Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC10A3 SLC4A4 HCN2 SLC13A2 SLC23A1 SLC5A3

7.33e-131715311GO:0015081
GeneOntologyMolecularFunctiontransporter activity

ABCC1 SLC9A8 ABCB7 CLCN7 SLC34A1 ABCA13 SCN4A SCN5A SCN10A ABCC5 ATP10B SLC10A3 KCNMB3 SLC43A3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

3.55e-1112895320GO:0005215
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ABCC1 SLC9A8 CLCN7 SLC34A1 SCN4A SCN5A SCN10A ABCC5 SLC10A3 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

6.35e-117585316GO:0015318
GeneOntologyMolecularFunctiontransmembrane transporter activity

ABCC1 SLC9A8 ABCB7 CLCN7 SLC34A1 ABCA13 SCN4A SCN5A SCN10A ABCC5 SLC10A3 KCNMB3 SLC43A3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

6.87e-1111805319GO:0022857
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC10A3 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

1.81e-104655313GO:0046873
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCC1 SLC9A8 ABCB7 CLCN7 SLC34A1 ABCA13 ABCC5 SLC10A3 SLC4A4 SLC13A2 SLC23A1 LETM1 SLC5A3

2.47e-104775313GO:0022804
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC10A3 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

6.76e-096275313GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC9A8 CLCN7 SLC34A1 SCN4A SCN5A SCN10A SLC10A3 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

1.23e-087935314GO:0015075
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC10A3 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

1.34e-086645313GO:0008324
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC34A1 SLC10A3 SLC4A4 SLC13A2 SLC23A1 SLC5A3

7.28e-0881536GO:0015370
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC9A8 CLCN7 SLC34A1 SLC10A3 SLC4A4 SLC13A2 SLC23A1 LETM1 SLC5A3

7.66e-08296539GO:0015291
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN4A SCN5A SCN10A HCN2

6.33e-0726534GO:0005248
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC34A1 SLC10A3 SLC4A4 SLC13A2 SLC23A1 SLC5A3

7.21e-07119536GO:0015294
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC9A8 SLC34A1 SLC10A3 SLC4A4 SLC13A2 SLC23A1 LETM1 SLC5A3

1.19e-06301538GO:0022853
GeneOntologyMolecularFunctionsymporter activity

SLC34A1 SLC10A3 SLC4A4 SLC13A2 SLC23A1 SLC5A3

2.79e-06150536GO:0015293
GeneOntologyMolecularFunctionRab GDP-dissociation inhibitor activity

GDI1 GDI2

6.91e-062532GO:0005093
GeneOntologyMolecularFunctionABC-type transporter activity

ABCC1 ABCB7 ABCA13 ABCC5

8.58e-0649534GO:0140359
GeneOntologyMolecularFunctionsodium channel activity

SCN4A SCN5A SCN10A HCN2

1.09e-0552534GO:0005272
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCC1 ABCC5 SLC10A3 SLC43A3 SLC4A4 SLC13A2 SLC23A1

1.18e-05293537GO:0008514
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ABCC1 CLCN7 SLC34A1 ABCC5 SLC4A4

8.94e-05171535GO:0015103
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC1 ABCC5 SLC43A3

9.97e-0534533GO:0042910
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity involved in cardiac muscle cell action potential

SCN5A SCN10A

1.03e-046532GO:0086006
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC10A3 SLC13A2 SLC23A1

1.09e-0435533GO:0005343
GeneOntologyMolecularFunctionglutathione transmembrane transporter activity

ABCC1 ABCC5

1.44e-047532GO:0034634
GeneOntologyMolecularFunctionlipid transporter activity

ABCC1 ABCA13 ATP10B SLC10A3 SLC43A3

1.70e-04196535GO:0005319
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCC1 ABCB7 ABCA13 ABCC5

2.00e-04109534GO:0042626
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

ABCC1 SLC10A3 SLC43A3 SLC13A2 SLC23A1

2.18e-04207535GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

ABCC1 SLC10A3 SLC43A3 SLC13A2 SLC23A1

2.23e-04208535GO:0005342
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

ABCC1 ABCC5

2.46e-049532GO:0042937
GeneOntologyMolecularFunctionheme transmembrane transporter activity

ABCB7 ABCC5

2.46e-049532GO:0015232
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

ABCC1 ABCC5

3.07e-0410532GO:0043225
GeneOntologyMolecularFunctionnucleobase transmembrane transporter activity

SLC43A3 SLC23A1

3.74e-0411532GO:0015205
GeneOntologyMolecularFunctionantiporter activity

SLC9A8 CLCN7 SLC4A4 LETM1

4.92e-04138534GO:0015297
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCC1 ABCC5

7.10e-0415532GO:0008559
GeneOntologyMolecularFunctionefflux transmembrane transporter activity

ABCC1 ABCC5

8.10e-0416532GO:0015562
GeneOntologyMolecularFunctionoligopeptide transmembrane transporter activity

ABCC1 ABCC5

8.10e-0416532GO:0035673
GeneOntologyMolecularFunctioncarbohydrate:monoatomic cation symporter activity

SLC23A1 SLC5A3

9.16e-0417532GO:0005402
GeneOntologyMolecularFunctionGDP-dissociation inhibitor activity

GDI1 GDI2

9.16e-0417532GO:0005092
GeneOntologyMolecularFunctionlipid transmembrane transporter activity

ABCC1 SLC10A3 SLC43A3

9.63e-0473533GO:0170055
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCC1 ABCB7 ABCA13 ABCC5

1.27e-03178534GO:0015399
GeneOntologyMolecularFunctionsphingolipid transporter activity

ABCC1 ATP10B

1.27e-0320532GO:0046624
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CLCN7 SCN4A SCN5A SCN10A KCNMB3 HCN2

1.31e-03459536GO:0005216
GeneOntologyMolecularFunctionfatty acid transmembrane transporter activity

ABCC1 SLC43A3

1.69e-0323532GO:0015245
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

ABCC1 SLC10A3 SLC43A3

1.76e-0390533GO:0008028
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SCN4A SCN5A SCN10A KCNMB3 HCN2

2.12e-03343535GO:0005261
GeneOntologyMolecularFunctionmetal cation:proton antiporter activity

SLC9A8 LETM1

2.33e-0327532GO:0051139
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC23A1 SLC5A3

2.33e-0327532GO:0015145
GeneOntologyMolecularFunctionchannel activity

CLCN7 SCN4A SCN5A SCN10A KCNMB3 HCN2

2.59e-03525536GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CLCN7 SCN4A SCN5A SCN10A KCNMB3 HCN2

2.61e-03526536GO:0022803
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC23A1 SLC5A3

2.68e-0329532GO:0051119
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

ABCC1 ABCC5

3.46e-0333532GO:0072349
GeneOntologyMolecularFunctionvitamin transmembrane transporter activity

ABCC1 SLC23A1

4.11e-0336532GO:0090482
GeneOntologyMolecularFunctionPDZ domain binding

SLC34A1 SSTR2 HCN2

4.27e-03123533GO:0030165
GeneOntologyMolecularFunctionATP-dependent activity

ABCC1 MYO3A ABCB7 ABCA13 ABCC5 ATP10B

5.56e-03614536GO:0140657
GeneOntologyMolecularFunctioncarbohydrate transmembrane transporter activity

SLC23A1 SLC5A3

5.56e-0342532GO:0015144
GeneOntologyMolecularFunctionamide transmembrane transporter activity

ABCC1 ABCC5

5.56e-0342532GO:0042887
GeneOntologyMolecularFunctionmetal cation:monoatomic cation antiporter activity

SLC9A8 LETM1

5.82e-0343532GO:0140828
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCC1 ABCB7 ABCA13 ABCC5 ATP10B

6.17e-03441535GO:0016887
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC9A8 KCNMB3 HCN2

9.91e-03167533GO:0015079
GeneOntologyMolecularFunctionpotassium channel regulator activity

KCNMB3 SLC5A3

1.00e-0257532GO:0015459
GeneOntologyMolecularFunctiontransmembrane transporter binding

SCN5A SCN10A SLC5A3

1.07e-02172533GO:0044325
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

ABCC1 ABCC5

1.14e-0261532GO:1901682
GeneOntologyMolecularFunctiongated channel activity

CLCN7 SCN10A KCNMB3 HCN2

1.18e-02334534GO:0022836
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CLCN7 SCN10A HCN2

1.25e-02182533GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CLCN7 SCN10A HCN2

1.29e-02184533GO:0022832
GeneOntologyBiologicalProcesssodium ion transmembrane transport

SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC4A4 HCN2 SLC13A2 SLC23A1 SLC5A3

1.17e-102085310GO:0035725
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

ABCC1 SLC9A8 ABCB7 HTR2A CLCN7 SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

1.29e-0911155317GO:0034220
GeneOntologyBiologicalProcesssodium ion transport

SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC4A4 HCN2 SLC13A2 SLC23A1 SLC5A3

1.77e-092755310GO:0006814
GeneOntologyBiologicalProcessmetal ion transport

SLC9A8 ABCB7 HTR2A SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 ACE SLC23A1 LETM1 SLC5A3

2.26e-0910005316GO:0030001
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC9A8 ABCB7 HTR2A CLCN7 SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

2.88e-0910175316GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transport

ABCC1 SLC9A8 ABCB7 HTR2A CLCN7 SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 ACE SLC23A1 LETM1 SLC5A3

4.11e-0913745318GO:0006811
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC9A8 ABCB7 HTR2A SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

6.45e-099225315GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC9A8 ABCB7 HTR2A SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 SLC23A1 LETM1 SLC5A3

8.61e-099425315GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC9A8 ABCB7 HTR2A SLC34A1 SCN4A SCN5A SCN10A ABCC5 KCNMB3 SLC4A4 HCN2 SLC13A2 ACE SLC23A1 LETM1 SLC5A3

1.80e-0811575316GO:0006812
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN4A SCN5A SCN10A HCN2

2.15e-0636534GO:0086010
GeneOntologyBiologicalProcessneuronal action potential

SCN4A SCN5A SCN10A KCNMB3

2.07e-0563534GO:0019228
GeneOntologyBiologicalProcesssodium ion import across plasma membrane

SLC34A1 SCN5A HCN2

4.49e-0527533GO:0098719
GeneOntologyBiologicalProcessorganic anion transport

ABCC1 ABCC5 SLC10A3 SLC43A3 SLC4A4 SLC13A2 ACE SLC23A1

4.72e-05515538GO:0015711
GeneOntologyBiologicalProcesspotassium ion transport

SLC9A8 HTR2A SCN4A KCNMB3 HCN2 LETM1

6.79e-05272536GO:0006813
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN4A SCN5A SCN10A HCN2

7.38e-0587534GO:0086001
GeneOntologyBiologicalProcesstransport across blood-brain barrier

ABCC1 ABCC5 SLC4A4 SLC5A3

7.38e-0587534GO:0150104
GeneOntologyBiologicalProcessvascular transport

ABCC1 ABCC5 SLC4A4 SLC5A3

7.72e-0588534GO:0010232
GeneOntologyBiologicalProcesscarboxylic acid transport

ABCC1 ABCC5 SLC10A3 SLC43A3 SLC13A2 ACE SLC23A1

8.16e-05410537GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

ABCC1 ABCC5 SLC10A3 SLC43A3 SLC13A2 ACE SLC23A1

8.42e-05412537GO:0015849
GeneOntologyBiologicalProcesscirculatory system process

ABCC1 HTR2A SCN4A SCN5A SCN10A ABCC5 SLC4A4 ACE SLC5A3

9.39e-05733539GO:0003013
GeneOntologyBiologicalProcessbundle of His cell action potential

SCN5A SCN10A

1.35e-047532GO:0086043
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte signaling

SCN5A SCN10A

1.35e-047532GO:0086028
GeneOntologyBiologicalProcessaction potential

SCN4A SCN5A SCN10A KCNMB3 HCN2

1.64e-04201535GO:0001508
GeneOntologyBiologicalProcessodontogenesis of dentin-containing tooth

SLC34A1 SCN5A SCN10A MMP20

1.65e-04107534GO:0042475
GeneOntologyBiologicalProcessglutathione transmembrane transport

ABCC1 ABCC5

1.80e-048532GO:0034775
GeneOntologyBiologicalProcesstransmission of nerve impulse

SCN4A SCN5A SCN10A KCNMB3

1.97e-04112534GO:0019226
GeneOntologyBiologicalProcessheme transport

ABCB7 ABCC5

2.31e-049532GO:0015886
GeneOntologyBiologicalProcessvascular process in circulatory system

ABCC1 HTR2A ABCC5 SLC4A4 ACE SLC5A3

2.44e-04344536GO:0003018
GeneOntologyBiologicalProcessmembrane depolarization

SCN4A SCN5A SCN10A HCN2

2.64e-04121534GO:0051899
GeneOntologyBiologicalProcessregulation of atrial cardiac muscle cell membrane depolarization

SCN5A SCN10A

2.88e-0410532GO:0060371
GeneOntologyBiologicalProcesstripeptide transmembrane transport

ABCC1 ABCC5

2.88e-0410532GO:0035443
GeneOntologyBiologicalProcessimport across plasma membrane

ABCC1 SLC34A1 SCN5A HCN2 SLC5A3

3.06e-04230535GO:0098739
GeneOntologyBiologicalProcesscyclic nucleotide transport

ABCC1 ABCC5

3.51e-0411532GO:0070729
GeneOntologyBiologicalProcessglutathione transport

ABCC1 ABCC5

3.51e-0411532GO:0034635
GeneOntologyBiologicalProcessvitamin transport

ABCC1 ABCC5 SLC23A1

4.03e-0456533GO:0051180
GeneOntologyBiologicalProcessiron coordination entity transport

ABCB7 ABCC5

4.21e-0412532GO:1901678
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

SCN5A SCN10A

4.21e-0412532GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

SCN5A SCN10A

4.21e-0412532GO:0086016
GeneOntologyBiologicalProcesstripeptide transport

ABCC1 ABCC5

4.96e-0413532GO:0042939
GeneOntologyBiologicalProcessnucleobase transport

SLC43A3 SLC23A1

4.96e-0413532GO:0015851
GeneOntologyBiologicalProcessregulation of membrane depolarization

SCN5A SCN10A HCN2

5.19e-0461533GO:0003254
GeneOntologyBiologicalProcessregulation of membrane potential

SLC34A1 SCN4A SCN5A SCN10A KCNMB3 SLC4A4 HCN2

5.41e-04559537GO:0042391
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN4A SCN5A SCN10A

5.44e-0462533GO:0086002
GeneOntologyBiologicalProcessxenobiotic transport

ABCC1 ABCC5 SLC43A3

5.97e-0464533GO:0042908
GeneOntologyBiologicalProcessodontogenesis

SLC34A1 SCN5A SCN10A MMP20

6.12e-04151534GO:0042476
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

ABCC1 CLCN7 ABCC5 SLC4A4

6.43e-04153534GO:0098656
GeneOntologyBiologicalProcessbundle of His cell to Purkinje myocyte communication

SCN5A SCN10A

6.66e-0415532GO:0086069
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

SCN5A SCN10A

6.66e-0415532GO:0086067
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

ABCC1 ABCC5 SLC13A2 SLC23A1

8.14e-04163534GO:1905039
GeneOntologyBiologicalProcessoligopeptide transmembrane transport

ABCC1 ABCC5

8.60e-0417532GO:0035672
GeneOntologyBiologicalProcessorganic acid transmembrane transport

ABCC1 ABCC5 SLC13A2 SLC23A1

8.91e-04167534GO:1903825
GeneOntologyBiologicalProcessregulation of carbohydrate catabolic process

HTR2A HSD11B1 SLC4A4

1.23e-0382533GO:0043470
GeneOntologyBiologicalProcessmonoatomic anion transport

ABCC1 CLCN7 ABCC5 SLC4A4

1.25e-03183534GO:0006820
GeneOntologyBiologicalProcessresponse to thyroid hormone

SLC34A1 ACE

1.32e-0321532GO:0097066
GeneOntologyBiologicalProcessoligopeptide transport

ABCC1 ABCC5

1.58e-0323532GO:0006857
GeneOntologyBiologicalProcessmembrane depolarization during cardiac muscle cell action potential

SCN5A HCN2

1.58e-0323532GO:0086012
GeneOntologyBiologicalProcessvitamin transmembrane transport

ABCC5 SLC23A1

1.58e-0323532GO:0035461
GeneOntologyBiologicalProcessexport across plasma membrane

ABCC1 ABCC5 SLC4A4

1.66e-0391533GO:0140115
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN4A SCN5A SCN10A

1.77e-0393533GO:0086003
GeneOntologyBiologicalProcesslipid transport

ABCC1 ABCA13 ATP10B SLC10A3 SLC43A3 ACE

1.83e-03506536GO:0006869
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception of pain

HTR2A SCN10A

2.02e-0326532GO:0050965
GeneOntologyBiologicalProcesscardiac conduction

SCN5A SCN10A ACE

2.17e-03100533GO:0061337
GeneOntologyBiologicalProcessmonocarboxylic acid transport

ABCC1 SLC10A3 SLC43A3 ACE

2.18e-03213534GO:0015718
GeneOntologyBiologicalProcesspositive regulation of glycolytic process

HTR2A SLC4A4

2.52e-0329532GO:0045821
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide catabolic process

HTR2A SLC4A4

2.52e-0329532GO:0033123
GeneOntologyBiologicalProcesspositive regulation of nucleotide catabolic process

HTR2A SLC4A4

2.52e-0329532GO:0030813
GeneOntologyBiologicalProcessdetection of temperature stimulus involved in sensory perception

HTR2A SCN10A

2.69e-0330532GO:0050961
GeneOntologyBiologicalProcessiron ion transmembrane transport

ABCB7 ABCC5

2.69e-0330532GO:0034755
GeneOntologyCellularComponentbasal plasma membrane

ABCC1 SLC34A1 ABCC5 SLC43A3 SLC4A4 ACE SLC23A1 SLC5A3

2.85e-06354538GO:0009925
GeneOntologyCellularComponentbasal part of cell

ABCC1 SLC34A1 ABCC5 SLC43A3 SLC4A4 ACE SLC23A1 SLC5A3

4.62e-06378538GO:0045178
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN4A SCN5A SCN10A

1.02e-0517533GO:0001518
GeneOntologyCellularComponentcation channel complex

SCN4A SCN5A SCN10A KCNMB3 HCN2 SLC5A3

2.80e-05235536GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

CLCN7 SCN4A SCN5A SCN10A KCNMB3 HCN2 SLC5A3

4.51e-05378537GO:0034702
GeneOntologyCellularComponentsodium channel complex

SCN4A SCN5A SCN10A

5.37e-0529533GO:0034706
GeneOntologyCellularComponenttransporter complex

CLCN7 SCN4A SCN5A SCN10A ATP10B KCNMB3 HCN2 SLC5A3

6.82e-05550538GO:1990351
GeneOntologyCellularComponentapical part of cell

ABCC1 SLC9A8 SLC34A1 ABCC5 HSD11B1 SLC13A2 SLC23A1 SLC5A3

1.14e-04592538GO:0045177
GeneOntologyCellularComponentbasolateral plasma membrane

ABCC1 SLC34A1 ABCC5 SLC43A3 SLC4A4 SLC5A3

1.54e-04320536GO:0016323
GeneOntologyCellularComponentapical plasma membrane

ABCC1 SLC9A8 SLC34A1 ABCC5 SLC13A2 SLC23A1 SLC5A3

2.18e-04487537GO:0016324
GeneOntologyCellularComponenttransmembrane transporter complex

CLCN7 SCN4A SCN5A SCN10A KCNMB3 HCN2 SLC5A3

3.35e-04523537GO:1902495
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNMB3 HCN2 SLC5A3

1.60e-0391533GO:0008076
GeneOntologyCellularComponentpotassium channel complex

KCNMB3 HCN2 SLC5A3

2.34e-03104533GO:0034705
GeneOntologyCellularComponentcluster of actin-based cell projections

MYO3A SLC34A1 ACE SLC23A1

2.45e-03223534GO:0098862
HumanPhenoHypokalemia

SLC34A1 SCN4A SCN5A SCN10A SLC4A4

2.66e-0579245HP:0002900
DomainNa_channel_asu

SCN4A SCN5A SCN10A

2.55e-0610533IPR001696
DomainNa_trans_assoc

SCN4A SCN5A SCN10A

2.55e-0610533IPR010526
DomainNa_trans_assoc

SCN4A SCN5A SCN10A

2.55e-0610533PF06512
DomainRabGDI

GDI1 GDI2

7.90e-062532IPR000806
DomainTMEM126

TMEM126A TMEM126B

7.90e-062532PF07114
DomainTMEM126

TMEM126A TMEM126B

7.90e-062532IPR009801
DomainABC_TRANSPORTER_2

ABCC1 ABCB7 ABCA13 ABCC5

1.02e-0548534PS50893
DomainABC_tran

ABCC1 ABCB7 ABCA13 ABCC5

1.02e-0548534PF00005
DomainABC_TRANSPORTER_1

ABCC1 ABCB7 ABCA13 ABCC5

1.11e-0549534PS00211
DomainABC_transporter-like

ABCC1 ABCB7 ABCA13 ABCC5

1.21e-0550534IPR003439
DomainABC_membrane

ABCC1 ABCB7 ABCC5

4.19e-0524533PF00664
DomainGDP_dissociation_inhibitor

GDI1 GDI2

4.72e-054532IPR018203
DomainGDI

GDI1 GDI2

4.72e-054532PF00996
DomainABC_TM1F

ABCC1 ABCB7 ABCC5

6.72e-0528533PS50929
DomainABC1_TM_dom

ABCC1 ABCB7 ABCC5

6.72e-0528533IPR011527
DomainIQ_motif_EF-hand-BS

MYO3A SCN4A SCN5A SCN10A

1.23e-0490534IPR000048
DomainIQ

MYO3A SCN4A SCN5A SCN10A

1.40e-0493534PS50096
DomainABC_transporter_CS

ABCC1 ABCB7 ABCC5

2.29e-0442533IPR017871
DomainIon_trans_dom

SCN4A SCN5A SCN10A HCN2

3.06e-04114534IPR005821
DomainIon_trans

SCN4A SCN5A SCN10A HCN2

3.06e-04114534PF00520
DomainChannel_four-helix_dom

SCN4A SCN5A SCN10A

5.67e-0457533IPR027359
Domain-

SCN4A SCN5A SCN10A

5.67e-04575331.20.120.350
DomainAAA+_ATPase

ABCC1 ABCB7 ABCA13 ABCC5

7.40e-04144534IPR003593
DomainAAA

ABCC1 ABCB7 ABCA13 ABCC5

7.40e-04144534SM00382
DomainIQ

MYO3A SCN4A SCN10A

1.08e-0371533PF00612
DomainIQ

MYO3A SCN4A SCN5A

1.57e-0381533SM00015
DomainBeta_defensin

DEFB107A DEFB127

1.76e-0322532IPR025933
DomainDefensin_beta_2

DEFB107A DEFB127

1.76e-0322532PF13841
PathwayKEGG_ABC_TRANSPORTERS

ABCC1 ABCB7 ABCA13 ABCC5

1.02e-0544444M11911
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ABCC1 SLC9A8 ABCB7 CLCN7 SLC34A1 ABCC5 ATP10B SLC4A4 SLC13A2 LETM1 SLC5A3

1.15e-057364411M27287
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

ABCC1 SLC9A8 ABCB7 CLCN7 SLC34A1 ABCC5 ATP10B SLC4A4 SLC13A2 SLC5A3

3.61e-056814410MM14985
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN4A SCN5A SCN10A

1.20e-0431443M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN4A SCN5A SCN10A

1.32e-0432443M27455
PathwayREACTOME_L1CAM_INTERACTIONS

RPS6KA1 SCN4A SCN5A SCN10A

5.38e-04121444M872
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN4A SCN5A SCN10A

2.95e-07954316382098
Pubmed

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

SCN5A SCN10A

2.37e-06254224642470
Pubmed

Modulation of dendritic cell trafficking to and from the airways.

ABCC1 CCR8

2.37e-06254216517726
Pubmed

Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat.

SCN5A SCN10A

2.37e-06254215047701
Pubmed

Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells.

ABCC1 ABCC5

2.37e-06254212646196
Pubmed

Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

SCN4A SCN5A

2.37e-06254230944319
Pubmed

Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants.

SCN5A SCN10A

2.37e-06254231292628
Pubmed

Effect of NBCe1 deletion on renal citrate and 2-oxoglutarate handling.

SLC4A4 SLC13A2

2.37e-06254227117802
Pubmed

Opioid-Induced Hyperalgesia and Tolerance Are Driven by HCN Ion Channels.

SCN10A HCN2

2.37e-06254238124021
Pubmed

Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.

SCN4A SCN5A

2.37e-06254211834499
Pubmed

Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome.

SCN5A SCN10A

2.37e-06254224998131
Pubmed

Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.

GDI1 GDI2

2.37e-0625427585614
Pubmed

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

SCN5A SCN10A

2.37e-06254224360055
Pubmed

Single nucleotide polymorphisms of SCN5A and SCN10A genes increase the risk of ventricular arrhythmias during myocardial infarction.

SCN5A SCN10A

2.37e-06254232330377
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CLCN7 SCN4A SCN5A SCN10A HCN2

2.56e-0613954516985003
Pubmed

Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.

ABCC1 ABCB7 ABCC5

6.13e-062354310708515
Pubmed

Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

ABCC1 ABCC5

7.09e-06354216156793
Pubmed

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

GDI1 GDI2

7.09e-06354226240314
Pubmed

Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.

GDI1 GDI2

7.09e-0635427543319
Pubmed

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.

SCN4A SCN5A

7.09e-06354220038812
Pubmed

Time and concentration dependency of P-gp, MRP1 and MRP5 induction in response to gemcitabine uptake in Capan-2 pancreatic cancer cells.

ABCC1 ABCC5

7.09e-06354225564970
Pubmed

HCN2 ion channels play a central role in inflammatory and neuropathic pain.

SCN10A HCN2

7.09e-06354221903816
Pubmed

Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.

GDI1 GDI2

7.09e-0635427513052
Pubmed

Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.

SCN4A SCN5A

7.09e-06354215746172
Pubmed

The multidrug resistance protein family.

ABCC1 ABCC5

7.09e-06354210581366
Pubmed

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.

ABCC1 ABCC5

7.09e-06354210581368
Pubmed

A family of drug transporters: the multidrug resistance-associated proteins.

ABCC1 ABCC5

7.09e-06354210944550
Pubmed

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.

SCN5A SCN10A

7.09e-06354225998140
Pubmed

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.

SCN10A HCN2

1.42e-05454228767511
Pubmed

Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.

ABCC1 ABCC5

1.42e-05454218690847
Pubmed

Genome-wide association studies of the PR interval in African Americans.

SCN5A SCN10A

1.42e-05454221347284
Pubmed

cGMP transport by vesicles from human and mouse erythrocytes.

ABCC1 ABCC5

1.42e-05454217229149
Pubmed

Allele and genotype frequencies of polymorphic DCP1, CETP, ADRB2, and HTR2A in the Egyptian population.

HTR2A ACE

1.42e-05454211956670
Pubmed

Human skeletal muscle drug transporters determine local exposure and toxicity of statins.

ABCC1 ABCC5

1.42e-05454219940267
Pubmed

Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood-brain barrier.

ABCC1 ABCC5

1.42e-05454216361063
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCC1 ABCC5 SLC4A4 SLC5A3

2.21e-0510554430280653
Pubmed

Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction.

ABCC1 ABCC5

2.36e-05554212388627
Pubmed

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

SCN5A SCN10A

2.36e-05554222706305
Pubmed

Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.

SCN5A SCN10A

2.36e-05554223463857
Pubmed

GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.

GDI1 GDI2

2.36e-05554219570034
Pubmed

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

SCN5A SCN10A

2.36e-05554223872634
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN4A SCN5A

2.36e-05554217724025
Pubmed

Functional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic cardiomyopathy: AT1R as a potential modifier.

HTR2A ACE

2.36e-05554220594303
Pubmed

Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.

GDI1 GDI2

2.36e-05554211929610
Pubmed

Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.

ABCC1 ABCC5

2.36e-05554222272278
Pubmed

The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.

GDI1 GDI2

3.54e-05654211809807
Pubmed

Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.

SCN5A SCN10A

4.94e-05754223139255
Pubmed

Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.

ABCC1 ABCC5

4.94e-05754220922799
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

STS ZNF789 TRO SCN4A TM9SF3 CAPRIN2 ABCC5 ATP10B LETM1 SFT2D2

6.58e-051442541035575683
Pubmed

Interaction between genetic polymorphisms and stressful life events in first episode depression.

HTR2A ACE

6.59e-05854219339052
Pubmed

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

ABCC1 ABCC5

6.59e-05854215802388
Pubmed

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment.

HTR2A ACE

6.59e-05854220022223
Pubmed

Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.

SCN4A SCN5A

6.59e-0585429412493
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

ABCC1 ABCC5 SLC5A3

7.41e-055254326590417
Pubmed

Familial pure proximal renal tubular acidosis--a clinical and genetic study.

SLC9A8 SLC4A4

8.46e-05954217881426
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN4A SCN5A

8.46e-05954215746173
Pubmed

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

SCN5A SCN10A SLC4A4

9.76e-055754324952745
Pubmed

Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.

ABCC1 ABCC5

1.29e-041154218619525
Pubmed

Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.

HSD11B1 ACE

1.29e-041154220486282
Pubmed

A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.

TMEM126A TMEM126B

1.29e-041154219570815
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

RIF1 TRO CAPRIN2 SCN10A

1.38e-0416854430631154
Pubmed

Genome-wide association study of PR interval.

SCN5A SCN10A

1.55e-041254220062060
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN5A SCN10A

1.83e-041354215123669
Pubmed

Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

SLC10A3 GDI1

2.13e-04145428733135
Pubmed

Several common variants modulate heart rate, PR interval and QRS duration.

SCN5A SCN10A

2.13e-041454220062063
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

SCN5A HCN2

2.13e-041454229107716
Pubmed

LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line.

ABCC1 ABCC5

2.45e-041554228112518
Pubmed

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

SCN5A SCN10A

2.80e-041654225035420
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

IFNGR1 CLCN7 RPS6KA1 ABCC5 SLC43A3

2.98e-0437754538117590
Pubmed

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.

SCN5A SCN10A

3.17e-041754221076409
Pubmed

Genetic determinants of P wave duration and PR segment.

SCN5A SCN10A

3.17e-041754224850809
Pubmed

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.

ABCC1 ABCC5

3.56e-041854231791063
Pubmed

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.

SCN5A SCN10A

3.56e-041854231666509
Pubmed

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.

ABCB7 ABCC5

5.36e-04225428894702
Pubmed

Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.

SCN4A SCN5A

5.86e-042354216637659
Pubmed

Brugada Syndrome

SCN5A SCN10A

6.39e-042454220301690
Pubmed

Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.

ABCC1 HTR2A ACE

6.44e-0410854319956635
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

IFNGR1 ABCC1 ABCB7 TM9SF3 ABCC5 SLC4A4 GDI2

6.51e-0495254738569033
Pubmed

Endosomal Rab cycles regulate Parkin-mediated mitophagy.

GDI1 GDI2

8.72e-042854229360040
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

SCN10A SLC4A4 SLC13A2 ACE GDI2 SLC23A1 SFT2D2

9.52e-04101654719056867
Pubmed

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

HSD11B1 ACE SLC23A1

9.83e-0412554319019335
Pubmed

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.

SCN5A SCN10A

1.00e-033054239366945
Pubmed

Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.

HSD11B1 ACE SLC23A1

1.05e-0312854318818748
Pubmed

Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.

HSD11B1 ACE SLC23A1

1.05e-0312854319527514
Pubmed

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.

SCN5A HCN2

1.07e-033154217473172
Pubmed

Discovery of five conserved beta -defensin gene clusters using a computational search strategy.

DEFB107A DEFB127

1.52e-033754211854508
Cytoband17q23.3

SCN4A ACE

5.78e-043054217q23.3
Cytoband10q23.31

ANKRD22 LIPM

7.44e-043454210q23.31
Cytoband11q14.1

TMEM126A TMEM126B

1.13e-034254211q14.1
CytobandEnsembl 112 genes in cytogenetic band chr3p22

SCN5A SCN10A CCR8

1.35e-03184543chr3p22
GeneFamilySodium voltage-gated channel alpha subunits

SCN4A SCN5A SCN10A

1.04e-0694331203
GeneFamilySolute carriers

SLC9A8 SLC34A1 SLC10A3 SLC43A3 SLC4A4 SLC13A2 SLC23A1 SLC5A3

3.59e-06395438752
GeneFamilyATP binding cassette subfamily C

ABCC1 ABCC5

4.24e-0413432807
GeneFamilyDefensins, beta

DEFB107A DEFB127

5.58e-0347432503
GeneFamilyShort chain dehydrogenase/reductase superfamily

DHRS3 HSD11B1

1.41e-0276432743
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

IFNGR1 RIF1 DHRS3 ATP10B SLC4A4

4.27e-06199545262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
Drugverapamil

ABCC1 MYO3A ABCB7 HTR2A ABCA13 SCN4A SCN5A SCN10A ABCC5 KCNMB3 ACE

1.38e-084905311CID000002520
DrugAC1L8Y60

SLC9A8 CLCN7 SLC34A1 HSD11B1 SLC4A4 ACE

5.96e-0889536CID000410009
Drugsodium

ACTL7A SLC9A8 SLC34A1 SCN4A SCN5A SCN10A SLC10A3 KCNMB3 SLC43A3 SLC4A4 HCN2 SLC13A2 SLC23A1

1.78e-079445313CID000000923
Drugbumetanide

ACTL7A SLC9A8 CLCN7 SLC34A1 SLC10A3 SLC4A4 SLC13A2

5.35e-07209537CID000002471
Drugquindine

ABCC1 SCN4A SCN5A SCN10A KCNMB3 HCN2 LETM1

7.33e-07219537CID000001065
Drugcyclaine

STS SCN5A SCN10A

9.91e-079533CID000010770
Drugfurosemide

CLCN7 SLC34A1 SLC10A3 HSD11B1 SLC4A4 SLC13A2 ACE

3.10e-06272537CID000003440
Drugcarbamazepine

ABCB7 SCN4A SCN5A SCN10A SLC43A3 SLC13A2

3.67e-06179536CID000002554
Drug1-undecanol

HTR2A STS HSD11B1

4.26e-0614533CID000008184
DrugHexylcaine

SCN5A SCN10A

5.32e-062532DB00473
DrugFlecainide

SCN4A SCN5A

5.32e-062532DB01195
DrugDipyrone [5907-38-0]; Up 200; 12uM; MCF7; HT_HG-U133A

RIF1 STS CLCN7 ATP10B SLC43A3 MOCS1

6.94e-062005366030_UP
DrugCocaine

HTR2A CLCN7 ICE2 RPS6KA1 SCN10A ABCC5 SLC4A4 SSTR2 HCN2 ACE SLC23A1 SFT2D2 SLC5A3

7.16e-0613145313ctd:D003042
Drugtriamterene

SLC9A8 SCN4A SCN10A ACE

1.01e-0558534CID000005546
DrugDibucaine

SCN5A SCN10A

1.59e-053532DB00527
DrugGBR 12909

HTR2A TRO SCN4A SCN10A

2.02e-0569534CID000003455
Drugglibenclamide

ABCC1 ABCB7 CLCN7 ABCA13 ABCC5 KCNMB3 ACE

2.81e-05382537CID000003488
DrugLidocaine

SCN5A SCN10A

3.18e-054532DB00281
DrugAC1L7GDJ

ABCC1 ABCC5

3.18e-054532CID000310029
Druggrepafloxacin glucuronide

ABCC1 ABCC5

3.18e-054532CID000443296
DrugAC1Q5QTP

ABCC1 ABCC5 ACE

3.35e-0527533CID000071324
DrugAC1L1MOZ

SCN4A SCN5A SCN10A

3.35e-0527533CID000031958
DrugAC1L38YU

ABCC1 ABCC5 SSTR2 SLC13A2

3.45e-0579534CID000085196
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; HL60; HT_HG-U133A

ABCC1 SLC9A8 CLCN7 TM9SF3 SLC5A3

3.52e-051605356133_DN
DrugNaCl

ACTL7A SLC9A8 STS LIPM SLC10A3 HSD11B1 SLC4A4 ACE

4.48e-05564538CID000005234
Drugtocainide

SCN4A SCN5A SCN10A

4.63e-0530533CID000038945
Drugoxcarbazepine

SCN4A SCN5A SLC43A3

4.63e-0530533CID000034312
DrugNSC671054

ABCC1 ABCC5

5.29e-055532CID005357223
Drugmonochlorobimane

ABCC1 ABCC5 SLC4A4

6.77e-0534533CID000114886
DrugAC1LAHTK

ABCC1 ABCC5

7.93e-056532CID000468713
DrugAPETx1, Anthopleura elegantissima

SCN4A SCN10A

7.93e-056532ctd:C475726
DrugAC1NB6SN

ABCC1 ABCC5

7.93e-056532CID004488324
Drug3-isoreserpine

ABCC1 ABCB7 HTR2A ABCA13 ABCC5

7.96e-05190535CID000005052
DrugChlorprothixene hydrochloride [6469-93-8]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ABCC1 STS RPS6KA1 POLR1B SLC4A4

8.57e-051935355291_DN
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; HL60; HT_HG-U133A

RIF1 TRO SCN5A ATP10B IMPG2

9.00e-051955352553_UP
DrugPapaverine hydrochloride [61-25-6]; Up 200; 10.6uM; PC3; HT_HG-U133A

RIF1 HTR2A STS CLCN7 TRO

9.22e-051965355769_UP
DrugCitalopram hydrobromide [59729-32-7]; Up 200; 1uM; MCF7; HT_HG-U133A

HTR2A SCN10A SLC4A4 MMP20 SLC13A2

9.22e-051965353903_UP
DrugProgesterone [57-83-0]; Up 200; 12.8uM; PC3; HT_HG-U133A

ABCC1 TRO SCN10A ATP10B IMPG2

9.22e-051965356646_UP
DrugGelsemine [509-15-9]; Up 200; 12.4uM; MCF7; HT_HG-U133A

CLCN7 ATP10B CCR8 SLC4A4 SLC13A2

9.44e-051975352817_UP
Drugpotassium

CLCN7 SCN4A SCN5A SCN10A SLC10A3 KCNMB3 SLC4A4 SSTR2 HCN2 ACE

9.52e-0510085310CID000000813
DrugBoldine [476-70-0]; Down 200; 12.2uM; PC3; HT_HG-U133A

STS CLCN7 SLC4A4 MOCS1 SFT2D2

9.67e-051985354004_DN
Drugwortmannin from Penicillium funiculosum; Up 200; 0.01uM; HL60; HT_HG-U133A

RIF1 STS DHRS3 SCN10A SLC4A4

9.67e-051985356202_UP
DrugRapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A

RIF1 SCN5A SCN10A SLC4A4 MOCS1

9.67e-051985356201_UP
Drugsulfobromophthalein

ABCC1 ABCB7 ABCC5 SLC4A4

9.75e-05103534CID000005345
Drug(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; MCF7; HT_HG-U133A

SLC9A8 CLCN7 MOCS1 IMPG2 SLC5A3

9.90e-051995356794_UP
DrugProbenecid [57-66-9]; Up 200; 14uM; HL60; HT_HG-U133A

MYO3A CLCN7 SCN5A SCN10A SLC13A2

9.90e-051995352464_UP
Drugthiazide

SLC34A1 SCN4A SLC4A4 ACE

1.01e-04104534CID000002720
Drugchloride

ACTL7A SLC9A8 HTR2A CLCN7 SLC34A1 SCN4A SLC4A4 HCN2 SLC13A2 ACE

1.13e-0410295310CID000000312
Drug4,4'-diisothiocyanostilbene-2,2'-disulfonic acid

CLCN7 SLC34A1 SLC4A4 SLC13A2 SLC23A1

1.16e-04206535CID000040600
Drugisoproterenol

ACTL7A MYO3A CLCN7 SCN4A SCN5A SCN10A HCN2 ACE

1.47e-04669538CID000003779
Drugalpha-fluoro-beta-ureidopropionic acid

RIF1 STS

1.48e-048532CID000151244
DrugCocaine

SCN5A SCN10A

1.48e-048532DB00907
Drug1,3-dibromopropane

RIF1 LIPM

1.48e-048532CID000008001
Druglamotrigine

SCN4A SCN5A SCN10A SLC43A3

1.54e-04116534CID000003878
Drugpilsicainide

SCN4A SCN5A SCN10A

1.68e-0446533CID000004820
Drug17alpha-estradiol

ABCC1 HTR2A STS CLCN7 ICE2 ABCC5 CCR8 KCNMB3 SSTR2 MMP20 ACE

1.70e-0413035311CID000000450
Drug2qc6

POLR1B SLC4A4

1.89e-049532CID005795340
Drug4'-methoxy-1-naphthylfenoterol

ABCC1 ABCC5

1.89e-049532ctd:C000603500
DrugMexiletine

SCN5A SCN10A

1.89e-049532ctd:D008801
Drugsodium antimony

IFNGR1 ABCC1

2.36e-0410532CID000025469
Drugoxepin

HTR2A STS

2.36e-0410532CID006451477
DrugBenzimidazoles

HTR2A STS

2.36e-0410532ctd:D001562
DrugAC1L3C7Z

ABCC1 ACE

2.36e-0410532CID000086747
Druglosartan

ACTL7A SLC9A8 HSD11B1 SLC4A4 MMP20 ACE

2.39e-04378536CID000003961
Drugamyl nitrite

SLC9A8 HSD11B1 ACE

2.57e-0453533CID000008053
DrugMethoxychlor

ABCC1 STS SCN4A HSD11B1 SSTR2 SLC13A2 ACE

2.69e-04549537ctd:D008731
Drugp-aminohippurate

TM9SF3 ACE SLC23A1

2.87e-0455533CID000002148
Drug2,4,5-trichlorophenol

ABCC5 ACE SLC23A1

3.03e-0456533CID000007271
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN4A SCN5A SCN10A

6.51e-0710533DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN4A SCN5A SCN10A

6.51e-0710533DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN4A SCN5A SCN10A

1.19e-0612533DOID:0060170 (implicated_via_orthology)
DiseaseBrugada ECG Pattern

SCN5A SCN10A

1.89e-054532C1721096
DiseaseSudden death

SCN10A ACE

3.15e-055532C0011071
Diseaseelectrocardiography, PR interval

SCN5A SCN10A

6.61e-057532EFO_0004327, EFO_0004462
Diseasesupraventricular ectopy

SCN5A SCN10A

1.13e-049532EFO_0009277
Diseaseepilepsy (implicated_via_orthology)

SCN4A SCN5A SCN10A SLC13A2

2.13e-04163534DOID:1826 (implicated_via_orthology)
DiseaseBrugada Syndrome 1

SCN5A SCN10A

2.44e-0413532C4551804
Diseaseuveitis (is_marker_for)

IFNGR1 ACE

2.44e-0413532DOID:13141 (is_marker_for)
DiseaseT wave morphology measurement

SCN5A SCN10A

2.84e-0414532EFO_0008398
Diseaseinsulin metabolic clearance rate measurement, glucose homeostasis measurement

RPS6KA1 SLC43A3

2.84e-0414532EFO_0006830, EFO_0006896
DiseaseP wave duration

SCN5A SCN10A

3.27e-0415532EFO_0005094
DiseaseRomano-Ward Syndrome

SCN5A SCN10A

3.74e-0416532C0035828
Diseasevitamin C measurement

SLC34A1 SLC23A1

3.74e-0416532EFO_0600003
Diseaseorofacial cleft, sex interaction measurement

HTR2A SCN10A OR5A2

5.04e-0486533EFO_0008343, MONDO_0000358
Diseaseosteoporosis (implicated_via_orthology)

IFNGR1 ACE

5.31e-0419532DOID:11476 (implicated_via_orthology)
DiseaseBrugada syndrome

SCN5A SCN10A

5.31e-0419532MONDO_0015263
DiseaseBrugada Syndrome (disorder)

SCN5A SCN10A

8.52e-0424532C1142166
Diseasepre-eclampsia (is_implicated_in)

HSD11B1 ACE

9.25e-0425532DOID:10591 (is_implicated_in)
DiseaseStreptozotocin Diabetes

STS HSD11B1 ACE

9.78e-04108533C0038433
DiseaseDiabetes Mellitus, Experimental

STS HSD11B1 ACE

9.78e-04108533C0011853
DiseaseAlloxan Diabetes

STS HSD11B1 ACE

9.78e-04108533C0002152
Diseaseblood rubidium measurement

RIF1 ABCA13

1.00e-0326532EFO_0021529
Diseasecardiovascular age measurement

SCN5A SCN10A

1.25e-0329532EFO_0803380
Diseasehypertension (is_implicated_in)

HTR2A HSD11B1 ACE

1.36e-03121533DOID:10763 (is_implicated_in)
Diseaseheart function measurement

SCN5A SCN10A

1.71e-0334532EFO_0004311
DiseaseIGA Glomerulonephritis

SLC43A3 ACE

1.71e-0334532C0017661

Protein segments in the cluster

PeptideGeneStartEntry
FLMKMALDKIAFIPF

ACE

1051

P12821
LAIADMLLGFLVMPV

HTR2A

116

P28223
LLPVLFVALAMGLFM

ABCA13

4231

Q86UQ4
LMPVLLIGYFLMVSK

ANKRD22

96

Q5VYY1
MAFMKKYLLPILGLF

HSD11B1

1

P28845
PLAIVLFVIMIKDGM

ATP10B

121

O94823
LIPKFLMANGQLVKM

GDI2

76

P50395
TKFLLLPDMMIKGLF

LIPM

226

Q5VYY2
MPGAMKIFVFILAAL

DEFB107A

1

Q8IZN7
MEFLLPVAVKLFPNM

LETM1

221

O95202
FPIMLVLMTAKIVGD

CLCN7

581

P51798
HPQMKIFLFMLFLGL

OR5A2

21

Q8NGI9
MLLGLLGQFLVMPLY

SLC10A3

226

P09131
AFLMAKVFMLPKALA

SLC10A3

241

P09131
MGLFMIIAILLFQKP

DEFB127

1

Q9H1M4
KNRPMILIELFLMFP

MOCS1

376

Q9NZB8
QAGAMLLKVPLMLTF

SLC34A1

96

Q06495
PLAFLVIMALFMLNV

ABCC5

856

O15440
LMGFFPFRVEMGLKL

ICE2

201

Q659A1
MKLAFLFLGPMALLL

GPHB5

1

Q86YW7
KMNILGLLIPFTIFM

CCR8

201

P51685
MLKLAVNVPLYVNLM

CAPRIN2

1051

Q6IMN6
LMFFLLGTTILKPFM

KCNMB3

71

Q9NPA1
LIPKFLMANGQLVKM

GDI1

76

P31150
LFPLILFPMMGIVDA

SLC13A2

61

Q13183
FTMLLFMVGNLIIIP

HCN2

216

Q9UL51
NVMLMPTGIIKLIDF

MAP3K19

1191

Q56UN5
LGALVMFPLQMIYLV

DHRS3

6

O75911
MALLFLLPLVMQGVS

IFNGR1

1

P15260
MKVLPASGLAVFLIM

MMP20

1

O60882
DLMMFSGPQILKLLI

ABCC1

336

P33527
KGIRTLLFALMMSLP

SCN4A

1466

P35499
MMSLPALFNIGLLLF

SCN4A

1476

P35499
IFLMGPVKQLKRMFE

SFT2D2

81

O95562
FRKMLFPILLQTMFS

TMEM126A

156

Q9H061
LMAIPLVFQIMFGIL

TMEM126B

196

Q8IUX1
KFLLLLPGLETVEMM

RIF1

961

Q5UIP0
KGIRTLLFALMMSLP

SCN5A

1641

Q14524
MMSLPALFNIGLLLF

SCN5A

1651

Q14524
MPLRKMKIPFLLLFF

STS

1

P08842
LRKTPSLEFGMMIIF

SLC9A8

291

Q9Y2E8
MAGFLKLLPMFIIVV

SLC5A3

301

P53794
LFLAMPMLTIGGILF

SLC43A3

126

Q8NBI5
MIMFPLFGKISLGIL

IMPG2

1

Q9BZV3
LFMLGLPFLAMQVAL

SSTR2

91

P30874
ALVFNLLPIMFEVML

ABCB7

266

O75027
MFFKPSLIKSMQLGL

ACTL7A

321

Q9Y615
LLRIQIFKMFPIMLA

SLC23A1

246

Q9UHI7
PKLGLLMVILSVIFM

TRO

531

Q12816
KGIRTLLFALMMSLP

SCN10A

1591

Q9Y5Y9
MMSLPALFNIGLLLF

SCN10A

1601

Q9Y5Y9
IKQMFIGAFLIPAMV

TM9SF3

356

Q9HD45
FPVMILALVAVRKGM

SLC4A4

976

Q9Y6R1
LMRIFTMGIDLTKPF

POLR1B

416

Q9H9Y6
NMVLLGFQFPKPEMI

ZNF789

46

Q5FWF6
ALPLSMTFIGMKFLE

TMEM272

31

A0A1B0GTI8
MTLILKAKLGMPQFL

RPS6KA1

271

Q15418
LDMFLQKPMGLLSLL

MYO3A

776

Q8NEV4