Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	ERCC3 MDN1 ATP7B IPO8 DYNC2H1 GPN1 KIF16B SMC4 SMARCA4 MCM2 ARID1A DNAH14 HSP90AB1	6.82e-07	614	78	13	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	ERCC3 MDN1 ATP7B DYNC2H1 GPN1 KIF16B SMC4 SMARCA4 MCM2 HSP90AB1	8.21e-06	441	78	10	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ERCC3 MDN1 ATP7B GBP5 DYNC2H1 GPN1 KIF16B SMC4 SMARCA4 MCM2 GBP3 HSP90AB1	4.43e-05	775	78	12	GO:0017111
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	8.99e-05	4	78	2	GO:0047696
GeneOntologyMolecularFunction	pyrophosphatase activity	ERCC3 MDN1 ATP7B GBP5 DYNC2H1 GPN1 KIF16B SMC4 SMARCA4 MCM2 GBP3 HSP90AB1	9.47e-05	839	78	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ERCC3 MDN1 ATP7B GBP5 DYNC2H1 GPN1 KIF16B SMC4 SMARCA4 MCM2 GBP3 HSP90AB1	9.57e-05	840	78	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ERCC3 MDN1 ATP7B GBP5 DYNC2H1 GPN1 KIF16B SMC4 SMARCA4 MCM2 GBP3 HSP90AB1	9.57e-05	840	78	12	GO:0016818
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK3	3.12e-04	7	78	2	GO:0004703
GeneOntologyMolecularFunction	ATP-dependent protein binding	PLK2 HSP90AB1	8.10e-04	11	78	2	GO:0043008
MousePheno	abnormal coronary artery morphology	DYNC2H1 SMARCA4 PLXND1 RYR1	6.72e-06	29	60	4	MP:0004111
Domain	P-loop_NTPase	ERCC3 MDN1 GBP5 DYNC2H1 SULT1C3 GPN1 KIF16B SMC4 SMARCA4 MCM2 GBP3 DNAH14 CASK EHD2	9.70e-06	848	78	14	IPR027417
Domain	-	ERCC3 MDN1 GBP5 DYNC2H1 SULT1C3 GPN1 SMC4 SMARCA4 MCM2 GBP3 DNAH14 CASK EHD2	1.19e-05	746	78	13	3.40.50.300
Domain	GST_mu	GSTM1 GSTM5	1.71e-04	5	78	2	IPR003081
Domain	FHA	SNIP1 KIF16B AGGF1	2.13e-04	28	78	3	SM00240
Domain	FHA_DOMAIN	SNIP1 KIF16B AGGF1	2.90e-04	31	78	3	PS50006
Domain	FHA	SNIP1 KIF16B AGGF1	2.90e-04	31	78	3	PF00498
Domain	GPCR_kinase	GRK2 GRK3	3.57e-04	7	78	2	IPR000239
Domain	FHA_dom	SNIP1 KIF16B AGGF1	4.53e-04	36	78	3	IPR000253
Domain	-	SNIP1 KIF16B AGGF1	4.53e-04	36	78	3	2.60.200.20
Domain	GBP_C	GBP5 GBP3	7.58e-04	10	78	2	PF02841
Domain	G_GB1_RHD3_dom	GBP5 GBP3	9.24e-04	11	78	2	IPR030386
Domain	Guanylate-bd_C	GBP5 GBP3	9.24e-04	11	78	2	IPR003191
Domain	GBP	GBP5 GBP3	9.24e-04	11	78	2	PF02263
Domain	Guanylate-bd_N	GBP5 GBP3	9.24e-04	11	78	2	IPR015894
Domain	G_GB1_RHD3	GBP5 GBP3	9.24e-04	11	78	2	PS51715
Domain	SMAD_FHA_domain	SNIP1 KIF16B AGGF1	1.34e-03	52	78	3	IPR008984
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH14	1.52e-03	14	78	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH14	1.52e-03	14	78	2	IPR024743
Domain	MT	DYNC2H1 DNAH14	1.52e-03	14	78	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH14	1.52e-03	14	78	2	PF12780
Domain	ATPase_dyneun-rel_AAA	MDN1 DYNC2H1	1.52e-03	14	78	2	IPR011704
Domain	AAA_5	MDN1 DYNC2H1	1.52e-03	14	78	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH14	1.75e-03	15	78	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH14	1.75e-03	15	78	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH14	1.75e-03	15	78	2	PF03028
Domain	GST_N	GSTM1 GSTM5	3.77e-03	22	78	2	PF02798
Domain	GST_NTER	GSTM1 GSTM5	3.77e-03	22	78	2	PS50404
Domain	GST_C	GSTM1 GSTM5	5.24e-03	26	78	2	IPR004046
Domain	GST_C	GSTM1 GSTM5	5.24e-03	26	78	2	PF00043
Domain	Glutathione_S-Trfase_N	GSTM1 GSTM5	5.65e-03	27	78	2	IPR004045
Pubmed	Nucleolar proteome dynamics.	WBP11 GTF2F1 MDN1 SF3A3 SMARCA4 MCM2 EXOSC8 MPHOSPH10 UTP3 HSP90AB1	3.98e-08	419	79	10	15635413
Pubmed	The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.	SNIP1 SMARCA4 ARID1A NDUFB4 KRIT1	1.69e-07	55	79	5	35945219
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ANKRD36B MRPL23 PARP4 MDN1 AP1B1 DYNC2H1 KIF16B MPHOSPH10 NEB ARID1A RYR1	2.12e-07	638	79	11	31182584
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	ERCC3 AP1B1 SF3A3 SMARCA4 MPHOSPH10 UTP3 ARID1A KRIT1	2.06e-06	370	79	8	22922362
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	GTF2F1 MDN1 AP1B1 SF3A3 SMC4 SMARCA4 MCM2 CCDC144CP ARID1A NDUFAB1 HSP90AB1	3.35e-06	847	79	11	35235311
Pubmed	Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2).	GSTM1 GSTM5	5.09e-06	2	79	2	2689439
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	5.09e-06	2	79	2	8638670
Pubmed	Genomic organization and characterization of the promoter region of murine GSTM2 gene.	GSTM1 GSTM5	5.09e-06	2	79	2	11404019
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	5.09e-06	2	79	2	33060647
Pubmed	Tumor progression by epithelial-mesenchymal transition in ARID1A- and SMARCA4-aberrant solid-type poorly differentiated gastric adenocarcinoma.	SMARCA4 ARID1A	5.09e-06	2	79	2	34997313
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	5.09e-06	2	79	2	8035170
Pubmed	Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction.	GSTM1 GSTM5	5.09e-06	2	79	2	8909248
Pubmed	DNA methylation is associated with altered gene expression in AMD.	GSTM1 GSTM5	5.09e-06	2	79	2	22410570
Pubmed	GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.	GBP5 MAP3K14	5.09e-06	2	79	2	34958688
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	5.09e-06	2	79	2	10198406
Pubmed	Progesterone regulation of glutathione S-transferase Mu2 expression in mouse uterine luminal epithelium during preimplantation period.	GSTM1 GSTM5	5.09e-06	2	79	2	18692819
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	5.09e-06	2	79	2	11762794
Pubmed	Lethal multiple pterygium syndrome, large cystic hygroma, and cleft palate: Rare and severe fetal presentations of RYR1- and NEB-related congenital myopathies.	NEB RYR1	5.09e-06	2	79	2	38520674
Pubmed	GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.	GSTM1 GSTM5	5.09e-06	2	79	2	25897651
Pubmed	Mass spectrometric analysis of the phosphorylation levels of the SWI/SNF chromatin remodeling/tumor suppressor proteins ARID1A and Brg1 in ovarian clear cell adenocarcinoma cell lines.	SMARCA4 ARID1A	5.09e-06	2	79	2	25083560
Pubmed	Coffin-Siris syndrome in two chinese patients with novel pathogenic variants of ARID1A and SMARCA4.	SMARCA4 ARID1A	5.09e-06	2	79	2	35353340
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ERCC3 TRIM25 SMARCA4 MCM2 MPHOSPH10 UTP3 ZFC3H1 ARID1A	7.33e-06	440	79	8	34244565
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	GSTM1 GSTM5 DPYS SRCIN1 ZFC3H1	1.01e-05	125	79	5	17062627
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SNIP1 WBP11 SMC4 SMARCA4 MCM2 EXOSC8 ARID1A CLASRP	1.16e-05	469	79	8	27634302
Pubmed	Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.	GRK2 GRK3	1.53e-05	3	79	2	10754297
Pubmed	Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.	SMARCA4 ARID1A	1.53e-05	3	79	2	36464671
Pubmed	Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.	GSTM1 GSTM5	1.53e-05	3	79	2	8471052
Pubmed	Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.	GRK2 GRK3	1.53e-05	3	79	2	10085131
Pubmed	Purification and characterization of glutathione S-transferase of murine ovary and testis.	GSTM1 GSTM5	1.53e-05	3	79	2	8442656
Pubmed	Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.	GRK2 GRK3	1.53e-05	3	79	2	7761854
Pubmed	The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.	GRK2 GRK3	1.53e-05	3	79	2	31604529
Pubmed	Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.	GSTM1 GSTM5	1.53e-05	3	79	2	32574561
Pubmed	Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.	GRK2 GRK3	1.53e-05	3	79	2	12130708
Pubmed	Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion.	GSTM1 GSTM5	1.53e-05	3	79	2	9452477
Pubmed	Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.	SMARCA4 ARID1A	1.53e-05	3	79	2	11780067
Pubmed	SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity.	SMARCA4 ARID1A	1.53e-05	3	79	2	33075803
Pubmed	Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.	SMARCA4 ARID1A	1.53e-05	3	79	2	22426308
Pubmed	ARID1A, BRG1, and INI1 deficiency in undifferentiated and dedifferentiated endometrial carcinoma: a clinicopathologic, immunohistochemical, and next-generation sequencing analysis of a case series from a single institution.	SMARCA4 ARID1A	1.53e-05	3	79	2	36252860
Pubmed	A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5.	GSTM1 GSTM5	1.53e-05	3	79	2	8473333
Pubmed	ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.	SMARCA4 ARID1A	1.53e-05	3	79	2	21900401
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MRPL23 MDN1 DOCK9 GPN1 SMC4 SRCIN1 UTP3 NEB	1.76e-05	497	79	8	36774506
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	INTU WBP11 MDN1 CEP83 SMC4 MPHOSPH10 ZFC3H1 NEB ARID1A NDUFAB1 NDUFB4 LYST HSP90AB1	2.09e-05	1442	79	13	35575683
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MRPL23 MDN1 SF3A3 SMC4 SMARCA4 MCM2 EXOSC8 MPHOSPH10 UTP3 ZFC3H1	2.20e-05	847	79	10	35850772
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	MDN1 SF3A3 SMARCA4 MCM2 ARID1A	2.68e-05	153	79	5	26365490
Pubmed	Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.	SMARCA4 ARID1A	3.05e-05	4	79	2	31906887
Pubmed	Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.	GRK2 GRK3	3.05e-05	4	79	2	21784156
Pubmed	SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development.	SMARCA4 ARID1A	3.05e-05	4	79	2	22621927
Pubmed	The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers.	SMARCA4 ARID1A	3.05e-05	4	79	2	28262751
Pubmed	Efficiency assessment of the gene trap approach.	RAPGEF1 HSP90AB1	3.05e-05	4	79	2	9626493
Pubmed	p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.	GSTM1 GSTM5	3.05e-05	4	79	2	17292829
Pubmed	The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor.	GSTM1 GSTM5	3.05e-05	4	79	2	22406107
Pubmed	Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.	GRK2 GRK3	3.05e-05	4	79	2	8917529
Pubmed	Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.	GSTM1 GSTM5	3.05e-05	4	79	2	8317488
Pubmed	Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins.	SMARCA4 ARID1A	3.05e-05	4	79	2	28863077
Pubmed	Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.	GRK2 GRK3	3.05e-05	4	79	2	8662816
Pubmed	Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.	GBP5 GBP3	3.05e-05	4	79	2	38404575
Pubmed	Two related ARID family proteins are alternative subunits of human SWI/SNF complexes.	SMARCA4 ARID1A	3.05e-05	4	79	2	15170388
Pubmed	Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.	SMARCA4 ARID1A	3.05e-05	4	79	2	11988099
Pubmed	Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.	GRK2 GRK3	3.05e-05	4	79	2	23734232
Pubmed	Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex.	SMARCA4 ARID1A	3.05e-05	4	79	2	17878164
Pubmed	The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes.	SMARCA4 ARID1A	3.05e-05	4	79	2	33481850
Pubmed	Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SMARCB1, SMARCA4, SMARCE1, and ARID1A.	SMARCA4 ARID1A	3.05e-05	4	79	2	25168959
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SNIP1 GTF2F1 ERCC3 TRIM25 MDN1 CEP83 SMC4 EXOSC8 MPHOSPH10 UTP3 ZFC3H1 NDUFB4 CASK	3.09e-05	1497	79	13	31527615
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	MDN1 SMC4 SMARCA4 ARID1A	3.25e-05	79	79	4	26446488
Pubmed	Genetic link between renal birth defects and congenital heart disease.	AP1B1 DYNC2H1 PLXND1	3.55e-05	28	79	3	27002738
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	GPN1 MCM2 MPHOSPH10 ZFC3H1 HSP90AB1	3.62e-05	163	79	5	22113938
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAK3 MDN1 SZT2 LONRF1 DOCK9 RAPGEF1 EXOSC8 PLXND1 ARID1A LYST RYR1	3.97e-05	1105	79	11	35748872
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	WBP11 IPO8 ARHGEF10 DOCK9 SMC4 SMARCA4 MCM2 NCAM2 FAM13B CASK	4.26e-05	916	79	10	32203420
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	MRPL23 GTF2F1 SF3A3 SMARCA4 MPHOSPH10 UTP3 ZCCHC7	4.67e-05	417	79	7	36537216
Pubmed	Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.	GRK2 GRK3	5.07e-05	5	79	2	10338466
Pubmed	Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.	GBP5 GBP3	5.07e-05	5	79	2	12396730
Pubmed	Unique features of different members of the human guanylate-binding protein family.	GBP5 GBP3	5.07e-05	5	79	2	17266443
Pubmed	The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo.	SMARCA4 ARID1A	5.07e-05	5	79	2	18086889
Pubmed	p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.	SMARCA4 ARID1A	5.07e-05	5	79	2	9584200
Pubmed	Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.	SMARCA4 ARID1A	5.07e-05	5	79	2	12200431
Pubmed	Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.	GBP5 GBP3	5.07e-05	5	79	2	21151871
Pubmed	Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma.	SMARCA4 ARID1A	5.07e-05	5	79	2	28202515
Pubmed	Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1.	GSTM1 GSTM5	5.07e-05	5	79	2	19856098
Pubmed	Glutathione S-transferase variants and hypertension.	GSTM1 GSTM5	5.07e-05	5	79	2	18551009
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	PARP4 MDN1 AP1B1 SF3A3 SMC4 SMARCA4 ARID1A HSP90AB1	5.39e-05	582	79	8	20467437
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ERCC3 MDN1 IPO8 SMARCA4 AGGF1 EXOSC8 MPHOSPH10 UTP3 ZFC3H1	5.64e-05	759	79	9	35915203
Pubmed	CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.	WBP11 GTF2F1 MDN1 CASK	6.44e-05	94	79	4	37468549
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	ANKRD36B DYNC2H1 KRT82 ZFC3H1 HSP90AB1	6.96e-05	187	79	5	26460568
Pubmed	Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.	SMARCA4 ARID1A	7.60e-05	6	79	2	16940996
Pubmed	beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.	GRK2 GRK3	7.60e-05	6	79	2	9826657
Pubmed	Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.	GRK2 GRK3	7.60e-05	6	79	2	20074556
Pubmed	The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest.	SMARCA4 ARID1A	7.60e-05	6	79	2	16230384
Pubmed	Numerous BAF complex genes are mutated in Coffin-Siris syndrome.	SMARCA4 ARID1A	7.60e-05	6	79	2	25081545
Pubmed	ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.	SMARCA4 ARID1A	7.60e-05	6	79	2	29604291
Pubmed	Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.	GRK2 GRK3	7.60e-05	6	79	2	36451830
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	MRPL23 WBP11 GTF2F1 TRIM25 UBE2H AP1B1 GPN1 SF3A3 SMC4 SMARCA4 MCM2 HSP90AB1	8.07e-05	1415	79	12	28515276
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	AP1B1 DYNC2H1 SMARCA4 PLXND1	8.19e-05	100	79	4	25807483
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	MRPL23 SNIP1 GBP5 KIF16B SF3A3 SMARCA4 MCM2 ARID1A NDUFAB1 NDUFB4 HSP90AB1 EHD2	1.02e-04	1451	79	12	30550785
Pubmed	BRIT1/MCPH1 links chromatin remodelling to DNA damage response.	SMARCA4 MCM2	1.06e-04	7	79	2	19525936
Pubmed	Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.	SMARCA4 ARID1A	1.06e-04	7	79	2	23540691
Pubmed	Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.	SMARCA4 HSP90AB1	1.06e-04	7	79	2	20353823
Pubmed	Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system.	GSTM1 GSTM5	1.06e-04	7	79	2	8584275
Pubmed	Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.	GRK2 GRK3	1.06e-04	7	79	2	8672451
Pubmed	Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.	GRK2 GRK3	1.06e-04	7	79	2	11517230
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GSTM1 ERCC3 TRIM25 SF3A3 SMC4 SMARCA4 EXOSC8 MPHOSPH10 UTP3 ZFC3H1 HSP90AB1	1.25e-04	1257	79	11	36526897
Interaction	SNRNP40 interactions	SNIP1 WBP11 GTF2F1 UBE2H SF3A3 SMARCA4 AGGF1 MPHOSPH10 UTP3 ZFC3H1 ZCCHC7 ARID1A CLASRP	1.08e-06	637	79	13	int:SNRNP40
Interaction	MTHFD1 interactions	MRPL23 SNIP1 DCUN1D1 TRIM25 UBE2H DYNC2H1 MCM2 HSP90AB1	1.36e-05	279	79	8	int:MTHFD1
Interaction	MYPN interactions	TRIM25 MCM2 NEB RYR1	1.80e-05	40	79	4	int:MYPN
Interaction	CCM2 interactions	SNIP1 TRIM25 KRIT1 HSP90AB1	2.19e-05	42	79	4	int:CCM2
Interaction	RPL23A interactions	MRPL23 SNIP1 GTF2F1 DCUN1D1 TRIM25 IPO8 UBE2H MCM2 MPHOSPH10 UTP3 ZFC3H1	2.35e-05	606	79	11	int:RPL23A
Interaction	GLRX interactions	TRIM25 ATP7B UBE2H MCM2	2.88e-05	45	79	4	int:GLRX
Interaction	MAGED2 interactions	JAK3 INTU TRIM25 UBE2H MAP3K14 MCM2 HSP90AB1	4.71e-05	243	79	7	int:MAGED2
Interaction	FBXO22 interactions	MRPL23 TRIM25 MDN1 UBE2H DOCK9 GPN1 SMC4 SRCIN1 UTP3 NEB	4.81e-05	540	79	10	int:FBXO22
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	COL24A1 GBP5 GBP3 SPATA1	9.59e-05	137	79	4	chr1p22
Cytoband	1p22.3	COL24A1 SPATA1	6.60e-04	22	79	2	1p22.3
Cytoband	1p22.2	GBP5 GBP3	1.07e-03	28	79	2	1p22.2
Disease	muscle measurement	PLK2 NEB	3.71e-05	4	74	2	EFO_0004515
Disease	Brugada syndrome (implicated_via_orthology)	GSTM1 GSTM5	6.17e-05	5	74	2	DOID:0050451 (implicated_via_orthology)
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	SMARCA4 ARID1A	6.17e-05	5	74	2	C3281201
Disease	MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE	NEB RYR1	9.25e-05	6	74	2	C1854678
Disease	asphyxiating thoracic dystrophy (is_implicated_in)	INTU DYNC2H1	1.29e-04	7	74	2	DOID:0050592 (is_implicated_in)
Disease	peanut allergy measurement, parental genotype effect measurement	ADGB RYR1	3.36e-04	11	74	2	EFO_0005939, EFO_0007017
Disease	Congenital myopathy (disorder)	NEB RYR1	4.03e-04	12	74	2	C0270960
Disease	osteitis deformans	GSTM5 DPYS	4.75e-04	13	74	2	EFO_0004261
Disease	Coffin-Siris syndrome	SMARCA4 ARID1A	4.75e-04	13	74	2	C0265338
Disease	respiratory quotient	INTU NDUFB4	5.54e-04	14	74	2	EFO_0005189
Disease	autism spectrum disorder (implicated_via_orthology)	GSTM1 GSTM5 ARHGEF10 CASK	5.89e-04	152	74	4	DOID:0060041 (implicated_via_orthology)
Disease	Burkitt Leukemia	SMARCA4 ARID1A	6.38e-04	15	74	2	C4721444
Disease	African Burkitt's lymphoma	SMARCA4 ARID1A	6.38e-04	15	74	2	C0343640
Disease	level of Sterol ester (27:1/18:1) in blood serum	SMARCA4 CLASRP	7.28e-04	16	74	2	OBA_2045195
Disease	multiple sclerosis (is_implicated_in)	GSTM1 APOC2 HSP90AB1	8.30e-04	73	74	3	DOID:2377 (is_implicated_in)
Disease	intrahepatic cholangiocarcinoma (is_marker_for)	ARID1A HSP90AB1	1.03e-03	19	74	2	DOID:4928 (is_marker_for)
Disease	QRS duration, response to sulfonylurea	MDN1 DOCK9	1.52e-03	23	74	2	EFO_0005055, EFO_0007922
Disease	level of Sterol ester (27:1/18:2) in blood serum	SMARCA4 CLASRP	1.94e-03	26	74	2	OBA_2045194
Disease	level of Sterol ester (27:1/16:0) in blood serum	SMARCA4 CLASRP	1.94e-03	26	74	2	OBA_2045191
Disease	non-high density lipoprotein cholesterol measurement	GSTM5 COLEC11 PLK2 ZZZ3 SMARCA4 DTX3L ARID1A	2.07e-03	713	74	7	EFO_0005689
Disease	Sezary Syndrome	SMARCA4 ARID1A	2.09e-03	27	74	2	C0036920
Disease	blood strontium measurement	PLK2 GPR158	2.09e-03	27	74	2	EFO_0021531
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	COLEC11 PLK2 SMARCA4 ARID1A	2.46e-03	224	74	4	EFO_0004530, EFO_0008317

Protein segments in the cluster

Peptide	Gene	Start	Entry
YVDALKRILEQYEKP	ARHGEF10	436	O15013
PQVKFYEEIKEYEKL	GRK3	81	P35626
KTYLPAVDEKLRDLY	APOC2	61	P02655
KEIRDYYIPNDKKIL	ADGB	1106	Q8N7X0
LQLKCYKKPDLERYE	ATP7B	1371	P35670
VEYLVRKKHIYIPKN	GOT1L1	361	Q8NHS2
KELYRTKLLPLEEHY	EHD2	26	Q9NZN4
DRVLYVLKLYDKIDP	NDUFAB1	81	O14561
YEDEKTLKNPKYKDR	AGGF1	576	Q8N302
IVVIKDIFRKYPNKY	AP1B1	411	Q10567
LIYEYKRKRYEDLPI	ANKRD36B	236	Q8N2N9
TKLERYKELYLEEVK	CCDC144CP	1081	Q8IYA2
KEEYARILDEGKIKY	CEP83	166	Q9Y592
DRKKLEQLYNRYKDP	DCUN1D1	61	Q96GG9
PLVEFYEEIKKYEKL	GRK2	81	P25098
DFEKIKPVEYRLQYK	KIF16B	891	Q96L93
KTVEPLEYYRRFLKE	EXOSC8	6	Q96B26
AKLLPLDKDYYVVRE	JAK3	971	P52333
PQEVLKKYIIYAKER	MCM2	716	P49736
RKPLDLYRLYVSVKE	ARID1A	1046	O14497
LKERDRYAYKIHLPE	CASK	276	O14936
YPITLYLEKEREKEI	HSP90AB1	211	P08238
FDPAVKREYKLNYVK	MDN1	3241	Q9NU22
KYLEELPEKLKLYSE	GSTM5	126	P46439
DELKKLYAQLEIYKR	GPR158	716	Q5T848
KYLPDELSERKKIYD	LONRF1	541	Q17RB8
KPFAEYIYKRIKQRD	DPYS	466	Q14117
DRVPVLEEYREYKKI	FAM13B	881	Q9NYF5
IIETKKNYYKRIEPA	NAA50	131	Q9GZZ1
KLLYAKEIPEYRKIV	PLXND1	1821	Q9Y4D7
KEIPEYRKIVQRYYK	PLXND1	1826	Q9Y4D7
KKKIREYYRLLNVEE	DNAJC28	46	Q9NX36
VVRKEKPKEDAYEYK	MPHOSPH10	441	O00566
LKEAINKPYEKVRIY	KRIT1	411	O00522
QKLQDLEKKYYEEPR	GBP3	436	Q9H0R5
QKTEELKAKYYREPR	GBP5	436	Q96PP8
LEGYKKKYEEELSLR	KRT82	201	Q9NSB4
IREKRLLDVKNYDPY	PARP4	81	Q9UKK3
IYYIIKTERDRKEKL	NDUFB4	101	O95168
EREYRPEYERLKKSL	GPN1	266	Q9HCN4
IIEDDYKERKKYEPK	INTU	96	Q9ULD6
YRPKDCERLVLYLKD	DYNC2H1	2346	Q8NCM8
DIYKLIIPIYEKRRD	DOCK9	1736	Q9BZ29
YPDPSYLKRVKEELK	DTX3L	721	Q8TDB6
LLYLDKEDKVYLKLE	CBLN4	166	Q9NTU7
SKIYLLVKEEKRYAD	COLEC11	151	Q9BWP8
KPRLLRYEEKKYEDV	DNAH14	201	Q0VDD8
RYEEKKYEDVKPLET	DNAH14	206	Q0VDD8
LKYLALEEKLYKDPR	DRC7	851	Q8IY82
KPIAVQYKEKEDRYV	LYST	3191	Q99698
PEFYREYVAIKTKKR	ERCC3	516	P19447
KLFTPEEYEEYKRKV	FAM221A	31	A4D161
EEYEEYKRKVLPLRL	FAM221A	36	A4D161
LKYYKEIEDRQKLKR	UTP3	376	Q9NQZ2
LRPYKTFSEKDKEIY	RYR1	2791	P21817
LLTEKLKPVDYEYRE	MAP3K14	381	Q99558
LVKTYEYKKAEEREP	IPO8	156	O15397
RKKYGIVLKEFRPED	GTF2F1	81	P35269
LDKLLIRYEKLPLDY	SZT2	746	Q5T011
NKRIEPQRYYELKEK	SNIP1	341	Q8TAD8
PQRYYELKEKDVLKF	SNIP1	346	Q8TAD8
RILYLFYEDIKKDPK	SULT1C3	196	Q6IMI6
KYLEELPEKLKLYSE	GSTM1	126	P09488
EYYELIRKPVDFKKI	SMARCA4	1496	P51532
TKLREDLELYYKKLL	SPATA1	361	Q5VX52
RREYYEKIKKDPAQF	CLASRP	26	Q8N2M8
EVQKLPHLKTERKYY	COL24A1	1691	Q17RW2
LHRPEEYKQKIKEYI	UBE2H	131	P62256
APILEYIVKYRSKDK	NCAM2	621	O15394
DRSIIKIYRKEPLYA	SRCIN1	251	Q9C0H9
ELIKKLQYRYEKFSP	RAPGEF1	731	Q13905
AKSRPELLEYYIKVI	TRIM25	446	Q14258
RIKKPDYKVAYVQLA	MRPL23	86	Q16540
YEEVKLYKNAREREK	VPS28	21	Q9UK41
YKKKEELYLQRVAEL	SMC4	1096	Q9NTJ3
YDDKYEIQEREKRLK	ZCCHC7	381	Q8N3Z6
FDIPKERKNAEYKRY	SF3A3	171	Q12874
LKARKVLTEPEVRYY	PLK2	171	Q9NYY3
RILRLYEKENPDIYK	WBP11	91	Q9Y2W2
YEKENPDIYKELRKL	WBP11	96	Q9Y2W2
PDIYKELRKLEVEYE	WBP11	101	Q9Y2W2
DLVIYLEQRKEPYKV	ZNF732	51	B4DXR9
YRNLPEYKELLQFKK	ZZZ3	786	Q8IYH5
KRRLQKLEYEYALKI	ZFC3H1	966	O60293
REEYEKFKALYTLPR	NEB	4741	P20929