Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Abnormal pericardium morphology	TSC2 TNFRSF1A FAS LYST IL23R	4.82e-05	82	26	5	HP:0001697
HumanPheno	AA amyloidosis	TNFRSF1A FAS IL23R	6.33e-05	16	26	3	HP:4000041
HumanPheno	Orchitis	TNFRSF1A FAS IL23R	6.33e-05	16	26	3	HP:0100796
HumanPheno	Amyloidosis	IL31RA TNFRSF1A FAS IL23R	1.05e-04	50	26	4	HP:0011034
Domain	ARM-type_fold	DNAJC13 CAND2 PIK3CB MROH2B CLTC HEATR9 TSC2 LYST	1.20e-04	339	82	8	IPR016024
Domain	TMEM132	TMEM132E TMEM132A	1.89e-04	5	82	2	PF16070
Domain	TMEM132D_N	TMEM132E TMEM132A	1.89e-04	5	82	2	PF15705
Domain	TMEM132D_C	TMEM132E TMEM132A	1.89e-04	5	82	2	PF15706
Domain	TMEM132_M	TMEM132E TMEM132A	1.89e-04	5	82	2	IPR031437
Domain	TMEM132_C	TMEM132E TMEM132A	1.89e-04	5	82	2	IPR031436
Domain	TMEM132_N	TMEM132E TMEM132A	1.89e-04	5	82	2	IPR031435
Domain	TMEM132	TMEM132E TMEM132A	1.89e-04	5	82	2	IPR026307
Domain	DEATH	TNFRSF1A FAS UNC5D	2.21e-04	27	82	3	SM00005
Domain	Death	TNFRSF1A FAS UNC5D	4.05e-04	33	82	3	PF00531
Domain	Death_domain	TNFRSF1A FAS UNC5D	6.16e-04	38	82	3	IPR000488
Domain	DEATH_DOMAIN	TNFRSF1A FAS UNC5D	6.16e-04	38	82	3	PS50017
Domain	IL6Ra-bind	IL12RB2 IL31RA	1.02e-03	11	82	2	PF09240
Domain	TypeI_recpt_CBD	IL12RB2 IL31RA	1.02e-03	11	82	2	IPR015321
Domain	-	NPHP3 OGT ERCC6L CLTC KDM6B	2.18e-03	207	82	5	1.25.40.10
Domain	-	DNAJC13 CAND2 MROH2B HEATR9 TSC2	2.95e-03	222	82	5	1.25.10.10
Domain	TPR-like_helical_dom	NPHP3 OGT ERCC6L CLTC KDM6B	3.62e-03	233	82	5	IPR011990
Domain	TNFR_c6	TNFRSF1A FAS	4.15e-03	22	82	2	PF00020
Domain	JmjC	KDM2A KDM6B	4.94e-03	24	82	2	PF02373
Pubmed	The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.	RIPK3 TNFRSF1A FAS	1.85e-06	10	88	3	22000287
Pubmed	Immune effectors required for hepatitis B virus clearance.	TNFRSF1A FAS LYST	1.85e-06	10	88	3	20080755
Pubmed	RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.	RIPK3 TNFRSF1A FAS	2.55e-06	11	88	3	30988397
Pubmed	TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells.	RIPK3 TNFRSF1A FAS	4.40e-06	13	88	3	35417681
Pubmed	NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.	RIPK3 TNFRSF1A FAS	4.40e-06	13	88	3	26982364
Pubmed	T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.	RIPK3 TNFRSF1A FAS	5.58e-06	14	88	3	31848486
Pubmed	Homology between reaper and the cell death domains of Fas and TNFR1.	TNFRSF1A FAS	6.33e-06	2	88	2	7537635
Pubmed	Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway.	TNFRSF1A FAS	6.33e-06	2	88	2	28115640
Pubmed	Role of rs1343151 IL23R and rs3790567 IL12RB2 polymorphisms in biopsy-proven giant cell arteritis.	IL12RB2 IL23R	6.33e-06	2	88	2	21285166
Pubmed	Various Forms of Programmed Cell Death Are Concurrently Activated in the Population of Retinal Ganglion Cells after Ischemia and Reperfusion.	TNFRSF1A FAS	6.33e-06	2	88	2	37373037
Pubmed	Autoimmune kidney disease and lymphadenopathy in NODlpr mice are not modified by deficiency in tumor necrosis factor receptor 1 or beta 2-microglobulin.	TNFRSF1A FAS	6.33e-06	2	88	2	12750352
Pubmed	Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity.	PRKCD TSC2	6.33e-06	2	88	2	30684133
Pubmed	Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice.	FAS IL23R	6.33e-06	2	88	2	20308633
Pubmed	Apoptotic mechanisms in fulminant hepatic failure: potential therapeutic target.	TNFRSF1A FAS	6.33e-06	2	88	2	19077906
Pubmed	[Relationship between myocardial modelling and diastolic function in patients with essential hypertension].	TNFRSF1A FAS	6.33e-06	2	88	2	22036455
Pubmed	An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.	IL12RB2 IL23R	6.33e-06	2	88	2	26916345
Pubmed	Increased IL-23 receptor, TNF-α and IL-6 expression in individuals with the IL23R-IL12RB2 locus polymorphism.	IL12RB2 IL23R	6.33e-06	2	88	2	24434271
Pubmed	Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection.	TNFRSF1A FAS	6.33e-06	2	88	2	15619234
Pubmed	TNFR1 Regulates Ovarian Cancer Cell Tumorigenicity Through PIK3CB-p110Beta.	PIK3CB TNFRSF1A	6.33e-06	2	88	2	26122654
Pubmed	Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.	TNFRSF1A FAS	6.33e-06	2	88	2	15972661
Pubmed	Apoptosis mediated by Fas but not tumor necrosis factor receptor 1 prevents chronic disease in mice infected with murine cytomegalovirus.	TNFRSF1A FAS	6.33e-06	2	88	2	9769336
Pubmed	Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I.	TNFRSF1A FAS	6.33e-06	2	88	2	8609380
Pubmed	Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation.	RIPK3 FAS	6.33e-06	2	88	2	31133359
Pubmed	Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation.	RIPK3 PRKCD	6.33e-06	2	88	2	25563840
Pubmed	Fas bridging cell death and cytotoxicity: the reaper connection.	TNFRSF1A FAS	6.33e-06	2	88	2	7493759
Pubmed	TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions.	TNFRSF1A FAS	6.33e-06	2	88	2	10671227
Pubmed	Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis.	RIPK3 TNFRSF1A	1.90e-05	3	88	2	27362805
Pubmed	Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.	IL12RB2 IL23R	1.90e-05	3	88	2	20622879
Pubmed	RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death.	TNFRSF1A FAS	1.90e-05	3	88	2	7538908
Pubmed	Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behçet's disease.	IL12RB2 IL23R	1.90e-05	3	88	2	22378604
Pubmed	CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.	TNFRSF1A FAS	1.90e-05	3	88	2	15744305
Pubmed	Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists.	TNFRSF1A FAS	1.90e-05	3	88	2	15611291
Pubmed	Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis.	TNFRSF1A FAS	1.90e-05	3	88	2	9125577
Pubmed	Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8.	RIPK3 TNFRSF1A	1.90e-05	3	88	2	24036366
Pubmed	RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.	RIPK3 TSC2	1.90e-05	3	88	2	27984090
Pubmed	Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils.	PRKCD TNFRSF1A	1.90e-05	3	88	2	11078718
Pubmed	The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand.	CLTC FAS	1.90e-05	3	88	2	18670435
Pubmed	Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment.	ITGA6 PRKCD	1.90e-05	3	88	2	11389095
Pubmed	Involvement of tumor necrosis factor-alpha receptor 1 and tumor necrosis factor-related apoptosis-inducing ligand-(TRAIL) receptor-2/DR-5, but not Fas, in graft injury in live-donor liver transplantation.	TNFRSF1A FAS	1.90e-05	3	88	2	15502938
Pubmed	Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis.	RIPK3 TNFRSF1A	1.90e-05	3	88	2	28572508
Pubmed	Apoptotic signaling through Fas and TNF receptors ameliorates GVHD in mobilized peripheral blood grafts.	TNFRSF1A FAS	1.90e-05	3	88	2	24566711
Pubmed	Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML.	RIPK3 TNFRSF1A	1.90e-05	3	88	2	24842373
Pubmed	Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy.	IL12RB2 IL23R	1.90e-05	3	88	2	33287915
Pubmed	Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways.	TNFRSF1A FAS	1.90e-05	3	88	2	12706861
Pubmed	The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis.	TNFRSF1A FAS	1.90e-05	3	88	2	28120397
Pubmed	The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.	RIPK3 TNFRSF1A	1.90e-05	3	88	2	27160902
Pubmed	Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma.	ITGA6 TNFRSF1A	1.90e-05	3	88	2	22396498
Pubmed	Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice.	FAS LYST	1.90e-05	3	88	2	11359810
Pubmed	Lysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts.	PIK3CB PRKCD	1.90e-05	3	88	2	23252604
Pubmed	Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners.	RIPK3 TNFRSF1A	1.90e-05	3	88	2	33311474
Pubmed	Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese.	IL12RB2 IL23R	1.90e-05	3	88	2	27464962
Pubmed	A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.	TNFRSF1A FAS	1.90e-05	3	88	2	15465831
Pubmed	TNF receptor 2-deficient CD8 T cells are resistant to Fas/Fas ligand-induced cell death.	TNFRSF1A FAS	1.90e-05	3	88	2	11046004
Pubmed	Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages.	TNFRSF1A FAS	1.90e-05	3	88	2	17692826
Pubmed	H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3.	IL12RB2 KDM6B	1.90e-05	3	88	2	28947543
Pubmed	Influence of the lpr environment on the lymph node cell phenotypes in C57BL/6 nubg and nulpr chimeras.	FAS LYST	1.90e-05	3	88	2	7875735
Pubmed	Regulation of Fas ligand-induced apoptosis by TNF.	TNFRSF1A FAS	3.79e-05	4	88	2	11544288
Pubmed	Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection.	TNFRSF1A FAS	3.79e-05	4	88	2	11752172
Pubmed	Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis.	TNFRSF1A FAS	3.79e-05	4	88	2	16237080
Pubmed	Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.	IL12RB2 IL23R	3.79e-05	4	88	2	20622878
Pubmed	Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo.	TNFRSF1A FAS	3.79e-05	4	88	2	19050279
Pubmed	Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	26817517
Pubmed	Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation.	TNFRSF1A FAS	3.79e-05	4	88	2	12736263
Pubmed	Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice.	TNFRSF1A FAS	3.79e-05	4	88	2	24303082
Pubmed	Fas-mediated neutrophil apoptosis and associated A1 protein expression during systemic inflammation are regulated independently of both tumor necrosis factor receptors.	TNFRSF1A FAS	3.79e-05	4	88	2	12630518
Pubmed	TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes.	TNFRSF1A FAS	3.79e-05	4	88	2	10657611
Pubmed	Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.	TNFRSF1A FAS	3.79e-05	4	88	2	8906799
Pubmed	Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	34919140
Pubmed	Differential regulation of alpha6beta4 integrin by PKC isoforms in murine skin keratinocytes.	ITGA6 PRKCD	3.79e-05	4	88	2	14715240
Pubmed	Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	14749364
Pubmed	Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	10339433
Pubmed	Death receptors mediate the adverse effects of febrile-range hyperthermia on the outcome of lipopolysaccharide-induced lung injury.	TNFRSF1A FAS	3.79e-05	4	88	2	21515659
Pubmed	Lupus serum IgG induces skin inflammation through the TNFR1 signaling pathway.	TNFRSF1A FAS	3.79e-05	4	88	2	20483718
Pubmed	The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	22817896
Pubmed	Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	28387756
Pubmed	Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils.	TNFRSF1A FAS	3.79e-05	4	88	2	11786908
Pubmed	Protein kinase Cepsilon inhibits UVR-induced expression of FADD, an adaptor protein, linked to both Fas- and TNFR1-mediated apoptosis.	TNFRSF1A FAS	3.79e-05	4	88	2	19194472
Pubmed	Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling.	TNFRSF1A FAS	3.79e-05	4	88	2	9045686
Pubmed	Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.	PIK3CB PRKCD	3.79e-05	4	88	2	11676480
Pubmed	Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.	CYP4V2 ABO	3.79e-05	4	88	2	19278955
Pubmed	The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.	TNFRSF1A FAS	3.79e-05	4	88	2	15858021
Pubmed	Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.	RIPK3 TNFRSF1A	3.79e-05	4	88	2	29661823
Pubmed	IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus.	FAS IL23R	3.79e-05	4	88	2	28646040
Pubmed	Effector CD4+ T cell expression signatures and immune-mediated disease associated genes.	IL12RB2 IL23R	3.79e-05	4	88	2	22715389
Pubmed	Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.	DSCAM ITGA6 UNC5D	6.05e-05	30	88	3	32562661
Pubmed	Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.	TNFRSF1A FAS	6.30e-05	5	88	2	15289505
Pubmed	Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules.	TNFRSF1A FAS	6.30e-05	5	88	2	10946317
Pubmed	Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis.	PRKCD FAS	6.30e-05	5	88	2	27422101
Pubmed	Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.	TNFRSF1A MAP4K4	6.30e-05	5	88	2	17500068
Pubmed	Both the Fas ligand and inducible nitric oxide synthase are needed for control of parasite replication within lesions in mice infected with Leishmania major whereas the contribution of tumor necrosis factor is minimal.	TNFRSF1A FAS	6.30e-05	5	88	2	12933876
Pubmed	RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis.	RIPK3 TNFRSF1A	6.30e-05	5	88	2	25186904
Pubmed	Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.	KDM6B FAS	6.30e-05	5	88	2	26544625
Pubmed	TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules.	TMEM132E TMEM132A	6.30e-05	5	88	2	29088312
Pubmed	F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis.	TNFRSF1A FAS	6.30e-05	5	88	2	10542291
Pubmed	Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF.	TNFRSF1A FAS	6.30e-05	5	88	2	9820556
Pubmed	The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.	RIPK3 TNFRSF1A	6.30e-05	5	88	2	29434332
Pubmed	Daxx, a novel Fas-binding protein that activates JNK and apoptosis.	TNFRSF1A FAS	6.30e-05	5	88	2	9215629
Pubmed	O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.	OGT RIPK3	6.30e-05	5	88	2	30770249
Pubmed	The FLIP Side of Life.	TNFRSF1A FAS	6.30e-05	5	88	2	23322903
Pubmed	The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation.	IL12RB2 IL23R	6.30e-05	5	88	2	24586521
Cytoband	Xq13.1	ERCC6L NHSL2 CXorf65	1.07e-04	48	87	3	Xq13.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq13	OGT ERCC6L NHSL2 CXorf65	2.84e-04	165	87	4	chrXq13
Cytoband	17q12	TMEM132E MYO19 HEATR9	9.04e-04	99	87	3	17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr3q22	DNAJC13 NPHP3 PIK3CB	2.20e-03	135	87	3	chr3q22
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TMEM132E MYO19 HEATR9	2.91e-03	149	87	3	chr17q12
Cytoband	3q22.1	DNAJC13 NPHP3	2.91e-03	42	87	2	3q22.1
Cytoband	12p13.2	STYK1 TNFRSF1A	3.33e-03	45	87	2	12p13.2
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	PKMYT1 ERCC6L SLC10A5 PEG10 STYK1 GINS2 SCIN	4.95e-08	175	86	7	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	PKMYT1 ERCC6L SLC10A5 PEG10 STYK1 GINS2 SCIN	4.95e-08	175	86	7	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC7A8 NWD1 ZDHHC23 ERCC6L APOBEC1	1.52e-05	161	86	5	8937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like-ILC3\|blood / Manually curated celltypes from each tissue	ZDHHC23 PRSS12 STYK1 SCIN TFR2	1.71e-05	165	86	5	f012a27ece54c0f7b73a2f4f89c6ee8b865f8782
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CAND2 UBE3D STYK1 NCCRP1	1.94e-05	82	86	4	01a4d47d9e0dee68a5277ed1534338cec80f75d1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cadm2_(Cadm2_state)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CAND2 UBE3D STYK1 NCCRP1	1.94e-05	82	86	4	c1489097c291f413f3cfa5e26f8182ec872328fd
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B NPHP3 DSCAM APOBEC1 SCIN	2.09e-05	172	86	5	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B NPHP3 DSCAM APOBEC1 SCIN	2.09e-05	172	86	5	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B NPHP3 DSCAM APOBEC1 SCIN	2.09e-05	172	86	5	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	IL12RB2 DNAJC13 ZDHHC23 LYST IL23R	2.40e-05	177	86	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD RADIL NHSL2 TNFRSF1A SEC14L1	2.46e-05	178	86	5	375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell	PBMC-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	PKMYT1 SLC7A8 NWD1 MYO19 GINS2	2.74e-05	182	86	5	4774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JCAD NPR3 TMEM132A ITGA6 SEC14L1	3.62e-05	193	86	5	ff6e6b825d6c88148216c601580be3c28851ab5c
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Venous_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	JCAD NPR3 NHSL2 ITGA6 RASSF9	3.81e-05	195	86	5	cc3d6f98d310e8840ff497d7258c5ccf54e6c624
ToppCell	distal-2-Hematologic-Proliferating_NK/T\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PKMYT1 DDX12P ERCC6L GINS2 CXorf65	4.09e-05	198	86	5	a5fd710df5669c95fc5b5ef6e5cfafe6687c7b72
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	PKMYT1 ERCC6L PEG10 MYO19 GINS2	4.19e-05	199	86	5	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DOK5 DSCAM NHSL2 ITGA6 GINS2	4.29e-05	200	86	5	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIPK3 HEATR9 STYK1 CXorf65	1.56e-04	140	86	4	568a008ff103269e9fe36aa95e9d302641efed98
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIPK3 HEATR9 STYK1 CXorf65	1.65e-04	142	86	4	c2a3cd9998fd9a8e6b2665347ca5c32511776488
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	JCAD PTPDC1 ABO RASSF9	1.70e-04	143	86	4	ce045ec7c311a1797ae562bec114f9e90604d063
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CYP4V2 SLC7A8 FAM151A MARCHF6	1.79e-04	145	86	4	47a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RIPK3 HEATR9 STYK1 CXorf65	1.79e-04	145	86	4	23a1ee986774725a9f5a9154fbbd023031fb0452
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK5 RADIL DSCAM UBE3D	2.04e-04	150	86	4	47ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell	droplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAM151A STYK1 GRM6 TFR2	2.14e-04	152	86	4	0fda8980b10ce16179dea92301db74d728f41794
ToppCell	droplet-Lung-nan-3m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR157 TMEM132A SCIN NCCRP1	2.14e-04	152	86	4	77b319f594d5e4df29034bbf69c7490076f89dd3
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JCAD RADIL CAND2 TMEM132A	2.25e-04	154	86	4	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|Heart / Disease (COVID-19 only), tissue and cell type	SLC7A8 IL12RB2 GPR157 ITIH6	2.31e-04	155	86	4	d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell	facs-MAT-Fat-24m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3CB PRKCD APOBEC1 NCCRP1	2.31e-04	155	86	4	d0c1608f8f6b6f4174e51d610501c707cba5e015
ToppCell	10x5'-bone_marrow-Lymphocytic_B-GC_B_(I)\|bone_marrow / Manually curated celltypes from each tissue	PKMYT1 PEG10 GINS2 CCDC168	2.43e-04	157	86	4	d4da4057917dda066da0f2aac2621fdaf1fb943b
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RADIL HTR7 PRKCD SCIN	2.49e-04	158	86	4	bd37d567754b660bfff7aef81cb307a384ec20a0
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC7A8 ZDHHC23 CLTC APOBEC1	2.55e-04	159	86	4	c0e55f25271f788c08fa4b95186501fc27b2ec39
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL31RA ERCC6L PRKCD APOBEC1	2.61e-04	160	86	4	2020b6defbaf5b5db12af37f0103ac028a8ca76e
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL31RA ERCC6L PRKCD APOBEC1	2.61e-04	160	86	4	af7cf0dc5fe7c02f7d6c436f6dde766c79ff0eae
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC7A8 IL12RB2 HEATR9 STYK1	2.73e-04	162	86	4	04ccd3d216f8f41afd3434a61264f03d6324db35
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1A1 ERCC6L GPR157 CXorf65	2.73e-04	162	86	4	04a96442e0fcdb6a65b9e45044021677f9f53d38
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1A1 ERCC6L GPR157 CXorf65	2.73e-04	162	86	4	7adb3e279526e1f21033c10af0a0058258f21842
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B MYO19 STYK1 FAS	2.80e-04	163	86	4	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	E17.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC7A8 CLTC APOBEC1 PGAP6	2.86e-04	164	86	4	4e9de41ea10ce3233c09e144bfc0453c0ae79fd3
ToppCell	E17.5-Endothelial-lymphatic_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SLC7A8 CLTC APOBEC1 PGAP6	2.86e-04	164	86	4	6f4914b0ac282b4b9f6111930a82515178c1bc80
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	NPR3 ABO SLC10A5 TFR2	3.00e-04	166	86	4	a853005a5587d42daecdf2e23a93109919021a4f
ToppCell	droplet-Lung-LUNG-1m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 GINS2 SCIN NCCRP1	3.07e-04	167	86	4	e30e7ac8ea4399dc3c1d94fc6b857afc80a7a671
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	DENND5B PEG10 TMEM132A MAP4K4	3.14e-04	168	86	4	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	droplet-Fat-Scat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A8 PRKCD APOBEC1 PGAP6	3.14e-04	168	86	4	749eccebe4ee066f827d2a3980512f195f23ac27
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CYP1A1 KDM2A FAS	3.14e-04	168	86	4	3bddf411a60137a8883fc9e77586e4719b0d6067
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ABO KNDC1 SCIN IL23R	3.14e-04	168	86	4	e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	DENND5B PEG10 TMEM132A MAP4K4	3.14e-04	168	86	4	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell	facs-Heart-RV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CYP1A1 ITGA6 RASSF9	3.14e-04	168	86	4	831b000e26b4a7e7fdfa3988372e0281c45eadbb
ToppCell	droplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC7A8 PEG10 GRM6 SCIN	3.14e-04	168	86	4	0e99ecd94ab8e5372e30433d7d0aa76b4d54257a
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CYP1A1 KDM2A FAS	3.14e-04	168	86	4	b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell	droplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC7A8 PEG10 GRM6 SCIN	3.14e-04	168	86	4	34722e14f28313f2e4644b3c1861ef12958cee9f
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ABO KNDC1 SCIN IL23R	3.14e-04	168	86	4	403aba73a0f9ffb32252288d075fad8a588ca440
ToppCell	droplet-Lung-nan-18m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A8 PEG10 GRM6 SCIN	3.21e-04	169	86	4	f2e20049a17eee533d49bd5f24a51962d123d132
ToppCell	droplet-Lung-nan-18m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A8 PEG10 GRM6 SCIN	3.21e-04	169	86	4	4c6892551e9dec94fc62b3beab1e6d424639a1e9
ToppCell	facs-BAT-Fat-3m-Myeloid-granulocyte\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP32 TMEM132A TNFRSF1A LYST	3.28e-04	170	86	4	8fd0a55266066a51266ab616c38c883e2680bcf4
ToppCell	droplet-Lung-LUNG-30m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 ZDHHC23 NCCRP1 CHRNB4	3.28e-04	170	86	4	ece7c20e89c190a7ec68032b6c2efeb458c43f9a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	JCAD PRSS12 FSTL4 UNC5D	3.28e-04	170	86	4	5de2f7d16a05af74ebfb1ca42d0f9c3c3524692d
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 PIK3CB NCCRP1 CHRNB4	3.43e-04	172	86	4	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PKMYT1 MED14 GINS2 APOBEC1	3.43e-04	172	86	4	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM151A GRM6 SCIN TFR2	3.51e-04	173	86	4	4f849d236ee358ad30ac977745ac43c8e9778e94
ToppCell	droplet-Lung-LUNG-30m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM151A GRM6 SCIN TFR2	3.51e-04	173	86	4	39c3b8313354c4c60764597507a2505dcfa4e8c7
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PKMYT1 ERCC6L SLC10A5 STYK1	3.51e-04	173	86	4	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	droplet-Thymus-nan-3m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A8 TMEM132A KNDC1 NCCRP1	3.51e-04	173	86	4	63f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PKMYT1 ERCC6L SLC10A5 STYK1	3.51e-04	173	86	4	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKMYT1 ERCC6L UBE3D GINS2	3.51e-04	173	86	4	20a20429aa898097d5ec4880ed64846558b5890f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	JCAD PRSS12 CCDC168 UNC5D	3.58e-04	174	86	4	b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS12 STYK1 CCDC168 UNC5D	3.58e-04	174	86	4	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	Control-B_cells-Plasma_cells\|Control / group, cell type (main and fine annotations)	DENND5B OGT ITGA6 SEC14L1	3.66e-04	175	86	4	fb23858cfce71509cafbe0d9728e678012ff2962
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP4V2 RADIL METTL8 UNC5D	3.66e-04	175	86	4	96219e58dcb327fd27190be78193e7a0d611e62b
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP4V2 RADIL METTL8 UNC5D	3.66e-04	175	86	4	cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A8 NPR3 UBE3D SEC14L1	3.74e-04	176	86	4	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PRSS12 STYK1 CCDC168 UNC5D	3.82e-04	177	86	4	f902600c639087664316b3cf30cab243bc3d1c5c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAM ITGA6 PRKCD SCIN	3.82e-04	177	86	4	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	facs-Marrow-KLS-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 PIK3CB GPR157 NCCRP1	3.91e-04	178	86	4	6bad4439a1692332f70135ff446a1048fa4c399d
ToppCell	facs-Marrow-KLS-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HTR7 PIK3CB GPR157 NCCRP1	3.91e-04	178	86	4	3f6feb4ed7779cf5684f52939350b41d7718c3c6
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RADIL PEG10 RASSF9 NCCRP1	3.99e-04	179	86	4	40c65e8623547aeb80f9cd2366e29072467ce069
ToppCell	COVID-19_Mild-NK_CD56bright\|COVID-19_Mild / Disease condition and Cell class	IL12RB2 STYK1 LYST SEC14L1	3.99e-04	179	86	4	90e7a4af195aa2332b07a9f06cde63e72ff49255
ToppCell	facs-Heart-RV-24m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CYP1A1 ITGA6 RASSF9	3.99e-04	179	86	4	6aa211670e5d6e013d0980967aa0a4f8f2905efe
ToppCell	facs-Heart-RV-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CYP1A1 ITGA6 RASSF9	3.99e-04	179	86	4	cf4d3828a3ce97932c68d06f5c65a070fc6d832c
ToppCell	facs-Heart-RV-24m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B CYP1A1 ITGA6 RASSF9	3.99e-04	179	86	4	f9bc76ff25f88ee44c72499a0df9dc16f519c4cb
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-0\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B DOK5 METTL8 SCIN	3.99e-04	179	86	4	fce1ba53815145f6248d4e90aedca3dad84e33e4
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RADIL NPR3 ABO TFR2	4.07e-04	180	86	4	f598bb9df0d784120847fada2d9a2a88b8b68cd1
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP4V2 ERCC6L FSTL4 IL23R	4.07e-04	180	86	4	5fdd10ffdf49f0e818f865ca095a3882b35c640e
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RADIL NPR3 ABO TFR2	4.07e-04	180	86	4	b4fa047f271c7b56940bdc85c912f50aa5b5ca82
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKMYT1 ERCC6L GINS2 CXorf65	4.16e-04	181	86	4	73b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	PIK3CB USP32 CLTC LYST	4.16e-04	181	86	4	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JCAD NPR3 ITGA6 RASSF9	4.34e-04	183	86	4	c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCell	COVID-19_Moderate-HSPC\|World / disease group, cell group and cell class	NPR3 ABO RASSF9 TFR2	4.43e-04	184	86	4	ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCell	Bac-SEP-Lymphocyte-T_NK-T_NK_proliferative\|Bac-SEP / Disease, Lineage and Cell Type	PKMYT1 IL12RB2 ERCC6L GINS2	4.43e-04	184	86	4	848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)--\|Striatum / BrainAtlas - Mouse McCarroll V32	CYP1A1 IL23R NCCRP1	4.45e-04	77	86	3	7bb18406d404c51ee938cc577c155dc51868ddb9
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)\|Striatum / BrainAtlas - Mouse McCarroll V32	CYP1A1 IL23R NCCRP1	4.45e-04	77	86	3	ac311740424ff75b478b3c19fa0fae93776eb54e
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	CYP1A1 IL23R NCCRP1	4.45e-04	77	86	3	9f2dbf922acb905d636427a766a217c0db9671d2
ToppCell	COVID-19_Moderate-HSPC\|COVID-19_Moderate / disease group, cell group and cell class	NPR3 ABO RASSF9 TFR2	4.52e-04	185	86	4	cacc6ab5f26f6c803894567fb838ea06eaa7efe5
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DSCAM ZDHHC23 STYK1 FSTL4	4.61e-04	186	86	4	84ba666237c18189d7e7556bd92dd953af733c00
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	CYP1A1 JCAD TMEM132A ITGA6	4.61e-04	186	86	4	f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NPR3 ITGA6 RASSF9 LYST	4.61e-04	186	86	4	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	JCAD NPR3 TMEM132A ITGA6	4.61e-04	186	86	4	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	JCAD NPR3 TMEM132A ITGA6	4.61e-04	186	86	4	c3449e54454009973818fc1101933c6f0168258c
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT10 MIA3 ABO SCIN	4.61e-04	186	86	4	32d30f08b20a0a28e38b37bd52ab26d1d43736ce
ToppCell	356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|356C / Donor, Lineage, Cell class and subclass (all cells)	CYP1A1 JCAD TMEM132A ITGA6	4.61e-04	186	86	4	2b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GALNT10 NPHP3 KDM2A SEC14L1	4.70e-04	187	86	4	0099def970fbc828756fbf853eca2ce77b8cd342
Disease	Hyperoxia	CYP1A1 TNFRSF1A	2.28e-05	3	82	2	C0242706
Disease	multiple sclerosis (is_implicated_in)	TNFRSF1A FAS NDUFS2 IL23R	5.21e-05	73	82	4	DOID:2377 (is_implicated_in)
Disease	X-11423--O-sulfo-L-tyrosine measurement	PKMYT1 ABO	1.14e-04	6	82	2	EFO_0021231
Disease	oral cavity cancer (is_implicated_in)	CYP1A1 CHRNB4	1.14e-04	6	82	2	DOID:8618 (is_implicated_in)
Disease	ankylosing spondylitis	IL12RB2 TNFRSF1A FAS IL23R	1.23e-04	91	82	4	EFO_0003898
Disease	tumor necrosis factor receptor superfamily member 6 measurement	ABO FAS	1.59e-04	7	82	2	EFO_0010610
Disease	Autoimmune Lymphoproliferative Syndrome	PRKCD FAS	2.11e-04	8	82	2	C1328840
Disease	Streptozotocin Diabetes	CYP1A1 PRKCD TNFRSF1A FAS	2.38e-04	108	82	4	C0038433
Disease	Diabetes Mellitus, Experimental	CYP1A1 PRKCD TNFRSF1A FAS	2.38e-04	108	82	4	C0011853
Disease	Alloxan Diabetes	CYP1A1 PRKCD TNFRSF1A FAS	2.38e-04	108	82	4	C0002152
Disease	disorder of pharynx	MIA3 IL23R CCDC188	2.88e-04	46	82	3	MONDO_0020592
Disease	systemic lupus erythematosus (is_marker_for)	TNFRSF1A FAS IL23R	3.07e-04	47	82	3	DOID:9074 (is_marker_for)
Disease	renal cell carcinoma (is_marker_for)	CYP1A1 TNFRSF1A KDM6B FAS	4.55e-04	128	82	4	DOID:4450 (is_marker_for)
Disease	Diffuse Large B-Cell Lymphoma	PIK3CB CLTC FAS	4.89e-04	55	82	3	C0079744
Disease	rheumatoid arthritis (is_implicated_in)	TNFRSF1A FAS IL23R	5.72e-04	58	82	3	DOID:7148 (is_implicated_in)
Disease	uveitis (is_implicated_in)	TNFRSF1A IL23R	5.83e-04	13	82	2	DOID:13141 (is_implicated_in)
Disease	Coronary Arteriosclerosis	JCAD MIA3 ABO	7.98e-04	65	82	3	C0010054
Disease	Coronary Artery Disease	JCAD MIA3 ABO	7.98e-04	65	82	3	C1956346
Disease	pneumonia (is_implicated_in)	CYP1A1 ABO	8.93e-04	16	82	2	DOID:552 (is_implicated_in)
Disease	response to ketamine	MROH2B METTL8 CCDC188	9.50e-04	69	82	3	EFO_0009748
Disease	pulse pressure measurement, alcohol drinking	JCAD NPR3 UNC5D	9.90e-04	70	82	3	EFO_0004329, EFO_0005763
Disease	acute kidney failure (is_marker_for)	TNFRSF1A FAS	1.01e-03	17	82	2	DOID:3021 (is_marker_for)
Disease	ankylosing spondylitis (is_implicated_in)	CYP1A1 IL23R	1.27e-03	19	82	2	DOID:7147 (is_implicated_in)
Disease	small cell lung carcinoma	FSTL4 SCIN CHRNB4	1.46e-03	80	82	3	EFO_0000702
Disease	ST2 protein measurement	ABO MAP4K4	1.55e-03	21	82	2	EFO_0010599
Disease	chronic myeloid leukemia (is_implicated_in)	CYP1A1 FAS	1.55e-03	21	82	2	DOID:8552 (is_implicated_in)
Disease	hepatitis B (is_marker_for)	FAS MAP4K4	1.55e-03	21	82	2	DOID:2043 (is_marker_for)
Disease	Lung Injury	CYP1A1 TNFRSF1A	1.55e-03	21	82	2	C0273115
Disease	Chronic Lung Injury	CYP1A1 TNFRSF1A	1.55e-03	21	82	2	C2350344
Disease	anxiety disorder (implicated_via_orthology)	HTR7 TSC2	1.70e-03	22	82	2	DOID:2030 (implicated_via_orthology)
Disease	lung adenocarcinoma (is_marker_for)	FAS MAP4K4 CHRNB4	1.73e-03	85	82	3	DOID:3910 (is_marker_for)
Disease	Sjogren's syndrome (is_marker_for)	FAS IL23R	2.02e-03	24	82	2	DOID:12894 (is_marker_for)
Disease	Behcet Syndrome	FAS IL23R	2.02e-03	24	82	2	C0004943
Disease	large artery stroke, coronary artery disease	ABO CHRNB4	2.20e-03	25	82	2	EFO_0001645, EFO_0005524
Disease	adult respiratory distress syndrome (is_marker_for)	RIPK3 TNFRSF1A	2.37e-03	26	82	2	DOID:11394 (is_marker_for)
Disease	cystic fibrosis (is_implicated_in)	CYP1A1 FAS	2.56e-03	27	82	2	DOID:1485 (is_implicated_in)
Disease	peak expiratory flow	CYP1A1 JCAD PTPDC1 NPR3 ABO KDM2A	2.66e-03	498	82	6	EFO_0009718

Protein segments in the cluster

Peptide	Gene	Start	Entry
NILRIPAKRIWLPDI	CHRNB4	101	P30926
RKDVLVVTPWLAPIV	ABO	81	P16442
PLLKNPEPWLLVALR	CXorf65	96	A6NEN9
ILSLPPCLKISRRWQ	APOBEC1	186	P41238
GPEPLSLLQKLILWR	DNHD1	4031	Q96M86
SLLQKLILWRVLRPE	DNHD1	4036	Q96M86
PWGPLKLRIDENRIV	NPR3	451	P17342
KELLRFPPLLWVRLR	NWD1	621	Q149M9
SERVLPPLTRILKLW	RASSF9	86	O75901
LPVPLWRTAEAKLVQ	RASSF9	121	O75901
RPWPAVAIALLALLV	PYY3	6	Q5JQD4
LVFWVIRASRPQVPK	CYP1A1	21	P04798
QIVLRWKKPDIPRPI	SLC7A8	406	Q9UHI5
LLIQELWKPREGLSR	RADIL	141	Q96JH8
PRLLWERVEKLVPRP	MAP4K4	661	O95819
VLPACLPLWRERPQK	PRSS12	746	P56730
QKLRPRRWKLQVLDL	PRAMEF17	91	Q5VTA0
PVRLLWKKARGAPVL	IL31RA	246	Q8NI17
INWTLLEKRRLEPPF	PRKCD	606	Q05655
PLQTRLLEAIIRLWP	MYO19	851	Q96H55
WLPPLLDRIARNRKT	GALNT10	246	Q86SR1
LKPVSRRPWDLISQL	JCAD	821	Q9P266
LIRLLNELLPWEPKL	KIAA2026	811	Q5HYC2
IVRPLPPWDIRIKFQ	IL12RB2	221	Q99665
RAKVLPPLEQVWNLL	KDM6B	166	O15054
LPQRLTWKLLLLRRP	NCCRP1	86	Q6ZVX7
ALLLERWILEPVPRQ	FAM214A	121	Q32MH5
NGIPLRIKDWPILVE	PEG10	386	Q86TG7
WLPIRIIKSVLPNFL	MARCHF6	496	O60337
LKRQKGERLRLPPWL	LIAS	66	O43766
NPRVKLISWPLSALR	DOK5	171	Q9P104
LWLQDNIRDKLRPIP	ITGA6	606	P23229
RVPPDAVLLRWLLQV	PGAP6	71	Q9HCN3
PLWKRRNVECLQPLT	PTPDC1	371	A2A3K4
EKLLNIRPPPRAQWI	NDUFS2	156	O75306
WERPPLQLLEQALRK	TENT4A	286	Q5XG87
PDVPWRLLKLEILVE	MED14	241	O60244
RAREPLLVALLPLAW	GRM6	6	O15303
PLLRTLDLRWAVGIK	KDM2A	1001	Q9Y2K7
VRRPIWINADILKGP	FAM151A	166	Q8WW52
LVPPLLSRATVWKLR	CCDC188	371	H7C350
LRPPIIWKRNGLTLN	FSTL4	276	Q6MZW2
RTGIKRRILLLIPKW	IL23R	381	Q5VWK5
KLVLIPLIFIGLRVW	GPR157	226	Q5UAW9
RPPVLAKLPAWIRAR	DDX12P	886	Q92771
LGTRDRLLPQWIPLL	DENND5B	1211	Q6ZUT9
ILRPSNGIWIKLKRR	CYP4V2	506	Q6ZWL3
RIFIAQPAWVLRKPR	DNAJC13	1986	O75165
QPAWVLRKPREFLIA	DNAJC13	1991	O75165
LLSLLPLVWKIPVQE	LYST	76	Q99698
PEGLLIVNTLPWKRI	MAN2C1	621	Q9NTJ4
TLRLSWDQPALLKRP	ITIH6	1171	Q6UXX5
VRQSPAWRILPAKIA	KNDC1	1596	Q76NI1
ITKNRLEWIVPLISP	CCDC168	3451	Q8NDH2
IVLLRQTQPPKGWLE	CAND2	401	O75155
LWRPGVKALLRIIEV	SEC14L1	406	Q92503
RLLILRAPRVFPVLW	SEC14L1	431	Q92503
WLLREFPEILPVDQK	METTL8	106	Q9H825
LSRKNDLIIWIRLVP	ERCC6L	361	Q2NKX8
KRVPNSVLWLLRFPA	OGT	866	O15294
IILVVLRIPSAKGRW	OR1Q1	221	Q15612
PIIVRWEKEDRIINP	DSCAM	816	O60469
IVLKEFRPEDQPWLL	GTF2F1	86	P35269
LRLTVWAPLLPLRIE	TMEM132A	486	Q24JP5
ARLSQVKGWRVPILP	TMEM132E	546	Q6IEE7
LLVLRLPWRVPGQLD	MIA3	11	Q5JRA6
LFPLPILEEKRWPQL	NHSL2	226	Q5HYW2
KWLIDPLPVNVRVIV	NPHP3	636	Q7Z494
WPLLRKQLEGRLALP	SPATA31A6	541	Q5VVP1
VWRIEKLELVPVPQS	SCIN	21	Q9Y6U3
FPLLEPKIQWRLQER	TAF1C	546	Q15572
PVEVPLWLAINLKQR	GINS2	41	Q9Y248
LQALLQIWPKLPPRE	PIK3CB	591	P42338
QIWPKLPPREALELL	PIK3CB	596	P42338
VDLWKTRLPELLQPL	MROH2B	546	Q7Z745
LFQTVWKRPLPVILG	SLC10A5	166	Q5PT55
LRPEKRPPVSVWVLQ	HTR7	441	P34969
KRNRLKLLLPWLEAR	CLTC	851	Q00610
PRPWITLKERDQILP	CNOT6L	171	Q96LI5
QTIPLKWLAPERLLL	STYK1	286	Q6J9G0
KWLAPERLLLRPASI	STYK1	291	Q6J9G0
PRPWPLLCRLLKEVV	RIPK3	111	Q9Y572
LLPIPLIVWVKRKEV	FAS	181	P25445
EALLALPVLRQPRAW	PKMYT1	351	Q99640
DRKLLRVLPLPSENW	UBE3D	121	Q7Z6J8
IGPWQPRIKKQLRVL	HEATR9	551	A2RTY3
RLARPRAGQKPWLLV	SCAND2P	271	Q9GZW5
QISVLDIPPFLWRIK	UNC5D	751	Q6UXZ4
RLRIPWLRGAKKVNI	ZDHHC23	76	Q8IYP9
TWILPKITRREPLEN	ERVK-19	451	Q9WJR5
VPPLRWKEFVRRLGL	TNFRSF1A	366	P19438
RLLRKLKGPVAPQEW	TFR2	366	Q9UP52
LWRLPPILIIHLKRF	USP32	1271	Q8NFA0
VWRLQRPLAEAPRSK	TYSND1	551	Q2T9J0
LWKAVADLLQPERPL	TSC2	81	P49815
QRKRELWPPEKLQEI	PET100	36	P0DJ07