Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	NRBP1 MINK1 MAST2 MELK GRK1 NRBP2 MAST4 PIK3CA CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 ENG PKN3 MAST3 DYRK3 DYRK2	6.52e-11	446	143	20	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRP1 NRBP2 MAST4 PIK3CA CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 ENG PKN3 MAST3 DYRK3 DYRK2	3.15e-10	600	143	22	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRP1 NRBP2 MAST4 PIK3CA CSNK1D CSNK1E PI4KB NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 ENG PKN3 MAST3 DYRK3 DYRK2	1.29e-09	709	143	23	GO:0016773
GeneOntologyMolecularFunction	kinase activity	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRP1 NRBP2 MAST4 PIK3CA CSNK1D CSNK1E PI4KB NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 ENG PKN3 MAST3 DYRK3 DYRK2	5.31e-09	764	143	23	GO:0016301
GeneOntologyMolecularFunction	protein serine kinase activity	MINK1 MAST2 MELK MAST4 PIK3CA CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	7.71e-09	363	143	16	GO:0106310
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRP1 NRBP2 MAST4 PIK3CA CSNK1D CSNK1E PI4KB NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 ENG PKN3 MAST3 DYRK3 DYRK2	2.25e-07	938	143	23	GO:0016772
GeneOntologyMolecularFunction	enzyme activator activity	DAB2IP DOCK1 TBC1D9B PREX2 MADD PPP4R3A NRP1 AZIN1 PIK3CA ARHGAP44 MAP2K1 MAP2K2 GCN1 PREX1 ARAP1 ARAP2	1.96e-05	656	143	16	GO:0008047
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	MAPKAPK3 MAP2K1 MAP2K2 DYRK3 DYRK2	2.11e-05	47	143	5	GO:0004712
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	5.09e-05	2	143	2	GO:0004478
GeneOntologyMolecularFunction	rRNA (cytosine-N4-)-methyltransferase activity	METTL15P1 METTL15	5.09e-05	2	143	2	GO:0071424
GeneOntologyMolecularFunction	magnesium ion binding	DIS3L2 MAT1A MAST2 FAN1 LIG4 MAST4 MAST3 DYRK3 DYRK2	7.41e-05	247	143	9	GO:0000287
GeneOntologyMolecularFunction	protein tyrosine kinase activity	MELK ITK NRP1 MAP2K1 MAP2K2 DYRK3 DYRK2	8.45e-05	145	143	7	GO:0004713
GeneOntologyMolecularFunction	GTPase activator activity	DAB2IP DOCK1 TBC1D9B PREX2 NRP1 ARHGAP44 PREX1 ARAP1 ARAP2	1.86e-04	279	143	9	GO:0005096
GeneOntologyMolecularFunction	MAP kinase kinase activity	MAPKAPK3 MAP2K1 MAP2K2	2.71e-04	18	143	3	GO:0004708
GeneOntologyMolecularFunction	enzyme regulator activity	DAB2IP DOCK1 TBC1D9B PSMD2 PREX2 MADD PPP4R3A NRP1 AZIN1 ARFGEF3 SERPINB13 PIK3CA ABCE1 ARHGAP44 PPME1 SERPINB1 MAP2K1 MAP2K2 GCN1 PREX1 ARAP1 ARAP2	4.76e-04	1418	143	22	GO:0030234
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	DAB2IP LAPTM4B ATG2B EXOC1 VPS13B ARAP1 ARAP2	5.86e-04	199	143	7	GO:1901981
GeneOntologyMolecularFunction	protein kinase activator activity	DAB2IP MADD PIK3CA MAP2K1 MAP2K2 GCN1	7.20e-04	149	143	6	GO:0030295
GeneOntologyMolecularFunction	death receptor binding	DAB2IP PRDM4 MADD	7.37e-04	25	143	3	GO:0005123
GeneOntologyMolecularFunction	rRNA (cytosine) methyltransferase activity	METTL15P1 METTL15	7.50e-04	6	143	2	GO:0016434
GeneOntologyMolecularFunction	kinase activator activity	DAB2IP MADD PIK3CA MAP2K1 MAP2K2 GCN1	1.01e-03	159	143	6	GO:0019209
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DAB2IP DOCK1 TBC1D9B PREX2 MADD NRP1 ARFGEF3 ARHGAP44 PREX1 ARAP1 ARAP2	1.08e-03	507	143	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DAB2IP DOCK1 TBC1D9B PREX2 MADD NRP1 ARFGEF3 ARHGAP44 PREX1 ARAP1 ARAP2	1.08e-03	507	143	11	GO:0030695
GeneOntologyMolecularFunction	microtubule motor activity	KIF1A DNAH17 KIF14 DNAH5	1.60e-03	70	143	4	GO:0003777
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF1A DNAH17 KIF14 MYO18B DNAH5	1.61e-03	118	143	5	GO:0003774
GeneOntologyBiologicalProcess	vesicle transport along microtubule	BLOC1S4 KIF1A HAP1 MADD MAP2K1	2.54e-05	51	141	5	GO:0047496
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	MAST2 MAST4 CSNK1D CSNK1E MAPKAPK3 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	5.11e-05	307	141	10	GO:0018105
GeneOntologyBiologicalProcess	organelle transport along microtubule	HIF1A BLOC1S4 KIF1A HAP1 MADD MAP2K1	5.44e-05	97	141	6	GO:0072384
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	ATMIN TBC1D9B HAP1 ODAD1 MINK1 RO60 ABLIM3 CDC14A NRP1 PIK3CA CSNK1D ARHGAP44 DNAH17 DNAH5 ARAP1	5.62e-05	670	141	15	GO:0120031
GeneOntologyBiologicalProcess	peptidyl-serine modification	MAST2 MAST4 CSNK1D CSNK1E MAPKAPK3 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	7.03e-05	319	141	10	GO:0018209
GeneOntologyBiologicalProcess	cell projection assembly	ATMIN TBC1D9B HAP1 ODAD1 MINK1 RO60 ABLIM3 CDC14A NRP1 PIK3CA CSNK1D ARHGAP44 DNAH17 DNAH5 ARAP1	7.21e-05	685	141	15	GO:0030031
GeneOntologyBiologicalProcess	vesicle cytoskeletal trafficking	BLOC1S4 KIF1A HAP1 MADD MAP2K1	9.55e-05	67	141	5	GO:0099518
GeneOntologyBiologicalProcess	amino acid metabolic process	RIMKLA MAT1A IARS1 PEPD DARS1 SLC7A7 LARS2 AZIN1 FAH NOS3	9.78e-05	332	141	10	GO:0006520
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	DAB2IP PREX2 MADD NRP1 ARFGEF3 ARHGAP44 KIF14 MAP2K1 PREX1 ARAP1	1.00e-04	333	141	10	GO:0051056
GeneOntologyBiologicalProcess	establishment of vesicle localization	BLOC1S4 KIF1A HAP1 MADD CSNK1D EXOC1 TBC1D23 MAP2K1	1.57e-04	224	141	8	GO:0051650
GeneOntologyBiologicalProcess	axonal transport	HIF1A BLOC1S4 KIF1A HAP1 MADD	1.63e-04	75	141	5	GO:0098930
GeneOntologyCellularComponent	outer dynein arm	ODAD1 DNAH17 DNAH5	6.59e-05	12	143	3	GO:0036157
GeneOntologyCellularComponent	axon cytoplasm	HIF1A BLOC1S4 KIF1A HAP1 MADD	1.03e-04	68	143	5	GO:1904115
GeneOntologyCellularComponent	neuron projection cytoplasm	HIF1A BLOC1S4 KIF1A HAP1 MADD MAP2K1	1.10e-04	110	143	6	GO:0120111
GeneOntologyCellularComponent	methionine adenosyltransferase complex	MAT1A MAT2A	1.39e-04	3	143	2	GO:0048269
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	HIF1A BLOC1S4 KIF1A HAP1 ODAD1 MADD DNAH17 MAP2K1 DNAH5	3.42e-04	317	143	9	GO:0032838
GeneOntologyCellularComponent	axonemal dynein complex	ODAD1 DNAH17 DNAH5	6.46e-04	25	143	3	GO:0005858
GeneOntologyCellularComponent	cytoplasmic region	HIF1A BLOC1S4 KIF1A HAP1 ODAD1 MADD DNAH17 MAP2K1 DNAH5	8.50e-04	360	143	9	GO:0099568
Domain	Pkinase	NRBP1 MINK1 MAST2 MELK GRK1 NRBP2 MAST4 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	6.22e-10	381	141	18	PF00069
Domain	Kinase-like_dom	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRBP2 MAST4 PIK3CA CSNK1D CSNK1E PI4KB NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	7.73e-10	542	141	21	IPR011009
Domain	Prot_kinase_dom	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRBP2 MAST4 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	5.11e-09	489	141	19	IPR000719
Domain	PROTEIN_KINASE_DOM	NRBP1 MINK1 MAST2 MELK ITK GRK1 NRBP2 MAST4 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	5.84e-09	493	141	19	PS50011
Domain	Ser/Thr_kinase_AS	MINK1 MAST2 MELK GRK1 MAST4 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	1.25e-08	357	141	16	IPR008271
Domain	PROTEIN_KINASE_ST	MINK1 MAST2 MELK GRK1 MAST4 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	1.53e-08	362	141	16	PS00108
Domain	PROTEIN_KINASE_ATP	MINK1 MAST2 MELK ITK GRK1 MAST4 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	6.99e-08	459	141	17	PS00107
Domain	S_TKc	MINK1 MAST2 MELK GRK1 MAST4 CSNK1D NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 MAST3 DYRK3 DYRK2	9.22e-08	359	141	15	SM00220
Domain	Protein_kinase_ATP_BS	MINK1 MELK ITK GRK1 CSNK1D CSNK1E NEK8 NRK MAPKAPK3 MAP2K1 MAP2K2 PKN3 DYRK3 DYRK2	1.11e-06	379	141	14	IPR017441
Domain	DUF1908	MAST2 MAST4 MAST3	1.68e-06	4	141	3	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST2 MAST4 MAST3	1.68e-06	4	141	3	IPR015022
Domain	MAST_pre-PK_dom	MAST2 MAST4 MAST3	1.68e-06	4	141	3	IPR023142
Domain	-	MAST2 MAST4 MAST3	1.68e-06	4	141	3	1.20.1480.20
Domain	S-AdoMet_synt_N	MAT1A MAT2A	5.66e-05	2	141	2	PF00438
Domain	S-AdoMet_synthetase	MAT1A MAT2A	5.66e-05	2	141	2	IPR002133
Domain	S-AdoMet_synt_M	MAT1A MAT2A	5.66e-05	2	141	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	5.66e-05	2	141	2	PF02773
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	5.66e-05	2	141	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	5.66e-05	2	141	2	IPR022630
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	5.66e-05	2	141	2	IPR022636
Domain	S-AdoMet_synt_central	MAT1A MAT2A	5.66e-05	2	141	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	5.66e-05	2	141	2	IPR022628
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	5.66e-05	2	141	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	5.66e-05	2	141	2	PS00377
Domain	AGC-kinase_C	MAST2 GRK1 MAST4 PKN3 MAST3	6.40e-05	56	141	5	IPR000961
Domain	AGC_KINASE_CTER	MAST2 GRK1 MAST4 PKN3 MAST3	6.40e-05	56	141	5	PS51285
Domain	S_TK_X	MAST2 GRK1 MAST4 PKN3 MAST3	6.40e-05	56	141	5	SM00133
Domain	DCN-prot	DCUN1D1 DCUN1D2	5.58e-04	5	141	2	IPR014764
Domain	PONY_dom	DCUN1D1 DCUN1D2	5.58e-04	5	141	2	IPR005176
Domain	DCUN1	DCUN1D1 DCUN1D2	5.58e-04	5	141	2	PS51229
Domain	Autophagy-rel_C	ATG2B VPS13B	5.58e-04	5	141	2	IPR015412
Domain	ATG_C	ATG2B VPS13B	5.58e-04	5	141	2	PF09333
Domain	Pept_S1A_HAT/DESC1	TMPRSS11F TMPRSS11B	5.58e-04	5	141	2	IPR017329
Domain	Cullin_binding	DCUN1D1 DCUN1D2	5.58e-04	5	141	2	PF03556
Domain	Kinesin_assoc	KIF1A KIF14	8.32e-04	6	141	2	PF16183
Domain	Val/Leu/Ile-tRNA-synth_edit	IARS1 LARS2	8.32e-04	6	141	2	IPR009008
Domain	Anticodon_1	IARS1 LARS2	8.32e-04	6	141	2	PF08264
Domain	Kinesin_assoc	KIF1A KIF14	8.32e-04	6	141	2	IPR032405
Domain	M/V/L/I-tRNA-synth_anticd-bd	IARS1 LARS2	8.32e-04	6	141	2	IPR013155
Domain	-	IARS1 LARS2	8.32e-04	6	141	2	3.90.740.10
Domain	ARM-type_fold	DOCK1 TNPO2 PSMD2 PPP4R3A ARFGEF3 HEATR6 PIK3CA GCN1 AGBL1	1.10e-03	339	141	9	IPR016024
Domain	aa-tRNA-synth_Ia	IARS1 LARS2	1.16e-03	7	141	2	IPR002300
Domain	tRNA-synt_1	IARS1 LARS2	1.16e-03	7	141	2	PF00133
Domain	FHA	KIF1A CEP170 KIF14	1.20e-03	28	141	3	SM00240
Domain	Chorein_N	ATG2B VPS13B	1.54e-03	8	141	2	PF12624
Domain	VPS13_N	ATG2B VPS13B	1.54e-03	8	141	2	IPR026854
Domain	FHA_DOMAIN	KIF1A CEP170 KIF14	1.62e-03	31	141	3	PS50006
Domain	FHA	KIF1A CEP170 KIF14	1.62e-03	31	141	3	PF00498
Pathway	PID_VEGFR1_PATHWAY	HIF1A NRP1 PIK3CA NOS3	5.11e-05	26	113	4	M226
Pathway	BIOCARTA_VEGF_PATHWAY	HIF1A PIK3CA EIF1AX NOS3	5.96e-05	27	113	4	M12975
Pathway	PID_NETRIN_PATHWAY	DOCK1 PIK3CA MAP2K1 MAP2K2	1.18e-04	32	113	4	M108
Pathway	BIOCARTA_MET_PATHWAY	DOCK1 PIK3CA MAP2K1 MAP2K2	1.34e-04	33	113	4	M19358
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	NAB2 PIK3CA MAPKAPK3 MAP2K1 MAP2K2	1.47e-04	63	113	5	MM14714
Pathway	WP_HEPATOCYTE_GROWTH_FACTOR_RECEPTOR_SIGNALING	DOCK1 PIK3CA MAP2K1 MAP2K2	1.51e-04	34	113	4	M39383
Pathway	WP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY	PIK3CA MAPKAPK3 MAP2K1 MAP2K2	2.11e-04	37	113	4	M42558
Pathway	SA_TRKA_RECEPTOR	PIK3CA MAP2K1 MAP2K2	3.14e-04	17	113	3	M18895
Pathway	BIOCARTA_HCMV_PATHWAY	PIK3CA MAP2K1 MAP2K2	3.14e-04	17	113	3	M8353
Pathway	BIOCARTA_HCMV_PATHWAY	PIK3CA MAP2K1 MAP2K2	3.14e-04	17	113	3	MM1408
Pathway	REACTOME_SIGNALING_BY_NTRKS	NAB2 PIK3CA MAPKAPK3 MAP2K1 MAP2K2	3.34e-04	75	113	5	MM14652
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	PIK3CA MAPKAPK3 MAP2K1 MAP2K2 NOS3	3.56e-04	76	113	5	M1749
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	INTS12 RIMKLA MINK1 MAST2 MELK CDC14A ITK MADD CEP170 ARFGEF3 MAST4 CSNK1D CSNK1E PI4KB KIF14 USP54 MAP2K1 MAP2K2 ARAP2 DYRK2	4.49e-10	861	143	20	36931259
Pubmed	Synthetic lethal interaction between PI3K/Akt/mTOR and Ras/MEK/ERK pathway inhibition in rhabdomyosarcoma.	PIK3CA MAP2K1 MAP2K2	2.71e-07	4	143	3	23684925
Pubmed	LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.	MAT2A ANXA11 MAST2 CSNK1D ALDH1L2 MAP2K2	3.22e-07	66	143	6	36398858
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NRBP1 KIF1A TNPO2 MAT2A PSMD2 DARS1 SMARCAD1 PRDM4 SEC31B USP16 MADD FAN1 HEATR6 ZNF451 HPF1 PPME1 EXOC1 USP54 TBC1D23 PREX1	3.38e-07	1285	143	20	35914814
Pubmed	Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.	MAP2K1 MAP2K2 NOS3	6.77e-07	5	143	3	22465219
Pubmed	Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.	PIK3CA MAP2K1 MAP2K2	6.77e-07	5	143	3	24011934
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP ATMIN DGCR2 TBC1D9B ANXA11 MTMR8 LARS2 MAST2 ZZEF1 MADD FAT1 NEK8 ARHGAP44 GCN1 PREX1 D2HGDH PKN3 ARAP1	7.21e-07	1105	143	18	35748872
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	ITK CSNK1D CSNK1E MAP2K1 MAP2K2 PKN3	8.75e-07	78	143	6	17192257
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 SRSF2 ANXA11 PSMD2 SMARCAD1 SMC2 SEC31B MELK CDC16 EXOC1 MAP2K2 GCN1 ARAP1	9.31e-07	582	143	13	20467437
Pubmed	Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.	USP16 MELK CSNK1E NEK8 PEX5 ENG NOS3	9.62e-07	126	143	7	24319055
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	IARS1 TNPO2 RNF213 PSMD2 DARS1 SMC2 ARFGEF3 GCN1	9.78e-07	183	143	8	23956138
Pubmed	Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes.	HIF1A NRP1 NOS3	1.35e-06	6	143	3	18785001
Pubmed	Association of polymorphisms of angiogenesis genes with breast cancer.	HIF1A NRP1 NOS3	2.35e-06	7	143	3	17891484
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	SRSF2 IARS1 MAT2A PSMD2 DARS1 RO60 SMC2 CEP170 MAP2K1 GCN1	4.55e-06	383	143	10	29331416
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SRSF2 IARS1 MAT2A KCMF1 PSMD2 DARS1 RO60 MAGT1 SMC2 USP16 ABCE1 CBX5 HPF1 PPME1 CRYBG1 MAP2K1 MAP2K2 GCN1	8.39e-06	1318	143	18	30463901
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DAB2IP IARS1 ATG2B MAGT1 SMC2 MELK PPP4R3A CEP170 CDC16 PI4KB NEK8 ARHGAP44 EXOC1 GCN1 ATP2B2 PKN3 MAST3 DYRK2	8.65e-06	1321	143	18	27173435
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	IARS1 MAT2A ANXA11 NAB2 RNF213 PSMD2 DARS1 MAGT1 SMC2 CEP170 HEATR6 SERPINB13 ABCE1 EIF1AX PPME1 SERPINB1 EXOC1 GCN1	1.37e-05	1367	143	18	32687490
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	HIF1A SRSF2 ACAA1 IARS1 MAT2A KCMF1 PSMD2 DARS1 SMC2 PIK3CA ABCE1 CBX5 CSNK1D CSNK1E MAP2K1 MAP2K2 GCN1	1.56e-05	1247	143	17	27684187
Pubmed	Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.	MAP2K1 MAP2K2	1.68e-05	2	143	2	9563949
Pubmed	Mek2 is dispensable for mouse growth and development.	MAP2K1 MAP2K2	1.68e-05	2	143	2	12832465
Pubmed	Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.	MAP2K1 MAP2K2	1.68e-05	2	143	2	19014680
Pubmed	CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.	CSNK1D CSNK1E	1.68e-05	2	143	2	24424021
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	1.68e-05	2	143	2	22318685
Pubmed	The ADP-ribose reactive NUDIX hydrolase isoforms can modulate HIF-1α in cancer cells.	HIF1A NUDT9	1.68e-05	2	143	2	30190133
Pubmed	Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.	PREX2 PREX1	1.68e-05	2	143	2	20694145
Pubmed	Vasculogenic mimicry of HT1080 tumour cells in vivo: critical role of HIF-1α-neuropilin-1 axis.	HIF1A NRP1	1.68e-05	2	143	2	23185562
Pubmed	Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.	CSNK1D CSNK1E	1.68e-05	2	143	2	9632646
Pubmed	Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells.	MAP2K1 MAP2K2	1.68e-05	2	143	2	26625317
Pubmed	Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation.	MAP2K1 MAP2K2	1.68e-05	2	143	2	21699731
Pubmed	Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.	MAP2K1 MAP2K2	1.68e-05	2	143	2	17419998
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	1.68e-05	2	143	2	29749642
Pubmed	METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.	METTL15P1 METTL15	1.68e-05	2	143	2	32573735
Pubmed	Life and death of sensory hair cells expressing constitutively active TRPML3.	ATP2B2 MCOLN3	1.68e-05	2	143	2	19299509
Pubmed	MEK1 and MEK2 differentially control the duration and amplitude of the ERK cascade response.	MAP2K1 MAP2K2	1.68e-05	2	143	2	23735655
Pubmed	The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma.	MAP2K1 MAP2K2	1.68e-05	2	143	2	35069558
Pubmed	Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice.	METTL15P1 METTL15	1.68e-05	2	143	2	35682734
Pubmed	The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility.	MAP2K1 MAP2K2	1.68e-05	2	143	2	21527500
Pubmed	Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.	MAP2K1 MAP2K2	1.68e-05	2	143	2	19383924
Pubmed	MEK1 and MEK2, different regulators of the G1/S transition.	MAP2K1 MAP2K2	1.68e-05	2	143	2	15284233
Pubmed	Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations.	MAP2K1 MAP2K2	1.68e-05	2	143	2	19156172
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	1.68e-05	2	143	2	31234428
Pubmed	P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.	PREX2 PREX1	1.68e-05	2	143	2	18334636
Pubmed	p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.	MAP2K1 MAP2K2	1.68e-05	2	143	2	12839928
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	1.68e-05	2	143	2	29448301
Pubmed	MEK1/2 inhibition promotes Taxotere lethality in mammary tumors in vivo.	MAP2K1 MAP2K2	1.68e-05	2	143	2	16957420
Pubmed	T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate.	MAP2K1 MAP2K2	1.68e-05	2	143	2	19144315
Pubmed	Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.	MAP2K1 MAP2K2	1.68e-05	2	143	2	19500021
Pubmed	Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.	MAP2K1 MAP2K2	1.68e-05	2	143	2	22197931
Pubmed	FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma.	HIF1A FAT1	1.68e-05	2	143	2	27536856
Pubmed	Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas.	MAP2K1 MAP2K2	1.68e-05	2	143	2	27956260
Pubmed	Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options.	MAP2K1 MAP2K2	1.68e-05	2	143	2	17981815
Pubmed	Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.	CSNK1D CSNK1E	1.68e-05	2	143	2	19043076
Pubmed	Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.	MAP2K1 MAP2K2	1.68e-05	2	143	2	28746311
Pubmed	Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases.	MAP2K1 MAP2K2	1.68e-05	2	143	2	30087384
Pubmed	P-Rex1 and P-Rex2 RacGEFs and cancer.	PREX2 PREX1	1.68e-05	2	143	2	28710285
Pubmed	Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells.	HIF1A MAT2A	1.68e-05	2	143	2	21460102
Pubmed	Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity.	MAP2K1 MAP2K2	1.68e-05	2	143	2	22833572
Pubmed	Significance of HIF-1α and CD105 in establishing oral squamous cell carcinoma associated with oral submucous fibrosis a distinct clinicopathological entity.	HIF1A ENG	1.68e-05	2	143	2	35381759
Pubmed	Heme changes HIF-α, eNOS and nitrite production in HUVECs after simvastatin, HU, and ascorbic acid therapies.	HIF1A NOS3	1.68e-05	2	143	2	27089822
Pubmed	ERK1/2 can feedback-regulate cellular MEK1/2 levels.	MAP2K1 MAP2K2	1.68e-05	2	143	2	26163823
Pubmed	Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism.	MAP2K1 MAP2K2	1.68e-05	2	143	2	36189831
Pubmed	Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.	MAP2K1 MAP2K2	1.68e-05	2	143	2	22805292
Pubmed	Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.	MAP2K1 MAP2K2	1.68e-05	2	143	2	22805291
Pubmed	Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway.	MAP2K1 MAP2K2	1.68e-05	2	143	2	35975983
Pubmed	Inhibitors of the mitogen-activated protein kinase kinase 1/2 signaling pathway clear prion-infected cells from PrPSc.	MAP2K1 MAP2K2	1.68e-05	2	143	2	16162927
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	1.68e-05	2	143	2	27076759
Pubmed	Regulation of intracellular MEK1/2 translocation in mouse oocytes: cytoplasmic dynein/dynactin-mediated poleward transport and cyclin B degradation-dependent release from spindle poles.	MAP2K1 MAP2K2	1.68e-05	2	143	2	17507801
Pubmed	Expression of hypoxia-inducing factor-1 alpha and endoglin in intimal hyperplasia of the middle cerebral artery of patients with Moyamoya disease.	HIF1A ENG	1.68e-05	2	143	2	17290185
Pubmed	[Combined inhibition of PI3K and MEK has synergistic inhibitory effect on the proliferation of cisplatin-resistant ovarian cancer cells].	PIK3CA MAP2K1	1.68e-05	2	143	2	24909280
Pubmed	Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.	MAP2K1 MAP2K2	1.68e-05	2	143	2	8529659
Pubmed	Quadruple-editing of the MAPK and PI3K pathways effectively blocks the progression of KRAS-mutated colorectal cancer cells.	PIK3CA MAP2K1	1.68e-05	2	143	2	34185934
Pubmed	Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.	MAP2K1 MAP2K2	1.68e-05	2	143	2	1381507
Pubmed	Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.	CSNK1D CSNK1E	1.68e-05	2	143	2	25404202
Pubmed	[Mek1 and Mek2 functions in the formation of the blood placental barrier].	MAP2K1 MAP2K2	1.68e-05	2	143	2	22549869
Pubmed	The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.	MAP2K1 MAP2K2	1.68e-05	2	143	2	23480967
Pubmed	Identification and characterization of a novel chemotype MEK inhibitor able to alter the phosphorylation state of MEK1/2.	MAP2K1 MAP2K2	1.68e-05	2	143	2	23237773
Pubmed	Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice.	ENG NOS3	1.68e-05	2	143	2	19820034
Pubmed	ABCE1 selectively promotes HIF-1α transactivation of angiogenic gene expression.	HIF1A ABCE1	1.68e-05	2	143	2	37738929
Pubmed	Analysis of minK and eNOS genes as candidate loci for predisposition to non-valvular atrial fibrillation.	MINK1 NOS3	1.68e-05	2	143	2	16760206
Pubmed	Cisplatin inhibits MEK1/2.	MAP2K1 MAP2K2	1.68e-05	2	143	2	26155939
Pubmed	Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.	NOS3 ARAP1	1.68e-05	2	143	2	22357923
Pubmed	Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin.	MAP2K1 MAP2K2	1.68e-05	2	143	2	19198628
Pubmed	Effect of hypoxia on HIF-1α and NOS3 expressions in CD34+ cells of JAK2V617F-positive myeloproliferative neoplasms.	HIF1A NOS3	1.68e-05	2	143	2	37075583
Pubmed	Extracellular matrix and HIF-1 signaling: the role of prolidase.	HIF1A PEPD	1.68e-05	2	143	2	17999410
Pubmed	Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo.	MAP2K1 MAP2K2	1.68e-05	2	143	2	15979847
Pubmed	ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro.	MAP2K1 MAP2K2	1.68e-05	2	143	2	25491074
Pubmed	Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2.	MAP2K1 MAP2K2	1.68e-05	2	143	2	20172001
Pubmed	Chromosome mapping of the human genes encoding the MAP kinase kinase MEK1 (MAP2K1) to 15q21 and MEK2 (MAP2K2) to 7q32.	MAP2K1 MAP2K2	1.68e-05	2	143	2	10828601
Pubmed	The effect of estrogen on prolidase-dependent regulation of HIF-1α expression in breast cancer cells.	HIF1A PEPD	1.68e-05	2	143	2	23549681
Pubmed	Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse.	MAP2K1 MAP2K2	1.68e-05	2	143	2	22561024
Pubmed	An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.	CSNK1D CSNK1E	1.68e-05	2	143	2	22981886
Pubmed	Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.	MAP2K1 MAP2K2	1.68e-05	2	143	2	15543157
Pubmed	VEGF production by primary human renal proximal tubular cells: requirement of HIF-1, PI3-kinase and MAPKK-1 signaling.	HIF1A MAP2K1	1.68e-05	2	143	2	15665520
Pubmed	Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers.	MAP2K1 MAP2K2	1.68e-05	2	143	2	18390968
Pubmed	Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.	PIK3CA MAP2K1 MAP2K2	1.89e-05	13	143	3	27799550
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	NRBP1 SRSF2 IARS1 TNPO2 PSMD2 RO60 SMC2 MAST2 PPP4R3A AZIN1 LIG4 CSNK1D CSNK1E PI4KB GCN1 PREX1 D2HGDH	2.26e-05	1284	143	17	17353931
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SRSF2 KIF1A IARS1 MAT2A PEPD PSMD2 DARS1 RO60 SMARCAD1 SMC2 MAST2 ABCE1 CSNK1E CDC16 KIF14 MYO18B DNAH5 GCN1	2.38e-05	1425	143	18	30948266
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	BLOC1S4 ANXA11 DARS1 CEP170 SERPINB1 USP54 MAP2K1 MAP2K2	2.71e-05	288	143	8	38496616
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	NRBP1 IARS1 MAT2A KCMF1 PEPD PSMD2 DARS1 RO60 SMARCAD1 SMC2 ZZEF1 PPP4R3A DCUN1D1 ABCE1 EIF1AX PEX5 PPME1 GCN1	3.12e-05	1455	143	18	22863883
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	DOCK1 IARS1 MAT2A MINK1 ATG2B PSMD2 DARS1 MAGT1 SMC2 CEP170 ABCE1 GCN1	3.87e-05	708	143	12	39231216
Interaction	EDNRB interactions	INTS12 TNPO2 NRP1 EXOC1 ATP2B2 NOS3	2.84e-07	39	141	6	int:EDNRB
Interaction	FAM83D interactions	KCMF1 CEP170 CSNK1D CSNK1E CDC16 KIF14 MAP2K2	1.73e-06	82	141	7	int:FAM83D
Interaction	YWHAH interactions	DAB2IP INTS12 RIMKLA MINK1 PSMD2 MAST2 MELK CDC14A MADD CEP170 ARFGEF3 MAST4 PIK3CA ABCE1 CSNK1D CSNK1E PI4KB KIF14 USP54 MAP2K1 MAP2K2 MAST3 ARAP2	2.39e-06	1102	141	23	int:YWHAH
Interaction	FZD10 interactions	TBC1D9B INTS12 TNPO2 SMC2 NRP1 ATP2B2	6.78e-06	66	141	6	int:FZD10
Interaction	MAT2B interactions	MAT1A IARS1 MAT2A NAB2 PEPD DARS1 KIF14	1.09e-05	108	141	7	int:MAT2B
Interaction	STRN3 interactions	MINK1 ATG2B LIG4 EIF1AX PPME1 EXOC1 METTL15 PKN3	1.80e-05	161	141	8	int:STRN3
Interaction	RGSL1 interactions	MAGT1 DCUN1D1 D2HGDH	1.83e-05	8	141	3	int:RGSL1
Interaction	TNFSF13B interactions	ARSK TNPO2 SMC2 ARFGEF3 KIF14 EXOC1 GCN1	2.06e-05	119	141	7	int:TNFSF13B
Interaction	NPTN interactions	TNPO2 RNF213 SSTR3 LARS2 ARFGEF3 HEATR6 KIF14 GCN1 ATP2B2 D2HGDH	2.68e-05	278	141	10	int:NPTN
Interaction	ATP8A2 interactions	ZBTB8OS SMARCAD1 SSTR3	2.73e-05	9	141	3	int:ATP8A2
Interaction	SLAMF1 interactions	INTS12 ARSK ATG2B FAT1 HEATR6 ATP2B2 D2HGDH	2.83e-05	125	141	7	int:SLAMF1
Interaction	C19orf38 interactions	TBC1D9B TNPO2 RNF213 SMC2 KIF14 ATP2B2	3.13e-05	86	141	6	int:C19orf38
Interaction	SUB1 interactions	SRSF2 MINK1 RO60 SMC2 PPP4R3A FAN1 CBX5 EIF1AX MAP2K2	6.20e-05	247	141	9	int:SUB1
Interaction	CSNK1A1 interactions	DAB2IP MAT2A TMPRSS11B NRP1 CEP170 LIG4 CSNK1D CSNK1E KIF14 MAP2K1 GCN1	7.83e-05	381	141	11	int:CSNK1A1
Interaction	EFNB1 interactions	DAB2IP TBC1D9B TNPO2 MINK1 RNF213 SSTR3 TMPRSS11B KIF14 PKN3	7.91e-05	255	141	9	int:EFNB1
Interaction	TOP3B interactions	DAB2IP ATMIN DGCR2 TBC1D9B IARS1 ANXA11 KCMF1 MTMR8 DARS1 LARS2 MAST2 ZZEF1 CDC14A MADD FAT1 CBX5 NEK8 ARHGAP44 KIF14 GCN1 PREX1 D2HGDH PKN3 ARAP1	8.20e-05	1470	141	24	int:TOP3B
Interaction	COMTD1 interactions	TBC1D9B INTS12 IARS1 TNPO2 DARS1 SMC2 PPP4R3A GCN1	8.39e-05	200	141	8	int:COMTD1
Interaction	FGD4 interactions	DAB2IP DOCK1 PREX2 KIF14 PREX1	8.54e-05	64	141	5	int:FGD4
Interaction	NPSR1 interactions	LYG2 SERPINB13 CSNK1D CRYBG1	1.02e-04	35	141	4	int:NPSR1
Interaction	CTAG2 interactions	TBC1D9B INTS12 MELK KIF14	1.02e-04	35	141	4	int:CTAG2
Interaction	STK11 interactions	HIF1A SERPINB13 PIK3CA DNAH17 PEX5 SERPINB1 TBC1D23 MAP2K1 D2HGDH DNASE1	1.02e-04	326	141	10	int:STK11
Interaction	SNX21 interactions	ATG2B MELK MADD HEATR6 VPS13B	1.06e-04	67	141	5	int:SNX21
Interaction	MICOS13 interactions	HIF1A MFSD4A TMPRSS11B NRP1 PKN3	1.22e-04	69	141	5	int:MICOS13
Interaction	DOCK5 interactions	DOCK1 KIF1A ATG2B MADD PPP4R3A VPS13B	1.31e-04	111	141	6	int:DOCK5
Interaction	LANCL1 interactions	NRBP1 TBC1D9B TMPRSS11B NRP1 NRBP2 ENG	1.37e-04	112	141	6	int:LANCL1
Interaction	BSG interactions	INTS12 TNPO2 RNF213 SSTR3 LARS2 TMPRSS11B NRP1 HEATR6 PIK3CA CBX5 EXOC1 METTL15 GCN1 ATP2B2	1.41e-04	631	141	14	int:BSG
Interaction	PEMT interactions	LYG2 SERPINB13 PPME1 CRYBG1	1.73e-04	40	141	4	int:PEMT
Cytoband	3q26.3	DCUN1D1 PIK3CA	9.58e-05	5	143	2	3q26.3
GeneFamily	Mitogen-activated protein kinase kinases	MAP2K1 MAP2K2	4.84e-04	7	88	2	653
GeneFamily	PDZ domain containing	MAST2 PREX2 MAST4 PREX1 MAST3	8.79e-04	152	88	5	1220
GeneFamily	AAA ATPases\|Peroxins	PEX16 PEX5	2.69e-03	16	88	2	957
GeneFamily	Dyneins, axonemal	DNAH17 DNAH5	3.04e-03	17	88	2	536
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	KIF1A ITK PREX1 ARAP1 ARAP2	3.33e-03	206	88	5	682
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KCMF1 ZZEF1	3.41e-03	18	88	2	91
GeneFamily	Aminoacyl tRNA synthetases, Class I	IARS1 LARS2	3.80e-03	19	88	2	131
Coexpression	GSE45881_CXCR6HI_VS_CXCR1LO_COLONIC_LAMINA_PROPRIA_UP	MINK1 ZZEF1 CDC14A MAST4 ZNF451 PPME1 CRYBG1 EXOC1 ARAP2 DYRK2	1.58e-07	200	143	10	M9889
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	DOCK1 HIF1A LARS2 MAST2 ZZEF1 ABLIM3 MELK AZIN1 CEP170 FAT1 ABCE1 CDC16 ZNF451 KIF14 MAP2K1 VPS13B ARAP2	4.54e-06	856	143	17	M4500
Coexpression	GSE46468_LUNG_INNATE_LYMPHOID_CELL_VS_SPLEEN_CD4_TCELL_DN	INTS12 IARS1 MAT2A NAB2 ITK ABCE1 CSNK1E ARAP2	1.42e-05	199	143	8	M8444
Coexpression	GSE36078_WT_VS_IL1R_KO_LUNG_DC_DN	DDX49 ARSK LARS2 PEX16 SERPINB1 CRYBG1 PREX1 DYRK2	1.47e-05	200	143	8	M9290
Coexpression	NAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP	TBC1D9B SLC7A7 MAST2 SEC31B CDC14A CBX5 CDC16 ZNF451 PEX5 SERPINB1	3.52e-05	367	143	10	M41159
Coexpression	GSE37532_WT_VS_PPARG_KO_LN_TCONV_DN	PEPD SMC2 MAST2 CDC14A NRP1 AZIN1 HPF1	7.26e-05	185	143	7	M9004
Coexpression	GSE17974_0.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP	ATMIN HIF1A SRSF2 PRDM4 ZZEF1 CDC14A AZIN1	1.04e-04	196	143	7	M4244
Coexpression	GSE42021_TREG_PLN_VS_TREG_PRECURSORS_THYMUS_UP	ATMIN ITK MADD LIG4 FAT1 PI4KB PPME1	1.08e-04	197	143	7	M9569
Coexpression	GSE25088_WT_VS_STAT6_KO_MACROPHAGE_DN	DOCK1 MAT2A MAST2 MELK PPME1 KIF14 DYRK3	1.14e-04	199	143	7	M8031
Coexpression	GSE24142_DN2_VS_DN3_THYMOCYTE_ADULT_DN	MORC1 IARS1 NAB2 DARS1 NRP1 ABCE1 ZNF451	1.14e-04	199	143	7	M4567
Coexpression	GSE13522_CTRL_VS_T_CRUZI_G_STRAIN_INF_SKIN_UP	INTS12 BLOC1S4 MFSD4A NRP1 FAH CDC16 MAPKAPK3	1.14e-04	199	143	7	M2922
Coexpression	GSE9037_CTRL_VS_LPS_1H_STIM_IRAK4_KO_BMDM_DN	MAT2A MFSD4A NRP1 IFI44L TBC1D23 ECHDC2 PKN3	1.18e-04	200	143	7	M5808
Coexpression	GSE46606_UNSTIM_VS_CD40L_IL2_IL5_3DAY_STIMULATED_IRF4MID_SORTED_BCELL_DN	BLOC1S4 RNF213 NUDT9 NRP1 AZIN1 ARAP2 DYRK2	1.18e-04	200	143	7	M9837
Coexpression	GSE17721_LPS_VS_PAM3CSK4_24H_BMDC_DN	IARS1 TNPO2 MAT2A NAB2 ABCE1 HPF1 MORN3	1.18e-04	200	143	7	M3931
Coexpression	GSE21380_NON_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_DN	HIF1A IARS1 MAT2A MADD AZIN1 PREX1 MCOLN3	1.18e-04	200	143	7	M7505
Coexpression	GSE8835_CD4_VS_CD8_TCELL_CLL_PATIENT_UP	NAAA BLOC1S4 RNF213 PRDM4 EIF1AX IFI44L MCOLN3	1.18e-04	200	143	7	M6256
Coexpression	GSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_1MONTH_POST_DX_UP	ATMIN HIF1A DDX49 PSMD2 AZIN1 EIF1AX MAP2K1	1.18e-04	200	143	7	M5777
CoexpressionAtlas	kidney_adult_RenCorpuscGlomer_k-means-cluster#1_top-relative-expression-ranked_200	PREX2 NRP1 ENG ARAP2	4.34e-05	30	140	4	gudmap_kidney_adult_RenCorpuscGlomer_k1_200
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000	RO60 MAGT1 SMC2 CDC14A PREX2 CEP170 MAST4 ZNF43 CBX5 ZNF451	5.78e-05	323	140	10	gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlas	kidney_adult_GlomCapSys_Tie2_k-means-cluster#4_top-relative-expression-ranked_200	PREX2 NRP1 ENG ARAP2	6.38e-05	33	140	4	gudmap_kidney_adult_GlomCapSys_Tie2_k4_200
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000	ANO1 RO60 MAGT1 SMC2 CDC14A MAST4 PIK3CA CBX5 ZNF451	8.98e-05	275	140	9	gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlas	kidney_adult_RenCorpuscGlomer_k-means-cluster#1_top-relative-expression-ranked_100	PREX2 NRP1 ENG	9.68e-05	14	140	3	gudmap_kidney_adult_RenCorpuscGlomer_k1_100
ToppCell	356C-Lymphocytic-ILC-ILC-2\|ILC / Donor, Lineage, Cell class and subclass (all cells)	ATG2B SEC31B CEP170 LIG4 HEATR6 DNAH17 DYRK3	1.43e-06	172	143	7	4977e1f4deae781750e27a8054deccd336cfb74a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 MAST4 ARHGAP44 USP54 DNAH5 AGBL1 FBN3	2.40e-06	186	143	7	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	ARFGEF3 MAST4 ARHGAP44 USP54 DNAH5 AGBL1 LRP2BP	2.57e-06	188	143	7	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	facs-SCAT-Fat-3m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	2.86e-06	191	143	7	a0018f88f7132477cc467ee15db029a585290595
ToppCell	facs-SCAT-Fat-3m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	2.86e-06	191	143	7	6b9bbf4a63d4e9a8075bb06c2aa644fcf4ee88b8
ToppCell	facs-SCAT-Fat-3m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	2.86e-06	191	143	7	90f0c193dce267a4f1a9b2501f636dafd0a34cf7
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 SEC31B CDC14A ITK IFI44L VPS13B ARAP2	3.06e-06	193	143	7	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABLIM3 PREX2 MAST4 IFI44L ENG NOS3 PKN3	3.51e-06	197	143	7	e8e879b7634a29569061d3515d180784094a31e7
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 ARFGEF3 MAST4 ARHGAP44 USP54 AGBL1 LRP2BP	3.75e-06	199	143	7	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 CDC14A ITK ZNF451 IFI44L VPS13B ARAP2	3.75e-06	199	143	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABLIM3 PREX2 GRK1 MAST4 SV2C NOS3 PKN3	3.75e-06	199	143	7	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PREX2 MAST4 IFI44L ENG ATP2B2 NOS3 PKN3	3.87e-06	200	143	7	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	FAT1 MAST4 OR56B1 USP54 DNAH5 AGBL1	1.46e-05	163	143	6	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	COVID-19_Severe-CD4+_T_activated\|COVID-19_Severe / Disease condition and Cell class	SSTR3 CDC14A ITK SERPINB13 IFI44L SIGLEC1	1.62e-05	166	143	6	0f138dbafad6f83975944e8f6398411127b150cc
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CDC14A HEATR6 CRYBG1 METTL15 PREX1 DYRK3	1.68e-05	167	143	6	4b6853efefea5178280ba7c31facda0fbd1cc469
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNH7 SMC2 MELK SLC6A2 NOS3 PKN3	2.18e-05	175	143	6	d43ae33a6256606ce848247cad32d74f21b38988
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABLIM3 NRP1 MAST4 DNAH17 ENG NOS3	2.18e-05	175	143	6	7be76d39e1a4f4ac709672cd2d409a2523a083ce
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	2.33e-05	177	143	6	ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	2.33e-05	177	143	6	f471f7747d6e8db7546899019af9508f48a14f89
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	2.33e-05	177	143	6	cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 ANO1 PREX2 NRP1 FAH FBN3	2.64e-05	181	143	6	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEC31B AZIN1 ARHGAP44 ATP2B2 NOS3 PKN3	2.64e-05	181	143	6	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	MFSD4A ARFGEF3 MAST4 SERPINB1 USP54 DNAH5	2.64e-05	181	143	6	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LYG2 PREX2 MAST4 IFI44L ENG PKN3	2.72e-05	182	143	6	0639011cdd1c437ea8b7230896a4e6e5d7244ac2
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SSTR3 ITK PPP4R3A MAST4 IFI44L GCN1	2.72e-05	182	143	6	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SSTR3 ITK PPP4R3A MAST4 IFI44L GCN1	2.72e-05	182	143	6	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABLIM3 PREX2 MAST4 ENG ATP2B2 NOS3	2.72e-05	182	143	6	840427d1c23d60482c943ff006b14007ed44d247
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SSTR3 ITK PPP4R3A MAST4 IFI44L GCN1	2.72e-05	182	143	6	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SSTR3 ITK PPP4R3A MAST4 IFI44L GCN1	2.72e-05	182	143	6	4cb182ef39be2044a6ad7266f332d4177591e550
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KCNH7 KIF1A SSTR3 ARFGEF3 SV2C MCOLN3	2.81e-05	183	143	6	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	COVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Mild / Disease group, lineage and cell class	SSTR3 ITK PPP4R3A MAST4 IFI44L GCN1	2.81e-05	183	143	6	7717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCell	(4)_Endothelial_cells-(40)_EC-arterial\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	2.90e-05	184	143	6	7e1a2971321ddcfa00d78d3e3ba7960e532f9392
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DGCR2 SEC31B CDC14A ITK CRYBG1 DYRK2	2.90e-05	184	143	6	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAAA ACAA1 SERPINB1 SIGLEC1 PREX1 MCOLN3	2.90e-05	184	143	6	8e5fc2bdd3071e782aa8c56b8a39f8ea8f03f623
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MFSD4A FAT1 MAST4 USP54 DNAH5 AGBL1	2.90e-05	184	143	6	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	MFSD4A FAT1 MAST4 USP54 DNAH5 AGBL1	2.98e-05	185	143	6	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MFSD4A ARFGEF3 FAT1 MAST4 USP54 AGBL1	2.98e-05	185	143	6	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 ODAD1 NEK8 DNAH5 METTL15 MORN3	2.98e-05	185	143	6	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	MFSD4A ARFGEF3 MAST4 ARHGAP44 USP54 DNAH5	2.98e-05	185	143	6	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP PREX2 NRP1 NRK ENG NOS3	3.08e-05	186	143	6	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	10x5'v1-week_17-19-Lymphocytic_T-T_NK-NK_T_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RNF213 SEC31B ITK ARAP2 LRP2BP MORN3	3.17e-05	187	143	6	3301e0fca8c436d136c71f1a8fd59b3bb11bdd83
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	3.27e-05	188	143	6	05de6677f9bb4b00fed47f4b72f4a2cd507cb0f2
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	IARS1 ARFGEF3 MAST4 ARHGAP44 DNAH5 AGBL1	3.27e-05	188	143	6	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	MELK ITK ARFGEF3 MAST4 DNAH5 ARAP2	3.27e-05	188	143	6	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	facs-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.36e-05	189	143	6	f60ac60ab9b317a0196f0cbbe520ef7dbd19ac11
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	3.36e-05	189	143	6	8ced0381ea042ba47680a02b617a2368fa2c54c8
ToppCell	facs-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.36e-05	189	143	6	e3d65417997bdd3f9c312c0977dceb6eca061029
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	3.36e-05	189	143	6	403a82bb416aed13b9d31411ad17bdc4ce2a95fb
ToppCell	facs-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.36e-05	189	143	6	5559af03d9d612bb8dcf825e45744a9f8332bac8
ToppCell	facs-SCAT-Fat-18m-Endothelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.46e-05	190	143	6	b0c9dae8189d407c94964c6bfe3ef92035245357
ToppCell	facs-SCAT-Fat-18m-Endothelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.46e-05	190	143	6	ee63dc04e91ad49aa7820c98e97261176ecebaa6
ToppCell	facs-SCAT-Fat-18m-Endothelial-endothelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.46e-05	190	143	6	0e50808bfc3d0820524c8470ae3e8250819d65b2
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH7 KIF1A RIMKLA ARFGEF3 SV2C MCOLN3	3.46e-05	190	143	6	b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PREX2 SLC6A2 MAST4 ENG NOS3 PKN3	3.46e-05	190	143	6	ec6b8e2852e1cce0217ff61243defe98b2351640
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KCNH7 KIF1A SSTR3 ARFGEF3 SV2C MCOLN3	3.46e-05	190	143	6	b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABLIM3 PREX2 MAST4 IFI44L ENG PKN3	3.57e-05	191	143	6	adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCell	facs-BAT-Fat-18m-Endothelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.67e-05	192	143	6	3a99c521c599a289ee2309d97be5ceb99f8aa220
ToppCell	facs-BAT-Fat-18m-Endothelial-endothelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.67e-05	192	143	6	f9777e0fdd86c2a514f05a42502888329a94b396
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIF1A NAB2 SLC7A7 CEP170 IFI44L SIGLEC1	3.67e-05	192	143	6	f14ee74ac3275601749a23c5efe39c2413a62e1a
ToppCell	facs-BAT-Fat-18m-Endothelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.67e-05	192	143	6	562e15876088af9189744c9b2de5c4863d7f15fd
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	ARFGEF3 MAST4 ARHGAP44 USP54 DNAH5 AGBL1	3.67e-05	192	143	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIF1A NAB2 SLC7A7 CEP170 IFI44L SIGLEC1	3.67e-05	192	143	6	0219093e7921a0db78053aee13ec480b520f5662
ToppCell	facs-BAT-Fat-3m-Endothelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.78e-05	193	143	6	e340064cd146deac03f2d0fd43e2e218bb6057c9
ToppCell	droplet-Fat-Mat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 ENG NOS3 PKN3	3.78e-05	193	143	6	54024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCell	droplet-Fat-Mat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 ENG NOS3 PKN3	3.78e-05	193	143	6	81d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	MFSD4A ARFGEF3 FAT1 MAST4 USP54 DNAH5	3.78e-05	193	143	6	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PREX2 IFI44L ENG PREX1 NOS3 PKN3	3.78e-05	193	143	6	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	facs-BAT-Fat-3m-Endothelial-endothelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.78e-05	193	143	6	a211b386fd0fb9da9937361d29d90925a72c9715
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 MAST4 ARHGAP44 USP54 AGBL1 FBN3	3.78e-05	193	143	6	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	facs-BAT-Fat-3m-Endothelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 NRP1 ENG NOS3	3.78e-05	193	143	6	3086c33f4d6fab66966818737f95ae4d6b2615b0
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HIF1A NAAA NRP1 CEP170 MAP2K1 PREX1	3.89e-05	194	143	6	663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PREX2 SLC6A2 SERPINB1 ENG NOS3 PKN3	3.89e-05	194	143	6	e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCell	droplet-Fat-Mat-18m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP ABLIM3 PREX2 ENG NOS3 PKN3	3.89e-05	194	143	6	74d0eaa76f6d9af14110dfe5b4bf9751b99ff6e3
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PREX2 SLC6A2 SERPINB1 ENG NOS3 PKN3	3.89e-05	194	143	6	4b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABLIM3 PREX2 NRP1 ENG NOS3 PKN3	4.01e-05	195	143	6	4db30b3bc65c25626f828cd4f867f20c71809898
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARFGEF3 MAST4 ARHGAP44 USP54 DNAH5 LRP2BP	4.01e-05	195	143	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	Control-Epithelial\|Control / Disease state, Lineage and Cell class	ARFGEF3 MAST4 ARHGAP44 USP54 DNAH5 AGBL1	4.01e-05	195	143	6	1798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PREX2 IFI44L ENG PREX1 NOS3 PKN3	4.01e-05	195	143	6	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PREX2 NRP1 MAST4 ENG PREX1 NOS3	4.24e-05	197	143	6	98e34e8612f111bb667a574de1faaa785d318ca4
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LYG2 RNF213 CDC14A ITK ECHDC2 ARAP2	4.24e-05	197	143	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	HIF1A RNF213 USP16 CSNK1D IFI44L SIGLEC1	4.24e-05	197	143	6	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	distal-Hematologic-Proliferating_NK/T-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SMC2 SSTR3 MELK CSNK1E KIF14 ATP2B2	4.36e-05	198	143	6	5c14b152912429f099dfcb6bcb1aec80314a3284
ToppCell	distal-3-Hematologic-Proliferating_NK/T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SMC2 SSTR3 MELK CSNK1E KIF14 ATP2B2	4.36e-05	198	143	6	aa23119d73554733981df474648e59918d04edfc
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PREX2 MAST4 IFI44L ENG NOS3 PKN3	4.36e-05	198	143	6	8a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCell	3'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PREX2 MAST4 IFI44L ENG ATP2B2 PKN3	4.48e-05	199	143	6	0075bcc7d2a5031e76a24cb176e16ac998d846fd
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	KIF1A TNPO2 ABLIM3 CEP170 CSNK1E MAST3	4.61e-05	200	143	6	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	RNF213 SSTR3 CDC14A ITK MAST4 IFI44L	4.61e-05	200	143	6	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	metastatic_Brain-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	HIF1A RNF213 NRP1 CEP170 SIGLEC1 ENG	4.61e-05	200	143	6	bfb54a8ce44caf01083c6567b236395c6ee1d47a
ToppCell	COVID-19-kidney-Mito-rich_Int\|kidney / Disease (COVID-19 only), tissue and cell type	KCNH7 PTPRT MYO18B AGBL1 FBN3	6.06e-05	129	143	5	57b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 MAT1A FAH ECHDC2 DNASE1	1.40e-04	154	143	5	a5289000597068ee8d559f89bce7bce31f35dd57
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	KIF1A HAP1 MAT1A ARFGEF3 DNAH5	1.44e-04	155	143	5	9cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DAB2IP ENG PREX1 NOS3 PKN3	1.44e-04	155	143	5	59035d792c26d870a8b097939e97fa47859ba68c
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	KCNH7 PTPRT SV2C MYO18B AGBL1	1.62e-04	159	143	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARFGEF3 MAST4 DNAH5 AGBL1 FBN3	1.77e-04	162	143	5	5c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCell	Control-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	HIF1A NAB2 CEP170 IFI44L SIGLEC1	2.21e-04	170	143	5	9e328e1f904c77dcce8aee4df775d7f0ac725775
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRDM4 DCUN1D2 USP54 MAST3 DYRK3	2.21e-04	170	143	5	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDC14A PTPRT ADAMTS15 DNAH5 MORN3	2.27e-04	171	143	5	1854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RNF213 CDC14A ITK CRYBG1 ARAP2	2.27e-04	171	143	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAAA ACAA1 SERPINB1 PREX1 MCOLN3	2.34e-04	172	143	5	584af6537685cb459bf0fc298e6f46872016c116
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PREX2 NRP1 MAST4 ENG NOS3	2.40e-04	173	143	5	b0ff9808e38cb64a734ced498cd0546728746cd5
Computational	Response to DNA damage.	MAT1A IARS1 MAT2A SMC2 MELK GRK1 LIG4 CSNK1E MAPKAPK3 KIF14 MAP2K2 DYRK3	7.43e-08	187	94	12	MODULE_244
Drug	magnesium	ACAA1 KIF1A IARS1 MAT2A PEPD DARS1 NUDT9 FAH LIG4 PIK3CA ABCE1 CSNK1D CSNK1E DNAH17 MAPKAPK3 PEX5 SIGLEC1 MAP2K1 MAP2K2 DNAH5 ATP2B2 DNASE1 NOS3 PKN3	2.00e-06	1325	141	24	CID000000888
Disease	Amino Acid Metabolism, Inherited Disorders	MAT1A SLC7A7 D2HGDH	2.95e-05	13	141	3	C0750905
Disease	Amino Acid Metabolism, Inborn Errors	MAT1A SLC7A7 D2HGDH	2.95e-05	13	141	3	C0002514
Disease	limb ischemia (biomarker_via_orthology)	HIF1A NOS3	6.78e-05	3	141	2	DOID:0050852 (biomarker_via_orthology)
Disease	small intestine adenocarcinoma (is_implicated_in)	MAP2K1 MAP2K2	6.78e-05	3	141	2	DOID:4906 (is_implicated_in)
Disease	melancholic depression (implicated_via_orthology)	MORC1 HAP1	1.35e-04	4	141	2	DOID:1595 (implicated_via_orthology)
Disease	Glioblastoma Multiforme	HIF1A FAT1 PIK3CA MAPKAPK3 DYRK2	1.98e-04	111	141	5	C1621958
Disease	Depressive Disorder, Treatment-Resistant	SLC6A2 MAP2K1	2.25e-04	5	141	2	C2063866
Disease	response to bevacizumab, Proteinuria	CAMKMT DNAH5	2.25e-04	5	141	2	EFO_0005943, HP_0000093
Disease	Hyperplasia	HIF1A MAT1A PIK3CA	3.21e-04	28	141	3	C0020507
Disease	Ovarian Mucinous Adenocarcinoma	NRBP1 MAST2 MELK	4.35e-04	31	141	3	C1335167
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1D CSNK1E	4.69e-04	7	141	2	DOID:0060807 (implicated_via_orthology)
Disease	chemotherapy-induced alopecia, methylcobalamin deficiency type cblE	CAMKMT DNAH5	6.23e-04	8	141	2	EFO_0005400, MONDO_0009354
Disease	hepatocellular carcinoma (is_marker_for)	DAB2IP HIF1A SRSF2 PREX2 NRP1 ABCE1 MAP2K2	6.33e-04	301	141	7	DOID:684 (is_marker_for)
Disease	response to selective serotonin reuptake inhibitor	PPP4R3A MAP2K1 AGBL1 PREX1	6.55e-04	82	141	4	EFO_0005658
Disease	lung adenocarcinoma (is_marker_for)	SRSF2 ABCE1 CBX5 MAP2K1	7.49e-04	85	141	4	DOID:3910 (is_marker_for)
Disease	RASopathy (implicated_via_orthology)	MAP2K1 MAP2K2	7.98e-04	9	141	2	DOID:0080690 (implicated_via_orthology)
Disease	bladder neck obstruction (biomarker_via_orthology)	HIF1A NOS3	7.98e-04	9	141	2	DOID:13948 (biomarker_via_orthology)
Disease	Combined immunodeficiency	MAGT1 ITK LIG4	9.97e-04	41	141	3	C0494261
Disease	Cutaneous Melanoma	PIK3CA MAP2K1 MAP2K2	9.97e-04	41	141	3	C0151779
Disease	Noonan Syndrome 1	MAP2K1 MAP2K2	1.21e-03	11	141	2	C4551602
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	PI4KB ATP2B2	1.21e-03	11	141	2	DOID:0050564 (is_implicated_in)
Disease	PEROXISOME BIOGENESIS DISORDER 1A (ZELLWEGER)	PEX16 PEX5	1.21e-03	11	141	2	C4721541
Disease	Turner Syndrome, Male	MAP2K1 MAP2K2	1.21e-03	11	141	2	C0041409
Disease	Female Pseudo-Turner Syndrome	MAP2K1 MAP2K2	1.21e-03	11	141	2	C1527404
Disease	esophagus squamous cell carcinoma (is_implicated_in)	PTPRT AZIN1 FAT1	1.31e-03	45	141	3	DOID:3748 (is_implicated_in)
Disease	Oligospermia	CDC14A NOS3	1.45e-03	12	141	2	C0028960
Disease	response to hydrochlorothiazide, triglyceride measurement	DAB2IP SEC31B AGBL1	1.48e-03	47	141	3	EFO_0004530, EFO_0005202
Disease	liver cirrhosis (implicated_via_orthology)	FAH NOS3	1.71e-03	13	141	2	DOID:5082 (implicated_via_orthology)
Disease	kynurenic acid measurement	SLC7A7 DYRK2	1.71e-03	13	141	2	EFO_0010506
Disease	Infantile Refsum Disease (disorder)	PEX16 PEX5	1.71e-03	13	141	2	C0282527
Disease	Antihypertensive use measurement	MADD EIF1AX METTL15 ATP2B2 PREX1 NOS3	1.77e-03	265	141	6	EFO_0009927
Disease	tetralogy of Fallot (implicated_via_orthology)	DOCK1 DNAH5	1.99e-03	14	141	2	DOID:6419 (implicated_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	DYRK3 DYRK2	2.29e-03	15	141	2	DOID:14250 (implicated_via_orthology)
Disease	MMR-related febrile seizures	IFI44L AGBL1	2.29e-03	15	141	2	EFO_0006519
Disease	Situs ambiguus	PKD1L1 DNAH5	2.29e-03	15	141	2	C0266642
Disease	Peroxisome biogenesis disorders	PEX16 PEX5	2.29e-03	15	141	2	C1832200
Disease	Adrenoleukodystrophy, Neonatal	PEX16 PEX5	2.29e-03	15	141	2	C0282525
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A	2.29e-03	15	141	2	DOID:3146 (implicated_via_orthology)
Disease	chronic lymphocytic leukemia	HAP1 MAST4 MAP2K2 METTL15	2.59e-03	119	141	4	EFO_0000095
Disease	Zellweger Syndrome	PEX16 PEX5	2.60e-03	16	141	2	C0043459
Disease	amygdala volume change measurement	PKD1L1 SPATA31C1	2.60e-03	16	141	2	EFO_0021490
Disease	diabetic retinopathy (implicated_via_orthology)	HIF1A NOS3	2.60e-03	16	141	2	DOID:8947 (implicated_via_orthology)
Disease	colorectal cancer (is_implicated_in)	PTPRT LIG4 FAT1 PIK3CA	2.76e-03	121	141	4	DOID:9256 (is_implicated_in)
Disease	body weight	DOCK1 DIS3L2 INTS12 ANO1 PRDM4 ZZEF1 SPATA31C1 PTPRT MAST4 CDC16 CAMKMT METTL15 NOS3 ARAP1	2.93e-03	1261	141	14	EFO_0004338
Disease	esophageal carcinoma, gastric carcinoma	ATG2B MAST2	2.94e-03	17	141	2	EFO_0000178, EFO_0002916
Disease	cyclic adenosine monophosphate measurement	MAST4 ARAP2	2.94e-03	17	141	2	EFO_0010473
Disease	pre-eclampsia (biomarker_via_orthology)	ENG NOS3	2.94e-03	17	141	2	DOID:10591 (biomarker_via_orthology)
Disease	Noonan-Like Syndrome With Loose Anagen Hair	MAP2K1 MAP2K2	3.68e-03	19	141	2	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	MAP2K1 MAP2K2	3.68e-03	19	141	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	MAP2K1 MAP2K2	3.68e-03	19	141	2	C1275081
Disease	Costello syndrome (disorder)	MAP2K1 MAP2K2	3.68e-03	19	141	2	C0587248
Disease	polycystic kidney disease (biomarker_via_orthology)	HIF1A NOS3	3.68e-03	19	141	2	DOID:0080322 (biomarker_via_orthology)
Disease	obstructive sleep apnea	NRP1 CAMKMT METTL15	3.92e-03	66	141	3	EFO_0003918
Disease	Microcephaly	IARS1 LIG4 KIF14	4.09e-03	67	141	3	C0025958
Disease	waist circumference	NRBP1 PEPD SMARCAD1 PTPRT DNAH5 PREX1 ARAP1	4.67e-03	429	141	7	EFO_0004342

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDTLEEAFEQCAMAM	ZBTB8OS	46	Q8IWT0
AMCAETDAMLGEIIL	ARSK	281	Q6UWY0
EMIFVGRDDCELMLQ	CEP170	21	Q5SW79
MSDEMLERCGYGESL	ABLIM3	336	O94929
CREMSGDLEEGMLAV	ANXA11	411	P50995
IIGATDSCGDLMFLM	CBX5	126	P45973
VDEFVGMLDMLRGDS	BLOC1S4	96	Q9NUP1
RCVFDMAGEIGFTMN	AZIN1	216	O14977
MAAESGELIGACEFM	CDC14A	1	Q9UNH5
DCELDKAVRMGMGAV	ALDH1L2	706	Q3SY69
LETMALLFSGADVMC	ARAP2	826	Q8WZ64
ACADGFEPGLMMTCE	FBN3	2151	Q75N90
RMLSDLVEFCDQMGL	DIS3L2	616	Q8IYB7
EFMDGMTELGCDSIE	DCUN1D1	121	Q96GG9
FCMLEASQDMGRTLE	ENG	181	P17813
GGEFGCTMEELRSLM	ATP2B2	21	Q01814
DMSIGQMEFLECLFP	ATG2B	601	Q96BY7
TCDTLGMADVGTMCD	ADAMTS15	326	Q8TE58
RELEEMGAMFCLGLL	AGBL1	1026	Q96MI9
ICMEHMDGGSLDQVL	MAP2K1	141	Q02750
GEISICMEHMDGGSL	MAP2K2	141	P36507
TIQNGDMCLFDMGGE	PEPD	266	P12955
ILGMDFCGIDLLIMD	RIMKLA	251	Q8IXN7
MFSEECIMDVIGCLE	PPP4R3A	211	Q6IN85
ADDFAMEMGLACVVC	INTS12	151	Q96CB8
ANDECDYGMGLELGM	HPF1	281	Q9NWY4
GLCMIDVVEGTAMDA	PPME1	176	Q9Y570
VLMCGFLPFDDDNVM	MELK	201	Q14680
FMLCFLDDGCGMSPE	MORC1	61	Q86VD1
DFLTDLMMSEVDRCG	DAB2IP	391	Q5VWQ8
VSGGNEDSCFMIDME	FAT1	756	Q14517
EEFMDAVCDGVGLGM	KIF14	1411	Q15058
SFGMCALEMAVLEIQ	NRBP2	241	Q9NSY0
DAFLDAVMLEREGMG	MADD	1326	Q8WXG6
LGMVLLCEAATSDMD	MAGT1	281	Q9H0U3
IIMECMEGGELFSRI	MAPKAPK3	116	Q16644
CDYGMGLELGMDLFC	nan	286	A8MVJ9
MVSECLFSLINGDDM	MCOLN3	446	Q8TDD5
VMALAGLAMGCIDTV	MFSD4A	111	Q8N468
SEAMGISGDMCTFEA	MTMR8	631	Q96EF0
TGEIRGMCDFMNLSL	NAAA	96	Q02083
GEEEFLEIMALVGMA	NAB2	76	Q15742
DGFCEMTGFSRPDVM	KCNH7	46	Q9NS40
LDGFVMVLTDDGDMI	HIF1A	96	Q16665
GLMFGYATDETEECM	MAT2A	136	P31153
LPFMLCDTMGLDGAE	IFI44L	256	Q53G44
EVDIASGMAIEGMCY	ECHDC2	251	Q86YB7
EFLDGMTELGCDSME	DCUN1D2	121	Q6PH85
TGEIMDNLMLEAGDD	NUDT9	291	Q9BW91
MAMRELVEAECGGAN	PEX5	1	P50542
CGAEGDYNVMVMELL	CSNK1D	71	P48730
FVGMESGILLCMAFD	OR56B1	116	Q8NGI3
MELGEVICKCMGEAD	HEATR6	711	Q6AI08
EGIKMAMVACGDAFT	NEK8	611	Q86SG6
LGGDFEFMDDANMCI	LAPTM4B	151	Q86VI4
GLMFGYATDETEECM	MAT1A	136	Q00266
DCLPEFIGRGMAMAS	LRP2BP	286	Q9P2M1
LGAMVKGMGESCFED	GCN1	1681	Q92616
GTFDGVLMDLGCSSM	METTL15P1	161	P0C7V9
FRMEECAPGGCLMEL	ANO1	646	Q5XXA6
GTFDGVLMDLGCSSM	METTL15	161	A6NJ78
SMGDRDMGLFLSLIE	ODAD1	401	Q96M63
EIGFAIGMPVCEFDM	PIK3CA	116	P42336
SFGMCALEMAVLEIQ	NRBP1	261	Q9UHY1
LERGHMFVCGDVTMA	NOS3	1106	P29474
TGCFIAIDTMLDMAE	PTPRT	1091	O14522
EDFKCMEALGMESGE	NRP1	271	O14786
AGEFTDSEIMVMLGE	ABCE1	366	P61221
VTMLGHCIEMYIGDS	CDC16	516	Q13042
VQMDQAGMCGDIFES	ATMIN	506	O43313
MGRDSELIGNFVACM	DOCK1	921	Q14185
ADIQICILDGEMMAY	LIG4	321	P49917
DFELICEIMLMAEGF	DNAH17	1976	Q9UFH2
GLEDVMLMGDFNAGC	DNASE1	181	P24855
LCMEAILSVGLEMGS	ARFGEF3	991	Q5TH69
GLMLAADIMRGEDFT	HAP1	541	P54257
MCLDPDGNSLFDSMA	DGCR2	331	P98153
CGIRGSEMFAEMDLR	LYG2	61	Q86SG7
CMVMEYVEGGDCATL	MAST2	586	Q6P0Q8
CMVMEYVEGGDCATL	MAST3	441	O60307
VMEYVEGGDCATLMK	MAST4	646	O15021
RGEMADFGAMGCVDI	KCMF1	341	Q9P0J7
DFGAMGCVDIMPLDV	KCMF1	346	Q9P0J7
DCIIVGGMDMVAQAL	DDX49	101	Q9Y6V7
IEIMMEGCEYAISNA	EXOC1	171	Q9NV70
ATAGIATFCMLMPEE	SERPINB1	336	P30740
GACKLLDMELEMAFF	FAH	191	P16930
ETGMCSFVMEGGETE	CRYBG1	1236	Q9Y4K1
ADLCLVMTIMNGGDI	GRK1	261	Q15835
DEGDQLACMIELLGM	DYRK2	426	Q92630
SGEALCLMMDFGDSS	PKD1L1	316	Q8TDX9
GEDEGDQLACMMELL	DYRK3	411	O43781
GMLGEILSAFEFMDA	D2HGDH	301	Q8N465
NCHLGLDFMDELMDI	DNAH5	4101	Q8TE73
EALLAEMGVAMREDG	KIF1A	466	Q12756
NMAKCGTMIDFGRDE	MORN3	191	Q6PF18
TDGMAEELTMDGVAG	PRDM4	206	Q9UKN5
CFVTEFVPGGDLMMQ	PKN3	636	Q6P5Z2
AETLLGMCLDVCEGM	ITK	456	Q08881
GMCLDVCEGMAYLEE	ITK	461	Q08881
TDGMEMLLCYEDEGV	MINK1	1221	Q8N4C8
DCLGIGMMLTFNAEA	NRK	1466	Q7Z2Y5
LSVLECVEVFMEMGA	PEX16	86	Q9Y5Y5
GMCKSVFVMEAGEAA	FAN1	791	Q9Y2M0
MGGMEAVITGLADDF	SLC6A2	421	P23975
CLGLSSMFGNMEGVV	SLC6A19	426	Q695T7
AMDAMDGAVLDGREL	SRSF2	71	Q01130
MACGVESMSLADRGN	ACAA1	146	P09110
FVLGMALMADGVEVF	SV2C	156	Q496J9
TMDGAIAAALLMFGD	SMARCAD1	186	Q9H4L7
FGSLMCRLVMAVDGI	SSTR3	111	P32745
EFEDALCALMVMAAP	LARS2	776	Q15031
AMGEEIGAEMALRTF	PSMD2	661	Q13200
DEMGSGDELPCDMRI	PREX1	1196	Q8TCU6
ALAMLREAGVEMGDE	DARS1	351	P14868
NGMEDCVMALETLFS	IARS1	746	P41252
ELCDMLGTRMEQEGS	SEC31B	661	Q9NQW1
CLMEEAVSEFEPGMA	SPATA31C1	856	P0DKV0
TTEFVDVMGGLDGDM	PI4KB	711	Q9UBF8
FTIADPDDRGMLDMC	RO60	506	P10155
MLDMCGFDTGALDVI	RO60	516	P10155
VTMLLECGMQEEGLF	ARHGAP44	276	Q17R89
MEQLLGCSDEGEAMT	TBC1D9B	711	Q66K14
TECQGLSDTRLMDMG	ARAP1	36	Q96P48
GMTCLAGLMVAISAD	CAMKMT	156	Q7Z624
MASASEGEMECGQEL	RNF213	41	Q63HN8
LAGCEMTLDAFAAMA	RNF213	3851	Q63HN8
LEGDMMCALLNSISD	ZNF451	1006	Q9Y4E5
GMLCAGFMEGKIDAC	TMPRSS11F	371	Q6ZWK6
DRIFGGELTSMIMCD	USP16	356	Q9Y5T5
TDTMLCAGFMSGEAD	TMPRSS11B	346	Q86T26
LEAVLAAMGMGDAFS	SERPINB13	296	Q9UIV8
GEDGVSQMALEDLAM	TKTL2	426	Q9H0I9
EKDSAFRGICMMIGV	TNPO2	816	O14787
LCMSVAAEMDLEDGG	SLC7A7	486	Q9UM01
EHLCFMGSGREEEDM	TBC1D23	396	Q9NUY8
EAMIFGVGLCDNGFM	PREX2	531	Q70Z35
DMGQGHMALFICTVD	SIGLEC1	806	Q9BZZ2
EDGAEATLAGQMMAC	SMC2	391	O95347
KMTGVDCVEGMASGL	MYO18B	901	Q8IUG5
MGPLTFMDVAIEFCL	ZNF43	1	P17038
MAEIHNGGELCDFME	ZNF121	1	P58317
TTVEALMMGEPFFDC	VPS13B	431	Q7Z7G8
LGTMALAACQFMEEP	ZZEF1	2681	O43149
DVMLENFAVMASLGC	ZNF530	41	Q6P9A1
GIMDDAAECFENLLM	USP54	116	Q70EL1
MLGNGRLEAMCFDGV	EIF1AX	41	P47813
CGAEGDYNVMVMELL	CSNK1E	71	P49674