Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells.	MLXIPL PDX1	3.55e-06	2	66	2	20934404
Pubmed	Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta.	CEBPB PDX1	3.55e-06	2	66	2	17705277
Pubmed	Insulin-like growth factor 2 mRNA-binding protein 2-regulated alternative splicing of nuclear factor 1 C-type causes excessive granulosa cell proliferation in polycystic ovary syndrome.	IGFBP2 NFIC	3.55e-06	2	66	2	35293050
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 ESRP2 LRFN1 ARSJ CEBPB OFD1 KALRN SHC1 SAC3D1 ANKRD33B ANO8	6.87e-06	1105	66	11	35748872
Pubmed	Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.	CEBPB DYRK1B	1.06e-05	3	66	2	36318489
Pubmed	Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.	SHC1 PLSCR1	1.06e-05	3	66	2	12009895
Pubmed	rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.	CEBPB NFIC	1.06e-05	3	66	2	38528526
Pubmed	PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions.	IGFBP2 INO80B	1.06e-05	3	66	2	19095771
Pubmed	Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.	SHC1 PLSCR1	2.12e-05	4	66	2	12871937
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	KIAA1671 TICRR FANCG ADAM15 DOK3 LEMD1 MAPK7 MGAT5B ANKRD33B	2.69e-05	832	66	9	36724073
Pubmed	Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes.	FANCG DOK3	3.53e-05	5	66	2	12627171
Pubmed	C/EBPalpha and C/EBPbeta are markers of early liver development.	CEBPB PDX1	3.53e-05	5	66	2	16892179
Pubmed	The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.	KALRN MAPK7	3.53e-05	5	66	2	22508986
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRFN1 LRRC4B ADGRA3	3.74e-05	34	66	3	18848646
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	KALRN KIF1B DOLK ZNF598 GPSM1	6.05e-05	218	66	5	33378226
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	FANCG PPFIBP2 DOLK PRKCSH MAPK7 ZNF688 ZNF446 PLSCR1	7.98e-05	742	66	8	26871637
Pubmed	Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN).	ZAN PDX1	9.86e-05	8	66	2	9126492
Pubmed	Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.	MLXIPL PDX1	1.27e-04	9	66	2	20534694
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	KIF1B MAPK8IP2	2.31e-04	12	66	2	16301330
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	LRFN1 KALRN LRRC4B ADGRA3	2.61e-04	162	66	4	25826454
Pubmed	Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.	MLXIPL TMEM120A	5.32e-04	18	66	2	25288136
Pubmed	Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.	HOXA10 PDX1	5.32e-04	18	66	2	9291463
Pubmed	Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.	CEBPB BATF3	7.99e-04	22	66	2	28566324
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	HOXA10 MLXIPL CEBPB NFIC DYRK1B ZNF446	8.38e-04	583	66	6	29844126
Pubmed	Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.	MLXIPL CEBPB	8.75e-04	23	66	2	27974211
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KALRN DYRK1B CCDC17 MAPK8IP2	1.02e-03	233	66	4	37704626
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF1B KIF12	1.03e-03	25	66	2	9275178
Pubmed	An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.	CEBPB BATF3	1.12e-03	26	66	2	33238123
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ESRP2 HOXA10 CEBPB NFIC PAXX BATF3 ZNF598	1.19e-03	857	66	7	25609649
Pubmed	Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.	HTR1B PDX1	1.21e-03	27	66	2	31806625
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	KIF1B ZNF598	1.21e-03	27	66	2	19026994
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 MLXIPL CARMIL2 OFD1 KIF1B DYRK1B ZNF598	1.22e-03	861	66	7	36931259
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	DOCK3 HTR1B	1.30e-03	28	66	2	19352218
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	KIAA1671 DOCK3 PRR14 MAP1A PPFIBP2	1.36e-03	430	66	5	35044719
Pubmed	High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.	MLXIPL PDX1	1.39e-03	29	66	2	34461288
Pubmed	Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes.	MLXIPL CEBPB	1.39e-03	29	66	2	38972757
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PRR14 AAAS CEBPB NFIC RC3H1	1.77e-03	457	66	5	32344865
Pubmed	Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.	CEBPB BATF3	1.80e-03	33	66	2	20102225
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRFN1 KALRN LRRC4B ADGRA3	6.23e-04	161	44	4	593
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF1B KIF12	5.60e-03	46	44	2	622
GeneFamily	Basic leucine zipper proteins	CEBPB BATF3	6.33e-03	49	44	2	506
GeneFamily	HOXL subclass homeoboxes	HOXA10 PDX1	7.10e-03	52	44	2	518
Coexpression	GSE43955_10H_VS_30H_ACT_CD4_TCELL_WITH_TGFB_IL6_DN	ESRP2 FANCG DYRK1B SHC1 PDX1 ANKRD33B	1.10e-05	199	66	6	M9697
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TICRR KALRN MAMSTR BATF3 MGAT5B	3.43e-06	155	66	5	59035d792c26d870a8b097939e97fa47859ba68c
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLXIPL ARSJ KIF12 SLC25A47 MAPK8IP2	6.92e-06	179	66	5	f2e8fc975c30992611630197b79daaeef7c4211d
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TICRR FANCG MMP21 SAC3D1 HUNK	1.10e-05	197	66	5	0a6754a5109bec0d0de42adbfdf4db43ff60c3d2
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHRR ARSJ IGFBP2 SHC1 ARID3C	1.16e-05	199	66	5	85bb28369e0568b7b3bda095722102fc793f60ef
Disease	glucose measurement	CEBPB ZAN PPFIBP2 PDX1 SLC25A47 GPSM1	1.91e-04	380	65	6	EFO_0004468
Disease	HSV2 virologic severity measurement	KIF1B MGAT5B	4.93e-04	15	65	2	EFO_0009010
Disease	HbA1c measurement	MLXIPL NFIC ADAM15 PDX1 SLC25A47 PRKCSH GPSM1	7.01e-04	675	65	7	EFO_0004541
Disease	attention deficit hyperactivity disorder (is_implicated_in)	DOCK3 HTR1B	8.85e-04	20	65	2	DOID:1094 (is_implicated_in)
Disease	fat intake measurement	MLXIPL MAMSTR	1.07e-03	22	65	2	EFO_0010809
Disease	brain cancer (implicated_via_orthology)	PROX2 GPSM1	1.50e-03	26	65	2	DOID:1319 (implicated_via_orthology)
Disease	familial hyperlipidemia	MLXIPL ATXN7L2 MAMSTR	1.67e-03	106	65	3	MONDO_0001336
Disease	testosterone measurement	DOCK3 MLXIPL ARSJ ZAN MAP1A DAAM2 SLC25A47 ARID3C PRRT1	1.85e-03	1275	65	9	EFO_0004908
Disease	cerebral infarction (is_implicated_in)	KALRN PDX1	1.87e-03	29	65	2	DOID:3526 (is_implicated_in)
Disease	colorectal adenocarcinoma (is_implicated_in)	DOK3 CCDC17	2.71e-03	35	65	2	DOID:0050861 (is_implicated_in)
Disease	parasitemia measurement	HTR1B HUNK	3.03e-03	37	65	2	EFO_0005528

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPPSLRPMPRGSCLP	AHRR	426	A9YTQ3
MEEPGAQCAPPPPAG	HTR1B	1	P28222
MCSLGLFPPPPPRGQ	AAAS	1	Q9NRG9
PPPPAPGPMGNCAIL	CCDC17	441	Q96LX7
PPPRKPLPADPQGRC	ADAM15	816	Q13444
PPRPCMPPSFLPRGK	ARID3C	331	A6NKF2
CQDPDEPPPPPRPML	ADGRA3	861	Q8IWK6
APGPPAGPLPRMDLP	CARMIL2	996	Q6F5E8
LCPMNFVPVPPRPDP	BATF3	106	Q9NR55
MTGGRPPLPPPDDPA	DYRK1B	596	Q9Y463
PGPTLRPACPASMPP	ATXN7L2	486	Q5T6C5
CMTPPPPSPPRGAQV	ANKRD33B	16	A6NCL7
AECPPCAMAGPPPAP	ANO8	1171	Q9HCE9
CAMAGPPPAPQPLPG	ANO8	1176	Q9HCE9
SIPPRGPADLPPMPV	RC3H1	556	Q5TC82
ASPSPCPDRMPLPSP	OFD1	761	O75665
MDPLSPPLCTLPPGP	PAXX	1	Q9BUH6
LLVSPPCAPPVMNGP	LEMD1	41	Q68G75
APPCLGMGLPLPQDP	DAAM2	571	Q86T65
SGDCAMESPPPAPPP	MAPK7	426	Q13164
PLPQGPPPLLPMSCS	HRG	311	P04196
PDPRPSPPRPDVCMA	MAP1A	2566	P78559
MTRECPSPAPGPGAP	DOLK	1	Q9UPQ8
GMEGPPPPDACPEKR	KIAA1671	1611	Q9BY89
CPPPDVLPRGPTMPD	GPSM1	616	Q86YR5
LMTPAACPEPPPEAP	PRKCSH	506	P14314
GLTPPCPCLMAPAPP	KIF12	476	Q96FN5
SPPQPCRRFFPPPMP	KIF1B	1211	O60333
CVVPLPLMAPPPAAP	LRFN1	386	Q9P244
MAPRGCAGHPPPPSP	ARSJ	1	Q5FYB0
METLCAPPPPAPAAP	MAPK8IP2	411	Q13387
VPPGRGSCPLTMPLP	MGAT5B	346	Q3V5L5
SPPACLYMGRQPPPP	PDX1	31	P52945
MPAPQPPLNCPPGLE	PLSCR1	86	O15162
MLPRVGCPALPLPPP	IGFBP2	1	P18065
RCGVPDMRPPPPSAP	MMP21	116	Q8N119
PAGCLNEGMAPPTPP	KALRN	1901	O60229
TPGELREMPPGPEPP	DOK3	336	Q7L591
RFSPPPSPPGPCMPE	FANCG	381	O15287
APRSCRMEPPDGPPP	HOXA10	121	P31260
PSAPMAGEPVRPSCP	PCDHGC4	791	Q9Y5F7
EMPPRCSSPTVGPPP	PPFIBP2	356	Q8ND30
PSPMLPLPVAEGCPP	INO80B	191	Q9C086
IPPRMTPKPCQDPPA	PROX2	316	Q3B8N5
CVIPQDPMDPPALPP	DOCK3	1961	Q8IZD9
CLPLPPPPPAFKSME	CEBPB	11	P17676
LCCPPPVPSNGPMQP	HUNK	636	P57058
PRMKPSPLTPCPPGV	MAMSTR	141	Q6ZN01
MAPPPACRSPMSPPP	C4orf48	1	Q5BLP8
ACRSPMSPPPPPLLL	C4orf48	6	Q5BLP8
APPPGCATLPRMPPD	PRRT1	96	Q99946
AERPPSPRSPLMPGC	SAC3D1	36	A6NKF1
MARARGSPCPPLPPG	LRRC4B	1	Q9NT99
MQPPPPGPLGDCLRD	TMEM120A	1	Q9BXJ8
GGEMARAPPPPRPCL	PRR14	366	Q9BWN1
PMCPVPPACPEPKYR	SLC25A47	146	Q6Q0C1
PGSPLPMACPGIMRP	SEC31B	911	Q9NQW1
GMSPPPCKLPCLSPP	ESRP2	571	Q9H6T0
CLSAQMLAPPPPGLP	NFIC	436	P08651
PCFSMPRGKPPAPSP	MLXIPL	486	Q9NP71
IPPSPPSCGPGSPLM	TICRR	1506	Q7Z2Z1
CPMSVLHRVCPPPPP	WDR97	506	A6NE52
PPALSCPPPQPAMLE	SPCS1	56	Q9Y6A9
MPSPLGPPCLPVMDP	ZNF446	1	Q9NWS9
MAPPPAPLLAPRPGE	ZNF688	1	P0C7X2
CPPRMPPPPGFSAVV	ZNF598	676	Q86UK7
MLSAAPEPPPRPPPA	TTC9B	11	Q8N6N2
VRKQMPPPPPCPGRE	SHC1	406	P29353
GLCMEPRDAPPPRKP	ZAN	2741	Q9Y493
GGEARCMIPPPPSPL	nan	11	A6NHS1