Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnuclear migration

DOCK7 CDC42BPA FHOD1

2.58e-0534353GO:0007097
GeneOntologyBiologicalProcessnucleus localization

DOCK7 CDC42BPA FHOD1

5.65e-0544353GO:0051647
DomainREKLES_domain

ARID3C ARID3B

1.02e-053352IPR023334
DomainREKLES

ARID3C ARID3B

1.02e-053352PS51486
Domain-

ARID3C ARID3B

3.53e-04153521.10.150.60
DomainARID

ARID3C ARID3B

3.53e-0415352PF01388
DomainBRIGHT

ARID3C ARID3B

3.53e-0415352SM00501
DomainARID_dom

ARID3C ARID3B

3.53e-0415352IPR001606
DomainARID

ARID3C ARID3B

3.53e-0415352PS51011
Domain-

SHC1 ACAP1 CDC42BPA PREX2

5.93e-033913542.30.29.30
DomainEF_HAND_1

CIB2 CABP5 TBC1D8B

6.50e-03204353PS00018
DomainPH_dom-like

SHC1 ACAP1 CDC42BPA PREX2

7.99e-03426354IPR011993
DomainPH

ACAP1 CDC42BPA PREX2

8.92e-03229353PF00169
DomainEF_HAND_2

CIB2 CABP5 TBC1D8B

9.13e-03231353PS50222
DomainEF_hand_dom

CIB2 CABP5 TBC1D8B

9.24e-03232353IPR002048
PathwayBIOCARTA_PTEN_PATHWAY

SHC1 MAPK3 PDK2

5.61e-0618283M10145
PathwayBIOCARTA_PTEN_PATHWAY

SHC1 MAPK3 PDK2

5.61e-0618283MM1461
PathwayPID_ERBB2_ERBB3_PATHWAY

SHC1 DOCK7 MAPK3

8.80e-0544283M175
PathwayREACTOME_SIGNAL_ATTENUATION

SHC1 MAPK3

1.70e-0410282M14236
PathwayREACTOME_SIGNAL_ATTENUATION

SHC1 MAPK3

1.70e-0410282MM15440
PathwayBIOCARTA_ERK5_PATHWAY

SHC1 MAPK3

3.41e-0414282MM1481
PathwayBIOCARTA_ERK5_PATHWAY

SHC1 MAPK3

3.41e-0414282M16811
PathwayBIOCARTA_IL3_PATHWAY

SHC1 MAPK3

3.93e-0415282MM1412
PathwayBIOCARTA_IL3_PATHWAY

SHC1 MAPK3

3.93e-0415282M17681
PathwayBIOCARTA_SPRY_PATHWAY

SHC1 MAPK3

4.49e-0416282MM1500
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

SHC1 MAPK3

4.49e-0416282M39882
PathwayBIOCARTA_SPRY_PATHWAY

SHC1 MAPK3

5.08e-0417282M1389
PathwaySA_PTEN_PATHWAY

SHC1 MAPK3

5.08e-0417282M12771
PathwayWP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION

MAPK3 CDH16

6.37e-0419282M39370
PathwayBIOCARTA_ECM_PATHWAY

SHC1 MAPK3

6.37e-0419282M6355
PathwayBIOCARTA_EPO_PATHWAY

SHC1 MAPK3

6.37e-0419282M12836
PathwayBIOCARTA_EPO_PATHWAY

SHC1 MAPK3

7.07e-0420282MM1389
PathwayBIOCARTA_NGF_PATHWAY

SHC1 MAPK3

7.07e-0420282M7860
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

CREB3L3 MAPK3

7.81e-0421282M47792
PathwayBIOCARTA_IGF1_PATHWAY

SHC1 MAPK3

7.81e-0421282M2623
PathwayBIOCARTA_ECM_PATHWAY

SHC1 MAPK3

7.81e-0421282MM1390
PathwayBIOCARTA_IL6_PATHWAY

SHC1 MAPK3

7.81e-0421282M5489
PathwayBIOCARTA_INSULIN_PATHWAY

SHC1 MAPK3

7.81e-0421282M765
PathwayBIOCARTA_IL2_PATHWAY

SHC1 MAPK3

8.57e-0422282M7747
PathwayBIOCARTA_IGF1_PATHWAY

SHC1 MAPK3

8.57e-0422282MM1409
PathwayBIOCARTA_IL6_PATHWAY

SHC1 MAPK3

8.57e-0422282MM1415
PathwayBIOCARTA_IGF1R_PATHWAY

SHC1 MAPK3

8.57e-0422282MM1438
PathwayBIOCARTA_NGF_PATHWAY

SHC1 MAPK3

8.57e-0422282MM1440
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

CREB3L3 MAPK3

9.38e-0423282M47799
PathwayBIOCARTA_EIF4_PATHWAY

MAPK3 PDK2

9.38e-0423282MM1470
PathwayBIOCARTA_HER2_PATHWAY

SHC1 MAPK3

9.38e-0423282MM1480
PathwayBIOCARTA_IL2_PATHWAY

SHC1 MAPK3

9.38e-0423282MM1411
PathwayBIOCARTA_HER2_PATHWAY

SHC1 MAPK3

9.38e-0423282M18719
PathwayBIOCARTA_IGF1R_PATHWAY

SHC1 MAPK3

9.38e-0423282M19613
PathwaySA_B_CELL_RECEPTOR_COMPLEXES

SHC1 MAPK3

1.02e-0324282M17200
PathwayBIOCARTA_INSULIN_PATHWAY

SHC1 MAPK3

1.02e-0324282MM1425
PathwayBIOCARTA_EIF4_PATHWAY

MAPK3 PDK2

1.02e-0324282M4791
PathwayBIOCARTA_TPO_PATHWAY

SHC1 MAPK3

1.02e-0324282M11520
PathwayBIOCARTA_TFF_PATHWAY

SHC1 MAPK3

1.02e-0324282M15926
PathwayBIOCARTA_TPO_PATHWAY

SHC1 MAPK3

1.11e-0325282MM1519
PathwayPID_LYMPH_ANGIOGENESIS_PATHWAY

SHC1 MAPK3

1.11e-0325282M274
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

SHC1 MAPK3

1.11e-0325282M39713
PathwayBIOCARTA_AT1R_PATHWAY

SHC1 MAPK3

1.20e-0326282MM1346
PathwayWP_EPO_RECEPTOR_SIGNALING

SHC1 MAPK3

1.20e-0326282M39687
PathwayBIOCARTA_PYK2_PATHWAY

SHC1 MAPK3

1.20e-0326282MM1431
PathwayREACTOME_SIGNALLING_TO_ERKS

SHC1 MAPK3

1.20e-0326282MM14716
PathwayWP_EPO_RECEPTOR_SIGNALING

SHC1 MAPK3

1.20e-0326282MM15896
PathwayBIOCARTA_AT1R_PATHWAY

SHC1 MAPK3

1.29e-0327282M14899
PathwayBIOCARTA_ERK_PATHWAY

SHC1 MAPK3

1.29e-0327282M287
PathwayBIOCARTA_PYK2_PATHWAY

SHC1 MAPK3

1.29e-0327282M7739
PathwayBIOCARTA_GH_PATHWAY

SHC1 MAPK3

1.29e-0327282M9043
PathwayBIOCARTA_EGF_PATHWAY

SHC1 MAPK3

1.29e-0327282M1909
PathwaySIG_IL4RECEPTOR_IN_B_LYPHOCYTES

SHC1 MAPK3

1.29e-0327282M1718
PathwayBIOCARTA_EGF_PATHWAY

SHC1 MAPK3

1.39e-0328282MM1386
PathwayBIOCARTA_ERK_PATHWAY

SHC1 MAPK3

1.39e-0328282MM1391
PathwayBIOCARTA_PDGF_PATHWAY

SHC1 MAPK3

1.39e-0328282M2529
PathwayBIOCARTA_BIOPEPTIDES_PATHWAY

SHC1 MAPK3

1.49e-0329282MM1356
PathwayBIOCARTA_TFF_PATHWAY

SHC1 MAPK3

1.49e-0329282MM1522
PathwayBIOCARTA_PDGF_PATHWAY

SHC1 MAPK3

1.49e-0329282MM1452
PathwayBIOCARTA_BIOPEPTIDES_PATHWAY

SHC1 MAPK3

1.49e-0329282M13494
PathwayWP_PDGFRBETA_PATHWAY

SHC1 MAPK3

1.49e-0329282M39616
PathwayKEGG_MEDICUS_REFERENCE_PRNP_PI3K_NOX2_SIGNALING_PATHWAY

CREB3L3 MAPK3

1.49e-0329282M47764
PathwayBIOCARTA_BCR_PATHWAY

SHC1 MAPK3

1.82e-0332282MM1355
PathwayWP_ALPHA_6_BETA_4_SIGNALING

SHC1 MAPK3

1.93e-0333282M39503
PathwayBIOCARTA_BCR_PATHWAY

SHC1 MAPK3

1.93e-0333282M9494
PathwayBIOCARTA_GH_PATHWAY

SHC1 MAPK3

1.93e-0333282MM1404
PathwayBIOCARTA_INTEGRIN_PATHWAY

SHC1 MAPK3

1.93e-0333282MM1426
PathwayBIOCARTA_INTEGRIN_PATHWAY

SHC1 MAPK3

2.05e-0334282M3342
PathwayREACTOME_SIGNALLING_TO_ERKS

SHC1 MAPK3

2.05e-0334282M13881
PathwayPID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY

SHC1 MAPK3

2.17e-0335282M127
PathwayBIOCARTA_IL2RB_PATHWAY

SHC1 MAPK3

2.30e-0336282MM1418
PathwayPID_GMCSF_PATHWAY

SHC1 MAPK3

2.30e-0336282M22
PathwayBIOCARTA_IL2RB_PATHWAY

SHC1 MAPK3

2.43e-0337282M8615
PathwayPID_ERBB4_PATHWAY

SHC1 MAPK3

2.56e-0338282M13
PathwayREACTOME_SIGNALING_BY_FGFR3

SHC1 MAPK3

2.69e-0339282MM15257
PathwayPID_RET_PATHWAY

SHC1 MAPK3

2.69e-0339282M82
PathwayBIOCARTA_FCER1_PATHWAY

SHC1 MAPK3

2.69e-0339282MM1397
PathwayBIOCARTA_FCER1_PATHWAY

SHC1 MAPK3

2.69e-0339282M1908
PathwayREACTOME_SIGNALING_BY_FGFR3

SHC1 MAPK3

2.83e-0340282M27532
PathwayWP_PDGF_PATHWAY

SHC1 MAPK3

2.83e-0340282M39555
PathwayREACTOME_SIGNALING_BY_FGFR4

SHC1 MAPK3

2.83e-0340282MM15258
PathwayWP_IL5_SIGNALING

SHC1 MAPK3

2.83e-0340282M39392
PathwayPID_EPHB_FWD_PATHWAY

SHC1 MAPK3

2.83e-0340282M62
PathwayPID_ERBB1_INTERNALIZATION_PATHWAY

SHC1 ZFYVE28

2.97e-0341282M214
PathwayREACTOME_SIGNALING_BY_FGFR4

SHC1 MAPK3

2.97e-0341282M27533
PathwayWP_IL2_SIGNALING

SHC1 MAPK3

3.12e-0342282M39536
PathwayBIOCARTA_TCR_PATHWAY

SHC1 MAPK3

3.12e-0342282MM1504
PathwayWP_IL6_SIGNALING

SHC1 MAPK3

3.27e-0343282M39656
PathwayWP_IL7_SIGNALING_PATHWAY

SHC1 MAPK3

3.27e-0343282MM15864
PathwayBIOCARTA_TCR_PATHWAY

SHC1 MAPK3

3.42e-0344282M19784
PathwayREACTOME_CDC42_GTPASE_CYCLE

DOCK7 CDC42BPA PREX2

3.49e-03155283M41808
PathwaySIG_BCR_SIGNALING_PATHWAY

SHC1 MAPK3

3.73e-0346282M8626
PathwayREACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE

SHC1 MAPK3

4.06e-0348282MM15441
PathwayWP_IL3_SIGNALING

SHC1 MAPK3

4.22e-0349282M39722
PathwayPID_ANGIOPOIETIN_RECEPTOR_PATHWAY

SHC1 MAPK3

4.22e-0349282M92
PathwayREACTOME_SIGNALING_BY_FGFR1

SHC1 MAPK3

4.39e-0350282MM15255
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

SHC1 MAPK3

4.57e-0351282M7955
PathwayREACTOME_SIGNALING_BY_FGFR1

SHC1 MAPK3

4.74e-0352282M27530
PathwayPID_KIT_PATHWAY

SHC1 MAPK3

4.74e-0352282M231
PathwayREACTOME_RAC1_GTPASE_CYCLE

DOCK7 CDC42BPA PREX2

4.90e-03175283MM15599
Pubmed

Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway.

SHC1 MAPK3

2.95e-06335225217205
Pubmed

ARID proteins come in from the desert.

ARID3C ARID3B

2.95e-06335210838570
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

DOCK7 SFMBT1 CHD8 FAM193A ZNF532 BCORL1

3.51e-0641835634709266
Pubmed

Non-redundant role of Shc in Erk activation by cytoskeletal reorganization.

SHC1 MAPK3

5.90e-06435214576154
Pubmed

Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.

ARID3C ARID3B

5.90e-06435221955986
Pubmed

Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs.

STAB2 MAPK3

5.90e-06435227100626
Pubmed

Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).

SHC1 MAPK3

5.90e-06435222039050
Pubmed

Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.

SHC1 MAPK3

9.82e-0653528621459
Pubmed

The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases.

STAB2 MAPK3

9.82e-06535218387958
Pubmed

Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).

SHC1 MAPK3

1.47e-05635216614081
Pubmed

Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.

SHC1 MAPK3

1.47e-05635217417601
Pubmed

The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.

CHD8 MAPK3

1.47e-05635225219500
Pubmed

Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.

SHC1 MAPK3

1.47e-05635220442398
Pubmed

Insulin-stimulated disassociation of the SOS-Grb2 complex.

SHC1 MAPK3

1.47e-0563527739560
Pubmed

Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.

SHC1 MAPK3

2.06e-0573529325171
Pubmed

Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning.

SHC1 MAPK3

2.06e-05735215121188
Pubmed

Mek1Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome.

MAPK3 UCHL3

2.74e-05835229590634
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

DOCK7 CDC42BPA ADAR ARHGAP36 PREX2 UCHL3 ARID3B

3.03e-0591635732203420
Pubmed

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.

SHC1 MAPK3

3.53e-05935217938255
Pubmed

Nomenclature of the ARID family of DNA-binding proteins.

ARID3C ARID3B

4.40e-051035215922553
Pubmed

HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.

SHC1 MAPK3

6.45e-051235216436505
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ZFYVE28 CHD8 ZNF532

1.45e-0410135310997877
Pubmed

Nerve growth factor signaling, neuroprotection, and neural repair.

SHC1 MAPK3

3.15e-042635211520933
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

CHD8 BCORL1 ARID3B EFTUD2

3.66e-0433935430415952
Pubmed

SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.

ADAR EFTUD2

4.20e-043035234780058
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

CHD8 ADAR ARID3B EFTUD2

4.45e-0435735437059091
Pubmed

Yap and Taz are required for Ret-dependent urinary tract morphogenesis.

MAPK3 CDH16

4.49e-043135226243870
Pubmed

The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.

SHC1 MAPK3

4.49e-043135222508726
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

CHD8 CDC42BPA ARID3B EFTUD2

7.53e-0441135435182466
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MAPK3 ODF2 CARMIL1 FHOD1 EFTUD2

1.01e-0377435515302935
Cytoband15q24

CIB2 ARID3B

1.17e-042135215q24
Cytoband4p16.3

ZFYVE28 FAM193A

1.94e-03853524p16.3
GeneFamilyAT-rich interaction domain containing

ARID3C ARID3B

1.75e-0415242418
GeneFamilyEF-hand domain containing

CIB2 CABP5 TBC1D8B

2.94e-03219243863
DrugDS-201

CACNA2D1 MAPK3

2.30e-062352CID000125782
Diseasefactor VIII measurement

ABCC12 STAB2

1.04e-0340352EFO_0004630
DiseaseCardiomyopathies, Primary

MAPK3 PDK2

3.05e-0369352C0033141
DiseaseMyocardial Diseases, Secondary

MAPK3 PDK2

3.05e-0369352C0036529
Diseasecancer (implicated_via_orthology)

ACAP1 MAPK3 TOP1MT

3.91e-03268353DOID:162 (implicated_via_orthology)
Diseaseobsolete aging

CIB2 CREB3L3 CARMIL1

4.38e-03279353GO_0007568
DiseaseMechanical Allodynia

CACNA2D1 MAPK3

4.48e-0384352C2936719
DiseaseHyperalgesia

CACNA2D1 MAPK3

4.48e-0384352C0020429
DiseaseAllodynia

CACNA2D1 MAPK3

4.48e-0384352C0458247
DiseaseHyperalgesia, Secondary

CACNA2D1 MAPK3

4.48e-0384352C0751212
DiseaseHyperalgesia, Primary

CACNA2D1 MAPK3

4.48e-0384352C0751211
DiseaseHyperalgesia, Thermal

CACNA2D1 MAPK3

4.48e-0384352C0751214
DiseaseTactile Allodynia

CACNA2D1 MAPK3

4.48e-0384352C0751213
Diseaseserum iron measurement

GK2 CARMIL1

4.69e-0386352EFO_0006332

Protein segments in the cluster

PeptideGeneStartEntry
PERKEFLDDLFVFMQ

ARID3B

216

Q8IVW6
MDLFDDPNLFGLDSL

CHD8

6

Q9HCK8
SMDPIDSFELLDLLF

CREB3L3

16

Q68CJ9
DADPKRKEFLDDLFS

ARID3C

111

A6NKF2
EEDDFMFELSDKPLL

BCORL1

1666

Q5H9F3
FRDFSLMASDDPEKL

ACAP1

716

Q15027
FLPKDIDLDSVDMDE

FAM193A

1211

P78312
EFFRDMKDSLLPDDL

ARHGAP36

296

Q6ZRI8
LDRKVEDMSELFRPF

ZFYVE28

246

Q9HCC9
FDDFVELMTPKLLAE

CABP5

86

Q9NP86
DERMLRFLDDFESCP

GGACT

71

Q9BVM4
FTFAMELDDLPKERL

MAPK3

346

P27361
SLLDIMEFLDKDPED

PDK2

91

Q15119
SDEDLYKFLADMRRP

DOCK7

481

Q96N67
ALEDPLEFLDMAEIK

ADAR

286

P55265
DKELCDFFEIPMDLL

GK2

216

Q14410
FPRLLEAVEMEDDDF

CACNA2D1

951

P54289
PVSRAFEMEFDLDKA

CARMIL1

931

Q5VZK9
FEMEFDLDKALEEVP

CARMIL1

936

Q5VZK9
DSMEREIAEPLFDLK

FHOD1

791

Q9Y613
DADLEPAFRLMDFAI

CDH16

476

O75309
LENERLKASFAPMED

ODF2

506

Q5BJF6
LLEKADLDPSLDFMD

RSPH9

201

Q9H1X1
RFSKDMDELDVRLPF

ABCC12

911

Q96J65
LSKFEDRLPEDMARF

CDC42BPA

166

Q5VT25
FADFEDMIAKAPDFL

CIB2

166

O75838
DPMERLVSAFRDKFE

CHST9

281

Q7L1S5
MKTPDFDDLLAAFDI

ZNF532

6

Q9HCE3
KFMERDPDELRFNAI

UCHL3

211

P15374
FAKEDDPEKFREALL

TBC1D8B

131

Q0IIM8
MENKDPRDDLFDRLT

TOP1MT

391

Q969P6
LDRAMDKLEPTFESN

STAB2

501

Q8WWQ8
DEPLLFRFFSDEEME

PREX2

556

Q70Z35
FDEKYFLVEMDDLRP

SFMBT1

301

Q9UHJ3
DVSISKFFDDPMLLE

EFTUD2

946

Q15029
RDLFDMKPFEDALRV

SHC1

456

P29353