Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3 ATM

9.26e-0636316313GO:0106310
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF597 ZNF765 ZNF311 ZNF146 ZFP3 MYOD1 ZNF722 ISX ZNF772 ZNF619 SIM1 SIM2 ZNF835 ZNF17 ZNF713 ZNF497 ZNF792 ZNF41 PAX8 ZNF566 ZNF70 ZNF888 ZNF552 ZNF770 HSF2 ZNF649 ZNF697

5.11e-05145916327GO:0000977
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3 ATM

7.84e-0544616313GO:0004674
GeneOntologyMolecularFunctionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

CHSY1 CHSY3

3.93e-0441632GO:0050510
GeneOntologyMolecularFunctionprotein kinase activity

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 TEK MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3 ATM

4.18e-0460016314GO:0004672
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF597 ZNF765 ZNF311 ZNF146 ZFP3 MYOD1 ZNF722 ISX ZNF772 ZNF619 SIM1 SIM2 ZNF17 ZNF713 ZNF792 ZNF41 PAX8 ZNF566 ZNF70 ZNF888 ZNF552 ZNF770 HSF2 ZNF697

4.91e-04141216324GO:0000981
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

RASGRF1 RASGRF2 RIN1 SBF2 DOCK7 RAPGEF2 SMCR8 FGD6

6.35e-042311638GO:0005085
GeneOntologyMolecularFunctionferric-chelate reductase (NADPH) activity

STEAP2 STEAP1

6.52e-0451632GO:0052851
GeneOntologyMolecularFunctionferric-chelate reductase activity

STEAP2 STEAP1

6.52e-0451632GO:0000293
GeneOntologyMolecularFunctioncupric reductase (NADH) activity

STEAP2 STEAP1

6.52e-0451632GO:0008823
GeneOntologyMolecularFunctionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

CHSY1 CHSY3

9.72e-0461632GO:0047238
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

RPS6KA5 CLK4 RIPK2 TEK NEK1 CLK3

1.23e-031451636GO:0004713
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF597 ZNF765 ZNF311 ZNF146 ZFP3 MYOD1 ZNF722 ZNF772 ZNF835 ZNF17 ZNF713 ZNF497 ZNF792 ZNF41 PAX8 ZNF888 ZNF552 ZNF770 HSF2 ZNF649 ZNF697

1.24e-03124416321GO:0000978
GeneOntologyMolecularFunctionMutSalpha complex binding

MCM8 MLH1

1.35e-0371632GO:0032407
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions, NAD or NADP as acceptor

STEAP2 STEAP1

1.35e-0371632GO:0016723
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF597 ZNF765 ZNF311 ZNF146 ZFP3 MYOD1 ZNF722 ZNF772 ZNF835 ZNF17 ZNF713 ZNF497 ZNF792 ZNF41 PAX8 ZNF888 ZNF552 ZNF770 HSF2 ZNF649 ZNF697

1.61e-03127116321GO:0000987
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CDK17 RPS6KA5 CAMK2G SPEG CLK4 TUT7 RIPK2 PARP14 TEK MAP3K5 NUAK2 NEK1 CLK3 GYS1 STK33 MAPKAPK3 ATM

1.75e-0393816317GO:0016772
DomainZnf_C2H2/integrase_DNA-bd

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

1.33e-0969416125IPR013087
DomainZINC_FINGER_C2H2_1

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 TUT7 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

2.81e-0977716126PS00028
DomainZnf_C2H2

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 TUT7 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

5.85e-0980516126IPR007087
Domainzf-C2H2

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

6.35e-0969316124PF00096
DomainZINC_FINGER_C2H2_2

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

1.22e-0877516125PS50157
Domain-

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF697

2.05e-08679161233.30.160.60
DomainZnf_C2H2-like

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

2.07e-0879616125IPR015880
DomainZnF_C2H2

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF552 ZNF770 ZNF649 ZNF687 ZNF697

2.77e-0880816125SM00355
DomainKRAB

ZNF597 ZNF765 ZNF311 ZNF234 ZNF214 ZNF772 ZNF230 ZNF235 ZNF17 ZNF713 ZNF792 ZNF41 ZNF566 ZNF552 ZNF649

5.08e-0735816115PS50805
DomainKRAB

ZNF597 ZNF765 ZNF311 ZNF234 ZNF214 ZNF772 ZNF230 ZNF235 ZNF17 ZNF713 ZNF792 ZNF41 ZNF566 ZNF552 ZNF649

5.08e-0735816115PF01352
DomainKRAB

ZNF597 ZNF765 ZNF311 ZNF234 ZNF214 ZNF772 ZNF230 ZNF235 ZNF17 ZNF713 ZNF792 ZNF41 ZNF566 ZNF552 ZNF649

7.44e-0736916115SM00349
DomainKRAB

ZNF597 ZNF765 ZNF311 ZNF234 ZNF214 ZNF772 ZNF230 ZNF235 ZNF17 ZNF713 ZNF792 ZNF41 ZNF566 ZNF552 ZNF649

7.69e-0737016115IPR001909
DomainS_TKc

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 TEK MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

1.45e-0535916113SM00220
Domainzf-C2H2_6

ZNF597 ZNF765 ZNF311 ZNF234 ZNF619 ZNF17 ZNF497 ZNF532 ZNF792 ZNF566 ZNF770 ZNF649

1.84e-0531416112PF13912
DomainKinase-like_dom

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 TEK MAP3K5 NUAK2 NEK1 PTPN13 DST CLK3 STK33 MAPKAPK3 ATM

1.89e-0554216116IPR011009
DomainSer/Thr_kinase_AS

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

6.42e-0535716112IPR008271
DomainPROTEIN_KINASE_ST

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

7.33e-0536216112PS00108
DomainSIM_C

SIM1 SIM2

7.39e-0521612IPR010578
DomainSIM_C

SIM1 SIM2

7.39e-0521612PF06621
DomainSIM_C

SIM1 SIM2

7.39e-0521612PS51302
DomainProtein_kinase_ATP_BS

CDK17 RPS6KA5 CAMK2G SPEG CLK4 TEK MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

1.13e-0437916112IPR017441
DomainPkinase

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

1.19e-0438116112PF00069
DomainPROTEIN_KINASE_ATP

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 TEK MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

1.77e-0445916113PS00107
DomainVPS13

VPS13C VPS13D

2.20e-0431612IPR026847
DomainVPS13_mid_rpt

VPS13C VPS13D

2.20e-0431612PF16910
DomainVPS13

VPS13C VPS13D

2.20e-0431612PF16908
DomainVPS13_N2

VPS13C VPS13D

2.20e-0431612IPR031646
DomainVPS13_mid_rpt

VPS13C VPS13D

2.20e-0431612IPR031642
DomainProt_kinase_dom

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 TEK MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

3.27e-0448916113IPR000719
DomainPROTEIN_KINASE_DOM

CDK17 RPS6KA5 CAMK2G SPEG CLK4 RIPK2 TEK MAP3K5 NUAK2 NEK1 CLK3 STK33 MAPKAPK3

3.54e-0449316113PS50011
DomainSHR-BD

VPS13C VPS13D

4.38e-0441612IPR009543
DomainVPS13_C

VPS13C VPS13D

4.38e-0441612PF16909
DomainVPS13_C

VPS13C VPS13D

4.38e-0441612IPR031645
DomainSHR-BD

VPS13C VPS13D

4.38e-0441612PF06650
DomainRasGEFN

RASGRF1 RASGRF2 RAPGEF2

6.43e-04201613SM00229
DomainRasGEF_N

RASGRF1 RASGRF2 RAPGEF2

7.46e-04211613PF00618
DomainRas-like_Gua-exchang_fac_N

RASGRF1 RASGRF2 RAPGEF2

8.58e-04221613IPR000651
DomainRASGEF_NTER

RASGRF1 RASGRF2 RAPGEF2

8.58e-04221613PS50212
Domain-

CUBN CDCP1 MEGF8 SEZ6

1.04e-035216142.60.120.290
DomainCUB

CUBN CDCP1 MEGF8 SEZ6

1.12e-03531614PS01180
DomainCUB_dom

CUBN CDCP1 MEGF8 SEZ6

1.47e-03571614IPR000859
DomainTUDOR

TDRD9 ARID4A RNF17

1.58e-03271613SM00333
DomainCYCLINS

CCNT1 CCNE2 CCNI

1.76e-03281613PS00292
DomainRASGEF_CAT

RASGRF1 RASGRF2 RAPGEF2

1.95e-03291613PS50009
DomainChond_GalNAc

CHSY1 CHSY3

2.00e-0381612IPR008428
DomainChorein_N

VPS13C VPS13D

2.00e-0381612PF12624
DomainCHGN

CHSY1 CHSY3

2.00e-0381612PF05679
DomainVPS13_N

VPS13C VPS13D

2.00e-0381612IPR026854
DomainRasGEF

RASGRF1 RASGRF2 RAPGEF2

2.15e-03301613PF00617
Domain-

RASGRF1 RASGRF2 RAPGEF2

2.15e-033016131.10.840.10
DomainRASGEF_cat_dom

RASGRF1 RASGRF2 RAPGEF2

2.15e-03301613IPR001895
DomainTudor

TDRD9 ARID4A RNF17

2.15e-03301613IPR002999
DomainRasGEF

RASGRF1 RASGRF2 RAPGEF2

2.15e-03301613SM00147
DomainRas_GEF_dom

RASGRF1 RASGRF2 RAPGEF2

2.15e-03301613IPR023578
Domainzf-C2H2_11

ZNF532 ZNF687

2.55e-0391612PF16622
DomainCyclin_N

CCNT1 CCNE2 CCNI

2.84e-03331613PF00134
DomainCyclin_N

CCNT1 CCNE2 CCNI

2.84e-03331613IPR006671
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF597 GAD1 ZNF311 THOC7 ZNF234 CAMK2G TSC1 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 CCNT1 ZNF17 ZNF713 PSME4 ZNF792 ZNF41 CCNE2 ZNF566 MLH1 ZNF70 ZNF552 ZNF770 ATM ZNF649 CDC27 MED13 ZNF697

2.59e-06138711829M734
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RALGAPA1 USP53 VPS13C HECTD4 CHSY1 ERI2 NUAK2 KANSL3 DST PSME4 USP38 ZNF532 NBEAL2 SENP6 MED13 ZNF687

6.63e-095291671614621295
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

RALGAPA1 USP53 CDK17 ZNF146 CALU RIPK2 LUZP1 NUAK2 NEK1 VPS13D PTPN13 DST MEGF8 AASS CLK3 DOCK7 RAPGEF2 FGD6 SAMD4A ARHGAP19

7.05e-098611672036931259
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PNPLA2 ITPRIPL2 ATP13A1 SPEG HECTD4 CHSY1 SIAH2 PLXNB2 MAP3K5 KANSL3 BMP4 DST PSME4 MEGF8 SH3TC1 ADAMTS7 INF2 PLA2G4B NBEAL2 SBF2 MED13 ZNF687

1.89e-0811051672235748872
Pubmed

A GO catalogue of human DNA-binding transcription factors.

ZNF234 ZNF214 ZNF230 ZNF235 ZNF532 ZNF687

5.09e-0842167634673265
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF311 ZNF235 ZNF17 ZNF792 ZNF41 ZNF566 ZNF552 ZNF649 ZNF697

2.53e-07181167937372979
Pubmed

Sim1 and Sim2 expression during chick and mouse limb development.

MYOD1 SIM1 SIM2

4.33e-074167319123137
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RALGAPA1 USP53 CACNA1C DPP6 MCM8 VPS45 VPS13C HECTD4 STEAP2 KANSL3 CNNM4 PPP2R3A PTPN13 SH3TC1 ZNF532 INF2 MICAL2 GLYR1 SBF2 LMLN SEL1L3 RAPGEF2 STEAP1

8.06e-0714891672328611215
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

RALGAPA1 CENPF DHX40 CCNT1 DST AASS CLK3 MARF1

5.39e-06197167820811636
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CDK17 ZNF146 VPS45 ZYG11B LUZP1 CNNM4 RIN1 NEK1 PTPN13 LMAN1 WDCP GYS1 MARF1 DOCK7 AIPL1 SPAG16 CDC27 FGD6 STEAP1 ARHGAP19

6.03e-0613211672027173435
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

CENPF CAMK2G LUZP1 NEK1 PTPN13 DST LMAN1 ZNF532 WDCP DOCK7 ZNF687

6.26e-064181671134709266
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

RPS6KA5 CAMK2G CLK4 RIPK2 LUZP1 NUAK2 CCNT1 NEK1 DST CLK3 CCNE2 STK33 CPLANE1 CDC27 CCNI ZNF687

8.91e-069101671636736316
Pubmed

RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.

RASGRF1 RASGRF2

2.29e-052167226743081
Pubmed

Metabotropic glutamate receptors drive global persistent inhibition in the visual thalamus.

GAD1 GRM5

2.29e-052167223392677
Pubmed

Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

RASGRF1 RASGRF2

2.29e-052167216467520
Pubmed

Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

SIM1 SIM2

2.29e-05216729199934
Pubmed

Single-minded--two genes, three chromosomes.

SIM1 SIM2

2.29e-05216729199929
Pubmed

The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.

RASGRF1 RASGRF2

2.29e-052167217141611
Pubmed

Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.

SIM1 SIM2

2.29e-052167210837894
Pubmed

Mutation screening of BMP4 and Id2 genes in Chinese patients with congenital ureteropelvic junction obstruction.

ID2 BMP4

2.29e-052167221927809
Pubmed

Chondroitin sulfate synthase-3. Molecular cloning and characterization.

CHSY1 CHSY3

2.29e-052167212907687
Pubmed

Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.

MLH1 ATM

2.29e-052167220709753
Pubmed

Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.

RASGRF1 RASGRF2

2.29e-052167219193896
Pubmed

Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.

RASGRF1 RASGRF2

2.29e-052167214749369
Pubmed

BMP4 regulates pancreatic progenitor cell expansion through Id2.

ID2 BMP4

2.29e-052167216547003
Pubmed

Genome-wide homozygosity mapping in families with leber congenital amaurosis identifies mutations in AIPL1 and RDH12 genes.

RDH12 AIPL1

2.29e-052167225148430
Pubmed

A murine CDC25/ras-GRF-related protein implicated in Ras regulation.

RASGRF1 RASGRF2

2.29e-05216728293576
Pubmed

Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.

RASGRF1 RASGRF2

2.29e-052167228966131
Pubmed

A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.

SIM1 SIM2

2.29e-052167214697214
Pubmed

The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.

RASGRF1 RASGRF2

2.29e-052167231182637
Pubmed

Metabotropic glutamate receptor type 5-dependent long-term potentiation of excitatory synapses on fast-spiking GABAergic neurons in mouse visual cortex.

GAD1 GRM5

2.29e-052167218234900
Pubmed

Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals.

MYOD1 BMP4

2.29e-052167217569791
Pubmed

DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma.

MLH1 DLEC1

2.29e-052167218594535
Pubmed

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes.

RIPK2 MAP3K5

2.29e-052167234759307
Pubmed

A two-hybrid assay to study protein interactions within the secretory pathway.

MYOD1 ID2

2.29e-052167221209940
Pubmed

Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication.

MYOD1 SIM1 BMP4

3.00e-0513167311455436
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CACNA1C RASGRF2 CENPF SPEG ABHD10 RIPK2 TSC1 VPS13D NBEAL2 ATM ZNF687

3.10e-054971671136774506
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

RALGAPA1 VPS45 VPS13C TSC1 VPS13D PTPN13 DST LMAN1 MEGF8 INF2 SMCR8

3.52e-055041671134432599
Pubmed

Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

RASGRF1 RASGRF2 CAMK2G

3.81e-0514167310373510
Pubmed

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

RASGRF1 RASGRF2 CAMK2G

4.74e-0515167314622581
Pubmed

Defining the membrane proteome of NK cells.

MYO1C ATP13A1 CALU CAMK2G CHSY1 PARP14 ADAM10 LUZP1 LMAN1 CLK3 NBEAL2 GYS1 MARF1 MLH1 HECA MED13 STEAP1

5.11e-0511681671719946888
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

RALGAPA1 CDK17 LUZP1 PTPN13 DST DOCK7 CEP295 RAPGEF2 SAMD4A XPR1

6.42e-054461671024255178
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

CCNT1 RNF123 SBF2 DOCK7 MLH1

6.46e-0587167517148452
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MXRA5 CALU DHX40 CAMK2G RNF123 MEGF8 AASS GYS1 NFKBIB CEP295 SMCR8 ZNF687

6.51e-056381671231182584
Pubmed

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.

RASGRF1 RASGRF2

6.85e-053167221685891
Pubmed

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

CHSY1 CHSY3

6.85e-053167233089528
Pubmed

Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.

RASGRF1 RASGRF2

6.85e-053167211909944
Pubmed

Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome.

SIM1 SIM2

6.85e-05316727485157
Pubmed

cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.

SIM1 SIM2

6.85e-05316728561800
Pubmed

The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.

STEAP2 STEAP1

6.85e-053167232802887
Pubmed

Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.

RASGRF1 ATM

6.85e-053167217611684
Pubmed

Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.

RASGRF1 RASGRF2

6.85e-053167215029245
Pubmed

BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling.

ID2 BMP4

6.85e-053167228543546
Pubmed

Small suitability of the DLEC1, MLH1 and TUSC4 mRNA expression analysis as potential prognostic or differentiating markers for NSCLC patients in the Polish population.

MLH1 DLEC1

6.85e-053167228674222
Pubmed

Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.

STEAP2 STEAP1

6.85e-053167212095985
Pubmed

Primary Congenital Glaucoma

TEK LTBP2

6.85e-053167220301314
Pubmed

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

SIM1 SIM2

6.85e-053167224814368
Pubmed

Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.

MLH1 ATM

6.85e-053167216150740
Pubmed

Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers.

MLH1 ATM

6.85e-053167227693945
Pubmed

ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.

SIM2 ATM

6.85e-053167230531838
Pubmed

Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, in non-small cell lung cancer.

MLH1 DLEC1

6.85e-053167227287342
Pubmed

Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.

STEAP2 STEAP1

6.85e-053167219196137
Pubmed

Characterization of msim, a murine homologue of the Drosophila sim transcription factor.

SIM1 SIM2

6.85e-05316728661115
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

CENPF ZNF230 ZNF17 DST CEP295 CCNI

9.39e-05151167617043677
Pubmed

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.

MYOD1 SIM1 BMP4

9.96e-051916739585504
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

USP53 VPS13C SPEG KANSL3 FGD6 ZNF687

1.01e-04153167610718198
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF234 ZNF230 ZNF235

1.17e-0420167312743021
Pubmed

Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.

ID2 PAX8

1.37e-044167211134340
Pubmed

Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.

RPS6KA5 CAMK2G

1.37e-044167214963018
Pubmed

Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors.

RASGRF1 RASGRF2

1.37e-044167219692568
Pubmed

Cardiotrophin-1 stimulates lipolysis through the regulation of main adipose tissue lipases.

PNPLA2 CTF1

1.37e-044167225351614
Pubmed

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

ADAM10 CTF1

1.37e-044167215958533
Pubmed

An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.

TSC1 PAX8

1.37e-044167236357396
Pubmed

Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress.

HSF2 CDC27

1.37e-044167220937767
Pubmed

RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras.

RASGRF1 RASGRF2

1.37e-044167227856453
Pubmed

Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.

CHSY1 CHSY3

1.37e-044167221468578
Pubmed

P-TEFb is degraded by Siah1/2 in quiescent cells.

SIAH2 CCNT1

1.37e-044167235524561
Pubmed

ATM controls meiotic double-strand-break formation.

MLH1 ATM

1.37e-044167222002603
Pubmed

Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.

RASGRF1 RASGRF2

1.37e-044167223145787
Pubmed

Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase.

RPS6KA5 MAPKAPK3

1.37e-044167211335727
Pubmed

Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression.

MYOD1 ID2

1.37e-044167210915743
Pubmed

Analysis of the human VPS13 gene family.

VPS13C VPS13D

1.37e-044167215498460
Pubmed

Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS.

SIM1 SIM2

1.37e-044167211023872
Pubmed

The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.

MYOD1 ID2

1.37e-044167211940648
Pubmed

Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal.

MYOD1 ID2

1.37e-04416728576241
Pubmed

Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.

SENP6 HSF2

1.37e-044167211278381
Pubmed

Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.

CLK4 CLK3

1.37e-04416729307018
Pubmed

Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.

STEAP2 STEAP1

1.37e-044167234649092
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TUT7 ZYG11B SBF2 DOCK7 CEP295

1.38e-04102167511214970
Pubmed

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

USP53 USP44 USP38

1.79e-0423167314715245
Pubmed

Human transcription factor protein interaction networks.

THOC7 REXO4 ZNF146 MYO1C ARID4A CALU MYOD1 DHX40 ISX KANSL3 DST PAX8 WDCP GLYR1 NFKBIB MARF1 ZNF770 ZNF687

1.89e-0414291671835140242
Pubmed

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.

ID2 BMP4 PPP2R3A DST LTBP2 ATM

2.23e-04177167622560297
Pubmed

BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling.

TEK BMP4

2.27e-045167218006519
Pubmed

Role of p38alpha Map kinase in Type I interferon signaling.

RPS6KA5 MAPKAPK3

2.27e-045167214578350
Pubmed

The Steap proteins are metalloreductases.

STEAP2 STEAP1

2.27e-045167216609065
Pubmed

ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage.

MLH1 ATM

2.27e-045167215226443
Pubmed

Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells.

MLH1 ATM

2.27e-045167221355037
Pubmed

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

BMP4 DOCK7

2.27e-045167222158624
Pubmed

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

USP44 CDC27

2.27e-045167217443180
Pubmed

Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.

STEAP2 STEAP1

2.27e-045167212429817
Pubmed

OUT, a novel basic helix-loop-helix transcription factor with an Id-like inhibitory activity.

MYOD1 ID2

2.27e-045167210652346
InteractionYWHAB interactions

RALGAPA1 CDK17 ZNF146 RASGRF1 CAMK2G SPEG HECTD4 RIPK2 TSC1 LUZP1 MAP3K5 RIN1 NEK1 VPS13D LRFN4 PTPN13 DST AASS CLK3 DOCK7 RAPGEF2 FGD6 SAMD4A ARHGAP19

2.21e-06101416324int:YWHAB
InteractionYWHAH interactions

RALGAPA1 USP53 CDK17 ZNF146 CAMK2G SPEG HECTD4 RIPK2 TSC1 LUZP1 MAP3K5 NUAK2 RIN1 NEK1 VPS13D PTPN13 DST MEGF8 AASS CLK3 DOCK7 RAPGEF2 FGD6 SAMD4A ARHGAP19

2.82e-06110216325int:YWHAH
InteractionYWHAZ interactions

RALGAPA1 CDK17 ZNF146 RASGRF1 RPS6KA5 RASGRF2 CAMK2G SPEG HECTD4 TSC1 LUZP1 MAP3K5 NUAK2 RIN1 NEK1 VPS13D PTPN13 DST AASS CLK3 NBEAL2 DOCK7 ATM RAPGEF2 FGD6 SAMD4A ARHGAP19

7.30e-06131916327int:YWHAZ
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF765 ZNF146 ZNF234 ZNF772 ZNF230 ZNF235 ZNF835 ZNF17 ZNF497 MEGF8 ZNF792 GYS1 NFKBIB ZNF566 ZNF888 ZNF552 ZNF649 ASPDH

4.11e-07119216718chr19q13
Cytoband19q13.43

ZNF772 ZNF835 ZNF497 ZNF552

2.97e-0487167419q13.43
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF597 ZNF765 ZNF311 ZNF146 ZNF234 ZFP3 ZNF214 ZNF772 ZNF619 ZNF230 ZNF235 ZNF835 ZNF17 ZNF713 ZNF497 ZNF532 ZNF792 ZNF41 ZNF566 ZNF70 ZNF888 ZNF552 ZNF770 ZNF649 ZNF697

8.93e-127181212528
GeneFamilyCDC like kinases

CLK4 CLK3

2.64e-0441212480
GeneFamilyProteases, serine|STEAP family

STEAP2 STEAP1

4.38e-04512121324
GeneFamilyCyclins

CCNT1 CCNE2 CCNI

8.48e-04281213473
GeneFamilyMitogen-activated protein kinase-activated protein kinases

RPS6KA5 MAPKAPK3

2.35e-031112121156
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 CUBN PPP2R3A PTPN13 PAX8 GLDC STK33 ATP6V0A4 CACNA2D3

4.83e-08193166982e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 SIM2 PPP2R3A PTPN13 PAX8 STK33 ATP6V0A4 SPAG16 CACNA2D3

5.05e-08194166993c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 PPP2R3A PTPN13 PAX8 GLDC STK33 ATP6V0A4 SPAG16 CACNA2D3

5.05e-0819416695eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 SIM2 PPP2R3A PTPN13 PAX8 STK33 ATP6V0A4 SPAG16 CACNA2D3

5.52e-0819616696ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ZNF146 ARID4A LUZP1 VPS13D ZNF41 MARF1 ZNF770 CEP295

5.07e-07186166803db813598b67b1e08f759758a1c2023396921fa
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPP6 SIM1 CUBN PPP2R3A PAX8 GLDC ATP6V0A4 CACNA2D3

5.28e-071871668d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SIM1 FREM1 PPP2R3A PTPN13 PAX8 GLDC ATP6V0A4 SPAG16

5.49e-0718816688f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6|TCGA-Stomach / Sample_Type by Project: Shred V9

RIPK2 PARP14 STEAP2 CDCP1 PLXNB2 ADAM10 RIN1 STEAP1

6.44e-0719216684e689bca7a242f8482e25f273656e2caba8821c0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 CUBN PPP2R3A PTPN13 PAX8 GLDC STK33 ATP6V0A4

6.70e-0719316683866667dd221612589ae50f5c52f73a183a49ce6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 SIM2 PPP2R3A PTPN13 PAX8 STK33 SPAG16 CACNA2D3

7.24e-0719516686477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 SIM2 PPP2R3A PTPN13 PAX8 STK33 ATP6V0A4 CACNA2D3

7.53e-071961668eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Mesenchymal-Mesoderm|GW13 / Sample Type, Dataset, Time_group, and Cell type.

DPP6 RASGRF2 RIPK2 ZNF214 ERI2 SMYD4 PTPN13 SEL1L3

8.76e-0720016680f4b8b0868bda406fe6bf01d1b722510fdfd0168
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1C TNFAIP8L2 PNPLA2 MAP3K5 SH3TC1 RAPGEF2 HECA

3.99e-06173166720f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MXRA5 FREM1 PTPN13 PAX8 GLDC STK33 DOCK7

5.57e-061821667f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRF2 ERI2 TEK KANSL3 PTPN13 SLC9A5 LRRD1

6.20e-061851667bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 PPP2R3A PAX8 STK33 SPAG16 CACNA2D3 SAMD4A

6.89e-061881667af740fa78542438fdff627ea1f74f4eee43316be
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

CACNA1C PPP2R3A DST STK33 CACNA2D3 SAMD4A XPR1

7.38e-061901667fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 FREM1 PTPN13 PAX8 NBEAL2 STK33 ATP6V0A4

7.64e-0619116673e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

GAD1 SIM1 SIM2 PPP2R3A PAX8 ATP6V0A4 CACNA2D3

7.64e-061911667fe55475ce0666ab5122447a813dc2369e24947b8
ToppCellCOVID-19-kidney-CNT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SIM1 FREM1 PPP2R3A PTPN13 PAX8 GLDC ATP6V0A4

7.90e-061921667760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

RALGAPA1 USP38 SBF2 ZNF770 CPLANE1 SMCR8 MED13

8.18e-061931667abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 CDCP1 PPP2R3A PAX8 GLDC CACNA2D3 SAMD4A

8.18e-061931667f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 CDCP1 PPP2R3A PAX8 GLDC CACNA2D3 SAMD4A

8.18e-06193166742df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MXRA5 FREM1 PTPN13 PAX8 NBEAL2 STK33 ATP6V0A4

8.46e-06194166704bfc555743f7d8821439d05ae442d15e9886c59
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MXRA5 FREM1 PTPN13 PAX8 NBEAL2 STK33 ATP6V0A4

8.46e-06194166769bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SQLE PLXNB2 SMYD4 PTPN13 LMAN1 PLA2G4B ATP6V0A4

9.35e-0619716671485933986921ff45669d9b7501c8d17050b3e97
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast|ICU-NoSEP / Disease, condition lineage and cell class

CALU NEK1 LMAN1 GLDC STK33 SEL1L3 STEAP1

9.35e-0619716678f35f9741086a38f0e594dce0547b575946f52bb
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SQLE CDCP1 PLXNB2 USP44 SMYD4 PTPN13 LMAN1

9.66e-061981667285f729140b1df029c24f6ca1d2438470ac51794
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C MXRA5 FREM1 BMP4 CHSY3 LTBP2 CACNA2D3

1.03e-05200166758b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellASK454-Epithelial-Type_2|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CDK17 CENPF MEGF8 ZNF41 LMLN SPAG16

1.22e-051361666ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCellPBMC-Severe-cDC_3|Severe / Compartment, Disease Groups and Clusters

ITPRIPL2 ZNF835 USP44 STK33 PWP2 CTF1

2.29e-0515216661a3f8ed476aa9a39742b4684be2c704669e4a3d0
ToppCell10x5'-blood-Lymphocytic_T_CD4-Trm_Th1/Th17|blood / Manually curated celltypes from each tissue

COG7 SIAH2 ZNF619 PTPN13 ZNF888 SAMD4A

2.75e-051571666c99cb26d831c25038f2aa1b1c0f7ba52facb2e7a
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TDRD9 CYSLTR1 ID2 IDI2 PTPN13 MAPKAPK3

3.39e-051631666476e94e1d132eaaecb9e376bd32748a75ad22081
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ZFP3 AMACR HECTD4 SMPDL3A LTBP2 SAMD4A

3.51e-051641666d7053de88ef8e42cac6726a40e72f212659ee034
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF235 PARP14 TEK RIN1 ZNF770 TOR1B

3.88e-051671666774f3264318b002d0df5d06d41d645366038d0bf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF234 CUBN KANSL3 NEK1 STK33 LMLN

4.01e-051681666ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1C GAD1 VPS13C CDCP1 LRFN4 USP38

4.88e-051741666f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|368C / Donor, Lineage, Cell class and subclass (all cells)

REXO4 MCM8 CNNM4 ZNF17 CCNE2 WDCP

5.71e-051791666ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MXRA5 FREM1 PTPN13 GLDC STK33 DOCK7

5.89e-051801666788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 SIM1 FREM1 GLDC ATP6V0A4 CACNA2D3

6.26e-0518216665f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SIM1 CUBN PPP2R3A PAX8 GLDC CACNA2D3

6.26e-0518216669d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCelldroplet-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ID2 CUBN STEAP2 PSME4 GLDC ATP6V0A4

6.65e-051841666e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

ZNF597 CMKLR2 SIAH2 ZNF619 GRM5

6.83e-051141665656072c25258d4c00f24f6ba17de6a5db891e7be
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PNPLA2 RPS6KA5 CNNM4 CCNT1 BMP4 DST

6.86e-05185166687151ab95530e70d61328b336518df58db584acb
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PTPN13 PAX8 GLDC STK33 DOCK7 SPAG16

6.86e-051851666d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C CDK17 SPEG MICAL2 LTBP2 SAMD4A

6.86e-051851666e58a009aaf342be019a909747b1895d5987d4daf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 FREM1 PPP2R3A PTPN13 GLDC ATP6V0A4

7.06e-05186166608632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DPP6 SIM2 PPP2R3A PAX8 SPAG16 CACNA2D3

7.28e-051871666c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 GAD1 SIM2 ATP6V0A4 LTBP2 CACNA2D3

7.28e-0518716667ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SIM1 SIM2 NUAK2 PAX8 SEL1L3 CACNA2D3

7.28e-051871666c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FREM1 PAX8 GLDC STK33 ATP6V0A4 DOCK7

7.28e-0518716662d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RALGAPA1 CDK17 VPS13C PARP14 RAPGEF2 MED13

7.49e-051881666ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

GAD1 SIM1 PPP2R3A PAX8 ATP6V0A4 CACNA2D3

7.49e-0518816661d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 GAD1 SIM1 SIM2 ATP6V0A4 CACNA2D3

7.72e-051891666f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FREM1 SH3TC1 GLDC STK33 ATP6V0A4 DOCK7

7.72e-051891666532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 ADAM10 PPP2R3A PAX8 SEL1L3 CACNA2D3

8.18e-051911666d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 NUAK2 PPP2R3A PAX8 CACNA2D3 SAMD4A

8.18e-0519116669032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellCOVID-19-kidney-Mito-rich_Distal|COVID-19 / Disease (COVID-19 only), tissue and cell type

SIM1 SIM2 PPP2R3A PAX8 ATP6V0A4 CACNA2D3

8.18e-0519116660965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 NUAK2 PPP2R3A PAX8 CACNA2D3 SAMD4A

8.18e-0519116665717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 CACNA1C STEAP2 FREM1 DST LTBP2

8.18e-0519116666688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellCOVID-19-kidney-CNT|kidney / Disease (COVID-19 only), tissue and cell type

MXRA5 CHSY1 SIM1 FREM1 PPP2R3A PTPN13

8.41e-051921666d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

GAD1 SIM1 SIM2 ATP6V0A4 LTBP2 CACNA2D3

8.41e-051921666562df5e87038c500dd3a003fe5374cb31946b145
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CDK17 CHSY1 SH3TC1 MICAL2 SEL1L3 SAMD4A

8.41e-0519216668b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 CDCP1 DST PAX8 CACNA2D3 SAMD4A

9.16e-051951666938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIM2 CDCP1 DST PAX8 CACNA2D3 SAMD4A

9.16e-051951666d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

USP53 CACNA1C STEAP2 FREM1 DST AASS

9.42e-051961666bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CENPF VPS13C VPS13D PTPN13 LMLN CDC27

9.96e-05198166676d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellEpithelial_cells-AT1-AT2_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

MYO1C ARID4A DST INF2 NBEAL2 SAMD4A

9.96e-051981666fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 CACNA1C STEAP2 DST AASS LTBP2

9.96e-051981666f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

USP53 CACNA1C STEAP2 DST AASS LTBP2

1.02e-04199166666a79732caf2f04c09b4d9832377aa01ca477677
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1C STEAP2 FREM1 DST LTBP2 SAMD4A

1.05e-042001666389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell(5)_Fibroblasts|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MXRA5 ARID4A STEAP2 DST LTBP2 STEAP1

1.05e-04200166622c839f27d3abdf86bfabdfa305f205dd899a9dc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial|10w / Sample Type, Dataset, Time_group, and Cell type.

ITPRIPL2 SIM1 SIM2 RIN1 LTBP2 SMCR8

1.05e-042001666ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

USP53 CACNA1C STEAP2 DST AASS LTBP2

1.05e-042001666aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

USP53 CACNA1C STEAP2 DST AASS LTBP2

1.05e-042001666a510deaada669e690329183e18df02870bd204b3
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell|10w / Sample Type, Dataset, Time_group, and Cell type.

ITPRIPL2 SIM1 SIM2 RIN1 LTBP2 SMCR8

1.05e-04200166607d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP53 CACNA1C STEAP2 FREM1 DST LTBP2

1.05e-042001666311fab076f2ceb258e3970eb21e39344b894042a
ToppCellFibroblast|World / shred by cell class for parenchyma

MXRA5 ARID4A STEAP2 DST LTBP2 STEAP1

1.05e-042001666dec9ce1bc2571197003596f32e5f742ede72aa79
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

USP53 CACNA1C STEAP2 FREM1 DST LTBP2

1.05e-04200166634f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

USP53 CACNA1C STEAP2 DST AASS LTBP2

1.05e-042001666dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell(01)_Cycling_Basal_(homeostasis)-(3)_72hpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

VPS13C USP44 SAMD4A

1.51e-04281663ef8053df22b28c772eb39c5e4033f96eb5aa54d9
DrugPrednisolone [50-24-8]; Up 200; 11uM; PC3; HT_HG-U133A

KANSL3 CNNM4 BMP4 SLC9A5 SH3TC1 PAX8 MICAL2 NFKBIB CPLANE1 SAMD4A

1.30e-06192163105101_UP
DrugOxethazaine [126-27-2]; Up 200; 8.6uM; PC3; HG-U133A

ATP13A1 SQLE PLXNB2 MAP3K5 CNNM4 RNF123 LRFN4 SEL1L3 CDC27 ARHGAP19

1.49e-06195163101903_UP
Drugsemustine; Down 200; 100uM; PC3; HT_HG-U133A

RALGAPA1 CDK17 ZNF235 ADAM10 NUAK2 NEK1 CCNE2 SENP6 FGD6

1.14e-0519416397545_DN
DrugSTOCK1N-35874; Down 200; 14uM; PC3; HT_HG-U133A

RALGAPA1 GAD1 RPS6KA5 ZNF230 PPP2R3A INF2 MARF1 ZNF552 SPAG16

1.29e-0519716396561_DN
DrugTenoxicam [59804-37-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A

RALGAPA1 CENPF ZNF230 SH3TC1 ATP6V0A4 NFKBIB ZNF552 LTBP2 RAPGEF2

1.29e-0519716392860_UP
DrugHalcinonide [3093-35-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A

GAD1 LUZP1 RIN1 VPS13D PSME4 WDCP NFKBIB ZNF552 ATM

1.34e-0519816394703_DN
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A_EA

RALGAPA1 GAD1 RPS6KA5 CAMK2G ID2 KANSL3 GLYR1 NFKBIB HSF2

1.34e-0519816391002_UP
DrugBenzocaine [94-09-7]; Down 200; 24.2uM; MCF7; HT_HG-U133A

GAD1 CENPF RIN1 NEK1 VPS13D PPP2R3A PSME4 SENP6 LTBP2

1.34e-0519816394808_DN
Drugtyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA

CDK17 CLK4 SQLE CHSY1 CCNE2 RAPGEF2 MED13 SAMD4A

5.81e-0518516381114_DN
Drug0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A

TUT7 HECTD4 MAP3K5 VPS13D PPP2R3A MICAL2 CCNE2 ATM

5.81e-0518516384755_DN
Drug5182598; Down 200; 25uM; MCF7; HT_HG-U133A_EA

RPS6KA5 ABHD10 MAP3K5 NUAK2 BMP4 NEK1 PPP2R3A SMPDL3A

6.26e-051871638868_DN
DrugApigenin [520-36-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A

GAD1 RPS6KA5 MAP3K5 BMP4 PPP2R3A PSME4 SENP6 RAPGEF2

6.75e-0518916384401_DN
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A

SQLE MAP3K5 VPS13D PPP2R3A PSME4 CCNE2 SENP6 MED13

7.00e-0519016382619_DN
DrugLidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; PC3; HT_HG-U133A

CDK17 CALU SQLE ZNF230 MAP3K5 PPP2R3A LMAN1 CCNE2

7.81e-0519316384596_DN
DrugPiroxicam [36322-90-4]; Down 200; 12uM; HL60; HG-U133A

CDK17 COG7 VPS13C ADAM10 LUZP1 VPS13D LMAN1 CLK3

8.10e-0519416381405_DN
DrugFlutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A

SQLE SIM2 NEK1 PPP2R3A PSME4 GLYR1 NFKBIB CDC27

8.10e-0519416384361_DN
DrugCP-690334-01 [459212-38-5]; Down 200; 1uM; MCF7; HT_HG-U133A

CDK17 CAMK2G ADAM10 LUZP1 VPS13D LMAN1 GLYR1 NFKBIB

8.40e-0519516383909_DN
DrugDipyrone [5907-38-0]; Down 200; 12uM; MCF7; HT_HG-U133A

MAP3K5 NEK1 LMAN1 SH3TC1 GLYR1 ATP6V0A4 NFKBIB RAPGEF2

8.40e-0519516383835_DN
DrugPiperine [94-62-2]; Down 200; 14uM; HL60; HT_HG-U133A

PNPLA2 ADAM10 LMAN1 INF2 PAX8 CCNE2 ZNF552 HSF2

8.70e-0519616381327_DN
DrugIfenprodil tartrate [23210-58-4]; Down 200; 8.4uM; HL60; HT_HG-U133A

SQLE NUAK2 LRFN4 LMAN1 MEGF8 INF2 ZNF552 LTBP2

8.70e-0519616382372_DN
DrugCefoxitin sodium salt [33564-30-6]; Up 200; 8.8uM; PC3; HT_HG-U133A

CDK17 NUAK2 RIN1 INF2 AASS GLYR1 CPLANE1 HSF2

9.01e-0519716387148_UP
DrugTenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CAMK2G NEK1 PPP2R3A LRFN4 LMAN1 INF2 SMPDL3A SENP6

9.01e-0519716382860_DN
DrugDihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A

CMKLR2 MXRA5 CENPF SPEG CDCP1 TEK SH3TC1 PAX8

9.01e-0519716384152_UP
DrugBepridil hydrochloride [74764-40-2]; Down 200; 10uM; PC3; HT_HG-U133A

CAMK2G SQLE NEK1 PTPN13 LMAN1 INF2 CCNE2 NFKBIB

9.01e-0519716384613_DN
DrugSulfamethoxazole [723-46-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A

RALGAPA1 GAD1 MYO1C CAMK2G SPEG VPS13D MEGF8 ATM

9.01e-0519716384690_UP
DrugAscorbic acid [50-81-7]; Down 200; 22.4uM; MCF7; HT_HG-U133A

PNPLA2 LUZP1 BMP4 NEK1 NBEAL2 NFKBIB AIPL1 ZNF552

9.01e-0519716383225_DN
DrugThalidomide [50-35-1]; Down 200; 15.4uM; PC3; HT_HG-U133A

CALU SQLE CCNT1 NEK1 PPP2R3A LMAN1 PSME4 NBEAL2

9.01e-0519716382095_DN
DrugFluorometholone [426-13-1]; Down 200; 10.6uM; PC3; HT_HG-U133A

CDK17 CENPF COG7 ID2 NEK1 LMAN1 ATM HSF2

9.01e-0519716385771_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

CMKLR2 SPEG LUZP1 CCNT1 BMP4 SENP6 SPAG16 HSF2

9.34e-0519816381237_DN
Drugtroglitazone; Down 200; 10uM; MCF7; HT_HG-U133A_EA

CCNT1 VPS13D PPP2R3A PSME4 INF2 MAPKAPK3 ATM SAMD4A

9.34e-0519816381070_DN
DrugOxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; MCF7; HT_HG-U133A

MXRA5 AMACR VPS13C ZNF235 PPP2R3A ADAMTS7 LTBP2 CPLANE1

9.34e-0519816383170_UP
DrugPrazosin hydrochloride [19237-84-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

GAD1 CENPF RNF17 LUZP1 LMAN1 AASS GLYR1 ATP6V0A4

9.34e-0519816385416_UP
DrugNifurtimox [23256-30-6]; Down 200; 14uM; MCF7; HT_HG-U133A

CENPF SIM2 MAP3K5 NUAK2 CLK3 GLYR1 SENP6 ATM

9.34e-0519816387328_DN
Diseaseautosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)

VPS13C VPS13D

8.30e-0531562DOID:0111611 (implicated_via_orthology)
DiseaseGLAUCOMA 3, PRIMARY INFANTILE, B

TEK LTBP2

8.30e-0531562600975
DiseaseGLAUCOMA 3, PRIMARY INFANTILE, B

TEK LTBP2

8.30e-0531562C1832977
DiseaseGlaucoma 3, primary infantile, B

TEK LTBP2

8.30e-0531562cv:C1832977
DiseaseHydrophthalmos

TEK LTBP2

2.75e-0451562C0020302
DiseaseCiliopathies

RDH12 TSC1 NEK1 AIPL1 CPLANE1

3.03e-041101565C4277690
DiseasePolydactyly

CENPF BMP4 NEK1 MEGF8 CPLANE1

4.03e-041171565C0152427
Diseasemethylcobalamin deficiency type cblE, cytotoxicity measurement

AIPL1 CHSY3

4.11e-0461562EFO_0006952, MONDO_0009354
Diseaseatrioventricular septal defect (implicated_via_orthology)

BMP4 GLYR1

5.73e-0471562DOID:0050651 (implicated_via_orthology)
DiseaseUnilateral agenesis of kidney

FREM1 BMP4

7.62e-0481562C0266294
DiseaseDisorder of eye

RDH12 FREM1 CNNM4 BMP4 AIPL1 CPLANE1

9.52e-042121566C0015397
Diseaseacoustic startle blink response measurement

CACNA1C PARP14

9.76e-0491562EFO_0006875
Diseasenitric oxide exhalation measurement

CACNA1C DLEC1 CACNA2D3

1.07e-03381563EFO_0005536
Diseaseresponse to antihypertensive drug

DPP6 HECTD4 RAPGEF2

1.33e-03411563EFO_0005405
Diseaseresponse to statin, myopathy

RASGRF2 CDCP1

1.48e-03111562EFO_0004145, GO_0036273
DiseaseMalignant neoplasm of breast

RASGRF2 CENPF MYOD1 SIM1 CUBN TEK ADAM10 CNNM4 BMP4 ZNF532 WDCP DLEC1 ATM CDC27

1.74e-03107415614C0006142
DiseaseGastric Adenocarcinoma

SPEG MLH1 ATM

1.75e-03451563C0278701
DiseasePrenatal Exposure Delayed Effects

MYOD1 ATM

1.77e-03121562C0033054
DiseaseNeoplasm of uncertain or unknown behavior of bladder

TSC1 ATM

2.79e-03151562C0496930
DiseaseDyskinesia, Medication-Induced

GAD1 RASGRF1

2.79e-03151562C0751088
Diseasegamma-glutamylphenylalanine measurement

DPP6 TEK

2.79e-03151562EFO_0021142
DiseaseProteinuria

CUBN ADAMTS7

2.79e-03151562HP_0000093
DiseaseBenign neoplasm of bladder

TSC1 ATM

2.79e-03151562C0154017
DiseaseCarcinoma in situ of bladder

TSC1 ATM

2.79e-03151562C0154091
DiseaseDyskinesia, Drug-Induced

GAD1 RASGRF1

2.79e-03151562C0013386
DiseaseLeber congenital amaurosis

RDH12 AIPL1

3.17e-03161562cv:C0339527
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

TSC1 NEK1

3.17e-03161562DOID:0110861 (implicated_via_orthology)
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

CAMK2G MED13

3.59e-03171562DOID:0060307 (is_implicated_in)
DiseaseCarcinoma of bladder

TSC1 ATM

4.02e-03181562C0699885
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

CACNA1C THOC7 VPS45 CNNM4 SPAG16

4.30e-032001565EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
DiseaseCongenital hernia of foramen of Morgagni

MYOD1 FREM1

4.48e-03191562C0265699
DiseaseCongenital hernia of foramen of Bochdalek

MYOD1 FREM1

4.48e-03191562C0265700
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

MLH1 ATM

4.48e-03191562C1333991

Protein segments in the cluster

PeptideGeneStartEntry
KHHHSQEIIEFPAVL

ERI2

51

A8K979
ALLPHLHEHNLVKVT

COG7

331

P83436
EHTSDILRHHPGIVK

AIPL1

251

Q9NZN9
QFRTVHHHEPKVKEE

ARID4A

406

P29374
PHLEAKIRQTHSLAH

CTF1

21

Q16619
HVPPKVSHITFAHEV

ADAM10

371

O14672
IPLLQDHFTLQHTHI

ADAM21

571

Q9UKJ8
LDEDVLPKPSFHHHS

CDCP1

621

Q9H5V8
PVLTFEEVVHHDHNK

AMACR

296

Q9UHK6
HVAQELHFIEKAHTL

ATP13A1

756

Q9HD20
HPSGHLEHKTIDLVA

AASS

846

Q9UDR5
HDKHFEVLHSDLEPQ

CCNE2

126

O96020
DLHTATPLDFLHIFH

CCNI

141

Q14094
FLHENQLTHTDLKPE

CLK3

421

P49761
DRVHHEPQLSDKVHN

CALU

26

O43852
FELTIDHPHTHVVKC

CCNT1

146

O60563
TVRSFHHEEHLENIP

BMP4

116

P12644
HPLHHDTAILLTRKD

ADAMTS7

331

Q9UKP4
TEQLHELEKIFHFTH

ISX

91

Q2M1V0
KHLRTDAFSQHHLEP

PAX8

221

Q06710
VAHHIGKIPFHDLQS

RDH12

176

Q96NR8
SFLLKVLPADSHEHA

PNPLA2

96

Q96AD5
DPTFHTHQLHLVDLR

KIAA0100

1441

Q14667
LNVSHNHISHIPKEI

LRRD1

216

A4D1F6
FSVHHQPTVDKVHER

GRM5

41

P41594
FLHSHNIAHRDVKPE

MAPKAPK3

156

Q16644
VQPEPFFHKVVHSEH

NEK1

981

Q96PY6
FFHKVVHSEHLNLVP

NEK1

986

Q96PY6
TPNEHHDHLLSEHVI

MCM8

596

Q9UJA3
ELLTHIPRHKLNTFH

HECA

351

Q9UBI9
LIRIHAEPVIHFHKT

SBF2

376

Q86WG5
LPSVESHLENHKNVH

DST

631

Q03001
LHLDPTYHITDDHTK

SMPDL3A

46

Q92484
HPKIIHESGAQILRH

ASPDH

76

A6ND91
HHVPSDTEVINKVHL

LMLN

66

Q96KR4
TFDRSTKVLDFHHPH

GAD1

131

Q99259
TKVLDFHHPHQLLEG

GAD1

136

Q99259
ALHLAVIHQHEPFLD

NFKBIB

61

Q15653
NILKNPHFIFDVHVH

PLXNB2

1691

O15031
LLKPEEHSHFPAAVH

MYOD1

56

P15172
FLELQTASDPDLHHK

FAM205A

721

Q6ZU69
DGHHSIRHKFPINVL

FREM1

501

Q5H8C1
HFHHFLLSQTEKPAV

GLYR1

216

Q49A26
LVITYPHEHHALKSS

MEGF8

2596

Q7Z7M0
ETTQHFIDIKEHLHI

LMAN1

431

P49257
EGHPNIVKLHEVFHD

RPS6KA5

476

O75582
IVKLHEVFHDQLHTF

RPS6KA5

481

O75582
KHANIVTLHDIVHTD

CDK17

246

Q00537
NEALLHDEPHDHKLS

PLA2G4B

406

P0C869
ITSVLGKQHPIEAHH

HECTD4

251

Q9Y4D8
EHRAEFPEHATHLKK

PPP2R3A

446

Q06190
LHHVLEEAEKSHPDL

INF2

801

Q27J81
EVHFLLHPSDHENIQ

PARP14

1166

Q460N5
PNHLIHLMFETFHLE

CUBN

966

O60494
DHPHHTLFIILALAN

ATM

2551

Q13315
HLDDVTPFVELHKIH

IDI2

211

Q9BXS1
DISQKTVLPLHLVHH

CACNA1C

1996

Q13936
LPATLTDHHHLLFTF

DOCK7

636

Q96N67
FLSLQSEHKILHDQH

CENPF

1411

P49454
TIPSEIHKILHESHN

CPLANE1

3121

Q9H799
HPEHRHLSQLEAIKL

CACNA2D3

661

Q8IZS8
HLKEPFLEATDNSHL

SQLE

371

Q14534
NHVSSPFELSIHKHD

LUZP1

836

Q86V48
LASVNPSLVKVHIHH

LTBP2

466

Q14767
HLEEHISQSELTPHL

MARF1

236

Q9Y4F3
AVRSKVLEIHSHFPH

KANSL3

331

Q9P2N6
FLHHNKLTHTDLKPE

CLK4

276

Q9HAZ1
IIHPTADEKIHFQHT

DPP6

786

P42658
LAQSEEKPHVVAHFH

GYS1

166

P13807
EHLHAQTDFLPSIEK

CEP295

1461

Q9C0D2
ELEHIFPNLHHQLFK

CEP295

2066

Q9C0D2
HTQEELTHLALPCHV

DLEC1

1041

Q9Y238
HIHPSSALHEQETKL

DHX40

651

Q8IX18
LPKLHEFNAHDLSSV

DHX40

696

Q8IX18
CKEAINILSHLPSHH

CDC27

481

P30260
HIHQHDIVHRDLKPE

CAMK2G

126

Q13555
PHQVKHLYITKELEH

MICAL2

481

O94851
DKYHIHHISEPTRQE

PTPN13

1751

Q12923
NLFQHIVKEPTDNHH

HSF2

211

Q03933
LTEHEHFHTREKPFE

ZNF146

31

Q15072
EHEVRLSPHVLGHSK

ITPRIPL2

106

Q3MIP1
HPDLIQQIIKKHFAH

FBXL21P

101

Q9UKT6
TLEKLPTFDLASHHH

MAP3K5

336

Q99683
HALHNDLKVLFLDHP

REXO4

326

Q9GZR2
LPRAIHHAATHKELE

RIN1

161

Q13671
PHHILDFLEIDSTLH

SEL1L3

1001

Q68CR1
FNLLPHTENHSPEHK

SMYD4

426

Q8IYR2
KHEHIIHLEQVFETP

STK33

171

Q9BYT3
EHIHHSKLSPHLLEE

TDRD9

331

Q8NDG6
HELLAHTPHEHVERK

RASGRF2

396

O14827
HTPHEHVERKSLEFA

RASGRF2

401

O14827
KLVPNHHFDPHLEAS

NBEAL2

1841

Q6ZNJ1
QIALDSHPTIVSLHH

ID2

76

Q02363
EPQDLIEKTLYHHVH

SIM2

256

Q14190
EPQDLIEKTLYHHVH

SIM1

256

P81133
SLTLHHTEKPEHEDI

SIAH2

146

O43255
SEHHKPTLNQELHEH

SLC9A5

461

Q14940
PTLNQELHEHTFDHI

SLC9A5

466

Q14940
LARHHVHLKQPEEAL

SH3TC1

671

Q8TE82
PHVVDVTHHEDALTK

STEAP2

71

Q8NFT2
HLHVPSVQSDELLHS

MED13

2101

Q9UHV7
SVQSDELLHSKHSHP

MED13

2106

Q9UHV7
SLNHPHIIAIHEVFE

NUAK2

106

Q9H093
FVLHHDQTPESHILK

TEX45

301

Q8NA69
HVPHEKLQSHVTLGE

TEX45

346

Q8NA69
NVHPTKHEVHFLHEE

MLH1

306

P40692
TLHELLAHTPHEHVE

RASGRF1

391

Q13972
HLHLPTHDKETEELV

SMCR8

866

Q8TEV9
PVLLHLHQTAHADEF

STEAP1

41

Q9UHE8
FIKEAEHHCLLHSPI

ABHD10

221

Q9NUJ1
FQKHDPDLTLIRHHV

CMKLR2

191

P46091
DLHNSKIHQAITLHP

CHSY1

291

Q86X52
DLHNSKIHAAITLHP

CHSY3

381

Q70JA7
HLHFLHNETKPCDSV

CYSLTR1

256

Q9Y271
NHPVHFVFHDTKLDA

CNNM4

446

Q6P4Q7
HEFHPESHLQIKNHL

USP53

766

Q70EK8
VVDTHVRPEHSAKQH

RNF17

531

Q9BXT8
RKPVFHLSHEERVQH

XPR1

111

Q9UBH6
TKLHLTDSLHPQVTH

RAPGEF2

26

Q9Y4G8
LLQFHEHIPQHKSDG

ZNF532

1186

Q9HCE3
IKDHEHTDPHVQQIA

ZYG11B

701

Q9C0D3
HVRIHPELVTGSKDH

TSC1

226

Q92574
HLFEVALPKTAHHFV

TSC1

606

Q92574
QLIHHQETHSGLKPF

ZNF497

176

Q6ZNH5
VLLELVEHHLTPKSH

TNFAIP8L2

126

Q6P589
LLHHSAIPEDFLHIF

LINC00052

6

Q96N35
VHESHHPQIKEALNV

RALGAPA1

1306

Q6GYQ0
HQSHVLHLDVKPENL

SPEG

1711

Q15772
IFHLHELPEFNLIHS

PWP2

311

Q15269
PTVLLTLAHIFHHFA

RNF123

311

Q5XPI4
VKHLHIHTPLLDSER

RIPK2

46

O43353
ASYEPTIRVLHEKHH

SPAG16

221

Q8N0X2
SFEKVPDHHSCHLQL

FGD6

231

Q6ZV73
RFHHAHAQIPVVKTA

SENP6

136

Q9GZR1
HFVTTAPTLKLLNHH

SEZ6

56

Q53EL9
HQPFLHETLDHLIKG

VPS45

466

Q9NRW7
EHFHISPVKLHLSLS

VPS13C

3326

Q709C8
ELPEPLLTHKHFNAH

ARHGAP19

186

Q14CB8
ALAKVIQHHPDRHET

THOC7

121

Q6I9Y2
IQHHPDRHETLKELE

THOC7

126

Q6I9Y2
TVLHPKDFNHTDHFS

TEK

391

Q02763
KPHLEHLVADSHEST

PSME4

1361

Q14997
EAFHLIVPHVVNLVH

USP38

346

Q8NB14
THLKIHQLTHSEERP

ZNF770

201

Q6IQ21
HLLTHQRVHSGEKPF

ZNF234

526

Q14588
HLVNHLRVHTGEKPF

ZNF697

451

Q5TEC3
FDVHVSQHAPSILIH

ATP6V0A4

601

Q9HBG4
HLAQHTRIHTGEKPF

ZNF888

676

P0CJ79
SHLFLHLHTLQPEDS

TRBV4-3

91

A0A589
SHLLRHQIIHTGEKP

ZNF70

181

Q9UC06
HKQAPTHHQKIHPEE

ZNF41

296

P51814
SHLLVHQRIHTGEKP

ZNF552

281

Q9H707
LKDILHLAEHQTTHP

ZNF792

141

Q3KQV3
GFTDSLDLHKHQIIH

ZNF230

316

Q9UIE0
QLVFTHEDLPTLSHH

ZNF566

141

Q969W8
LIQHHIVHTGEKPYE

ZNF835

461

Q9Y2P0
FTHKPLLSSHFDQHL

ZNF687

836

Q8N1G0
SHLPELHIFHTEEKI

ZNF765

146

Q7L2R6
QHILLTDHIHTAEKP

ZNF713

246

Q8N859
LISHQNIHTEERPHK

ZNF597

356

Q96LX8
EPLDLTHIHFNQHKS

WDCP

281

Q9H6R7
SEHSKEVINHHPDVQ

TUT7

651

Q5VYS8
SHLFLHLHTLQPEDS

TRBV4-2

91

A0A539
SDFHLHQRVHTNEKP

ZNF619

201

Q8N2I2
SHLQAHERIHTGEKP

ZNF235

416

Q14590
ILHLAEHQETHPGQK

ZNF772

156

Q68DY9
PKILAHSIEHNQHIE

SAMD4A

106

Q9UPU9
THEPLVDTHLQHLKS

TBRG1

386

Q3YBR2
HALKHFQESSHPVAL

USP44

56

Q9H0E7
ILHLAEHDGTHPKRT

ZNF17

96

P17021
FLTQAHLVGHQKIHT

ZNF17

311

P17021
SHLLIHQRVHTGEKP

ZNF214

511

Q9UL59
VHLFVSTLHFPHEQK

TOR1B

136

O14657
DLILHEQIHSGEKPH

ZNF311

261

Q5JNZ3
SHFTQDLHPEQGIKH

ZNF722

91

A0A1W2PQL4
SHLIVHQRIHTGEKP

ZFP3

406

Q96NJ6
ELTEHQRIHTGIKPH

ZNF649

276

Q9BS31
HDFLHTPSDIKKQNH

VPS13D

2411

Q5THJ4
DVSHLNLHKTFCIPH

GLDC

746

P23378
IVPASSHHFLLKHLV

LRFN4

451

Q6PJG9
EKLEDTVKHHPHFLT

MYO1C

511

O00159
RLHIDHNKIEFIHPQ

MXRA5

131

Q9NR99