Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-galactosidase activity

GLA NAGA

1.83e-052862GO:0004557
GeneOntologyMolecularFunctionoxidoreductase activity

NLRP11 KDM4D NDUFAF5 KDM4C RRM2B TECR CYP26C1 AKR7A3 LIPF CAT IDH2 PLOD2 AKR7A2

2.31e-057668613GO:0016491
GeneOntologyMolecularFunctionphenanthrene-9,10-epoxide hydrolase activity

AKR7A3 AKR7A2

5.48e-053862GO:0019119
GeneOntologyMolecularFunctionphenanthrene-epoxide hydrolase activity

AKR7A3 AKR7A2

5.48e-053862GO:0019118
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP8B3 ABCA1 ABCA3 ANO1

6.87e-0551864GO:0140303
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP8B3 ABCA1 ABCA3

2.34e-0428863GO:0140326
GeneOntologyMolecularFunctionhistone H3K9me2/H3K9me3 demethylase activity

KDM4D KDM4C

2.72e-046862GO:0140684
GeneOntologyMolecularFunctionphospholipid transporter activity

ATP8B3 ABCA1 ABCA3 ANO1

2.93e-0474864GO:0005548
GeneOntologyMolecularFunctiongalactosidase activity

GLA NAGA

3.80e-047862GO:0015925
GeneOntologyMolecularFunctionphosphatidylserine floppase activity

ATP8B3 ABCA1

6.47e-049862GO:0090556
GeneOntologyMolecularFunctionglycine transmembrane transporter activity

SLC7A8 SLC6A9

8.07e-0410862GO:0015187
GeneOntologyMolecularFunctionepoxide hydrolase activity

AKR7A3 AKR7A2

9.83e-0411862GO:0004301
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC7A8 SLC6A9 ABCA1 ABCA3 SLC12A2 IPO8 SLC35E3 SLC15A3

1.04e-03477868GO:0022804
GeneOntologyMolecularFunctionhydrolase activity, acting on ether bonds

AKR7A3 AKR7A2

1.39e-0313862GO:0016801
GeneOntologyMolecularFunctionether hydrolase activity

AKR7A3 AKR7A2

1.39e-0313862GO:0016803
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

NLRP11 KDM4D KDM4C CYP26C1 PLOD2

1.52e-03194865GO:0016705
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR7A3 AKR7A2

1.61e-0314862GO:0004032
GeneOntologyMolecularFunctionhistone H3K9 demethylase activity

KDM4D KDM4C

1.61e-0314862GO:0032454
GeneOntologyMolecularFunctionfloppase activity

ATP8B3 ABCA1

2.12e-0316862GO:0140328
DomainGlyco_hydro_27/36_CS

GLA NAGA

2.00e-052842IPR000111
DomainALPHA_GALACTOSIDASE

GLA NAGA

2.00e-052842PS00512
DomainMelibiase_2

GLA NAGA

2.00e-052842PF16499
DomainGlyco_hydro_27

GLA NAGA

2.00e-052842IPR002241
DomainCse1

IPO8 IPO7

5.98e-053842IPR013713
DomainCse1

IPO8 IPO7

5.98e-053842PF08506
DomainJmjN

KDM4D KDM4C

8.79e-0410842SM00545
DomainJMJN

KDM4D KDM4C

8.79e-0410842PS51183
DomainJmjN

KDM4D KDM4C

8.79e-0410842PF02375
DomainJmjN

KDM4D KDM4C

8.79e-0410842IPR003349
DomainABC_A

ABCA1 ABCA3

1.28e-0312842IPR026082
Domain-

GLA NAGA

1.76e-03148422.60.40.1180
DomainIMPORTIN_B_NT

IPO8 IPO7

1.76e-0314842PS50166
DomainGlyco_hydro_b

GLA NAGA

2.02e-0315842IPR013780
DomainIBN_N

IPO8 IPO7

2.02e-0315842PF03810
DomainLaminin_N

LAMA1 NTN1

2.30e-0316842IPR008211
DomainIBN_N

IPO8 IPO7

2.30e-0316842SM00913
DomainLAMININ_NTER

LAMA1 NTN1

2.30e-0316842PS51117
DomainLaminin_N

LAMA1 NTN1

2.30e-0316842PF00055
Domain-

AKR7A3 AKR7A2

2.30e-03168423.20.20.100
DomainLamNT

LAMA1 NTN1

2.30e-0316842SM00136
DomainNADP_OxRdtase_dom

AKR7A3 AKR7A2

2.60e-0317842IPR023210
DomainC345C

C3 NTN1

2.60e-0317842SM00643
DomainAldo_ket_red

AKR7A3 AKR7A2

2.60e-0317842PF00248
DomainAldo/ket_red/Kv-b

AKR7A3 AKR7A2

2.60e-0317842IPR001395
DomainImportin-beta_N

IPO8 IPO7

2.60e-0317842IPR001494
DomainNTR

C3 NTN1

3.25e-0319842PF01759
DomainNetrin_module_non-TIMP

C3 NTN1

3.25e-0319842IPR018933
DomainARM-type_fold

DOCK2 IPO8 PSME4 IPO7 PIK3CB AGBL1

4.24e-03339846IPR016024
DomainAA-permease/SLC12A_dom

SLC7A8 SLC12A2

4.36e-0322842IPR004841
DomainEPHD

JADE3 KDM4C

4.36e-0322842PS51805
DomainAA_permease

SLC7A8 SLC12A2

4.36e-0322842PF00324
DomainNTR

C3 NTN1

4.76e-0323842PS50189
DomainNetrin_domain

C3 NTN1

4.76e-0323842IPR001134
DomainJmjC

KDM4D KDM4C

5.17e-0324842PF02373
Domain-

GYG2 EXT2 PLOD2

5.82e-03818433.90.550.10
DomainTIMP-like_OB-fold

C3 NTN1

6.06e-0326842IPR008993
DomainTPR_REGION

NAA25 TTC17 TTC39A TTC22

6.55e-03165844PS50293
DomainTPR

NAA25 TTC17 TTC39A TTC22

6.55e-03165844PS50005
DomainSH3_2

DOCK2 MYO7B ZDHHC6

6.87e-0386843IPR011511
DomainSH3_2

DOCK2 MYO7B ZDHHC6

6.87e-0386843PF07653
DomainNucleotide-diphossugar_trans

GYG2 EXT2 PLOD2

7.32e-0388843IPR029044
DomainARM-like

DOCK2 IPO8 PSME4 IPO7 AGBL1

7.43e-03270845IPR011989
Pubmed

C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast.

LAMA1 C3

6.48e-0628923488995
Pubmed

A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post-Golgi compartments.

ABCA1 ABCA3

6.48e-06289221586796
Pubmed

Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation.

GLA F5

6.48e-06289216514103
Pubmed

Increased Expression of the ABCA1 and ABCA3 Transporter Genes is Associated with Cisplatin Resistance in Breast Cancer Cells.

ABCA1 ABCA3

6.48e-06289238019257
Pubmed

Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases.

GLA NAGA

6.48e-06289220444686
Pubmed

Expression of the lipid transporters ABCA3 and ABCA1 is diminished in human breast cancer tissue.

ABCA1 ABCA3

6.48e-06289219902402
Pubmed

Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease.

GLA NAGA

6.48e-06289219853240
Pubmed

[Synergistic effect of deficiency in thrombosis-related genes].

GLA F5

6.48e-06289220533258
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

GLA SLC12A2 SPCS1 ZDHHC6 ATP6AP2 NAGA LAMA1 ELOVL5 TTC17 EXT2 PLOD2 CPVL DNASE2

1.15e-051201891335696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

NAA25 SLC12A2 IPO8 IPO7 SPCS1 ATP6AP2 TECR CAT EXT2 QARS1 APOBEC3B FOXG1 TOP2B

1.17e-051203891329180619
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

TRHDE GLA ATP6AP2 NAGA AKR7A3 TMPRSS2 C3 CAT IDH2 CPVL DNASE2 AKR7A2

1.82e-051070891223533145
Pubmed

[Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].

AKR7A3 AKR7A2

1.94e-05389222863590
Pubmed

Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.

AKR7A3 AKR7A2

1.94e-05389212123834
Pubmed

Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.

AKR7A3 AKR7A2

1.94e-05389224590062
Pubmed

Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.

AKR7A3 AKR7A2

1.94e-05389212071861
Pubmed

Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.

AKR7A3 AKR7A2

1.94e-05389216919859
Pubmed

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

ABCA1 TOP2B

1.94e-05389223466610
Pubmed

Preferential utilization of Imp7/8 in nuclear import of Smads.

IPO8 IPO7

1.94e-05389218519565
Pubmed

AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.

AKR7A3 AKR7A2

1.94e-05389239365156
Pubmed

Diversity within the JMJD2 histone demethylase family.

KDM4D KDM4C

1.94e-05389217207460
Pubmed

Endocochlear potential depends on Cl- channels: mechanism underlying deafness in Bartter syndrome IV.

SLC12A2 FOXG1

1.94e-05389218833191
Pubmed

Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation.

ABCA1 ABCA3

1.94e-05389228241820
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

GLA IPO7 SPCS1 ATP6AP2 TECR C3 CAT TTC17 EXT2 QARS1 PLOD2 DNASE2 AKR7A2

2.57e-051297891333545068
Pubmed

Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.

AKR7A3 AKR7A2

3.87e-05489212879023
Pubmed

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.

LAMA1 PLOD2

3.87e-05489216467571
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

IPO8 IPO7 TECR CAPN2 SNX27 C3 CAT IDH2 QARS1

4.27e-0564789926618866
Pubmed

Cystathionine γ-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway.

ABCA1 PIK3CB

6.44e-05589226772887
Pubmed

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol.

ABCA1 ABCA3

6.44e-05589217142808
Pubmed

Early uneven ear input induces long-lasting differences in left-right motor function.

SLC12A2 FOXG1

6.44e-05589229534062
Pubmed

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

KDM4D KDM4C

6.44e-05589221914792
Pubmed

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.

KDM4D KDM4C

6.44e-05589216738407
Pubmed

A novel class of RanGTP binding proteins.

IPO8 IPO7

6.44e-0558929214382
Pubmed

A causative link between inner ear defects and long-term striatal dysfunction.

SLC12A2 FOXG1

6.44e-05589224009395
Pubmed

Identification and characterization of JMJD2 family genes in silico.

KDM4D KDM4C

9.65e-05689215138608
Pubmed

Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice.

NTN1 FOXG1

9.65e-05689223971992
Pubmed

Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta.

FOXG1 TOP2B

9.65e-05689212773624
Pubmed

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

SLC12A2 ATP6AP2 CAPN2 ANO1 TMPRSS2 EXT2 PLOD2

1.00e-0441789719199708
Pubmed

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

IPO8 IPO7

1.35e-04789211682607
Pubmed

Rb/E2F regulates expression of neogenin during neuronal migration.

NTN1 FOXG1

1.35e-04789221059867
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NAA25 GLA SLC12A2 IPO7 ATP6AP2 TECR CAPN2 EXT2 QARS1 PLOD2

1.49e-04942891031073040
Pubmed

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

ABCA1 ABCA3

1.79e-04889224293640
Pubmed

Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

IPO8 IPO7

1.79e-04889227114554
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

IPO8 IPO7 ATP6AP2 TECR CAPN2 SNX27 C3 TTC17 EXT2 CPVL

1.95e-04974891028675297
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

NAGA SNX27 C3 CAT IDH2 F5 TOP2B

2.23e-0447589731040226
Pubmed

Hmx2 homeobox gene control of murine vestibular morphogenesis.

NTN1 FOXG1

2.30e-04989211748138
Pubmed

Genetic interactions support an inhibitory relationship between bone morphogenetic protein 2 and netrin 1 during semicircular canal formation.

NTN1 FOXG1

2.30e-04989230770380
Pubmed

Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.

LAMA1 C3

2.30e-0498928661125
Pubmed

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

SLC12A2 ANO1

2.88e-041089227721237
Pubmed

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

TECR ELOVL5

2.88e-041089220937905
Pubmed

Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space.

NTN1 FOXG1

2.88e-041089220652952
Pubmed

The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain.

NTN1 FOXG1

2.88e-041089210601035
Pubmed

Calcium signaling induces partial EMT and renal fibrosis in a Wnt4mCherry knock-in mouse model.

COL10A1 PIEZO2 SLC12A2

3.46e-045389338653356
Pubmed

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.

KDM4D KDM4C

3.51e-041189219144645
Pubmed

Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.

IPO7 TECR

3.51e-041189235842443
Pubmed

Genome-wide atlas of gene expression in the adult mouse brain.

CLIC4 NTN1 FOXG1

3.66e-045489317151600
Pubmed

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.

CAPN2 C3 F5

4.07e-045689337059927
Pubmed

The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.

AKR7A3 AKR7A2

4.20e-041289210495887
Pubmed

Mice deficient in Ext2 lack heparan sulfate and develop exostoses.

COL10A1 EXT2

4.96e-041389216236767
Pubmed

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.

NTN1 FOXG1

4.96e-04138928565836
Pubmed

Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.

TRIM22 TOP2B

5.78e-041489219902255
Pubmed

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

COL10A1 C3

5.78e-041489221665990
Pubmed

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.

KDM4D KDM4C

5.78e-041489216603238
Pubmed

Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.

LIMK2 PIK3CB

5.78e-041489220041213
Pubmed

Floor-plate-derived netrin-1 is dispensable for commissural axon guidance.

NTN1 FOXG1

5.78e-041489228445456
Pubmed

Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.

CAT F5

5.78e-041489220078877
Pubmed

Identification of genes expressed in the mouse limb using a novel ZPA microarray approach.

ANO1 NTN1

6.65e-041589217911046
Pubmed

A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.

LAMA1 FOXG1

6.65e-041589228535372
Pubmed

Multiple roles for Pax2 in the embryonic mouse eye.

NTN1 FOXG1

6.65e-041589233428890
Pubmed

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

ABCA1 C3

6.65e-041589220385826
Pubmed

Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.

NTN1 FOXG1

6.65e-04158929226455
Pubmed

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

IPO7 SPCS1 ATP6AP2 ATP5MJ TOP2B

6.74e-0427189525737280
Pubmed

Identification of cAMP analogue inducible genes in RAW264 macrophages.

ABCA1 SLC15A3

7.59e-041689211004510
Pubmed

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

NTN1 FOXG1

7.59e-04168928543157
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

TRHDE GLA TECR PLOD2

8.52e-0416489432409323
Pubmed

Dual origins of the mammalian accessory olfactory bulb revealed by an evolutionarily conserved migratory stream.

NTN1 FOXG1

8.59e-041789223292680
Pubmed

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

ABCA1 C3

8.59e-041789220385819
Pubmed

Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress.

SLC12A2 CAT

8.59e-041789239048051
Pubmed

PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly.

SNX27 CAT

8.59e-041789229117568
Pubmed

Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope.

PIEZO2 APOBEC3B

9.65e-041889237914931
Pubmed

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

C3 CAT EXT2

9.95e-047689319336475
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

GLA IPO7 NAGA TTC17 PLOD2 CPVL DNASE2

1.01e-0361389722268729
Pubmed

Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.

MYO7B FOXG1

1.08e-031989234124068
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

GLA IPO7 ZNF75D CAT QARS1 PLOD2

1.08e-0345189636168627
Pubmed

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.

IPO8 ELOVL5 C3 CAT IDH2 PLOD2

1.10e-0345389627113764
Pubmed

CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.

CYP26C1 FOXG1

1.19e-032089217067568
Pubmed

Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.

AKR7A3 AKR7A2

1.19e-03208929828140
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

IPO8 IPO7 PIK3CB TECR

1.28e-0318389423956138
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM4D KDM4C

1.32e-032189227626377
Pubmed

Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx.

NTN1 FOXG1

1.32e-032189215363417
Pubmed

Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.

NTN1 FOXG1

1.45e-032289222726835
Pubmed

Differences in health status affect susceptibility and mapping of genetic loci for atherosclerosis (fatty streak) in inbred mice.

SLC12A2 CPVL

1.45e-032289222837474
Pubmed

Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.

ABCA3 IPO8

1.58e-032389210708515
Pubmed

Perioperative genomic profiles using structure-specific oligonucleotide probes.

ABCA1 F5

1.58e-032389219474452
Pubmed

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin.

COL10A1 PIEZO2

1.72e-032489232186512
Pubmed

An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.

SNX27 CPVL

1.87e-032589237589075
Pubmed

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia.

PIEZO2 LAMA1

1.87e-032589235681537
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

GLA IPO7 SNX27 C3 CAT

1.94e-0334489530333137
Pubmed

Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.

CAT F5

2.02e-032689221054877
Pubmed

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.

SLC6A9 FOXG1

2.02e-032689226651292
Pubmed

Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.

COL10A1 PIK3CB

2.02e-032689221367821
InteractionTMEM106B interactions

GLA SPCS1 ATP6AP2 TECR TMPRSS2 C3 TTC17 EXT2 PLOD2

5.07e-06309839int:TMEM106B
GeneFamilyATP binding cassette subfamily A

ABCA1 ABCA3

1.06e-0314632805
GeneFamilyAldo-keto reductases

AKR7A3 AKR7A2

1.22e-0315632399
GeneFamilyArmadillo repeat containing|Importins

IPO8 IPO7

1.76e-0318632596
GeneFamilySolute carriers

SLC7A8 SLC6A9 SLC12A2 SLC35E3 SLC15A3 SLC44A3

2.49e-03395636752
GeneFamilyPHD finger proteins|Lysine demethylases

KDM4D KDM4C

3.14e-0324632485
CoexpressionGSE24634_TREG_VS_TCONV_POST_DAY3_IL4_CONVERSION_DN

ABCA1 GLA NAGA SNX27 CAT TTC17 SLC15A3

5.10e-06200887M4600
CoexpressionESC_V6.5_UP_EARLY.V1_DN

KLK10 MYO7B CAPN2 LAMA1 NTN1 SULT1E1

1.88e-05163886M2769
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK2 GLA CAT SLC15A3 CPVL DNASE2

1.46e-061788860b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellControl-Epithelial_alveolar-AT_2-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 CAT TTC39A SLC44A3

1.66e-06182886e97681a4102f3095d5d9e90ad70f1dc46e90983a
ToppCellControl-Epithelial_alveolar-AT_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 CAT TTC39A SLC44A3

1.77e-0618488651e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCelldroplet-Fat-SCAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 IPO7 ANO1 TMPRSS2 CADPS2 SLC44A3

1.94e-061878865fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCelldroplet-Fat-SCAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 IPO7 ANO1 TMPRSS2 CADPS2 SLC44A3

1.94e-06187886766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCelldroplet-Fat-SCAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 IPO7 ANO1 TMPRSS2 CADPS2 SLC44A3

1.94e-06187886f49d06600060deeb2fc1b1da5b93496535f20104
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

ABCA3 TMPRSS2 C3 TTC39A CADPS2 AGBL1

2.07e-06189886dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellPND14-Epithelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABCA3 SLC12A2 OSBPL6 TMPRSS2 C3 CAT

2.13e-06190886f1eeef8f201bf7b96c020c8ab53dd7e05b3060ea
ToppCelldroplet-Fat-Scat-18m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SLC12A2 ANO1 TMPRSS2 TTC22 SLC44A3

2.26e-061928864098b5170c9995718758a082d1b8bcb86d5a289e
ToppCelldroplet-Fat-Scat-18m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SLC12A2 ANO1 TMPRSS2 TTC22 SLC44A3

2.26e-06192886936028fe851e8dd2b906df0210acc574c017b499
ToppCelldroplet-Fat-Scat-18m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SLC12A2 ANO1 TMPRSS2 TTC22 SLC44A3

2.26e-0619288662e55ed0d46b2e7b07dc42399972a099576cbc5f
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

ABCA3 TMPRSS2 C3 TTC39A CADPS2 AGBL1

2.33e-06193886738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ABCA3 C3 CAT TTC39A ODC1 CADPS2

2.63e-06197886ad6f047d003c08413264f39a30ba0f7639a257cd
ToppCellControl_saline-Epithelial_alveolar-AT_2-AT2|Control_saline / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT TTC39A SLC44A3

2.63e-06197886f870a26f322668781e3d2832c5d9ef2c7c91011f
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NAGA SNX27 CAT SLC15A3 CPVL F5

2.86e-062008869e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

CARF BUB1 SLC35E3 F5 SLC44A3

2.09e-051688851bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

CARF BUB1 SLC35E3 F5 SLC44A3

2.09e-0516888569f534de0f9a293047bea03cb1b78551087a8df5
ToppCellEpithelial-Epithelial-C_(AT2)|Epithelial / shred on cell class and cell subclass (v4)

ABCA3 SLC12A2 C3 CAT PRRG3

2.40e-05173885f57cbf5bd2a9e5db47b4919e9cd5e50781c1a990
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A8 MYO7B SLC35E3 ODC1 AKR7A2

2.68e-051778859c7c6824b9011363851f084a500d665f025b026e
ToppCellfacs-Kidney-nan-24m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A8 MYO7B SLC35E3 ODC1 AKR7A2

2.68e-051778852bf639e9e801e5144462ffc957f5739e0dfcd500
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JADE3 ANO1 TMPRSS2 CPVL SLC44A3

2.83e-0517988588dbec952507d84b85b08165eec80df99ed1e736
ToppCellfacs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JADE3 ANO1 TMPRSS2 CPVL SLC44A3

2.83e-05179885daf8189a22786171e2b629261cf720736aa4ebdb
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

KLK10 HS3ST5 GYG2 NTN1 CADPS2

2.90e-05180885b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellControl-Epithelial_alveolar-AT_1-AT1-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKR7A3 TMPRSS2 HS3ST5 C3 PLOD2

3.06e-05182885a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SLC12A2 TMPRSS2 TTC39A PWWP3B

3.14e-051838857eaa6ef7c6cf848fd6489f97677f4406318da22f
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 TTC39A CADPS2

3.14e-05183885e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 HS3ST5 C3 CADPS2

3.22e-0518488542ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

ABCA3 TMPRSS2 C3 CADPS2 AGBL1

3.22e-05184885369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 C3 CAT TTC39A ODC1

3.22e-05184885157a3d00165bb4a8c52c3e63ae57d9cf57500be7
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GLA C3 CPVL APOBEC3B DNASE2

3.22e-0518488597ae5ffecf90df42cc8eea2a247ca589f35a4783
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 CADPS2 SLC44A3

3.31e-051858850d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CARF BUB1 LIPF CLIC4 TTC39A

3.31e-05185885b4af9ae4c358b48357cb135b740266e1652d886a
ToppCellLPS_only-Epithelial_alveolar|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 TTC39A CADPS2

3.40e-05186885e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TMPRSS2 NTN1 CADPS2 AGBL1 SLC44A3

3.40e-051868852ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC7A8 C3 SLC15A3 CPVL DNASE2

3.40e-05186885c7e2134454ab5d0885050dd1bb3c3bd15bf497ac
ToppCellP15-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

OSBPL6 ANO1 TMPRSS2 PLOD2 SLC44A3

3.40e-05186885521e6e007bbae73e7328153aa170cf04ca3c1093
ToppCellP28-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

OSBPL6 ANO1 TMPRSS2 PLOD2 SLC44A3

3.48e-05187885a4b41904ba05eb76212c949fc3ac197f906c8351
ToppCellLPS-IL1RA-Epithelial_alveolar|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 CAT TTC39A

3.57e-051888856164d467b612767ceba15de34176bcc8e8c36ab8
ToppCell15-Distal-Epithelial-Secretory_progenitor|Distal / Age, Tissue, Lineage and Cell class

KLK10 TMPRSS2 NTN1 PWWP3B SLC44A3

3.57e-051888859a64fb07de611de38d6f24673feb3b81a5e85384
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

SLC6A9 ABCA3 C3 CADPS2 AGBL1

3.57e-05188885ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE PIK3CB CLIC4 CPVL DNAH7

3.66e-05189885904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 TMPRSS2 C3 CAT SLC44A3

3.66e-051898855f883ef4cc0383142d538ae61f4fb40dfdb8ef18
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABCA3 SLC12A2 C3 CAT PRRG3

3.76e-051908858ff8c586237cf15f930416710bcff45205fe6f70
ToppCellfacs-Large_Intestine-Distal|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6AP2 ANO1 TMPRSS2 CLIC4 TTC39A

3.76e-051908853964a8390522b61b73235151bb0a2ff36b856867
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

KLK10 HS3ST5 NTN1 PWWP3B CADPS2

3.85e-0519188523776c7302cead3881b39127398f3b3e0d27885e
ToppCellPND14-Epithelial-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABCA3 SLC12A2 C3 CAT PRRG3

3.85e-051918855f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABCA3 SLC12A2 C3 CAT PRRG3

3.85e-051918852f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABCA3 SLC12A2 C3 CAT PRRG3

3.85e-051918854ab3056f9af2a6caed39f32288562f480811cd7b
ToppCellPND03-Epithelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABCA3 OSBPL6 ANO1 TMPRSS2 SLC44A3

3.95e-05192885d8c23693f690d4d568585537bbfedda05d505b3d
ToppCellEpithelial|World / shred on cell class and cell subclass (v4)

ABCA3 OSBPL6 ANO1 TMPRSS2 SLC44A3

3.95e-0519288513a3553d9a7c78535679d23d454c63fd08f7d218
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

KLK10 HS3ST5 NTN1 PWWP3B CADPS2

4.05e-051938852bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

DOCK2 SLC7A8 ABCA1 CPVL MS4A4E

4.15e-05194885800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCelldroplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIEZO2 SLC12A2 ANO1 TMPRSS2 TTC39A

4.15e-05194885715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A8 ABCA1 NAGA SLC15A3 CPVL

4.25e-05195885c16479a10f5ca2e89aea1742dbc5cc4dc9f3ea88
ToppCellFibroblasts-DKK3+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

PIEZO2 CAPN2 NTN1 PRRG3 F5

4.36e-0519688524d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell11.5-Distal-Epithelial-Secretory_progenitor|Distal / Age, Tissue, Lineage and Cell class

KLK10 TMPRSS2 NTN1 PWWP3B SLC44A3

4.36e-051968852648d64b0e7b59ae78182d55f32699ceea37ff8d
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CADPS2 SLC44A3

4.46e-05197885b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK2 SLC7A8 ABCA1 CPVL MS4A4E

4.46e-0519788510190b877bf46ba2163d203df9dd3b498c66e52f
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CADPS2 SLC44A3

4.46e-0519788544a59dfb889577b3160a5b13ada1276771a00241
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_macrophage|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC7A8 ABCA1 SLC15A3 CPVL MS4A4E

4.46e-05197885e3349a381723393cd255f202afedd0c99037939b
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 ABCA1 ATP6AP2 SLC15A3 DNASE2

4.46e-0519788572775eb6c24cfb956436642ac9cd6e4d5c01ea5f
ToppCellMacrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

GLA NAGA SLC15A3 CPVL DNASE2

4.46e-05197885598fb7a9a8400af49d90807b3155d3cc1c34f505
ToppCellSmart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_macrophage-macrophage|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC7A8 ABCA1 SLC15A3 CPVL MS4A4E

4.46e-05197885e567886d69c6ea8dec87019c2ebc593793cb3107
ToppCellControl_saline-Epithelial_alveolar-AT_2|Control_saline / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT SLC44A3

4.46e-05197885b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ABCA3 C3 CAT TTC39A CADPS2

4.46e-051978851638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-stromal_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 ABCA1 ATP6AP2 SLC15A3 DNASE2

4.46e-05197885075044c17f1c52008cd3c292c15cbf485b50411e
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.57e-05198885d087e738d69ca9853553fde46d4e7a8906439d32
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC7A8 ABCA1 CLIC4 SLC15A3 CPVL

4.57e-05198885579a22199643440b98e381147779ced630d4ed66
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

KLK10 HS3ST5 NTN1 PWWP3B CADPS2

4.57e-051988855fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT ODC1

4.57e-051988856b6572deeca98ccb015f2aa3c5ce27de44445f74
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 ABCA1 SLC15A3 CPVL MS4A4E

4.57e-051988856a4161680b46b2c12353a693c403b5a4bb3da03f
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA3 SPCS1 C3 CAT ODC1

4.57e-05198885d12f37527399038a8f030b45b176bda5c7c8a7ad
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT SLC44A3

4.57e-051988858d9858dcb21f20d0c040b22a2cae543eaebd54bc
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA3 C3 CAT ODC1 CADPS2

4.57e-05198885c4e7512f0e1d115f2be8acae6048eda8b6b640b2
ToppCellLPS_anti-TNF-Epithelial_alveolar|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.57e-0519888553e9ed1b19cb26be58da0f37057caca0cdfaabeb
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ABCA3 C3 CAT TTC39A ODC1

4.57e-05198885d499dced27b0c0e21acfda2c20fa5c114f605085
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Myeloid-Microglia|GW26 / Sample Type, Dataset, Time_group, and Cell type.

DOCK2 SLC7A8 C3 SLC15A3 CPVL

4.57e-05198885c0d33629438504a1545e07f0e5af2e76f50fd55b
ToppCellControl_saline-Epithelial_alveolar-AT_1-2_Progenitor|Control_saline / Treatment groups by lineage, cell group, cell type

ABCA3 AKR7A3 TMPRSS2 C3 CAT

4.57e-05198885cd8a26de6c1cb9c42635146bb7220dd1b41ee97d
ToppCellLPS_only-Epithelial_alveolar|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.57e-05198885655df75b9692d815c7f6910275e1f684ac63bf62
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.57e-0519888582bcd44f8744e7e8477fbfd871a52f3d1a8b3adc
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Myeloid|GW26 / Sample Type, Dataset, Time_group, and Cell type.

DOCK2 SLC7A8 C3 SLC15A3 CPVL

4.57e-051988852b93995f66c7352acc25d6c71d025b847881dacd
ToppCell10x3'2.3-week_12-13-Myeloid_macrophage-stroma-stromal_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 ABCA1 ATP6AP2 SLC15A3 DNASE2

4.57e-051988859a89083280d4253f282300cdf1e61746d1f32407
ToppCellLPS_only-Epithelial_alveolar-AT_1-2_Progenitor|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.68e-051998853a0af1a13b1760f4213d87d0958dbe3bf3b9a42b
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK2 SLC7A8 ABCA1 CPVL MS4A4E

4.68e-05199885f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KLK10 TMPRSS2 HS3ST5 C3 PRRG3

4.68e-051998852b357cc08c425a58d45aa6c086101c8fff53e218
ToppCellLPS_IL1RA-Epithelial_alveolar|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.68e-051998855b140ac88ebc25ce397ae577e48f3e271faf46e7
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC7A8 ABCA1 CLIC4 SLC15A3 CPVL

4.68e-05199885c4fc638a8dad3a9b77634e8912a9326c8a2f11f5
ToppCellLPS_only-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT ODC1

4.68e-051998850447f8f53389fe7c6ddc04a97d86e74122ea16f4
ToppCellLPS_only-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.68e-051998857b21447bb39cdba37539a12cb475f463010fc23f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid-Microglia|GW23 / Sample Type, Dataset, Time_group, and Cell type.

DOCK2 SLC7A8 C3 SLC15A3 CPVL

4.68e-051998854ddfbcaa8054b69b3398d8c0d5fab8ae94805cb9
ToppCellASK454-Immune-B_cell|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

ABCA3 C3 CAT ODC1 CPVL

4.68e-05199885b9b0ae81b9e7e35023c73d3b936e88167461ba54
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 AKR7A3 TMPRSS2 C3 CAT

4.68e-05199885ccdde5d4bcc72f230a1dd2544ee7f4dfb98a5e80
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC7A8 ABCA1 CLIC4 SLC15A3 CPVL

4.68e-05199885697a9a58c0cdb77222700d029873355d37f6ab28
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Myeloid|GW23 / Sample Type, Dataset, Time_group, and Cell type.

DOCK2 SLC7A8 C3 SLC15A3 CPVL

4.68e-051998853ba48a4715d5e9387650aa97e0c5d7f7897bf380
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ABCA3 TMPRSS2 C3 CAT CADPS2

4.79e-05200885c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRHDE DOCK2 MYO7B SLC15A3 CPVL

4.79e-05200885a443e475e7a10c26a6173d1af961de6219e0e567
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NAGA SNX27 CAT CPVL F5

4.79e-05200885107a0665fb20247511a430178effd7630a619488
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / Treatment groups by lineage, cell group, cell type

ABCA3 AKR7A3 TMPRSS2 C3 CADPS2

4.79e-052008859a6ae40f3e17cd44ee5fd73260713b920aa2ea15
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC12A2 ANO1 TMPRSS2 CADPS2 SLC44A3

4.79e-052008850eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRHDE DOCK2 MYO7B SLC15A3 CPVL

4.79e-05200885ed785a6d08ca2b350dc3307b587eadfb2886d1f9
ComputationalOxidoreductases.

AKR7A3 IDH2 AKR7A2

6.15e-0515573MODULE_519
Drugchlordecone

C3 CAT ODC1 IDH2 FOXG1

5.49e-0667865CID000000299
DrugTerazosin hydrochloride [63590-64-7]; Up 200; 9.4uM; HL60; HT_HG-U133A

LIMK2 ABCA1 COL10A1 CARF SLC35E3 DNASE2 FOXG1

9.52e-061968672530_UP
Drug6,9,12-octadecatrienoic acid

GLA TECR IDH2 AKR7A2 SULT1E1

1.16e-0578865CID000003453
Drugliu

GLA PIK3CB RRM2B NTN1 CAT QARS1 FOXG1 TOP2B

1.25e-05285868CID015991562
DiseaseFabry disease (implicated_via_orthology)

GLA NAGA

7.82e-062832DOID:14499 (implicated_via_orthology)
DiseaseX-24462 measurement

AKR7A3 AKR7A2

2.34e-053832EFO_0800886
DiseaseSeizures

RRM2B NAGA SNX27 CAT IDH2 FOXG1

3.57e-05218836C0036572
Diseasesciatic neuropathy (biomarker_via_orthology)

CAPN2 C3 CAT QARS1

1.79e-0499834DOID:11446 (biomarker_via_orthology)
Diseasesensorineural hearing loss (biomarker_via_orthology)

SLC12A2 CAT

2.16e-048832DOID:10003 (biomarker_via_orthology)
Diseaseaflatoxin B1 aldehyde reductase member 2 measurement

AKR7A3 AKR7A2

2.16e-048832EFO_0020132
Diseasecataract (is_marker_for)

CRYBA1 CAT

2.78e-049832DOID:83 (is_marker_for)
Diseaseosteonecrosis (is_implicated_in)

CAT F5

3.47e-0410832DOID:10159 (is_implicated_in)
Disease3-hydroxypropylmercapturic acid measurement

TRHDE PIK3CB TMPRSS2 NTN1 CADPS2 AGBL1

4.82e-04352836EFO_0007014
Diseaserostral middle frontal gyrus volume measurement

NTN1 AGBL1

6.96e-0414832EFO_0010328
DiseaseMMR-related febrile seizures

CAPN2 AGBL1

8.02e-0415832EFO_0006519
Diseaseocular hypertension (biomarker_via_orthology)

CRYBA1 C3

1.03e-0317832DOID:9282 (biomarker_via_orthology)
DiseaseRenal Insufficiency

GLA IDH2

1.03e-0317832C1565489
DiseaseColorectal Neoplasms

ABCA1 ABCA3 BUB1 LAMA1 ODC1

1.12e-03277835C0009404
Diseasestem Cell Growth Factor beta measurement

PIEZO2 KDM4C F5

1.25e-0375833EFO_0008292
Diseaseoleoylcarnitine measurement

AKR7A3 AKR7A2

1.30e-0319832EFO_0021043
DiseaseKidney Failure

GLA IDH2

1.74e-0322832C0035078
Diseaselung adenocarcinoma (is_marker_for)

COL10A1 IDH2 PLOD2

1.80e-0385833DOID:3910 (is_marker_for)
Diseasepartial thromboplastin time

F5 AGBL1

2.07e-0324832EFO_0004310
DiseaseDegenerative polyarthritis

CLIC4 IDH2 PLOD2

2.32e-0393833C0029408
DiseaseOsteoarthrosis Deformans

CLIC4 IDH2 PLOD2

2.32e-0393833C0086743
Diseaseinflammatory biomarker measurement

PIEZO2 F5

2.43e-0326832EFO_0004872
Diseasewhite matter integrity, age at assessment

CARF NTN1

2.43e-0326832EFO_0004641, EFO_0008007

Protein segments in the cluster

PeptideGeneStartEntry
YLYPGWNMEKQRFLT

TRHDE

476

Q9UKU6
MNLYTVYIIKGYWPL

CHRM4

86

P08173
AQGRWVKTMEVYPYL

ERVPABLB-1

296

P60509
KSNGWILPTVYQGMY

AKR7A2

186

O43488
PKEMTGIWRYLTNAY

CLIC4

211

Q9Y696
GWILPTVYQGMYNAI

AKR7A3

161

O95154
MLSNKPWNYQIDYFG

BUB1

976

O43683
TGKYPSWTFYIQVMT

CAT

271

P04040
VYNEGQQFMPWYKFD

APOBEC3B

161

Q9UH17
GVMTWYIEAVFPGQY

ABCA1

836

O95477
FGKYPSLELQPWMYN

ABCA1

1371

O95477
PELVNMGQWKIRAYY

C3

196

P01024
MGQWKIRAYYENSPQ

C3

201

P01024
VLYGLVTWYMEAVFP

ABCA3

461

Q99758
LYMWPFQKPNYTEIR

GLA

206

P06280
NSVFIDWDVQMYYKP

ATP8B3

456

O60423
LQFYWVTGFPIQMPY

CC2D2B

1371

Q6DHV5
QWFYFKVSGMQAAIP

AGBL1

631

Q96MI9
IYKSMDYGRTWVPFQ

NTN1

161

O95631
WVPFQFYSTQCRKMY

NTN1

171

O95631
MLTGVPVYFLGVYWQ

SLC7A8

456

Q9UHI5
LPISYEGQYIWNMLF

NLRP11

56

P59045
TFPLGWLYFQIGYMI

ELOVL5

226

Q9NYP7
KKRYTVVGNPYWMAP

LIMK2

501

P53671
MWKSQYVPYDGIPFV

CARF

261

Q8N187
MINRFIYGKGWDPYV

CPVL

461

Q9H3G5
IMKNFPYYRENKQGW

FOXG1

211

P55316
VTMNISQMITYWGYP

LIPF

31

P07098
IEWYRKKMPFSYPQQ

HS3ST5

136

Q8IZT8
GVIYLKNMITQYWPD

IPO7

56

O95373
QMLYNLWGPDKTISY

OR2W6P

86

Q8NHA6
EGVNTPYLYFGMWKT

KDM4C

171

Q9H3R0
VIEGVNTPYLYFGMW

KDM4D

171

Q6B0I6
YFAWLGVYTQMLIPA

ANO1

331

Q5XXA6
MLPKYGDYYVWNKVT

OSBPL6

716

Q9BZF3
WNVPYMANVYLIKGK

PLOD2

456

O00469
FLGSMKPWNYKYNPQ

GYG2

246

O15488
VIITSYNIWNMDPGY

ATP6AP2

321

O75787
SQIYEWMVSCVPYFK

FOXO3B

266

A0A2Z4LIS9
FQYAIQKKWPLYMST

IDH2

236

P48735
QFSKMGKQLTYTYPW

DNASE2

166

O00115
YYQVKQPRWMETVKV

DOCK2

481

Q92608
MKIQSGAWVCYQYPG

CRYBA1

161

P05813
TLLKMWFPEVQNIYY

DNAH7

326

Q8WXX0
WVQAMYRATGQSYKP

CADPS2

581

Q86UW7
LDGYQIPKGWSVMYS

CYP26C1

396

Q6V0L0
IWGSVMYPYQLQQEL

MS4A4E

86

Q96PG1
IPMKPYYTKVYQEIW

ATP5MJ

11

P56378
GQVEYKPLSGIRYMW

SLC44A3

366

Q8N4M1
NYPNTFWMNPQYLIK

CAPN2

376

P17655
VTLVPYWMVYFQMQS

SLC15A3

321

Q8IY34
YYVMSGPAWQLMQQF

ODC1

406

P11926
GMPTLAVDFIYNYWK

JADE3

421

Q92613
AAIYLKNMVTQYWPD

IPO8

56

O15397
MVAWLGYTPYKVTYA

QARS1

321

P47897
YIGSVEPLTQFMWVY

TOP2B

71

Q02880
MIRAVQPGETYTYKW

F5

471

P12259
ETGMIVWFKYQKYPF

PWWP3B

391

Q5H9M0
NTAVMQRLAPKYYWA

LAMA1

556

P25391
YPVAWVNTMVFDFKG

PIK3CB

436

P42338
SVPATYQIYYMIGWK

NDUFAF5

296

Q5TEU4
QIWPVYVMFQLTYCK

OR9A4

156

Q8NGU2
WVGLYKNGTPVMYTY

COL10A1

611

Q03692
PIQYPDIWKMYKQAQ

RRM2B

46

Q7LG56
GWKPEISQDTMYLQY

ZDHHC6

86

Q9H6R6
PGVYGNVMVFTDWIY

TMPRSS2

471

O15393
YLSGLMYWPFVQLTN

MPV17L

126

Q2QL34
FMQGQVPYGSWYKHV

SULT1E1

161

P49888
PVMNTWFYITYEKDP

SPIN3

156

Q5JUX0
PAFKYYNMWISLLGA

SLC12A2

706

P55011
YLYTYKMPGDIKNWV

EXT2

606

Q93063
GNLVVAMFIKYWIYV

PIEZO2

676

Q9H5I5
FDGIMYYLTPQWDKI

SLC6A9

341

P48067
KPRWVKIFTPYFNYM

SNX27

496

Q96L92
GYVAEQFGWTVYIVM

SPCS1

106

Q9Y6A9
MPLRNIFKNCTYYWG

TECR

156

Q9NZ01
MVVSIGWNPYYKNTK

RFK

61

Q969G6
VNIIFPMYVTGKWNY

VN1R4

141

Q7Z5H5
PMYVTGKWNYTNITV

VN1R4

146

Q7Z5H5
WYKQPSSGEMIFLIY

TRAV14DV4

56

A0A0A6YYC5
MASFYWRIKNEPYQV

TTC17

231

Q96AE7
SQNKMWYPYGIAQVS

nan

101

Q6ZUG5
YYTWPKNMVVYAGVE

PSME4

1276

Q14997
PQAKQWFSMYKPITY

TPGS2

216

Q68CL5
PQPMGVFQKEYWNTY

ZNF75D

166

P51815
VQYYWVDVMLNPGSA

TRIM22

296

Q8IYM9
YGQQIPMEEKRGWYF

TTC22

186

Q5TAA0
MYIWNGYAVIGKQPK

TTC39A

461

Q5SRH9
TMEFWKGYPNAVYSV

PRRG3

56

Q9BZD7
IYWIIGNTSPVTYNM

SLC35E3

241

Q7Z769
PAVYTQICKYMSWIN

KLK10

256

O43240
NPSGVVMWYLYPIKN

NAGA

391

P17050
YQVYFMRKLWLNISP

MYO7B

1886

Q6PIF6
KIVPKNPYYFWSVMS

NAA25

141

Q14CX7