Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription corepressor activity

SSX3 SSX9P PRDM8 SSX6P

5.70e-05229194GO:0003714
GeneOntologyMolecularFunctionintegrin binding

ITGB1 PRKCA ADAM22

5.78e-04175193GO:0005178
GeneOntologyMolecularFunctiontranscription coregulator activity

SSX3 SSX9P PRDM8 SSX6P

1.72e-03562194GO:0003712
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NOLC1 SSX3 SSX9P PRDM8 SSX6P

3.85e-031160195GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

NOLC1 SSX3 SSX9P PRDM8 SSX6P

7.47e-031356195GO:0060090
GeneOntologyBiologicalProcesscentral nervous system neuron axonogenesis

ATG7 PRKCA PRDM8

7.99e-0643193GO:0021955
GeneOntologyBiologicalProcesscentral nervous system development

ATG7 ITGB1 PRKCA ADAM22 PLXNA2 PRDM8 XRN2

5.92e-051197197GO:0007417
GeneOntologyBiologicalProcesscentral nervous system neuron development

ATG7 PRKCA PRDM8

9.83e-0599193GO:0021954
GeneOntologyBiologicalProcessaxonogenesis

ATG7 ITGB1 PRKCA PLXNA2 PRDM8

1.29e-04566195GO:0007409
GeneOntologyBiologicalProcesscell migration in hindbrain

ITGB1 PLXNA2

2.01e-0423192GO:0021535
GeneOntologyBiologicalProcessaxon development

ATG7 ITGB1 PRKCA PLXNA2 PRDM8

2.33e-04642195GO:0061564
GeneOntologyCellularComponentsperm flagellum

SSX3 SSX9P SSX6P

1.23e-03214213GO:0036126
GeneOntologyCellularComponentcilium

ATG7 SSX3 PRKCA SSX9P SSX6P

1.66e-03898215GO:0005929
GeneOntologyCellularComponent9+2 motile cilium

SSX3 SSX9P SSX6P

1.67e-03238213GO:0097729
GeneOntologyCellularComponentintercalated disc

ITGB1 PRKCA

2.10e-0368212GO:0014704
GeneOntologyCellularComponentcell-cell contact zone

ITGB1 PRKCA

3.97e-0394212GO:0044291
GeneOntologyCellularComponentmotile cilium

SSX3 SSX9P SSX6P

5.15e-03355213GO:0031514
DomainKRAB_RELATED

SSX2 SSX3 SSX9P SSX6P

3.88e-1011214PS50806
DomainKrueppel-associated_box-rel

SSX2 SSX3 SSX9P SSX6P

8.39e-1013214IPR003655
DomainSSX

SSX2 SSX3

1.80e-056212IPR028804
DomainSSXRD

SSX2 SSX3

3.36e-058212PF09514
DomainSSXRD_motif

SSX2 SSX3

3.36e-058212IPR019041
DomainTCEAL1

TCEAL6 TCEAL3

4.31e-059212IPR010370
DomainBEX

TCEAL6 TCEAL3

1.09e-0414212PF04538
DomainTF_A-like/BEX

TCEAL6 TCEAL3

1.09e-0414212IPR021156
DomainKRAB

SSX2 SSX3 SSX9P SSX6P

6.87e-04369214SM00349
DomainKRAB

SSX2 SSX3 SSX9P SSX6P

6.94e-04370214IPR001909
DomainPSI

ITGB1 PLXNA2

1.11e-0344212IPR016201
DomainPSI

ITGB1 PLXNA2

1.21e-0346212SM00423
DomainEGF_extracell

ITGB1 ADAM22

2.05e-0360212IPR013111
DomainEGF_2

ITGB1 ADAM22

2.05e-0360212PF07974
PathwayBIOCARTA_SPPA_PATHWAY

ITGB1 PRKCA

7.92e-0516122M8731
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

ITGB1 PLXNA2

1.13e-0419122M10959
PathwayREACTOME_SYNDECAN_INTERACTIONS

ITGB1 PRKCA

2.30e-0427122M27217
PathwayPID_SYNDECAN_4_PATHWAY

ITGB1 PRKCA

3.25e-0432122M165
Pubmed

The SSX gene family: characterization of 9 complete genes.

SSX2 SSX3 SSX9P SSX6P

5.84e-102121412216073
Pubmed

Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.

SSX3 SSX9P SSX6P

1.59e-08921314611804
Pubmed

The DNA sequence of the human X chromosome.

SSX2 SSX3 SSX9P TCEAL6 SSX6P TCEAL3

1.16e-0740721615772651
Pubmed

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

ITGB1 PRKCA

3.47e-07221212138200
Pubmed

Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction.

ITGB1 PRKCA

1.04e-06321212435334
Pubmed

Tetraspanin CD82 drives acute myeloid leukemia chemoresistance by modulating protein kinase C alpha and β1 integrin activation.

ITGB1 PRKCA

1.04e-06321232203165
Pubmed

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.

ITGB1 PRKCA

1.04e-06321226256210
Pubmed

SSX2-4 expression in early-stage non-small cell lung cancer.

SSX2 SSX3

1.04e-06321224645645
Pubmed

ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA.

ITGB1 PRKCA

2.08e-06421212509413
Pubmed

Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.

SSX2 SSX3

2.08e-06421210749136
Pubmed

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.

MLH1 NOLC1 PRKCA XRN2

2.37e-0615921431332168
Pubmed

The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.

SSX2 SSX3

9.70e-06821212007189
Pubmed

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.

ITGB1 PRKCA

3.15e-051421212919677
Pubmed

Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling.

ITGB1 PRKCA

3.63e-051521224559672
Pubmed

Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.

PRKCA TCEAL3

6.55e-052021233100228
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

MLH1 DIDO1 XRN2

7.07e-0513421325452129
Pubmed

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

PRKCA PLXNA2

7.24e-052121221835343
Pubmed

Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.

TCEAL6 TCEAL3

9.51e-052421216221301
Pubmed

Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.

ITGB1 PRKCA

9.51e-052421219300477
Pubmed

Neural tube defects by NUAK1 and NUAK2 double mutation.

ITGB1 PRKCA

1.03e-042521222689267
Pubmed

Gse1, a component of the CoREST complex, is required for placenta development in the mouse.

ITGB1 PRKCA

1.03e-042521237019373
Pubmed

Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring.

ITGB1 PLXNA2

1.12e-042621239152101
Pubmed

Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8.

ITGB1 PRKCA

1.12e-042621237060937
Pubmed

A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.

TCEAL6 TCEAL3

1.30e-042821223677977
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

NOLC1 PRKCA DIDO1 XRN2

2.13e-0450321416964243
Pubmed

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.

ITGB1 PRKCA

2.16e-043621223236519
Pubmed

F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.

MLH1 ADAM22

2.67e-044021227197753
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

NOLC1 DIDO1 XRN2

3.05e-0422021324550385
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

NOLC1 XRN2

4.52e-045221224591637
InteractionSSX2 interactions

SSX2 SSX3 SSX6P

1.15e-0545203int:SSX2
InteractionSSX6P interactions

SSX2 SSX6P

2.61e-058202int:SSX6P
InteractionSSX2B interactions

SSX2 SSX3

4.19e-0510202int:SSX2B
InteractionSSX7 interactions

SSX2 SSX3

5.12e-0511202int:SSX7
InteractionAKAP9 interactions

NOLC1 SSX2 SSX3 PRKCA

5.94e-05221204int:AKAP9
InteractionCD9 interactions

NOLC1 ITGB1 PRKCA

6.79e-0581203int:CD9
InteractionCCDC93 interactions

NCKAP5L ATG7 CNKSR3

1.31e-04101203int:CCDC93
CytobandEnsembl 112 genes in cytogenetic band chrXp11

SSX2 SSX3 SSX9P SSX6P

2.40e-05377214chrXp11
CytobandXp11.23

SSX3 SSX9P

8.67e-0495212Xp11.23
CytobandEnsembl 112 genes in cytogenetic band chrXq22

TCEAL6 TCEAL3

2.80e-03172212chrXq22
CytobandEnsembl 112 genes in cytogenetic band chr1q32

PLXNA2 ELK4

7.71e-03290212chr1q32
GeneFamilyTranscription elongation factor A like family

TCEAL6 TCEAL3

1.71e-0591321216
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

MLH1 NOLC1 ZNF341 PRKCA ADAM22

1.91e-07239175EFO_0010934
Diseasehippocampal volume

PRKCA DIDO1 PLXNA2

6.18e-04297173EFO_0005035
Diseaselung cancer (is_implicated_in)

MLH1 XRN2

8.24e-0474172DOID:1324 (is_implicated_in)
DiseaseAdenocarcinoma of large intestine

MLH1 PRKCA

1.38e-0396172C1319315
Diseaseurinary bladder cancer (is_marker_for)

MLH1 PRKCA

1.71e-03107172DOID:11054 (is_marker_for)
Diseaseovarian neoplasm

MLH1 ATG7

2.66e-03134172C0919267
DiseasePR interval

PRKCA ADAM22 CNKSR3

2.68e-03495173EFO_0004462
Diseasemean arterial pressure

ATG7 PRKCA PRDM8

2.74e-03499173EFO_0006340
DiseaseMalignant neoplasm of ovary

MLH1 ATG7

2.78e-03137172C1140680
Diseaseosteoarthritis, knee

ATG7 CNKSR3

3.68e-03158172EFO_0004616
Diseaselung non-small cell carcinoma (is_marker_for)

MLH1 ITGB1

4.19e-03169172DOID:3908 (is_marker_for)
Diseasegout

PRKCA PRDM8

5.59e-03196172EFO_0004274
DiseaseNeoplasm Metastasis

MLH1 ITGB1

6.81e-03217172C0027627
Diseasefat body mass

NCKAP5L ATG7

6.81e-03217172EFO_0005409

Protein segments in the cluster

PeptideGeneStartEntry
NKPSKLLDPPECGNG

ADAM22

436

Q9P0K1
KPAAAPKQPVGGGQK

NOLC1

401

Q14978
KKKGCPPDDIENPRG

ITGB1

71

P05556
KPDKGKGPPWADCGS

NCKAP5L

841

Q9HCH0
GKNLCPPASGGAKLN

PLXNA2

1166

O75051
GLKKPKQQGAGDLCP

ATG7

511

O95352
ENGGKDKPPQPGAKT

ELK4

121

P28324
KPEKPSLPKCGAQAG

DIDO1

446

Q9BTC0
KPGVEANPGPLNKDK

FAM90A20P

86

A6NIJ5
QPPFKPKVCGKGAEN

PRKCA

611

P17252
QQEAPLGPGPKFCKA

PRDM8

216

Q9NQV8
GPQNDGKQLCPPGKP

SSX3

131

Q99909
SDGKLKAPPKPCAGN

MLH1

131

P40692
GGSSKCKQPLPGPKG

CNK3/IPCEF1

366

G9CGD6
GGSSKCKQPLPGPKG

CNKSR3

366

Q6P9H4
PGKQGFKPKGPNPAA

ZNF341

266

Q9BYN7
GPQNDGKELCPPGKP

SSX2

131

Q16385
GPQNDGKKLCPPGKA

SSX6P

131

Q7RTT6
GLQNDGKQLCPPGKP

SSX9P

131

Q7RTT3
GKPQGEGKPASQAKP

TCEAL6

76

Q6IPX3
KPNKPKPCGLCNQFG

XRN2

256

Q9H0D6
GKPQGEGKPASQAKP

TCEAL3

76

Q969E4
PKKKGPVQPAGGQKG

TPGS2

261

Q68CL5
KAKCLSGEPGQPEGK

TXNRD3NB

86

Q6F5E7