Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC6A4 GRIK1 APOB SIDT2 TMC7 TRPM7 ABCA12 RYR1 ITPR3 SIDT1	2.48e-06	1289	26	10	GO:0005215
GeneOntologyMolecularFunction	RNA transmembrane transporter activity	SIDT2 SIDT1	4.89e-06	3	26	2	GO:0051033
GeneOntologyMolecularFunction	nucleic acid transmembrane transporter activity	SIDT2 SIDT1	4.89e-06	3	26	2	GO:0051032
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIK1 RYR1 ITPR3	8.60e-06	31	26	3	GO:0099604
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A4 GRIK1 SIDT2 TMC7 TRPM7 ABCA12 RYR1 ITPR3 SIDT1	1.07e-05	1180	26	9	GO:0022857
GeneOntologyMolecularFunction	monoatomic ion channel activity	SLC6A4 GRIK1 TMC7 TRPM7 RYR1 ITPR3	2.22e-05	459	26	6	GO:0005216
GeneOntologyMolecularFunction	calcium channel activity	GRIK1 TRPM7 RYR1 ITPR3	2.23e-05	129	26	4	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	GRIK1 TRPM7 RYR1 ITPR3	4.13e-05	151	26	4	GO:0015085
GeneOntologyMolecularFunction	channel activity	SLC6A4 GRIK1 TMC7 TRPM7 RYR1 ITPR3	4.72e-05	525	26	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC6A4 GRIK1 TMC7 TRPM7 RYR1 ITPR3	4.77e-05	526	26	6	GO:0022803
GeneOntologyMolecularFunction	monoatomic cation channel activity	SLC6A4 GRIK1 TRPM7 RYR1 ITPR3	7.10e-05	343	26	5	GO:0005261
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 ITPR3	2.46e-04	18	26	2	GO:0015278
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A4 GRIK1 TRPM7 RYR1 ITPR3	2.94e-04	465	26	5	GO:0046873
GeneOntologyMolecularFunction	calcium ion binding	PRSS1 PCDHGC3 GLCE RYR1 CAPN2 ITPR3	3.30e-04	749	26	6	GO:0005509
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A4 GRIK1 TMC7 TRPM7 RYR1 ITPR3	4.48e-04	793	26	6	GO:0015075
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	GRIK1 RYR1 ITPR3	7.79e-04	140	26	3	GO:0099094
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 ITPR3	8.40e-04	33	26	2	GO:0005217
GeneOntologyMolecularFunction	gated channel activity	GRIK1 TMC7 RYR1 ITPR3	8.59e-04	334	26	4	GO:0022836
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	SIDT2 SIDT1	8.91e-04	34	26	2	GO:0022884
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A4 GRIK1 TRPM7 RYR1 ITPR3	1.14e-03	627	26	5	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A4 GRIK1 TRPM7 RYR1 ITPR3	1.47e-03	664	26	5	GO:0008324
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GRIK1 RYR1 ITPR3	1.96e-03	193	26	3	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	GRIK1 RYR1 ITPR3	2.08e-03	197	26	3	GO:0022834
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A4 GRIK1 TRPM7 RYR1 ITPR3	2.63e-03	758	26	5	GO:0015318
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SIDT2 SIDT1	2.67e-03	59	26	2	GO:0015932
GeneOntologyMolecularFunction	double-stranded RNA binding	SIDT2 SIDT1	4.61e-03	78	26	2	GO:0003725
GeneOntologyMolecularFunction	alcohol binding	ITPR3 SIDT1	7.75e-03	102	26	2	GO:0043178
GeneOntologyCellularComponent	smooth endoplasmic reticulum	APOB RYR1	1.49e-03	46	26	2	GO:0005790
GeneOntologyCellularComponent	neuronal cell body	GRIK1 APOB TRPM7 CAPN2 ITPR3	3.28e-03	835	26	5	GO:0043025
GeneOntologyCellularComponent	endoplasmic reticulum membrane	APOB LCLAT1 RYR1 ALG10 GET1 ITPR3	4.37e-03	1293	26	6	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	APOB LCLAT1 RYR1 ALG10 GET1 ITPR3	4.47e-03	1299	26	6	GO:0098827
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	SLC6A4 APOB SIRPB1 TRPM7 ABCA12 ITPR3	4.60e-03	1307	26	6	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	SLC6A4 APOB SIRPB1 TRPM7 ABCA12 ITPR3	4.92e-03	1325	26	6	GO:0012506
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	APOB LCLAT1 RYR1 ALG10 GET1 ITPR3	4.96e-03	1327	26	6	GO:0042175
GeneOntologyCellularComponent	cell body	GRIK1 APOB TRPM7 CAPN2 ITPR3	5.18e-03	929	26	5	GO:0044297
GeneOntologyCellularComponent	sarcoplasmic reticulum	RYR1 ITPR3	5.33e-03	88	26	2	GO:0016529
Domain	SID1_TM_fam	SIDT2 SIDT1	1.86e-06	2	26	2	IPR025958
Domain	SID-1_RNA_chan	SIDT2 SIDT1	1.86e-06	2	26	2	PF13965
Domain	RIH_assoc	RYR1 ITPR3	2.79e-05	6	26	2	PF08454
Domain	RIH_assoc-dom	RYR1 ITPR3	2.79e-05	6	26	2	IPR013662
Domain	RYDR_ITPR	RYR1 ITPR3	2.79e-05	6	26	2	PF01365
Domain	RIH_dom	RYR1 ITPR3	2.79e-05	6	26	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR3	2.79e-05	6	26	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR3	2.79e-05	6	26	2	IPR015925
Domain	Ins145_P3_rec	RYR1 ITPR3	2.79e-05	6	26	2	PF08709
Domain	-	RYR1 ITPR3	2.79e-05	6	26	2	1.25.10.30
Domain	MIR	RYR1 ITPR3	8.33e-05	10	26	2	PS50919
Domain	MIR	RYR1 ITPR3	8.33e-05	10	26	2	PF02815
Domain	MIR	RYR1 ITPR3	8.33e-05	10	26	2	SM00472
Domain	MIR_motif	RYR1 ITPR3	8.33e-05	10	26	2	IPR016093
Domain	Ion_trans_dom	TRPM7 RYR1 ITPR3	5.20e-04	114	26	3	IPR005821
Domain	Ion_trans	TRPM7 RYR1 ITPR3	5.20e-04	114	26	3	PF00520
Domain	EF-hand_8	RYR1 CAPN2	1.02e-03	34	26	2	PF13833
Pathway	WP_AIRWAY_SMOOTH_MUSCLE_CELL_CONTRACTION	RYR1 ITPR3	2.04e-04	16	19	2	M40060
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 ITPR3	2.90e-04	19	19	2	M47760
Pubmed	TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.	TRPM7 CAPN2	5.37e-07	2	26	2	16436382
Pubmed	A novel family of mammalian transmembrane proteins involved in cholesterol transport.	SIDT2 SIDT1	5.37e-07	2	26	2	28785058
Pubmed	Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.	RYR1 ITPR3	5.37e-07	2	26	2	21150295
Pubmed	Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1.	SIDT2 SIDT1	5.37e-07	2	26	2	26067272
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	TRPM7 RYR1 ITPR3	3.07e-06	38	26	3	30786075
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 ITPR3	3.22e-06	4	26	2	22100703
Pubmed	TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase.	TRPM7 CAPN2	3.22e-06	4	26	2	20070945
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR3	8.05e-06	6	26	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR3	8.05e-06	6	26	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR3	8.05e-06	6	26	2	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR3	8.05e-06	6	26	2	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR3	1.13e-05	7	26	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 CAPN2	1.13e-05	7	26	2	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 ITPR3	1.50e-05	8	26	2	19033399
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	ABCA12 RYR1 CAPN2 ITPR3	1.87e-05	214	26	4	22199357
Pubmed	Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.	SLC6A4 GRIK1	9.12e-05	19	26	2	19095219
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	SLC6A4 APOB	2.47e-04	31	26	2	20691427
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	FER1L6 GET1	4.99e-04	44	26	2	20200978
Cytoband	Ensembl 112 genes in cytogenetic band chr3q13	CD96 SIDT1	6.95e-03	221	26	2	chr3q13
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SIRPB1 LY75 CD96	6.57e-03	394	18	3	471
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RYR1 ITPR3	1.37e-02	181	18	2	694
Drug	strontium	TRPM7 RYR1 CAPN2 ITPR3	1.04e-06	68	26	4	CID000104798
Drug	mag-fura-2	TRPM7 RYR1 ITPR3	1.00e-05	37	26	3	CID000123839
Drug	AC1Q7BER	RYR1 ITPR3	1.88e-05	6	26	2	CID000005702
Drug	AC1L1DXE	SLC6A4 PRSS1 GRIK1 RYR1 ITPR3	1.98e-05	299	26	5	CID000002548
Drug	Br2BAPTA	RYR1 ITPR3	2.62e-05	7	26	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 ITPR3	2.62e-05	7	26	2	CID009547999
Drug	NSC7524	GRIK1 MSTN RYR1 ITPR3	5.15e-05	182	26	4	CID000005657
Drug	Ferrichrome A	FRRS1 SIDT1	5.61e-05	10	26	2	CID006449886
Drug	R 478	RYR1 ITPR3	6.85e-05	11	26	2	CID000084223
Drug	8-amino-cADPR	RYR1 ITPR3	6.85e-05	11	26	2	CID003081323
Drug	LMWH	PRSS1 APOB MSTN GLCE RYR1 ITPR3	8.34e-05	663	26	6	CID000000772
Drug	Fura-2AM	TRPM7 RYR1 ITPR3	9.87e-05	79	26	3	CID000105091
Drug	XeC compound	GRIK1 RYR1 ITPR3	1.18e-04	84	26	3	CID000005701
Drug	Gvapspat amide	RYR1 ITPR3	1.30e-04	15	26	2	CID000125015
Drug	borate	TRPM7 RYR1 ITPR3	1.87e-04	98	26	3	CID000007628
Drug	nitrendipine	GRIK1 RYR1 ITPR3	1.87e-04	98	26	3	CID000004507
Drug	indo-1	GRIK1 RYR1 ITPR3	1.93e-04	99	26	3	CID000105060
Drug	verapamil	APOB MSTN ABCA12 RYR1 ITPR3	2.05e-04	490	26	5	CID000002520
Drug	potassium hydroxide	APOB MSTN CAPN2	2.49e-04	108	26	3	CID000014797
Drug	Phosphatidylinositol 4,5-Diphosphate	TRPM7 CAPN2	2.60e-04	21	26	2	ctd:D019269
Drug	AC1L1CR9	RYR1 ITPR3	2.60e-04	21	26	2	CID000002023
Drug	lamotrigine	GRIK1 RYR1 ITPR3	3.08e-04	116	26	3	CID000003878
Drug	lithium chromate	SLC6A4 GRIK1 APOB ABCA12	3.34e-04	296	26	4	CID000026627
Drug	acetylleucyl-leucyl-norleucinal	APOB CAPN2	3.41e-04	24	26	2	ctd:C063261
Drug	fluo-3	GRIK1 RYR1 ITPR3	3.57e-04	122	26	3	CID000104978
Drug	T0702	RYR1 ITPR3	3.70e-04	25	26	2	CID000005908
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	SLC6A4 GRIK1 RYR1 ITPR3	3.88e-04	308	26	4	CID000001915
Drug	polyethylenimine	GLCE RYR1 ITPR3	4.11e-04	128	26	3	CID000009033
Drug	glycidamide	TRPM7 CAPN2 SIDT1	4.30e-04	130	26	3	ctd:C071834
Drug	Zinc Oxide	PRSS1 GRIK1 APOB MSTN	4.33e-04	317	26	4	ctd:D015034
Drug	5-deazariboflavin	FRRS1 RYR1	4.65e-04	28	26	2	CID000159867
Drug	BAPTA	GRIK1 TRPM7 RYR1 ITPR3	4.70e-04	324	26	4	CID000104751
Drug	pioglitazone	APOB MSTN RYR1 ITPR3	4.81e-04	326	26	4	CID000004829
Drug	lanthanum	TRPM7 RYR1 ITPR3	4.90e-04	136	26	3	CID000023926
Drug	HEPES	SLC6A4 PRSS1 GRIK1	4.90e-04	136	26	3	CID000023830
Drug	caged InsP3	RYR1 ITPR3	5.00e-04	29	26	2	CID000122248
Drug	AC1NUW3V	SLC6A4 GRIK1	5.00e-04	29	26	2	CID005462126
Drug	carvacrol	TRPM7 RYR1	5.00e-04	29	26	2	ctd:C073316
Drug	Dantrolene-13C3	GRIK1 RYR1 ITPR3	5.91e-04	145	26	3	CID000002951
Drug	nimodipine	GRIK1 RYR1 ITPR3	5.91e-04	145	26	3	CID000004497
Drug	benzothiophene	SLC6A4 FRRS1	6.09e-04	32	26	2	CID000007221
Drug	BAME	PRSS1 GLCE	6.09e-04	32	26	2	CID000150869
Drug	AC1L1D9C	SLC6A4 APOB MSTN CD96	6.21e-04	349	26	4	CID000002250
Drug	macrocyclic inhibitor 4	APOB MSTN	6.48e-04	33	26	2	CID016124959
Drug	CNS 1145	RYR1 ITPR3	6.48e-04	33	26	2	CID000190902
Drug	IHC-64	RYR1 ITPR3	6.48e-04	33	26	2	CID000162753
Drug	Soda	PRSS1 APOB	6.88e-04	34	26	2	CID000062596
Drug	PhTX-343	GRIK1 TRPM7	7.71e-04	36	26	2	CID000159548
Drug	4-chloro-m-cresol	RYR1 ITPR3	8.15e-04	37	26	2	CID000001732
Drug	AC1L98DX	RYR1 ITPR3	8.60e-04	38	26	2	CID000439957
Drug	valproate	GRIK1 PCDHGC3 RYR1 ITPR3	8.62e-04	381	26	4	CID000003121
Drug	NAADP	RYR1 ITPR3	9.05e-04	39	26	2	CID000123952
Drug	CID9959010	PCDHGC3 RYR1	9.05e-04	39	26	2	CID009959010
Drug	gabapentin	GRIK1 RYR1 ITPR3	9.21e-04	169	26	3	CID000003446
Drug	diisopropylamine	PRSS1 APOB	9.52e-04	40	26	2	CID000007912
Drug	Dantrolene	RYR1 CAPN2	1.00e-03	41	26	2	ctd:D003620
Drug	riluzole	GRIK1 RYR1 ITPR3	1.00e-03	174	26	3	CID000005070
Drug	TMB-8	MSTN RYR1 ITPR3	1.04e-03	176	26	3	CID000005494
Drug	carbamazepine	SLC6A4 GRIK1 APOB	1.09e-03	179	26	3	CID000002554
Drug	Pyoverdin	APOB RYR1	1.10e-03	43	26	2	CID005289234
Drug	LY341495	GRIK1 RYR1	1.10e-03	43	26	2	CID006324636
Disease	congestive heart failure (is_implicated_in)	SLC6A4 RYR1	2.59e-04	27	26	2	DOID:6000 (is_implicated_in)
Disease	Alcoholic Intoxication	SLC6A4 GRIK1	3.64e-04	32	26	2	C0001969
Disease	phosphatidylethanolamine measurement	APOB SIDT2 CD96	4.66e-04	173	26	3	EFO_0010228
Disease	cholesteryl ester 18:3 measurement	APOB SIDT2	5.70e-04	40	26	2	EFO_0010346
Disease	lipoprotein-associated phospholipase A(2) measurement	APOB GLCE	5.70e-04	40	26	2	EFO_0004746
Disease	ocular hypertension, response to triamcinolone acetonide	GRIK1 FRRS1	8.56e-04	49	26	2	EFO_0006954, EFO_1001069
Disease	response to statin	GRIK1 APOB	1.12e-03	56	26	2	GO_0036273
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	APOB ABCA12	1.69e-03	69	26	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	mean platelet volume	SLC6A4 SIRPB1 LY75 PCDHGC3 SIDT1	1.76e-03	1020	26	5	EFO_0004584

Protein segments in the cluster

Peptide	Gene	Start	Entry
AWVVFIAAFVKKLVY	ABCA12	1076	Q86UK0
ILDLVLYYNWKTVTV	GRIK1	161	P39086
LFYQKVIKYIWRIGT	GPR19	241	Q15760
TWVEKYFDVYGKVVQ	GLCE	131	O94923
WNYLYFIVLVRVKNK	ITPR3	2566	Q14573
KWYFIITIVIFVLQE	LCLAT1	371	Q6UWP7
YEDGIYSVIQKKVTW	LY75	1401	O60449
YSVIQKKVTWYEALN	LY75	1406	O60449
VVTVFGVIIFKVYKW	PCDHGC3	706	Q9UN70
VLKAVDSYIWVQFLY	GSAP	141	A4D1B5
WTVKYYELEEKIVSL	APOB	4396	P04114
QFLVTVVEKYKIYWV	FRRS1	141	Q6ZNA5
QLAKIKWVISVAFYV	GET1	96	O00258
EFYILWTKIQKYQKI	CAPN2	596	P17655
SIDVKYQIWKFGVIF	RYR1	4771	P21817
LIWKNYKKYIIIAFI	FER1L6	1816	Q2WGJ9
VLRKKYQIYFWNIAT	SIDT2	441	Q8NBJ9
IQYNKVVKAQLWIYL	MSTN	146	O14793
VLLVVGVSVIYVYWK	SIRPB1	381	Q5TFQ8
FYVWKRVFQRYETVK	ALG10	356	Q5BKT4
YYIIQIHFVKGVWEK	CD96	11	P40200
IVSKKYKIYFWNIIT	SIDT1	436	Q9NXL6
KIKYDWYQTESQVVI	SUGT1	171	Q9Y2Z0
KVYNYVKWIKNTIAA	PRSS1	231	P07477
LIFTVIYFSIWKGVK	SLC6A4	261	P31645
EWIVIAYIFTYAIEK	TRPM7	886	Q96QT4
KFIIIFYVKEWSLLY	TMC7	571	Q7Z402