Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

KLHL10 KLHL36 KLHL4

3.43e-05274432.130.10.80
DomainGal_Oxidase_b-propeller

KLHL10 KLHL36 KLHL4

6.94e-0534443IPR015916
DomainKelch

KLHL10 KLHL36 KLHL4

3.44e-0458443SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL10 KLHL36 KLHL4

3.62e-0459443IPR011043
DomainBACK

KLHL10 KLHL36 KLHL4

3.80e-0460443SM00875
DomainBACK

KLHL10 KLHL36 KLHL4

3.99e-0461443PF07707
DomainBACK

KLHL10 KLHL36 KLHL4

3.99e-0461443IPR011705
DomainKelch_1

KLHL10 KLHL36 KLHL4

5.98e-0470443PF01344
DomainKelch_1

KLHL10 KLHL36 KLHL4

5.98e-0470443IPR006652
DomainBTB

KLHL10 KLHL36 KLHL4

3.62e-03131443PF00651
DomainBTB-kelch_protein

KLHL10 KLHL36

4.61e-0343442IPR017096
DomainBTB

KLHL10 KLHL36 KLHL4

6.32e-03160443PS50097
DomainBTB

KLHL10 KLHL36 KLHL4

8.73e-03180443SM00225
Pubmed

Potential Role of CD133 Expression in the Susceptibility of Human Liver Cancer Stem-Like Cells to TRAIL.

PROM1 TNFSF10

1.56e-06244228281970
Pubmed

Update on the Kelch-like (KLHL) gene family.

KLHL10 KLHL36 KLHL4

1.95e-054144323676014
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DENND6B OAT SMPD3 HUWE1 PALS2 CORO2A CREBBP HCN1 KLHL4

2.75e-05128544935914814
Pubmed

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.

HUWE1 CREBBP

4.36e-05844227934968
Pubmed

Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

MYO3A SLC26A5

5.60e-05944219339464
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

DENND6B HUWE1 DNAH5 CORO2A CREBBP

6.15e-0533244537433992
Pubmed

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.

TNFSF10 CREBBP

6.99e-051044215619633
Pubmed

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.

PROM1 DNAH5

1.21e-041344235942101
Pubmed

Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells.

PROM1 CREBBP

1.41e-041444223308088
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

DNAJA3 OAT HUWE1 GTF3C2

1.48e-0421144417314511
Pubmed

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.

DNAH5 KLHL36 KLHL4

1.86e-048744337495603
Pubmed

Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.

TLR4 SMAD9

2.10e-041744227606421
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

HCN1 TRPC3

3.24e-042144230270038
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

DNAJA3 OAT CAMKK2 UFSP2 PALS2

3.55e-0448444531995728
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DNAJA3 OAT EEF2K CAMKK2 GTF3C2 NDUFAF2 SLC33A1 SUPT6H

4.91e-04148744833957083
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

MYO3A RAB28 MMD CREBBP ANKAR TLR4

5.34e-0481444623251661
Pubmed

Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.

PROM1 SMAD9

9.06e-043544218676816
Cytoband2q33.1

RFTN2 PGAP1

1.11e-03514422q33.1
GeneFamilyKelch like|BTB domain containing

KLHL10 KLHL36 KLHL4

6.63e-0542343617
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL10 KLHL36 KLHL4

2.01e-03134343861
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC9 SMPD3 TNFSF10 PARP8 KLHL4

1.38e-06195445df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 KLHL10 DNAH5 TENM2

1.78e-05158444f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 KLHL10 DNAH5 TENM2

1.78e-051584448c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellTCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-7|TCGA-Cervix / Sample_Type by Project: Shred V9

PROM1 ANO5 SMPD3 LGALS4

1.83e-0515944475a82bbabd97b168dbf1c3f43a9bdad48ce18c78
ToppCellfacs-Large_Intestine-Proximal|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PROM1 CORO2A MMD

2.27e-0516844423e0e1592d7400012d289adb10c7598285bae2e9
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PROM1 CORO2A MMD

2.54e-05173444e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 PROM1 CORO2A MMD

2.54e-0517344499532bb768ee35fed939a377acb5215d3f8904bd
ToppCellP15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PHLDB3 TTC9 ANKAR KLHL4

2.66e-0517544484d252f3e432231687613299bbea14978bb4b06b
ToppCellP15-Endothelial-lymphatic_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PHLDB3 TTC9 ANKAR KLHL4

2.66e-05175444a00c6fa9b33640710dd05a3799031147196f0986
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TTC9 TRPC3 SLC26A5 KLHL4

2.72e-05176444460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCellEndothelial-Endothelial-C|Endothelial / shred on cell class and cell subclass (v4)

PCSK5 KLHL36 PARP8 SLC45A4

2.78e-05177444b5b9278dfd76b1aacd88e5fe86e91a2c9b565f87
ToppCellfacs-Heart-LA-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC9 TNFSF10 SLC45A4 KLHL4

3.30e-051854441ecfca049c0c1110fd1b2256db7cb7abda6afb04
ToppCellfacs-Heart-LA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC9 TNFSF10 SLC45A4 KLHL4

3.30e-05185444b6df1412b579d40ed5df806f9c54bd1fbb9a1e15
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 MYO3A PALS2 TNFSF10

3.37e-05186444f28d72b47624b69a580b4429e2be560a26898591
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 TNFSF10 SLC45A4 SMAD9

3.37e-051864443dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 MYO3A PALS2 TNFSF10

3.59e-051894443b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PROM1 MYO3A PALS2 TNFSF10

3.74e-051914441cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC9 TNFSF10 PARP8 KLHL4

3.98e-05194444c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYO3A DNAH5 VPS13C SLC26A5

4.22e-05197444b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell3'-GW_trimst-1-SmallIntestine|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 OAT TNFSF10 CORO2A

4.39e-05199444c4a1e0cf3be867e7cebbd8bd3668bc2df391671b
Diseasehearing impairment

MYO3A SLC33A1 TLR4 SLC26A5

1.40e-0598444C1384666
DiseaseStargardt's disease

PROM1 ITIH2

3.25e-056442C0271093
Diseaseschizophrenia, intelligence, self reported educational attainment

DENND6B SMPD3 PALS2 NDUFAF2 HCN1

1.61e-04346445EFO_0004337, EFO_0004784, MONDO_0005090
DiseaseLung diseases

PCSK5 DNAH5 SMAD9

2.18e-0478443C0024115
DiseaseNecrotizing Enterocolitis

OAT TLR4

2.91e-0417442C0520459
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

PCSK5 DNAH5

3.66e-0419442DOID:9562 (implicated_via_orthology)
Diseaseamblyopia

PARP8 TLR4

4.93e-0422442MONDO_0001020
DiseaseColorectal Carcinoma

PROM1 TNFSF10 SLC33A1 PARP8 TLR4 SMAD9

5.80e-04702446C0009402
Diseaseneuroblastoma

DNAH5 TENM2 PARP8

6.97e-04116443EFO_0000621
Diseasetriacylglycerol 50:1 measurement

PCSK5 GTF3C2

7.45e-0427442EFO_0010408
DiseaseColorectal Neoplasms

PROM1 TNFSF10 TLR4 SMAD9

7.68e-04277444C0009404
DiseaseCone-Rod Dystrophy 2

PROM1 RAB28

8.60e-0429442C3489532
Diseasearteriosclerosis (is_implicated_in)

TNFSF10 TLR4

9.83e-0431442DOID:2349 (is_implicated_in)
Diseaseovarian neoplasm

CAMKK2 TNFSF10 TLR4

1.06e-03134443C0919267
DiseaseMalignant neoplasm of ovary

CAMKK2 TNFSF10 TLR4

1.13e-03137443C1140680
Diseasechronic kidney disease, diabetic nephropathy

PROM1 TENM2

1.33e-0336442EFO_0000401, EFO_0003884
Diseasevisceral heterotaxy (implicated_via_orthology)

PCSK5 DNAH5

1.40e-0337442DOID:0050545 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EHQGGFPIYYYIVVL

SLC33A1

401

O00400
LIKNYYGEKIGIYFV

ANO5

291

Q75V66
GYLEYVKKLGYVTGH

CREBBP

1456

Q92793
EPAHYFGYVYFRQVK

DENND6B

126

Q8NEG7
KYIYGAQGVLLVYDI

RAB28

81

P51157
VENYYLKGYIVGAIH

RFTN2

66

Q52LD8
HYKVVVNGNPFYEYG

LGALS4

111

P56470
EFHGKSYYVIYFELE

ANKAR

431

Q7Z5J8
GVIYFQAIEEVYYDH

PHLDB3

576

Q6NSJ2
FYYGGQVNYDGELHK

PARP8

136

Q8N3A8
IYKDFVYISGGHDYQ

KLHL36

441

Q8N4N3
FIDGHYKDYFVPQLY

ITIH2

926

P19823
NIGQIGALKDYYHFY

PCSK5

61

Q92824
EQLHGYFEYILYDVG

SMPD3

376

Q9NY59
YHFYQGLVYLLENDV

HUWE1

4151

Q7Z6Z7
KLYVVGGYDGHTYLN

KLHL4

671

Q9C0H6
AAGGTIYVFLYHEKY

MMD

136

Q15546
VDLIYFYHVGKVYCG

PRICKLE3

226

O43900
AGKYLEHGEYEGNLY

PALS2

401

Q9NZW5
IHDYYEHRYQGKIFD

HCN1

431

O60741
YHGAAYLKGYVYIIG

KLHL10

331

Q6JEL2
YVVGKGDGNIRYYEV

CORO2A

286

Q92828
FYFQDLIKGIEYLHY

CAMKK2

291

Q96RR4
FHLEHYIEGKYIKYN

EEF2K

226

O00418
INSYGYGDHYIHIKI

DNAJA3

396

Q96EY1
FIQGYKFIYGEKHVE

DNAH5

3181

Q8TE73
AGIVKEYGDVGIYVY

SLC26A5

661

P58743
KYGRTIIGYFEHYLQ

PROM1

741

O43490
VEHFGKFGVIYYDIN

TENM2

2126

Q9NT68
LYLYGEGSYAEEHKI

PGAP1

66

Q75T13
GEYEEYITKLFNYHK

OAT

121

P04181
VHLYYVGGEVYAECV

SMAD9

336

O15198
GMIYVVQGIYGYHHY

UFSP2

276

Q9NUQ7
YALLGQYHDIKQYIH

SLC45A4

636

Q5BKX6
KDVYNHFLLYYGRDI

SUPT6H

461

Q7KZ85
EHVGTDQFGNKYYYI

NDUFAF2

21

Q8N183
HSGEFIYGLENFVYK

VPS13C

131

Q709C8
IHYIDAGYLGFKAYF

GTF3C2

686

Q8WUA4
FCYLGHYYRDVVGDK

TTC37

496

Q6PGP7
NGELVIHEKGFYYIY

TNFSF10

171

P50591
KYGRGENIYDAFVIY

TLR4

666

O00206
YDHKFIENIGYVLYG

TRPC3

626

Q13507
GVAFYHLGDYDKALY

TTC9

171

Q92623
GYTQFYYVDVLDGKL

MUC12

5311

Q9UKN1
IGEKNFHIFYYIYAG

MYO3A

521

Q8NEV4