Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribosomal protein S6 kinase activity	RPS6KA3 RPS6KB2 RPS6KA6	6.49e-07	7	54	3	GO:0004711
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3C EIF3CL	2.33e-04	9	54	2	GO:0071541
GeneOntologyCellularComponent	dynein complex	DYNLT2 NME8 DNAH1	3.68e-04	54	54	3	GO:0030286
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex	EIF3C EIF3CL	7.68e-04	16	54	2	GO:0005852
GeneOntologyCellularComponent	microtubule associated complex	APPBP2 DYNLT2 NME8 DNAH1	7.94e-04	161	54	4	GO:0005875
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN10A CACNA1H	8.69e-04	17	54	2	GO:0001518
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF3C EIF3CL	9.76e-04	18	54	2	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF3C EIF3CL	1.09e-03	19	54	2	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF3C EIF3CL	1.21e-03	20	54	2	GO:0070993
GeneOntologyCellularComponent	axonemal dynein complex	NME8 DNAH1	1.89e-03	25	54	2	GO:0005858
Domain	EIF3C_N_dom	EIF3C EIF3CL	7.90e-06	2	53	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	7.90e-06	2	53	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	7.90e-06	2	53	2	IPR027516
Domain	Ribosomal_S6_kinase_II	RPS6KA3 RPS6KA6	1.18e-04	6	53	2	IPR016239
Domain	Pkinase_C	RPS6KA3 RPS6KB2 RPS6KA6	1.57e-04	37	53	3	IPR017892
Domain	Pkinase_C	RPS6KA3 RPS6KB2 RPS6KA6	2.29e-04	42	53	3	PF00433
Domain	AGC-kinase_C	RPS6KA3 RPS6KB2 RPS6KA6	5.38e-04	56	53	3	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA3 RPS6KB2 RPS6KA6	5.38e-04	56	53	3	PS51285
Domain	S_TK_X	RPS6KA3 RPS6KB2 RPS6KA6	5.38e-04	56	53	3	SM00133
Domain	PINT	EIF3C EIF3CL	9.24e-04	16	53	2	SM00088
Domain	Crotonase_core_superfam	EHHADH CDYL2	1.05e-03	17	53	2	IPR001753
Domain	PCI_dom	EIF3C EIF3CL	1.05e-03	17	53	2	IPR000717
Domain	PCI	EIF3C EIF3CL	1.05e-03	17	53	2	PF01399
Domain	ECH_1	EHHADH CDYL2	1.05e-03	17	53	2	PF00378
Domain	-	EHHADH CDYL2	1.60e-03	21	53	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	EHHADH CDYL2	1.60e-03	21	53	2	IPR029045
Domain	DEP	PLEK2 GPR155	1.76e-03	22	53	2	PF00610
Domain	DEP	PLEK2 GPR155	1.76e-03	22	53	2	PS50186
Domain	DEP	PLEK2 GPR155	1.76e-03	22	53	2	SM00049
Domain	DEP_dom	PLEK2 GPR155	1.92e-03	23	53	2	IPR000591
Domain	FHA	AFDN MCRS1	2.85e-03	28	53	2	SM00240
Domain	-	PLEK2 GPR155 EIF3C EIF3CL	3.38e-03	218	53	4	1.10.10.10
Domain	FHA_DOMAIN	AFDN MCRS1	3.49e-03	31	53	2	PS50006
Domain	FHA	AFDN MCRS1	3.49e-03	31	53	2	PF00498
Domain	FERM_N	FRMD6 TLN2	3.94e-03	33	53	2	PF09379
Domain	FERM_N	FRMD6 TLN2	3.94e-03	33	53	2	IPR018979
Domain	FHA_dom	AFDN MCRS1	4.68e-03	36	53	2	IPR000253
Domain	-	AFDN MCRS1	4.68e-03	36	53	2	2.60.200.20
Domain	WHTH_DNA-bd_dom	PLEK2 GPR155 EIF3C EIF3CL	4.90e-03	242	53	4	IPR011991
Domain	FERM_M	FRMD6 TLN2	7.55e-03	46	53	2	PF00373
Pathway	REACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING	RPS6KA3 RPS6KA6	7.04e-05	5	38	2	MM15108
Pathway	WP_CYTOPLASMIC_RIBOSOMAL_PROTEINS	RPS4Y1 RPS6KA3 RPS6KB2 RPS6KA6	8.90e-05	88	38	4	M39495
Pathway	KEGG_MEDICUS_REFERENCE_ERK_RSK_SIGNALING	RPS6KA3 RPS6KA6	1.05e-04	6	38	2	M47936
Pathway	REACTOME_RSK_ACTIVATION	RPS6KA3 RPS6KA6	1.47e-04	7	38	2	M27369
Pathway	REACTOME_L1CAM_INTERACTIONS	RPS6KA3 SCN10A RPS6KA6 ITGA2	3.04e-04	121	38	4	M872
Pathway	KEGG_MTOR_SIGNALING_PATHWAY	RPS6KA3 RPS6KB2 RPS6KA6	3.65e-04	52	38	3	M7561
Pathway	REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S	RPS4Y1 EIF3C EIF3CL	7.03e-04	65	38	3	MM15416
Pathway	REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS	RPS6KA3 RPS6KA6	7.27e-04	15	38	2	MM15103
Pubmed	Inhibition of Cav 3.2 calcium channels: A new target for colonic hypersensitivity associated with low-grade inflammation.	SCN10A CACNA1H	2.46e-06	2	55	2	30714145
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	2.46e-06	2	55	2	36157221
Pubmed	The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function.	SCN10A CACNA1H	2.46e-06	2	55	2	25600872
Pubmed	Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma.	CSMD1 LARGE1	7.36e-06	3	55	2	27636103
Pubmed	Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.	VPS13D CSMD1	7.36e-06	3	55	2	20610895
Pubmed	Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease.	VMP1 VPS13D	7.36e-06	3	55	2	34019822
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	1.47e-05	4	55	2	10504338
Pubmed	Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis.	RPS6KA3 RPS6KA6	1.47e-05	4	55	2	12711546
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TOR2A RPS4Y1 RPS6KA3 RPS6KB2 RPS6KA6 EIF3C MMP20 EIF3CL	1.85e-05	730	55	8	34857952
Pubmed	mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.	RPS6KB2 AFDN	2.45e-05	5	55	2	32581239
Pubmed	The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.	RPS6KA3 RPS6KA6	2.45e-05	5	55	2	37068088
Pubmed	RSK2 is a modulator of craniofacial development.	RPS6KA3 RPS6KA6	2.45e-05	5	55	2	24416220
Pubmed	Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation.	RPS6KA3 RPS6KA6	2.45e-05	5	55	2	11160957
Pubmed	Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.	RPS6KA3 RPS6KA6	3.67e-05	6	55	2	12832467
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	APPBP2 KLHL7 EHHADH AFDN	4.01e-05	120	55	4	27565346
Pubmed	A genome-wide association study of hypertension and blood pressure in African Americans.	IPO7 CACNA1H	6.83e-05	8	55	2	19609347
Pubmed	Nectins localize Willin to cell-cell junctions.	FRMD6 AFDN	6.83e-05	8	55	2	22512338
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	IPO7 EHHADH RPS6KA3 AFDN EIF3C EDC4 EIF3CL	8.29e-05	665	55	7	30457570
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	8.78e-05	9	55	2	24003236
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	8.78e-05	9	55	2	21292980
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	1.10e-04	10	55	2	16286006
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	1.10e-04	10	55	2	8995409
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RPS6KA3 TLN2 AFDN MCRS1 EIF3C EIF3CL	1.41e-04	503	55	6	16964243
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	1.60e-04	12	55	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	1.60e-04	12	55	2	17581632
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3C EIF3CL	2.21e-04	14	55	2	18599441
Pubmed	A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.	NPC1 TOR2A	2.54e-04	15	55	2	20457914
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3C EIF3CL	2.54e-04	15	55	2	17322308
Pubmed	Large-scale concatenation cDNA sequencing.	RCOR1 VPS13D IFT20 SPRYD3 TLN2 CACNA1H	2.72e-04	568	55	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	RCOR1 VPS13D IFT20 SPRYD3 TLN2 CACNA1H	2.87e-04	574	55	6	8619474
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	EIF3C EIF3CL	3.29e-04	17	55	2	34752747
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	VPS13D KLHL7 RPS6KA3	3.61e-04	87	55	3	37495603
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RCOR1 SORCS2 TLN2	3.61e-04	87	55	3	12465718
Pubmed	Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.	CSMD1 LARGE1	4.13e-04	19	55	2	24165912
Pubmed	SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.	RCOR1 IPO7 AFDN	7.16e-04	110	55	3	28883622
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	NPC1 VMP1 VPS13D MCRS1 VPS29	7.54e-04	454	55	5	33226137
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	EIF3C EIF3CL	8.40e-04	27	55	2	11518254
Pubmed	SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166.	TLN2 ITGA2	9.04e-04	28	55	2	32801337
Pubmed	Primary Ciliary Dyskinesia	NME8 DNAH1	1.18e-03	32	55	2	20301301
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	TLN2 EIF3C	1.41e-03	35	55	2	24515614
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	EIF3C EIF3CL	1.49e-03	36	55	2	16097034
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	RPS6KA3 RPS6KA6	1.65e-04	11	32	2	1156
Drug	2,2-dimethyl-1,3-propanediamine	PDCL2 ITGA2	5.73e-06	2	55	2	CID000081770
Drug	nostocarboline	BCHE ITGA2	1.72e-05	3	55	2	CID005326150
Drug	NSC628058	BCHE ITGA2	1.72e-05	3	55	2	CID000431073
Drug	glycolamide	BCHE ITGA2	1.72e-05	3	55	2	CID000069021
Disease	Coffin-Lowry syndrome (implicated_via_orthology)	RPS6KA3 RPS6KA6	1.62e-05	4	49	2	DOID:3783 (implicated_via_orthology)
Disease	heterogeneous nuclear ribonucleoproteins C1/C2 measurement	EHHADH BCHE	5.64e-05	7	49	2	EFO_0801675
Disease	transcription factor IIIb 90 kda subunit measurement	EHHADH BCHE	1.21e-04	10	49	2	EFO_0020778
Disease	PR domain zinc finger protein 1 measurement	EHHADH BCHE	1.47e-04	11	49	2	EFO_0801904
Disease	RAC-beta serine/threonine-protein kinase measurement	EHHADH BCHE	2.08e-04	13	49	2	EFO_0021989
Disease	interleukin 10 measurement	IPO7 SORCS2 CDYL2	3.00e-04	78	49	3	EFO_0004750
Disease	Mechanical Allodynia	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C2936719
Disease	Allodynia	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C0458247
Disease	Hyperalgesia, Secondary	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C0751212
Disease	Hyperalgesia, Primary	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C0751211
Disease	Hyperalgesia, Thermal	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C0751214
Disease	Tactile Allodynia	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C0751213
Disease	Hyperalgesia	SCN10A CACNA1H ITGA2	3.73e-04	84	49	3	C0020429
Disease	pallidum volume change measurement, age at assessment	SORCS2 CSMD1	7.91e-04	25	49	2	EFO_0008007, EFO_0021494
Disease	Antihypertensive use measurement	VMP1 RPS6KA3 CACNA1H NFAT5	9.81e-04	265	49	4	EFO_0009927
Disease	Bipolar Disorder	EHHADH SORCS2 BCHE CSMD1 AFG1L	1.15e-03	477	49	5	C0005586
Disease	HOMA-IR	RCOR1 CSMD1	1.38e-03	33	49	2	EFO_0004501
Disease	coronary aneurysm	CSMD1 SLC25A48	1.55e-03	35	49	2	EFO_1000881
Disease	Primary ciliary dyskinesia	NME8 DNAH1	1.64e-03	36	49	2	cv:C0008780

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVFGVKVKNLEFGLQ	TDG	241	Q13569
GVIQKQKNIAGALAF	AFDN	676	P55196
VGILEINKKIFGNVT	DCAF17	201	Q5H9S7
ELGQFKKTQILVGVN	BCHE	336	P06276
KIFKGVLVAELVGVF	CEBPZOS	11	A8MTT3
LLKAFQIKGQADIFV	CSMD1	3411	Q96PZ7
VKEKFILGVEGQQLV	ADAM7	16	Q9H2U9
LKQLFENLFKNGVVV	AFG1L	226	Q8WV93
KEKAIQVGFVLGGFL	APPBP2	116	Q92624
RQKIVVIAKAFGLQA	CLYBL	226	Q8N0X4
VIGNKSVVQVKNFFV	RCOR1	411	Q9UKL0
VDVSQIKQGFIVVKG	EDC4	281	Q6P2E9
VLFKKKFGGVQELLN	OARD1	46	Q9Y530
AVFHKFKGQQVLGLV	LARGE1	256	O95461
KEKNFVGQILVFVLL	GPR155	436	Q7Z3F1
LKVLGQGSFGKVFLV	RPS6KA3	71	P51812
IKKIGVVVGNCFGFV	EHHADH	466	Q08426
VYKNGQIEAKFIGII	PDCL2	166	Q8N4E4
VFLKAFAVGVQQVLL	IPO7	291	O95373
LVFVKDKIFAVGGQN	KLHL7	476	Q8IXQ5
LKVLGQGSFGKVFLV	RPS6KA6	76	Q9UK32
QIQEGVIKFLLGDKV	OR52N2	301	Q8NGI0
VKNFLEKFVQGLDIG	ITGA2	191	P17301
IGKNFLKGTKVIFQE	NFAT5	466	O94916
KFGGIVVLAFAKSQI	NPC1	1206	O15118
QGQLIKKETFIPFGI	CYP2U1	471	Q7Z449
LGEGVIVKIKFNIIA	EIF3C	366	Q99613
NVGKLVFVGKKFEIL	FRMD6	276	Q96NE9
KIIGAFKNLVDINFV	DNAH1	2326	Q9P2D7
NLGEGVIVKIKFNII	EIF3CL	366	B5ME19
QIQKGKFQVVAIEGL	CMPK2	246	Q5EBM0
LLEKFVAVLGGNIKQ	DDX12P	466	Q92771
QGVIKLKNNGDFFIA	MCRS1	391	Q96EZ8
VDKIGQFQKIVGGLI	IFT20	41	Q8IY31
FIIFGILGVQLFKGK	CACNA1H	1441	O95180
KIKELQAFFGLQVTG	MMP20	71	O60882
EGAKFGLQQLVVAKI	SLC6A16	316	Q9GZN6
VFQVRKVQGTNLGKI	RPS6KB2	81	Q9UBS0
VKGVFLANQKIDGKV	SORCS2	451	Q96PQ0
QIDLGTGKIINFIKF	RPS4Y1	161	P22090
QKEGLKVFFRGITVN	SLC25A48	266	Q6ZT89
QKVGALIFLVVGIFF	SLC38A4	511	Q969I6
GILGNAILIKVFFKT	BRS3	61	P32247
AFIQFKKPIVVAING	CDYL2	341	Q8N8U2
KAIFIFISNTGGKQI	TOR2A	191	Q5JU69
TGVKGNVQGNLFKVI	PLEK2	311	Q9NYT0
KVVVFFTRNGKIIGK	SPRYD3	396	Q8NCJ5
FLFSVNGKIIEKIQG	NME8	86	Q8N427
KILGKINQFFVAVFT	SCN10A	1506	Q9Y5Y9
EQKVVTVGQFKIGLI	VPS29	71	Q9UBQ0
KTKFVGGIAQIIAAQ	TLN2	2491	Q9Y4G6
IVNIKIGVQVKFDGN	ZAN	2036	Q9Y493
LAVQKLVQKVGFFGI	VMP1	246	Q96GC9
VKAGFIGKVTLQIPF	VPS13D	56	Q5THJ4
KFIIKVLFIQKTGQA	DYNLT2	146	Q8IZS6