Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC7A9 MFSD14A SLC7A4 TMC1 CLCN4 SLC12A9 SLC50A1 SLC22A23 SLC22A2 XKR8 SLC34A3 ATP1A3 ATP1A4 TMEM109 SLC7A11 LMBRD1	2.60e-08	1289	48	16	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC7A9 MFSD14A SLC7A4 TMC1 CLCN4 SLC12A9 SLC50A1 SLC22A23 SLC22A2 SLC34A3 ATP1A3 ATP1A4 TMEM109 SLC7A11	4.25e-07	1180	48	14	GO:0022857
GeneOntologyMolecularFunction	basic amino acid transmembrane transporter activity	SLC7A9 SLC7A4 SLC22A2	1.44e-05	20	48	3	GO:0015174
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC7A9 CLCN4 SLC12A9 SLC22A2 SLC34A3 ATP1A3 ATP1A4 SLC7A11	1.63e-05	477	48	8	GO:0022804
GeneOntologyMolecularFunction	macrophage colony-stimulating factor receptor binding	IL34 CSF1	1.69e-05	3	48	2	GO:0005157
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC7A9 SLC7A4 SLC22A2 SLC7A11	1.18e-04	105	48	4	GO:0015171
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A3 ATP1A4	2.52e-04	10	48	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A3 ATP1A4	2.52e-04	10	48	2	GO:0005391
GeneOntologyMolecularFunction	sulfur amino acid transmembrane transporter activity	SLC7A9 SLC7A11	3.07e-04	11	48	2	GO:0000099
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A3 ATP1A4	3.07e-04	11	48	2	GO:0008556
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	SLC7A9 SLC22A2 SLC7A11	4.25e-04	61	48	3	GO:1901682
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	ERBB2 FLT4 CSF1R	5.13e-04	65	48	3	GO:0004714
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC7A9 SLC22A2 SLC7A11	6.64e-04	71	48	3	GO:0015179
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC7A9 CLCN4 SLC12A9 SLC34A3 SLC7A11	7.03e-04	296	48	5	GO:0015291
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	ERBB2 FLT4 CSF1R	1.12e-03	85	48	3	GO:0019199
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	CMKLR2 ERBB2 CYSLTR2 FLT4 CSF1R OR56A3 GPR156 GCGR GPR119 OR9A2	1.21e-03	1353	48	10	GO:0004888
GeneOntologyMolecularFunction	hormone binding	CMKLR2 GCGR ATP1A3	1.95e-03	103	48	3	GO:0042562
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TMC1 CLCN4 SLC12A9 SLC34A3 ATP1A3 ATP1A4 TMEM109	2.70e-03	793	48	7	GO:0015075
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC7A9 SLC7A11	2.85e-03	33	48	2	GO:0072349
GeneOntologyMolecularFunction	phosphatidylcholine binding	ESYT3 GPR119	3.02e-03	34	48	2	GO:0031210
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP1A3 ATP1A4	3.38e-03	36	48	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP1A3 ATP1A4	3.38e-03	36	48	2	GO:0015662
GeneOntologyMolecularFunction	antiporter activity	SLC7A9 CLCN4 SLC7A11	4.45e-03	138	48	3	GO:0015297
GeneOntologyMolecularFunction	G protein-coupled receptor activity	CMKLR2 CYSLTR2 OR56A3 GPR156 GCGR GPR119 OR9A2	4.91e-03	884	48	7	GO:0004930
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TMC1 SLC12A9 SLC34A3 ATP1A3 ATP1A4 TMEM109	4.95e-03	664	48	6	GO:0008324
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TMC1 SLC12A9 SLC34A3 ATP1A3 ATP1A4	5.04e-03	465	48	5	GO:0046873
GeneOntologyMolecularFunction	protein tyrosine kinase activity	ERBB2 FLT4 CSF1R	5.11e-03	145	48	3	GO:0004713
GeneOntologyMolecularFunction	quaternary ammonium group binding	ESYT3 GPR119	5.47e-03	46	48	2	GO:0050997
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC12A9 SLC34A3 ATP1A3 ATP1A4	5.85e-03	301	48	4	GO:0022853
GeneOntologyMolecularFunction	growth factor binding	ERBB2 FLT4 CSF1R	6.25e-03	156	48	3	GO:0019838
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP4F22 LMBRD1 CYP4A22	7.18e-03	164	48	3	GO:0046906
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	SLC12A9 ATP1A3 ATP1A4	7.54e-03	167	48	3	GO:0015079
GeneOntologyMolecularFunction	peptide hormone binding	CMKLR2 GCGR	7.75e-03	55	48	2	GO:0017046
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CLCN4 SLC12A9 SLC34A3	8.05e-03	171	48	3	GO:0015103
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC34A3 ATP1A3 ATP1A4	8.05e-03	171	48	3	GO:0015081
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC50A1 SLC22A2	8.87e-03	59	48	2	GO:1901505
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TMC1 CLCN4 SLC12A9 SLC34A3 ATP1A3 ATP1A4	9.26e-03	758	48	6	GO:0015318
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	TMC1 CLCN4 TMEM109	9.54e-03	182	48	3	GO:0005244
GeneOntologyMolecularFunction	ATPase-coupled monoatomic cation transmembrane transporter activity	ATP1A3 ATP1A4	9.76e-03	62	48	2	GO:0019829
GeneOntologyMolecularFunction	voltage-gated channel activity	TMC1 CLCN4 TMEM109	9.82e-03	184	48	3	GO:0022832
GeneOntologyBiologicalProcess	positive regulation of macrophage proliferation	IL34 CSF1 CSF1R	4.38e-07	7	49	3	GO:0120041
GeneOntologyBiologicalProcess	regulation of macrophage proliferation	IL34 CSF1 CSF1R	7.00e-07	8	49	3	GO:0120040
GeneOntologyBiologicalProcess	microglial cell proliferation	IL34 CSF1 CSF1R	1.05e-06	9	49	3	GO:0061518
GeneOntologyBiologicalProcess	neutrophil homeostasis	CSF1 CSF1R XKR8 SLC7A11	1.39e-06	35	49	4	GO:0001780
GeneOntologyBiologicalProcess	macrophage proliferation	IL34 CSF1 CSF1R	3.54e-06	13	49	3	GO:0061517
GeneOntologyBiologicalProcess	basic amino acid transmembrane transport	SLC7A9 SLC7A4 SLC22A2	1.19e-05	19	49	3	GO:1990822
GeneOntologyBiologicalProcess	basic amino acid transport	SLC7A9 SLC7A4 SLC22A2	1.88e-05	22	49	3	GO:0015802
GeneOntologyBiologicalProcess	positive regulation of macrophage chemotaxis	IL34 CSF1 CSF1R	3.15e-05	26	49	3	GO:0010759
GeneOntologyBiologicalProcess	glial cell proliferation	IL34 CYSLTR2 CSF1 CSF1R	5.41e-05	87	49	4	GO:0014009
GeneOntologyBiologicalProcess	monocyte homeostasis	CSF1 CSF1R	5.50e-05	5	49	2	GO:0035702
GeneOntologyBiologicalProcess	positive regulation of macrophage migration	IL34 CSF1 CSF1R	6.54e-05	33	49	3	GO:1905523
GeneOntologyBiologicalProcess	monocyte differentiation	IL34 CSF1 CSF1R	7.82e-05	35	49	3	GO:0030224
GeneOntologyBiologicalProcess	L-cystine transport	SLC7A9 SLC7A11	8.24e-05	6	49	2	GO:0015811
GeneOntologyBiologicalProcess	regulation of macrophage chemotaxis	IL34 CSF1 CSF1R	9.25e-05	37	49	3	GO:0010758
GeneOntologyBiologicalProcess	potassium ion homeostasis	SLC12A9 ATP1A3 ATP1A4	9.25e-05	37	49	3	GO:0055075
GeneOntologyBiologicalProcess	macrophage colony-stimulating factor signaling pathway	CSF1 CSF1R	1.15e-04	7	49	2	GO:0038145
GeneOntologyBiologicalProcess	amino acid transmembrane transport	SLC7A9 SLC7A4 SLC22A2 SLC7A11	1.89e-04	120	49	4	GO:0003333
GeneOntologyBiologicalProcess	positive regulation of monocyte differentiation	IL34 CSF1	2.46e-04	10	49	2	GO:0045657
GeneOntologyBiologicalProcess	establishment or maintenance of transmembrane electrochemical gradient	ATP1A3 ATP1A4	3.00e-04	11	49	2	GO:0010248
GeneOntologyBiologicalProcess	macrophage chemotaxis	IL34 CSF1 CSF1R	3.20e-04	56	49	3	GO:0048246
GeneOntologyBiologicalProcess	regulation of macrophage migration	IL34 CSF1 CSF1R	3.20e-04	56	49	3	GO:1905521
GeneOntologyBiologicalProcess	cellular response to macrophage colony-stimulating factor stimulus	CSF1 CSF1R	4.24e-04	13	49	2	GO:0036006
GeneOntologyBiologicalProcess	sulfur amino acid transport	SLC7A9 SLC7A11	4.24e-04	13	49	2	GO:0000101
GeneOntologyBiologicalProcess	leukocyte homeostasis	CSF1 CSF1R XKR8 SLC7A11	4.76e-04	153	49	4	GO:0001776
GeneOntologyBiologicalProcess	sulfur compound transport	SLC7A9 SLC22A2 SLC7A11	4.96e-04	65	49	3	GO:0072348
GeneOntologyBiologicalProcess	regulation of granulocyte chemotaxis	IL34 CSF1 CSF1R	4.96e-04	65	49	3	GO:0071622
GeneOntologyBiologicalProcess	response to macrophage colony-stimulating factor	CSF1 CSF1R	7.35e-04	17	49	2	GO:0036005
GeneOntologyBiologicalProcess	intracellular potassium ion homeostasis	ATP1A3 ATP1A4	7.35e-04	17	49	2	GO:0030007
GeneOntologyBiologicalProcess	sodium ion export across plasma membrane	ATP1A3 ATP1A4	7.35e-04	17	49	2	GO:0036376
GeneOntologyBiologicalProcess	macrophage differentiation	IL34 CSF1 CSF1R	8.15e-04	77	49	3	GO:0030225
GeneOntologyBiologicalProcess	positive regulation of macrophage differentiation	IL34 CSF1	8.26e-04	18	49	2	GO:0045651
GeneOntologyBiologicalProcess	macrophage migration	IL34 CSF1 CSF1R	8.78e-04	79	49	3	GO:1905517
GeneOntologyBiologicalProcess	regulation of myeloid leukocyte differentiation	IL34 CSF1 CSF1R TCTA	9.12e-04	182	49	4	GO:0002761
GeneOntologyBiologicalProcess	regulation of monocyte differentiation	IL34 CSF1	1.02e-03	20	49	2	GO:0045655
GeneOntologyBiologicalProcess	positive regulation of myeloid leukocyte differentiation	IL34 CSF1 CSF1R	1.05e-03	84	49	3	GO:0002763
GeneOntologyBiologicalProcess	L-alpha-amino acid transmembrane transport	SLC7A9 SLC22A2 SLC7A11	1.16e-03	87	49	3	GO:1902475
GeneOntologyBiologicalProcess	amino acid transport	SLC7A9 SLC7A4 SLC22A2 SLC7A11	1.18e-03	195	49	4	GO:0006865
GeneOntologyBiologicalProcess	export across plasma membrane	SLC22A2 ATP1A3 ATP1A4	1.32e-03	91	49	3	GO:0140115
GeneOntologyCellularComponent	CSF1-CSF1R complex	CSF1 CSF1R	5.16e-06	2	48	2	GO:1990682
GeneOntologyCellularComponent	sodium:potassium-exchanging ATPase complex	ATP1A3 ATP1A4	3.36e-04	12	48	2	GO:0005890
GeneOntologyCellularComponent	apical part of cell	SLC7A9 ERBB2 SLC22A2 SLC34A3 SLC7A11 MTDH CYP4A22	3.79e-04	592	48	7	GO:0045177
GeneOntologyCellularComponent	apical plasma membrane	SLC7A9 ERBB2 SLC22A2 SLC34A3 MTDH CYP4A22	8.30e-04	487	48	6	GO:0016324
GeneOntologyCellularComponent	brush border membrane	SLC7A9 SLC34A3 SLC7A11	9.18e-04	83	48	3	GO:0031526
GeneOntologyCellularComponent	cluster of actin-based cell projections	SLC7A9 TMC1 SLC34A3 SLC7A11	1.70e-03	223	48	4	GO:0098862
MousePheno	absent Langerhans cell	IL34 CSF1 CSF1R	5.00e-07	7	35	3	MP:0008118
MousePheno	decreased Langerhans cell number	IL34 CSF1 CSF1R	1.70e-06	10	35	3	MP:0008119
MousePheno	abnormal Langerhans cell number	IL34 CSF1 CSF1R	3.11e-06	12	35	3	MP:0013411
MousePheno	abnormal Langerhans cell morphology	IL34 CSF1 CSF1R	5.14e-06	14	35	3	MP:0008117
MousePheno	decreased myeloid dendritic cell number	IL34 CSF1 CSF1R	1.36e-05	19	35	3	MP:0008122
MousePheno	abnormal osteocyte dendritic process morphology	CSF1 CSF1R	1.82e-05	3	35	2	MP:0030487
MousePheno	abnormal myeloid dendritic cell number	IL34 CSF1 CSF1R	1.85e-05	21	35	3	MP:0008120
MousePheno	abnormal myeloid dendritic cell morphology	IL34 CSF1 CSF1R	5.02e-05	29	35	3	MP:0006173
MousePheno	abnormal microglial cell morphology	IL34 CSF1 CSF1R ATP1A3	6.32e-05	87	35	4	MP:0000136
MousePheno	round snout	CSF1 CSF1R	9.08e-05	6	35	2	MP:0030188
MousePheno	abnormal glial cell morphology	IL34 ERBB2 CSF1 CSF1R CLDN19 ATP1A3	1.92e-04	345	35	6	MP:0003634
Domain	AA-permease/SLC12A_dom	SLC7A9 SLC7A4 SLC12A9 SLC7A11	2.71e-07	22	48	4	IPR004841
Domain	AA_permease	SLC7A9 SLC7A4 SLC12A9 SLC7A11	2.71e-07	22	48	4	PF00324
Domain	AA/rel_permease1	SLC7A9 SLC7A4 SLC7A11	4.47e-06	13	48	3	IPR002293
Domain	AA_permease_2	SLC7A9 SLC7A4 SLC7A11	4.47e-06	13	48	3	PF13520
Domain	SUGAR_TRANSPORT_1	MFSD14A SLC22A23 SLC22A2	3.10e-05	24	48	3	PS00216
Domain	LMBR1	LMBRD2 LMBRD1	3.87e-05	4	48	2	PF04791
Domain	LMBR1-like_membr_prot	LMBRD2 LMBRD1	3.87e-05	4	48	2	IPR006876
Domain	Sugar_transporter_CS	MFSD14A SLC22A23 SLC22A2	7.50e-05	32	48	3	IPR005829
Domain	P-type_ATPase_IIC	ATP1A3 ATP1A4	9.64e-05	6	48	2	IPR005775
Domain	RECEPTOR_TYR_KIN_III	FLT4 CSF1R	1.79e-04	8	48	2	PS00240
Domain	Tyr_kinase_rcpt_3_CS	FLT4 CSF1R	1.79e-04	8	48	2	IPR001824
Domain	-	ATP1A3 ATP1A4	7.58e-04	16	48	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A3 ATP1A4	7.58e-04	16	48	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP1A3 ATP1A4	8.58e-04	17	48	2	IPR006068
Domain	Cation_ATPase_C	ATP1A3 ATP1A4	8.58e-04	17	48	2	PF00689
Domain	Cation_ATPase_N	ATP1A3 ATP1A4	9.64e-04	18	48	2	PF00690
Domain	Cation_ATPase_N	ATP1A3 ATP1A4	9.64e-04	18	48	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP1A3 ATP1A4	1.08e-03	19	48	2	IPR004014
Domain	Claudin_CS	CLDN19 CLDN23	1.45e-03	22	48	2	IPR017974
Domain	CLAUDIN	CLDN19 CLDN23	1.45e-03	22	48	2	PS01346
Domain	TyrKc	ERBB2 FLT4 CSF1R	1.50e-03	88	48	3	SM00219
Domain	Tyr_kinase_cat_dom	ERBB2 FLT4 CSF1R	1.50e-03	88	48	3	IPR020635
Domain	PROTEIN_KINASE_TYR	ERBB2 FLT4 CSF1R	1.98e-03	97	48	3	PS00109
Domain	Tyr_kinase_AS	ERBB2 FLT4 CSF1R	1.98e-03	97	48	3	IPR008266
Domain	Claudin	CLDN19 CLDN23	2.34e-03	28	48	2	IPR006187
Domain	MFS	MFSD14A SLC22A23 SLC22A2	2.69e-03	108	48	3	PS50850
Domain	-	ATP1A3 ATP1A4	3.05e-03	32	48	2	2.70.150.10
Domain	-	ATP1A3 ATP1A4	3.05e-03	32	48	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP1A3 ATP1A4	3.65e-03	35	48	2	IPR023299
Domain	Sugar_tr	SLC22A23 SLC22A2	3.85e-03	36	48	2	PF00083
Domain	MFS_sugar_transport-like	SLC22A23 SLC22A2	3.85e-03	36	48	2	IPR005828
Domain	ATPase_P-typ_P_site	ATP1A3 ATP1A4	3.85e-03	36	48	2	IPR018303
Domain	P_typ_ATPase	ATP1A3 ATP1A4	3.85e-03	36	48	2	IPR001757
Domain	ATPASE_E1_E2	ATP1A3 ATP1A4	3.85e-03	36	48	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP1A3 ATP1A4	4.07e-03	37	48	2	IPR008250
Domain	E1-E2_ATPase	ATP1A3 ATP1A4	4.07e-03	37	48	2	PF00122
Domain	Pkinase_Tyr	ERBB2 FLT4 CSF1R	4.44e-03	129	48	3	PF07714
Domain	PMP22_Claudin	CLDN19 CLDN23	4.74e-03	40	48	2	PF00822
Domain	MFS_dom	MFSD14A SLC22A23 SLC22A2	4.93e-03	134	48	3	IPR020846
Domain	C2-set_2	SIGLEC1 BTN3A1	4.98e-03	41	48	2	PF08205
Domain	CD80_C2-set	SIGLEC1 BTN3A1	4.98e-03	41	48	2	IPR013162
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB2 FLT4 CSF1R	5.35e-03	138	48	3	IPR001245
Domain	Cyt_P450_E_grp-I	CYP4F22 CYP4A22	5.97e-03	45	48	2	IPR002401
Domain	PMP22/EMP/MP20/Claudin	CLDN19 CLDN23	5.97e-03	45	48	2	IPR004031
Domain	Cyt_P450_CS	CYP4F22 CYP4A22	8.20e-03	53	48	2	IPR017972
Domain	CYTOCHROME_P450	CYP4F22 CYP4A22	9.43e-03	57	48	2	PS00086
Domain	-	CYP4F22 CYP4A22	9.76e-03	58	48	2	1.10.630.10
Domain	p450	CYP4F22 CYP4A22	9.76e-03	58	48	2	PF00067
Domain	Cyt_P450	CYP4F22 CYP4A22	1.04e-02	60	48	2	IPR001128
Domain	V-set	CSF1R SIGLEC1 BTN3A1	1.18e-02	184	48	3	PF07686
Domain	ig	FLT4 CSF1R SIGLEC1	1.28e-02	190	48	3	PF00047
Domain	Immunoglobulin	FLT4 CSF1R SIGLEC1	1.28e-02	190	48	3	IPR013151
Domain	Ig_V-set	CSF1R SIGLEC1 BTN3A1	1.45e-02	199	48	3	IPR013106
Pathway	REACTOME_OTHER_INTERLEUKIN_SIGNALING	IL34 CSF1 CSF1R	7.41e-06	15	37	3	MM15131
Pathway	REACTOME_OTHER_INTERLEUKIN_SIGNALING	IL34 CSF1 CSF1R	3.24e-05	24	37	3	M27385
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	ERBB2 FLT4 CSF1R	3.68e-05	25	37	3	M47934
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC7A9 ESYT3 CLCN4 SLC50A1 SLC22A2 SLC34A3 ATP1A3 ATP1A4 SLC7A11	5.00e-05	681	37	9	MM14985
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY	ERBB2 FLT4 CSF1 CSF1R	6.36e-05	83	37	4	M47961
Pathway	REACTOME_SIGNALING_BY_CSF1_M_CSF_IN_MYELOID_CELLS	IL34 CSF1 CSF1R	7.11e-05	31	37	3	M46423
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY	ERBB2 FLT4 CSF1 CSF1R	8.36e-05	89	37	4	M47963
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC7A9 ESYT3 CLCN4 SLC50A1 SLC22A2 SLC34A3 ATP1A3 ATP1A4 SLC7A11	9.12e-05	736	37	9	M27287
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY	ERBB2 FLT4 CSF1 CSF1R	9.51e-05	92	37	4	M47927
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC7A9 SLC50A1 SLC22A2 SLC34A3 SLC7A11	3.69e-04	238	37	5	MM15076
Pathway	REACTOME_EICOSANOIDS	CYP4F22 CYP4A22	4.35e-04	12	37	2	M27129
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F22 CYP4A22	4.35e-04	12	37	2	M27128
Pathway	REACTOME_EICOSANOIDS	CYP4F22 CYP4A22	4.35e-04	12	37	2	MM14845
Pathway	WP_PROXIMAL_TUBULE_TRANSPORT	SLC7A9 SLC22A2 SLC34A3	4.42e-04	57	37	3	M39812
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC7A9 SLC50A1 SLC22A2 SLC34A3 SLC7A11	4.54e-04	249	37	5	M5988
Pathway	REACTOME_FATTY_ACIDS	CYP4F22 CYP4A22	6.89e-04	15	37	2	M27126
Pathway	KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY	ERBB2 FLT4	7.86e-04	16	37	2	M47424
Pathway	BIOCARTA_ETS_PATHWAY	CSF1 CSF1R	8.89e-04	17	37	2	M14449
Pathway	BIOCARTA_ETS_PATHWAY	CSF1 CSF1R	8.89e-04	17	37	2	MM1435
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F22 CYP4A22	9.99e-04	18	37	2	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F22 CYP4A22	9.99e-04	18	37	2	MM14841
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F22 CYP4A22	1.36e-03	21	37	2	M27137
Pathway	KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION	ATP1A3 ATP1A4	1.64e-03	23	37	2	M4361
Pathway	REACTOME_BASIGIN_INTERACTIONS	SLC7A9 SLC7A11	1.78e-03	24	37	2	MM17215
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F22 CYP4A22	1.94e-03	25	37	2	MM14858
Pathway	REACTOME_BASIGIN_INTERACTIONS	SLC7A9 SLC7A11	1.94e-03	25	37	2	M4974
Pathway	WP_CELL_INTERACTIONS_OF_THE_PANCREATIC_CANCER_MICROENVIRONMENT	CSF1 CSF1R	2.09e-03	26	37	2	M46461
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX	CYSLTR2 CYP4A22	2.60e-03	29	37	2	M39858
Pathway	REACTOME_TIGHT_JUNCTION_INTERACTIONS	CLDN19 CLDN23	2.78e-03	30	37	2	M17967
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC7A9 SLC34A3 SLC7A11	2.81e-03	108	37	3	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC7A9 SLC34A3 SLC7A11	2.89e-03	109	37	3	MM15074
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC7A9 SLC7A11	3.16e-03	32	37	2	MM14957
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC7A9 SLC7A11	3.36e-03	33	37	2	M188
Pubmed	Regulation of microglial proliferation during chronic neurodegeneration.	IL34 CSF1 CSF1R	2.63e-09	3	49	3	23392676
Pubmed	CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions.	IL34 CSF1 CSF1R	2.63e-09	3	49	3	31616414
Pubmed	Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.	IL34 CSF1 CSF1R	2.63e-09	3	49	3	20504948
Pubmed	The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.	IL34 CSF1 CSF1R	2.63e-09	3	49	3	22579672
Pubmed	Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.	IL34 CSF1 CSF1R	2.63e-09	3	49	3	22483114
Pubmed	IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.	IL34 CSF1 CSF1R	2.63e-09	3	49	3	20489731
Pubmed	Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.	IL34 CSF1 CSF1R	1.45e-06	16	49	3	32895539
Pubmed	The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis.	CSF1 CSF1R	1.94e-06	2	49	2	19109221
Pubmed	CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor.	CSF1 CSF1R	1.94e-06	2	49	2	17967422
Pubmed	Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling.	CSF1 CSF1R	1.94e-06	2	49	2	22186992
Pubmed	Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.	CSF1 CSF1R	1.94e-06	2	49	2	17438263
Pubmed	Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression.	ERBB2 MTDH	1.94e-06	2	49	2	22340175
Pubmed	c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages.	CSF1 CSF1R	1.94e-06	2	49	2	17420255
Pubmed	Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.	CSF1 CSF1R	1.94e-06	2	49	2	32756440
Pubmed	Autocrine CSF-1 and CSF-1 receptor coexpression promotes renal cell carcinoma growth.	CSF1 CSF1R	1.94e-06	2	49	2	22052465
Pubmed	Role of colony-stimulating factor-1 in bone metabolism.	CSF1 CSF1R	1.94e-06	2	49	2	7962166
Pubmed	IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells.	IL34 CSF1	1.94e-06	2	49	2	25066464
Pubmed	Transcriptional profiling and pathway analysis of CSF-1 and IL-34 effects on human monocyte differentiation.	IL34 CSF1	1.94e-06	2	49	2	23684409
Pubmed	Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor.	IL34 CSF1R	1.94e-06	2	49	2	23478061
Pubmed	A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations.	CSF1 CSF1R	1.94e-06	2	49	2	16877523
Pubmed	The CSF1-CSF1R pathway in the trigeminal ganglion mediates trigeminal neuralgia via inflammatory responses in mice.	CSF1 CSF1R	1.94e-06	2	49	2	38281257
Pubmed	Increased expression of macrophage colony-stimulating factor and its receptor in patients with endometriosis.	CSF1 CSF1R	1.94e-06	2	49	2	22365076
Pubmed	CSF-1R Inhibitor Development: Current Clinical Status.	CSF1 CSF1R	1.94e-06	2	49	2	28875266
Pubmed	CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization.	CSF1 CSF1R	1.94e-06	2	49	2	33764399
Pubmed	Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.	CSF1 CSF1R	1.94e-06	2	49	2	22902366
Pubmed	Immunotargeting of the xCT Cystine/Glutamate Antiporter Potentiates the Efficacy of HER2-Targeted Immunotherapies in Breast Cancer.	ERBB2 SLC7A11	1.94e-06	2	49	2	32532810
Pubmed	The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1.	CSF1 CSF1R	1.94e-06	2	49	2	2408759
Pubmed	Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice.	CSF1 CSF1R	1.94e-06	2	49	2	16823860
Pubmed	Precision glycocalyx editing as a strategy for cancer immunotherapy.	ERBB2 SIGLEC1	1.94e-06	2	49	2	27551071
Pubmed	Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells.	CSF1 CSF1R	1.94e-06	2	49	2	12372416
Pubmed	Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.	CSF1 CSF1R	1.94e-06	2	49	2	28655719
Pubmed	IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization.	IL34 CSF1	1.94e-06	2	49	2	26095744
Pubmed	Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis.	IL34 CSF1	1.94e-06	2	49	2	31859421
Pubmed	High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers.	IL34 CSF1	1.94e-06	2	49	2	29323162
Pubmed	Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).	IL34 CSF1	1.94e-06	2	49	2	23260168
Pubmed	Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis.	CSF1 CSF1R	1.94e-06	2	49	2	25854167
Pubmed	Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity.	CSF1 CSF1R	1.94e-06	2	49	2	23648053
Pubmed	Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain.	CSF1 CSF1R	1.94e-06	2	49	2	8355686
Pubmed	Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion.	CSF1 CSF1R	1.94e-06	2	49	2	8922060
Pubmed	Interleukin-34-CSF1R Signaling Axis Promotes Epithelial Cell Transformation and Breast Tumorigenesis.	IL34 CSF1R	1.94e-06	2	49	2	33800170
Pubmed	Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathway.	CSF1 CSF1R	1.94e-06	2	49	2	12223521
Pubmed	Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.	CSF1 CSF1R	1.94e-06	2	49	2	19017797
Pubmed	Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer.	CSF1 CSF1R	1.94e-06	2	49	2	29767252
Pubmed	Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.	CSF1 CSF1R	1.94e-06	2	49	2	24652541
Pubmed	Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects.	CSF1 CSF1R	1.94e-06	2	49	2	11756160
Pubmed	Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.	IL34 CSF1	1.94e-06	2	49	2	18467591
Pubmed	Temporal expression and location of colony-stimulating factor 1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1-regulated placental development.	CSF1 CSF1R	1.94e-06	2	49	2	2554332
Pubmed	The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion.	CSF1 CSF1R	1.94e-06	2	49	2	16034075
Pubmed	Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.	CSF1 CSF1R	1.94e-06	2	49	2	22826234
Pubmed	Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator.	CSF1 CSF1R	1.94e-06	2	49	2	34298983
Pubmed	CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.	CSF1 CSF1R	1.94e-06	2	49	2	23451116
Pubmed	M-CSF and IL-34 expression as indicators for growth in sporadic vestibular schwannoma.	IL34 CSF1	1.94e-06	2	49	2	30580386
Pubmed	Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.	CSF1 CSF1R	1.94e-06	2	49	2	26235028
Pubmed	Expression of macrophage colony-stimulating factor and its receptor in hepatic granulomas of Kupffer-cell-depleted mice.	CSF1 CSF1R	1.94e-06	2	49	2	9176397
Pubmed	Blockade of macrophage colony-stimulating factor reduces macrophage proliferation and accumulation in renal allograft rejection.	CSF1 CSF1R	1.94e-06	2	49	2	12614284
Pubmed	Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op mice.	CSF1 CSF1R	1.94e-06	2	49	2	1840281
Pubmed	Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.	CSF1 CSF1R	1.94e-06	2	49	2	22153499
Pubmed	The role of CSF-1 in normal and neoplastic breast physiology.	CSF1 CSF1R	1.94e-06	2	49	2	9893162
Pubmed	Biology and action of colony--stimulating factor-1.	CSF1 CSF1R	1.94e-06	2	49	2	8981357
Pubmed	The prognostic impact of M-CSF, CSF-1 receptor, CD68 and CD3 in prostatic carcinoma.	CSF1 CSF1R	1.94e-06	2	49	2	18510570
Pubmed	The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation.	IL34 CSF1 CSF1R	2.95e-06	20	49	3	22542597
Pubmed	Impacts of macrophage colony-stimulating factor (M-CSF) on the expression of natriuretic peptide precursor type C (NPPC) and regulation of meiotic resumption.	CSF1 CSF1R	5.83e-06	3	49	2	30767584
Pubmed	Enhanced M-CSF/CSF1R Signaling Closely Associates with PrPSc Accumulation in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.	CSF1 CSF1R	5.83e-06	3	49	2	35970974
Pubmed	Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.	ATP1A3 ATP1A4	5.83e-06	3	49	2	26373354
Pubmed	CSF-1-induced Src signaling can instruct monocytic lineage choice.	CSF1 CSF1R	5.83e-06	3	49	2	28159742
Pubmed	VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice.	CSF1 CSF1R	5.83e-06	3	49	2	16172397
Pubmed	Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.	IL34 CSF1R	5.83e-06	3	49	2	23177320
Pubmed	A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy.	CSF1 CSF1R	5.83e-06	3	49	2	30142160
Pubmed	[Expression of cytokines Il-6, IL-34 and M-CSFR in chronic periodontitis and its clinical significance].	IL34 CSF1R	5.83e-06	3	49	2	30899951
Pubmed	CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.	CSF1 CSF1R	5.83e-06	3	49	2	35353625
Pubmed	CSF1/CSF1R signaling mediates malignant pleural effusion formation.	CSF1 CSF1R	5.83e-06	3	49	2	35315360
Pubmed	Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.	CSF1 CSF1R	5.83e-06	3	49	2	23296467
Pubmed	Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.	CSF1 CSF1R	5.83e-06	3	49	2	14749363
Pubmed	Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal.	CSF1 CSF1R	5.83e-06	3	49	2	11297560
Pubmed	Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.	CSF1 CSF1R	5.83e-06	3	49	2	18328744
Pubmed	Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages.	CSF1 CSF1R	5.83e-06	3	49	2	31028249
Pubmed	Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation.	ERBB2 CSF1	1.16e-05	4	49	2	19109434
Pubmed	Langerhans cells arise from monocytes in vivo.	CSF1 CSF1R	1.16e-05	4	49	2	16444257
Pubmed	Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy.	CSF1 CSF1R	1.16e-05	4	49	2	38897209
Pubmed	Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.	CSF1 CSF1R	1.16e-05	4	49	2	26642091
Pubmed	CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE.	IL34 CSF1	1.16e-05	4	49	2	30687013
Pubmed	Heterogeneity among cells that express osteoclast-associated genes in developing bone.	CSF1 CSF1R	1.16e-05	4	49	2	9421432
Pubmed	Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.	ATP1A3 ATP1A4	1.16e-05	4	49	2	21849490
Pubmed	Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.	IL34 CSF1R	1.16e-05	4	49	2	23744080
Pubmed	Nonredundant roles of keratinocyte-derived IL-34 and neutrophil-derived CSF1 in Langerhans cell renewal in the steady state and during inflammation.	IL34 CSF1	1.16e-05	4	49	2	26634935
Pubmed	Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.	CSF1 CSF1R	1.16e-05	4	49	2	22294205
Pubmed	Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development.	CSF1 CSF1R	1.16e-05	4	49	2	1374350
Pubmed	Lack of KIT or FMS internal tandem duplications but co-expression with ligands in AML.	CSF1 CSF1R	1.16e-05	4	49	2	14654075
Pubmed	Tumor-Associated Macrophage Promotes the Survival of Cancer Cells upon Docetaxel Chemotherapy via the CSF1/CSF1R-CXCL12/CXCR4 Axis in Castration-Resistant Prostate Cancer.	CSF1 CSF1R	1.16e-05	4	49	2	34069563
Pubmed	Human microglia maturation is underpinned by specific gene regulatory networks.	CSF1 CSF1R	1.16e-05	4	49	2	37582369
Pubmed	Induction of STAP-1 promotes neurotoxic activation of microglia.	CSF1 CSF1R	1.16e-05	4	49	2	19100238
Pubmed	Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.	CSF1 CSF1R	1.16e-05	4	49	2	9372970
Pubmed	Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer.	IL34 CSF1	1.16e-05	4	49	2	31552020
Pubmed	Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.	ATP1A3 ATP1A4	1.16e-05	4	49	2	2887455
Pubmed	Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.	ERBB2 CSF1R	1.94e-05	5	49	2	1334406
Pubmed	Engineering an inhibitor-resistant human CSF1R variant for microglia replacement.	CSF1 CSF1R	1.94e-05	5	49	2	36584406
Pubmed	Multiple genes encode the human Na+,K+-ATPase catalytic subunit.	ATP1A3 ATP1A4	1.94e-05	5	49	2	3035563
Pubmed	CSF-1 controls cerebellar microglia and is required for motor function and social interaction.	IL34 CSF1	1.94e-05	5	49	2	31350310
Pubmed	Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection.	CSF1 CSF1R	1.94e-05	5	49	2	12517946
Pubmed	Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice.	CSF1 CSF1R	1.94e-05	5	49	2	15178709
Interaction	CLRN1 interactions	CLDN19 SLC34A3 TMEM140 UNC50	6.44e-07	29	48	4	int:CLRN1
Interaction	SLC7A4 interactions	ERBB2 SLC7A4	5.55e-06	2	48	2	int:SLC7A4
Interaction	ERGIC3 interactions	CLDN19 ATP1A3 LMBRD2 TMEM109 TMEM140 YIPF3 UNC50	1.49e-05	340	48	7	int:ERGIC3
Interaction	CX3CL1 interactions	ERBB2 FLT4 SLC12A9 ATP1A3	2.45e-05	71	48	4	int:CX3CL1
Interaction	PDZK1IP1 interactions	SLC22A2 CLDN19 TMEM109 TMEM140	3.92e-05	80	48	4	int:PDZK1IP1
Interaction	CHRM3 interactions	FLT4 ATP1A3 ATP1A4 YIPF3	4.12e-05	81	48	4	int:CHRM3
Interaction	CLEC2D interactions	SLC22A23 CLDN19 ATP1A3 LMBRD2 SLC7A11	1.03e-04	197	48	5	int:CLEC2D
Interaction	SAR1A interactions	FLT4 SEC24C CLDN19 TMEM109 MTDH UNC50	1.17e-04	325	48	6	int:SAR1A
GeneFamily	Solute carriers	SLC7A9 SLC7A4 SLC12A9 SLC50A1 SLC22A23 SLC22A2 SLC25A34 SLC34A3 SLC7A11	9.64e-08	395	38	9	752
GeneFamily	ATPase Na+/K+ transporting subunits	ATP1A3 ATP1A4	8.97e-05	7	38	2	1208
GeneFamily	Claudins	CLDN19 CLDN23	1.06e-03	23	38	2	488
GeneFamily	Cytochrome P450 family 4	CYP4F22 CYP4A22	2.59e-03	36	38	2	1003
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SIGLEC1 BTN3A1	3.19e-03	40	38	2	592
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT4 CSF1R	3.19e-03	40	38	2	321
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ERBB2 CSF1R SIGLEC1 BTN3A1	9.14e-03	394	38	4	471
GeneFamily	G protein-coupled receptors, Class A orphans	CMKLR2 GPR119	1.17e-02	78	38	2	262
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	IL34 MFSD14A ERBB2 CSF1 SLC50A1 SLC22A23 TMEM109 YIPF3 UNC50	3.47e-06	681	48	9	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	IL34 MFSD14A ERBB2 CSF1 SLC50A1 SLC22A23 TMEM109 YIPF3 UNC50	4.49e-06	703	48	9	MM1055
ToppCell	facs-Lung-EPCAM-18m-Hematologic-Proliferating_Immune\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R SLC22A2 SIGLEC1 ATP1A3	2.88e-05	160	49	4	7217730ae14840b935b3bf9aa49becbcbcd8a682
ToppCell	facs-Lung-EPCAM-18m-Hematologic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R SLC22A2 SIGLEC1 ATP1A3	2.88e-05	160	49	4	317ef81460c1a31b51119a6309b11be6a8d4ea3e
ToppCell	facs-Lung-EPCAM-18m-Hematologic-leukocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSF1R SLC22A2 SIGLEC1 ATP1A3	2.88e-05	160	49	4	e6191240c93da34fc4431a35ef496edf323cb41e
ToppCell	facs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 SLC22A23 GCGR ATP1A4	3.02e-05	162	49	4	14e9f8aaba308619eb9da90796c336e76cedac1f
ToppCell	facs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 SLC22A23 GCGR ATP1A4	3.02e-05	162	49	4	860ebf2390b4ad86475ad54717cbefcf61cd3b2a
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSF1R SLC12A9 SIGLEC1 ATP1A3	3.25e-05	165	49	4	354978d4f35154d7b2e36e94de669e045adef512
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MFSD14A CMKLR2 XKR8 CLDN23	3.73e-05	171	49	4	f047a0cc2ce0a062ec502aa9cb91b1202f437f29
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMKLR2 FLT4 SLC22A23 TMEM140	4.09e-05	175	49	4	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CSF1R SLC25A34 SIGLEC1 CLDN23	4.56e-05	180	49	4	ba4c1fb55e8f1095bea6968417fefcf5f700926b
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 FLT4 CSF1 TMEM140	4.66e-05	181	49	4	4df7972f88117108698efd06b124b232f8588981
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 FLT4 CSF1 TMEM140	4.66e-05	181	49	4	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMKLR2 FLT4 SLC22A23 TMEM140	4.86e-05	183	49	4	a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMKLR2 FLT4 SLC22A23 TMEM140	4.86e-05	183	49	4	13ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMKLR2 FLT4 SLC22A23 TMEM140	5.86e-05	192	49	4	4e63d95f75fe6eb3f817e84528883e95093c5bbd
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMKLR2 FLT4 SLC22A23 TMEM140	5.86e-05	192	49	4	fa0ef05a32c661bdd59b5a9b6f75fd647ee937f3
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Activated_DCs\|normal_Pleural_Fluid / Location, Cell class and cell subclass	SLC22A23 GCGR ATP1A4 SLC7A11	6.10e-05	194	49	4	219056d4ad256cda73208b8c570bbf689219df83
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC7A4 CSF1 CYP4F22 ATP1A4	6.47e-05	197	49	4	7619924615a43011b4a86efbe6e7e5445f96722b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	ESYT3 SLC50A1 TMEM109 UNC50	6.86e-05	200	49	4	be83f442179ba4217d12f0458059586ff3130991
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC25A34 CLDN19 SBK2	9.76e-05	81	49	3	a0b45dc22077805eba94689568b874415f515d61
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC25A34 CLDN19 SBK2	9.76e-05	81	49	3	2c58dbad21e0fbe46b005bcaf45139d098a2057a
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC25A34 CLDN19 SBK2	9.76e-05	81	49	3	571884bcf4282053c6170609ae0c794a6df05cd9
Drug	Imipenem [74431-23-5]; Up 200; 13.4uM; HL60; HG-U133A	SLC7A9 CSF1 CSF1R SIGLEC1 PIGV TMEM140	4.35e-06	200	49	6	1724_UP
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A3 ATP1A4	4.54e-05	7	44	2	DOID:0060178 (implicated_via_orthology)
Disease	osteopetrosis (implicated_via_orthology)	CSF1 CLCN4	4.54e-05	7	44	2	DOID:13533 (implicated_via_orthology)
Disease	carcinoma (implicated_via_orthology)	ERBB2 FLT4 CSF1R	1.21e-04	64	44	3	DOID:305 (implicated_via_orthology)
Disease	nervous system disease (implicated_via_orthology)	ATP1A3 ATP1A4	1.42e-04	12	44	2	DOID:863 (implicated_via_orthology)
Disease	anti-basement membrane glomerulonephritis (implicated_via_orthology)	CSF1 CSF1R	1.96e-04	14	44	2	DOID:4780 (implicated_via_orthology)
Disease	Neoplasm Metastasis	ERBB2 CSF1R SLC7A11 MTDH	3.07e-04	217	44	4	C0027627
Disease	Mammary Neoplasms, Human	ERBB2 CSF1 CSF1R MTDH RNF182	1.07e-03	525	44	5	C1257931
Disease	Mammary Carcinoma, Human	ERBB2 CSF1 CSF1R MTDH RNF182	1.07e-03	525	44	5	C4704874
Disease	Mammary Neoplasms	ERBB2 CSF1 CSF1R MTDH RNF182	1.09e-03	527	44	5	C1458155
Disease	Breast Carcinoma	ERBB2 CSF1 CSF1R MTDH RNF182	1.19e-03	538	44	5	C0678222
Disease	creatinine measurement, chronic kidney disease	SLC7A9 SLC22A2	1.25e-03	35	44	2	EFO_0003884, EFO_0004518
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ERBB2 FLT4 YIPF3	1.41e-03	148	44	3	C0279702
Disease	cups of coffee per day measurement	ATP1A3 ATP1A4	1.64e-03	40	44	2	EFO_0006782
Disease	abdominal adipose tissue measurement	ATP1A3 ATP1A4	2.85e-03	53	44	2	EFO_0803316

Protein segments in the cluster

Peptide	Gene	Start	Entry
YSLTLQGLGISWLGL	ERBB2	441	P04626
LAGYLGLSITWLLLG	ESYT3	51	A0FGR9
LLLGGAGYFLWQQQE	BTN3A1	261	O00481
LQLLGYFLALGGWVG	CLDN19	6	Q8N6F1
LGIGFTLCGRYWLDL	ACSM4	246	P0C7M7
SGFIIRGYLGKWTLL	CLCN4	191	P51793
FLIGWNVLLEYIIGG	SLC7A4	116	O43246
WVAGVYLLLGFLLLP	SLC34A3	486	Q8N130
FGNWAFLGVFLIGLI	LMBRD1	496	Q9NUN5
WLLVEGLYLHNLLGL	GCGR	241	P47871
IAGLWLVSYLIGFLP	GPR119	126	Q8TDV5
LGLGFQILQLAWYGF	MFSD14A	316	Q96MC6
YGILLWEIFSLGLNP	CSF1R	841	P07333
TWLRYLGIFLGVALG	IL34	6	Q6ZMJ4
ILVLLAVGGLLFYRW	CSF1	506	P09603
AAWLFYGLTILGLIV	SLC7A9	381	P82251
RIGYGLLLLNGQTWF	CYP4A22	126	Q5TCH4
LLLLFLLGYGWAAAC	MTDH	61	Q86UE4
LFGGFSILLWIGAIL	ATP1A3	86	P13637
ALIWGCKGLLLLYGA	GPR156	226	Q8NFN8
YLLENGLNLFLWVGA	SEC24C	981	P53992
GLVSKAGWLIGYILI	SLC22A2	211	O15244
AWALGVLLFCLLTGY	SBK2	246	P0C263
LFVAGLLGLIPVSWY	CLDN23	121	Q96B33
LLGLIPVSWYNHFLG	CLDN23	126	Q96B33
LFYGFLKPWLGDGLL	CYP4F22	131	Q6NT55
LWGLLFLGCRQYLSL	OR9A2	81	Q8NGT5
LLAGGLGLFLSYVWK	TMEM140	126	Q9NV12
LWGLQKGLAAGLLYQ	SLC25A34	66	Q6PIV7
NTWGLFLLVLLLGYG	LMBRD2	191	Q68DH5
LGGGYQKTLVLLTWI	SLC22A23	91	A1A5C7
LYQFAGGWTLLGSDL	OR56A3	201	Q8NH54
VWLLGLLYFSSLPLG	RNF182	186	Q8N6D2
WLLGRIFALLLGNLY	TMC1	441	Q8TDI8
LGYGWLEAIIFLIGI	ATP1A4	321	Q13733
IWLLASLIGGPALYF	CMKLR2	161	P46091
LIIFFWGVLGNGLSI	CYSLTR2	46	Q9NS75
ILGYFLTYWLLGLLL	PIGV	471	Q9NUD9
RWLFIGLAVAGLIYL	SLC7A11	396	Q9UPY5
PLILLYGLSLALGWN	UNC50	231	Q53HI1
NLGGLLLQALLEYWP	WDR48	461	Q8TAF3
LVLSLLGIQLAWGFY	TCTA	46	P57738
WNLLYGSLLLGLVGG	SLC12A9	166	Q9BXP2
LWLCLGLLDGLVSGY	FLT4	11	P35916
GVLLLGYGYFWLLVP	SLC50A1	106	Q9BRV3
GLLLLLLGLGACYTW	SIGLEC1	1651	Q9BZZ2
GILGAAIDYWIFLGL	SLF1	621	Q9BQI6
AGALVVYWLLSLLLG	TMEM109	136	Q9BVC6
LHALFYLFWLLVGGL	YIPF3	241	Q9GZM5
GRYLWAALVLALLGL	XKR8	41	Q9H6D3
GLGSSVIYFLWNLLL	XKR8	196	Q9H6D3