631425130c84bca3f72ab7d1a4fee2990c3d01600318ed
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

GTSE1 LAMB1 SVEP1 NAV1 NLGN2

1.81e-0416414252ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 GTSE1 USP32 CEP152 ERICH6

1.87e-04165142584eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GTSE1 STIL SSRP1 WDR76 USP1

1.87e-04165142588681101d7cf60b99b8ace5d8c0944323b937306
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RIPOR2 STIL SUSD1 MAD1L1 CRAMP1

1.87e-04165142566f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 GTSE1 USP32 CEP152 ERICH6

1.87e-041651425af59a095ecc6758abc13d763c00e44447c488167
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

INTS12 ZNF804A TGFBR3 SERPINI2 LMX1A

2.03e-041681425fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DENND2B SVEP1 NFATC4 ROBO1 SH3BP5

2.03e-041681425d19a115365c5415e51c039718d7669de788fcf33
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

INTS12 ZNF804A TGFBR3 SERPINI2 LMX1A

2.03e-041681425e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SPG11 IFIH1 RBM6 IPO13 PHLDB2

2.09e-041691425665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SPG11 IFIH1 RBM6 IPO13 PHLDB2

2.09e-0416914256614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell390C-Lymphocytic-NK_cells-Proliferating_NK_cell|390C / Donor, Lineage, Cell class and subclass (all cells)

PHF19 MYO1H GTSE1 STIL WDR76

2.14e-0417014255319f73cff64f2bb67472c7156ee1d0f006c6fc0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC4 MKX NIPAL2 ROBO1 SH3BP5

2.14e-04170142599dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC4 MKX NIPAL2 ROBO1 SH3BP5

2.14e-0417014253a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NFATC4 MKX NIPAL2 ROBO1 SH3BP5

2.14e-041701425cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX4 PTPRZ1 NIPAL2 NCOA7 CRAMP1

2.20e-041711425ea60d9e9df28ab991fbdb596784b44f6a9fc5827
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRE11 PHF19 GTSE1 STIL WDR76

2.26e-0417214252b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell10x5'-Lung-Myeloid_Dendritic-Cycling_Dendritic|Lung / Manually curated celltypes from each tissue

AZIN2 ENPP1 MEIKIN GTSE1 STIL

2.32e-04173142562e0c18cfed9645e34a9d7029c94a8554f773714
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZBTB22 IFIH1 C2CD3 USP32 NCOA7

2.45e-041751425334fad1a147de6c007cec5089c02c35cf3220f1b
ToppCellICU-SEP-Myeloid-cDC2|ICU-SEP / Disease, Lineage and Cell Type

SWT1 ENPP1 IFIH1 ZC3H4 NAV1

2.45e-041751425c44fd1cc827296de7300d4a60399bb945089a170
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZBTB22 IFIH1 C2CD3 USP32 NCOA7

2.45e-041751425da191dfb8a7f976a632a3a0b923942ab54f5c8c1
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN4A SCN8A SCN10A

1.98e-0861394ctd:C475726
DrugAPETx2 protein, Anthopleura elegantissima

SCN2A SCN8A SCN10A

8.87e-0741393ctd:C501880
DrugZonisamide

SCN1A SCN2A SCN4A CACNA1I

2.98e-06171394DB00909
DrugHydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT_HG-U133A

SOX4 SPAST ADAMTS3 PTK7 ZBED4 BAZ2A PHACTR4 CEP152 CABIN1

3.38e-0619613992119_DN
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN8A SCN10A

1.22e-0581393ctd:C489827
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN10A

5.53e-10101405DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN10A

5.53e-10101405DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN10A

1.73e-09121405DOID:0060170 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

SPAST NEXMIF PTK7 ZC3H4 SCN1A SCN2A SCN8A

3.14e-07931407C1535926
Diseaseautism spectrum disorder (implicated_via_orthology)

NEXMIF CHD8 NLGN1 SCN1A SCN2A SYN2 NLGN2

8.49e-061521407DOID:0060041 (implicated_via_orthology)
DiseaseIntellectual Disability

SOX4 RNASEH2B APC CHD8 ATL1 FASN MTF1 BBS7 SCN1A SCN8A MED13

1.00e-0544714011C3714756
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

TDRD15 MYO1H POLR2M SPG11 CELSR2 SCN8A RBM6 SYN2 USP1

1.52e-053031409EFO_0004612, EFO_0020945
Diseaseesterified cholesterol measurement, low density lipoprotein cholesterol measurement

TDRD15 ADAMTS3 CELSR2

3.66e-05141403EFO_0004611, EFO_0008589
DiseaseProfound Mental Retardation

APC CHD8 FASN BBS7 SCN1A SCN8A

5.48e-051391406C0020796
DiseaseMental Retardation, Psychosocial

APC CHD8 FASN BBS7 SCN1A SCN8A

5.48e-051391406C0025363
DiseaseMental deficiency

APC CHD8 FASN BBS7 SCN1A SCN8A

5.48e-051391406C0917816
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

6.68e-0531402cv:C5575231
Diseaseepilepsy (implicated_via_orthology)

SCN1A SCN2A SCN4A SCN8A SCN10A SYN2

1.32e-041631406DOID:1826 (implicated_via_orthology)
Diseasediet measurement

TDRD15 CCDC8 MYO1H MSH3 NLGN1 SERPINI2 CELSR2 SCN2A MAD1L1 RBM6 ROBO1 PRKDC CAMTA1 NMBR SH3BP5

1.44e-04104914015EFO_0008111
Diseasemigraine disorder, type 2 diabetes mellitus

NLGN1 MAD1L1 NCOA7 KIAA2012

1.93e-04601404MONDO_0005148, MONDO_0005277
DiseaseHypophosphatemic rickets

ENPP1 CLCN5

2.21e-0451402cv:C1704375
DiseaseHereditary hypophosphatemic rickets

ENPP1 CLCN5

2.21e-0451402cv:CN296404
DiseaseTurcot syndrome (disorder)

APC MSH2

2.21e-0451402C0265325
DiseaseRickets

ENPP1 CLCN5

2.21e-0451402cv:C0035579
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

APC MSH2 MSH3

2.51e-04261403C0009405
DiseaseAicardi-Goutieres Syndrome 2

RNASEH2B IFIH1

3.31e-0461402C3489724
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

3.31e-0461402C0220669
DiseaseAICARDI-GOUTIERES SYNDROME 1

RNASEH2B IFIH1

3.31e-0461402C0796126
DiseaseHereditary Nonpolyposis Colorectal Cancer

APC MSH2 MSH3

3.49e-04291403C1333990
DiseasePseudo-TORCH syndrome

RNASEH2B IFIH1

4.62e-0471402C3489725
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

4.62e-0471402C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

4.62e-0471402C0751057
Diseaselobe attachment

POLR2M CRYBG1 ROBO1 PRKDC NMBR PHLDB2

4.77e-042071406EFO_0007667
Diseaseesterified cholesterol measurement, intermediate density lipoprotein measurement

TDRD15 CELSR2

6.14e-0481402EFO_0008589, EFO_0008595
Diseaseguanosine monophosphate measurement

SLCO4A1 SH3BP5

6.14e-0481402EFO_0010495
DiseaseAICARDI-GOUTIERES SYNDROME

RNASEH2B IFIH1

6.14e-0481402C0393591
DiseaseHDL cholesterol change measurement, response to simvastatin, response to fenofibrate

MSH3 TGFBR3

6.14e-0481402EFO_0007805, GO_1901557, GO_1903491
Diseaseovarian cancer (implicated_via_orthology)

MRE11 APC

6.14e-0481402DOID:2394 (implicated_via_orthology)
DiseaseEpilepsy, Cryptogenic

NEXMIF SCN1A SCN2A SCN8A

6.37e-04821404C0086237
DiseaseAwakening Epilepsy

NEXMIF SCN1A SCN2A SCN8A

6.37e-04821404C0751111
DiseaseAura

NEXMIF SCN1A SCN2A SCN8A

6.37e-04821404C0236018
Diseaseendometrial cancer (is_implicated_in)

MRE11 APC MSH3

6.66e-04361403DOID:1380 (is_implicated_in)
DiseaseLynch Syndrome

APC MSH2

7.87e-0491402C4552100
DiseaseFebrile Convulsions

SCN1A SCN2A

7.87e-0491402C0009952
DiseaseAicardi-Goutieres syndrome (is_implicated_in)

RNASEH2B IFIH1

7.87e-0491402DOID:0050629 (is_implicated_in)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

7.87e-0491402C3502809
DiseaseInherited neuropathies

MRE11 SPAST SPG11

9.08e-04401403C0598589
Diseasecholate measurement

CCDC8 ERICH6

9.81e-04101402EFO_0021509
DiseaseAdenocarcinoma of large intestine

APC MSH2 PTK7 PRKDC

1.15e-03961404C1319315
Diseasestatus epilepticus (biomarker_via_orthology)

NLGN1 OSBPL2 PTPRZ1 NLGN2

1.34e-031001404DOID:1824 (biomarker_via_orthology)
Diseaseendometrial carcinoma (is_implicated_in)

APC MSH3

1.43e-03121402DOID:2871 (is_implicated_in)
Diseasepulmonary function measurement, forced expiratory volume, smoking behaviour measurement

INTS12 PADI3

1.43e-03121402EFO_0003892, EFO_0004314, EFO_0005671
Diseasecardiovascular disease

TDRD15 SVEP1 IRX4 ATL1 HOXB5 CELSR2 MAD1L1 NAV1

1.57e-034571408EFO_0000319
DiseaseAutistic Disorder

APC LAMB1 CHD8 NLGN1 MTF1 ROBO1

1.58e-032611406C0004352
Diseaselipoprotein measurement

TDRD15 MYO1H NFATC4 USP1

1.60e-031051404EFO_0004732
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

1.68e-03131402C0751122
DiseaseEpilepsy

NEXMIF SCN1A SCN2A SCN8A

1.84e-031091404C0014544
DiseaseMalignant neoplasm of breast

MRE11 SPAST DVL3 FAM131A NEDD4 PPARGC1B FASN TRAPPC12 MTMR3 ROBO1 MAP3K13 NMBR PADI3

1.85e-03107414013C0006142
DiseaseMMR-related febrile seizures

SCN1A SCN2A

2.25e-03151402EFO_0006519
DiseaseAutosomal recessive primary microcephaly

STIL CEP152

2.25e-03151402cv:C3711387
Diseaseresponse to statin, LDL cholesterol change measurement

TDRD15 CELSR2

2.25e-03151402EFO_0007804, GO_0036273
Diseasephospholipids in medium HDL measurement

MYO1H CELSR2 USP1

2.29e-03551403EFO_0022295
DiseasePolyposis, Adenomatous Intestinal

APC MSH3

2.57e-03161402C2713442
DiseaseFamilial Intestinal Polyposis

APC MSH3

2.57e-03161402C2713443
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

2.57e-03161402C0393706
Diseasetotal lipids in medium HDL measurement

MYO1H CELSR2 USP1

2.67e-03581403EFO_0022310
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

TDRD15 SPG11 CELSR2 USP1

2.69e-031211404EFO_0008595, EFO_0020943
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

TDRD15 MYO1H SPG11 CELSR2 USP1

2.71e-032001405EFO_0004611, EFO_0020945
DiseaseProstatic Neoplasms

RPN2 APC MSH3 PPP2R2A BAZ2A MAD1L1 NCOA7 ROBO1 PRKDC

2.77e-036161409C0033578
DiseaseMalignant neoplasm of prostate

RPN2 APC MSH3 PPP2R2A BAZ2A MAD1L1 NCOA7 ROBO1 PRKDC

2.77e-036161409C0376358
DiseaseLipidemias

APC PPARGC1B

2.90e-03171402C1706412
DiseaseAdenomatous Polyposis Coli

APC MSH3

2.90e-03171402C0032580
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

TDRD15 CELSR2

2.90e-03171402EFO_0022232
DiseaseHyperlipidemia

APC PPARGC1B

2.90e-03171402C0020473
DiseaseObesity

ENPP1 HOXB5 PPARGC1B FASN BBS7

3.01e-032051405C0028754
Diseasephospholipids in HDL measurement

MYO1H CELSR2 USP1

3.08e-03611403EFO_0022293
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

3.25e-03181402HP_0002373
DiseaseTourette syndrome, schizophrenia

PHF3 CACNA1I

3.25e-03181402EFO_0004895, MONDO_0005090
Diseasevery low density lipoprotein cholesterol measurement, esterified cholesterol measurement

TDRD15 CELSR2

3.25e-03181402EFO_0008317, EFO_0008589
DiseaseMalignant Neoplasms

MRE11 APC MSH3 FASN

3.29e-031281404C0006826
Diseasehemoglobin A1 measurement

ENPP1 SLCO4A1 WDR76 MTF1 ZC3H4 MAD1L1 MTMR3 SYN2

3.47e-035201408EFO_0007629
Diseasecholine measurement

TDRD15 MYO1H CELSR2 NFATC4

3.48e-031301404EFO_0010116
Diseaseresponse to methotrexate, juvenile idiopathic arthritis

LMX1A CACNA1I

3.63e-03191402EFO_0002609, GO_0031427
DiseaseBrugada syndrome

SCN10A NCOA7

3.63e-03191402MONDO_0015263
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

MSH2 MSH3

3.63e-03191402C2936783
Diseasebreast carcinoma (is_marker_for)

SOX4 MRE11 MSH2

3.85e-03661403DOID:3459 (is_marker_for)
Diseasebipolar disorder, schizophrenia, response to lithium ion

MYO1H ZNF804A

4.02e-03201402GO_0010226, MONDO_0004985, MONDO_0005090
Diseasedisease

NLGN1 MAD1L1

4.42e-03211402EFO_0000408

Protein segments in the cluster

PeptideGeneStartEntry
ADSDISDLISFFTSQ

ABCA5

921

Q8WWZ7
SDLRAFFSNVDVSSE

ERICH6

276

Q7L0X2
VVSFSSCDSESNDNF

BBS7

426

Q8IWZ6
EEEASAVSTAAAQFT

CHD8

2226

Q9HCK8
SSSATLSFDSREASF

CEP152

1576

O94986
SLDHFDISFSNQFSD

CAMTA1

761

Q9Y6Y1
SNRSFFSEIISSISD

PPP2R2A

276

P63151
SVASEAFEDDSCSNF

SH3BP5

296

O60239
FSLLADDSQTSTSIF

BAZ2A

351

Q9UIF9
SQATTDEVAAFFVAD

AZIN2

31

Q96A70
TVDEDSSGSEFLFFN

CELSR2

2906

Q9HCU4
SDDSSDLLDFALSAS

AHDC1

846

Q5TGY3
GESFALSFSSASDAE

ARL2BP

6

Q9Y2Y0
LSFSSASDAEFDAVV

ARL2BP

11

Q9Y2Y0
SRKSFEFEDASSLQS

DENND2B

446

P78524
TTSFFDSDEDDSTSR

DVL3

186

Q92997
EEENSDNLLTAFFSS

DBF4

651

Q9UBU7
TETVAANSSFSQSFA

ARR3

256

P36575
TAAAAAATSLSQTEF

IRX4

376

P78413
ADLSSFEETSADDFA

INTS12

141

Q96CB8
FQASVDSFSPSDVFD

KIAA1107

946

Q9UPP5
SAEASGFSDLSDSEF

EXO5

11

Q9H790
VFDSFQDSASRSELE

MSH3

401

P20585
FDSSSLSASLNIFQE

MDN1

561

Q9NU22
FSEVARISSLDNSSF

NMBR

181

P28336
NSALAAEASEESLFS

HSFY1

226

Q96LI6
SAEQSFLFSREEADT

MAD1L1

486

Q9Y6D9
QSSNVLADSDDASFT

NEDD4

101

P46934
FSFSSDLQSTQASSL

LGALS8

151

O00214
FTFTISSLEAEDAAT

IGKV6D-41

91

A0A0C4DH26
FDTSSDVLAQQFAST

DCAF4L1

221

Q3SXM0
ALSQDDATVATASAF

FBXW8

306

Q8N3Y1
SGSFSSNEFEEELVS

MKX

251

Q8IYA7
FQSAIDTSASFSSLL

LMX1A

11

Q8TE12
EDTSNRGSFASDSFV

KIAA2012

911

Q0VF49
ESETAASEETLFNAS

LAMB1

1631

P07942
SLTSEDSFFSATELF

MIGA2

286

Q7L4E1
DSFFSATELFESLQT

MIGA2

291

Q7L4E1
QFSNVSAIFSTSSED

MEIKIN

191

A0A087WXM9
TVDRNDSFSTEDFSN

ENPP1

696

P22413
ISASDFDFAVSNFVD

NLGN1

446

Q8N2Q7
SDSLNENETSTDFSF

PTPRZ1

1556

P23471
ENETSTDFSFADTNE

PTPRZ1

1561

P23471
FAFQSSDTESDELSE

PARP4

1516

Q9UKK3
SFHVTLLDDSNEDFS

PADI3

266

Q9ULW8
AHSLLFENSDSFSED

PHACTR4

441

Q8IZ21
FENSDSFSEDSSTLG

PHACTR4

446

Q8IZ21
KFDFDLSLSSSSANE

GTSE1

16

Q9NYZ3
LSLSSSSANEDDEVF

GTSE1

21

Q9NYZ3
AFSSSRDLASSRDDF

FAM171A2

401

A8MVW0
ATSASSSANFTEIDE

HOXB5

121

P09067
SSANFTEIDEASASS

HOXB5

126

P09067
STFSSENFSVSDGEE

MAP3K13

846

O43283
AASFFAASDSIGASS

ADAMTS3

1166

O15072
AFSDSSSIGSVLDDA

CEFIP

11

Q711Q0
SSSDQSFASFDDQQK

CEFIP

731

Q711Q0
LDATSIDDNTSFFLN

IGSF1

366

Q8N6C5
FDSQSTLRDSATVFA

ATL1

151

Q8WXF7
VALSDSSSTQDFFNE

CABIN1

1381

Q9Y6J0
NEAATSELGDSADSF

C2CD3

2211

Q4AC94
DQDFAVSFAEDASSS

DEFA6

46

Q01524
SSSAFSDSNDDTAYA

DCST1

691

Q5T197
AETEAFSLNSDRSSS

CACNA1I

1851

Q9P0X4
FSDSFSFINEEDSLL

CENPJ

61

Q9HC77
LEQAADEISFSSNSS

CENPJ

581

Q9HC77
GSFSSFQNSSSDEDL

CLCN5

16

P51795
DSTDSSLSSLFASFI

CRAMP1

1156

Q96RY5
ENNSSESSFADSSVV

IFIH1

241

Q9BYX4
AALESAFSSYSDLSE

FAM131A

146

Q6UXB0
AADSLDFDETFLATS

FOXJ1

366

Q92949
ASAGASTSASEDIDF

IST1

336

P53990
SFQSELTASASADYE

C2orf66

91

Q6UXQ4
DQASEFSASFSDVRI

DBR1

456

Q9UK59
FSSDLSFSASRFTVE

CCDC168

211

Q8NDH2
SFSASRFTVENEDLD

CCDC168

216

Q8NDH2
FSSSTQDSFQSQDLD

CCDC168

351

Q8NDH2
NISAGSDDSVFDSSS

CRYBG1

681

Q9Y4K1
FSSISAALEDSQSSF

COG2

546

Q14746
RLSFSDSESDNSADS

MLLT1

436

Q03111
TNTTFDFDLFSLDET

MLLT1

531

Q03111
AEDTSSSFDNLFIDR

POLR2M

181

P0CAP2
DSTSFANSRDTSFEQ

FASN

1716

P49327
TYDSSNASDSEFSDF

CCDC8

96

Q9H0W5
NASDSEFSDFETSRD

CCDC8

101

Q9H0W5
AFAALQDSELFDSSV

IPO13

246

O94829
SDDSNFGQFELTTFD

MSH2

281

P43246
VSASAFDFTVSNFVD

NLGN2

401

Q8NFZ4
DLSDVEFDSSLSNAS

MTMR3

286

Q13615
VQDSFSFLEDSSSSE

ARHGAP30

506

Q7Z6I6
IASTDSFASAAELAE

MIGA1

321

Q8NAN2
SDASDNLSSEEFNAS

NAV1

421

Q8NEY1
ESSFFRSSANEDEAK

SYN2

551

Q92777
SSSDFQSRDSSQLDF

RBM6

101

P78332
DQAFLDSLSASTAQA

SNX9

76

Q9Y5X1
SFSSSSALDRDLDFN

SOX4

421

Q06945
FVTDGNFDSASSLNS

TRMT1L

96

Q7Z2T5
LLSSFSADSLAASDE

SCN4A

801

P35499
SAKFDSNEEDSASVF

TOP2B

1461

Q02880
FQDASKSGSLDDSFS

SYNRG

461

Q9UMZ2
ETSVSDVNSFAVESF

TDRD15

436

B5MCY1
DTSSAFESTAKENFL

NCOA7

396

Q8NI08
LSSWSFFSDASDEAA

NFATC4

176

Q14934
ASLTESFNGDAESVS

MTF1

391

Q14872
NSLETSGSFSDDSSF

NEXMIF

431

Q5QGS0
DSASAALDELSLNFT

NIPAL2

11

Q9H841
VFEDSSSSSGESSFL

PPARGC1B

791

Q86YN6
AAESNATFFNISAAS

SPAST

396

Q9UBP0
FSTSEDFASEAEVAV

STARD9

2456

Q9P2P6
VKFSSVSDGFNSDST

MED13

346

Q9UHV7
SALTTSNIASFEEAF

SWT1

781

Q5T5J6
SQSEESASAFSADDL

MRE11

531

P49959
TSSCASDDFDQASYV

PHLDB2

346

Q86SQ0
SSFSSTFSAAEESVV

SVEP1

1161

Q4LDE5
EFFDAVTGFDSDNSS

OSBPL2

6

Q9H1P3
NLFDSSVFDTEISSD

SIX6OS1

486

Q8N1H7
FSSFSELSSASEEDD

SRBD1

21

Q8N5C6
TVESALESFDFLNTS

RIPOR2

656

Q9Y4F9
LLSSFSADNLAATDD

SCN1A

991

P35498
ESQFSLSASEAATLF

SLCO4A1

411

Q96BD0
VAEEFDSNASASSSS

SSRP1

491

Q08945
ALAELDSVFSSAATS

AGFG1

376

P52594
FSRNDSLSSLDFDDD

APC

1856

P25054
SEASLLSADSSSQAF

ATF6B

176

Q99941
ELSFDSLASEFSFSK

SPG11

1831

Q96JI7
ANNSTFFSISSSDLV

VPS4B

191

O75351
SAESQNAETEFFSKA

STIL

356

Q15468
STAFFSGDQASTDKE

RNASEH2B

191

Q5TBB1
SHSLASDFFDSFTTS

TRAPPC12

216

Q8WVT3
SDFFDSFTTSAFISV

TRAPPC12

221

Q8WVT3
FESLSEAFSVASAAA

RPN2

246

P04844
TQFITFSALSDFADT

SCN10A

1756

Q9Y5Y9
FEFDINSDSSETTDL

SYCP1

886

Q15431
SEGASSFFSNASDAD

SUSD1

636

Q6UWL2
DAFSDVAFKSQQSTS

ZNF398

291

Q8TD17
TFSFKADATELDTAS

SYT15B

401

X6R8R1
AATEDSFDSTTYSFR

ZNRF4

356

Q8WWF5
QAAAAAASAESRDFS

SCN2A

461

Q99250
ADALSSTSNILASEF

PHF3

1156

Q92576
ASSGQTFFSDVDSTD

PHF19

436

Q5T6S3
TFFSDVDSTDAASTS

PHF19

441

Q5T6S3
LLSSFSADNLAATDD

SCN8A

976

Q9UQD0
FFEINEDGSEAATST

SERPINI2

336

O75830
SSSDGSFFTDADFAQ

ROBO1

1391

Q9Y6N7
SSSDDFSDFSDDSDF

ZC3H4

131

Q9UPT8
ADEAFFSVNSSSESL

PRKDC

546

P78527
LFLNDTSAFDFSDEA

SLC30A4

21

O14863
SENADFFASLQLSES

WDR76

171

Q9H967
NERSSFSSFDFLAED

WDR76

401

Q9H967
FSSFDFLAEDASTLI

WDR76

406

Q9H967
SSQNFTLSIADESFA

PTK7

211

Q13308
DFSSSSQEAFAASAV

ZBTB22

216

O15209
FSDNISTASEASETA

USP32

461

Q8NFA0
ASTAFAENRNSETSD

USP1

691

O94782
SKINDDDSFTTFFSE

TUBA8

41

Q9NY65
QFSSANFSLTAETEE

TGFBR3

136

Q03167
TSGSFTLDDDVFAET

ZFYVE16

961

Q7Z3T8
ATEANNSTFFSVSSS

VPS4A

181

Q9UN37
LESSAAAFSEYSDDA

ZNF804A

226

Q7Z570
VAAFSSSDDIGEASA

ZBED4

411

O75132
SNLFSTAEVDLADDS

NLRP13

461

Q86W25
TVSNAFSVIDFTEAD

MYO1H

251

Q8N1T3
EAFAFRDDTSAASSD

NACAD

376

O15069
AASSDSDSASYAEAD

NACAD

386

O15069