Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

NPAS3 HOXA13 SHOX2 HOXB7 HOXC11 ZNF664 ZNF341 ESR1 NOTCH2 ZNF284

1.80e-0414123710GO:0000981
GeneOntologyBiologicalProcesscardiac chamber development

CITED2 HOXA13 SHOX2 BMP5 NSD2 NOTCH2

1.96e-06212376GO:0003205
GeneOntologyBiologicalProcesscardiac septum development

CITED2 HOXA13 BMP5 NSD2 NOTCH2

3.96e-06134375GO:0003279
GeneOntologyBiologicalProcessembryonic limb morphogenesis

HOXA13 SHOX2 HOXC11 DYNC2H1 NOTCH2

6.44e-06148375GO:0030326
GeneOntologyBiologicalProcessembryonic appendage morphogenesis

HOXA13 SHOX2 HOXC11 DYNC2H1 NOTCH2

6.44e-06148375GO:0035113
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

CITED2 SHOX2 BMP5 NSD2 NOTCH2

9.70e-06161375GO:0003206
GeneOntologyBiologicalProcessskeletal system development

CITED2 HOXA13 SHOX2 BMP5 HOXB7 HOXC11 NSD2 NOTCH2

1.07e-05615378GO:0001501
GeneOntologyBiologicalProcessappendage morphogenesis

HOXA13 SHOX2 HOXC11 DYNC2H1 NOTCH2

1.90e-05185375GO:0035107
GeneOntologyBiologicalProcesslimb morphogenesis

HOXA13 SHOX2 HOXC11 DYNC2H1 NOTCH2

1.90e-05185375GO:0035108
GeneOntologyBiologicalProcesscardiac septum morphogenesis

CITED2 BMP5 NSD2 NOTCH2

1.92e-0589374GO:0060411
GeneOntologyBiologicalProcessembryonic morphogenesis

CITED2 HOXA13 SHOX2 BMP5 HOXB7 HOXC11 DYNC2H1 NOTCH2

3.11e-05713378GO:0048598
GeneOntologyBiologicalProcesscardiac atrium morphogenesis

SHOX2 NSD2 NOTCH2

3.34e-0535373GO:0003209
GeneOntologyBiologicalProcesslimb development

HOXA13 SHOX2 HOXC11 DYNC2H1 NOTCH2

4.74e-05224375GO:0060173
GeneOntologyBiologicalProcessappendage development

HOXA13 SHOX2 HOXC11 DYNC2H1 NOTCH2

4.74e-05224375GO:0048736
GeneOntologyBiologicalProcessanimal organ morphogenesis

CITED2 HOXA13 SHOX2 BMP5 HOXB7 HOXC11 NSD2 ESR1 NOTCH2 MAPK8IP3

5.66e-0512693710GO:0009887
GeneOntologyBiologicalProcesscardiac atrium development

SHOX2 NSD2 NOTCH2

5.81e-0542373GO:0003230
GeneOntologyBiologicalProcessmorphogenesis of a branching structure

CITED2 HOXA13 SHOX2 HOXB7 ESR1

9.26e-05258375GO:0001763
GeneOntologyBiologicalProcessgenitalia development

HOXA13 BMP5 ESR1

1.24e-0454373GO:0048806
GeneOntologyBiologicalProcessregulation of morphogenesis of a branching structure

SHOX2 HOXB7 ESR1

2.15e-0465373GO:0060688
GeneOntologyBiologicalProcessembryonic skeletal joint morphogenesis

SHOX2 HOXC11

2.41e-0413372GO:0060272
GeneOntologyBiologicalProcessheart morphogenesis

CITED2 SHOX2 BMP5 NSD2 NOTCH2

2.56e-04321375GO:0003007
GeneOntologyBiologicalProcessleft/right axis specification

CITED2 NOTCH2

2.81e-0414372GO:0070986
GeneOntologyBiologicalProcessmaternal process involved in female pregnancy

CITED2 ADCY7 ESR1

3.03e-0473373GO:0060135
GeneOntologyBiologicalProcesspattern specification process

CITED2 BMP5 HOXB7 HOXC11 DYNC2H1 NOTCH2

3.17e-04526376GO:0007389
GeneOntologyBiologicalProcessbranching involved in prostate gland morphogenesis

HOXA13 ESR1

3.24e-0415372GO:0060442
GeneOntologyBiologicalProcesstissue morphogenesis

CITED2 HOXA13 SHOX2 BMP5 HOXB7 ESR1 NOTCH2

3.24e-04750377GO:0048729
GeneOntologyBiologicalProcessheart development

CITED2 HOXA13 SHOX2 BMP5 DYNC2H1 NSD2 NOTCH2

3.43e-04757377GO:0007507
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

CITED2 HOXA13 BMP5 GDF15 NOTCH2

3.67e-04347375GO:0090092
GeneOntologyBiologicalProcesspositive regulation of intracellular signal transduction

CITED2 SELP NMUR1 BMP5 GDF15 ESR1 NOTCH2 MAPK8IP3 BAG4

3.78e-041299379GO:1902533
GeneOntologyBiologicalProcessembryonic organ morphogenesis

CITED2 SHOX2 HOXB7 HOXC11 NOTCH2

3.86e-04351375GO:0048562
GeneOntologyBiologicalProcessembryonic skeletal joint development

SHOX2 HOXC11

4.19e-0417372GO:0072498
GeneOntologyBiologicalProcessmale sex differentiation

CITED2 HOXA13 BMP5 ESR1

4.33e-04199374GO:0046661
GeneOntologyBiologicalProcessembryonic organ development

CITED2 SHOX2 BMP5 HOXB7 HOXC11 NOTCH2

4.47e-04561376GO:0048568
GeneOntologyBiologicalProcessatrial septum morphogenesis

NSD2 NOTCH2

4.70e-0418372GO:0060413
GeneOntologyBiologicalProcesskidney development

CITED2 HOXB7 HOXC11 DYNC2H1 NOTCH2

5.04e-04372375GO:0001822
GeneOntologyBiologicalProcessventricular septum development

CITED2 HOXA13 NSD2

5.79e-0491373GO:0003281
GeneOntologyBiologicalProcessrenal system development

CITED2 HOXB7 HOXC11 DYNC2H1 NOTCH2

5.96e-04386375GO:0072001
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

CITED2 HOXA13 BMP5 HOXB7 ESR1 NOTCH2

7.50e-04619376GO:0002009
GeneOntologyBiologicalProcessembryo development

CITED2 HOXA13 SHOX2 BMP5 HOXB7 HOXC11 DYNC2H1 NOTCH2 MAPK8IP3

7.89e-041437379GO:0009790
GeneOntologyBiologicalProcessmorphogenesis of a branching epithelium

CITED2 HOXA13 HOXB7 ESR1

8.20e-04236374GO:0061138
GeneOntologyBiologicalProcessregulation of miRNA metabolic process

DROSHA ESR1 NOTCH2

8.31e-04103373GO:2000628
GeneOntologyBiologicalProcessepithelial tube morphogenesis

CITED2 BMP5 HOXB7 ESR1 NOTCH2

8.80e-04421375GO:0060562
GeneOntologyBiologicalProcessatrial septum development

NSD2 NOTCH2

9.15e-0425372GO:0003283
GeneOntologyBiologicalProcessembryonic skeletal system morphogenesis

SHOX2 HOXB7 HOXC11

9.79e-04109373GO:0048704
GeneOntologyBiologicalProcessmale genitalia development

HOXA13 BMP5

9.90e-0426372GO:0030539
GeneOntologyBiologicalProcesschordate embryonic development

CITED2 SHOX2 BMP5 HOXB7 HOXC11 NOTCH2 MAPK8IP3

1.00e-03906377GO:0043009
GeneOntologyBiologicalProcessfemale pregnancy

CITED2 CORIN ADCY7 ESR1

1.00e-03249374GO:0007565
GeneOntologyBiologicalProcessregulation of animal organ morphogenesis

CITED2 HOXB7 HOXC11

1.00e-03110373GO:2000027
GeneOntologyBiologicalProcessnephron tubule development

CITED2 HOXB7 NOTCH2

1.00e-03110373GO:0072080
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

CITED2 HOXA13 BMP5 GDF15 NOTCH2

1.13e-03445375GO:0141091
GeneOntologyBiologicalProcesspositive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

CITED2 BMP5 NOTCH2

1.14e-03115373GO:0090100
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

CITED2 SHOX2 BMP5 HOXB7 HOXC11 NOTCH2 MAPK8IP3

1.16e-03929377GO:0009792
GeneOntologyBiologicalProcessrenal tubule development

CITED2 HOXB7 NOTCH2

1.17e-03116373GO:0061326
GeneOntologyBiologicalProcessbone development

CITED2 SHOX2 NSD2 NOTCH2

1.24e-03264374GO:0060348
GeneOntologyBiologicalProcessmiRNA metabolic process

DROSHA ESR1 NOTCH2

1.26e-03119373GO:0010586
GeneOntologyBiologicalProcessuterus development

CITED2 ESR1

1.32e-0330372GO:0060065
GeneOntologyBiologicalProcessepithelial cell development

HOXA13 BMP5 ESR1 NOTCH2

1.33e-03269374GO:0002064
GeneOntologyBiologicalProcessskeletal system morphogenesis

CITED2 SHOX2 HOXB7 HOXC11

1.48e-03277374GO:0048705
GeneOntologyBiologicalProcessregulation of animal organ formation

CITED2 HOXC11

1.50e-0332372GO:0003156
GeneOntologyBiologicalProcessregionalization

CITED2 HOXB7 HOXC11 DYNC2H1 NOTCH2

1.55e-03478375GO:0003002
GeneOntologyBiologicalProcessnephron epithelium development

CITED2 HOXB7 NOTCH2

1.55e-03128373GO:0072009
GeneOntologyBiologicalProcessprostate gland epithelium morphogenesis

HOXA13 ESR1

1.60e-0333372GO:0060740
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

CITED2 HOXA13 BMP5 GDF15 NOTCH2

1.61e-03482375GO:0007178
GeneOntologyBiologicalProcessprostate gland morphogenesis

HOXA13 ESR1

1.69e-0334372GO:0060512
GeneOntologyBiologicalProcessmulti-organism reproductive process

CITED2 CORIN ADCY7 ESR1

1.75e-03290374GO:0044703
GeneOntologyBiologicalProcessmulti-multicellular organism process

CITED2 CORIN ADCY7 ESR1

1.84e-03294374GO:0044706
GeneOntologyBiologicalProcessembryonic forelimb morphogenesis

HOXA13 SHOX2

2.00e-0337372GO:0035115
GeneOntologyBiologicalProcesscardiac conduction system development

SHOX2 NOTCH2

2.34e-0340372GO:0003161
GeneOntologyBiologicalProcessembryonic skeletal system development

SHOX2 HOXB7 HOXC11

2.35e-03148373GO:0048706
DomainHomeobox_CS

HOXA13 SHOX2 HOXB7 HOXC11

4.37e-04186364IPR017970
DomainHomeobox

HOXA13 SHOX2 HOXB7 HOXC11

1.03e-03234364PF00046
DomainHOMEOBOX_1

HOXA13 SHOX2 HOXB7 HOXC11

1.07e-03236364PS00027
DomainHOX

HOXA13 SHOX2 HOXB7 HOXC11

1.08e-03237364SM00389
DomainHomeobox_dom

HOXA13 SHOX2 HOXB7 HOXC11

1.12e-03239364IPR001356
DomainHOMEOBOX_2

HOXA13 SHOX2 HOXB7 HOXC11

1.12e-03239364PS50071
DomainTGF-beta-rel

BMP5 GDF15

1.73e-0332362IPR015615
Domain-

HOXA13 SHOX2 HOXB7 HOXC11

2.08e-032833641.10.10.60
DomainTGFB

BMP5 GDF15

2.31e-0337362SM00204
DomainTGF_BETA_2

BMP5 GDF15

2.31e-0337362PS51362
DomainTGF_beta

BMP5 GDF15

2.31e-0337362PF00019
DomainTGF-b_C

BMP5 GDF15

2.31e-0337362IPR001839
DomainTGF_BETA_1

BMP5 GDF15

2.31e-0337362PS00250
DomainHomeodomain-like

HOXA13 SHOX2 HOXB7 HOXC11

3.69e-03332364IPR009057
DomainSushi

SELP C1R

4.51e-0352362PF00084
DomainCCP

SELP C1R

4.85e-0354362SM00032
DomainSUSHI

SELP C1R

5.21e-0356362PS50923
DomainSushi_SCR_CCP_dom

SELP C1R

5.39e-0357362IPR000436
Domain-

BMP5 GDF15

7.38e-03673622.10.90.10
DomainCystine-knot_cytokine

BMP5 GDF15

7.38e-0367362IPR029034
DomainGPCR_Rhodpsn_7TM

OR3A2 GPR135 OR3A3 NMUR1 GPR21

8.78e-03670365IPR017452
Domain7tm_1

OR3A2 GPR135 OR3A3 NMUR1 GPR21

9.17e-03677365PF00001
DomainG_PROTEIN_RECEP_F1_1

OR3A2 GPR135 OR3A3 NMUR1 GPR21

9.61e-03685365PS00237
DomainG_PROTEIN_RECEP_F1_2

OR3A2 GPR135 OR3A3 NMUR1 GPR21

9.96e-03691365PS50262
DomainGPCR_Rhodpsn

OR3A2 GPR135 OR3A3 NMUR1 GPR21

1.00e-02692365IPR000276
DomainEGF_3

SELP C1R NOTCH2

1.03e-02235363PS50026
DomainEGF

SELP C1R NOTCH2

1.03e-02235363SM00181
Pubmed

Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice.

GDF15 ESR1

1.10e-06237231304450
Pubmed

Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.

HOXA13 HOXB7 HOXC11

1.68e-062237326283362
Pubmed

Fine mapping of human HOX gene clusters.

HOXA13 HOXB7 HOXC11

2.83e-06263738646877
Pubmed

HOXB7 Is an ERα Cofactor in the Activation of HER2 and Multiple ER Target Genes Leading to Endocrine Resistance.

HOXB7 ESR1

3.30e-06337226180042
Pubmed

Correlation between genetic variations in Hox clusters and Hirschsprung's disease.

HOXA13 HOXB7

3.30e-06337217274802
Pubmed

Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.

DROSHA ESR1

3.30e-06337227380242
Pubmed

The human HOX gene family.

HOXA13 HOXB7 HOXC11

3.97e-06293732574852
Pubmed

A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.

HOXA13 HOXB7 HOXC11 ESR1

7.63e-0611837416971476
Pubmed

Complete mutation analysis panel of the 39 human HOX genes.

HOXA13 HOXB7 HOXC11

9.11e-063837311857506
Pubmed

Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.

HOXA13 HOXB7 HOXC11

9.86e-063937333257809
Pubmed

Quantification of Hox and surfactant protein-B transcription during murine lung development.

HOXA13 HOXB7 HOXC11

1.07e-054037319204410
Pubmed

Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.

CITED2 ESR1

1.10e-05537211581164
Pubmed

Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.

HOXA13 HOXB7 HOXC11

1.15e-054137332479258
Pubmed

Reduction of Hox gene expression by histone H1 depletion.

HOXA13 HOXB7 HOXC11

1.33e-054337322701719
Pubmed

Nomenclature for human homeobox genes.

HOXA13 HOXB7 HOXC11

1.42e-05443731973146
Pubmed

Vertebrate homeobox gene nomenclature.

HOXA13 HOXB7 HOXC11

1.74e-05473731358459
Pubmed

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.

HOXA13 HOXB7 HOXC11

2.10e-055037328188179
Pubmed

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.

NSD2 ESR1

2.30e-05737224101509
Pubmed

Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth.

HOXA13 SHOX2

2.30e-05737220043900
Pubmed

Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model.

HOXA13 HOXC11

3.07e-05837226238020
Pubmed

Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies.

HOXA13 ESR1

3.07e-05837226598695
Pubmed

Systematic identification of molecular links between core and candidate genes in breast cancer.

ESR1 NOTCH2 MAPK8IP3 BAG4

5.37e-0519437425640309
Pubmed

Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud.

HOXB7 HOXC11

6.02e-051137214597572
Pubmed

Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

OR3A2 OR3A3

6.02e-05113728004088
Pubmed

Homeobox genes: a link between development, cell cycle, and cancer?

HOXB7 HOXC11

6.02e-051137210328847
Pubmed

Tbx4 function during hindlimb development reveals a mechanism that explains the origins of proximal limb defects.

HOXA13 SHOX2

7.22e-051237234423345
Pubmed

A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.

GDF15 NOTCH2

8.53e-051337232929274
Pubmed

Multifaceted Hoxa13 function in urogenital development underlies the Hand-Foot-Genital Syndrome.

HOXA13 HOXB7

8.53e-051337230649340
Pubmed

The mouse Ulnaless mutation deregulates posterior HoxD gene expression and alters appendicular patterning.

HOXA13 HOXC11

9.94e-05143729342041
Pubmed

Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13.

HOXA13 HOXC11

1.31e-041637227974206
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR3A2 OR3A3

1.31e-041637210673334
Pubmed

Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia.

HOXA13 SHOX2

1.48e-041737215944189
Pubmed

Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling.

ESR1 NOTCH2

1.86e-041937229885287
Pubmed

Shox2 regulates progression through chondrogenesis in the mouse proximal limb.

HOXA13 SHOX2

1.86e-041937223038774
Pubmed

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

ATP4B NOTCH2

2.51e-042237221750033
Pubmed

The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.

ESR1 NOTCH2

2.75e-042337225505333
Pubmed

Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.

HOXA13 HOXB7

2.75e-042337228041967
Pubmed

Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development.

SHOX2 CORIN

2.75e-042337233898467
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

ESR1 NOTCH2

2.75e-042337236239412
Pubmed

A census of human transcription factors: function, expression and evolution.

NPAS3 HOXA13 SHOX2 HOXC11 NSD2 ESR1

3.63e-0490837619274049
Pubmed

Distribution of olfactory receptor genes in the human genome.

OR3A2 OR3A3

4.09e-04283729500546
Pubmed

EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

ESR1 NOTCH2

4.39e-042937224909139
Pubmed

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.

ESR1 NOTCH2

4.39e-042937224971735
Pubmed

Notch signaling in stomach epithelial stem cell homeostasis.

ATP4B NOTCH2

4.39e-042937221402740
Pubmed

DNA-binding specificities of human transcription factors.

HOXA13 SHOX2

5.02e-043137223332764
Pubmed

Forkhead box a2 (FOXA2) is essential for uterine function and fertility.

CITED2 ESR1

5.69e-043337228049832
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

HOXA13 SHOX2 ESR1 NOTCH2

7.17e-0438337419453261
Pubmed

Atlas of Hox gene expression in the developing kidney.

HOXB7 HOXC11

7.56e-043837215042701
Pubmed

Identification of 10 murine homeobox genes.

HOXB7 HOXC11

7.56e-04383721683707
Pubmed

FGF10 signaling controls stomach morphogenesis.

ATP4B NOTCH2

7.56e-043837217196193
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

CITED2 NPAS3 HOXA13 HOXB7 ESR1

8.82e-0470937522988430
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZNF341 NSD2 ADCY7 NISCH NOTCH2 MAPK8IP3

1.02e-03110537635748872
Cytoband2q37.1

NMUR1 MROH2A

1.35e-03673722q37.1
Cytoband17p13.3

OR3A2 OR3A3

2.32e-038837217p13.3
GeneFamilyOlfactory receptors, family 3

OR3A2 OR3A3

3.71e-056292150
GeneFamilyHOXL subclass homeoboxes

HOXA13 HOXB7 HOXC11

7.78e-0552293518
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SELP C1R

3.75e-03572921179
GeneFamilyG protein-coupled receptors, Class A orphans

GPR135 GPR21

6.92e-0378292262
CoexpressionGSE43863_NAIVE_VS_MEMORY_TH1_CD4_TCELL_D150_LCMV_UP

KLHL29 BMP5 PIEZO2 GVINP1 ZNF341

6.68e-06189375M9722
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1R CORIN PIEZO2 METTL24 ESR1

5.52e-07194375ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1R CORIN PIEZO2 METTL24 ESR1

5.52e-07194375240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SELP NMUR1 PIEZO2 DROSHA

5.79e-061423747b6678a73d04feac12bbc909f2df478215511de0
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SELP NMUR1 PIEZO2 DROSHA

5.79e-06142374347f5832a86f4e41752e36e3e737df7ca6f79e90
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 METTL24 ESR1

1.90e-051923744022f208eb5db760abd0aac782a25e8ab63efc64
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 METTL24 ESR1

1.90e-051923749093a9e94a25682d109a7f6edc256a25a61103a0
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KLHL29 C1R PIEZO2 ESR1

1.90e-051923748d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 METTL24 ESR1

1.90e-051923749ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SHOX2 BMP5 PIEZO2 METTL24

1.94e-05193374e5016959f24370579a8770787e96869f264cf7b3
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

C1R DYNC2H1 ESR1 NOTCH2

2.02e-05195374f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 METTL24 ESR1

2.10e-05197374b349f8e96d61a4c296af64711e11fc44459a9413
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 METTL24 ESR1

2.10e-051973746d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 METTL24 ESR1

2.10e-05197374c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SHOX2 BMP5 HOXB7 ESR1

2.14e-051983747d2fe57e0f9311ac1e6854402ebc154306eb1ba5
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPAS3 C1R BMP5 DYNC2H1

2.19e-05199374abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCellTracheal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPAS3 CORIN BMP5 PIEZO2

2.23e-05200374b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCellTracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPAS3 CORIN BMP5 PIEZO2

2.23e-05200374f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCellBiopsy_IPF-Mesenchymal-Myofibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

C1R CORIN BMP5 PIEZO2

2.23e-05200374c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

SELP GVINP1 ESR1

4.50e-05833733aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

SELP GVINP1 ESR1

4.50e-058337370804dd63221dd5ed26068ec1b50f11875abbc50
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SELP GVINP1 ESR1

4.50e-0583373c1818411438f53aec76afead5c8caab701b95d39
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

SELP GVINP1 ESR1

4.50e-05833731e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

C4orf51 ADCY7 ESR1

1.13e-04113373feb3c6a7723263d58e5ce020a0097fedfcf78ca8
ToppCellMild-Myeloid-Macrophages-|Mild / Condition, Lineage, Cell class and cell subclass

KLHL29 NMUR1 MAPK8IP3

1.41e-04122373b837456a6a236add2c0005cb3ca71568d631014e
ToppCellLPS_only-Endothelial-Epi-like|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CITED2 CORIN GDF15

1.55e-041263734c598f7bae09aca7a4ecce63dfd6890b26468c73
ToppCellLPS_only-Endothelial-Epi-like-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CITED2 CORIN GDF15

1.55e-04126373e065304f480a5e38532b66508b0ee87cc48bba9b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPAS3 ADCY7 ESR1

1.74e-041313733cb4b272e28ee9bad6d874f64a7aae18352a6cfb
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 NSD2 ESR1

1.78e-041323734152529611eeacf0c547e2a134d5b98c45426b13
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PADI4 NOTCH2 MAPK8IP3

3.31e-04163373abec4389cd88252449f110fe95416d67424b403a
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPR135 HOXA13 NISCH

3.49e-04166373eb9c81fa7573de7aff6670e7dad313f02129809f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HOXB7 NSD2 ADCY7

3.56e-041673733b717d33aaf1ef0869cc4bca8432ba8008875cc5
ToppCellfacs-Trachea-nan-18m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 ZNF341 ATP4B

3.56e-041673737b1fd19946cee67dae68f0f0d98420abcd532482
ToppCellBronchial_Brush-Epithelial-Goblet_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SELP HOXB7 ADCY7

3.56e-04167373806d1c00c137da0c5f042adf866873eb6dd4bb27
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NMUR1 HOXB7 METTL24

3.68e-04169373a3234904d7ff8f451ca894e93badd61d75e3cd2a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CITED2 NPAS3 ESR1

4.01e-04174373a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHOX2 CORIN GDF15

4.15e-041763734ed73c73972334f6dc4229920205547823252fa0
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NPAS3 C1R PIEZO2

4.22e-04177373bd602db857f37869ef76d14c05ef522c509f08ee
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP NPAS3 HOXB7

4.22e-04177373d68132e145bd413404fdbe215b5dbe520e756e50
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 PIEZO2 ESR1

4.29e-0417837378a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

BMP5 PIEZO2 NOTCH2

4.29e-04178373cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCellTCGA-Liver-Solid_Tissue_Normal|TCGA-Liver / Sample_Type by Project: Shred V9

C1R BMP5 ESR1

4.36e-041793737046f0a426e45fe1b41a25721ee1e33f6fc7f9e3
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver|TCGA-Liver / Sample_Type by Project: Shred V9

C1R BMP5 ESR1

4.36e-041793730e22e840f43ca81a7543dcf33ec17a741cdf7f37
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue|TCGA-Liver / Sample_Type by Project: Shred V9

C1R BMP5 ESR1

4.36e-0417937317ba1eedb6ebf039d3b11d099351d0ac6363c8d1
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP5 PIEZO2 DYNC2H1

4.36e-04179373a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue-2|TCGA-Liver / Sample_Type by Project: Shred V9

C1R BMP5 ESR1

4.36e-04179373a20bb3ace5be10c5aef330e9268c0ba55f8fee23
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP CORIN GPR21

4.43e-0418037367c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPAS3 BMP5 PIEZO2

4.43e-0418037308ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPAS3 BMP5 PIEZO2

4.43e-041803739b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPAS3 BMP5 PIEZO2

4.50e-041813739e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

C1R CORIN PIEZO2

4.50e-04181373bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

CITED2 KLHL29 CORIN

4.57e-04182373a035d45fd512bee8dac38eb387dbf39f5a8a1fed
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 BMP5 PIEZO2

4.79e-0418537340e958511790e84321da5ccf735f9974c06a0263
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 BMP5 PIEZO2

4.79e-041853735f2eeba80aff145e85cfd81e2890a155406badb9
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 BMP5 PIEZO2

4.79e-04185373f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1R BMP5 PIEZO2

4.79e-0418537387c416d14ca6255bee39b16e7571553e36ee3069
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NPAS3 HOXB7 HOXC11

4.87e-04186373bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CITED2 C1R BMP5

4.87e-04186373d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1R BMP5 PIEZO2

4.87e-041863735473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1R CORIN BMP5

4.95e-041873736f47a80e612b320f571210483e62ff5db2a8ea43
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

BMP5 HOXC11 DYNC2H1

5.02e-04188373116ca07ee4413dcc0e9e5ac99bfee6ed7b7847c6
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

NPAS3 BMP5 PIEZO2

5.02e-041883737b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NPAS3 GDF15 ADCY7

5.02e-041883733cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CORIN HOXB7 GDF15

5.02e-04188373c300accbac71a3bc075fe985543d8a8ead82531b
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BMP5 PIEZO2 DYNC2H1

5.10e-04189373203c80030df08ae112f9ae4043709f455d87ce89
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C1R BMP5 PIEZO2

5.10e-04189373e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BMP5 HOXB7 NOTCH2

5.10e-041893733169476f98b7385706cb618c9ad64ae83a290ef0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1R METTL24 ESR1

5.10e-04189373c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 ESR1

5.18e-041903731f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

CITED2 BMP5 PIEZO2

5.18e-0419037371e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D175|Adult / Lineage, Cell type, age group and donor

C1R PIEZO2 ESR1

5.18e-041903737dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 ESR1

5.18e-041903732306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KLHL29 SHOX2 BMP5

5.18e-0419037381f8f2cddf4c51b879f315260cd1fca80355a371
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CITED2 NPAS3 BMP5

5.18e-041903737986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1R METTL24 ESR1

5.18e-04190373445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KLHL29 SHOX2 BMP5

5.18e-04190373877b544decf302e0d41be23dffa1861f79c70914
ToppCell10x5'v1-week_17-19-Mesenchymal_myocytic-stroma-muscle|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KLHL29 SHOX2 BMP5

5.18e-0419037320106e5213f6a7560554b8b4f84b23c5554ba975
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1R METTL24 ESR1

5.18e-041903732e592323085ba9c019d678ac2a784462ab470ed9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R PIEZO2 ESR1

5.26e-04191373a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CITED2 NPAS3 PIEZO2

5.26e-04191373fa380a8752de158974b2ae5e741573439719cc0d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 METTL24 ESR1

5.26e-041913731caf726bd07fdca389e678fc16304a6ef1790423
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 METTL24 ESR1

5.26e-041913733d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1R METTL24 ESR1

5.26e-04191373806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

C1R BMP5 ESR1

5.34e-041923735105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BMP5 PIEZO2 ESR1

5.34e-04192373d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

C1R PIEZO2 ESR1

5.34e-04192373e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 METTL24 ESR1

5.34e-041923739333aba0d04203ccccad78d82bf6359922f810a7
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CITED2 BMP5 NISCH

5.34e-041923730afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C1R BMP5 PIEZO2

5.34e-04192373f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

C1R PIEZO2 ESR1

5.34e-04192373a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 NSD2 MROH2A

5.34e-041923731ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1R BMP5 PIEZO2

5.42e-04193373b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

C1R PIEZO2 ESR1

5.42e-041933739ab47b360bee1d4f1092c2269e58acebe9584021
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

NPAS3 C1R DYNC2H1

5.42e-04193373dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KLHL29 C1R ESR1

5.42e-04193373adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

KLHL29 C1R NOTCH2

5.51e-04194373d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCelldroplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PADI4 PIEZO2 ZNF664

5.51e-04194373715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 METTL24 ESR1

5.51e-0419437390efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1R BMP5 ESR1

5.51e-04194373e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO2 METTL24 ESR1

5.51e-04194373df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C1R BMP5 PIEZO2

5.51e-0419437389b706af2b25991fc2707eb24f49ba6ff3ae01f7
Drug5182598; Down 200; 25uM; MCF7; HT_HG-U133A_EA

CITED2 BMP5 HOXB7 HOXC11 DYNC2H1 ESR1

5.67e-07189376976_DN
Drugsemustine; Up 200; 100uM; MCF7; HT_HG-U133A

KLHL29 GPR135 BMP5 GDF15 ESR1

1.49e-051943757487_UP
DrugOxybenzone [131-57-7]; Down 200; 17.6uM; MCF7; HT_HG-U133A

SHOX2 HOXC11 ESR1 NOTCH2 BAG4

1.60e-051973755410_DN
DrugAmiprilose hydrochloride [60414-06-4]; Down 200; 11.8uM; HL60; HT_HG-U133A

GPR135 SHOX2 PADI4 GDF15 MAPK8IP3

1.64e-051983753000_DN
DrugChloropyramine hydrochloride [6170-42-9]; Down 200; 12.2uM; HL60; HT_HG-U133A

GPR135 SHOX2 NMUR1 GDF15 MAPK8IP3

1.68e-051993753011_DN
DrugParomomycin sulfate [1263-89-4]; Down 200; 5.6uM; HL60; HT_HG-U133A

GPR135 NMUR1 PADI4 ESR1 BAG4

1.68e-051993753017_DN
Diseaseobesity (implicated_via_orthology)

NMUR1 BMP5 ATP4B ESR1 NOTCH2

6.15e-06215365DOID:9970 (implicated_via_orthology)
Diseaselean body mass

NPAS3 KLHL29 BMP5 ZNF664 ESR1

9.25e-05379365EFO_0004995
DiseaseFemale Urogenital Diseases

HOXA13 ESR1

2.19e-0418362C1720887
DiseaseMammary Carcinoma, Human

DYNC2H1 NSD2 ESR1 NISCH NOTCH2

4.18e-04525365C4704874
DiseaseMammary Neoplasms, Human

DYNC2H1 NSD2 ESR1 NISCH NOTCH2

4.18e-04525365C1257931
DiseaseMammary Neoplasms

DYNC2H1 NSD2 ESR1 NISCH NOTCH2

4.25e-04527365C1458155
DiseaseCerebral Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0750935
DiseaseIntracranial Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0750936
DiseasePilocytic Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0334583
DiseaseAstrocytoma

ESR1 NOTCH2

4.27e-0425362C0004114
DiseaseJuvenile Pilocytic Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0280783
DiseaseDiffuse Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0280785
DiseaseGrade I Astrocytoma

ESR1 NOTCH2

4.27e-0425362C1704230
DiseaseSubependymal Giant Cell Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0205768
DiseaseMixed oligoastrocytoma

ESR1 NOTCH2

4.27e-0425362C0547065
DiseaseChildhood Cerebral Astrocytoma

ESR1 NOTCH2

4.27e-0425362C0338070
DiseaseGemistocytic astrocytoma

ESR1 NOTCH2

4.62e-0426362C0334581
DiseaseProtoplasmic astrocytoma

ESR1 NOTCH2

4.62e-0426362C0334580
DiseaseFibrillary Astrocytoma

ESR1 NOTCH2

4.62e-0426362C0334582
Diseaseinflammatory biomarker measurement

NPAS3 PIEZO2

4.62e-0426362EFO_0004872
DiseaseBreast Carcinoma

DYNC2H1 NSD2 ESR1 NISCH NOTCH2

4.67e-04538365C0678222
DiseaseAnaplastic astrocytoma

ESR1 NOTCH2

4.98e-0427362C0334579
DiseaseNeoplasm of uncertain or unknown behavior of breast

ESR1 NOTCH2

1.15e-0341362C0496956
DiseaseBreast adenocarcinoma

ESR1 NOTCH2

1.15e-0341362C0858252
Diseasediastolic blood pressure, systolic blood pressure

GPR135 BMP5 PIEZO2 DYNC2H1 ESR1

1.25e-03670365EFO_0006335, EFO_0006336
DiseaseMale sterility

DROSHA ESR1

1.58e-0348362C0917731
DiseaseMale infertility

DROSHA ESR1

1.58e-0348362C0021364
DiseaseSubfertility, Male

DROSHA ESR1

1.58e-0348362C0848676
Diseasegeneralised epilepsy

KLHL29 PADI4

1.85e-0352362EFO_0005917

Protein segments in the cluster

PeptideGeneStartEntry
DQSMNRHNFPCSVHQ

BAG4

306

O95429
DMRATCPAFNGNRTN

GVINP1

2111

Q7Z2Y8
HGDRRCMPDNNFHSL

ADCY7

256

P51828
ADMLQNCSGLADPNF

ATP4B

156

P51164
DVFSQNMFCAGHPSL

C1R

631

P00736
GDSCYPSNDSRQMHQ

PADI4

431

Q9UM07
ADANAQDNMGRCPLH

NOTCH2

1901

Q04721
QDNMGRCPLHAAVAA

NOTCH2

1906

Q04721
AGFSQRRNHAMCPIS

MAPK8IP3

606

Q9UPT6
RNPMACNGSAARGHF

NMUR1

21

Q9HB89
RSIQGHNDYMCPATN

ESR1

211

P03372
AMSTLNFCGPNEVNH

OR3A2

171

P47893
AMSTLNFCGPNEVNH

OR3A3

171

P47888
GPKGNYSRFMNHSCQ

NSD2

1131

O96028
IGACPSQFRAANMHA

GDF15

241

Q99988
EPSSFNMHCAPFEQN

HOXB7

81

P09629
NSNFMINCESNPALH

DYNC2H1

2786

Q8NCM8
NRLGACNRMSSSNPA

GPR135

436

Q8IZ08
SLPGDQSHRNTSACM

CORIN

126

Q9Y5Q5
CSFPLNAHMNATNHA

BMP5

386

P22003
MFNSVNLGNFCSPSR

HOXC11

1

O43248
MNCSHPLGNFSFNSQ

SELP

211

P16109
MNSTLDGNQSSHPFC

GPR21

1

Q99679
MCSQFSFRAGQHEPE

C4orf51

61

C9J302
LMLHSQDPCSNAAQA

MROH2A

1521

A6NES4
VSMANNGCEVHRFDP

METTL24

196

Q5JXM2
FGMNPDHARNSLSNC

DROSHA

906

Q9NRR4
GALRMPFQQDSHCNV

SHOX2

226

O60902
MNCNDDGHSSSNPDS

NPAS3

511

Q8IXF0
AAAANQCRNLMAHPA

HOXA13

81

P31271
MNGTNQHFRDCNPKH

CITED2

146

Q99967
PAFMTHKREQCQGNA

ZNF341

66

Q9BYN7
KADFNPMPNRGTHNC

NISCH

921

Q9Y2I1
ICMNLDAASFSQHNP

PIEZO2

1261

Q9H5I5
GGFCNFMHLRPISQN

U2AF1L4

166

Q8WU68
GRGFSNSSNLCMHQR

ZNF664

121

Q8N3J9
SNSFGQRSALNSHCM

ZNF284

321

Q2VY69
IKAGPNMNHSRQFCS

KLHL29

801

Q96CT2