Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR10 TLR1 IL18RAP	4.44e-05	16	88	3	GO:0061809
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR10 TLR1	1.15e-04	4	88	2	GO:0035663
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	LRP6 LRP5	1.74e-04	5	88	2	GO:1990851
Domain	Cadherin_tail	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	8.01e-07	37	88	5	PF15974
Domain	Cadherin_CBD	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	8.01e-07	37	88	5	IPR031904
Domain	Cadherin_C	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.53e-06	42	88	5	IPR032455
Domain	Cadherin_C_2	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.53e-06	42	88	5	PF16492
Domain	Cadherin_2	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.37e-05	65	88	5	PF08266
Domain	Cadherin_N	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.37e-05	65	88	5	IPR013164
Domain	LRP5/6	LRP6 LRP5	2.19e-05	2	88	2	IPR017049
Domain	TIR	TLR10 TLR1 IL18RAP	1.26e-04	21	88	3	SM00255
Domain	TIR	TLR10 TLR1 IL18RAP	1.46e-04	22	88	3	PF01582
Domain	Cadherin_CS	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.65e-04	109	88	5	IPR020894
Domain	-	TLR10 TLR1 IL18RAP	1.67e-04	23	88	3	3.40.50.10140
Domain	TIR	TLR10 TLR1 IL18RAP	1.90e-04	24	88	3	PS50104
Domain	CADHERIN_1	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.95e-04	113	88	5	PS00232
Domain	Cadherin	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.95e-04	113	88	5	PF00028
Domain	CADHERIN_2	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.03e-04	114	88	5	PS50268
Domain	-	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.03e-04	114	88	5	2.60.40.60
Domain	CA	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.11e-04	115	88	5	SM00112
Domain	TIR_dom	TLR10 TLR1 IL18RAP	2.16e-04	25	88	3	IPR000157
Domain	Toll-like_receptor	TLR10 TLR1	2.17e-04	5	88	2	IPR017241
Domain	Cadherin-like	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.20e-04	116	88	5	IPR015919
Domain	Cadherin	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.38e-04	118	88	5	IPR002126
Domain	LRR_1	TLR10 LINGO1 MFHAS1 TLR1 FBXL14 ADGRA3	5.91e-04	219	88	6	PF00560
Domain	-	LRP6 LRP5 TENM2	8.17e-04	39	88	3	2.120.10.30
Domain	Cys-rich_flank_reg_C	TLR10 LINGO1 TLR1 ADGRA3	8.63e-04	90	88	4	IPR000483
Domain	LRRCT	TLR10 LINGO1 TLR1 ADGRA3	8.63e-04	90	88	4	SM00082
Domain	LRR_8	TLR10 LINGO1 MFHAS1 TLR1 ADGRA3	1.29e-03	171	88	5	PF13855
Domain	6-blade_b-propeller_TolB-like	LRP6 LRP5 TENM2	1.33e-03	46	88	3	IPR011042
Domain	Ran_BP1	RANBP3L RGPD1	1.40e-03	12	88	2	PF00638
Domain	RANBD1	RANBP3L RGPD1	1.40e-03	12	88	2	PS50196
Domain	ABC_tran	ABCA13 ABCB6 ABCG2	1.50e-03	48	88	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA13 ABCB6 ABCG2	1.50e-03	48	88	3	PS50893
Domain	Leu-rich_rpt_typical-subtyp	TLR10 LINGO1 MFHAS1 TLR1 ADGRA3	1.50e-03	177	88	5	IPR003591
Domain	LRR_TYP	TLR10 LINGO1 MFHAS1 TLR1 ADGRA3	1.50e-03	177	88	5	SM00369
Domain	ABC_TRANSPORTER_1	ABCA13 ABCB6 ABCG2	1.59e-03	49	88	3	PS00211
Domain	RanBD	RANBP3L RGPD1	1.66e-03	13	88	2	SM00160
Domain	Ran_bind_dom	RANBP3L RGPD1	1.66e-03	13	88	2	IPR000156
Domain	ABC_transporter-like	ABCA13 ABCB6 ABCG2	1.69e-03	50	88	3	IPR003439
Domain	Leu-rich_rpt	TLR10 LINGO1 MFHAS1 TLR1 FBXL14 ADGRA3	1.77e-03	271	88	6	IPR001611
Domain	Ldl_recept_b	LRP6 LRP5	1.93e-03	14	88	2	PF00058
Domain	LDLRB	LRP6 LRP5	1.93e-03	14	88	2	PS51120
Domain	LY	LRP6 LRP5	2.21e-03	15	88	2	SM00135
Domain	LDLR_classB_rpt	LRP6 LRP5	2.21e-03	15	88	2	IPR000033
Domain	LRR	TLR10 LINGO1 MFHAS1 TLR1 ADGRA3	2.61e-03	201	88	5	PS51450
Domain	ConA-like_dom	TRIM69 CNTNAP5 NBEAL1 MDGA2 ADGRV1	3.77e-03	219	88	5	IPR013320
Domain	-	TLR10 LINGO1 MFHAS1 TLR1 FBXL14 ADGRA3	4.10e-03	321	88	6	3.80.10.10
Domain	FA58C	CNTNAP5 F5	4.35e-03	21	88	2	SM00231
Domain	FA58C_3	CNTNAP5 F5	4.35e-03	21	88	2	PS50022
Domain	FA58C_1	CNTNAP5 F5	4.35e-03	21	88	2	PS01285
Domain	FA58C_2	CNTNAP5 F5	4.35e-03	21	88	2	PS01286
Domain	L_dom-like	TLR10 LINGO1 MFHAS1 TLR1 FBXL14 ADGRA3	4.55e-03	328	88	6	IPR032675
Domain	-	CNTNAP5 GUSB F5	4.96e-03	73	88	3	2.60.120.260
Domain	EGF_3	CNTNAP5 LRP6 LRP5 ASTN2 TENM2	5.08e-03	235	88	5	PS50026
Domain	F5_F8_type_C	CNTNAP5 F5	5.66e-03	24	88	2	PF00754
Domain	FA58C	CNTNAP5 F5	5.66e-03	24	88	2	IPR000421
Domain	JmjC	PHF2 KDM4B	5.66e-03	24	88	2	PF02373
Domain	TAS2R	TAS2R42 TAS2R41	6.63e-03	26	88	2	PF05296
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	TLR10 CYP1A1 EHMT2 TLR1 APAF1 ACCS GPAM ABCG2 IL4	3.71e-07	351	91	9	20453000
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.00e-06	68	91	5	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.34e-06	72	91	5	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.53e-06	74	91	5	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	1.87e-06	77	91	5	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.26e-06	80	91	5	10716726
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	6.77e-06	2	91	2	21887268
Pubmed	Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population.	TLR10 TLR1	6.77e-06	2	91	2	25687912
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	6.77e-06	2	91	2	33136328
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	6.77e-06	2	91	2	15084453
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	6.77e-06	2	91	2	33164872
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	6.77e-06	2	91	2	25902418
Pubmed	The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells.	PHF2 IL4	6.77e-06	2	91	2	38241965
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	6.77e-06	2	91	2	30474181
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	6.77e-06	2	91	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	6.77e-06	2	91	2	25783012
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	6.77e-06	2	91	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	6.77e-06	2	91	2	15537447
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	6.77e-06	2	91	2	17335347
Pubmed	Toll-like receptor 1 and 10 gene polymorphisms are linked to postbronchiolitis asthma in adolescence.	TLR10 TLR1	6.77e-06	2	91	2	28692144
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	6.77e-06	2	91	2	19503830
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	6.77e-06	2	91	2	37202775
Pubmed	Molecular analysis of immunized Jr(a-) or Lan- patients and validation of a high-throughput genotyping assay to screen blood donors for Jr(a-) and Lan- phenotypes.	ABCB6 ABCG2	6.77e-06	2	91	2	24456066
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	6.77e-06	2	91	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	6.77e-06	2	91	2	16355283
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	6.77e-06	2	91	2	28425175
Pubmed	Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.	TLR10 TLR1	6.77e-06	2	91	2	28368946
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	6.77e-06	2	91	2	18350154
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	6.77e-06	2	91	2	33118644
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	6.77e-06	2	91	2	18493104
Pubmed	IL16 and factor V gene variations are associated with asparaginase-related thrombosis in childhood acute lymphoblastic leukemia patients.	IL16 F5	6.77e-06	2	91	2	36946317
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	6.77e-06	2	91	2	30668923
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	6.77e-06	2	91	2	22433869
Pubmed	Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.	TLR10 TLR1	6.77e-06	2	91	2	26559190
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	6.77e-06	2	91	2	25802278
Pubmed	Toll-like receptor 1 and 10 variations increase asthma risk and review highlights further research directions.	TLR10 TLR1	6.77e-06	2	91	2	30924193
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	6.77e-06	2	91	2	33545636
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	6.77e-06	2	91	2	12579474
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA12 PCDHGA6 PCDHGA3	7.71e-06	15	91	3	23515096
Pubmed	Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.	CYP1A1 ABCG2 GCKR	1.37e-05	18	91	3	25288136
Pubmed	Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.	LPAR3 ABCG2 GCKR	1.63e-05	19	91	3	23118302
Pubmed	Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.	LRP6 LRP5	2.03e-05	3	91	2	24412065
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR10 TLR1	2.03e-05	3	91	2	18752252
Pubmed	Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.	LRP6 LRP5	2.03e-05	3	91	2	18524778
Pubmed	Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.	LRP6 LRP5	2.03e-05	3	91	2	25710911
Pubmed	Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.	LRP6 LRP5	2.03e-05	3	91	2	27803037
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR10 TLR1	2.03e-05	3	91	2	22150367
Pubmed	Association of interleukin-13/-4 and toll-like receptor 10 with preterm births.	TLR10 IL4	2.03e-05	3	91	2	19332998
Pubmed	Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.	LRP6 LRP5	2.03e-05	3	91	2	18406176
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR10 TLR1	2.03e-05	3	91	2	15812078
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR10 TLR1	2.03e-05	3	91	2	28123183
Pubmed	Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.	LRP6 LRP5	2.03e-05	3	91	2	21866564
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR10 TLR1	2.03e-05	3	91	2	17932345
Pubmed	Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.	LRP6 LRP5	2.03e-05	3	91	2	29602775
Pubmed	LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.	LRP6 LRP5	2.03e-05	3	91	2	18721193
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP6 LRP5	2.03e-05	3	91	2	23925701
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR10 TLR1	2.03e-05	3	91	2	25028161
Pubmed	The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.	LRP6 LRP5	2.03e-05	3	91	2	22589387
Pubmed	Integrating disease and drug-related phenotypes for improved identification of pharmacogenomic variants.	ABCG2 IL18RAP	2.03e-05	3	91	2	33769074
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR10 TLR1	2.03e-05	3	91	2	25850295
Pubmed	Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.	LRP6 LRP5	2.03e-05	3	91	2	25959626
Pubmed	The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.	ABCB6 ABCG2	2.03e-05	3	91	2	27507172
Pubmed	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	LRP6 LRP5	2.03e-05	3	91	2	21397183
Pubmed	Association between the polymorphisms of IL-4 gene promoter (-590C>T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T>C) and allergic asthma.	IL16 IL4	2.03e-05	3	91	2	17303923
Pubmed	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.	LRP6 LRP5	2.03e-05	3	91	2	22000856
Pubmed	Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.	LRP6 LRP5	2.03e-05	3	91	2	24743782
Pubmed	Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.	LRP6 LRP5	2.03e-05	3	91	2	33650028
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR10 TLR1	2.03e-05	3	91	2	18091991
Pubmed	[Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like dermatitis induced by trichloroethylene].	CYP1A1 IL4	2.03e-05	3	91	2	19351467
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR10 TLR1	2.03e-05	3	91	2	23151486
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	LRP6 LRP5	2.03e-05	3	91	2	30664649
Pubmed	Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.	LRP6 LRP5	2.03e-05	3	91	2	22576936
Pubmed	Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.	LRP6 LRP5	2.03e-05	3	91	2	25009587
Pubmed	TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.	LRP6 LRP5	2.03e-05	3	91	2	33065966
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PHF2 SYNE1 APAF1 ADGRV1 UNC80 KDM4B	2.89e-05	225	91	6	12168954
Pubmed	Toll-like receptor heterodimer variants protect from childhood asthma.	TLR10 TLR1	4.05e-05	4	91	2	18547625
Pubmed	Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.	LRP6 LRP5	4.05e-05	4	91	2	26772978
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	LRP6 LRP5	4.05e-05	4	91	2	29176883
Pubmed	Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.	LRP6 LRP5	4.05e-05	4	91	2	18502762
Pubmed	IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn's disease patients.	IL16 IL4	4.05e-05	4	91	2	17576577
Pubmed	Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.	TLR10 TLR1	4.05e-05	4	91	2	20815312
Pubmed	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	TLR10 TLR1	4.05e-05	4	91	2	20348427
Pubmed	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.	LRP6 LRP5	4.05e-05	4	91	2	15908424
Pubmed	Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.	LRP6 LRP5	4.05e-05	4	91	2	23675479
Pubmed	Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.	LRP6 LRP5	4.05e-05	4	91	2	31452509
Pubmed	Critical Endothelial Regulation by LRP5 during Retinal Vascular Development.	LRP6 LRP5	4.05e-05	4	91	2	27031698
Pubmed	Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.	LRP6 LRP5	4.05e-05	4	91	2	22696217
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP6 LRP5	4.05e-05	4	91	2	21471202
Pubmed	Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study.	TLR10 TLR1	4.05e-05	4	91	2	29566186
Pubmed	The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.	LRP6 LRP5	4.05e-05	4	91	2	32917787
Pubmed	Associations between toll-like receptors and interleukin-4 in the lungs of patients with tuberculosis.	TLR1 IL4	4.05e-05	4	91	2	12600829
Pubmed	Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.	LRP6 LRP5	4.05e-05	4	91	2	17002572
Pubmed	Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.	LRP6 LRP5	4.05e-05	4	91	2	30361437
Pubmed	Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.	LRP6 LRP5	4.05e-05	4	91	2	15064719
Pubmed	Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.	LRP6 LRP5	4.05e-05	4	91	2	20846389
Pubmed	Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.	LRP6 LRP5	4.05e-05	4	91	2	11433302
Pubmed	Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.	TMEM67 SYNE1	4.05e-05	4	91	2	19596800
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP6 LRP5	4.05e-05	4	91	2	30325689
Pubmed	Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol.	TAS2R42 TAS2R41	4.05e-05	4	91	2	23632330
Pubmed	Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.	LRP6 LRP5	4.05e-05	4	91	2	18762581
Interaction	NMS interactions	LRP6 LRP5 ADGRV1 EDEM1	8.92e-06	30	89	4	int:NMS
Interaction	PCDHGA4 interactions	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA8	1.49e-05	34	89	4	int:PCDHGA4
Interaction	ECEL1 interactions	TLR10 GUSB LRP6 KIF14 TOR3A DIPK2A	2.86e-05	134	89	6	int:ECEL1
Interaction	ST8SIA4 interactions	TMEM67 ST8SIA2 LRP6 LRP5 ADGRV1	3.52e-05	84	89	5	int:ST8SIA4
Interaction	PRSS37 interactions	LRP6 LRP5 ADGRV1	3.65e-05	15	89	3	int:PRSS37
Interaction	NPIPB6 interactions	RGPD1 KIF14 KPNA2	6.48e-05	18	89	3	int:NPIPB6
Cytoband	5q31	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	3.54e-06	115	91	5	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8 IL4	2.98e-05	298	91	6	chr5q31
Cytoband	6q25	SYNE1 ULBP3	2.53e-04	12	91	2	6q25
GeneFamily	Clustered protocadherins	PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	2.84e-06	64	63	5	20
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	ABCB6 KEL ABCG2	2.88e-04	37	63	3	454
GeneFamily	CD molecules\|Toll like receptors	TLR10 TLR1	5.28e-04	10	63	2	948
GeneFamily	Low density lipoprotein receptors	LRP6 LRP5	9.09e-04	13	63	2	634
GeneFamily	Beta 4-glycosyltransferases	B4GALNT2 CHSY3	1.57e-03	17	63	2	425
GeneFamily	WD repeat domain containing	WDR11 WDR7 NBEAL1 APAF1 DMXL1	2.18e-03	262	63	5	362
GeneFamily	PHD finger proteins\|Lysine demethylases	PHF2 KDM4B	3.14e-03	24	63	2	485
GeneFamily	Taste 2 receptors	TAS2R42 TAS2R41	8.15e-03	39	63	2	1162
GeneFamily	Endogenous ligands\|Interleukins	IL16 IL4	9.84e-03	43	63	2	601
GeneFamily	Ankyrin repeat domain containing	TANC2 ANKRD29 ANKRD35 EHMT2	1.01e-02	242	63	4	403
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	TLR10 TLR1 KEL ABCG2 IL18RAP	1.20e-02	394	63	5	471
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ABCA13 MFHAS1 SYNE1 ASTN2 LIX1 ADGRA3	1.48e-07	194	91	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LPAR3 RANBP3L CYP2J2 SYNE1 GPAM ADGRV1 CYFIP2	1.82e-07	200	91	7	d0812817ef99608994193787a62d39adeb2070ca
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LPAR3 RANBP3L CYP2J2 SYNE1 GPAM ADGRV1 CYFIP2	1.82e-07	200	91	7	cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP5 ABCA13 BEST2 MDGA2 ADGRV1 UNC80	5.37e-07	145	91	6	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNTNAP5 ABCA13 MDGA2 ADGRV1 F5 UNC80	1.03e-06	162	91	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ABCA13 MFHAS1 SYNE1 ASTN2 LIX1	2.59e-06	190	91	6	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 MFHAS1 SYNE1 ASTN2 LIX1 ADGRA3	2.84e-06	193	91	6	f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 MFHAS1 SYNE1 ASTN2 LIX1 ADGRA3	2.84e-06	193	91	6	42df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP5 SYNE1 MDGA2 CHSY3 TENM2 UNC80	3.29e-06	198	91	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TANC2 CNTNAP5 SYNE1 LRP6 UNC80 CYFIP2	3.39e-06	199	91	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANKRD29 RANBP3L CYP2J2 SYNE1 GPAM ADGRV1	3.48e-06	200	91	6	7a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LPAR3 RANBP3L SYNE1 GPAM ADGRV1 CYFIP2	3.48e-06	200	91	6	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SETX SYNE1 APOL6 IL18RAP CYFIP2 PSD4	3.48e-06	200	91	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Rgs14_(CA2_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	IL16 B4GALNT2 KEL IL18RAP	1.09e-05	67	91	4	771fc7c4917b5dc5ebf1b7be304d62902f0b75cc
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Rgs14_(CA2_Principal_cells)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	IL16 B4GALNT2 KEL IL18RAP	1.09e-05	67	91	4	f56d8787ab2170997d28a2f66d83b4c18362b97d
ToppCell	COVID-19-Myeloid-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	TLR10 ACSL1 TLR1 APAF1 DIRC1	1.72e-05	156	91	5	a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKRD29 CNTNAP5 ST8SIA2 ADGRA3 DIPK2A	2.25e-05	165	91	5	d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCell	Adult-Epithelial-club_cell-D175\|Adult / Lineage, Cell type, age group and donor	CYP2J2 LRP5 SIX4 LIX1 ADGRA3	3.15e-05	177	91	5	d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UBTD1 CHSY3 ADGRV1 RNF145 ADGRA3	3.24e-05	178	91	5	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL1 LINGO1 RANBP3L ADGRV1 CYFIP2	3.41e-05	180	91	5	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL1 LINGO1 RANBP3L ADGRV1 CYFIP2	3.41e-05	180	91	5	a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 ABCA13 SYNE1 KIF14 F5	3.50e-05	181	91	5	566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 ABCA13 SYNE1 KIF14 F5	3.50e-05	181	91	5	db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 ABCB6 GPAM F5 ADGRA3	3.69e-05	183	91	5	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF14 MDGA2 ADGRV1 LINC01356 KPNA2	3.69e-05	183	91	5	29b62dd542bc3f8df843998f577724f3818d4271
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 DISP3 MDGA2 ADGRV1 UNC80	3.79e-05	184	91	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 RANBP3L MFHAS1 ASTN2 RNF145	3.79e-05	184	91	5	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 DISP3 MDGA2 ADGRV1 UNC80	3.79e-05	184	91	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA13 DISP3 MDGA2 ADGRV1 UNC80	3.79e-05	184	91	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACSL1 UBTD1 RANBP3L SLC39A13 CYFIP2	3.89e-05	185	91	5	d1cfca6e85fa767253de7e8a14621989b816635f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 ABCA13 MFHAS1 ASTN2 ADGRV1	4.20e-05	188	91	5	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 RANBP3L MFHAS1 ASTN2 ADGRV1	4.31e-05	189	91	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	LINGO1 RANBP3L SYNE1 ASTN2 CYFIP2	4.31e-05	189	91	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 RANBP3L MFHAS1 ASTN2 ADGRV1	4.41e-05	190	91	5	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TANC2 RANBP3L MFHAS1 ASTN2 ADGRV1	4.41e-05	190	91	5	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACSL1 ABCA13 SYNE1 RNF145 UNC80	4.53e-05	191	91	5	d4f77c73311d1149466bbfe4adbd6a301946ec90
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP1A1 CYP2J2 LRP5 SIX4 RNF145	4.87e-05	194	91	5	0cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP1A1 CYP2J2 LRP5 SIX4 RNF145	4.87e-05	194	91	5	a58841b34efe673671a9a059238e044a7254b279
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TANC2 UBTD1 SYNE1 ADGRV1 RNF145	4.87e-05	194	91	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACSL1 ABCA13 ADGRV1 F5 UNC80	4.99e-05	195	91	5	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ACSL1 ABCA13 ADGRV1 F5 UNC80	4.99e-05	195	91	5	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 MDGA2 CHSY3 TENM2 UNC80	5.12e-05	196	91	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP5 SYNE1 MDGA2 TENM2 UNC80	5.37e-05	198	91	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TANC2 LIPE GPAM ADGRV1 CYFIP2	5.37e-05	198	91	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP5 SYNE1 MDGA2 TENM2 UNC80	5.37e-05	198	91	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CNTNAP5 SYNE1 MDGA2 UNC80 CYFIP2	5.50e-05	199	91	5	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CNTNAP5 SYNE1 MDGA2 UNC80 CYFIP2	5.50e-05	199	91	5	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L SYNE1 GPAM ADGRV1 TENM2	5.63e-05	200	91	5	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L SYNE1 GPAM ADGRV1 TENM2	5.63e-05	200	91	5	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SYNE1 MDGA2 CHSY3 TENM2 UNC80	5.63e-05	200	91	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ACSL1 LRP6 ASTN2 ADGRV1 UNC80	5.63e-05	200	91	5	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L SYNE1 GPAM ADGRV1 TENM2	5.63e-05	200	91	5	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	Macroglial-Astrocytes-GFAP---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L ADGRV1 TENM2 LIX1 ADGRA3	5.63e-05	200	91	5	88d66550781a3c9102ff7455f5cff6fb072943cd
ToppCell	Macroglial-Astrocytes-GFAP-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L ADGRV1 TENM2 LIX1 ADGRA3	5.63e-05	200	91	5	d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCell	Macroglial-Astrocytes-GFAP--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L ADGRV1 TENM2 LIX1 ADGRA3	5.63e-05	200	91	5	16269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCell	Macroglial-Astrocytes-GFAP----L1-2\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L ADGRV1 TENM2 LIX1 ADGRA3	5.63e-05	200	91	5	c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L SYNE1 GPAM ADGRV1 TENM2	5.63e-05	200	91	5	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Macroglial-Astrocytes-GFAP\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L ADGRV1 TENM2 LIX1 ADGRA3	5.63e-05	200	91	5	79634b1086934412ae92f259ab43554ce545008f
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	RANBP3L SYNE1 GPAM ADGRV1 TENM2	5.63e-05	200	91	5	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR7 TLR1 F5 BCDIN3D	9.43e-05	116	91	4	f2bf9599040f43b5ea8724841d7b71c0a859c016
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D231\|Adult / Lineage, Cell type, age group and donor	CYP2J2 DISP3 KEL ADGRV1	1.55e-04	132	91	4	8d30b71776f5f6da55dc78e0c5cb27be460004e3
Drug	CAS 79350-37-1	GUSB SYNE1 ST8SIA2 KEL	2.83e-06	25	91	4	CID000002675
Drug	AC1L1B2H	GUSB FBXL14 KEL	7.26e-06	10	91	3	CID000001255
Drug	atazanavir	WDR11 GUSB KEL ABCG2 IL18RAP IL4	8.74e-06	120	91	6	CID000148192
Drug	Cimetidine	CYP1A1 IL16 CYP2J2 APAF1 ABCG2	1.35e-05	76	91	5	ctd:D002927
Drug	ICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A	APAF1 APOL6 LRP5 ADCK2 F5 KDM4B PSD4	1.48e-05	198	91	7	6197_DN
Drug	CID9959010	PCDHGA12 PCDHGA3 B4GALNT2 PCDHGA8	1.76e-05	39	91	4	CID009959010
Drug	furafylline	CYP1A1 FMO3 CYP2J2 GUSB	2.16e-05	41	91	4	CID000003433
Disease	childhood trauma measurement, alcohol consumption measurement	TANC2 PCDHGA12 PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	6.77e-08	71	87	6	EFO_0007878, EFO_0007979
Disease	Sarcosine measurement	PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	5.98e-07	23	87	4	EFO_0021668
Disease	mental development measurement	PCDHGA6 PCDHGA3 PCDHGA1 PCDHGA8	8.50e-07	25	87	4	EFO_0008230
Disease	coffee consumption measurement, tea consumption measurement	CYP1A1 LINGO1 ABCG2 GCKR	8.74e-06	44	87	4	EFO_0006781, EFO_0010091
Disease	coffee consumption, cups of coffee per day measurement	CYP1A1 ABCG2 GCKR	1.35e-05	16	87	3	EFO_0004330, EFO_0006782
Disease	anti-Helicobacter pylori serum IgG measurement	TLR10 TLR1	2.57e-05	3	87	2	EFO_0005247
Disease	amino acid measurement	TANC2 LPAR3 UBTD1 SETX CYP2J2 SYNE1 ASTN2 ABCG2 GCKR DIPK2A	3.13e-05	678	87	10	EFO_0005134
Disease	urate measurement, bone density	LPAR3 CNTNAP5 LINGO1 WDR7 EHMT2 SYNE1 ST8SIA2 KIF14 TENM2	8.89e-05	619	87	9	EFO_0003923, EFO_0004531
Disease	Cleft palate, cleft lip	TANC2 PHF2 ABCA13 MTMR3 MDGA2 TENM2	1.80e-04	279	87	6	EFO_0003959, HP_0000175
Disease	lipoprotein-associated phospholipase A(2) measurement	LPAR3 ABCG2 GCKR	2.26e-04	40	87	3	EFO_0004746
Disease	cups of coffee per day measurement	CYP1A1 ABCG2 GCKR	2.26e-04	40	87	3	EFO_0006782
Disease	end stage renal disease (is_implicated_in)	CYP1A1 GCKR F5	2.43e-04	41	87	3	DOID:783 (is_implicated_in)
Disease	bitter beverage consumption measurement	CYP1A1 ABCG2 GCKR	2.62e-04	42	87	3	EFO_0010089
Disease	Malignant neoplasm of breast	ANKRD29 CYP1A1 LIPE SYNE1 MTMR3 MED14 ACCS ABCB6 ASTN2 ABCG2 SIX4	3.15e-04	1074	87	11	C0006142
Disease	alopecia areata (is_marker_for)	EHMT2 KDM4B	3.81e-04	10	87	2	DOID:986 (is_marker_for)
Disease	alcohol use disorder measurement	WDR11 GCKR TENM2 SLC39A13 KDM4B	4.37e-04	214	87	5	EFO_0009458
Disease	level of Diacylglycerol (18:1_18:1) in blood serum	B4GALNT2 GCKR	4.65e-04	11	87	2	OBA_2045170
Disease	paraxanthine measurement	CYP1A1 ABCG2	5.56e-04	12	87	2	EFO_0021178
Disease	Chromosome Breakage	EHMT2 IL4	7.64e-04	14	87	2	C0376628
Disease	Chromosome Breaks	EHMT2 IL4	7.64e-04	14	87	2	C0333704
Disease	Allergic Reaction	CYP1A1 IL16 IL4	8.65e-04	63	87	3	C1527304
Disease	Hypersensitivity	CYP1A1 IL16 IL4	9.06e-04	64	87	3	C0020517
Disease	Polyposis, Adenomatous Intestinal	FMO3 F5	1.00e-03	16	87	2	C2713442
Disease	Familial Intestinal Polyposis	FMO3 F5	1.00e-03	16	87	2	C2713443
Disease	vital capacity	CYP1A1 GUSB SYNE1 MTMR3 LRP6 ASTN2 CHSY3 SIX4 TENM2 VWA5B1 KDM4B	1.01e-03	1236	87	11	EFO_0004312
Disease	Adenomatous Polyposis Coli	FMO3 F5	1.14e-03	17	87	2	C0032580
Disease	body weight	LINGO1 NBEAL1 GUSB RGPD1 MTMR3 ASTN2 MDGA2 GCKR ADGRV1 BCDIN3D KDM4B	1.19e-03	1261	87	11	EFO_0004338
Disease	asthma (is_implicated_in)	TLR10 IL16 TLR1 IL4	1.22e-03	157	87	4	DOID:2841 (is_implicated_in)
Disease	Meckel syndrome type 1	TMEM67 KIF14	1.28e-03	18	87	2	C3714506
Disease	leucine measurement	WDR7 ABCG2 GCKR	1.33e-03	73	87	3	EFO_0009770
Disease	caffeine metabolite measurement	CYP1A1 GCKR	1.42e-03	19	87	2	EFO_0007872
Disease	chronic myeloid leukemia (is_implicated_in)	CYP1A1 ABCG2	1.74e-03	21	87	2	DOID:8552 (is_implicated_in)
Disease	saturated fatty acids to total fatty acids percentage	GPAM GCKR	1.74e-03	21	87	2	EFO_0022305
Disease	prothrombin time measurement	GCKR F5	1.74e-03	21	87	2	EFO_0008390
Disease	alcohol drinking	LINGO1 TLR1 GCKR	1.79e-03	81	87	3	EFO_0004329
Disease	alcoholic liver disease	CNTNAP5 ABCG2 ADGRA3	1.85e-03	82	87	3	EFO_0008573
Disease	blood pressure	CNTNAP5 SYNE1	1.91e-03	22	87	2	EFO_0004325
Disease	Morbilliform Drug Reaction	CYP1A1 IL4	2.09e-03	23	87	2	C0406537
Disease	Drug Eruptions	CYP1A1 IL4	2.09e-03	23	87	2	C0011609
Disease	nephrotic syndrome (biomarker_via_orthology)	GPAM IL4	2.27e-03	24	87	2	DOID:1184 (biomarker_via_orthology)
Disease	digestive system infectious disorder	ANKRD29 MFHAS1	2.67e-03	26	87	2	MONDO_0043424
Disease	health study participation	PHF2 LINGO1 TENM2 KDM4B	2.68e-03	195	87	4	EFO_0010130
Disease	body surface area	GUSB RGPD1 MTMR3 ASTN2 GCKR SLC39A13 PSD4	2.93e-03	643	87	7	EFO_0022196

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLLKNSRLLSWSFDG	APAF1	1051	O14727
NARFGGFSQLLLLWR	BEST2	11	Q8NFU1
IKLGQWASTRRDLFS	ADCK2	146	Q7Z695
LKSQFGSWGRNRRDL	DISP3	126	Q9P2K9
RKRLSKGFWSLLFSN	C8orf44	141	Q96CB5
GQAWKEQRRFTLTAL	CYP2J2	131	P51589
NKLCFDLLSWRLSQR	ACCS	106	Q96QU6
LWRRFLDNKVLLSFG	ACCS	431	Q96QU6
SRRQGSRFLWLLKIL	B4GALNT2	61	Q8NHY0
RAFWKLRANPRLANA	APOL6	186	Q9BWW8
RIFGQANTTLKRWLL	ACSL1	376	P33121
GNTSWDRSLLLFRAK	BCDIN3D	251	Q7Z5W3
WGLSSLKRLDLTNNR	ADGRA3	126	Q8IWK6
QLRWVSKRSFKNLLG	ABCG2	376	Q9UNQ0
ANARLNSLLFRWSGS	ADGRV1	3426	Q8WXG9
AFWAARRGNLALLKL	ANKRD29	16	Q8N6D5
SRIALWRKGLLFNNS	ABCA13	2821	Q86UQ4
QSTWRDFGRKLRLLS	ABCB6	236	Q9NP58
DVWFALQLNRKLRLG	EHMT2	896	Q96KQ7
RKLLASQSSGLRGLW	ANKRD35	691	Q8N283
RWRKAALKNAFSLLG	DMXL1	1676	Q9Y485
KILRSTFSLGQGLWL	ASTN2	581	O75129
LLGWTGSKLFQRELR	POLM	431	Q9NP87
QLSRKFWGSSKRLSQ	NBEAL1	2666	Q6ZS30
WAARRRLAQNGLKSF	CYP1A1	131	P04798
RDSGQNAWLSYRLLK	PCDHGA8	596	Q9Y5G5
RDSGQNAWLSYRLLK	PCDHGA12	596	O60330
SYLRQKLQALGLRWG	FASTK	531	Q14296
RVRNLKLGISTFWSL	KIF14	1126	Q15058
RDSGQNAWLSYRLLK	PCDHGA6	596	Q9Y5G7
QLRITSRIFQWKGLS	IL18RAP	571	O95256
GARNAILTQWDRSLK	FMO3	481	P31513
SGNLKTARLWRDAAL	MFHAS1	6	Q9Y4C4
NLNGTSRKVLFWQDL	LRP5	136	O75197
GAAQAFSKRTLSWRL	MMP21	166	Q8N119
WFRQSLKGLRNRASD	IL16	791	Q14005
ALRPLLSLQWKNRAA	KDM4B	651	O94953
RWFLRQGLLDSSLTA	LPAR3	101	Q9UBY5
VSNLDGSLRKVLFWQ	LRP6	121	O75581
LVLLFLWSRGKGNTK	LINGO1	576	Q96FE5
RQFWSSVKLLGNFLQ	PAXBP1	771	Q9Y5B6
DLALRGLQLLSKWSA	CYFIP2	391	Q96F07
WGLQRLKSLNLRSCR	FBXL14	166	Q8N1E6
IFQLLHWNGSLKALR	LIX1	166	Q8N485
WRLGNKLLRTGQFDS	MDGA2	576	Q7Z553
FVRLLALVKWANNAG	MED14	96	O60244
LDLRISNSKLFWRAL	GCKR	506	Q14397
LRNLTWTLSNLCRNK	KPNA2	226	P52292
RDSGQNAWLSYRLLK	PCDHGA3	596	Q9Y5H0
FLKRLDRNLWGLAGL	IL4	106	P05112
AWGRLRLLDFLNVKN	DIPK2A	76	Q8NDZ4
LVKDFNLLRWLGANA	GUSB	366	P08236
RAVKALWNLRSNDTG	EDEM1	331	Q92611
LNTVRLKCLNSLRGW	DIRC1	81	Q969H9
RAGFDRWSAAKLQLS	SLC39A13	271	Q96H72
VSFQFRTWNKDGLLL	CNTNAP5	391	Q8WYK1
LLRDFRLGASSWLNS	LIPE	816	Q05469
VWSLLRAGNKAFKNL	MTMR3	536	Q13615
FNTDRLAWTRNKLRG	RGPD1	6	P0DJD0
RDSGQNAWLSYRLLK	PCDHGA1	596	Q9Y5H4
SNSGKWLLTRRIFLV	TMEM67	431	Q5HYA8
RSVFSQLLLLARGFW	TAS2R41	291	P59536
LGNSKLRQTAVRLLW	TAS2R42	286	Q7RTR8
NKLWNATKFALRGLG	VARS1	951	P26640
ILNGAFRSWTKKQAL	PHF2	401	O75151
NRLKSVTWYLLAGLR	TLR10	106	Q9BXR5
SRDLKQQLLLLNGRW	SYNE1	676	Q8NF91
KTWNQSIALRLELFG	F5	2206	P12259
LGPNLKAWLRVFSRN	PIGF	131	Q07326
IRLTGWVLLKLFNSF	GPAM	186	Q9HCL2
GVRNNKVAWNLASRL	PSD4	581	Q8NDX1
GLSLTQVSNWFKNRR	SIX4	261	Q9UIU6
KLNLFLRGNLSLGWQ	SETX	561	Q7Z333
TWREKLLQRLHSLNG	ST8SIA2	221	Q92186
TLLAFWFSRQEGKLN	TANC2	791	Q9HCD6
LDQARQRALGTAWAK	TENM2	2696	Q9NT68
GLFWANLRAAINIKL	TLR1	766	Q15399
QKYLGSRALAAQRTW	CHSY3	181	Q70JA7
QGFWLLRLRNQTDLK	TRIM69	411	Q86WT6
GRKFLLFDSNNRKWT	ULBP3	146	Q9BZM4
RNWLKRSSLSGLADG	UNC80	1086	Q8N2C7
QGSLRLILNSKLWAQ	RANBP3L	346	Q86VV4
WFFSGKLLTDRTRLQ	UBTD1	191	Q9HAC8
GQASRWLFLFLFQKL	LINC01356	91	Q8N9X3
QLRAAGALSKRYWTL	TOR3A	51	Q9H497
NLNFWDLKGRVSRGI	WDR11	731	Q9BZH6
RAQLGWKSFLLRRDA	RNF145	501	Q96MT1
KGITSGRAQLLWFLQ	TMEM254	86	Q8TBM7
NALKLARLIWTSNRN	WDR7	1461	Q9Y4E6
GIQKLRNVLLAFSWR	TBC1D2B	731	Q9UPU7
SENLFGSWLNLNKSR	VWA5B1	1006	Q5TIE3
GSWLNLNKSRLLTRA	VWA5B1	1011	Q5TIE3
ISGKWTSLNFNRTLR	KEL	181	P23276