Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cholecystokinin receptor activity	CCKAR CCKBR	2.49e-06	2	32	2	GO:0004951
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC13A5 SLC2A8 SLC2A6 SLC66A1 SLCO1A2 SLC22A11	6.23e-06	293	32	6	GO:0008514
GeneOntologyMolecularFunction	extracellularly glycine-gated ion channel activity	GLRA3 GLRA1	3.72e-05	6	32	2	GO:0016933
GeneOntologyMolecularFunction	extracellularly glycine-gated chloride channel activity	GLRA3 GLRA1	3.72e-05	6	32	2	GO:0016934
GeneOntologyMolecularFunction	dehydroascorbic acid transmembrane transporter activity	SLC2A8 SLC2A6	6.92e-05	8	32	2	GO:0033300
GeneOntologyMolecularFunction	inhibitory extracellular ligand-gated monoatomic ion channel activity	GLRA3 GLRA1	6.92e-05	8	32	2	GO:0005237
GeneOntologyMolecularFunction	transmembrane transporter activity	GLRA3 SLC13A5 TMC5 SLC2A8 SLC2A6 SLC66A1 SLCO1A2 GLRA1 SLC22A11	6.93e-05	1180	32	9	GO:0022857
GeneOntologyMolecularFunction	fructose transmembrane transporter activity	SLC2A8 SLC2A6	8.89e-05	9	32	2	GO:0005353
GeneOntologyMolecularFunction	transporter activity	GLRA3 SLC13A5 TMC5 SLC2A8 SLC2A6 SLC66A1 SLCO1A2 GLRA1 SLC22A11	1.37e-04	1289	32	9	GO:0005215
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GLRA3 FZD6 NMUR1 OR2T29 OR2T5 OR7A10 GLRA1 CCKAR CCKBR	1.98e-04	1353	32	9	GO:0004888
GeneOntologyMolecularFunction	glycine binding	GLRA3 GLRA1	2.24e-04	14	32	2	GO:0016594
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1A2 SLC22A11	3.75e-04	18	32	2	GO:0015347
GeneOntologyMolecularFunction	G protein-coupled receptor activity	FZD6 NMUR1 OR2T29 OR2T5 OR7A10 CCKAR CCKBR	4.15e-04	884	32	7	GO:0004930
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC2A8 SLC2A6	7.29e-04	25	32	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC2A8 SLC2A6	7.29e-04	25	32	2	GO:0015149
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC2A8 SLC2A6	8.52e-04	27	32	2	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC2A8 SLC2A6	9.83e-04	29	32	2	GO:0051119
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC13A5 SLC2A8 SLCO1A2 SLC22A11	1.23e-03	296	32	4	GO:0015291
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NMUR1 CCKAR CCKBR	1.24e-03	133	32	3	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NMUR1 CCKAR CCKBR	1.44e-03	140	32	3	GO:0001653
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	SLC2A8 SLC2A6	1.52e-03	36	32	2	GO:0090482
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC2A8 SLC2A6	2.06e-03	42	32	2	GO:0015144
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	GLRA3 GLRA1	2.16e-03	43	32	2	GO:0005231
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	GLRA3 GLRA1 SLC22A11	2.55e-03	171	32	3	GO:0015103
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	GLRA3 GLRA1	2.91e-03	50	32	2	GO:0099095
GeneOntologyMolecularFunction	peptide hormone binding	CCKAR CCKBR	3.50e-03	55	32	2	GO:0017046
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC13A5 SLC66A1 SLCO1A2	4.36e-03	207	32	3	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC13A5 SLC66A1 SLCO1A2	4.42e-03	208	32	3	GO:0005342
GeneOntologyMolecularFunction	transmitter-gated channel activity	GLRA3 GLRA1	4.86e-03	65	32	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GLRA3 GLRA1	4.86e-03	65	32	2	GO:0022824
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLCO1A2 SLC22A11	6.09e-03	73	32	2	GO:0170055
GeneOntologyMolecularFunction	amino acid binding	GLRA3 GLRA1	6.09e-03	73	32	2	GO:0016597
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	GLRA3 GLRA1	6.75e-03	77	32	2	GO:0005230
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC13A5 SLC2A8 SLCO1A2 SLC22A11	6.81e-03	477	32	4	GO:0022804
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC66A1 SLCO1A2	7.81e-03	83	32	2	GO:0015101
GeneOntologyMolecularFunction	chloride channel activity	GLRA3 GLRA1	8.36e-03	86	32	2	GO:0005254
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GLRA3 GLRA1	1.12e-02	100	32	2	GO:0030594
GeneOntologyMolecularFunction	hormone binding	CCKAR CCKBR	1.18e-02	103	32	2	GO:0042562
GeneOntologyMolecularFunction	monoatomic anion channel activity	GLRA3 GLRA1	1.18e-02	103	32	2	GO:0005253
GeneOntologyMolecularFunction	amide binding	FZD6 CCKAR CCKBR	1.20e-02	299	32	3	GO:0033218
GeneOntologyMolecularFunction	peptide binding	FZD6 NMUR1 CCKAR	1.41e-02	318	32	3	GO:0042277
GeneOntologyBiologicalProcess	organic anion transport	SLC13A5 SLC2A8 SLC2A6 SLC66A1 SLCO1A2 KMO SLC22A11	5.63e-06	515	29	7	GO:0015711
GeneOntologyBiologicalProcess	cholecystokinin signaling pathway	CCKAR CCKBR	5.72e-06	3	29	2	GO:0038188
GeneOntologyBiologicalProcess	positive regulation of somatostatin secretion	CCKAR CCKBR	1.14e-05	4	29	2	GO:0090274
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	FZD6 NMUR1 OR2T29 OR2T5 PLCB2 OR7A10 PIK3CB GLRA1 CCKAR CCKBR	1.18e-05	1395	29	10	GO:0007186
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	NMUR1 PLCB2 CCKAR CCKBR	3.46e-05	133	29	4	GO:0007200
GeneOntologyBiologicalProcess	regulation of somatostatin secretion	CCKAR CCKBR	3.99e-05	7	29	2	GO:0090273
GeneOntologyBiologicalProcess	somatostatin secretion	CCKAR CCKBR	6.83e-05	9	29	2	GO:0070253
GeneOntologyBiologicalProcess	dehydroascorbic acid transport	SLC2A8 SLC2A6	6.83e-05	9	29	2	GO:0070837
GeneOntologyBiologicalProcess	monoatomic ion transport	GLRA3 SLC13A5 NMUR1 PLCB2 TMC5 SLCO1A2 GLRA1 CCKAR SLC22A11	7.44e-05	1374	29	9	GO:0006811
GeneOntologyBiologicalProcess	fructose transmembrane transport	SLC2A8 SLC2A6	8.53e-05	10	29	2	GO:0015755
GeneOntologyBiologicalProcess	inorganic anion transport	GLRA3 NMUR1 GLRA1 SLC22A11	1.12e-04	180	29	4	GO:0015698
GeneOntologyBiologicalProcess	monoatomic anion transport	GLRA3 NMUR1 SLCO1A2 GLRA1	1.20e-04	183	29	4	GO:0006820
GeneOntologyBiologicalProcess	gastric acid secretion	CCKAR CCKBR	2.26e-04	16	29	2	GO:0001696
GeneOntologyBiologicalProcess	carboxylic acid transport	SLC13A5 SLC66A1 SLCO1A2 KMO SLC22A11	2.43e-04	410	29	5	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	SLC13A5 SLC66A1 SLCO1A2 KMO SLC22A11	2.48e-04	412	29	5	GO:0015849
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PLCB2 PIK3CB	5.17e-04	24	29	2	GO:0048015
GeneOntologyBiologicalProcess	cellular response to ethanol	GLRA3 GLRA1	5.61e-04	25	29	2	GO:0071361
GeneOntologyBiologicalProcess	cellular response to zinc ion	GLRA3 GLRA1	7.05e-04	28	29	2	GO:0071294
GeneOntologyBiologicalProcess	digestive system process	SLCO1A2 CCKAR CCKBR	7.24e-04	126	29	3	GO:0022600
GeneOntologyBiologicalProcess	chloride transport	GLRA3 NMUR1 GLRA1	7.58e-04	128	29	3	GO:0006821
GeneOntologyBiologicalProcess	organic cation transport	SLC66A1 SLCO1A2 NISCH	1.09e-03	145	29	3	GO:0015695
GeneOntologyCellularComponent	glycinergic synapse	GLRA3 GLRA1	4.24e-04	20	32	2	GO:0098690
Domain	Cholcskin_rcpt	CCKAR CCKBR	2.84e-06	2	32	2	IPR009126
Domain	Glycine_rcpt_A	GLRA3 GLRA1	1.70e-05	4	32	2	IPR008127
Domain	Sugar_tr	SLC2A8 SLC2A6 SLC22A11	3.14e-05	36	32	3	PF00083
Domain	MFS_sugar_transport-like	SLC2A8 SLC2A6 SLC22A11	3.14e-05	36	32	3	IPR005828
Domain	MFS	SLC2A8 SLC2A6 SLCO1A2 SLC22A11	3.36e-05	108	32	4	PS50850
Domain	MFS_dom	SLC2A8 SLC2A6 SLCO1A2 SLC22A11	7.79e-05	134	32	4	IPR020846
Domain	Sugar/inositol_transpt	SLC2A8 SLC2A6	2.55e-04	14	32	2	IPR003663
Domain	SUGAR_TRANSPORT_2	SLC2A8 SLC2A6	3.81e-04	17	32	2	PS00217
Domain	GABAA/Glycine_rcpt	GLRA3 GLRA1	7.04e-04	23	32	2	IPR006028
Domain	SUGAR_TRANSPORT_1	SLC2A8 SLC2A6	7.67e-04	24	32	2	PS00216
Domain	GPCR_Rhodpsn_7TM	NMUR1 OR2T29 OR2T5 OR7A10 CCKAR CCKBR	8.51e-04	670	32	6	IPR017452
Domain	7tm_1	NMUR1 OR2T29 OR2T5 OR7A10 CCKAR CCKBR	8.98e-04	677	32	6	PF00001
Domain	G_PROTEIN_RECEP_F1_1	NMUR1 OR2T29 OR2T5 OR7A10 CCKAR CCKBR	9.54e-04	685	32	6	PS00237
Domain	G_PROTEIN_RECEP_F1_2	NMUR1 OR2T29 OR2T5 OR7A10 CCKAR CCKBR	9.99e-04	691	32	6	PS50262
Domain	GPCR_Rhodpsn	NMUR1 OR2T29 OR2T5 OR7A10 CCKAR CCKBR	1.01e-03	692	32	6	IPR000276
Domain	Sugar_transporter_CS	SLC2A8 SLC2A6	1.37e-03	32	32	2	IPR005829
Domain	-	PLCB2 PIK3CB RASAL2	2.04e-03	148	32	3	2.60.40.150
Domain	Neurotransmitter_ion_chnl_CS	GLRA3 GLRA1	2.69e-03	45	32	2	IPR018000
Domain	C2_dom	PLCB2 PIK3CB RASAL2	2.73e-03	164	32	3	IPR000008
Domain	Neur_chan_memb	GLRA3 GLRA1	2.81e-03	46	32	2	PF02932
Domain	Neur_chan_LBD	GLRA3 GLRA1	2.93e-03	47	32	2	PF02931
Domain	Neur_channel	GLRA3 GLRA1	2.93e-03	47	32	2	IPR006201
Domain	Neur_chan_lig-bd	GLRA3 GLRA1	2.93e-03	47	32	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	GLRA3 GLRA1	2.93e-03	47	32	2	PS00236
Domain	Neurotrans-gated_channel_TM	GLRA3 GLRA1	2.93e-03	47	32	2	IPR006029
Domain	-	GLRA3 GLRA1	2.93e-03	47	32	2	2.70.170.10
Domain	PH_dom-like	NBEA PLCB2 SNTB2 RASAL2	5.79e-03	426	32	4	IPR011993
Domain	-	INTS14 CFB	7.11e-03	74	32	2	3.40.50.410
Domain	VWFA	INTS14 CFB	8.67e-03	82	32	2	PS50234
Domain	VWA	INTS14 CFB	9.08e-03	84	32	2	SM00327
Domain	VWF_A	INTS14 CFB	1.24e-02	99	32	2	IPR002035
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC13A5 SLC2A8 SLC2A6 SLCO1A2 SLC22A11	1.16e-04	249	28	5	M5988
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	PLCB2 CCKAR CCKBR	1.29e-04	50	28	3	M47951
Pathway	WP_ACQUIRED_PARTIAL_LIPODYSTROPHY_BARRAQUERSIMONS_SYNDROME	RCE1 CFB	1.70e-04	10	28	2	M42576
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GLRA3 NMUR1 GLRA1 CCKAR CCKBR	1.76e-04	272	28	5	M13380
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NMUR1 OR7A10 CCKAR CCKBR	4.69e-04	186	28	4	MM15994
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A8 SLC2A6	6.37e-04	19	28	2	MM14718
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GLRA3 NBEA PLCB2 GLRA1	6.76e-04	205	28	4	M752
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	NMUR1 PLCB2 CCKAR CCKBR	7.40e-04	210	28	4	MM15043
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A8 SLC2A6	7.81e-04	21	28	2	M27058
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	NMUR1 PLCB2 CCKAR CCKBR	8.37e-04	217	28	4	M18437
Pubmed	Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze.	CCKAR CCKBR	8.20e-07	2	32	2	12459512
Pubmed	Characterization of the glycinergic input to bipolar cells of the mouse retina.	GLRA3 GLRA1	8.20e-07	2	32	2	16420443
Pubmed	Expression of cholecystokinin receptors in colon cancer and the clinical correlation in Taiwan.	CCKAR CCKBR	8.20e-07	2	32	2	26508021
Pubmed	Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature.	CCKAR CCKBR	8.20e-07	2	32	2	15178543
Pubmed	Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor.	CCKAR CCKBR	8.20e-07	2	32	2	8343165
Pubmed	Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons.	CCKAR CCKBR	8.20e-07	2	32	2	23038256
Pubmed	Structure and developmental expression of the mouse CCK-B receptor gene.	CCKAR CCKBR	8.20e-07	2	32	2	10860839
Pubmed	Heterogeneous expression of cholecystokinin and gastrin receptor in stomach and pancreatic cancer: An immunohistochemical study.	CCKAR CCKBR	8.20e-07	2	32	2	27072272
Pubmed	Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors.	CCKAR CCKBR	8.20e-07	2	32	2	25160855
Pubmed	Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.	GLRA3 GLRA1	8.20e-07	2	32	2	19959465
Pubmed	Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety.	CCKAR CCKBR	8.20e-07	2	32	2	23043971
Pubmed	[The expression of cholecystokinin-octapeptide receptor in vascular endothelial cells induced by lipopolysaccharide].	CCKAR CCKBR	8.20e-07	2	32	2	19751565
Pubmed	Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.	CCKAR CCKBR	8.20e-07	2	32	2	39083706
Pubmed	The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.	CCKAR CCKBR	8.20e-07	2	32	2	29163209
Pubmed	Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice.	CCKAR CCKBR	8.20e-07	2	32	2	19340558
Pubmed	Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort.	CCKAR CCKBR	8.20e-07	2	32	2	26608796
Pubmed	Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse.	GLRA3 GLRA1	8.20e-07	2	32	2	21486794
Pubmed	Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor.	CCKAR CCKBR	8.20e-07	2	32	2	11925470
Pubmed	Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.	GLRA3 GLRA1	8.20e-07	2	32	2	23834509
Pubmed	Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors.	CCKAR CCKBR	8.20e-07	2	32	2	18444993
Pubmed	Heterodimerization of type A and B cholecystokinin receptors enhance signaling and promote cell growth.	CCKAR CCKBR	8.20e-07	2	32	2	14534299
Pubmed	Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue.	CCKAR CCKBR	8.20e-07	2	32	2	12851875
Pubmed	Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: a study of CCK-A,B, and AB receptor gene knockout mice.	CCKAR CCKBR	8.20e-07	2	32	2	15168241
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GLRA3 GLRA1 CCKAR CCKBR	9.34e-07	81	32	4	22723691
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	GLRA3 NBEA GLRA1	2.04e-06	27	32	3	19723784
Pubmed	Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.	CCKAR CCKBR	2.46e-06	3	32	2	20732371
Pubmed	Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection.	CCKAR CCKBR	2.46e-06	3	32	2	37123227
Pubmed	Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit.	GLRA3 GLRA1	2.46e-06	3	32	2	17154252
Pubmed	Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism.	CCKAR CCKBR	2.46e-06	3	32	2	12198366
Pubmed	Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.	GLRA3 GLRA1	2.46e-06	3	32	2	17920294
Pubmed	Gene variations in the cholecystokinin system in patients with panic disorder.	CCKAR CCKBR	2.46e-06	3	32	2	20023595
Pubmed	Placental growth factor enhances angiogenesis in human intestinal microvascular endothelial cells via PI3K/Akt pathway: Potential implications of inflammation bowel disease.	PIK3CB PGF	2.46e-06	3	32	2	26775845
Pubmed	No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence.	CCKAR CCKBR	2.46e-06	3	32	2	11368834
Pubmed	Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system.	CCKAR CCKBR	2.46e-06	3	32	2	15313848
Pubmed	Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease.	CCKAR CCKBR	2.46e-06	3	32	2	12777967
Pubmed	Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin.	CCKAR CCKBR	2.46e-06	3	32	2	22357963
Pubmed	Lack of ghrelin secretion in response to fasting in cholecystokinin-A (-1), -B (-2) receptor-deficient mice.	CCKAR CCKBR	2.46e-06	3	32	2	17134539
Pubmed	Glycinergic input of widefield, displaced amacrine cells of the mouse retina.	GLRA3 GLRA1	4.92e-06	4	32	2	19528249
Pubmed	Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.	GLRA3 GLRA1	4.92e-06	4	32	2	9051263
Pubmed	Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.	GLRA3 GLRA1	4.92e-06	4	32	2	28883437
Pubmed	Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.	GLRA3 GLRA1	4.92e-06	4	32	2	21486797
Pubmed	Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse.	CCKAR CCKBR	4.92e-06	4	32	2	7759110
Pubmed	Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.	CCKAR CCKBR	4.92e-06	4	32	2	26948890
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	GLRA3 NBEA GLRA1 CCKAR CCKBR	7.68e-06	300	32	5	19086053
Pubmed	Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.	GLRA3 GLRA1	8.19e-06	5	32	2	21850450
Pubmed	Native glycine receptor subtypes and their physiological roles.	GLRA3 GLRA1	8.19e-06	5	32	2	18721822
Pubmed	Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells.	CCKAR CCKBR	1.23e-05	6	32	2	10536058
Pubmed	Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex.	GLRA3 GLRA1	1.72e-05	7	32	2	22988142
Pubmed	Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.	SLC2A8 SLC2A6	1.72e-05	7	32	2	12554125
Pubmed	Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.	PLCB2 SNTB2	1.72e-05	7	32	2	21115837
Pubmed	Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons.	CCKAR CCKBR	2.29e-05	8	32	2	15152034
Pubmed	New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice.	SLCO1A2 CCKAR	2.94e-05	9	32	2	12837957
Pubmed	Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.	SLC2A8 SLC2A6	2.94e-05	9	32	2	19554504
Pubmed	Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.	CCKAR CCKBR	2.94e-05	9	32	2	18832011
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2T29 OR2T5 OR7A10	4.39e-05	74	32	3	15081110
Pubmed	Localization of the murine cholecystokinin A and B receptor genes.	CCKAR CCKBR	4.49e-05	11	32	2	7613026
Pubmed	Screening of the interaction between xenobiotic transporters and PDZ proteins.	SLCO1A2 SLC22A11	8.55e-05	15	32	2	15553237
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	PIK3CB CCKAR CCKBR	1.71e-04	117	32	3	18996102
Pubmed	Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.	CCKAR CCKBR	2.05e-04	23	32	2	25875176
Pubmed	Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes.	GLRA1 CCKAR	2.24e-04	24	32	2	9606417
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	GLRA1 CCKAR CCKBR	2.34e-04	130	32	3	19874574
Pubmed	Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy.	SLC2A8 SLC2A6	2.43e-04	25	32	2	35478964
Pubmed	Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.	GLRA3 CCKBR	3.51e-04	30	32	2	27568567
Pubmed	Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?	PIK3CB CCKAR CCKBR	7.30e-04	192	32	3	20602615
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	PLCB2 PIK3CB	8.64e-04	47	32	2	14968112
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	SLCO1A2 CCKAR	8.64e-04	47	32	2	11208732
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	OR2T29 OR2T5 NBEA	8.82e-04	205	32	3	12040188
Interaction	CCKAR interactions	CCKAR CCKBR	6.86e-06	3	31	2	int:CCKAR
Cytoband	1q44	OR2T29 OR2T5	2.69e-03	110	32	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T29 OR2T5	3.62e-03	128	32	2	chr1q44
GeneFamily	Cholecystokinin receptors	CCKAR CCKBR	2.15e-06	2	27	2	224
GeneFamily	Glycine receptors	GLRA3 GLRA1	2.14e-05	5	27	2	868
GeneFamily	Solute carriers	SLC13A5 SLC2A8 SLC2A6 SLCO1A2 SLC22A11	2.63e-04	395	27	5	752
GeneFamily	Olfactory receptors, family 2	OR2T29 OR2T5	1.23e-02	113	27	2	149
Coexpression	DESCARTES_FETAL_ADRENAL_CSH1_CSH2_POSITIVE_CELLS	TMC5 SCIN PGF KMO SLC22A11	5.22e-06	224	30	5	M40145
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b-.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-2	SCIN PIK3CB SLC2A6 KMO CFB RASAL2	1.19e-05	403	28	6	GSM605834_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b-.MLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-3	SCIN PIK3CB SLC2A6 KMO CFB RASAL2	1.46e-05	418	28	6	GSM605836_500
CoexpressionAtlas	kidney_adult_RenMedVasc_Tie2_k-means-cluster#1_top-relative-expression-ranked_200	SCIN CFB	9.15e-05	11	28	2	gudmap_kidney_adult_RenMedVasc_Tie2_k1_200
CoexpressionAtlas	Stromal Cells, Ep.MEChi.Th, CD45- EpCAm+ Ly51- MHCIIhi, Thymus, avg-2	FZD6 NBEA SCIN CFB RASAL2	1.31e-04	384	28	5	GSM777041_500
CoexpressionAtlas	Myeloid Cells, DC.4+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3	PIK3CB SLC2A6 KMO CFB RASAL2	1.59e-04	400	28	5	GSM538242_500
CoexpressionAtlas	Stromal Cells, Ep.MEChi.Th, CD45-EpCAm+Ly51-MHCIIhi, Thymus, avg-1	FZD6 NBEA SCIN CFB RASAL2	1.80e-04	411	28	5	GSM854302_500
CoexpressionAtlas	Myeloid Cells, DC.IIhilang+103-11b+.SLN, MHCIIhi CD11c+ Langerin+ CD103- CD11b+, Lymph Node, avg-3	NBEA SCIN SLC2A6 CFB RASAL2	1.80e-04	411	28	5	GSM538271_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b+.MLN, CD45-APC CD11b-FITC CD11c-eFluor780 CD4-PE CD8a-eF, Lymph Node, avg-2	PIK3CB SLC2A6 KMO CFB RASAL2	1.85e-04	413	28	5	GSM538263_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-1	PIK3CB SLC2A6 KMO CFB RASAL2	1.87e-04	414	28	5	GSM538262_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b-.SLN, CD11b-FITC CD4-PE CD11c-eFluor780 CD8a-eFluor450 C, Lymph Node, avg-3	SCIN PIK3CB SLC2A6 KMO RASAL2	1.95e-04	418	28	5	GSM854291_500
Computational	AcetylCholine receptors.	GLRA3 GLRA1	2.12e-04	14	17	2	MODULE_328
Computational	Genes in the cancer module 267.	GLRA3 GLRA1	2.44e-04	15	17	2	MODULE_267
Computational	Neurotransmitter (GABA) receptor.	GLRA3 GLRA1	2.44e-04	15	17	2	MODULE_215
Computational	Ion channels.	GLRA3 GLRA1	8.07e-04	27	17	2	MODULE_214
Computational	Neighborhood of FLT1	GPATCH8 PIK3CB CCKAR	9.48e-04	126	17	3	MORF_FLT1
Drug	Cholecystokinin	CCKAR CCKBR	1.91e-06	2	32	2	ctd:D002766
Drug	cholecystokinin pentapeptide	CCKAR CCKBR	1.91e-06	2	32	2	ctd:C049128
Drug	FC28	CCKAR CCKBR	1.91e-06	2	32	2	CID000203398
Drug	Cycam	NMUR1 CCKAR CCKBR	2.03e-06	18	32	3	CID000122080
Drug	Jmv 332	CCKAR CCKBR	5.74e-06	3	32	2	CID006444167
Drug	U-67827e	CCKAR CCKBR	5.74e-06	3	32	2	CID000128399
Drug	CBZ-cysteine	CCKAR CCKBR	5.74e-06	3	32	2	CID000097524
Drug	Wy-27587	CCKAR CCKBR	5.74e-06	3	32	2	CID000182584
Drug	Pd 140376	CCKAR CCKBR	5.74e-06	3	32	2	CID000196935
Drug	Ksg 504	CCKAR CCKBR	5.74e-06	3	32	2	CID000132011
Drug	AC1Q6XIX	CCKAR CCKBR	5.74e-06	3	32	2	CID000128819
Drug	phenoxyacetylproglumide	CCKAR CCKBR	5.74e-06	3	32	2	CID000126961
Drug	indole-2-carboxamide	CCKAR CCKBR	5.74e-06	3	32	2	CID000594832
Drug	tebufenpyrad	CCKAR CCKBR	5.74e-06	3	32	2	CID000086354
Drug	iso-THAZ	GLRA3 GLRA1	1.15e-05	4	32	2	CID003047783
Drug	Snf 8702	CCKAR CCKBR	1.15e-05	4	32	2	CID000131086
Drug	SC-48981	GLRA3 GLRA1	1.15e-05	4	32	2	CID000126573
Drug	protostrychnine	GLRA3 GLRA1	1.15e-05	4	32	2	CID005320746
Drug	7-nitroindoline	GLRA3 GLRA1	1.15e-05	4	32	2	CID013566747
Drug	SC-50132	GLRA3 GLRA1	1.15e-05	4	32	2	CID000195719
Drug	MAPN	CCKAR CCKBR	1.15e-05	4	32	2	CID000151286
Drug	GB-115	CCKAR CCKBR	1.15e-05	4	32	2	CID000060130
Drug	L-368,935	CCKAR CCKBR	1.15e-05	4	32	2	CID000197533
Drug	2-(phosphonomethyl)phenylalanine	GLRA3 GLRA1	1.15e-05	4	32	2	CID000383689
Drug	SC-49648	GLRA3 GLRA1	1.15e-05	4	32	2	CID000195696
Drug	pBC 264	CCKAR CCKBR	1.15e-05	4	32	2	CID005491702
Drug	SR 42641	GLRA3 GLRA1	1.15e-05	4	32	2	CID000129049
Drug	akuammiline	GLRA3 GLRA1	1.15e-05	4	32	2	CID005367018
Drug	gallogen	CCKAR CCKBR	1.15e-05	4	32	2	CID000021853
Drug	NSC381080	GLRA3 GLRA1	1.15e-05	4	32	2	CID000165497
Drug	N-methyl-THIP	GLRA3 GLRA1	1.15e-05	4	32	2	CID000134373
Drug	C6H12NO5P	GLRA3 KMO GLRA1	1.74e-05	36	32	3	CID000104962
Drug	azetidine-3-carboxylic acid	GLRA3 GLRA1	1.91e-05	5	32	2	CID000093192
Drug	T-0632	CCKAR CCKBR	1.91e-05	5	32	2	CID000127948
Drug	Lindane	GLRA3 GLRA1	1.91e-05	5	32	2	DB00431
Drug	Cao C	GLRA3 GLRA1	1.91e-05	5	32	2	CID000166617
Drug	MCI-727	CCKAR CCKBR	1.91e-05	5	32	2	CID006336097
Drug	oxanilide	GLRA3 GLRA1	1.91e-05	5	32	2	CID000069288
Drug	A 70874	CCKAR CCKBR	1.91e-05	5	32	2	CID006439313
Drug	CR 1392	CCKAR CCKBR	1.91e-05	5	32	2	CID000065852
Drug	Des(SO3)cck-8	CCKAR CCKBR	1.91e-05	5	32	2	CID003084441
Drug	ALX1393	GLRA3 GLRA1	1.91e-05	5	32	2	CID016078939
Drug	8-sulfocholecystokinin octapeptide	CCKAR CCKBR	1.91e-05	5	32	2	ctd:C090019
Drug	A-65186	CCKAR CCKBR	1.91e-05	5	32	2	CID003081191
Drug	AC1Q5XGY	CCKAR CCKBR	1.91e-05	5	32	2	CID000041315
Drug	AC1Q6XJ0	CCKAR CCKBR	1.91e-05	5	32	2	CID000124911
Drug	iso-THAO	GLRA3 GLRA1	1.91e-05	5	32	2	CID000127199
Drug	pleiocarpamine	GLRA3 GLRA1	1.91e-05	5	32	2	CID000558637
Drug	mafoprazine	GLRA3 GLRA1	1.91e-05	5	32	2	CID000071241
Drug	gevotroline	GLRA3 GLRA1	1.91e-05	5	32	2	CID000060546
Drug	thiomuscimol	GLRA3 GLRA1	2.86e-05	6	32	2	CID000005448
Drug	THAZ	GLRA3 GLRA1	2.86e-05	6	32	2	CID000171289
Drug	mV GABA	GLRA3 GLRA1	2.86e-05	6	32	2	CID000128435
Drug	caged glycine	GLRA3 GLRA1	2.86e-05	6	32	2	CID000192642
Drug	LY288513	CCKAR CCKBR	2.86e-05	6	32	2	CID000132190
Drug	lauryl methacrylate	CCKAR CCKBR	2.86e-05	6	32	2	CID000008906
Drug	A-71378	CCKAR CCKBR	2.86e-05	6	32	2	CID006918156
Drug	brometone	GLRA3 GLRA1	2.86e-05	6	32	2	CID000006424
Drug	thio-THIP	GLRA3 GLRA1	2.86e-05	6	32	2	CID000656720
Drug	AC1L90PQ	GLRA3 GLRA1	2.86e-05	6	32	2	CID000436036
Drug	CCK-6	CCKAR CCKBR	2.86e-05	6	32	2	CID003082185
Drug	Boc-cck7	CCKAR CCKBR	2.86e-05	6	32	2	CID003082175
Drug	minaxolone	GLRA3 GLRA1	2.86e-05	6	32	2	CID000071960
Drug	Btlasp-NH2	CCKAR CCKBR	2.86e-05	6	32	2	CID000152221
Drug	L-365,031	CCKAR CCKBR	2.86e-05	6	32	2	CID000196641
Drug	Cu-cyclam	KNTC1 NMUR1 CCKBR	3.00e-05	43	32	3	CID000467374
Drug	7-chlorokynurenic acid	GLRA3 KMO GLRA1	3.44e-05	45	32	3	CID000001884
Drug	propyl methanethiosulfonate	GLRA3 GLRA1	4.00e-05	7	32	2	CID000529387
Drug	alpha-EMTBL	GLRA3 GLRA1	4.00e-05	7	32	2	CID000128423
Drug	thiocolchicoside	GLRA3 GLRA1	4.00e-05	7	32	2	CID000072067
Drug	L-serinamide	GLRA3 GLRA1	4.00e-05	7	32	2	CID000101138
Drug	Boc-glycine	GLRA3 GLRA1	4.00e-05	7	32	2	CID000078288
Drug	CID189778	GLRA3 GLRA1	4.00e-05	7	32	2	CID000189778
Drug	Jmv 320	CCKAR CCKBR	4.00e-05	7	32	2	CID003081775
Drug	PK 8165	GLRA3 GLRA1	4.00e-05	7	32	2	CID000071219
Drug	benzodiazepine	GLRA3 GLRA1 CCKAR CCKBR	4.55e-05	142	32	4	CID000134664
Drug	AC1L6VJ8	CCKAR CCKBR	5.33e-05	8	32	2	CID000300088
Drug	spiroglumide	CCKAR CCKBR	5.33e-05	8	32	2	CID000065987
Drug	Rc 3100	CCKAR CCKBR	5.33e-05	8	32	2	CID005487260
Drug	WT702	GLRA3 GLRA1	5.33e-05	8	32	2	CID000089643
Drug	isostrychnine	GLRA3 GLRA1	5.33e-05	8	32	2	CID000264626
Drug	Jmv 170	CCKAR CCKBR	5.33e-05	8	32	2	CID000196737
Drug	Jmv 179	CCKAR CCKBR	5.33e-05	8	32	2	CID000164107
Drug	AC1Q5GFY	CCKAR CCKBR	6.85e-05	9	32	2	CID000065993
Drug	Atonik	GLRA3 GLRA1	6.85e-05	9	32	2	CID000069471
Drug	nortropanol	GLRA3 GLRA1	6.85e-05	9	32	2	CID000068147
Drug	DCQX	GLRA3 GLRA1	6.85e-05	9	32	2	CID000001845
Drug	AC1NSJX8	GLRA3 GLRA1	6.85e-05	9	32	2	CID005311059
Drug	NSC129536	GLRA3 GLRA1	6.85e-05	9	32	2	CID000004815
Drug	SR 57227A	GLRA3 GLRA1	6.85e-05	9	32	2	CID000131746
Drug	nipecotic acid	GLRA3 SLCO1A2 GLRA1	7.01e-05	57	32	3	CID000004498
Drug	SR 95531	GLRA3 NISCH GLRA1	7.77e-05	59	32	3	CID000005275
Drug	glutaramic acid	CCKAR CCKBR	8.55e-05	10	32	2	CID000168356
Drug	PD135158	CCKAR CCKBR	8.55e-05	10	32	2	CID000122118
Drug	AC1MI4X0	CCKAR CCKBR	8.55e-05	10	32	2	CID003038479
Drug	Cionin	CCKAR CCKBR	8.55e-05	10	32	2	CID003083069
Drug	Gastrin hexapeptide	CCKAR CCKBR	8.55e-05	10	32	2	CID000189058
Drug	Brn 6282991	CCKAR CCKBR	8.55e-05	10	32	2	CID000023155
Drug	THBA	GLRA3 GLRA1	8.55e-05	10	32	2	CID000130993
Drug	C11688	CCKAR CCKBR	8.55e-05	10	32	2	CID000443364
Disease	pancreatic cancer (biomarker_via_orthology)	CCKAR CCKBR	1.95e-05	7	29	2	DOID:1793 (biomarker_via_orthology)
Disease	pyelonephritis (is_marker_for)	PGF CFB	1.95e-05	7	29	2	DOID:11400 (is_marker_for)
Disease	sickle cell anemia (is_marker_for)	PGF CFB	8.43e-05	14	29	2	DOID:10923 (is_marker_for)
Disease	glioblastoma (is_implicated_in)	PIK3CB PGF	2.54e-04	24	29	2	DOID:3068 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	NMUR1 PLCB2 CCKAR	1.21e-03	215	29	3	DOID:9970 (implicated_via_orthology)
Disease	glucose-dependent insulinotropic peptide measurement	NBEA SLCO1A2	1.25e-03	53	29	2	EFO_0008464
Disease	pancreatic ductal carcinoma (is_marker_for)	CCKAR CCKBR	1.65e-03	61	29	2	DOID:3587 (is_marker_for)
Disease	urinary metabolite measurement	SLCO1A2 KMO SLC22A11	1.76e-03	245	29	3	EFO_0005116
Disease	type 2 diabetes mellitus (implicated_via_orthology)	PIK3CB CCKAR	4.78e-03	105	29	2	DOID:9352 (implicated_via_orthology)
Disease	peptide measurement	GLRA3 SLCO1A2	5.14e-03	109	29	2	EFO_0010520

Protein segments in the cluster

Peptide	Gene	Start	Entry
SDLMLCLFCMPFNLI	CCKAR	86	P32238
CSMPQFFCFMQDLPP	AADACL3	66	Q5VUY0
ACMPFTLLPNLMGTF	CCKBR	106	P32239
TLTLSCPMDLKNFPM	GLRA3	166	O75311
MGSNLSPQLCLMPFI	CFB	1	P00751
ALLFFCLPMAIMSVL	NMUR1	236	Q9HB89
LLFLMGMACATPLLS	SLC66A1	136	Q6ZP29
PNFPFLLFMRASEQM	GPATCH8	406	Q9UKJ3
LFLGPLMQLSMDCPC	RCE1	126	Q9Y256
FMLTPITMSFPFCRS	OR2T5	161	Q6IEZ7
FLCPAIMSPSLFNLM	RASAL2	481	Q9UJF2
LPAFALACLMLMPHS	KNTC1	2071	P50748
IMILLLSFMPNSPRF	SLC2A6	206	Q9UGQ3
FMLTPITMSFPFCRS	OR2T29	161	Q8NH02
MEMFTFLLTCIFLPL	FZD6	1	O60353
LPNMNKSFTCTLFMP	KMO	226	O15229
FPFPSKLYIMCMANL	INTS14	146	Q96SY0
LPCLMIPSQMLLENF	SLC22A11	26	Q9NSA0
MLPCTLSASFAFMLP	SLC13A5	491	Q86YT5
PFSMAMLLSEECFIL	SCIN	271	Q9Y6U3
SMLQSLMVLPLPFCT	OR7A10	156	O76100
TLTLACPMDLKNFPM	GLRA1	161	P23415
LLLMCFMPETPRFLL	SLC2A8	196	Q9NY64
AMHLCFLPQSPLMFK	NBEA	2566	Q8NFP9
LPFMKSLSCNPIYML	SLCO1A2	306	P46721
MCFSFIMPPAMADIL	PIK3CB	1	P42338
MPVMRLFPCFLQLLA	PGF	1	P49763
FAPQHMAMLCSPILY	NISCH	811	Q9Y2I1
SNMPLTMPALFIFLE	PLCB2	786	Q00722
IFFCPLLPFIQMIML	TMC5	791	Q6UXY8
IPLKMCFAARNLSMP	SNTB2	246	Q13425
CMFFPHNTSTLIQPM	TIGD7	316	Q6NT04