Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	MLL3/4 complex	PAXIP1 NCOA6	2.45e-04	12	41	2	GO:0044666
Domain	NPIP	NPIPA1 NPIPB3 NPIPA3 NPIPB5 NPIPB13 NPIPA7 NPIPB2 NPIPA5	9.57e-19	14	42	8	IPR009443
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2	4.22e-08	4	42	3	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	4.22e-08	4	42	3	PF14914
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	4.22e-08	4	42	3	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2	4.22e-08	4	42	3	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2	4.22e-08	4	42	3	IPR015753
Domain	LRR_8	LRRC37A LRRC37A3 LRRC37A2	6.66e-03	171	42	3	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A LRRC37A3 LRRC37A2	7.33e-03	177	42	3	IPR003591
Domain	LRR_TYP	LRRC37A LRRC37A3 LRRC37A2	7.33e-03	177	42	3	SM00369
Domain	LRR	LRRC37A LRRC37A3 LRRC37A2	1.04e-02	201	42	3	PS51450
Domain	LRR_1	LRRC37A LRRC37A3 LRRC37A2	1.30e-02	219	42	3	PF00560
Pathway	KEGG_MEDICUS_REFERENCE_DRD1_GNAS_AC_PKA_SIGNALING_PATHWAY	GNAS CREB5	3.01e-04	16	23	2	M47551
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	GNAS CREB5	6.88e-04	24	23	2	M47520
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	GNAS CREB5	8.72e-04	27	23	2	M47518
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	GNAS CREB5	9.38e-04	28	23	2	M47647
Pathway	WP_KLEEFSTRA_SYNDROME	PAXIP1 NCOA6	1.01e-03	29	23	2	M48076
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	GNAS CREB5	1.01e-03	29	23	2	M47515
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	GNAS CREB5	1.01e-03	29	23	2	M47627
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	GNAS CREB5	1.15e-03	31	23	2	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	GNAS CREB5	1.23e-03	32	23	2	M47506
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	8.65e-09	4	46	3	22419166
Pubmed	Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.	NPIPA1 NPIPA3 NPIPA5	8.65e-09	4	46	3	18055785
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2	2.58e-07	10	46	3	23064749
Pubmed	Positive selection of a gene family during the emergence of humans and African apes.	NPIPA1 NPIPA8	1.71e-06	2	46	2	11586358
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	5.13e-06	3	46	2	11948212
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	PAXIP1 SUGP1 NCOA6 MEGF8 RFX1 LRRC37A3 ATXN7	1.95e-05	638	46	7	31182584
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP170 WNK1 BIRC6 PCDH18 SH2B1 UNC80	4.56e-05	493	46	6	15368895
Pubmed	Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.	PAXIP1 NCOA6	4.77e-05	8	46	2	17178841
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	PAXIP1 NCOA6 RFX1	8.93e-05	65	46	3	22496869
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	PAXIP1 NCOA6	1.32e-04	13	46	2	17761849
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	PAXIP1 NCOA6	1.78e-04	15	46	2	17925232
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	PAXIP1 NCOA6	2.03e-04	16	46	2	24368734
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	NCOA6 WNK1 BIRC6 UNC80	2.25e-04	225	46	4	12168954
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	PAXIP1 NCOA6	2.30e-04	17	46	2	26180087
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	NPIPA1 NPIPB4 CLN3	2.50e-04	92	46	3	10493829
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	NCOA6 ZNF469 SIN3A WNK1 SH2B1	2.55e-04	430	46	5	35044719
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	PAXIP1 NCOA6	2.58e-04	18	46	2	17500065
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	PAXIP1 NCOA6	3.20e-04	20	46	2	29785026
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	PAXIP1 NCOA6	3.20e-04	20	46	2	19047629
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	CIZ1 CEP170 BIRC6	3.80e-04	106	46	3	18654987
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	PAXIP1 NCOA6	3.89e-04	22	46	2	26886794
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PAXIP1 SUGP1 NCOA6 SIN3A	4.36e-04	268	46	4	33640491
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PAXIP1 NCOA6 MEGF8 PCNX3 WNK1 BIRC6 CLN3	5.81e-04	1105	46	7	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CIZ1 CEP170 ZSWIM8 ZNF469 SIN3A ATXN7 UNC80	6.16e-04	1116	46	7	31753913
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CIZ1 CEP170 NCOA6 SIN3A RFX1	7.74e-04	549	46	5	38280479
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	CEP170 GNAS BIRC6	8.36e-04	139	46	3	25476789
Pubmed	GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.	CHL1 SIN3A	8.80e-04	33	46	2	21658281
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PAXIP1 NCOA6 SIN3A RFX1	1.07e-03	341	46	4	32971831
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ZSWIM8 DRAP1 MEGF8 WNK1 ATXN7	1.22e-03	608	46	5	16713569
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB3 NPIPB4 NPIPB5 CLN3 NPIPA8	8.43e-07	172	46	5	chr16p12
Cytoband	16p13.11	NPIPA1 NPIPA3 NPIPA5	1.64e-06	23	46	3	16p13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	NPIPA1 NPIPA3 NPIPA7 NPIPB2 UBALD1 NPIPA5	4.22e-06	426	46	6	chr16p13
Cytoband	16p12.2	NPIPB3 NPIPB4 NPIPB5	7.14e-06	37	46	3	16p12.2
Cytoband	16p11.2	NPIPB13 NPIPB12 SH2B1	9.43e-04	191	46	3	16p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p11	NPIPB13 NPIPB12 SH2B1	2.75e-03	278	46	3	chr16p11
Cytoband	17q21.31	LRRC37A LRRC37A2	3.10e-03	82	46	2	17q21.31
GeneFamily	SH2 domain containing	LCP2 SH2B1	4.46e-03	101	18	2	741
Coexpression	LAIHO_COLORECTAL_CANCER_SERRATED_DN	NPIPA1 NPIPB3 GRINA SH2B1	1.39e-05	85	45	4	M17423
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPIPB3 IQCJ-SCHIP1 NPIPB5 FREM3 CREB5	1.10e-06	178	46	5	ad187db4c40b9078d54dd915c143e0172b2f47b8
Computational	Neighborhood of NUMA1	CIZ1 SIN3A SH2B1	1.67e-04	56	21	3	GCM_NUMA1
Computational	Neighborhood of GSPT1	CIZ1 SIN3A WNK1 SH2B1	2.86e-04	169	21	4	GCM_GSPT1
Disease	Hyperpotassemia and Hypertension, Familial	GNAS WNK1	7.22e-05	10	38	2	C2713447
Disease	Pseudohypoaldosteronism, Type I	GNAS WNK1	7.22e-05	10	38	2	C0268436
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	GNAS WNK1	7.22e-05	10	38	2	C1449843
Disease	Pseudohypoaldosteronism, Type II	GNAS WNK1	7.22e-05	10	38	2	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	GNAS WNK1	7.22e-05	10	38	2	C1449842
Disease	Pseudohypoaldosteronism	GNAS WNK1	7.22e-05	10	38	2	C0033805
Disease	uric acid measurement	SUGP1 GNAS DRAP1 CASTOR1 PCNX3 BIRC6	1.20e-04	610	38	6	EFO_0004761
Disease	phosphatidylcholine 40:7 measurement	SUGP1 NPIPA1	1.25e-04	13	38	2	EFO_0021477
Disease	cigarettes per day measurement	CPEB3 WNK1 CLN3 CREB5 SH2B1	2.36e-04	438	38	5	EFO_0006525
Disease	Mental Retardation, Psychosocial	CHL1 SIN3A GNAS	7.65e-04	139	38	3	C0025363
Disease	Profound Mental Retardation	CHL1 SIN3A GNAS	7.65e-04	139	38	3	C0020796
Disease	Mental deficiency	CHL1 SIN3A GNAS	7.65e-04	139	38	3	C0917816
Disease	waist-hip ratio	CPEB3 LCP2 CASTOR1 MEGF8 WNK1 BIRC6 SH2B1	8.56e-04	1226	38	7	EFO_0004343
Disease	urate measurement	NCOA6 SIN3A GNAS DRAP1 PCNX3 BIRC6	9.22e-04	895	38	6	EFO_0004531
Disease	glucose measurement	LRRC37A MEGF8 RFX1 LRRC37A3	1.41e-03	380	38	4	EFO_0004468
Disease	diglyceride measurement	CPEB3 SUGP1	1.98e-03	51	38	2	EFO_0010223
Disease	comparative body size at age 10, self-reported	GNAS WNK1 SH2B1 LRRC37A2	2.04e-03	420	38	4	EFO_0009819

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGQHQPILTPGHSQP	GNAS	351	P84996
NHHSPGQTPTLGQPE	CEP170	1526	Q5SW79
PHGTNQHSPQVGPTA	BIRC6	2771	Q9NR09
TQHGPSPTVHPIQSP	CASTOR1	166	Q8WTX7
GEEETSQPPPQASHP	DRAP1	151	Q14919
NRMGHQPPPPTQQHS	NPIPB3	241	Q92617
NRMGHQPPPPTQQHS	NPIPA1	241	Q9UND3
NRMGHQPPPPTQQHS	NPIPB12	241	F8W0I5
GEEFPTQPQQQHPHQ	PCDH18	951	Q9HCL0
QPPPSPQQHQLFGHD	PAXIP1	581	Q6ZW49
PHPPLHTGNQAQVSP	CREB5	331	Q02930
SPTQQETPGQPPEHH	LRRC37A3	376	O60309
QPQVFPGQDPDSPQH	GRINA	116	Q7Z429
SPTQQETPGQPPEHH	LRRC37A2	376	A6NM11
SPTQQETPGQPPEHH	LRRC37A	376	A6NMS7
QPSQPSDHHETPPAA	CHL1	696	O00533
NNPPVAHPTPENTAG	PCNX3	1851	Q9H6A9
APDTGVHTVHIQPPP	MEGF8	2516	Q7Z7M0
NRMGHQPPPPTQQHS	NPIPB5	241	A8MRT5
NRMGHQPPPPTQQHS	NPIPA3	241	F8WFD2
NRMGHQPPPPTQQHS	NPIPB4	241	C9JG80
TSQEPHQNPHGVIPS	ATXN7	421	O15265
PQHHFEQNSIIPGPP	MFSD14A	416	Q96MC6
PQQPPVNSLPSSHGH	NCOA6	1181	Q14686
GLAQTQHHQQPPPPA	CPEB3	156	Q8NE35
GHHPPPQRPEETSAQ	HSD17B14	91	Q9BPX1
NRMGHQPPPPTQQHS	NPIPB13	241	A6NJU9
NRMGHQPPPPTQQHS	NPIPA7	241	E9PJI5
NRMGHQPPPPTQQHS	NPIPA8	241	P0DM63
ILNAPTHPPGHPGQQ	FREM3	346	P0C091
QQEPTTSHDPPQPPE	SH2B1	631	Q9NRF2
NRMGHQPPPPTQQHS	NPIPA5	241	E9PKD4
VHGTQQVHSPPEQSP	RFX1	196	P22670
SHAHPAPPVAPVQGQ	SIN3A	101	Q96ST3
PPVPNGNLHQHDPQD	IQCJ-SCHIP1	221	B3KU38
NQSHVDPGPTPIPHN	CLN3	71	Q13286
HTQAQPSVQPQEHPP	CIZ1	436	Q9ULV3
QPPEQTHEQPHTQPQ	CIZ1	456	Q9ULV3
SPNNKSPTGPHPLEH	NDUFV1-DT	11	Q8NBR9
SPQPPHPGEITNAHN	SUGP1	61	Q8IWZ8
TTEHTPNHHVPQPPQ	UNC80	1826	Q8N2C7
PGQQGHTPQLHTPSS	SARG	221	Q9BW04
NRMGHQPPPPTQQHS	NPIPB2	256	A6NJ64
PNHSRGDPSHVTQPP	ZNF469	2511	Q96JG9
PPEEETHSQPVNPHS	ZSWIM8	1646	A7E2V4
PGHIPSTVQAQSQPH	WNK1	691	Q9H4A3
TAASPPGGPQHHQPQ	UBALD1	126	Q8TB05
HSPLPPPQTNHEEPS	LCP2	206	Q13094