Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

NFIB MYOD1 GLI2 GATA3 GLIS3 IRX3 ZIC2 TLX2

4.36e-05560478GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

NFIB MYOD1 GLI2 GATA3 GLIS3 IRX3 ZIC2 TLX2

4.71e-05566478GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZIC5 NFIB MYOD1 GLI2 GATA3 SP6 GLIS3 IRX3 IRX1 ZIC2 TLX2

1.14e-0412444711GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZIC5 NFIB MYOD1 GLI2 GATA3 SP6 GLIS3 IRX3 IRX1 ZIC2 TLX2

1.38e-0412714711GO:0000987
GeneOntologyMolecularFunctionzinc ion binding

ZCCHC14 UBR5 GLI2 GATA3 HRG MARCHF4 NBR1 SF3A2 RBM20

1.99e-04891479GO:0008270
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZIC5 NFIB MYOD1 GLI2 GATA3 SP6 GLIS3 IRX3 IRX1 ZIC2 TLX2

3.46e-0414124711GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZIC5 NFIB MYOD1 GLI2 GATA3 SP6 GLIS3 IRX3 IRX1 ZIC2 TLX2

4.58e-0414594711GO:0000977
GeneOntologyMolecularFunctiontransition metal ion binding

ZCCHC14 UBR5 GLI2 GATA3 HRG MARCHF4 NBR1 SF3A2 RBM20

1.60e-031189479GO:0046914
GeneOntologyMolecularFunctiontransforming growth factor beta binding

VASN LTBP4

1.70e-0326472GO:0050431
GeneOntologyBiologicalProcesstube formation

ZIC5 NFIB GATA3 IRX3 IRX1 ZIC2

4.04e-06187476GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

ZIC5 GLI2 GATA3 IRX3 IRX1 ZIC2

4.43e-06190476GO:0016331
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

ZIC5 TJP1 NFIB MYOD1 GLI2 GATA3 HRG IRX3 IRX1 TERT RBM20 ZIC2 TLX2

1.81e-0514834713GO:0048646
GeneOntologyBiologicalProcessnephron tubule formation

GATA3 IRX3 IRX1

1.90e-0523473GO:0072079
GeneOntologyBiologicalProcessembryonic epithelial tube formation

ZIC5 GATA3 IRX3 IRX1 ZIC2

3.02e-05159475GO:0001838
GeneOntologyBiologicalProcessspecification of loop of Henle identity

IRX3 IRX1

3.04e-054472GO:0072086
GeneOntologyBiologicalProcessepithelial tube formation

ZIC5 GATA3 IRX3 IRX1 ZIC2

4.52e-05173475GO:0072175
GeneOntologyBiologicalProcessspecification of nephron tubule identity

IRX3 IRX1

5.06e-055472GO:0072081
GeneOntologyBiologicalProcessproximal/distal pattern formation involved in nephron development

IRX3 IRX1

5.06e-055472GO:0072047
GeneOntologyBiologicalProcessproximal/distal pattern formation

GLI2 IRX3 IRX1

8.16e-0537473GO:0009954
GeneOntologyBiologicalProcessnegative regulation of smoothened signaling pathway

UBR5 GLI2 KIF7

1.20e-0442473GO:0045879
GeneOntologyBiologicalProcesspattern specification involved in kidney development

IRX3 IRX1

1.41e-048472GO:0061004
GeneOntologyBiologicalProcessrenal system pattern specification

IRX3 IRX1

1.41e-048472GO:0072048
GeneOntologyBiologicalProcesstube morphogenesis

ZIC5 TJP1 NFIB GLI2 GATA3 HRG IRX3 IRX1 TERT ZIC2

1.83e-0411254710GO:0035239
GeneOntologyBiologicalProcessloop of Henle development

IRX3 IRX1

2.26e-0410472GO:0072070
GeneOntologyBiologicalProcessepithelial tube morphogenesis

ZIC5 GLI2 GATA3 IRX3 IRX1 ZIC2

3.69e-04421476GO:0060562
GeneOntologyBiologicalProcessmesenchymal cell differentiation

ZIC5 VASN GATA3 SP6 ZIC2

5.51e-04296475GO:0048762
MousePhenoabnormal incisor morphology

ZIC5 GLI2 GATA3 SP6 IRX1

1.12e-05110385MP:0005358
MousePhenosmall incisors

GATA3 SP6 IRX1

2.75e-0522383MP:0030079
MousePhenomicrodontia

GATA3 SP6 IRX1

4.61e-0526383MP:0030088
MousePhenoabnormal lung size

NFIB GLI2 IRX1 LTBP4 KIF7

1.02e-04174385MP:0004881
MousePhenoabnormal R wave

IRX3 RBM20

1.50e-047382MP:0011919
MousePhenoabnormal temporomandibular joint morphology

GLI2 GATA3

1.99e-048382MP:0011210
MousePhenosmall lung saccule

NFIB GLI2

1.99e-048382MP:0010827
MousePhenosmall lung

NFIB GLI2 IRX1 KIF7

2.59e-04115384MP:0003641
DomainIRO

IRX3 IRX1

9.24e-056472SM00548
DomainIroquois_homeo

IRX3 IRX1

9.24e-056472IPR003893
DomainZnf_C2H2_matrin

SF3A2 RBM20

4.03e-0412472IPR000690
DomainZnf_C2H2-like

ZIC5 GLI2 SP6 GLIS3 FBXO41 GPATCH8 SF3A2 ZIC2

7.55e-04796478IPR015880
DomainZnf_C2H2

ZIC5 GLI2 SP6 GLIS3 FBXO41 GPATCH8 SF3A2 ZIC2

8.13e-04805478IPR007087
DomainHomeobox_KN

IRX3 IRX1

8.23e-0417472PF05920
DomainHomeobox_KN_domain

IRX3 IRX1

8.23e-0417472IPR008422
DomainZnF_C2H2

ZIC5 GLI2 SP6 GLIS3 FBXO41 GPATCH8 SF3A2 ZIC2

8.33e-04808478SM00355
DomainZF_MATRIN

SF3A2 RBM20

9.24e-0418472PS50171
DomainZnF_U1

SF3A2 RBM20

2.41e-0329472SM00451
DomainZnf_U1

SF3A2 RBM20

2.41e-0329472IPR003604
Domainzf-C2H2

ZIC5 GLI2 SP6 GLIS3 FBXO41 ZIC2

7.51e-03693476PF00096
DomainHomeobox_CS

IRX3 IRX1 TLX2

1.14e-02186473IPR017970
DomainZINC_FINGER_C2H2_2

ZIC5 GLI2 SP6 GLIS3 GPATCH8 ZIC2

1.26e-02775476PS50157
DomainZINC_FINGER_C2H2_1

ZIC5 GLI2 SP6 GLIS3 GPATCH8 ZIC2

1.28e-02777476PS00028
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

UBR5 ZIC5 GATA3 ZIC2

2.56e-04153294M39546
PathwayKEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY

GLI2 KIF7

3.66e-0414292M47414
PathwayWP_HEDGEHOG_SIGNALING_WP47

GLI2 KIF7

4.82e-0416292M39675
Pubmed

CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.

ZIC5 GLI2 GLIS3 ZIC2

7.25e-101049418298960
Pubmed

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.

GLI2 GATA3 IRX1 ZIC2

6.25e-091649417638910
Pubmed

A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.

MYOD1 GLI2 ZIC2

3.13e-071049321211521
Pubmed

Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways.

GATA3 IRX1 ZIC2

5.73e-071249316354917
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

ZIC5 NFIB MYOD1 GLI2 GATA3 IRX3 IRX1 TLX2

8.74e-0754449828473536
Pubmed

Description of the smallest critical region for Dandy-Walker malformation in chromosome 13 in a girl with a cryptic deletion related to t(6;13)(q23;q32).

ZIC5 ZIC2

1.94e-06249220683983
Pubmed

A census of human transcription factors: function, expression and evolution.

NFIB MYOD1 GLI2 GATA3 SP6 IRX3 IRX1 ZIC2 TLX2

4.36e-0690849919274049
Pubmed

Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse.

TJP1 GLI2 ZIC2

5.21e-062449336916392
Pubmed

Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.

IRX3 IRX1

5.83e-0634929486539
Pubmed

The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.

IRX3 IRX1

5.83e-06349235328612
Pubmed

Expression of ZIC family genes in meningiomas and other brain tumors.

ZIC5 ZIC2

5.83e-06349220199689
Pubmed

Epigenetic Alteration by DNA Methylation of ESR1, MYOD1 and hTERT Gene Promoters is Useful for Prediction of Response in Patients of Locally Advanced Invasive Cervical Carcinoma Treated by Chemoradiation.

MYOD1 TERT

5.83e-06349226344356
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

KRBA1 UBR5 TJP1 SEC16A NBR1

6.20e-0618449532908313
Pubmed

Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).

GATA3 IRX3 IRX1

1.15e-053149329459093
Pubmed

SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.

ZIC5 ZIC2

1.16e-05449234638777
Pubmed

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.

GLI2 KIF7

1.16e-05449224952464
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZCCHC14 KRBA1 ZIC5 NFIB MYOD1 GATA3 GLIS3 TERT

1.59e-0580849820412781
Pubmed

HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.

UBR5 TERT

1.94e-05549223612978
Pubmed

Iroquois genes influence proximo-distal morphogenesis during rat lung development.

IRX3 IRX1

1.94e-05549216299054
Pubmed

NFIB regulates embryonic development of submandibular glands.

TJP1 NFIB

1.94e-05549225403566
Pubmed

Expression of two novel mouse Iroquois homeobox genes during neurogenesis.

IRX3 IRX1

1.94e-05549210704856
Pubmed

Expression pattern of Irx1 and Irx2 during mouse digit development.

GLI2 IRX1

1.94e-05549211472848
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZCCHC14 UBR5 PLEKHM2 SEC16A GPATCH8 MARCHF4

2.26e-0540749612693553
Pubmed

Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.

TJP1 GLI2 SP6

2.50e-054049317199044
Pubmed

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.

TJP1 IRX3 IRX1

2.50e-054049323362348
Pubmed

Epiprofin/Sp6 regulates Wnt-BMP signaling and the establishment of cellular junctions during the bell stage of tooth development.

TJP1 SP6

2.91e-05649222868911
Pubmed

Physical and functional interactions between Zic and Gli proteins.

GLI2 ZIC2

2.91e-05649211238441
Pubmed

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos.

IRX3 IRX1

2.91e-05649220408909
Pubmed

Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.

UBR5 TERT

2.91e-05649223362280
Pubmed

Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression.

IRX3 IRX1

2.91e-05649236773339
Pubmed

Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development.

IRX3 IRX1

2.91e-05649211042145
Pubmed

Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.

ZIC5 ZIC2

2.91e-05649215465018
Pubmed

Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.

IRX3 IRX1

2.91e-05649210370142
Pubmed

Irx1 and Irx2 expression in early lung development.

GLI2 IRX1

2.91e-05649211472847
Pubmed

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.

ZIC5 ZIC2

4.07e-05749225233373
Pubmed

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.

GLI2 KIF7

4.07e-05749225644602
Pubmed

The prepattern transcription factor Irx3 directs nephron segment identity.

IRX3 IRX1

4.07e-05749217875669
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NFIB SEC16A GLIS3 GPATCH8 MAGT1 RBM20

4.32e-0545749632344865
Pubmed

The emergent landscape of the mouse gut endoderm at single-cell resolution.

GATA3 IRX3 IRX1

4.35e-054849330959515
Pubmed

Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol.

IRX3 IRX1

5.42e-05849211118473
Pubmed

Identification of a novel mouse Iroquois homeobox gene, Irx5, and chromosomal localisation of all members of the mouse Iroquois gene family.

IRX3 IRX1

5.42e-05849210822268
Pubmed

The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.

IRX3 IRX1

6.96e-05949214585979
Pubmed

Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons.

GLI2 ZIC2

6.96e-05949218832395
Pubmed

Gene and cluster-specific expression of the Iroquois family members during mouse development.

IRX3 IRX1

6.96e-05949211520674
Pubmed

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

GLI2 KIF7

8.69e-051049219549984
Pubmed

Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.

ZIC5 ZIC2

8.69e-051049215136147
Pubmed

PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.

TJP1 PCSK7

8.69e-051049226416966
Pubmed

Spatiotemporal expression of Zic genes during vertebrate inner ear development.

ZIC5 ZIC2

8.69e-051049223606270
Pubmed

Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.

GLI2 KIF7

8.69e-051049223166838
Pubmed

Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.

ZIC5 ZIC2

8.69e-051049215736266
Pubmed

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure.

TJP1 GLI2

1.06e-041149233103996
Pubmed

Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.

IRX3 IRX1

1.06e-041149210926765
Pubmed

Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis.

TJP1 MYOD1

1.06e-041149226839363
Pubmed

Retinal pigment epithelial integrity is compromised in the developing albino mouse retina.

TJP1 ZIC2

1.27e-041249227097562
Pubmed

A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.

TJP1 GATA3

1.50e-041349226859289
Pubmed

Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication.

MYOD1 ZIC2

1.50e-041349211455436
Pubmed

Human transcription factor protein interaction networks.

NFIB MYOD1 GLI2 SEC16A GATA3 GPATCH8 RBM20 KIF7 TLX2

1.51e-04142949935140242
Pubmed

The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.

GLI2 SP6 IRX3 IRX1

1.54e-0419149424146773
Pubmed

GLI3 repressor controls functional development of the mouse ureter.

GLI2 UPK3B

1.75e-041449221339645
Pubmed

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.

GLI2 KIF7

1.75e-041449219666503
Pubmed

Sufu and Kif7 in limb patterning and development.

GLI2 KIF7

1.75e-041449225581370
Pubmed

Cilia-dependent GLI processing in neural crest cells is required for tongue development.

MYOD1 GLI2

1.75e-041449228286175
Pubmed

Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity.

GATA3 IRX3

1.75e-041449219666821
Pubmed

Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors.

TJP1 MYOD1

2.02e-041549220059958
Pubmed

Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.

MYOD1 GLI2

2.02e-041549215604102
Pubmed

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.

GLI2 KIF7

2.02e-041549226439735
Pubmed

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.

GLI2 KIF7

2.30e-041649223034632
Pubmed

Gli2 and Gli3 play distinct roles in the dorsoventral patterning of the mouse hindbrain.

GLI2 IRX3

2.30e-041649217026983
Pubmed

Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.

TJP1 MYOD1

2.30e-041649224927569
Pubmed

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.

GLI2 IRX3

2.30e-041649224726283
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

UBR5 ZIC5 HRG GPATCH8 ZIC2

2.36e-0439649526687479
Pubmed

Coordinated regulation of gene expression by Brn3a in developing sensory ganglia.

GATA3 IRX1

2.61e-041749215253936
Pubmed

Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.

IRX3 KIF7

2.61e-041749224726282
Pubmed

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.

UBR5 TJP1 RANBP3 NBR1

2.92e-0422649431452512
Pubmed

Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates.

IRX3 IRX1

2.93e-041849224528677
Pubmed

Wnt/β-catenin promotes gastric fundus specification in mice and humans.

IRX3 IRX1

2.93e-041849228052057
Pubmed

PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors.

GATA3 IRX3

3.27e-041949224115909
Pubmed

Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.

ZIC5 ZIC2

3.27e-041949215799026
Pubmed

Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.

MYOD1 GLI2

3.27e-041949225848030
Pubmed

FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.

TJP1 IRX3

3.27e-041949223616926
Pubmed

Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop.

GATA3 IRX3

3.64e-042049221338882
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

UBR5 TJP1 NHSL2 SEC16A FBXO41 ZIC2 KIF7

3.80e-0496349728671696
Pubmed

Three-dimensional molecular architecture of mouse organogenesis.

GATA3 IRX3 ZIC2

3.86e-0410049337524711
Pubmed

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis.

GATA3 IRX3

4.01e-042149217922007
Pubmed

Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

GLI2 KIF7

4.01e-042149223650387
Pubmed

A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation.

IRX3 IRX1

4.01e-042149228760814
Pubmed

A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.

NFIB IRX3 IRX1

4.09e-0410249319741146
Pubmed

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord.

GLI2 GATA3

4.41e-042249215215207
Pubmed

Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.

IRX3 IRX1

4.41e-042249215789444
Pubmed

Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.

MYOD1 GLI2

4.41e-042249225224227
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

TJP1 RANBP3 SEC16A NBR1

4.68e-0425649433397691
Pubmed

Role of β-catenin in development of bile ducts.

TJP1 GLIS3

4.83e-042349226856660
Pubmed

Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity.

MYOD1 GLI2

4.83e-042349222987640
Pubmed

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

RANBP3 TMEM51 GLIS3

5.10e-0411049337219487
Pubmed

Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.

GATA3 IRX3

5.26e-042449214534138
Pubmed

Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization.

TJP1 GLI2

5.26e-042449212403705
Pubmed

Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner.

GLI2 IRX3

5.71e-042549218927156
Pubmed

Holoprosencephaly Overview

GLI2 ZIC2

5.71e-042549220301702
Pubmed

Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.

TJP1 GATA3

5.71e-042549219389377
Pubmed

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.

UBR5 TJP1 SLC4A3

5.96e-0411649330652415
InteractionTLE3 interactions

UBR5 NFIB MYOD1 GLI2 GATA3 GPATCH8 RBM20 TLX2

2.68e-06376488int:TLE3
InteractionDPF1 interactions

NFIB MYOD1 GATA3 STK11IP TLX2

3.05e-0695485int:DPF1
InteractionMIDEAS interactions

NFIB MYOD1 SEC16A GATA3 TLX2

5.74e-06108485int:MIDEAS
InteractionDPF2 interactions

NFIB MYOD1 GATA3 GPATCH8 STK11IP NBR1 TLX2

1.76e-05349487int:DPF2
InteractionCIB1 interactions

UBR5 GLIS3 TERT NBR1

2.19e-0569484int:CIB1
InteractionKDM2B interactions

NFIB MYOD1 GLI2 GATA3 TLX2

3.97e-05161485int:KDM2B
InteractionBCL9 interactions

NFIB MYOD1 GATA3 TLX2

5.21e-0586484int:BCL9
InteractionPRR12 interactions

NFIB MYOD1 GATA3 TLX2

5.70e-0588484int:PRR12
InteractionARID1B interactions

NFIB MYOD1 GATA3 STK11IP TLX2

6.23e-05177485int:ARID1B
InteractionZNF281 interactions

NFIB MYOD1 GLI2 GATA3 TLX2

1.03e-04197485int:ZNF281
InteractionBCL7C interactions

NFIB MYOD1 GATA3 STK11IP

1.61e-04115484int:BCL7C
CytobandEnsembl 112 genes in cytogenetic band chr2q35

MARCHF4 STK11IP SLC4A3

3.63e-04129493chr2q35
GeneFamilyTALE class homeoboxes and pseudogenes

IRX3 IRX1

9.01e-0426312526
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZIC5 GLI2 SP6 GLIS3 ZNF783 ZIC2

1.21e-0371831628
CoexpressionAtlasFacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_1000_k-means-cluster#3

ZIC5 GLIS3 IRX1 ZIC2

2.11e-0572484Facebase_RNAseq_e8.5_Paraxial Mesoderm_1000_K3
CoexpressionAtlasECTO blastocyst_vs_ECTO UCB CD34+Z-Confounder_removed-fold2.0_adjp0.05

ZIC5 VASN GATA3 IRX3 IRX1 ZIC2

4.16e-05284486PCBC_ratio_ECTO blastocyst_vs_ECTO UCB CD34+Z_cfr-2X-p05
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#4_top-relative-expression-ranked_500

NHSL2 NFIB KMT2E LTBP4

5.32e-0591484gudmap_developingGonad_e16.5_epididymis_500_k4
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_100

ZIC5 IRX3 IRX1 ZIC2

7.10e-0598484Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_100
CoexpressionAtlase10.5_Emin_LateralNasal_top-relative-expression-ranked_500

NFIB VASN TMEM51 GATA3 IRX3 SLC4A3

1.00e-04333486Facebase_ST1_e10.5_Emin_LateralNasal_500
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_500

IP6K3 GATA3 SP6 GLIS3 HAPLN2 IRX3 TLX2

1.15e-04495487PCBC_ratio_ECTO_vs_SC_500
CoexpressionAtlase10.5_MaxilArch_top-relative-expression-ranked_250

NFIB IRX3 GPATCH8 SLC4A3

1.19e-04112484Facebase_ST1_e10.5_MaxilArch_250
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#3

IP6K3 HAPLN2 IRX3

1.54e-0446483ratio_ECTO_vs_SC_500_K3
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

UPK3B C10orf90 IRX3 IRX1 TERT

2.37e-0619549598dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCellSkin-Mesangial|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

IP6K3 ZIC5 UPK3B MARCHF4 TERT

2.62e-06199495bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZIC5 GLI2 C10orf90 KIF7

2.12e-05148494dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZCCHC14 GATA3 CMPK2 HRG

3.65e-0517049455fe16d98ea284d05fb899888e4569c685644c7b
ToppCell15-Trachea-Mesenchymal-Mesenchyme_RSPO2+|Trachea / Age, Tissue, Lineage and Cell class

ZIC5 VASN SP6 ZIC2

4.00e-05174494fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCellfacs-Skin-Anagen-24m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFIB FBXO41 HAPLN2 LTBP4

4.09e-051754945552ff1e13f931c8cd7780726c90b5609497a648
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

IP6K3 VASN SLC4A3 FAM149A

4.18e-05176494852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

IP6K3 VASN SLC4A3 FAM149A

4.18e-05176494d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCelldroplet-Thymus-nan-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFIB VASN TMEM51 FAM149A

4.76e-05182494f6717e97e87513384149800c9fd8dea821ab9393
ToppCelldroplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFIB VASN TMEM51 FAM149A

4.76e-05182494c33b0d532822186a1e8e645500347972468718c0
ToppCellwk_08-11-Epithelial-Distal_epithelial-epi-tip_early|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GPR50 IRX3 IRX1 TERT

5.29e-051874945f9696097741b6e2b7b410c15c6b5ed883ed5eb2
ToppCelldroplet-Thymus-nan-18m-Myeloid-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFIB VASN LTBP4 FAM149A

5.29e-05187494ed69e7cbd6fb59363b0e26f24887fc49405397ce
ToppCellwk_08-11-Epithelial-Distal_epithelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GPR50 IRX3 IRX1 TERT

5.29e-05187494eefffc2c6f7fa708a96e6bf07c6ce4e6c2e90847
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYOD1 PRRT3 GLIS3 RBM20

5.29e-0518749469b47f00598d647e2a99427ebddf42c339428e47
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

VASN IRX3 RBM20 FAM149A

5.40e-05188494116ca07ee4413dcc0e9e5ac99bfee6ed7b7847c6
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZIC5 GLI2 GLIS3 ZIC2

5.63e-0519049478cc6c28b31de041c24175a98f47da256ecc15a2
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZIC5 GLI2 GLIS3 ZIC2

5.63e-05190494e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

NHSL2 NFIB GLI2 LTBP4

5.74e-0519149478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

IP6K3 NHSL2 GLI2 LTBP4

5.98e-05193494b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

C10orf90 IRX3 IRX1 TERT

6.10e-05194494c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCellControl-Multiplet|Control / Disease state, Lineage and Cell class

TJP1 NFIB GLIS3 IRX3

6.22e-05195494618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCellControl-Multiplet-Multiplet|Control / Disease state, Lineage and Cell class

TJP1 NFIB GLIS3 IRX3

6.22e-0519549406ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HAPLN2 C10orf90 QRICH2

6.31e-05704938ee9c9c78eec9dc0cec364ee7c9bc6f34d37de76
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HAPLN2 C10orf90 QRICH2

6.31e-0570493b159435487b90331d2d276f182fc8aedf88d612c
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HAPLN2 C10orf90 QRICH2

6.31e-05704937e09547b73789d789c3c464689f7998445830238
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HAPLN2 C10orf90 QRICH2

6.31e-0570493b486f7fe68743e3385809cfd64512da2f31074df
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

NHSL2 NFIB GLI2 GLIS3

6.47e-05197494fb847f2277609c31fffcdf49517243ce0684facf
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GLI2 GLIS3 SLC4A3 KIF7

6.60e-051984945cfd1c030c0940136a397b5a4b5d6ecbaecf72eb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic-Megakaryocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GLI2 GLIS3 SLC4A3 KIF7

6.60e-0519849435edf6d5bedc2181fbdd56f43e458bc39f4eca16
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic-Megakaryocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GLI2 GLIS3 SLC4A3 KIF7

6.60e-05198494ff6d9455ebfe965cc6f48197172c0ebd3bddde81
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Hematopoietic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

GLI2 GLIS3 SLC4A3 KIF7

6.60e-051984945375a2895cf995f0db4a61861093f01794707901
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Sez6_(Sez6)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLAC1 HAPLN2 C10orf90

8.07e-05764932b1d7bafad3d9a01fc47790418160950330576c5
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Sez6_(Sez6)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLAC1 HAPLN2 C10orf90

8.07e-0576493322c3a4c3abdc419f162861ecd52c0ad6ef2381c
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PLAC1 IP6K3 IRX1

1.29e-0489493b66575739cb5b89234bbb8a3ea2f244e0bd19cff
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

PLAC1 IP6K3 IRX1

1.29e-048949326f01e8530b313dd5e95ea6c20fa362e34b9ed24
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IP6K3 GLI2 GLIS3

1.67e-0497493031bc124739541b0b2591e1b6ef41f12adfd5c18
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLAC1 HAPLN2 C10orf90

1.67e-04974934b74b3c5b9590a8215b7370b37e9723e9f040b9c
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PLAC1 HAPLN2 C10orf90

1.67e-04974937b17dc28454949a23701ab127300a29a8899d7d6
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IP6K3 GLI2 GLIS3

1.67e-04974930cd19f619f10a35d3107518aa83c0eda0572930a
ToppCellFrontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

IP6K3 GLI2 GLIS3

1.67e-049749333330ac2de9e49d78b478f175068999235c9af25
DrugLevamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A

PLAC1 NFIB RANBP3 PCSK7 SF3A2 ZNF783

3.74e-061994862257_DN
Drugglyphosate

MYOD1 GLI2 GATA3 IRX3 ZIC2 KIF7

5.83e-06215486CID000003496
DiseaseLung diseases

IRX3 IRX1 TERT LTBP4

6.78e-0678464C0024115
Diseasegallbladder carcinoma (is_implicated_in)

UBR5 TERT

2.37e-055462DOID:4948 (is_implicated_in)
DiseaseHoloprosencephaly sequence

GLI2 ZIC2

1.06e-0410462cv:C0079541
DiseaseAlobar Holoprosencephaly

GLI2 ZIC2

2.46e-0415462C0431363
DiseaseLobar Holoprosencephaly

GLI2 ZIC2

2.81e-0416462C0431362
DiseaseSemilobar Holoprosencephaly

GLI2 ZIC2

2.81e-0416462C0751617
Diseaseleptin measurement, type 2 diabetes mellitus

SP6 GLIS3

2.81e-0416462EFO_0005000, MONDO_0005148
DiseaseHodgkins lymphoma

IP6K3 MYOD1 GATA3

2.88e-0482463EFO_0000183
DiseaseHoloprosencephaly

GLI2 ZIC2

3.19e-0417462C0079541
DiseaseIniencephaly

ZIC5 ZIC2

8.76e-0428462C0152234
DiseasePigmented Basal Cell Carcinoma

GLI2 TERT

8.76e-0428462C1368275
DiseaseTethered Cord Syndrome

ZIC5 ZIC2

8.76e-0428462C0080218
DiseaseSpinal Cord Myelodysplasia

ZIC5 ZIC2

8.76e-0428462C0344479
DiseaseExencephaly

ZIC5 ZIC2

8.76e-0428462C0266453
DiseaseNeurenteric Cyst

ZIC5 ZIC2

8.76e-0428462C0027806
DiseaseAcrania

ZIC5 ZIC2

8.76e-0428462C0702169
DiseaseDiastematomyelia

ZIC5 ZIC2

8.76e-0428462C0011999
DiseaseCraniorachischisis

ZIC5 ZIC2

9.40e-0429462C0152426
DiseaseCarcinoma, Basal Cell

GLI2 TERT

9.40e-0429462C4721806
DiseaseNeural Tube Defects

ZIC5 ZIC2

1.01e-0330462C0027794
Diseasepeak expiratory flow

ZCCHC14 ZIC5 GLIS3 KMT2E LTBP4

1.04e-03498465EFO_0009718

Protein segments in the cluster

PeptideGeneStartEntry
GNHHPTPSHGPDGAV

SLC4A3

451

P48751
PRGEAEAPHHGTGHP

RANBP3

41

Q9H6Z4
PHGHAGVPQHAAAIP

RBM20

146

Q5T481
LSTFPQHHHPGIPGV

NFIB

336

O00712
HPDQQHVASPGPGEH

QRICH2

906

Q9H0J4
PAHPLLAHTGGHQSP

KRBA1

946

A5PL33
NINGVPPHLGHPFHW

HRG

251

P04196
GPPYAHKNPHTGHVN

MAGT1

241

Q9H0U3
FHKAQGDPASHPGPH

HAPLN2

21

Q9GZV7
VLVPHAHADGASGPP

FAM149A

501

A5PLN7
AGHPDRASGHPKPHS

GPR50

376

Q13585
AAAAAIGIHPHPHPQ

GPATCH8

1386

Q9UKJ3
PMPHPDVENGNHHGT

PCSK7

216

Q16549
EHSHFPAAVHPAPGA

MYOD1

61

P15172
PRPHTAPLGGAHAHV

KIF7

561

Q2M1P5
GHHVTPGHFLPSQNP

KMT2E

1601

Q8IZD2
EPHSVHGVHGPPALS

GLI2

76

P10070
GSPHPHEAPQAAHGS

IP6K3

341

Q96PC2
PAVLNGQHPDTHHPG

GATA3

16

P23771
SGGLQHLPPAHHPVY

CMPK2

346

Q5EBM0
PHPVSHPSPGHNVQG

GLIS3

576

Q8NEA6
HPSPGHNVQGSPHNP

GLIS3

581

Q8NEA6
HHAPLAHFPGDLVPA

FBXO41

111

Q8TF61
PAQAAGHPSGPLSHH

MARCHF4

361

Q9P2E8
PGFAPTHQPHHCAPA

LTBP4

1606

Q8N2S1
AVAPHPVGHPHLTFI

PRRT3

141

Q5FWE3
VQHPAAAAAFPHPHP

IRX3

101

P78415
HHDPAGLGQPLHVPS

PLEKHM2

481

Q8IWE5
HLGLGCPPNHVQPHA

PLAC1

56

Q9HBJ0
SASPVCHPPGHGDHL

STK11IP

741

Q8N1F8
HSSHPDAQGHPAIPN

NHSL2

611

Q5HYW2
PCVHHHGSPGVDLPV

NBR1

826

Q14596
FLGVGAPHAAPHGPH

IRX1

391

P78414
PHPHAHHLLPAAGGQ

SP6

166

Q3SY56
APGVHPAAPAVHPQA

SF3A2

376

Q15428
APPALANGAHPGRHQ

C10orf90

176

Q96M02
DPETSHGGHPHGNMP

SEC16A

166

O15027
PTPSILHQGPGHEQH

SEC16A

251

O15027
HQQHHGPPLCSPDGA

SYT15B

81

X6R8R1
DLAHVQHPTGAGPHA

TMEM51

96

Q9NW97
GEAHTPPAVHSNHAP

VASN

551

Q6EMK4
AGHFEPLHGAAAVPP

TJP1

1211

Q07157
QHHGQHPAGSAAPLP

ZCCHC14

246

Q8WYQ9
AAAHVLEAGEHPPGP

ZNHIT2

266

Q9UHR6
HGQALHDPPHPTQRG

UPK3B

271

Q9BT76
HPSVGRQHHAGPPST

TERT

296

O14746
SAGDPGHPNHPLHAS

UBR5

1861

O95071
HLLFPGLPEQHGPHG

ZIC2

156

O95409
LGPHNLPHHEPISFG

TLX2

6

O43763
HARGQVGPHFPAAPA

ZNF783

516

Q6ZMS7
AAAAAGPGPHLQHHA

ZIC5

341

Q96T25