Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	CPEB2 CPEB3 CPEB4	7.88e-05	17	100	3	GO:0000900
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	CPEB2 GARNL3 DOCK11 ALS2 ARHGEF17 KRIT1 KIAA1755 AGAP7P AGAP4 AGAP6	2.29e-04	507	100	10	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	CPEB2 GARNL3 DOCK11 ALS2 ARHGEF17 KRIT1 KIAA1755 AGAP7P AGAP4 AGAP6	2.29e-04	507	100	10	GO:0030695
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic translation	CPEB2 CPEB3 CPEB4	1.22e-05	10	98	3	GO:2000766
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic translational elongation	CPEB2 CPEB3	2.23e-05	2	98	2	GO:1900248
GeneOntologyBiologicalProcess	regulation of cytoplasmic translational elongation	CPEB2 CPEB3	6.68e-05	3	98	2	GO:1900247
HumanPheno	Recurrent opportunistic infections	RAG2 JAK3 DCLRE1C	1.94e-05	10	29	3	HP:0005390
MousePheno	absent B cells	GON4L JAK3 DCLRE1C	4.97e-05	14	74	3	MP:0008071
MousePheno	absent Hassall's corpuscle	RAG2 JAK3	8.27e-05	3	74	2	MP:0009540
MousePheno	abnormal Hassall's corpuscle morphology	RAG2 JAK3	8.27e-05	3	74	2	MP:0009539
MousePheno	arrested B cell differentiation	RAG2 GON4L JAK3 DCLRE1C	9.98e-05	46	74	4	MP:0001802
Domain	CEBP_ZZ	CPEB2 CPEB3 CPEB4	5.58e-07	4	98	3	IPR032296
Domain	CEBP_ZZ	CPEB2 CPEB3 CPEB4	5.58e-07	4	98	3	PF16366
Domain	RRM_7	CPEB2 CPEB3 CPEB4	5.58e-07	4	98	3	PF16367
Domain	-	MON2 MROH5 CKAP5 ARMH1 HEATR1 TRRAP CTNND2	1.69e-04	222	98	7	1.25.10.10
Domain	PH_dom-like	DOCK11 ALS2 ARHGEF17 JAK3 MTMR4 AGAP7P AGAP4 AGAP6 FRMD5	4.03e-04	426	98	9	IPR011993
Domain	ARM-type_fold	MON2 DOCK11 MROH5 CKAP5 ARMH1 HEATR1 TRRAP CTNND2	4.13e-04	339	98	8	IPR016024
Domain	ArfGap	AGAP7P AGAP4 AGAP6	4.64e-04	29	98	3	SM00105
Domain	ArfGap	AGAP7P AGAP4 AGAP6	4.64e-04	29	98	3	PF01412
Domain	ARFGAP	AGAP7P AGAP4 AGAP6	4.64e-04	29	98	3	PS50115
Domain	ArfGAP	AGAP7P AGAP4 AGAP6	4.64e-04	29	98	3	IPR001164
Domain	ARM-like	MON2 MROH5 CKAP5 ARMH1 HEATR1 TRRAP CTNND2	5.51e-04	270	98	7	IPR011989
Domain	SWIM	ZSWIM2 ZSWIM1	5.63e-04	7	98	2	PF04434
Domain	Transglut_N	TGM5 TGM2	9.58e-04	9	98	2	PF00868
Domain	TRANSGLUTAMINASES	TGM5 TGM2	9.58e-04	9	98	2	PS00547
Domain	Transglutaminase_N	TGM5 TGM2	9.58e-04	9	98	2	IPR001102
Domain	Transglut_C	TGM5 TGM2	9.58e-04	9	98	2	PF00927
Domain	-	TGM5 TGM2	9.58e-04	9	98	2	3.90.260.10
Domain	Gln_gamma-glutamylTfrase_euk	TGM5 TGM2	9.58e-04	9	98	2	IPR023608
Domain	Transglutaminase_AS	TGM5 TGM2	9.58e-04	9	98	2	IPR013808
Domain	Znf_SWIM	ZSWIM2 ZSWIM1	9.58e-04	9	98	2	IPR007527
Domain	ZF_SWIM	ZSWIM2 ZSWIM1	9.58e-04	9	98	2	PS50966
Domain	Transglutaminase_C	TGM5 TGM2	1.19e-03	10	98	2	IPR008958
Domain	TGc	TGM5 TGM2	1.45e-03	11	98	2	SM00460
Domain	Transglut_core	TGM5 TGM2	1.45e-03	11	98	2	PF01841
Domain	Transglutaminase-like	TGM5 TGM2	1.45e-03	11	98	2	IPR002931
Domain	FERM_domain	KRIT1 JAK3 FRMD5	2.17e-03	49	98	3	IPR000299
Domain	FERM_1	KRIT1 JAK3 FRMD5	2.30e-03	50	98	3	PS00660
Domain	FERM_2	KRIT1 JAK3 FRMD5	2.30e-03	50	98	3	PS00661
Domain	FERM_3	KRIT1 JAK3 FRMD5	2.30e-03	50	98	3	PS50057
Domain	Band_41_domain	KRIT1 JAK3 FRMD5	2.30e-03	50	98	3	IPR019749
Domain	B41	KRIT1 JAK3 FRMD5	2.30e-03	50	98	3	SM00295
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH8	2.38e-03	14	98	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH8	2.38e-03	14	98	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH8	2.38e-03	14	98	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH8	2.38e-03	14	98	2	PF08393
Domain	MT	DNAH3 DNAH8	2.38e-03	14	98	2	PF12777
Domain	AAA_8	DNAH3 DNAH8	2.38e-03	14	98	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH3 DNAH8	2.38e-03	14	98	2	IPR011704
Domain	AAA_5	DNAH3 DNAH8	2.38e-03	14	98	2	PF07728
Domain	DHC_fam	DNAH3 DNAH8	2.74e-03	15	98	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DNAH8	2.74e-03	15	98	2	IPR004273
Domain	Dynein_heavy	DNAH3 DNAH8	2.74e-03	15	98	2	PF03028
Domain	ZZ	ZSWIM2 ZZEF1	3.95e-03	18	98	2	PF00569
Domain	ZF_ZZ_2	ZSWIM2 ZZEF1	3.95e-03	18	98	2	PS50135
Domain	ZF_ZZ_1	ZSWIM2 ZZEF1	3.95e-03	18	98	2	PS01357
Domain	Znf_ZZ	ZSWIM2 ZZEF1	4.40e-03	19	98	2	IPR000433
Domain	PRAME_family	PRAMEF22 PRAMEF18	4.40e-03	19	98	2	IPR026271
Domain	ZnF_ZZ	ZSWIM2 ZZEF1	4.40e-03	19	98	2	SM00291
Domain	-	DOCK11 ALS2 ARHGEF17 MTMR4 AGAP4 AGAP6 FRMD5	4.52e-03	391	98	7	2.30.29.30
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB3 CPEB4	2.38e-08	3	101	3	12672660
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 CKAP5 GON4L ALS2 ARHGEF17 MAP3K4 SETDB1 MAPKBP1 SPEN VPS13B AQR	3.05e-08	407	101	11	12693553
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB2 CPEB3 CPEB4	9.49e-08	4	101	3	30177570
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB2 CPEB3 CPEB4	9.49e-08	4	101	3	12871996
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB2 CPEB3 CPEB4	2.37e-07	5	101	3	20639532
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP7P AGAP4 AGAP6	1.97e-06	9	101	3	12640130
Pubmed	Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review.	RAG2 JAK3 DCLRE1C	1.97e-06	9	101	3	14726805
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP7P AGAP4 AGAP6	2.81e-06	10	101	3	20664521
Pubmed	Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.	CPEB2 CPEB3 CPEB4	2.81e-06	10	101	3	27810937
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP7P AGAP4 AGAP6	3.86e-06	11	101	3	15381706
Pubmed	Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country.	RAG2 JAK3 DCLRE1C	6.66e-06	13	101	3	19859091
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP7P AGAP4 AGAP6	6.66e-06	13	101	3	27713690
Pubmed	Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice.	RAG2 JAK3	8.35e-06	2	101	2	21331358
Pubmed	A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.	TRPA1 AKAP1	8.35e-06	2	101	2	28500286
Pubmed	The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice.	TRPA1 BDKRB1	8.35e-06	2	101	2	27823962
Pubmed	The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.	CPEB2 CPEB3	8.35e-06	2	101	2	32440535
Pubmed	The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation.	ID2 CPEB4	8.35e-06	2	101	2	38284484
Pubmed	CPEB3 suppresses gastric cancer progression by inhibiting ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies.	CPEB3 ADAR	8.35e-06	2	101	2	36068334
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP7P AGAP4 AGAP6	8.45e-06	14	101	3	22453919
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	CPEB2 CPEB3 CPEB4	1.88e-05	18	101	3	30111840
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CPEB2 CPEB3 IFIT5 HEATR1 ADAR SART1 EIF4ENIF1 CPEB4 AKAP1 SPEN AQR	2.34e-05	807	101	11	22681889
Pubmed	Human UBL5 protein interacts with coilin and meets the Cajal bodies.	SART1 COIL	2.50e-05	3	101	2	23726919
Pubmed	S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways.	TRPA1 S1PR3	2.50e-05	3	101	2	30082422
Pubmed	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	CPEB3 CPEB4	2.50e-05	3	101	2	17024188
Pubmed	[Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].	LDHA DNAH8	2.50e-05	3	101	2	20653129
Pubmed	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	CPEB3 CPEB4	2.50e-05	3	101	2	20937770
Pubmed	Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.	LDHA SETDB1	2.50e-05	3	101	2	38426579
Pubmed	Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.	RPS6KB1 ADAR	2.50e-05	3	101	2	27863387
Pubmed	Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.	TRPA1 CDK5R1	2.50e-05	3	101	2	29352128
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	2.50e-05	3	101	2	26398195
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	EIF4ENIF1 CPEB4 CTNND2 AGAP7P AGAP4 AGAP6	4.37e-05	218	101	6	33378226
Pubmed	TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.	RAG2 ID2	4.99e-05	4	101	2	26280998
Pubmed	Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.	RAG2 DCLRE1C	4.99e-05	4	101	2	19362533
Pubmed	Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance.	RAG2 JAK3	4.99e-05	4	101	2	32699230
Pubmed	Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.	RAG2 DCLRE1C	4.99e-05	4	101	2	24218622
Pubmed	Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma.	TGM2 OSMR	4.99e-05	4	101	2	23765377
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	CPEB2 PRAMEF22 PRAMEF18 ADAR CPEB4 AKAP1 SPEN	7.14e-05	347	101	7	16033648
Pubmed	Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.	CPEB3 CPEB4	8.30e-05	5	101	2	21336257
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF22 PRAMEF18	8.30e-05	5	101	2	16159394
Pubmed	Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity.	RAG2 ID2	8.30e-05	5	101	2	35075279
Pubmed	Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility.	RAG2 JAK3	8.30e-05	5	101	2	9858510
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MON2 ZZEF1 TRRAP ARAF SART1 SETDB1 EIF4ENIF1 TIMM21 CPEB4 TMEM59L OSMR TCF7L1	9.70e-05	1116	101	12	31753913
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF22 PRAMEF18 EIF4ENIF1	1.11e-04	32	101	3	37889087
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RPS6KB1 GON4L ZZEF1 ARAF TGM2 TMEM62 DSTYK STARD3 AQR	1.19e-04	650	101	9	38777146
Pubmed	Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice.	TGM5 TGM2	1.24e-04	6	101	2	22258055
Pubmed	Bcl11b is essential for group 2 innate lymphoid cell development.	RAG2 ID2	1.24e-04	6	101	2	25964370
Pubmed	Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.	RAG2 DCLRE1C	1.24e-04	6	101	2	19450528
Pubmed	Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.	BDKRB1 F11	1.24e-04	6	101	2	27188843
Pubmed	The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor.	RAG2 ID2	1.24e-04	6	101	2	25310240
Pubmed	The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.	UBE2K SETDB1	1.24e-04	6	101	2	32451438
Pubmed	Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.	SART1 COIL	1.24e-04	6	101	2	16687569
Pubmed	Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.	RAG2 ID2	1.24e-04	6	101	2	25902484
Pubmed	Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.	TGM5 TGM2	1.74e-04	7	101	2	11390390
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH3 DNAH8	1.74e-04	7	101	2	9256245
Pubmed	Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.	CDK5R1 CTNND2	1.74e-04	7	101	2	20573893
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK11 CKAP5 ALS2 ARHGEF17 ARAF MTMR4 DSTYK AKAP1 AQR CCSER1	2.07e-04	861	101	10	36931259
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	CCDC73 TUBB8 ZZEF1 TRRAP DNAH8	2.22e-04	187	101	5	26460568
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CPEB4 ZFHX2 KIAA1755 CCSER1	2.29e-04	102	101	4	11214970
Pubmed	ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection.	RAG2 ID2	2.31e-04	8	101	2	35443177
Pubmed	HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.	TGM5 TGM2	2.31e-04	8	101	2	7906657
Pubmed	Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.	TGM5 TGM2	2.31e-04	8	101	2	7688299
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	ARAF SART1 TGM2 KCNA4 AGAP7P AGAP4 AGAP6	2.67e-04	430	101	7	32581705
Pubmed	ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.	RAG2 ID2	2.97e-04	9	101	2	28747424
Pubmed	Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling.	RAG2 ID2	2.97e-04	9	101	2	38723629
Pubmed	Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.	RAG2 ID2	2.97e-04	9	101	2	22972921
Pubmed	Genetic control of neuroadapted sindbis virus replication in female mice maps to chromosome 2 and associates with paralysis and mortality.	RAG2 KCNA4	3.70e-04	10	101	2	11507212
Pubmed	The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.	RPS6KB1 JAK3	3.70e-04	10	101	2	27742835
Pubmed	A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes.	TUBB8 TUBB8B	3.70e-04	10	101	2	11731935
Pubmed	Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1-/- (yotari) Mice.	UBE2K DSTYK	3.70e-04	10	101	2	35216141
Pubmed	Real-time resolution of point mutations that cause phenovariance in mice.	RAG2 JAK3	3.70e-04	10	101	2	25605905
Pubmed	Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.	UBE2K ADAR	4.51e-04	11	101	2	24882218
Pubmed	Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.	RAG2 JAK3	4.51e-04	11	101	2	23603794
Pubmed	The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.	RAG2 ID2	5.41e-04	12	101	2	18799150
Pubmed	Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.	RAG2 ID2	5.41e-04	12	101	2	20023630
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	GON4L ARHGEF17 ADAR SLC38A6 VPS13B	6.19e-04	234	101	5	36243803
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DOCK11 ETF1 TRRAP ARAF TGM5 MAP3K4 SART1	6.32e-04	497	101	7	36774506
Pubmed	Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.	TGM5 TMEM62	6.38e-04	13	101	2	12434312
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DNAH8	7.43e-04	14	101	2	9373155
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	TRPA1 MAOA PRAMEF22 PRAMEF18 TGM2 PLA2R1 ZFHX2 KIAA1755	7.94e-04	674	101	8	37196079
Pubmed	CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity.	RAG2 ID2	8.55e-04	15	101	2	25220211
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	CKAP5 IFIT5 HEATR1 LDHA EIF4ENIF1	9.26e-04	256	101	5	33397691
Pubmed	Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.	ID2 JAK3	9.76e-04	16	101	2	10687308
Pubmed	A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.	MAOA ARAF	1.10e-03	17	101	2	20808911
Pubmed	Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue.	JAK3 KCNA4	1.10e-03	17	101	2	10931824
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF22 PRAMEF18	1.10e-03	17	101	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF22 PRAMEF18	1.10e-03	17	101	2	37781892
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	TUBB8 CKAP5 TRRAP ADAR SART1	1.21e-03	272	101	5	31010829
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF22 PRAMEF18	1.24e-03	18	101	2	23894331
Pubmed	Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.	CKAP5 SPEN	1.24e-03	18	101	2	19640993
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF22 PRAMEF18	1.24e-03	18	101	2	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF22 PRAMEF18	1.24e-03	18	101	2	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF22 PRAMEF18	1.24e-03	18	101	2	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF22 PRAMEF18	1.24e-03	18	101	2	39181896
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	UBE2K TUBB8 PRAMEF22 PRAMEF18 LDHA BPNT1 TCF7L1	1.32e-03	564	101	7	21565611
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF22 PRAMEF18	1.38e-03	19	101	2	28604677
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CFAP47 DNAH3 CCDC73 DOCK11 CKAP5 ZZEF1 ARHGEF17 PLAAT3	1.39e-03	736	101	8	29676528
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	KCNA4 CTNND2 AGAP7P AGAP4 AGAP6	1.40e-03	281	101	5	28706196
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	IFIT5 ADAR SART1 COIL SPEN	1.44e-03	283	101	5	30585729
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF22 PRAMEF18	1.53e-03	20	101	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF22 PRAMEF18	1.53e-03	20	101	2	16580637
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	SYT15 SYT15B AGAP7P AGAP4 AGAP6	6.29e-05	188	101	5	chr10q11
Cytoband	2p24.2	RAD51AP2 CYRIA	2.13e-04	10	101	2	2p24.2
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	TGM5 TMEM62 MAPKBP1 FRMD5	3.24e-04	147	101	4	chr15q15
Cytoband	1p36.21	AADACL3 PRAMEF22 PRAMEF18	3.73e-04	63	101	3	1p36.21
Cytoband	7q21.2	KRIT1 LRRD1	4.94e-04	15	101	2	7q21.2
Cytoband	15q15.2	TGM5 TMEM62	5.64e-04	16	101	2	15q15.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2p24	RAD51AP2 NBAS CYRIA	7.78e-04	81	101	3	chr2p24
Cytoband	Ensembl 112 genes in cytogenetic band chr17q22	MTMR4 COIL AKAP1	9.90e-04	88	101	3	chr17q22
Cytoband	8q22.2	RGS22 VPS13B	1.18e-03	23	101	2	8q22.2
Cytoband	10q11.23	AGAP7P AGAP6	2.42e-03	33	101	2	10q11.23
Cytoband	16p12.3	DNAH3 IQCK	2.57e-03	34	101	2	16p12.3
Cytoband	20q11.23	CNBD2 KIAA1755	3.04e-03	37	101	2	20q11.23
Cytoband	17q22	COIL AKAP1	4.27e-03	44	101	2	17q22
GeneFamily	Phosphoinositide phosphatases	INPP4B BPNT1 MTMR4	1.77e-04	32	62	3	1079
GeneFamily	ArfGAPs	AGAP7P AGAP4 AGAP6	1.95e-04	33	62	3	395
GeneFamily	Transglutaminases	TGM5 TGM2	4.10e-04	9	62	2	773
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM2 ZSWIM1	4.10e-04	9	62	2	90
GeneFamily	Ankyrin repeat domain containing	TRPA1 KRIT1 AGAP7P AGAP4 AGAP6	1.43e-03	242	62	5	403
GeneFamily	Dyneins, axonemal	DNAH3 DNAH8	1.52e-03	17	62	2	536
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	1.52e-03	17	62	2	1291
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	ZSWIM2 ZZEF1	1.71e-03	18	62	2	91
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	ARAF MAP3K4	3.04e-03	24	62	2	654
GeneFamily	PRAME family	PRAMEF22 PRAMEF18	3.04e-03	24	62	2	686
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK11 AGAP7P AGAP4 AGAP6	5.45e-03	206	62	4	682
GeneFamily	RNA binding motif containing	CPEB2 CPEB3 CPEB4 SPEN	6.13e-03	213	62	4	725
GeneFamily	Tudor domain containing	SETDB1 AKAP1	7.13e-03	37	62	2	780
Disease	cerebral palsy (implicated_via_orthology)	AGAP7P AGAP4 AGAP6	4.06e-06	10	97	3	DOID:1969 (implicated_via_orthology)
Disease	severe combined immunodeficiency (is_implicated_in)	RAG2 JAK3 DCLRE1C	1.22e-05	14	97	3	DOID:627 (is_implicated_in)
Disease	OMENN SYNDROME	RAG2 DCLRE1C	3.20e-05	3	97	2	603554
Disease	Reticuloendotheliosis, familial, with eosinophilia	RAG2 DCLRE1C	3.20e-05	3	97	2	C2931884
Disease	Omenn syndrome (is_implicated_in)	RAG2 DCLRE1C	3.20e-05	3	97	2	DOID:0060010 (is_implicated_in)
Disease	overactive bladder syndrome (implicated_via_orthology)	TRPA1 BDKRB1	3.20e-05	3	97	2	DOID:0070355 (implicated_via_orthology)
Disease	Histiocytic medullary reticulosis	RAG2 DCLRE1C	3.20e-05	3	97	2	cv:C2700553
Disease	Omenn Syndrome	RAG2 JAK3 DCLRE1C	3.21e-05	19	97	3	C2700553
Disease	Severe Combined Immunodeficiency	RAG2 JAK3 DCLRE1C	3.77e-05	20	97	3	C0085110
Disease	level of oxylipin in blood plasma	TGM2 KIAA1755	2.22e-04	7	97	2	OBA_2050338
Disease	facial paralysis (implicated_via_orthology)	TUBB8 TUBB8B	4.73e-04	10	97	2	DOID:13934 (implicated_via_orthology)
Disease	complex cortical dysplasia with other brain malformations 7 (implicated_via_orthology)	TUBB8 TUBB8B	4.73e-04	10	97	2	DOID:0090132 (implicated_via_orthology)
Disease	ptosis (implicated_via_orthology)	TUBB8 TUBB8B	4.73e-04	10	97	2	DOID:0060260 (implicated_via_orthology)
Disease	tubulinopathy (implicated_via_orthology)	TUBB8 TUBB8B	4.73e-04	10	97	2	DOID:0112227 (implicated_via_orthology)
Disease	cerebellar ataxia, mental retardation and dysequlibrium syndrome (implicated_via_orthology)	TUBB8 TUBB8B	6.91e-04	12	97	2	DOID:0050997 (implicated_via_orthology)
Disease	diabetic neuropathy (implicated_via_orthology)	TRPA1 BDKRB1	9.49e-04	14	97	2	DOID:9743 (implicated_via_orthology)
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	CKAP5 F11	2.16e-03	21	97	2	EFO_0004286, EFO_0004792
Disease	Ovarian Serous Adenocarcinoma	TRRAP MAP3K4	2.59e-03	23	97	2	C1335177

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVVLITNPKSLLYSC	TMEM62	311	Q0P6H9
CEDSLPPYKLKLDLT	TMEM59L	326	Q9UK28
SKYEEKLFLAPLPCT	AGAP4	546	Q96P64
LYKQCTPKSLAPISS	BDKRB1	326	P46663
PPKTYVSCLKSLLSS	AKAP1	431	Q92667
ISYPLKPFLVESCKE	CDK5R1	241	Q15078
SKTPVLLSCSKLGYI	ALS2	656	Q96Q42
YNLKLKPCDGPVLIT	ACTRT3	91	Q9BYD9
VYKGLIALLPCESPK	ARMH1	186	Q6PIY5
ASYLCLLPTLPKNED	AQR	381	O60306
SPYKNKTCQLPSLCL	CCSER1	776	Q9C0I3
TIPVKLYQPKASTCT	AADACL3	96	Q5VUY0
LKQPCPSQYSAIKEE	BPNT1	96	O95861
IVKPYLTLLSECSNP	CTNND2	846	Q9UQB3
SKYEEKLFLAPLPCT	AGAP6	546	Q5VW22
TLTKPHPCVLLKLYS	CPNE6	36	O95741
LYSTSEKDCETPLPK	RAD51AP2	1076	Q09MP3
KLKPTIFSKDSCYLP	RAG2	56	P55895
CLLEKKTGYSQELAP	OSMR	611	Q99650
INPKTCSPKEYLETF	IQCK	121	Q8N0W5
KTVSYKACLPPSLRD	JAK3	186	P52333
KYSPNCKLLIVSNPV	LDHA	126	P00338
EKQALCYALSFPPTK	ARHGEF17	1421	Q96PE2
CKYVINAIPPTLTAK	MAOA	266	P21397
PPLIKLSCSDTYVKE	OR5M11	181	Q96RB7
KALQSLLESLTCPPY	CYRIA	101	Q9H0Q0
IPPLLKLACADTSRY	OR2AG2	181	A6NM03
QLTTFPKALCFLPKL	LRRD1	291	A4D1F6
LSYLCTIPRPEDKAK	KIAA1755	616	Q5JYT7
LKNPVCKLYRFPTSD	INPP4B	231	O15327
AINSTAPKDPKLYVC	DNAH8	4436	Q96JB1
KCLPRYPSLSQLKQL	PRAMEF18	311	Q5VWM3
TPKKDYSLLPLLAAA	COIL	456	P38432
KDCSINPKSPLLYVT	NDST1	196	P52848
LKCKLNLPPYLTQEA	RPS6KB1	306	P23443
CSENLSLQLKPYHKP	KRIT1	466	O00522
KTLRVPLSLKYSCPS	MON2	1441	Q7Z3U7
DAKLLVKCVSTPFYP	NBAS	2296	A2RRP1
LSCISFPPKEEKYLQ	DSTYK	91	Q6XUX3
KSCSPSYKLLNTAVP	MTMR4	696	Q9NYA4
SLEYSPSPISKKLSC	RETNLB	41	Q9BQ08
KKIILTYFAPTPEAC	FRMD5	266	Q7Z6J6
YLSPDLSKISSNCPK	ARAF	526	P10398
TLPKSLLKPFCAALL	CKAP5	431	Q14008
KLSSPSNYKLECPET	IFIT5	126	Q13325
CSPVTKELLLTSPKY	DCLRE1C	61	Q96SD1
ITSSYVPLKPFEKNC	DOCK11	601	Q5JSL3
KLYLCVSSPTIKDKP	CPEB2	401	Q7Z5Q1
SPYKKLTECQLKNPI	ADAR	491	P55265
LYLCVSSPTIKDKPV	CPEB3	511	Q8NE35
KFKQYIPILSISCNP	DNAH3	936	Q8TD57
SPTKYNLLELKESCI	CLPSL1	26	A2RUU4
SSLDIKKNPVPCQKY	CCDC73	631	Q6ZRK6
FPNPLISKYLLTCKT	GON4L	846	Q3T8J9
CYLKLSSNGSPTKIL	F11	346	P03951
SKYEEKLFLAPLPCT	AGAP7P	546	Q5VUJ5
CLEYSKPDTGLKLLA	MAPKBP1	526	O60336
KLYLCVSSPTIKDKP	CPEB4	541	Q17RY0
LSPYFLLKPAQKCLE	HEATR1	101	Q9H583
NLPDCSTILPLYSKK	S1PR3	181	Q99500
LSDSPSLCRPVYSKK	SLFN13	371	Q68D06
PLQSGRYPCKILLKS	CFAP47	2286	Q6ZTR5
ICLPYSPTKTLSVKS	GARNL3	151	Q5VVW2
SPCPKEKTYLRLLAA	MROH5	866	Q6ZUA9
KPYLSLGCSNAKLPV	MAP3K4	186	Q9Y6R4
APSETCSPLVKLYLL	SYT15	176	Q9BQS2
DDKYSPLPCSKIIQR	PLAAT3	81	P53816
PTKIYDKTEKPCLLS	SAXO1	21	Q8IYX7
CVPYNKLKSPAISSV	RGS22	226	Q8NE09
NYFPPKSLLKLLHSC	FASTKD3	441	Q14CZ7
KLLPKYQVKSFLTPC	FASTKD3	511	Q14CZ7
DCYSKLKELVPSIPQ	ID2	41	Q02363
DLKCLPRYPSLSQLK	PRAMEF22	311	A3QJZ6
ILPIYCELQSPSKKR	SLC38A6	266	Q8IZM9
KIQPCLSKPAFASLL	ST3GAL6	41	Q9Y274
PPLIKLACSDTYNKE	OR5M8	181	Q8NGP6
NYKCLLLNIPKDPSS	PLA2R1	966	Q13018
KTFILKTFLPCPAEL	STARD3	281	Q14849
TQSELYPICRPLKKT	SETDB1	306	Q15047
KLTYKDLLLSNSCIP	SEMA3D	46	O95025
LPHSKQRPSCLSEKY	EIF4ENIF1	41	Q9NRA8
IKSYPLQDFSSLKLP	CNBD2	336	Q96M20
PFSEKSVPLCILYEK	TGM2	536	P21980
KYLQCPLEFTKKTPT	TRPA1	661	O75762
QLKSESKCYDLAPAP	ZFHX2	2181	Q9C0A1
CSSLSPPRYEKLDKS	SPEN	766	Q96T58
ALYDICSKTLKLPTP	TUBB8	206	Q3ZCM7
ALASKSKKPCVQYLP	TCF7L1	446	Q9HCS4
SETCSPLVKLYLLPD	SYT15B	231	X6R8R1
ALYDICSRTLKLPTP	TUBB8B	206	A6NNZ2
CLSTLPSKIFPYNKC	ZNF682	136	O95780
TLSPKEAKTYPCKIS	TGM5	566	O43548
VKAPNKSLPSAVYCI	SART1	661	O43290
PYIVLNKACLKTEPS	TIMM21	26	Q9BVV7
ITKNSKLLAPGYQCL	ZSWIM2	331	Q8NEG5
PVSSPEYTKKIENLC	UBE2K	156	P61086
YPDCKTKDLLPSLLL	VPS13B	3301	Q7Z7G8
LLKYGKPLQLTLQAC	ZZEF1	521	O43149
RKLYTLLSNCIPPAK	ZSWIM1	211	Q9BR11
EDSALTKLPCYKSLP	TRRAP	1346	Q9Y4A5
PFKPINTSLYLCDNK	ETF1	116	P62495
CPYLPSNLLKKFRSS	KCNA4	586	P22459