Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontau-protein kinase activity

BRSK2 TTBK2

1.21e-0422152GO:0050321
GeneOntologyMolecularFunctiontau protein binding

BRSK2 TTBK2

5.35e-0446152GO:0048156
GeneOntologyBiologicalProcessenteric nervous system development

SOX10 SOX8

3.88e-0514142GO:0048484
GeneOntologyBiologicalProcessatrial septum development

ZFPM1 ANK2

1.27e-0425142GO:0003283
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

ATXN1L SOX10 PHC3 YY1AP1 ZFPM1 SOX8

1.80e-041399146GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

ATXN1L SOX10 PHC3 YY1AP1 ZFPM1 SOX8

1.90e-041413146GO:1902679
DomainSox_N

SOX10 SOX8

1.56e-063142IPR022151
DomainSox_N

SOX10 SOX8

1.56e-063142PF12444
DomainHMG_box

SOX10 SOX8

7.03e-0453142PF00505
DomainHMG

SOX10 SOX8

7.30e-0454142SM00398
DomainHMG_BOX_2

SOX10 SOX8

7.30e-0454142PS50118
Domain-

SOX10 SOX8

7.57e-04551421.10.30.10
DomainHMG_box_dom

SOX10 SOX8

1.06e-0365142IPR009071
DomainAnk_2

PPP1R12C ANK2

1.10e-02215142PF12796
DomainAnk

PPP1R12C ANK2

1.23e-02228142PF00023
Domain-

PPP1R12C ANK2

1.44e-022481421.25.40.20
DomainANK

PPP1R12C ANK2

1.47e-02251142SM00248
DomainANK_REPEAT

PPP1R12C ANK2

1.49e-02253142PS50088
DomainAnkyrin_rpt-contain_dom

PPP1R12C ANK2

1.51e-02254142IPR020683
DomainANK_REP_REGION

PPP1R12C ANK2

1.51e-02254142PS50297
DomainAnkyrin_rpt

PPP1R12C ANK2

1.60e-02262142IPR002110
DomainS_TKc

BRSK2 TTBK2

2.88e-02359142SM00220
DomainPROTEIN_KINASE_ST

BRSK2 TTBK2

2.92e-02362142PS00108
DomainProtein_kinase_ATP_BS

BRSK2 TTBK2

3.18e-02379142IPR017441
DomainPkinase

BRSK2 TTBK2

3.21e-02381142PF00069
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

PHC3 ZFPM1 KMT2B

2.57e-04153123MM15522
PathwayWP_OLIGODENDROCYTE_SPECIFICATION_AND_DIFFERENTIATION_LEADING_TO_MYELIN_COMPONENTS_FOR_CNS

SOX10 SOX8

2.85e-0430122M39775
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

ZFPM1 KMT2B

6.16e-0444122MM15527
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

PHC3 ZFPM1 KMT2B

9.23e-04237123M27786
Pubmed

Transcription Factors Sox8 and Sox10 Contribute with Different Importance to the Maintenance of Mature Oligodendrocytes.

SOX10 SOX8

1.74e-07215239201442
Pubmed

Expression of connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor.

SOX10 SOX8

1.74e-07215216822525
Pubmed

The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism.

SOX10 SOX8

5.21e-07315231194875
Pubmed

Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.

SOX10 SOX8

5.21e-07315218512230
Pubmed

SOXE group transcription factors regulates the expression of FoxG1 during inner ear development.

SOX10 SOX8

1.04e-06415235878429
Pubmed

Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect.

SOX10 SOX8

1.73e-06515215572147
Pubmed

Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.

SOX10 ANK2

2.60e-06615231142747
Pubmed

Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse.

SOX10 SOX8

2.60e-06615215878625
Pubmed

The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina.

SOX10 SOX8

3.64e-06715219490914
Pubmed

Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes.

SOX10 SOX8

3.64e-06715229023979
Pubmed

Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy.

SOX10 SOX8

4.85e-06815215102707
Pubmed

Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.

SOX10 SOX8

6.24e-06915226546974
Pubmed

Phenotypes of neural-crest-derived cells in vagal and sacral pathways.

SOX10 SOX8

7.80e-061015216133146
Pubmed

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.

BRSK2 MUC5AC

9.53e-061115224429156
Pubmed

Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development.

SOX10 SOX8

1.14e-051215219933217
Pubmed

Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.

SOX10 SOX8

1.14e-05121527590241
Pubmed

Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.

SOX10 SOX8

1.14e-051215211071752
Pubmed

SoxE proteins are differentially required in mouse adrenal gland development.

SOX10 SOX8

1.14e-051215218272785
Pubmed

SOX9 induces and maintains neural stem cells.

SOX10 SOX8

1.14e-051215220871603
Pubmed

Seven new members of the Sox gene family expressed during mouse development.

SOX10 SOX8

1.35e-05131528441686
Pubmed

Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.

SOX10 SOX8

1.58e-05141528921394
Pubmed

Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord.

SOX10 SOX8

1.82e-051515215893981
Pubmed

Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.

SOX10 SOX8

1.82e-051515220144603
Pubmed

Analysis of the human SOX10 mutation Q377X in mice and its implications for genotype-phenotype correlation in SOX10-related human disease.

SOX10 SOX8

1.82e-051515229361054
Pubmed

Differential isoform expression and alternative splicing in sex determination in mice.

SOX10 SOX8

1.82e-051515230871468
Pubmed

Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice.

SOX10 SOX8

1.82e-051515222837482
Pubmed

Schwann cell precursors represent a neural crest-like state with biased multipotency.

SOX10 SOX8

2.35e-051715235815410
Pubmed

Spatio-temporal expression of Sox genes in murine palatogenesis.

SOX10 SOX8

2.35e-051715227241892
Pubmed

Expression of Sox genes in tooth development.

SOX10 SOX8

2.65e-051815226864488
Pubmed

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.

SOX10 MUC5AC

2.65e-051815217522155
Pubmed

Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.

SOX10 SOX8

2.65e-051815216790476
Pubmed

XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes.

SOX10 SOX8

3.28e-052015221466799
Pubmed

Sox9 is required for invagination of the otic placode in mice.

SOX10 SOX8

3.28e-052015218377888
Pubmed

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.

SOX10 SOX8

3.28e-052015233127760
Pubmed

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

SOX10 SOX8

3.63e-052115216306355
Pubmed

Expression of Sox transcription factors in the developing mouse pancreas.

SOX10 SOX8

3.63e-052115212815626
Pubmed

Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.

SOX10 SOX8

3.63e-052115223300469
Pubmed

SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function.

SOX10 SOX8

3.99e-052215217084361
Pubmed

Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum.

SOX10 SOX8

3.99e-052215225888505
Pubmed

The Sox9 transcription factor determines glial fate choice in the developing spinal cord.

SOX10 SOX8

4.37e-052315212842915
Pubmed

Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.

SOX10 SOX8

4.77e-052415217537790
Pubmed

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.

SOX10 SOX8

4.77e-052415216582099
Pubmed

Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation.

SOX10 ANK2

5.18e-052515232266943
Pubmed

SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.

SOX10 SOX8

8.02e-053115219723505
Pubmed

Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1.

SOX10 SOX8

8.55e-053215225725066
Pubmed

NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1.

SOX10 SOX8

8.55e-053215220610746
Pubmed

Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis.

SOX10 SOX8

1.08e-043615238078651
Pubmed

TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells.

SOX10 MRC1

1.27e-043915235781329
Pubmed

Roles of tau protein in health and disease.

BRSK2 TTBK2

1.34e-044015228386764
Pubmed

SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.

SOX10 SOX8

1.41e-044115228118982
Pubmed

Human transcription factor protein interaction networks.

ATXN1L SOX10 PHC3 YY1AP1 KMT2B

2.47e-04142915535140242
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

PHC3 YY1AP1 ZFPM1 KMT2B

2.73e-0477415415302935
InteractionPRRX2 interactions

SOX10 SOX8

7.74e-066152int:PRRX2
InteractionFEV interactions

ATXN1L PHC3 YY1AP1 KMT2B

1.25e-05203154int:FEV
InteractionUTF1 interactions

SOX10 SOX8

2.32e-0510152int:UTF1
InteractionPRRX1 interactions

SOX10 SOX8

7.86e-0518152int:PRRX1
InteractionPOU3F3 interactions

SOX10 SOX8

1.18e-0422152int:POU3F3
InteractionOLIG2 interactions

SOX10 SOX8

1.54e-0425152int:OLIG2
InteractionATXN1L interactions

ATXN1L SOX10 YY1AP1

1.72e-04150153int:ATXN1L
InteractionDLX5 interactions

SOX10 SOX8

2.08e-0429152int:DLX5
InteractionEGR2 interactions

ATXN1L SOX10 SOX8

2.53e-04171153int:EGR2
InteractionHOXC4 interactions

SOX10 SOX8

4.38e-0442152int:HOXC4
InteractionERG interactions

ATXN1L SOX10 FAM218A

5.51e-04223153int:ERG
InteractionNFIX interactions

ATXN1L SOX10 KMT2B

5.81e-04227153int:NFIX
InteractionPAX3 interactions

SOX10 SOX8

6.71e-0452152int:PAX3
InteractionYY1AP1 interactions

ATXN1L YY1AP1

6.71e-0452152int:YY1AP1
InteractionHHEX interactions

SOX10 SOX8

7.24e-0454152int:HHEX
Cytoband11p15.5

BRSK2 MUC5AC

6.73e-0411815211p15.5
CytobandEnsembl 112 genes in cytogenetic band chr11p15

BRSK2 MUC5AC

1.42e-02564152chr11p15
GeneFamilySRY-boxes

SOX10 SOX8

3.75e-051992757
GeneFamilyAnkyrin repeat domain containing

PPP1R12C ANK2

6.04e-0324292403
ToppCellBronchial-10x5prime-Stromal-Schwann|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SOX10 SOX8 ANK2

2.02e-05162153afffecc6c504930554aafc12c5bffa53e3c5b016
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8 ANK2

2.81e-051811531aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCellPCW_10-12-Neuronal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8 ANK2

2.81e-05181153381b553e2cae65ce6be100662a5f9f963353840c
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8 ANK2

2.81e-051811536aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCellPCW_13-14-Neuronal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BRSK2 SOX10 SOX8

2.95e-0518415365cf3460125e3dbc34978957bc138a449f71f7df
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BRSK2 SOX10 SOX8

3.00e-0518515356c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 SOX10 ANK2

3.56e-05196153e874aa82a20bb59582c8cd7f8d30b2ed02903a85
ToppCellBronchial-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SOX10 SOX8 ANK2

3.56e-05196153a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCellBronchial-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SOX10 SOX8 ANK2

3.62e-051971534a7ff67bb0754e034e6f2a1bd34cde86ee3ef899
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 SOX8 ANK2

3.67e-05198153731a90f7e68b19e387499d63e3979af78b503b0c
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 SOX8 ANK2

3.67e-0519815327f0654fb0857e93f030e1a4b1c307b31576bbcd
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX10 SOX8 ANK2

3.73e-051991535d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX10 SOX8 ANK2

3.73e-051991531bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX10 SOX8 ANK2

3.73e-051991539dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SOX10 SOX8 ANK2

3.73e-051991536fb5f931e6217142de38c1fffc011e63bda4772b
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

MUC5AC ZFPM1

5.77e-04107152d694e72244d0b79be7e47c393c06aa55d504aba8
ToppCellTCGA-Stomach|World / Sample_Type by Project: Shred V9

MUC5AC ZFPM1

5.77e-04107152f35fa6b05aacfd0bd6a8f9d5dbdd4a66212cc3cf
ToppCellBronchial-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SOX10 ANK2

6.77e-04116152b0a3c109c5f20ab699e53bf8ab3903d102f5f315
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BRSK2 SOX10

6.77e-04116152a07f16917c66ce25f23ebef350d693cc4c324075
ToppCelldroplet-Skin-nan-18m-Epithelial-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX8 ANK2

7.48e-04122152c7e81504e62d132624ec15b7d38dc5b6493a37a4
ToppCelldroplet-Skin-nan-18m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX8 ANK2

7.48e-041221528f675dc341b3f6e22f7e52c34d167d9e37df0982
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

MUC5AC ZFPM1

7.85e-04125152b82ce58b6262b0739c788395766e5fc77d2744f2
ToppCelldroplet-Skin-nan-18m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX8 ANK2

7.85e-041251525a309ce803d2b8efd791eb21808121bf5fc3ea8e
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Proliferative_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BRSK2 SOX10

8.36e-041291520dcce7cb95bb3593626ecb34ed9da58c7de4e016
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_-_proliferative|E16.5-samps / Age Group, Lineage, Cell class and subclass

TTBK2 ANK2

9.28e-0413615296370f0e3abf1c9ec7a91595b5d0f97ac2ab4b78
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-OPC_Pdgfra_Grm5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOX10 SOX8

9.69e-04139152a957ea4e581646c76b16b6a7f89579b8c7ac35b6
ToppCellEntopeduncular-Macroglia-POLYDENDROCYTE|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.07e-03146152a317f14a1aab11ffcce65baeb1c475c04324315f
ToppCellSerous|World / shred by cell class for turbinate

SOX10 SOX8

1.13e-031501526a326662d58b0f17d6efa8cc28571f4cbbf57c2d
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.13e-0315015270ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

MUC5AC ZFPM1

1.14e-031511523dfa1d89975ffaa45b26833538244153d50c60a7
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

MUC5AC ZFPM1

1.14e-0315115260bb6de5d9b13402bc18cb6d5e51078326dff8e2
ToppCellControl-CD8+_T|World / Disease group and Cell class

MRC1 ZFPM1

1.28e-03160152f5151f5cf1a4a4a997496e03e48293e4c751d077
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BRSK2 SOX10

1.30e-03161152bb9cb42882aaa4a1ecf9b480c0e7ac302f2c0d5d
ToppCellControl|World / Disease group and Cell class

MRC1 ZFPM1

1.30e-03161152e3e72cda7cc70f06d669f26ccf06d51346d7136f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX10 SOX8

1.31e-03162152d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX10 SOX8

1.31e-031621525bbd7130d4dad9035e73a439dda568195c136f31
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX10 SOX8

1.31e-03162152eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX10 SOX8

1.31e-03162152e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTBK2 KMT2B

1.33e-03163152953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

SOX8 ANK2

1.38e-03166152c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCellPosterior_cortex-Macroglia-POLYDENDROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.38e-03166152a7ac5a414e3e2ff01f1c452c0a85048b17cba0b6
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.39e-0316715249b19159c62d33d65ed1e59a148c11ae902fd41c
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.39e-0316715217c653b46507c8bb85da95836ae72a6015336142
ToppCellThalamus-Macroglia-POLYDENDROCYTE|Thalamus / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.39e-031671521e144c03409df94ccd39760842590e8ea7487e29
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MRC1 ZFPM1

1.39e-03167152a48349f189f6a8d563744b0a294c3974f3a18f50
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.41e-03168152af82e07d1eec51fc6530155f37addbce6221885d
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 KMT2B

1.41e-03168152ca65321259711321c175ede67bd67a47aad81d7a
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

TTBK2 YY1AP1

1.41e-03168152c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

SOX10 ANK2

1.41e-0316815288c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ANK2

1.43e-031691523f8aa6d2f9aa060ae1a0ea3eb47e794099fc2c2c
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRSK2 SOX10

1.43e-03169152d18b823836ca6fba79a2d2f10cb9966fa2623af2
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRSK2 SOX10

1.43e-03169152befb9b1618ea30fbf8983bcc493853da53b809c3
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ANK2

1.43e-0316915226de495c7562e0740689d0f78e803698e3e793db
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Microfold_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MUC5AC SOX8

1.43e-03169152a54a8494c1feff29d77ab4737fcfabc84ace5c94
ToppCellFrontal_cortex-Macroglia-POLYDENDROCYTE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.43e-0316915250cc0f5a022b95986949db63208a627cef9f4a69
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage|390C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 ZFPM1

1.44e-031701523a7121d045f9ae54583b0f5f7436abf3665a1bce
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ANK2

1.44e-03170152670027daec5a10dfa12246f1497b58db21d32a22
ToppCelldroplet-Lung-nan-18m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5AC SOX8

1.44e-03170152749144a1a869a6bf9acdd227184319083367dc3f
ToppCelldroplet-Lung-nan-18m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5AC SOX8

1.44e-0317015225d60a62e8f99c31ab64fe6a0c07ccca3df1a7ee
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MUC5AC SOX8

1.48e-03172152422d311bba2dd5d8bece4e96ee8c86e78086b62d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-plasmacytoid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MUC5AC SOX8

1.48e-031721521abb6fbb28c8aff384540493d0f70eeacaa751f4
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MUC5AC SOX8

1.49e-031731524f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCellFrontal_cortex-Macroglia|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.49e-03173152ac70145e093ef0df43811e7c67a865ccdd45a5e3
ToppCelldroplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MUC5AC SOX8

1.49e-031731529bbea566964281f47bf75d665b7d69ba8326e207
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

SOX10 ANK2

1.49e-031731526fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.49e-0317315223e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCellwk_20-22-Epithelial-PNS|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.49e-0317315217b1a6b0318925d5d920f2c0a791745b9587ebef
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.51e-031741521463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.51e-03174152c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCell5'-GW_trimst-2-LymphNode-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.51e-03174152d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCellPCW_13-14-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.51e-031741520d8e737860120dcd3a6b57992c612595904d585e
ToppCellSubstantia_nigra-Macroglia|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.51e-031741527e7f7ca9a413ec255e54621800a279c771b9e6b7
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.51e-03174152412ccc099028a372b9d953363984c2da54b2187f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 SOX8

1.53e-031751529a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 SOX8

1.53e-031751522b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCellPosterior_cortex-Macroglia|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.53e-031751528bc7a3856d04692989b2a1675ea6d9392261d55a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 SOX8

1.53e-0317515254c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 MRC1

1.53e-031751529d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX10 MRC1

1.53e-03175152f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 ZFPM1

1.53e-0317515243be63976da5ad0764d24d90919a77ce46068f52
ToppCellwk_20-22-Epithelial-PNS-Late_Schwann|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

BRSK2 SOX10

1.55e-0317615281924471d8a8c5bd8eedf294c007e25b6cd3e417
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

BRSK2 SOX10

1.56e-0317715259cf56c385c324f0844f20003d2b5049a2791e45
ToppCellPCW_13-14-Neuronal-Neuronal_SCP|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.56e-03177152621dd82f1393c961d4dd7a615aa52c9df9e36336
ToppCellwk_15-18-Epithelial-PNS-Schwann_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.56e-031771525357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.56e-031771528c78f7de091f16e86e326a73c9f1429e0232821f
ToppCellILEUM-inflamed-(9)_Enteric_neurons|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SOX10 ANK2

1.58e-03178152d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCelldroplet-Heart-4Chambers-21m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRSK2 SOX10

1.58e-031781523e8aacb27ed1a3c3978e21dddddd0828f8000692
ToppCellILEUM-inflamed-(9)_Neuro_cell|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SOX10 ANK2

1.58e-03178152611504b0a9e6318b18fba83787b03f9245c82252
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.58e-03178152b1357ceb84b83fab53c0394c1af73cbd009f571a
ToppCellPCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BRSK2 SOX10

1.58e-0317815238ffbd01230c99f52274424ee6c172381daffc73
ToppCellwk_08-11-Epithelial-PNS-Proliferating_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SOX10 SOX8

1.60e-03179152ab23fee9adab1e63d5b5cd9faba6b9a92beef425
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BRSK2 SOX10

1.60e-03179152df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCellGlobus_pallidus-Macroglia|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.60e-03179152ab50f711b004b96107f813c9a2526ec21d1c8027
ToppCellEntopeduncular-Macroglia|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.60e-03179152f61974710a60aa0618fdb30d864fb9bc7c05ef21
ToppCell5'-Adult-SmallIntestine-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 ANK2

1.62e-03180152ebd6e719a03f25155fa8181be19469d04d6d10a6
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.62e-0318015238490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCell5'-Adult-SmallIntestine-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 ANK2

1.62e-031801525e6e38ee0758ef2342a6a821c78ed24b57bb7b11
ToppCell5'-Adult-SmallIntestine-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 ANK2

1.62e-03180152b88cd7ae922782176c057342d1b9eb9b8e5e7204
ToppCellThalamus-Macroglia|Thalamus / BrainAtlas - Mouse McCarroll V32

SOX10 SOX8

1.63e-031811524f62b63854a4e9fea6e839f0340e78392c66fb0e
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX10 SOX8

1.63e-03181152098dbb3e0ff531c9720a233123250c1e39a97d4c
DiseaseAtaxia, Spinocerebellar

ATXN1L TTBK2

1.34e-0434152C0087012
DiseaseSpinocerebellar Ataxia Type 2

ATXN1L TTBK2

1.34e-0434152C0752121
DiseaseSpinocerebellar Ataxia Type 1

ATXN1L TTBK2

1.34e-0434152C0752120
DiseaseSpinocerebellar Ataxia Type 5

ATXN1L TTBK2

1.34e-0434152C0752123
DiseaseSpinocerebellar Ataxia Type 7

ATXN1L TTBK2

1.34e-0434152C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

ATXN1L TTBK2

1.34e-0434152C0752124
DiseaseSpinocerebellar Ataxia Type 4

ATXN1L TTBK2

1.42e-0435152C0752122
DiseaseNeurodevelopmental Disorders

BRSK2 ANK2

1.00e-0393152C1535926
Diseaseeosinophil percentage of leukocytes

MUC5AC ZFPM1 KMT2B

5.84e-03746153EFO_0007991

Protein segments in the cluster

PeptideGeneStartEntry
EKVKPPPSPTTEGPS

AKAP2

771

Q9Y2D5
HPPVSPSGKTDKRPP

ANK2

1901

Q01484
PDKEPTPPPITSSHL

ATXN1L

451

P0C7T5
LPTPKGTPVHTPKES

BRSK2

441

Q8IWQ3
VTPPKLPGHSKSEGP

FAM218A

106

Q96MZ4
STPGHPVKKEPAEPT

ZFPM1

196

Q8IX07
EPPPPVVPVKHQTGS

KMT2B

251

Q9UMN6
PPKTVATTRPTPHPT

MUC5AC

2056

P98088
IKSPSDPSHVSVPPP

PHC3

651

Q8NDX5
TGVSHLSPEPPKTPV

FAM47A

206

Q5JRC9
GVTHPPKPTTTPEPK

MRC1

631

P22897
GVSSPPHPSPKSPVQ

PPP1R12C

396

Q9BZL4
THGPPTPPTTPKTEL

SOX8

221

P57073
TGPPRPHIKTEQPSP

SOX8

331

P57073
PGSPHNPKTPPKSPV

TTBK2

1131

Q6IQ55
HGPPTPPTTPKTELQ

SOX10

236

P56693
TVFPKVEHSPGPPPV

YY1AP1

716

Q9H869