Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransporter activity

GABRB1 KCNH6 SLC26A3 SIDT2 TMEM184A SLC16A3 ABCA12 PIEZO1 ABCC11 LRP5 ATP13A5 BCL2 SLC45A1 TMEM184B ANO3 SLC2A1 SLC16A8 SLC5A3 SLC5A4

4.70e-0912896119GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

GABRB1 KCNH6 SLC26A3 SIDT2 SLC16A3 ABCA12 PIEZO1 ABCC11 LRP5 ATP13A5 BCL2 SLC45A1 ANO3 SLC2A1 SLC16A8 SLC5A3 SLC5A4

5.25e-0811806117GO:0022857
GeneOntologyMolecularFunctionD-glucose transmembrane transporter activity

SLC45A1 SLC2A1 SLC5A3 SLC5A4

9.50e-0725614GO:0055056
GeneOntologyMolecularFunctionhexose transmembrane transporter activity

SLC45A1 SLC2A1 SLC5A3 SLC5A4

9.50e-0725614GO:0015149
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC45A1 SLC2A1 SLC5A3 SLC5A4

1.31e-0627614GO:0015145
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC45A1 SLC2A1 SLC5A3 SLC5A4

1.77e-0629614GO:0051119
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR1N2 GABRB1 OR51A4 OR51A2 TAS2R10 RXFP2 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 RXFP1 OR1L3

2.10e-068846113GO:0004930
GeneOntologyMolecularFunctionolfactory receptor activity

OR1N2 OR51A4 OR51A2 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

6.01e-06431619GO:0004984
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC45A1 SLC2A1 SLC5A3 SLC5A4

8.09e-0642614GO:0015144
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC26A3 SLC16A3 ABCA12 ABCC11 ATP13A5 SLC45A1 SLC16A8 SLC5A3 SLC5A4

1.35e-05477619GO:0022804
GeneOntologyMolecularFunctioncarbohydrate:monoatomic cation symporter activity

SLC45A1 SLC5A3 SLC5A4

1.79e-0517613GO:0005402
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR1N2 GABRB1 OR51A4 OR51A2 TAS2R10 RXFP2 OR10V1 OR1P1 OR10A6 LRP5 OR1K1 OR5A1 RXFP1 OR1L3

4.44e-0513536114GO:0004888
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

SLC16A3 ABCC11 SLC16A8 SLC5A3

6.22e-0570614GO:1901618
GeneOntologyMolecularFunctionsymporter activity

SLC16A3 SLC45A1 SLC16A8 SLC5A3 SLC5A4

9.49e-05150615GO:0015293
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRB1 KCNH6 SLC26A3 SLC16A3 PIEZO1 ATP13A5 SLC45A1 ANO3 SLC5A3 SLC5A4

1.33e-047936110GO:0015075
GeneOntologyMolecularFunctionlactate transmembrane transporter activity

SLC16A3 SLC16A8

1.37e-046612GO:0015129
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC16A3 ABCC11 SLC2A1 SLC16A8

1.65e-0490614GO:0008028
GeneOntologyMolecularFunctionD-glucose:sodium symporter activity

SLC5A3 SLC5A4

1.91e-047612GO:0005412
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC26A3 SLC16A3 SLC45A1 SLC16A8 SLC5A3 SLC5A4

2.82e-04296616GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC26A3 SLC16A3 ATP13A5 SLC45A1 SLC5A3 SLC5A4

3.09e-04301616GO:0022853
GeneOntologyMolecularFunctionATPase-coupled lipid transmembrane transporter activity

ABCA12 ABCC11

3.26e-049612GO:0034040
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC26A3 SLC16A3 ABCC11 SLC2A1 SLC16A8

4.24e-04207615GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC26A3 SLC16A3 ABCC11 SLC2A1 SLC16A8

4.33e-04208615GO:0005342
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRB1 KCNH6 SLC26A3 SLC16A3 ABCC11 SLC45A1 ANO3 SLC5A3 SLC5A4

4.61e-04758619GO:0015318
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC16A3 SLC45A1 SLC5A3 SLC5A4

4.81e-04119614GO:0015294
GeneOntologyMolecularFunctionG protein activity

KRAS NRAS HRAS

7.81e-0459613GO:0003925
GeneOntologyMolecularFunctioncalcium-dependent phospholipid binding

CPNE2 CPNE4 CPNE7

8.20e-0460613GO:0005544
GeneOntologyMolecularFunctionlipid transmembrane transporter activity

ABCA12 ABCC11 SLC2A1

1.45e-0373613GO:0170055
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRB1 SLC26A3 ABCC11 ANO3

1.85e-03171614GO:0015103
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC26A3 SLC16A3 ABCC11 SLC2A1 SLC16A8

2.00e-03293615GO:0008514
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

KRAS NRAS HSP90AB4P ABCA12 HRAS ABCC11 ATP13A5 DYNC1H1

2.37e-03775618GO:0017111
GeneOntologyMolecularFunctionsolute:proton symporter activity

SLC16A3 SLC45A1

2.63e-0325612GO:0015295
GeneOntologyMolecularFunctionlipid transporter activity

ABCA12 ABCC11 ANO3 SLC2A1

3.04e-03196614GO:0005319
GeneOntologyMolecularFunctionpyrophosphatase activity

KRAS NRAS HSP90AB4P ABCA12 HRAS ABCC11 ATP13A5 DYNC1H1

3.85e-03839618GO:0016462
GeneOntologyMolecularFunctionGDP binding

KRAS NRAS HRAS

3.86e-03103613GO:0019003
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

KRAS NRAS HSP90AB4P ABCA12 HRAS ABCC11 ATP13A5 DYNC1H1

3.88e-03840618GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

KRAS NRAS HSP90AB4P ABCA12 HRAS ABCC11 ATP13A5 DYNC1H1

3.88e-03840618GO:0016818
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNH6 SLC16A3 PIEZO1 ATP13A5 SLC45A1 SLC5A3 SLC5A4

4.01e-03664617GO:0008324
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA12 ABCC11 ATP13A5

4.53e-03109613GO:0042626
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC11 SLC2A1

4.84e-0334612GO:0042910
GeneOntologyMolecularFunctionWnt-protein binding

SFRP1 LRP5

4.84e-0334612GO:0017147
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

GABRB1 SLC26A3 ANO3

6.62e-03125613GO:0015108
GeneOntologyMolecularFunctionodorant binding

OR10V1 OR1K1 OR5A1

6.91e-03127613GO:0005549
GeneOntologyMolecularFunctionprotein-membrane adaptor activity

KRAS HRAS

8.35e-0345612GO:0043495
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA12 ABCC11

9.84e-0349612GO:0140359
GeneOntologyMolecularFunctionbeta-tubulin binding

CLXN PACRG

9.84e-0349612GO:0048487
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRB1 ANO3

1.02e-0250612GO:0099095
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ABCA12 ANO3

1.06e-0251612GO:0140303
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRB1 SLC26A3 ANO3

1.11e-02151613GO:0008509
GeneOntologyMolecularFunctionATP hydrolysis activity

HSP90AB4P ABCA12 ABCC11 ATP13A5 DYNC1H1

1.11e-02441615GO:0016887
GeneOntologyBiologicalProcessdetection of stimulus

OR1N2 OR51A4 OR51A2 TAS2R10 PIEZO1 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 ANO3 OR1L3

1.11e-067226112GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1N2 OR51A4 OR51A2 TAS2R10 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

1.45e-064856110GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1N2 OR51A4 OR51A2 TAS2R10 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

2.90e-065246110GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1N2 OR51A4 OR51A2 TAS2R10 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

4.24e-065476110GO:0007606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR1N2 OR51A4 OR51A2 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

4.72e-06432619GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1N2 OR51A4 OR51A2 TAS2R10 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

7.31e-065826110GO:0050906
GeneOntologyBiologicalProcesssensory perception of smell

OR1N2 OR51A4 OR51A2 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

8.54e-06465619GO:0007608
GeneOntologyBiologicalProcessregulation of osteoblast proliferation

SFRP1 LRP5 BCL2

1.38e-0434613GO:0033688
GeneOntologyBiologicalProcessgland morphogenesis

SFRP1 SULF1 LRP5 BCL2 RXFP1

1.82e-04178615GO:0022612
GeneOntologyBiologicalProcessosteoblast proliferation

SFRP1 LRP5 BCL2

2.42e-0441613GO:0033687
GeneOntologyBiologicalProcesslactate transport

SLC16A3 SLC16A8

3.06e-049612GO:0015727
GeneOntologyBiologicalProcesslactate transmembrane transport

SLC16A3 SLC16A8

3.06e-049612GO:0035873
HumanPhenoLinear nevus sebaceous

KRAS NRAS HRAS

6.99e-083223HP:0010817
HumanPhenoHemimegalencephaly

KRAS AKT3 NRAS HRAS

2.54e-0714224HP:0007206
HumanPhenoLymphedema

KRAS NRAS PIEZO1 HRAS LRP5 BCL2

5.58e-0776226HP:0001004
HumanPhenoCranial asymmetry

KRAS AKT3 NRAS HRAS

5.99e-0717224HP:0000267
HumanPhenoNevus sebaceous

KRAS NRAS HRAS

6.96e-075223HP:0010815
HumanPhenoEpidermal nevus

KRAS NRAS HRAS

1.50e-0512223HP:0010816
HumanPhenoMegalencephaly

KRAS AKT3 NRAS HRAS

3.16e-0544224HP:0001355
HumanPhenoNevus spilus

NRAS HRAS

5.33e-053222HP:0025510
HumanPhenoPremature birth

KRAS SLC26A3 ABCA12 HRAS LRP5 CNOT1

7.59e-05177226HP:0001622
HumanPhenoProminent occiput

KRAS NRAS HRAS CNOT1

1.24e-0462224HP:0000269
HumanPhenoHemihypertrophy

KRAS NRAS HRAS

1.51e-0425223HP:0001528
HumanPhenoAdenoma sebaceum

KRAS NRAS HRAS

1.51e-0425223HP:0009720
HumanPhenoHypophosphatemic rickets

KRAS NRAS HRAS

1.51e-0425223HP:0004912
HumanPhenoThick lower lip vermilion

KRAS NRAS HRAS BAZ1B SLC2A1

2.30e-04136225HP:0000179
HumanPhenoAngiofibromas

KRAS NRAS HRAS

2.63e-0430223HP:0010615
HumanPhenoHyperphosphaturia

KRAS NRAS HRAS

2.63e-0430223HP:0003109
HumanPhenoAbnormal lymphocyte apoptosis

KRAS NRAS

2.64e-046222HP:0030886
HumanPhenoNon-medullary thyroid carcinoma

NRAS HRAS

2.64e-046222HP:0040198
HumanPhenoDecreased lymphocyte apoptosis

KRAS NRAS

2.64e-046222HP:0002731
HumanPhenoCavernous hemangioma

KRAS NRAS HRAS

2.91e-0431223HP:0001048
HumanPhenoTransitional cell carcinoma of the bladder

KRAS NRAS HRAS

2.91e-0431223HP:0006740
HumanPhenoPorencephalic cyst

KRAS NRAS HRAS

3.20e-0432223HP:0002132
HumanPhenoAbnormal blood ion concentration

KRAS SLC26A3 NRAS PIEZO1 HRAS BAZ1B BCL2 SLC2A1

3.39e-04445228HP:0003111
HumanPhenoAbnormal morphology of the vestibule of the inner ear

KRAS NRAS HRAS

3.51e-0433223HP:0011376
HumanPhenoBladder carcinoma

KRAS NRAS HRAS

3.51e-0433223HP:0002862
HumanPhenoCongenital giant melanocytic nevus

NRAS HRAS

3.69e-047222HP:0005600
HumanPhenoProminence of the premaxilla

NRAS HRAS

3.69e-047222HP:0010759
HumanPhenoGenu recurvatum

KRAS NRAS HRAS

3.84e-0434223HP:0002816
HumanPhenoAbnormality of dental color

KRAS NRAS HRAS

3.84e-0434223HP:0011073
HumanPhenoBladder neoplasm

KRAS NRAS HRAS

3.84e-0434223HP:0009725
HumanPhenoAbnormal urine phosphate concentration

KRAS NRAS HRAS

4.19e-0435223HP:0012599
HumanPhenoAbnormal lower lip morphology

KRAS NRAS ABCA12 HRAS BAZ1B SLC2A1

4.24e-04242226HP:0000178
HumanPhenoProminent lips

KRAS NRAS HRAS BAZ1B SLC2A1

4.36e-04156225HP:0000184
HumanPhenoCurly hair

KRAS NRAS HRAS

4.55e-0436223HP:0002212
HumanPhenoEnlarged thorax

KRAS NRAS HRAS LRP5

6.17e-0494224HP:0100625
HumanPhenoHyperextensibility of the knee

KRAS NRAS HRAS

6.23e-0440223HP:0010500
HumanPhenoPineal cyst

KRAS GALNT2

6.29e-049222HP:0012683
HumanPhenoHypoplasia of the zygomatic bone

KRAS BAZ1B CNOT1

7.20e-0442223HP:0010669
HumanPhenoLymphangiectasis

PIEZO1 HRAS

7.85e-0410222HP:0031842
HumanPhenoSporadic

KRAS NRAS HRAS RNF139

8.71e-04103224HP:0003745
HumanPhenoThick vermilion border

KRAS NRAS GALNT2 HRAS BAZ1B SLC2A1

9.06e-04279226HP:0012471
HumanPhenoNumerous nevi

NRAS HRAS

9.57e-0411222HP:0001054
HumanPhenoPrecocious puberty

KRAS NRAS HRAS BAZ1B LRP5

9.76e-04186225HP:0000826
HumanPhenoAbnormal urine anion concentration

KRAS NRAS HRAS

1.00e-0347223HP:0011866
HumanPhenoRickets

KRAS NRAS HRAS

1.00e-0347223HP:0002748
HumanPhenoHemiparesis

KRAS AKT3 HRAS SLC2A1

1.04e-03108224HP:0001269
HumanPhenoEarly onset of sexual maturation

KRAS NRAS HRAS BAZ1B LRP5

1.05e-03189225HP:0100000
HumanPhenoAbnormal pineal morphology

KRAS GALNT2

1.14e-0312222HP:0012681
HumanPhenoAbnormality of the premaxilla

NRAS HRAS

1.14e-0312222HP:0010758
HumanPhenoFetal neck anomaly

KRAS NRAS HRAS BAZ1B

1.15e-03111224HP:0025667
HumanPhenoKyphoscoliosis

KRAS NRAS GLS HRAS LRP5

1.24e-03196225HP:0002751
DomainCopine

CPNE2 CPNE4 CPNE7

2.61e-069603PF07002
DomainCopine

CPNE2 CPNE4 CPNE7

2.61e-069603IPR010734
DomainRelaxin_rcpt

RXFP2 RXFP1

1.01e-052602IPR008112
DomainOlfact_rcpt

OR1N2 OR51A4 OR51A2 OR10V1 OR10A6 OR1K1 OR5A1 OR1L3

3.52e-05393608IPR000725
DomainGPCR_Rhodpsn_7TM

OR1N2 OR51A4 OR51A2 RXFP2 OR10V1 OR10A6 OR1K1 OR5A1 RXFP1 OR1L3

4.92e-056706010IPR017452
Domain7tm_1

OR1N2 OR51A4 OR51A2 RXFP2 OR10V1 OR10A6 OR1K1 OR5A1 RXFP1 OR1L3

5.37e-056776010PF00001
DomainG_PROTEIN_RECEP_F1_1

OR1N2 OR51A4 OR51A2 RXFP2 OR10V1 OR10A6 OR1K1 OR5A1 RXFP1 OR1L3

5.92e-056856010PS00237
DomainSolute_trans_a

TMEM184A TMEM184B

6.06e-054602PF03619
DomainOstalpha/TMEM184C

TMEM184A TMEM184B

6.06e-054602IPR005178
DomainG_PROTEIN_RECEP_F1_2

OR1N2 OR51A4 OR51A2 RXFP2 OR10V1 OR10A6 OR1K1 OR5A1 RXFP1 OR1L3

6.37e-056916010PS50262
DomainGPCR_Rhodpsn

OR1N2 OR51A4 OR51A2 RXFP2 OR10V1 OR10A6 OR1K1 OR5A1 RXFP1 OR1L3

6.45e-056926010IPR000276
DomainMCT

SLC16A3 SLC16A8

1.01e-045602IPR004743
DomainRAS

KRAS NRAS HRAS

1.92e-0435603PS51421
DomainSmall_GTPase_Ras

KRAS NRAS HRAS

2.27e-0437603IPR020849
DomainNa/solute_symporter_CS

SLC5A3 SLC5A4

2.81e-048602IPR018212
DomainLDLR_class-A_CS

RXFP2 LRP5 RXFP1

2.86e-0440603IPR023415
DomainLdl_recept_a

RXFP2 LRP5 RXFP1

4.06e-0445603PF00057
Domain-

RXFP2 LRP5 RXFP1

4.34e-04466034.10.400.10
DomainLDLRA_1

RXFP2 LRP5 RXFP1

4.92e-0448603PS01209
DomainLDLRA_2

RXFP2 LRP5 RXFP1

5.23e-0449603PS50068
DomainLDrepeatLR_classA_rpt

RXFP2 LRP5 RXFP1

5.23e-0449603IPR002172
DomainLDLa

RXFP2 LRP5 RXFP1

5.23e-0449603SM00192
DomainNA_SOLUT_SYMP_1

SLC5A3 SLC5A4

5.48e-0411602PS00456
DomainNA_SOLUT_SYMP_2

SLC5A3 SLC5A4

6.56e-0412602PS00457
DomainSSF

SLC5A3 SLC5A4

6.56e-0412602PF00474
DomainNa/solute_symporter

SLC5A3 SLC5A4

6.56e-0412602IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A3 SLC5A4

6.56e-0412602PS50283
DomainC2_dom

CPNE2 C2CD6 CPNE4 CPNE7

1.91e-03164604IPR000008
DomainMFS_1

SLC16A3 SLC45A1 SLC16A8

1.95e-0377603PF07690
DomainMFS

SLC16A3 SLC45A1 SLC16A8

1.95e-0377603IPR011701
DomainVWFA

CPNE2 CPNE4 CPNE7

2.33e-0382603PS50234
DomainVWA

CPNE2 CPNE4 CPNE7

2.50e-0384603SM00327
DomainVWF_A

CPNE2 CPNE4 CPNE7

3.97e-0399603IPR002035
DomainMFS

SLC16A3 SLC2A1 SLC16A8

5.07e-03108603PS50850
Domain7TM_GPCR_Srsx

OR51A4 OR51A2 OR1L3

5.60e-03112603SM01381
DomainABC_transporter_CS

ABCA12 ABCC11

8.05e-0342602IPR017871
DomainC2

CPNE2 CPNE4 CPNE7

8.62e-03131603PF00168
DomainMFS_dom

SLC16A3 SLC2A1 SLC16A8

9.17e-03134603IPR020846
DomainRas

KRAS NRAS HRAS

9.55e-03136603PF00071
Domain-

KRAS NRAS ABCA12 HRAS ABCC11 NLRP4 DYNC1H1

9.69e-037466073.40.50.300
DomainC2

CPNE2 CPNE4 CPNE7

9.74e-03137603SM00239
DomainABC_tran

ABCA12 ABCC11

1.04e-0248602PF00005
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

KRAS AKT3 NRAS HRAS

8.86e-0814454M47390
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

KRAS AKT3 NRAS HRAS

1.21e-0715454M47389
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

KRAS AKT3 NRAS HRAS

1.21e-0715454M47475
PathwayREACTOME_ACTIVATION_OF_RAS_IN_B_CELLS

KRAS NRAS HRAS

3.03e-075453M26921
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS BCL2

3.39e-0719454M47793
PathwayWP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER

KRAS AKT3 NRAS CAMK4 HRAS

5.02e-0750455M39822
PathwayREACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ

KRAS NRAS HRAS

6.04e-076453M27951
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_RASSF1_TO_RAS_RASSF1_SIGNALING_PATHWAY

KRAS NRAS HRAS

6.04e-076453M47433
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX

KRAS NRAS HRAS

6.04e-076453M47931
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1

KRAS NRAS HRAS

6.04e-076453M47932
PathwayREACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS

KRAS NRAS HRAS

1.05e-067453M29717
PathwayREACTOME_SOS_MEDIATED_SIGNALLING

KRAS NRAS HRAS

1.05e-067453M19489
PathwayWP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR

KRAS AKT3 NRAS HRAS

1.09e-0625454M39794
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RASGAP

KRAS NRAS HRAS

1.68e-068453M47935
PathwayREACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS

KRAS NRAS HRAS

1.68e-068453M27919
PathwayWP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING

KRAS AKT3 NRAS HRAS

1.75e-0628454M39572
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY

KRAS AKT3 NRAS

2.52e-069453M47391
PathwayREACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN

KRAS NRAS HRAS

2.52e-069453M27156
PathwayREACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R

KRAS NRAS HRAS

2.52e-069453M27173
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS

KRAS NRAS HRAS

2.52e-069453M27904
PathwayKEGG_RENAL_CELL_CARCINOMA

KRAS AKT3 NRAS HRAS SLC2A1

2.73e-0670455M13266
PathwayKEGG_NEUROTROPHIN_SIGNALING_PATHWAY

KRAS AKT3 NRAS CAMK4 HRAS BCL2

2.77e-06126456M16763
PathwayREACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING

KRAS AKT3 NRAS HRAS BCL2

3.85e-0675455M27874
PathwayWP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS

KRAS AKT3 NRAS HRAS

3.92e-0634454M48081
PathwayREACTOME_MET_ACTIVATES_RAS_SIGNALING

KRAS NRAS HRAS

4.93e-0611453M27740
PathwayREACTOME_SIGNALING_BY_FGFR4_IN_DISEASE

KRAS NRAS HRAS

4.93e-0611453M27535
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.93e-0611453M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.93e-0611453M47371
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2

KRAS NRAS HRAS

4.93e-0611453M29814
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.93e-0611453M47436
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY

KRAS NRAS HRAS

4.93e-0611453M47432
PathwayREACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3

KRAS NRAS HRAS

4.93e-0611453M27911
PathwayPID_PI3K_PLC_TRK_PATHWAY

KRAS NRAS CAMK4 HRAS

4.95e-0636454M271
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR1N2 OR51A4 OR51A2 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

5.48e-06417459M4072
PathwayREACTOME_FLT3_SIGNALING

KRAS AKT3 NRAS HRAS

6.18e-0638454M29803
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

6.55e-0612453M47369
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

6.55e-0612453M47815
PathwayREACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS

KRAS NRAS HRAS

6.55e-0612453M29851
PathwayWP_RALA_DOWNSTREAM_REGULATED_GENES

KRAS NRAS HRAS

6.55e-0612453M39408
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

KRAS AKT3 NRAS HRAS BCL2

6.75e-0684455M39839
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

KRAS NRAS HRAS

8.50e-0613453M47594
PathwayREACTOME_P38MAPK_EVENTS

KRAS NRAS HRAS

8.50e-0613453M1441
PathwayKEGG_PROSTATE_CANCER

KRAS AKT3 NRAS HRAS BCL2

8.97e-0689455M13191
PathwayREACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES

KRAS NRAS HRAS

1.08e-0514453M27734
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.08e-0514453M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.08e-0514453M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.08e-0514453M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.08e-0514453M47378
PathwayREACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING

KRAS NRAS HRAS

1.08e-0514453M569
PathwayPID_TCR_RAS_PATHWAY

KRAS NRAS HRAS

1.08e-0514453M134
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.08e-0514453M47488
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_RAS

KRAS NRAS HRAS

1.08e-0514453M27908
PathwayREACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING

KRAS NRAS HRAS

1.08e-0514453M719
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII

KRAS NRAS HRAS

1.35e-0515453M29701
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47367
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47375
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.35e-0515453M47531
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

MBTPS1 SLC26A3 SLC16A3 ABCA12 ABCC11 ATP13A5 ANO3 SLC2A1 SLC16A8 SLC5A3 SLC5A4

1.45e-057364511M27287
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47801
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

KRAS NRAS HRAS

1.65e-0516453M562
PathwayREACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS

KRAS NRAS HRAS

1.65e-0516453M29847
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47483
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

KRAS NRAS HRAS

1.65e-0516453M41733
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

KRAS NRAS HRAS

1.65e-0516453M47682
PathwayREACTOME_SIGNALING_BY_ERBB2

KRAS AKT3 NRAS HRAS

1.87e-0550454M553
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.00e-0517453M47376
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY

KRAS NRAS HRAS

2.00e-0517453M47684
PathwayREACTOME_SIGNALING_BY_NTRK3_TRKC

KRAS NRAS HRAS

2.00e-0517453M27918
PathwayKEGG_ENDOMETRIAL_CANCER

KRAS AKT3 NRAS HRAS

2.19e-0552454M19877
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR3

KRAS NRAS HRAS

2.40e-0518453M27518
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

KRAS NRAS HRAS

2.40e-0518453M39737
PathwayREACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK

KRAS NRAS HRAS

2.40e-0518453M657
PathwayREACTOME_TIE2_SIGNALING

KRAS NRAS HRAS

2.40e-0518453M11932
PathwayREACTOME_SENSORY_PERCEPTION

OR1N2 OR51A4 OR51A2 TAS2R10 OR10V1 OR1P1 OR10A6 OR1K1 OR5A1 OR1L3

2.48e-056364510M41834
PathwayWP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT

KRAS AKT3 NRAS HRAS BCL2

2.52e-05110455M39492
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

KRAS AKT3 NRAS HRAS

2.55e-0554454M19818
PathwayPID_IL2_1PATHWAY

KRAS NRAS HRAS BCL2

2.74e-0555454M122
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR1N2 OR51A4 OR51A2 OR10V1 OR10A6 OR1K1 OR5A1 OR1L3

2.76e-05389458M14091
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_LIGAND_RESPONSIVE_EGFR_CANCER_VARIANTS

KRAS NRAS HRAS

2.84e-0519453M559
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

KRAS NRAS HRAS

2.84e-0519453M27423
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

KRAS NRAS HRAS

2.84e-0519453M41732
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

KRAS AKT3 NRAS HRAS

3.16e-0557454M19888
PathwayREACTOME_SIGNALLING_TO_RAS

KRAS NRAS HRAS

3.34e-0520453M12256
Pubmed

Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.

KRAS NRAS HRAS BCL2

9.15e-12462410490827
Pubmed

Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.

KRAS NRAS HRAS

5.39e-09362328116986
Pubmed

RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.

KRAS NRAS HRAS

5.39e-09362337013448
Pubmed

Mutations of RAS gene family in specimens of bladder cancer.

KRAS NRAS HRAS

5.39e-09362319101897
Pubmed

Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.

KRAS NRAS HRAS

5.39e-09362325977330
Pubmed

Promoter hypomethylation as potential confounder of Ras gene overexpression and their clinical significance in subsets of urothelial carcinoma of bladder.

KRAS NRAS HRAS

5.39e-09362333620658
Pubmed

A comprehensive survey of Ras mutations in cancer.

KRAS NRAS HRAS

5.39e-09362322589270
Pubmed

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.

KRAS NRAS HRAS

5.39e-09362323496764
Pubmed

Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.

KRAS NRAS HRAS

5.39e-0936237776260
Pubmed

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

KRAS NRAS HRAS

5.39e-09362328630043
Pubmed

Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.

KRAS NRAS HRAS

5.39e-09362328259994
Pubmed

The variable phenotype and low-risk nature of RAS-positive thyroid nodules.

KRAS NRAS HRAS

5.39e-09362326253102
Pubmed

Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.

KRAS NRAS HRAS

5.39e-09362316573741
Pubmed

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

KRAS NRAS HRAS

5.39e-09362325788415
Pubmed

Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.

KRAS NRAS HRAS

5.39e-09362320090846
Pubmed

Comparison of liver oncogenic potential among human RAS isoforms.

KRAS NRAS HRAS

5.39e-09362326799184
Pubmed

A pericyte origin of spinal cord scar tissue.

KRAS NRAS HRAS

5.39e-09362321737741
Pubmed

Ras isoforms: signaling specificities in CD40 pathway.

KRAS NRAS HRAS

5.39e-09362331906952
Pubmed

Partial functional overlap of the three ras genes in mouse embryonic development.

KRAS NRAS HRAS

5.39e-09362318059342
Pubmed

Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.

KRAS NRAS HRAS

5.39e-09362323240926
Pubmed

Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.

KRAS NRAS HRAS

5.39e-09362317943694
Pubmed

Absolute Quantification of Endogenous Ras Isoform Abundance.

KRAS NRAS HRAS

5.39e-09362326560143
Pubmed

Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.

KRAS NRAS HRAS

5.39e-09362317712732
Pubmed

Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.

KRAS NRAS HRAS

5.39e-09362324222113
Pubmed

Deciphering the RAS/ERK pathway in vivo.

KRAS NRAS HRAS

5.39e-09362328202657
Pubmed

Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.

KRAS NRAS HRAS

5.39e-09362316761621
Pubmed

Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.

KRAS NRAS HRAS

5.39e-09362322945650
Pubmed

Activation of RAS family genes in urothelial carcinoma.

KRAS NRAS HRAS

5.39e-09362319303097
Pubmed

The spatiotemporal regulation of RAS signalling.

KRAS NRAS HRAS

5.39e-09362327911734
Pubmed

Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.

KRAS NRAS HRAS

5.39e-09362320150643
Pubmed

Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.

KRAS NRAS HRAS

5.39e-09362320971740
Pubmed

Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

KRAS NRAS HRAS

5.39e-09362327119512
Pubmed

K-ras is an essential gene in the mouse with partial functional overlap with N-ras.

KRAS NRAS HRAS

5.39e-0936239334313
Pubmed

The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.

KRAS NRAS HRAS

2.16e-08462327936046
Pubmed

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

KRAS NRAS HRAS

2.16e-08462329502968
Pubmed

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

KRAS NRAS HRAS

2.16e-0846237972015
Pubmed

Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.

KRAS NRAS HRAS

2.16e-08462325999467
Pubmed

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.

KRAS NRAS HRAS

2.16e-08462310085069
Pubmed

Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.

KRAS NRAS HRAS

2.16e-08462338849523
Pubmed

Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members.

KRAS NRAS HRAS

2.16e-08462334948093
Pubmed

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.

KRAS NRAS HRAS

2.16e-0846239674433
Pubmed

Ras membrane orientation and nanodomain localization generate isoform diversity.

KRAS NRAS HRAS

2.16e-08462320080631
Pubmed

Quantification of spatiotemporal patterns of Ras isoform expression during development.

KRAS NRAS HRAS

2.16e-08462328117393
Pubmed

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.

KRAS NRAS HRAS

5.38e-08562322982107
Pubmed

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

KRAS NRAS HRAS

5.38e-08562334535655
Pubmed

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector.

KRAS NRAS BCL2

5.38e-08562310498879
Pubmed

The complexity of Raf-1 regulation.

KRAS NRAS HRAS

5.38e-0856239069260
Pubmed

Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

KRAS NRAS HRAS

5.38e-08562324746824
Pubmed

Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.

KRAS NRAS HRAS

5.38e-08562315558479
Pubmed

Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.

KRAS NRAS HRAS

1.07e-0766239753431
Pubmed

FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.

KRAS NRAS HRAS

1.07e-07662321072204
Pubmed

Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.

KRAS NRAS HRAS

1.07e-07662310882715
Pubmed

Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.

KRAS NRAS HRAS

1.07e-07662329615452
Pubmed

LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.

KRAS NRAS HRAS

1.07e-07662331337872
Pubmed

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

KRAS NRAS HRAS

1.88e-07762319487299
Pubmed

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

KRAS NRAS HRAS

1.88e-07762320526288
Pubmed

H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.

KRAS NRAS HRAS

1.88e-07762320179099
Pubmed

Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.

KRAS NRAS HRAS

1.88e-07762320012784
Pubmed

The structural basis of the activation of Ras by Sos.

KRAS NRAS HRAS

1.88e-0776239690470
Pubmed

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.

KRAS NRAS HRAS

1.88e-07762335904492
Pubmed

SmgGDS displays differential binding and exchange activity towards different Ras isoforms.

KRAS NRAS HRAS

1.88e-07762311948427
Pubmed

Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.

KRAS NRAS HRAS

1.88e-07762320860430
Pubmed

Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.

KRAS NRAS HRAS

1.88e-07762322199277
Pubmed

Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.

KRAS NRAS HRAS

3.00e-07862315064703
Pubmed

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

KRAS NRAS HRAS

3.00e-07862320150892
Pubmed

The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.

CPNE2 CPNE4 CPNE7

4.50e-0796239430674
Pubmed

Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.

KRAS NRAS HRAS

4.50e-0796239344703
Pubmed

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.

KRAS NRAS HRAS

4.50e-07962310783161
Pubmed

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

KRAS NRAS HRAS

6.42e-071062334215617
Pubmed

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.

KRAS NRAS HRAS

6.42e-071062329959233
Pubmed

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.

KRAS NRAS HRAS

8.81e-071162328263956
Pubmed

CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.

KRAS NRAS HRAS

1.17e-06126239269777
Pubmed

Ras effectors and their role in mitogenesis and oncogenesis.

KRAS NRAS HRAS

1.17e-06126239297626
Pubmed

K-RasV14I recapitulates Noonan syndrome in mice.

KRAS NRAS HRAS

1.94e-061462325359213
Pubmed

Ras signaling is essential for skin development.

KRAS NRAS HRAS

2.42e-061562323831572
Pubmed

The Ras branch of small GTPases: Ras family members don't fall far from the tree.

KRAS NRAS HRAS

2.42e-061562310712923
Pubmed

Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes.

KRAS NRAS HRAS

2.97e-06166238095010
Pubmed

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

KRAS NRAS

3.13e-06262219789336
Pubmed

Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis.

NRAS HRAS

3.13e-06262216624289
Pubmed

Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.

KRAS NRAS

3.13e-06262227698462
Pubmed

Frequent KRAS and HRAS mutations in squamous cell papillomas of the head and neck.

KRAS HRAS

3.13e-06262231960612
Pubmed

Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay.

NRAS HRAS

3.13e-0626221970154
Pubmed

Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.

KRAS HRAS

3.13e-06262220188103
Pubmed

Complete Screening of Exons 2, 3, and 4 of KRAS and NRAS Genes Reveals a Higher Number of Clinically Relevant Mutations than Food and Drug Administration Quantitative Polymerase Chain Reaction-Based Commercial Kits.

KRAS NRAS

3.13e-06262233053566
Pubmed

Promotion of cancer cell stemness by Ras.

KRAS HRAS

3.13e-06262233544116
Pubmed

Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents.

KRAS NRAS

3.13e-06262214688017
Pubmed

RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant.

KRAS NRAS

3.13e-06262220371679
Pubmed

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations.

KRAS NRAS

3.13e-06262239455841
Pubmed

Prevalence of RAS mutations and individual variation patterns among patients with metastatic colorectal cancer: A pooled analysis of randomised controlled trials.

KRAS NRAS

3.13e-06262226049686
Pubmed

Common KRAS and NRAS gene mutations in sporadic colorectal cancer in Northeastern Iranian patients.

KRAS NRAS

3.13e-06262229921458
Pubmed

Plasma membrane phosphatidylinositol 4-phosphate and 4,5-bisphosphate determine the distribution and function of K-Ras4B but not H-Ras proteins.

KRAS HRAS

3.13e-06262228939768
Pubmed

Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.

KRAS NRAS

3.13e-06262224737308
Pubmed

Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.

KRAS HRAS

3.13e-06262217210246
Pubmed

Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.

KRAS NRAS

3.13e-06262239273371
Pubmed

Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer.

KRAS NRAS

3.13e-06262225009008
Pubmed

Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations.

KRAS NRAS

3.13e-06262228859058
Pubmed

RAS mutations predict radiologic and pathologic response in patients treated with chemotherapy before resection of colorectal liver metastases.

KRAS NRAS

3.13e-06262225227306
Pubmed

Cervical mesonephric hyperplasia lacks KRAS/NRAS mutations.

KRAS NRAS

3.13e-06262228703285
Pubmed

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

KRAS NRAS

3.13e-06262217332249
Pubmed

Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia.

SLC16A3 SLC16A8

3.13e-06262221199217
InteractionHEPH interactions

KRAS NRAS HRAS

4.04e-076563int:HEPH
InteractionSLC5A3 interactions

KRAS NRAS TMEM184A HRAS SLC5A3

7.92e-0762565int:SLC5A3
InteractionTRPV2 interactions

KRAS NRAS HRAS

2.41e-0610563int:TRPV2
InteractionGTSF1 interactions

KRAS NRAS HRAS

4.39e-0612563int:GTSF1
InteractionITGB6 interactions

KRAS NRAS HRAS

7.24e-0614563int:ITGB6
InteractionELMOD3 interactions

KRAS NRAS HRAS

1.11e-0516563int:ELMOD3
InteractionSAMSN1 interactions

KRAS NRAS HRAS

1.11e-0516563int:SAMSN1
InteractionGYPC interactions

KRAS NRAS HRAS

1.91e-0519563int:GYPC
InteractionSLC29A1 interactions

KRAS SIDT2 NRAS HRAS RXFP1

2.15e-05121565int:SLC29A1
InteractionSUSD5 interactions

KRAS NRAS HRAS

2.24e-0520563int:SUSD5
InteractionSLC6A9 interactions

KRAS NRAS HRAS

2.24e-0520563int:SLC6A9
InteractionEBF3 interactions

CPNE2 CPNE4 CPNE7

3.01e-0522563int:EBF3
InteractionNECTIN1 interactions

KRAS NRAS HRAS

3.01e-0522563int:NECTIN1
InteractionSLC12A7 interactions

KRAS SIDT2 NRAS HRAS RXFP1

3.26e-05132565int:SLC12A7
InteractionSLC23A2 interactions

KRAS NRAS HRAS

3.46e-0523563int:SLC23A2
InteractionICMT interactions

KRAS NRAS HRAS SLC2A1

3.60e-0567564int:ICMT
InteractionTMEM161A interactions

KRAS NRAS HRAS SLC2A1

4.28e-0570564int:TMEM161A
InteractionZDHHC18 interactions

KRAS SIDT2 NRAS HRAS

5.32e-0574564int:ZDHHC18
InteractionPDLIM4 interactions

KRAS NRAS HRAS

5.67e-0527563int:PDLIM4
InteractionCARMIL2 interactions

KRAS NRAS SLC45A1

6.34e-0528563int:CARMIL2
InteractionRGL2 interactions

KRAS NRAS HRAS

6.34e-0528563int:RGL2
InteractionSLC35A2 interactions

KRAS NRAS HRAS

7.05e-0529563int:SLC35A2
InteractionLRRC8D interactions

SIDT2 HRAS RXFP1

7.05e-0529563int:LRRC8D
InteractionDCUN1D3 interactions

KRAS NRAS HRAS

7.05e-0529563int:DCUN1D3
InteractionTPD52L2 interactions

KRAS NRAS GLS HRAS CNOT1

7.24e-05156565int:TPD52L2
InteractionSLITRK2 interactions

KRAS NRAS

7.54e-055562int:SLITRK2
InteractionSLC1A4 interactions

KRAS NRAS HRAS

7.82e-0530563int:SLC1A4
InteractionCD276 interactions

KRAS NRAS HRAS

7.82e-0530563int:CD276
InteractionJAM3 interactions

KRAS NRAS HRAS

8.64e-0531563int:JAM3
InteractionDCBLD1 interactions

KRAS NRAS HRAS

8.64e-0531563int:DCBLD1
InteractionPLEKHO1 interactions

KRAS AKT3 NRAS HRAS

8.75e-0584564int:PLEKHO1
InteractionMEAK7 interactions

KRAS NRAS HRAS

9.52e-0532563int:MEAK7
InteractionCHMP6 interactions

KRAS NRAS HRAS

1.05e-0433563int:CHMP6
InteractionLRRC57 interactions

KRAS NRAS HRAS

1.25e-0435563int:LRRC57
InteractionSLC2A3 interactions

KRAS NRAS HRAS

1.25e-0435563int:SLC2A3
InteractionWLS interactions

KRAS SIDT2 NRAS HRAS

1.30e-0493564int:WLS
InteractionZDHHC20 interactions

KRAS NRAS HRAS

1.36e-0436563int:ZDHHC20
InteractionTMEM94 interactions

KRAS SIDT2 RXFP1

1.36e-0436563int:TMEM94
InteractionABHD5 interactions

PCNX2 KRAS NRAS

1.36e-0436563int:ABHD5
InteractionTMEM87A interactions

KRAS NRAS TMEM184A HRAS LRP5

1.70e-04187565int:TMEM87A
InteractionEPB41L1 interactions

KRAS NRAS HRAS EIF3I CWC22

1.70e-04187565int:EPB41L1
InteractionPCDH9 interactions

KRAS NRAS HRAS

1.73e-0439563int:PCDH9
InteractionNDRG3 interactions

KRAS NRAS HRAS

1.87e-0440563int:NDRG3
InteractionTRPM4 interactions

KRAS NRAS HRAS

1.87e-0440563int:TRPM4
InteractionRHBDD2 interactions

KRAS NRAS HRAS DYNC1H1

2.07e-04105564int:RHBDD2
InteractionRARS2 interactions

KRAS TMEM184A GLS SLC2A1

2.07e-04105564int:RARS2
InteractionCPNE8 interactions

KRAS NRAS HRAS EIF3I

2.07e-04105564int:CPNE8
InteractionC2orf72 interactions

KRAS NRAS

2.10e-048562int:C2orf72
InteractionATP2B4 interactions

KRAS SIDT2 NRAS HRAS RXFP1

2.11e-04196565int:ATP2B4
InteractionSLC7A1 interactions

KRAS NRAS TMEM184A HRAS SLC2A1

2.16e-04197565int:SLC7A1
InteractionPPFIBP2 interactions

KRAS NRAS HRAS

2.32e-0443563int:PPFIBP2
InteractionSFT2D1 interactions

KRAS NRAS HRAS

2.32e-0443563int:SFT2D1
InteractionNAV2 interactions

KRAS NRAS HRAS

2.32e-0443563int:NAV2
InteractionTMEM237 interactions

KRAS NRAS HRAS RXFP1 SLC5A4

2.43e-04202565int:TMEM237
InteractionZDHHC5 interactions

KRAS SIDT2 NRAS HRAS

2.57e-04111564int:ZDHHC5
InteractionHSP90AB2P interactions

KRAS NRAS HRAS SLC2A1

2.57e-04111564int:HSP90AB2P
InteractionITM2B interactions

KRAS NRAS HRAS BCL2

2.66e-04112564int:ITM2B
InteractionNHSL3 interactions

KRAS SFRP1 NRAS HRAS

2.75e-04113564int:NHSL3
InteractionSLCO4A1 interactions

KRAS NRAS HRAS

2.83e-0446563int:SLCO4A1
InteractionTMEM230 interactions

KRAS NRAS HRAS

2.83e-0446563int:TMEM230
InteractionTMEM165 interactions

KRAS NRAS HRAS RNF139

3.04e-04116564int:TMEM165
InteractionPLSCR3 interactions

KRAS NRAS HRAS

3.22e-0448563int:PLSCR3
InteractionZBTB12 interactions

KRAS HRAS

3.36e-0410562int:ZBTB12
InteractionZDHHC9 interactions

SIDT2 NRAS HRAS

3.42e-0449563int:ZDHHC9
InteractionPHLDB1 interactions

KRAS NRAS HRAS

3.42e-0449563int:PHLDB1
InteractionFRK interactions

CAMK4 CNOT1 DYNC1H1

3.63e-0450563int:FRK
InteractionDOCK8 interactions

KRAS NRAS HRAS CPNE7

3.80e-04123564int:DOCK8
InteractionABCC5 interactions

KRAS NRAS RXFP1

3.85e-0451563int:ABCC5
InteractionCCNY interactions

KRAS NRAS HRAS

3.85e-0451563int:CCNY
InteractionRASSF5 interactions

KRAS NRAS HRAS

4.08e-0452563int:RASSF5
InteractionCT55 interactions

CPNE2 C2CD6 CNOT1

4.08e-0452563int:CT55
InteractionHSP90AB4P interactions

AKT3 HSP90AB4P TMEM184B SLC2A1

4.16e-04126564int:HSP90AB4P
InteractionBAIAP2L1 interactions

KRAS NRAS TMEM184A HRAS

4.55e-04129564int:BAIAP2L1
InteractionSLC12A4 interactions

KRAS NRAS HRAS RXFP1

4.55e-04129564int:SLC12A4
InteractionHBZ interactions

KRAS NRAS HRAS

4.56e-0454563int:HBZ
InteractionRALGPS2 interactions

KRAS NRAS HRAS

4.56e-0454563int:RALGPS2
InteractionRAB23 interactions

KRAS NRAS HRAS

4.56e-0454563int:RAB23
InteractionEFNB3 interactions

KRAS NRAS HRAS

4.81e-0455563int:EFNB3
InteractionRAP2C interactions

KRAS NRAS HRAS

4.81e-0455563int:RAP2C
InteractionBLID interactions

HRAS BCL2

4.92e-0412562int:BLID
InteractionCCIN interactions

KRAS HSP90AB4P

4.92e-0412562int:CCIN
InteractionPLCD1 interactions

KRAS NRAS HRAS

5.08e-0456563int:PLCD1
InteractionLLGL2 interactions

KRAS HSP90AB4P HRAS DYNC1H1

5.10e-04133564int:LLGL2
InteractionCD44 interactions

KRAS AKT3 NRAS SLC16A3 HRAS

5.25e-04239565int:CD44
InteractionCYP51A1 interactions

KRAS NRAS HRAS RXFP1

5.25e-04134564int:CYP51A1
InteractionEHBP1L1 interactions

KRAS NRAS HRAS

5.35e-0457563int:EHBP1L1
InteractionSLC4A2 interactions

KRAS SIDT2 NRAS RXFP1

5.40e-04135564int:SLC4A2
InteractionFAM110C interactions

CAMK4 HRAS

5.80e-0413562int:FAM110C
InteractionRASGRP2 interactions

KRAS NRAS

5.80e-0413562int:RASGRP2
InteractionRCE1 interactions

KRAS NRAS

5.80e-0413562int:RCE1
InteractionHM13 interactions

KRAS NRAS HRAS RNF139

5.87e-04138564int:HM13
InteractionUSP53 interactions

HRAS BAZ1B DYNC1H1 CPNE7

5.87e-04138564int:USP53
InteractionPIK3CG interactions

KRAS NRAS HRAS

5.92e-0459563int:PIK3CG
InteractionDHRS7 interactions

KRAS SIDT2 NRAS RXFP1

6.03e-04139564int:DHRS7
InteractionACSL4 interactions

KRAS NRAS HRAS SLC2A1

6.19e-04140564int:ACSL4
InteractionMARVELD2 interactions

KRAS NRAS HRAS

6.22e-0460563int:MARVELD2
InteractionF11R interactions

KRAS NRAS HRAS

6.22e-0460563int:F11R
InteractionGRK6 interactions

KRAS NRAS HSP90AB4P DYNC1H1

6.36e-04141564int:GRK6
InteractionNR2C2AP interactions

KRAS SLC16A3

6.75e-0414562int:NR2C2AP
InteractionRLN2 interactions

RXFP2 RXFP1

6.75e-0414562int:RLN2
Cytoband9q33.2

OR1N2 OR1K1 OR1L3

2.07e-05396239q33.2
CytobandEnsembl 112 genes in cytogenetic band chr16q24

MBTPS1 PIEZO1 CPNE7

8.46e-04136623chr16q24
CytobandEnsembl 112 genes in cytogenetic band chr9q33

OR1N2 OR1K1 OR1L3

8.83e-04138623chr9q33
Cytoband16q24.3

PIEZO1 CPNE7

2.28e-035262216q24.3
Cytoband11p15.4

OR51A4 OR51A2 OR10A6

2.55e-0320062311p15.4
GeneFamilyCopines

CPNE2 CPNE4 CPNE7

1.76e-069513829
GeneFamilyOlfactory receptors, family 1

OR1N2 OR1P1 OR1K1 OR1L3

4.76e-0640514147
GeneFamilyRelaxin family peptide receptors

RXFP2 RXFP1

4.66e-054512217
GeneFamilyRAS type GTPase family

KRAS NRAS HRAS

8.99e-0531513389
GeneFamilySolute carriers

SLC26A3 SLC16A3 SLC45A1 SLC2A1 SLC16A8 SLC5A3 SLC5A4

1.14e-04395517752
GeneFamilyOlfactory receptors, family 51

OR51A4 OR51A2

6.84e-0344512164
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_500

GABRB1 MBTPS1 AKT3 SFRP1 CLXN SULF1 BAZ1B RXFP1

6.18e-06416518gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_200

GABRB1 SULF1 RXFP1

2.55e-0524513gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_200_k2
ToppCellAdult-Immune-T_lymphocyte-D122|Adult / Lineage, Cell type, age group and donor

PCNX2 AKT3 CAMK4 BCL2 CPNE7

4.81e-0618061506c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CAMK4 GLS RXFP1 CPNE4 ANO3

6.26e-0619061549e09cdb843b3d889a06a811aa5affae68b25a75
ComputationalGenes in the cancer module 186.

SLC26A3 SLC16A3 SLC16A8

3.78e-0520363MODULE_186
ComputationalGenes in the cancer module 71.

SLC26A3 SLC16A3 SLC16A8

5.09e-0522363MODULE_71
DrugL 744832

KRAS NRAS HRAS

7.31e-084613ctd:C096898
DrugAC1L32OA

KRAS NRAS HRAS

1.52e-069613CID000107745
DrugPemetrexed

KRAS NRAS ABCC11 BCL2

4.84e-0642614ctd:D000068437
Drugisoprene

KRAS HRAS

7.06e-062612ctd:C005059
DrugTetranitromethane

KRAS HRAS

2.11e-053612ctd:D013774
DrugGGTI 2147

KRAS NRAS

2.11e-053612ctd:C466792
DrugSaponins

SLC16A3 GLS BCL2 SLC2A1

2.17e-0561614ctd:D012503
DiseaseHemimegalencephaly

KRAS AKT3 NRAS HRAS

2.01e-106584C0431391
DiseaseVerrucous epidermal nevus

KRAS NRAS HRAS

7.21e-093583C0362030
DiseaseNevus Sebaceus of Jadassohn

KRAS NRAS HRAS

7.21e-093583C4552097
DiseaseOrganoid Nevus Phakomatosis

KRAS NRAS HRAS

7.21e-093583C0265329
DiseaseLinear nevus sebaceous syndrome

KRAS NRAS HRAS

7.21e-093583cv:C4552097
DiseaseNevus sebaceous

KRAS NRAS HRAS

7.21e-093583C3854181
DiseaseInflammatory linear verrucous epidermal nevus

KRAS NRAS HRAS

7.21e-093583C0473574
DiseaseSCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME

KRAS NRAS HRAS

7.21e-093583163200
Diseaselinear nevus sebaceous syndrome (is_implicated_in)

KRAS NRAS HRAS

7.21e-093583DOID:0111530 (is_implicated_in)
DiseaseNoonan syndrome 3 (implicated_via_orthology)

KRAS NRAS HRAS

7.21e-093583DOID:0060581 (implicated_via_orthology)
DiseaseLinear Verrucous Epidermal Nevus

KRAS NRAS HRAS

7.21e-093583C3179502
Diseasecervical cancer (implicated_via_orthology)

KRAS NRAS HRAS

7.21e-093583DOID:4362 (implicated_via_orthology)
DiseaseNEVUS, EPIDERMAL (disorder)

KRAS NRAS HRAS

7.19e-085583C0334082
DiseaseFollicular thyroid carcinoma

KRAS NRAS HRAS

7.19e-085583C0206682
DiseaseRASopathy (implicated_via_orthology)

KRAS NRAS HRAS

6.00e-079583DOID:0080690 (implicated_via_orthology)
Diseaseheart disease (implicated_via_orthology)

KRAS NRAS HRAS CNOT1

9.44e-0738584DOID:114 (implicated_via_orthology)
DiseaseNoonan Syndrome 1

KRAS NRAS HRAS

1.18e-0611583C4551602
DiseaseTurner Syndrome, Male

KRAS NRAS HRAS

1.18e-0611583C0041409
DiseaseFemale Pseudo-Turner Syndrome

KRAS NRAS HRAS

1.18e-0611583C1527404
Diseasekidney cancer (implicated_via_orthology)

KRAS NRAS HRAS

1.18e-0611583DOID:263 (implicated_via_orthology)
DiseaseMalformations of Cortical Development

AKT3 HRAS DYNC1H1

2.58e-0614583C1955869
DiseaseCortical Dysplasia

AKT3 HRAS DYNC1H1

2.58e-0614583C0431380
DiseaseRASopathy

KRAS NRAS HRAS

3.22e-0615583cv:C5555857
DiseaseRAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER

KRAS NRAS

3.80e-062582614470
DiseaseAutoimmune lymphoproliferative syndrome type 4

KRAS NRAS

3.80e-062582cv:C2674723
Diseaseautoimmune lymphoproliferative syndrome type 4 (is_implicated_in)

KRAS NRAS

3.80e-062582DOID:0110117 (is_implicated_in)
DiseaseMELANOCYTIC NEVUS SYNDROME, CONGENITAL

NRAS HRAS

3.80e-062582137550
DiseaseMelanocytic nevus

NRAS HRAS

3.80e-062582cv:C0027962
DiseaseRAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER

KRAS NRAS

3.80e-062582C2674723
Diseaselarge congenital melanocytic nevus (is_implicated_in)

NRAS HRAS

3.80e-062582DOID:0111359 (is_implicated_in)
DiseaseLarge congenital melanocytic nevus

NRAS HRAS

3.80e-062582cv:C1842036
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

KRAS NRAS HRAS

6.83e-0619583C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

KRAS NRAS HRAS

6.83e-0619583C1843181
DiseaseCardio-facio-cutaneous syndrome

KRAS NRAS HRAS

6.83e-0619583C1275081
DiseaseCostello syndrome (disorder)

KRAS NRAS HRAS

6.83e-0619583C0587248
Diseaseleukemia (implicated_via_orthology)

KRAS NRAS HRAS

6.83e-0619583DOID:1240 (implicated_via_orthology)
DiseaseNeoplastic Cell Transformation

KRAS HRAS BCL2 EIF3I SLC2A1

8.09e-06139585C0007621
DiseaseLEOPARD Syndrome

KRAS NRAS HRAS

1.08e-0522583C0175704
Diseasestomatocytic anemia

PIEZO1 SLC2A1

1.14e-053582C0272048
DiseaseStomatocytosis Result

PIEZO1 SLC2A1

1.14e-053582C0677598
DiseaseGIANT PIGMENTED HAIRY NEVUS

NRAS HRAS

1.14e-053582C1842036
Diseasenucleotide measurement

AKT3 GALNT2 SULF1 GTDC1

1.32e-0573584EFO_0010513
DiseaseNoonan Syndrome

KRAS NRAS HRAS

1.42e-0524583C0028326
Diseaseparacentral lobule volume measurement

KRAS NRAS PACRG

1.61e-0525583EFO_0010317
DiseaseNEVUS, EPIDERMAL

NRAS HRAS

2.27e-054582162900
DiseaseMalignant neoplasm of penis

KRAS HRAS

2.27e-054582C0153601
DiseasePenile Neoplasms

KRAS HRAS

2.27e-054582C0030849
DiseaseNevus, Keratinocytic, Nonepidermolytic

NRAS HRAS

2.27e-054582C4011754
DiseaseBLADDER CANCER

KRAS HRAS

2.27e-054582109800
DiseaseEpidermal nevus

NRAS HRAS

2.27e-054582cv:C0334082
DiseaseMalignant tumor of urinary bladder

KRAS HRAS

2.27e-054582cv:C0005684
DiseaseThyroid cancer, nonmedullary, 2

NRAS HRAS

2.27e-054582cv:C4225426
DiseaseMalignant tumor of cervix

KRAS HRAS

2.27e-054582C0007847
Diseaseepidermal nevus (is_implicated_in)

NRAS HRAS

2.27e-054582DOID:0111162 (is_implicated_in)
DiseaseTHYROID CANCER, NONMEDULLARY, 2

NRAS HRAS

2.27e-054582188470
DiseasePapillary thyroid carcinoma

KRAS NRAS HRAS DYNC1H1

2.53e-0586584C0238463
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

KRAS NRAS HRAS

2.54e-0529583DOID:11984 (implicated_via_orthology)
Diseasecolorectal cancer (implicated_via_orthology)

KRAS NRAS HRAS

2.82e-0530583DOID:9256 (implicated_via_orthology)
Diseaseintestinal cancer (implicated_via_orthology)

KRAS NRAS HRAS

3.43e-0532583DOID:10155 (implicated_via_orthology)
Diseaseprostate cancer (implicated_via_orthology)

KRAS NRAS HRAS

3.77e-0533583DOID:10283 (implicated_via_orthology)
DiseaseTHYROID CANCER, NONMEDULLARY, 2

NRAS HRAS

3.78e-055582C4225426
DiseaseMalignant neoplasm of thyroid

KRAS NRAS

3.78e-055582C0007115
DiseaseCetuximab response

KRAS NRAS

3.78e-055582cv:CN077967
DiseaseCervix carcinoma

KRAS HRAS

3.78e-055582C0302592
DiseasePanitumumab response

KRAS NRAS

3.78e-055582cv:CN077999
DiseaseThyroid Neoplasm

KRAS NRAS HRAS

5.34e-0537583C0040136
DiseasePleocytosis

KRAS NRAS

5.67e-056582C0151857
DiseaseAutoimmune lymphoproliferative syndrome

KRAS NRAS

5.67e-056582cv:CN301239
DiseaseCarcinoma in situ of uterine cervix

KRAS HRAS

5.67e-056582C0851140
Diseaseseminoma (is_implicated_in)

KRAS HRAS

5.67e-056582DOID:4440 (is_implicated_in)
DiseaseLeukocytosis

KRAS NRAS

5.67e-056582C0023518
DiseaseLymphoma

KRAS NRAS BCL2

6.76e-0540583C0024299
DiseaseMultiple Myeloma

KRAS NRAS BCL2

7.83e-0542583C0026764
DiseaseThyroid cancer, follicular

NRAS HRAS

7.92e-057582C2931367
Diseasehigh grade glioma (implicated_via_orthology)

KRAS NRAS HRAS

9.01e-0544583DOID:3070 (implicated_via_orthology)
DiseaseThyroid carcinoma

KRAS NRAS HRAS

9.01e-0544583C0549473
DiseaseAlzheimer's disease biomarker measurement, brain volume measurement

KRAS NRAS

1.06e-048582EFO_0006514, EFO_0006930
DiseaseNeuroblastoma

KRAS NRAS HRAS

1.10e-0447583C0027819
DiseaseNoonan syndrome

KRAS NRAS

1.35e-049582cv:C0028326
Diseasethyroid gland papillary carcinoma (is_implicated_in)

NRAS HRAS

1.69e-0410582DOID:3969 (is_implicated_in)
Diseasetemporomandibular joint disorder

SFRP1 RXFP2

1.69e-0410582EFO_0005279
Diseasecancer (implicated_via_orthology)

KRAS AKT3 NRAS HSP90AB4P HRAS

1.84e-04268585DOID:162 (implicated_via_orthology)
Diseasehair colour measurement

KRAS NRAS PIEZO1 LRP5 SLC45A1 PACRG CPNE7

1.98e-04615587EFO_0007822
Diseaseentorhinal cortical volume, Alzheimer's disease biomarker measurement

KRAS NRAS

2.06e-0411582EFO_0005092, EFO_0006514
Diseasegallbladder neoplasm

KRAS BCL2

2.06e-0411582C0016978
Diseaseendometriosis (implicated_via_orthology)

KRAS BCL2

2.06e-0411582DOID:289 (implicated_via_orthology)
DiseaseMalignant neoplasm of gallbladder

KRAS BCL2

2.06e-0411582C0153452
DiseaseColorectal Neoplasms

KRAS SFRP1 NRAS ABCA12 BCL2

2.15e-04277585C0009404
DiseaseColonic Neoplasms

KRAS BCL2 EIF3I SLC2A1

2.31e-04152584C0009375
DiseaseMalignant tumor of colon

KRAS BCL2 EIF3I SLC2A1

2.75e-04159584C0007102
Diseasecarcinoma (implicated_via_orthology)

KRAS NRAS HRAS

2.76e-0464583DOID:305 (implicated_via_orthology)
Diseaseimidazole lactate measurement

SLC16A3 CNOT1

2.92e-0413582EFO_0800004
Diseasemiddle temporal gyrus volume measurement, Alzheimer's disease biomarker measurement

KRAS NRAS

2.92e-0413582EFO_0006514, EFO_0010316
DiseaseNeoplasms, Experimental

KRAS NRAS HRAS

3.02e-0466583C0027659
DiseaseDisease Exacerbation

KRAS HRAS ABCC11 BCL2

3.16e-04165584C0235874
Diseasewhole-brain volume, Alzheimer's disease biomarker measurement

KRAS NRAS

3.40e-0414582EFO_0005089, EFO_0006514
Diseaserenal cell carcinoma (is_implicated_in)

AKT3 BCL2 RNF139

3.44e-0469583DOID:4450 (is_implicated_in)
Diseasecardiomyopathy (implicated_via_orthology)

KRAS NRAS HRAS

3.75e-0471583DOID:0050700 (implicated_via_orthology)
DiseaseLeukemia, Myelocytic, Acute

KRAS NRAS HRAS BCL2

3.78e-04173584C0023467
Diseasedysmenorrheic pain measurement

KRAS NRAS

4.48e-0416582EFO_0007889

Protein segments in the cluster

PeptideGeneStartEntry
FIVFLACLGVMGFFY

ATP13A5

401

Q4VNC0
EIGLMNFVLGFFCCF

CDIP1

156

Q9H305
FLDYILGGCQLMFTV

CPNE2

296

Q96FN4
GMAFITYVCVNLFFG

ABCA12

2096

Q86UK0
LFGDVAMVVEFLSCY

BAZ1B

606

Q9UIG0
LCFVMEYVNGGELFF

AKT3

221

Q9Y243
IVGLCVFFYGLFTMN

ANO3

411

Q9BYT9
YMRTGEGFLCVFAIN

HRAS

71

P01112
YMRTGEGFLCVFAIN

KRAS

71

P01116
YMRTGEGFLCVFAIN

NRAS

71

P01111
LCEMTFPYEFFARQG

PACRG

116

Q96M98
DMVGILDFYFQLCSI

GLS

406

O94925
LVAFCVAFGLSYGMV

SLC16A8

346

O95907
QMFFFVFLGGADCVL

OR10V1

101

Q8NGI7
GQDVIFGCEVFAYPM

KAZALD1

186

Q96I82
MGYFVEVLGAPFTCF

MBTPS1

671

Q14703
FIVGMCFQYVEQLCG

SLC2A1

416

P11166
LVVFCIFFGISYGMV

SLC16A3

321

O15427
CGFEPFYDERGDQFM

CAMK4

236

Q16566
CAEISMIGQFGVGFY

HSP90AB4P

96

Q58FF6
IAGGLFVMDKFYFEE

GALNT2

306

Q10471
SLFVMGGVYFVCQRV

LRP5

1396

O75197
DGFCELFGYSRVEVM

KCNH6

46

Q9H252
IFVKIFFQELCEYMG

CWC22

581

Q9HCG8
CRLEVEFMFSYGNFG

C2CD6

231

Q53TS8
CTYLLEQIDMLFFGG

PCNX2

976

A6NKB5
AAQFFFFVGMGLSEC

OR5A1

101

Q8NGJ0
GGYMVSCIIFFFVVL

ABCC11

801

Q96J66
IDIYLMGCFVFVFLA

GABRB1

306

P18505
GQVDSLAIFYCLFEM

NLRP4

546

Q96MN2
IDVIYGFFGALCLMV

OR51A2

196

Q8NGJ7
IDVIYGFFGALCLMV

OR51A4

196

Q8NGJ6
AGCLTQMYFFFALGV

OR1K1

96

Q8NGR3
FLDYIMGGCQIQFTV

CPNE4

296

Q96A23
FLDYIMGGCQIHFTV

CPNE7

371

Q9UBL6
MGYQCFVSFFDLRDP

EIF3I

116

Q13347
FDFQAMGRIFVGLCQ

DYNC1H1

1936

Q14204
EFFGVAMLEAVYCGC

GTDC1

371

Q4AE62
LFYTDFMGEVVFQGD

SLC45A1

576

Q9Y2W3
MYFILLFGGAECFLL

OR10A6

101

Q8NH74
ECLAQMYFFLVFGNI

OR1L3

96

Q8NH93
AQLYFLLMFGGLDNC

OR1N2

116

Q8NGR9
CLAQLYFFLTFGDMD

OR1P1

111

Q8NH06
IEFIFGVVMFGNGAY

RNF139

471

Q8WU17
FILYFIGMAIEISCF

TAS2R10

236

Q9NYW0
EAYVSGMLFCLGIFL

SIDT2

291

Q8NBJ9
AAGYQDFIICVEMFF

TMEM184B

291

Q9Y519
AAGYQNFIICVEMLF

TMEM184A

301

Q6ZMB5
DCLMGVYLFFVGIFD

RXFP2

461

Q8WXD0
GLFAVCSLGIFMFVY

SLC5A3

701

P53794
FILMGFAFNEVGGYE

SLC5A4

216

Q9NY91
GDCFGIAMVAFAVAF

SLC26A3

341

P40879
VRDSCEPVMQFFGFY

SFRP1

136

Q8N474
RIVAFFEFGGVMCVE

BCL2

146

P10415
ADFMQEVGYGFCASI

CNOT1

256

A5YKK6
KYCFEVFDLNGDGFI

CLXN

106

Q9HAE3
DCLMGIYLFVIGGFD

RXFP1

451

Q9HBX9
MELVAGCYEQVLFGF

PAK1IP1

1

Q9NWT1
TVLYCGEVAFGLYMF

XKR3

41

Q5GH77
FYKFGLEICFLMAVN

PIEZO1

991

Q92508
CEFATGFLEYFDMNT

SULF1

791

Q8IWU6
GLYVCMNTFLAFGRE

USP13

61

Q92995