Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Protein_Kinase_C_mu-related	PRKD3 PRKD2	1.41e-05	3	41	2	IPR015727
Domain	DAG/PE-bd	PRKD3 PRKD2	9.62e-04	21	41	2	IPR020454
Domain	Ser/Thr_kinase_AS	PRKD3 PRKD2 IRAK3 GAK PAK5	1.06e-03	357	41	5	IPR008271
Domain	PROTEIN_KINASE_ST	PRKD3 PRKD2 IRAK3 GAK PAK5	1.12e-03	362	41	5	PS00108
Domain	Pkinase	PRKD3 PRKD2 IRAK3 GAK PAK5	1.41e-03	381	41	5	PF00069
Domain	PH	PRKD3 PRKD2 PLCG2 KIF1A	1.56e-03	229	41	4	PF00169
Domain	PH	PRKD3 PRKD2 PLCG2 KIF1A	3.16e-03	278	41	4	SM00233
Domain	PROTEIN_KINASE_ATP	PRKD3 PRKD2 IRAK3 GAK PAK5	3.17e-03	459	41	5	PS00107
Domain	PH_DOMAIN	PRKD3 PRKD2 PLCG2 KIF1A	3.20e-03	279	41	4	PS50003
Domain	PH_domain	PRKD3 PRKD2 PLCG2 KIF1A	3.24e-03	280	41	4	IPR001849
Domain	Prot_kinase_dom	PRKD3 PRKD2 IRAK3 GAK PAK5	4.15e-03	489	41	5	IPR000719
Domain	PROTEIN_KINASE_DOM	PRKD3 PRKD2 IRAK3 GAK PAK5	4.30e-03	493	41	5	PS50011
Domain	SH3_1	PLCG2 FUT8 PACSIN2	5.55e-03	164	41	3	PF00018
Domain	Kinase-like_dom	PRKD3 PRKD2 IRAK3 GAK PAK5	6.39e-03	542	41	5	IPR011009
Domain	C1_1	PRKD3 PRKD2	6.95e-03	57	41	2	PF00130
Domain	FN3	KIAA0319 IL2RG TNN	7.73e-03	185	41	3	SM00060
Domain	S_TKc	PRKD3 PRKD2 GAK PAK5	7.76e-03	359	41	4	SM00220
Domain	ZF_DAG_PE_1	PRKD3 PRKD2	8.70e-03	64	41	2	PS00479
Domain	ZF_DAG_PE_2	PRKD3 PRKD2	8.70e-03	64	41	2	PS50081
Domain	C1	PRKD3 PRKD2	8.96e-03	65	41	2	SM00109
Domain	PE/DAG-bd	PRKD3 PRKD2	9.23e-03	66	41	2	IPR002219
Domain	HTH_motif	DLX1 DLX3	1.01e-02	69	41	2	IPR000047
Domain	-	PRKD3 PRKD2 PLCG2 KIF1A	1.04e-02	391	41	4	2.30.29.30
Domain	FN3_dom	KIAA0319 IL2RG TNN	1.08e-02	209	41	3	IPR003961
Pubmed	Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.	PRKD3 PRKD2	1.49e-06	2	43	2	24840177
Pubmed	Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.	PRKD3 PRKD2	1.49e-06	2	43	2	30841931
Pubmed	Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.	PRKD3 PRKD2	1.49e-06	2	43	2	25802335
Pubmed	Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis.	HABP2 F5	1.49e-06	2	43	2	12578864
Pubmed	Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.	PRKD3 PRKD2	1.49e-06	2	43	2	23393329
Pubmed	Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.	PRKD3 PRKD2	1.49e-06	2	43	2	37044359
Pubmed	Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a.	HABP2 C5	1.49e-06	2	43	2	22308306
Pubmed	Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V.	C5 F5	1.49e-06	2	43	2	8900278
Pubmed	Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.	PRKD3 PRKD2	4.48e-06	3	43	2	26253275
Pubmed	Following the development of a CD4 T cell response in vivo: from activation to memory formation.	C5 IL2RG	4.48e-06	3	43	2	10485651
Pubmed	Expression of the protein kinase D (PKD) family during mouse embryogenesis.	PRKD3 PRKD2	4.48e-06	3	43	2	16377259
Pubmed	A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.	PRKD3 PRKD2	4.48e-06	3	43	2	27662904
Pubmed	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	PRKD3 PRKD2	4.48e-06	3	43	2	32747433
Pubmed	Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.	PRKD3 PRKD2	4.48e-06	3	43	2	26426580
Pubmed	Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells.	C5 IL2RG	4.48e-06	3	43	2	12707300
Pubmed	Histone deacetylase 5 is a phosphorylation substrate of protein kinase D in osteoclasts.	PRKD3 HDAC4	4.48e-06	3	43	2	35318161
Pubmed	DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.	IL2RG DNMT1	4.48e-06	3	43	2	25908435
Pubmed	Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation.	C5 IL2RG	4.48e-06	3	43	2	12543861
Pubmed	Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.	PRKD3 PRKD2	4.48e-06	3	43	2	38419169
Pubmed	Large-scale concatenation cDNA sequencing.	FAM216A HDAC4 FUT8 KIF1A SAMD14 EML4 PACSIN2	5.78e-06	568	43	7	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	FAM216A HDAC4 FUT8 KIF1A SAMD14 EML4 PACSIN2	6.19e-06	574	43	7	8619474
Pubmed	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	PRKD3 PRKD2	8.94e-06	4	43	2	14743217
Pubmed	Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.	PRKD3 PRKD2	8.94e-06	4	43	2	27670070
Pubmed	Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.	PRKD2 PLCG2	8.94e-06	4	43	2	37616163
Pubmed	The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.	PLCG2 IL2RG	8.94e-06	4	43	2	35142046
Pubmed	The evolution of the vertebrate Dlx gene family.	DLX1 DLX3	1.49e-05	5	43	2	8855272
Pubmed	Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice.	C5 IL2RG	1.49e-05	5	43	2	24973440
Pubmed	Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.	C5 PTGS1	1.49e-05	5	43	2	11017920
Pubmed	Protein kinase D regulates RhoA activity via rhotekin phosphorylation.	PRKD3 PRKD2	1.49e-05	5	43	2	22228765
Pubmed	Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.	IL2RG DNMT1	1.49e-05	5	43	2	27197203
Pubmed	Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.	DLX1 DLX3	1.49e-05	5	43	2	9187081
Pubmed	Expression of Dlx genes during the development of the murine dentition.	DLX1 DLX3	2.23e-05	6	43	2	11180832
Pubmed	Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family.	DLX1 DLX3	2.23e-05	6	43	2	11069141
Pubmed	Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.	C5 IL2RG	2.23e-05	6	43	2	35840625
Pubmed	Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.	DLX1 DLX3	3.12e-05	7	43	2	17164413
Pubmed	Uncoupling of Natural Killer cell functional maturation and cytolytic function in NOD mice.	C5 IL2RG	3.12e-05	7	43	2	37536708
Pubmed	Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.	DLX1 DLX3	4.16e-05	8	43	2	11358480
Pubmed	Roles for Msx and Dlx homeoproteins in vertebrate development.	DLX1 DLX3	4.16e-05	8	43	2	10773441
Pubmed	High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial.	F5 PTGS1	4.16e-05	8	43	2	19530321
Pubmed	p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK binding.	HDAC4 CCNB1	4.16e-05	8	43	2	16082198
Pubmed	Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells.	C5 CCNB1	5.35e-05	9	43	2	19162005
Pubmed	Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.	C5 PTGS1	6.68e-05	10	43	2	10051620
Pubmed	Dlx and other homeobox genes in the morphological development of the dentition.	DLX1 DLX3	6.68e-05	10	43	2	7554933
Pubmed	Distal-less and other homeobox genes in the development of the dentition.	DLX1 DLX3	6.68e-05	10	43	2	7964557
Pubmed	Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.	DLX1 DLX3	9.78e-05	12	43	2	15053981
Pubmed	Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation.	DLX1 DLX3	9.78e-05	12	43	2	10021349
Pubmed	Gene polymorphisms implicated in influencing susceptibility to venous and arterial thromboembolism: frequency distribution in a healthy German population.	HABP2 F5	1.15e-04	13	43	2	17003923
Pubmed	Pax6 regulates the identity of embryonic diencephalic neurons.	DLX1 DLX3	1.15e-04	13	43	2	11161479
Pubmed	Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus.	DLX1 DLX3	1.15e-04	13	43	2	12799141
Pubmed	Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity.	C5 IL2RG	1.15e-04	13	43	2	38833371
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PRKD3 PRKD2 IRAK3 GAK EML4 PAK5 CCNB1	1.16e-04	910	43	7	36736316
Pubmed	Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone.	DLX1 DLX3	1.35e-04	14	43	2	17182777
Pubmed	GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.	PRKD2 IL2RG	1.55e-04	15	43	2	23345428
Pubmed	Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.	DNMT1 CCNB1	1.55e-04	15	43	2	27030811
Pubmed	Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders.	HABP2 F5	1.77e-04	16	43	2	20532885
Pubmed	A role for the mesenchymal T-box gene Brachyury in AER formation during limb development.	DLX1 DLX3	1.77e-04	16	43	2	12588849
Pubmed	Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.	DLX1 DLX3	1.77e-04	16	43	2	19121383
Pubmed	MOZ directs the distal-less homeobox gene expression program during craniofacial development.	DLX1 DLX3	2.01e-04	17	43	2	31340933
Pubmed	The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance.	DNMT1 CCNB1	2.26e-04	18	43	2	36178098
Pubmed	Requirement for Mab21l2 during development of murine retina and ventral body wall.	DLX1 DLX3	2.52e-04	19	43	2	15385160
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	LARP4B GAK DDHD1 PACSIN2 STT3A DNMT1	2.69e-04	733	43	6	34672954
Pubmed	The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction.	DLX1 DLX3	2.80e-04	20	43	2	21237142
Pubmed	AP-2α and AP-2β cooperatively orchestrate homeobox gene expression during branchial arch patterning.	DLX1 DLX3	3.40e-04	22	43	2	29229773
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKD3 PLCG2	4.05e-04	24	43	2	10843712
Pubmed	Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.	PRKD3 C5	4.05e-04	24	43	2	19706712
Pubmed	Defining the membrane proteome of NK cells.	LARP4B GAK FUT8 IL2RG F5 EML4 STT3A	5.30e-04	1168	43	7	19946888
Pubmed	SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.	DNMT1 CCNB1	5.53e-04	28	43	2	34163012
Pubmed	Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.	PRKD2 PTGS1	5.93e-04	29	43	2	24003143
Pubmed	Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.	DLX3 F5	8.17e-04	34	43	2	12878157
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	HEATR5A CCDC191 FAM135A	9.05e-04	153	43	3	10718198
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LARP4B FUT8 KIF1A STT3A DNMT1 CCNB1	1.01e-03	942	43	6	31073040
Pubmed	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.	PRKD3 PLCG2	1.02e-03	38	43	2	12482669
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PRKD2 GAK FUT8 KIF1A STT3A CCNB1	1.20e-03	974	43	6	28675297
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	F5 PTGS1 DNMT1	1.23e-03	170	43	3	19064572
Cytoband	2p21	PRKD3 EML4	1.51e-03	61	43	2	2p21
Cytoband	2q37.3	HDAC4 KIF1A	2.40e-03	77	43	2	2q37.3
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PRKD3 PRKD2 KIF1A	3.49e-03	206	27	3	682
GeneFamily	NKL subclass homeoboxes and pseudogenes	DLX1 DLX3	4.47e-03	67	27	2	519
Coexpression	GSE22611_UNSTIM_VS_2H_MDP_STIM_MUTANT_NOD2_TRANSDUCED_HEK293T_CELL_DN	LARP4B GAK PLCG2 EML4 DDHD1	1.32e-05	186	43	5	M8175
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 HABP2 ATP6V1C2 PLCG2 PAK5	8.03e-07	179	43	5	27ad6a609fe1f7532b142d0147bccf918704a6dd
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	9.26e-06	137	43	4	81cdb216e6c81acf9c2072f9d39e1a42612e1258
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCG2 SAMD14 DNAH5 PTGS1	1.43e-05	153	43	4	3b1b0cc8e9dd2b1484649789330713282ee44414
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	1.58e-05	157	43	4	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	1.71e-05	160	43	4	86fde32f096eaf9ea3677f57169cdcc0a57bb8dd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	1.93e-05	165	43	4	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.02e-05	167	43	4	166b7b4ca0663cde6d88219ee0bcc1988d03dab8
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIAA0319 ATP6V1C2 KIF1A F5	2.07e-05	168	43	4	4e1b522c7400c9d87f63c00e4e1dd07136095cd6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.37e-05	174	43	4	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.42e-05	175	43	4	98947a226b5a2ac7091ff9d34243ea7736add973
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCG2 SAMD14 DNAH5 PTGS1	2.42e-05	175	43	4	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.42e-05	175	43	4	77c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.48e-05	176	43	4	25ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.48e-05	176	43	4	c2c4306476989bc2fb30dab00250ef7915842f13
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	2.53e-05	177	43	4	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLCG2 SAMD14 DNAH5 PTGS1	2.59e-05	178	43	4	09a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	F5 FAM135A DDHD1 CCNB1	2.71e-05	180	43	4	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg\|bone_marrow / Manually curated celltypes from each tissue	DLX1 SAMD14 PTGS1 CCNB1	2.71e-05	180	43	4	44ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCell	HSPCs-Eo/Baso_prog.\|HSPCs / Lineage and Cell class	PRKD3 IRAK3 FUT8 IL2RG	3.01e-05	185	43	4	1ae29c0077bfc57e8896e59a21f20af43e7ff5b7
ToppCell	HSPCs-Eo/Baso_prog.\|World / Lineage and Cell class	PRKD3 IRAK3 FUT8 IL2RG	3.01e-05	185	43	4	b40ea11f5e536438b400ca5fddfd4559789036bd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	3.14e-05	187	43	4	7b0168bdaa7c6c6b39878aff6a17f0943189a380
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 PAK5	3.34e-05	190	43	4	bb3b396d78887d5d6f93a05c8ed4d703591bf33f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHOC1 ATP6V1C2 PLCG2 HDAC4	3.34e-05	190	43	4	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHOC1 PLCG2 DNAH5 CCDC191	3.63e-05	194	43	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
Drug	norathyriol	PRKD3 PRKD2 PLCG2 PTGS1	6.96e-07	37	43	4	CID005281656
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; HL60; HT_HG-U133A	PRKD3 DKC1 IRAK3 FAM216A PLCG2 CCNB1	1.26e-06	185	43	6	1833_DN
Drug	D 609	PRKD3 PRKD2 PLCG2 PTGS1	6.45e-06	64	43	4	CID000002940
Drug	AC1L1JGQ	PRKD3 PRKD2 GAK PLCG2	1.09e-05	73	43	4	CID000005034
Drug	ilmofosine	PRKD3 PRKD2 CCNB1	1.78e-05	27	43	3	CID000055008
Drug	N,N-dimethyl-D-erythro-sphingosine	PRKD3 PRKD2 C5 PLCG2	1.82e-05	83	43	4	CID000004285
Drug	AG213	PRKD3 PRKD2 PLCG2 PTGS1	2.40e-05	89	43	4	CID005328803
Drug	AC1L3G0K	PRKD3 PRKD2 PLCG2	2.46e-05	30	43	3	CID000114822
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	EXTL3 SLCO1C1 IL2RG F5 PTGS1	2.93e-05	191	43	5	3976_DN
Drug	NSC618487	PRKD3 PRKD2 GAK PLCG2 IL2RG PTGS1 STT3A PAK5 CCNB1	5.03e-05	933	43	9	CID000005279
Drug	poly(C,U	IL2RG CCNB1	5.20e-05	6	43	2	CID000168536
Drug	RHC 80267	PRKD3 PRKD2 PLCG2 PTGS1	5.91e-05	112	43	4	CID000005063
Drug	PEP005	PRKD3 PRKD2 IRAK3	6.84e-05	42	43	3	CID006918670
Drug	methylthiourea	PTGS1 DNMT1	7.27e-05	7	43	2	CID002723704
Drug	propacetamol	F5 PTGS1	7.27e-05	7	43	2	CID000068865
Drug	romidepsin	HDAC4 PTGS1 CCNB1	7.87e-05	44	43	3	ctd:C087123
Drug	myricitrin	PRKD3 PRKD2 PTGS1	8.42e-05	45	43	3	CID005281673
Drug	3,4,5-trimethoxybenzoic acid	PRKD3 PRKD2 STT3A	9.60e-05	47	43	3	CID000008357
Drug	AC1L1DKK	PRKD3 PRKD2 PLCG2 IL2RG	9.63e-05	127	43	4	CID000002390
Drug	6-trans-leukotriene B4	PRKD3 PRKD2 C5 PLCG2 PTGS1	9.92e-05	247	43	5	CID000000169
Drug	15-epi-lipoxin A4	PRKD3 PRKD2 C5 PTGS1	9.92e-05	128	43	4	CID000003934
Disease	coagulation factor V measurement	DLX3 F5 PAK5	2.59e-06	20	40	3	EFO_0008087
Disease	hereditary sensory neuropathy (is_implicated_in)	KIF1A DNMT1	1.07e-05	4	40	2	DOID:0050548 (is_implicated_in)
Disease	Thrombophilia due to thrombin defect	HABP2 F5	4.99e-05	8	40	2	cv:C3160733
Disease	stem Cell Factor measurement	CYB5RL PLCG2 F5	1.04e-04	67	40	3	EFO_0008291
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	PLCG2 F5	3.70e-04	21	40	2	EFO_0004286, EFO_0004792
Disease	venous thromboembolism, tissue plasminogen activator measurement	PLCG2 F5	4.45e-04	23	40	2	EFO_0004286, EFO_0004791
Disease	factor XI measurement, venous thromboembolism	PLCG2 F5	7.61e-04	30	40	2	EFO_0004286, EFO_0004694
Disease	factor VIII measurement, venous thromboembolism	PLCG2 F5	9.78e-04	34	40	2	EFO_0004286, EFO_0004630
Disease	endometrial carcinoma (is_marker_for)	PTGS1 CCNB1	9.78e-04	34	40	2	DOID:2871 (is_marker_for)
Disease	Schizophrenia	DLX1 HDAC4 FUT8 IL2RG PTGS1 DNMT1	1.14e-03	883	40	6	C0036341
Disease	venous thromboembolism, factor VII measurement	PLCG2 F5	1.22e-03	38	40	2	EFO_0004286, EFO_0004619

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPASYHADINLLYWS	DNMT1	1031	P26358
SYTSWYPSAHQEAMQ	DLX1	236	P56177
YTWSNTYVFPKEDSN	CC2D2B	1031	Q6DHV5
PSYLDDPTNSWYHAQ	DLX3	241	O60479
VWYESPSLGSHSTYK	RBFA	56	Q8N0V3
SYKWTHQQPSDSDLY	RBM11	186	P57052
KWEYQRASSSSPLDY	PAK5	216	Q9P286
SSDPRYWYGKTQHSS	HDAC4	196	P56524
YWYGKTQHSSLDQSS	HDAC4	201	P56524
SEVSSYSSKYAPHSW	MAGEE1	726	Q9HCI5
KNYQEHWSQYESTKS	JHY	326	Q6NUN7
YSLITPQTWSATHSY	LARP4B	356	Q92615
YNFTSSISWYESSPK	FAM135A	1186	Q9P2D6
SSEQLPWSYQEKTHF	CYB5RL	251	Q6IPT4
YSVDKSLSHPWLQEY	PRKD2	796	Q9BZL6
YSVDKSLSHPWLQDY	PRKD3	821	O94806
TSSSSKHLWYMPEEY	IRAK3	331	Q9Y616
NPLSHYWISSSHNTY	PLCG2	316	P16885
PPTYNSAHDYISWES	PTGS1	126	P23219
SSYEKTQSYPTDWSD	PACSIN2	386	Q9UNF0
TTISHYPDYSWSAQR	GAK	196	O14976
SSTLTHAENPDWYYT	HABP2	56	Q14520
WTPTLQHYLSYTEES	CCNB1	361	P14635
AETSENAKLHYYNSW	HEATR5A	1481	Q86XA9
PHQSWLYNSNYSCEL	EXTL3	781	O43909
SQSYLYIDWTDNHKA	C5	461	P01031
YHELYQQSDTWSLSK	CCDC191	916	Q8NCU4
QPTNLTLHYWYKNSD	IL2RG	81	P31785
SSYITHLDWSPDNKY	EML4	721	Q9HC35
YSNISPVQIHWYNTS	DDHD1	676	Q8NEL9
SSRYSQKQHYPCTTW	FAM216A	156	Q8WUB2
DSTPATWKQEYVDYS	DKC1	406	O60832
HWNTRTQEYLYPSDT	DNAH5	2541	Q8TE73
YWSHTSPEDINYASQ	KIF1A	56	Q12756
YPNYEFISDNSISWS	FUT8	421	Q9BYC5
PNYSQWQKTYESLSD	ATP6V1C2	191	Q8NEY4
QPNSSYTYVWHATER	F5	1701	P12259
EHQPTTWSSYYFDLQ	STT3A	351	P46977
PVTSYNQTSYWKDSS	SHOC1	1181	Q5VXU9
WQEAKCSYPYHTLSQ	SAMD14	296	Q8IZD0
SPQEGTVTWKTYHTY	ABCC12	771	Q96J65
PESQLSHLYGWDKYS	nan	91	Q8NFD4
SWEPSSQVDHYLLSY	TNN	281	Q9UQP3
ENYTTSDHLLQPNYW	SLCO1C1	691	Q9NYB5
TTYNYEWNLISHPTD	KIAA0319	366	Q5VV43