Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	transcription elongation factor complex	PEX2 SNW1 ERCC6	1.55e-04	56	39	3	GO:0008023
Domain	CUB	BMP1 PCOLCE2 OVCH2 CSMD3 TLL1	4.12e-08	49	37	5	PF00431
Domain	CUB	BMP1 PCOLCE2 OVCH2 CSMD3 TLL1	4.58e-08	50	37	5	SM00042
Domain	CUB	BMP1 PCOLCE2 OVCH2 CSMD3 TLL1	6.17e-08	53	37	5	PS01180
Domain	CUB_dom	BMP1 PCOLCE2 OVCH2 CSMD3 TLL1	8.95e-08	57	37	5	IPR000859
Domain	-	BMP1 PCOLCE2 CSMD3 TLL1	3.30e-06	52	37	4	2.60.120.290
Domain	BMP_1/tolloid-like	BMP1 TLL1	1.14e-05	3	37	2	IPR015446
Domain	Peptidase_M12A	BMP1 TLL1	5.70e-05	6	37	2	IPR001506
Domain	Astacin	BMP1 TLL1	5.70e-05	6	37	2	PF01400
Domain	MetalloPept_cat_dom	BMP1 ADAM18 TLL1	5.49e-04	81	37	3	IPR024079
Domain	-	BMP1 ADAM18 TLL1	5.49e-04	81	37	3	3.40.390.10
Domain	ZnMc	BMP1 TLL1	1.50e-03	29	37	2	SM00235
Domain	Peptidase_Metallo	BMP1 TLL1	1.50e-03	29	37	2	IPR006026
Domain	SH3	FGR TJP1 SRGAP1	8.87e-03	216	37	3	PS50002
Domain	SH3	FGR TJP1 SRGAP1	8.87e-03	216	37	3	SM00326
Domain	SH3_domain	FGR TJP1 SRGAP1	9.33e-03	220	37	3	IPR001452
Domain	EGF_3	BMP1 ADAM18 TLL1	1.12e-02	235	37	3	PS50026
Domain	PROTEIN_KINASE_ATP	PKDCC FGR NEK5 BUB1	1.25e-02	459	37	4	PS00107
Domain	EGF_CA	BMP1 TLL1	1.26e-02	86	37	2	PF07645
Domain	EGF-like_dom	BMP1 ADAM18 TLL1	1.30e-02	249	37	3	IPR000742
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	BMP1 PCOLCE2 TLL1	2.34e-04	61	28	3	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	BMP1 PCOLCE2 TLL1	3.09e-04	67	28	3	M26999
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	BMP1 TLL1	3.93e-04	15	28	2	M27161
Pathway	REACTOME_COLLAGEN_FORMATION	BMP1 PCOLCE2 TLL1	4.48e-04	76	28	3	MM14573
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	BMP1 TLL1	5.71e-04	18	28	2	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	BMP1 TLL1	5.71e-04	18	28	2	MM14882
Pathway	REACTOME_COLLAGEN_FORMATION	BMP1 PCOLCE2 TLL1	7.34e-04	90	28	3	M631
Pubmed	PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.	BMP1 PCOLCE2 TLL1	1.30e-08	5	39	3	12393877
Pubmed	Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis.	BMP1 TLL1	1.23e-06	2	39	2	33169406
Pubmed	Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1.	BMP1 TLL1	1.23e-06	2	39	2	8661043
Pubmed	Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.	BMP1 TLL1	1.23e-06	2	39	2	7798260
Pubmed	Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.	BMP1 TLL1	1.23e-06	2	39	2	28000152
Pubmed	Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.	BMP1 TLL1	1.23e-06	2	39	2	20658214
Pubmed	Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation.	BMP1 TLL1	3.67e-06	3	39	2	27847137
Pubmed	Bone morphogenetic protein-1 processes probiglycan.	BMP1 TLL1	3.67e-06	3	39	2	10896944
Pubmed	Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase.	BMP1 TLL1	3.67e-06	3	39	2	20043912
Pubmed	Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.	BMP1 TLL1	3.67e-06	3	39	2	16507574
Pubmed	Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.	BMP1 TLL1	3.67e-06	3	39	2	19079247
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL1	3.67e-06	3	39	2	18824173
Pubmed	Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.	BMP1 TLL1	3.67e-06	3	39	2	24419319
Pubmed	Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.	BMP1 TLL1	3.67e-06	3	39	2	12808086
Pubmed	BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.	BMP1 TLL1	3.67e-06	3	39	2	28068493
Pubmed	Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.	BMP1 TLL1	3.67e-06	3	39	2	32209430
Pubmed	The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.	BMP1 TLL1	7.34e-06	4	39	2	10331975
Pubmed	BMP1-like proteinases are essential to the structure and wound healing of skin.	BMP1 TLL1	7.34e-06	4	39	2	27363389
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	BMP1 TLL1	1.22e-05	5	39	2	10479448
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	BMP1 EFCAB7 ADAR NEK5	2.56e-05	152	39	4	34299191
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	CSMD3 ELFN2 WDR59	4.94e-05	63	39	3	11572484
Pubmed	Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.	BMP1 TLL1	1.85e-04	18	39	2	19914233
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	SNW1 KIDINS220 TJP1 EIF4G2	1.93e-04	256	39	4	33397691
Pubmed	FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.	FGR TJP1	2.07e-04	19	39	2	23616926
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	SNW1 ADAR TJP1 EIF4G2	3.30e-04	295	39	4	26209609
Pubmed	Integrating genetic and network analysis to characterize genes related to mouse weight.	ATP6V1C2 KIDINS220	4.88e-04	29	39	2	16934000
Pubmed	Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.	PKDCC PRCP	6.72e-04	34	39	2	7490078
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	SNW1 ADAR TJP1	8.02e-04	162	39	3	31363146
Pubmed	Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.	KIDINS220 TJP1	8.84e-04	39	39	2	24095980
Pubmed	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".	BMP1 BPNT1 BUB1	9.53e-04	172	39	3	20628624
Cytoband	3q26.1	WDR49 NMD3	2.62e-04	28	39	2	3q26.1
Cytoband	6p12.1	ZNF451 KLHL31	3.65e-04	33	39	2	6p12.1
Cytoband	1q41	BPNT1 DISP1	1.46e-03	66	39	2	1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr1q41	BPNT1 DISP1	2.86e-03	93	39	2	chr1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr2p25	ATP6V1C2 KIDINS220	5.26e-03	127	39	2	chr2p25
Cytoband	Ensembl 112 genes in cytogenetic band chr8p21	BMP1 EXTL3	5.92e-03	135	39	2	chr8p21
Cytoband	Ensembl 112 genes in cytogenetic band chr6p12	ZNF451 KLHL31	6.53e-03	142	39	2	chr6p12
Cytoband	Ensembl 112 genes in cytogenetic band chr3q26	WDR49 NMD3	1.46e-02	216	39	2	chr3q26
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL1	2.97e-05	6	26	2	894
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.71e-05	177	39	4	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.75e-05	178	39	4	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.79e-05	179	39	4	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.87e-05	181	39	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.87e-05	181	39	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.95e-05	183	39	4	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.95e-05	183	39	4	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	1.95e-05	183	39	4	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	2.03e-05	185	39	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	2.03e-05	185	39	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCOLCE2 TJP1 WDR49 SRGAP1	2.03e-05	185	39	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	ADAR PRCP B3GALNT2 EIF4G2	2.55e-05	196	39	4	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIDINS220 TJP1 PRCP DISP1	2.76e-05	200	39	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	KIDINS220 ADAR TJP1 DISP1	2.76e-05	200	39	4	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIDINS220 TJP1 PRCP DISP1	2.76e-05	200	39	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	KIDINS220 TJP1 PRCP DISP1	2.76e-05	200	39	4	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	KIDINS220 TJP1 PRCP EIF4G2	2.76e-05	200	39	4	041a34080120c9f613373c20dcc366292f558040
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	KIDINS220 TJP1 PRCP DISP1	2.76e-05	200	39	4	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIDINS220 ADAR TJP1 DISP1	2.76e-05	200	39	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
Disease	Malignant neoplasm of breast	BMP1 NRIP1 ERCC6 COG3 ADAR TLL1 B3GALNT2	3.28e-04	1074	37	7	C0006142
Disease	hormone measurement	PRCP KLHL31	5.00e-03	84	37	2	EFO_0004730
Disease	Dystonia	ERCC6 ADAR	5.23e-03	86	37	2	C0013421

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPVSSYPNTFEWQCK	BUB1	756	O43683
YPNTFEWQCKLPAIK	BUB1	761	O43683
PEPYDNNLNCVWKIT	CSMD3	1956	Q7Z407
WQKDQPYKVPLNSQI	ADAM18	161	Q9Y3Q7
NYWFVGTQKVPKPLC	GSG1	36	Q2KHT4
QWEEILKQPCPSQYS	BPNT1	91	O95861
YPPNKNCIWQLVAPT	BMP1	611	P13497
KKPQQQIYDNKSCWT	DISP1	671	Q96F81
EPNYQQELSKPQTWK	RAD21L1	401	Q9H4I0
CWFQPYQGKNPNTKH	ERCC6	776	P0DP91
ACWYQQKPGQSPVLV	IGLV3-1	51	P01715
NWPACQKAYNLNRTP	KIDINS220	1666	Q9ULH0
LECYVPSTNQWQPKT	KLHL31	436	Q9H511
EYNPCQGSKFPIKWT	FGR	411	P09769
QPPSKNQKIWYAVCT	PEX2	96	P28328
CQNKPYNNKTDIWSL	NEK5	176	Q6P3R8
SNKEIPWTLKYSQPC	CSNKA2IP	406	A0A1B0GTH6
LPAWPIKVVCQYLKN	PRCP	301	P42785
KWNSPPYVCSTQSEK	NRIP1	576	P48552
GVYPPNSKCTWKITV	PCOLCE2	51	Q9UKZ9
SPQTIYKWIKDNISP	EIF4G2	746	P78344
WISKPQEEKNFYLCP	ADAR	1211	P55265
PSQKTINKYWTPQTA	EFCAB7	71	A8K855
PKYTLSQQPWAQPAK	COG3	731	Q96JB2
LPYLNKVVVVWNSPK	EXTL3	686	O43909
PSCGVQVNKLWYKPV	B3GALNT2	196	Q8NCR0
SVYQCKEPKQIPWRA	GAPDHS	146	O14556
VCRWPSYKKKQPYAQ	RNF103	661	O00237
TIYTKPVWKSVNPQI	KIF28P	736	B7ZC32
VIVPKPNYSQWQKTY	ATP6V1C2	186	Q8NEY4
QYKKDQNLLSPVNCW	SRGAP1	86	Q7Z6B7
WSQVVPDPNKTTYVK	PKDCC	476	Q504Y2
KEYPPNKNCVWQVVA	TLL1	636	O43897
PSCGQSLVKVQPWNY	OVCH2	31	Q7RTZ1
YCPSEWRQVQKAPNL	TEX45	376	Q8NA69
TNWKPPLNCKIYNYL	ZNF451	921	Q9Y4E5
TAGINNKVCLWNPYV	WDR49	36	Q8IV35
NKVCLWNPYVVSKPV	WDR49	41	Q8IV35
KIPPCISNWKNAKGY	SNW1	246	Q13573
KYLNILPCQVPVWKA	WDR59	226	Q6PJI9
KTWQNKCLPGDPNYL	TJP1	1721	Q07157
KGYVWLAICSQNQPP	ELFN2	31	Q5R3F8
KQCQRYFQPPGTWIQ	NMD3	56	Q96D46