Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidate phosphatase activity	LPIN1 PLPP1 PLPP2 LPIN2	2.07e-06	14	138	4	GO:0008195
GeneOntologyMolecularFunction	arylesterase activity	PON1 CA1 CA2	6.36e-06	6	138	3	GO:0004064
GeneOntologyMolecularFunction	lipid phosphatase activity	LPIN1 PLPP1 PLPP2 LPIN2	7.81e-06	19	138	4	GO:0042577
GeneOntologyMolecularFunction	cyanamide hydratase activity	CA1 CA2	4.74e-05	2	138	2	GO:0018820
GeneOntologyMolecularFunction	ceramide-1-phosphate phosphatase activity	PLPP1 PLPP2	1.42e-04	3	138	2	GO:0106235
GeneOntologyMolecularFunction	phenanthrene-9,10-epoxide hydrolase activity	AKR7L AKR7A3	1.42e-04	3	138	2	GO:0019119
GeneOntologyMolecularFunction	phenanthrene-epoxide hydrolase activity	AKR7L AKR7A3	1.42e-04	3	138	2	GO:0019118
GeneOntologyMolecularFunction	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	PCMTD1 PCMTD2	1.42e-04	3	138	2	GO:0004719
GeneOntologyMolecularFunction	carbonate dehydratase activity	CA1 CA2 CA7	1.69e-04	16	138	3	GO:0004089
GeneOntologyMolecularFunction	protein carboxyl O-methyltransferase activity	PCMTD1 PCMTD2	9.73e-04	7	138	2	GO:0051998
GeneOntologyMolecularFunction	sphingosine-1-phosphate phosphatase activity	PLPP1 PLPP2	9.73e-04	7	138	2	GO:0042392
GeneOntologyMolecularFunction	carboxyl-O-methyltransferase activity	PCMTD1 PCMTD2	9.73e-04	7	138	2	GO:0010340
Domain	Carbonic_anhydrase_a-class_CS	CA1 CA2 CA7	8.27e-05	12	138	3	IPR018338
Domain	Lipin_N	LPIN1 LPIN2	1.62e-04	3	138	2	IPR007651
Domain	Lipin_mid	LPIN1 LPIN2	1.62e-04	3	138	2	IPR031703
Domain	Lipin_N	LPIN1 LPIN2	1.62e-04	3	138	2	PF04571
Domain	VPS13	VPS13C VPS13A	1.62e-04	3	138	2	IPR026847
Domain	PCMT	PCMTD1 PCMTD2	1.62e-04	3	138	2	IPR000682
Domain	VPS13_mid_rpt	VPS13C VPS13A	1.62e-04	3	138	2	PF16910
Domain	VPS13	VPS13C VPS13A	1.62e-04	3	138	2	PF16908
Domain	Lipin_mid	LPIN1 LPIN2	1.62e-04	3	138	2	PF16876
Domain	VPS13_N2	VPS13C VPS13A	1.62e-04	3	138	2	IPR031646
Domain	VPS13_mid_rpt	VPS13C VPS13A	1.62e-04	3	138	2	IPR031642
Domain	PCMT	PCMTD1 PCMTD2	1.62e-04	3	138	2	PS01279
Domain	Carbonic_anhydrase_a-class	CA1 CA2 CA7	1.68e-04	15	138	3	IPR023561
Domain	ALPHA_CA_1	CA1 CA2 CA7	1.68e-04	15	138	3	PS00162
Domain	Carb_anhydrase	CA1 CA2 CA7	2.49e-04	17	138	3	PF00194
Domain	Carb_anhydrase	CA1 CA2 CA7	2.49e-04	17	138	3	SM01057
Domain	-	CA1 CA2 CA7	2.49e-04	17	138	3	3.10.200.10
Domain	ALPHA_CA_2	CA1 CA2 CA7	2.49e-04	17	138	3	PS51144
Domain	Carbonic_anhydrase_a	CA1 CA2 CA7	2.49e-04	17	138	3	IPR001148
Domain	SHR-BD	VPS13C VPS13A	3.22e-04	4	138	2	IPR009543
Domain	VPS13_C	VPS13C VPS13A	3.22e-04	4	138	2	PF16909
Domain	VPS13_C	VPS13C VPS13A	3.22e-04	4	138	2	IPR031645
Domain	SHR-BD	VPS13C VPS13A	3.22e-04	4	138	2	PF06650
Domain	Autophagy-rel_C	VPS13C VPS13A	5.34e-04	5	138	2	IPR015412
Domain	ATG_C	VPS13C VPS13A	5.34e-04	5	138	2	PF09333
Domain	TIF_beta_prop-like	DCAF13 WDHD1	5.34e-04	5	138	2	IPR013979
Domain	eIF2A	DCAF13 WDHD1	5.34e-04	5	138	2	PF08662
Domain	LNS2	LPIN1 LPIN2	7.97e-04	6	138	2	IPR013209
Domain	LNS2	LPIN1 LPIN2	7.97e-04	6	138	2	SM00775
Domain	LNS2	LPIN1 LPIN2	7.97e-04	6	138	2	PF08235
Domain	ENTH	ENTHD1 EPN2	7.97e-04	6	138	2	PF01417
Domain	LNS2/PITP	LPIN1 LPIN2	7.97e-04	6	138	2	IPR031315
Domain	-	ENTHD1 EPN2 PCF11	9.06e-04	26	138	3	1.25.40.90
Domain	ARM-type_fold	TNPO1 VPS11 USP24 PSMD2 ARMC2 PPP2R5C PIK3C2G ULK4 STAG3L3	9.49e-04	339	138	9	IPR016024
Domain	ENTH_VHS	ENTHD1 EPN2 PCF11	1.25e-03	29	138	3	IPR008942
Domain	USP_CS	USP13 USP11 USP24 USP12	1.44e-03	66	138	4	IPR018200
Domain	Chorein_N	VPS13C VPS13A	1.47e-03	8	138	2	PF12624
Domain	VPS13_N	VPS13C VPS13A	1.47e-03	8	138	2	IPR026854
Domain	PH	DOK6 OBSCN PLEKHH1 GRK3 OSBPL6 PLD1 PLEKHH2	1.58e-03	229	138	7	PF00169
Domain	USP_1	USP13 USP11 USP24 USP12	1.79e-03	70	138	4	PS00972
Domain	MYTH4	PLEKHH1 PLEKHH2	1.89e-03	9	138	2	PS51016
Domain	MyTH4	PLEKHH1 PLEKHH2	1.89e-03	9	138	2	SM00139
Domain	ENTH	ENTHD1 EPN2	1.89e-03	9	138	2	PS50942
Domain	MyTH4_dom	PLEKHH1 PLEKHH2	1.89e-03	9	138	2	IPR000857
Domain	MyTH4	PLEKHH1 PLEKHH2	1.89e-03	9	138	2	PF00784
Domain	ENTH	ENTHD1 EPN2	1.89e-03	9	138	2	SM00273
Domain	UCH	USP13 USP11 USP24 USP12	1.89e-03	71	138	4	PF00443
Domain	USP_2	USP13 USP11 USP24 USP12	1.89e-03	71	138	4	PS00973
Domain	USP_3	USP13 USP11 USP24 USP12	1.99e-03	72	138	4	PS50235
Domain	USP_dom	USP13 USP11 USP24 USP12	1.99e-03	72	138	4	IPR028889
Domain	Peptidase_C19_UCH	USP13 USP11 USP24 USP12	1.99e-03	72	138	4	IPR001394
Domain	ENTH	ENTHD1 EPN2	2.35e-03	10	138	2	IPR013809
Pathway	REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE	CA1 CA2 CA7	7.72e-05	12	102	3	M671
Pathway	REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE	CA1 CA2 CA7	7.72e-05	12	102	3	MM14574
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	VPS11 TRIM25 RBBP7 USP11 SMC4 PSMD2 LPIN1 WDHD1 PLPP1 WDR11 DDX28	7.37e-08	313	142	11	38270169
Pubmed	Human carbonic anhydrases and carbonic anhydrase deficiencies.	CA1 CA2 CA7	6.62e-07	5	142	3	7574487
Pubmed	STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.	STAG3L1 STAG3L2 STAG3L3	6.62e-07	5	142	3	10698974
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TNPO1 TRIM25 RBBP7 USP11 ACLY GRAMD1A SMC4 PSMD2 CCT7 CHD1 WDR26 ERLEC1 PTPN14 ACAD11 CDC73	1.15e-05	974	142	15	28675297
Pubmed	A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system.	CA1 CA2 CA7	1.43e-05	12	142	3	17362527
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 DCAF13 RBBP7 USP11 ACLY USP24 SMC4 PSMD2 CHD1 THOC2 GLYR1 RRP7A	1.64e-05	653	142	12	22586326
Pubmed	Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.	CA2 CA7	1.66e-05	2	142	2	23881097
Pubmed	Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.	CA1 CA2	1.66e-05	2	142	2	16686544
Pubmed	A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.	LPIN1 LPIN2	1.66e-05	2	142	2	19717560
Pubmed	High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors.	FAS F8	1.66e-05	2	142	2	16091456
Pubmed	Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.	LPIN1 LPIN2	1.66e-05	2	142	2	24133206
Pubmed	Factor XIII A subunit Val34Leu polymorphism in patients suffering atherothrombotic ischemic stroke.	F8 F13A1	1.66e-05	2	142	2	20609463
Pubmed	Identification of a novel human phosphatidic acid phosphatase type 2 isoform.	PLPP1 PLPP2	1.66e-05	2	142	2	9607309
Pubmed	Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.	LPIN1 LPIN2	1.66e-05	2	142	2	22908270
Pubmed	USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.	HGF USP11	1.66e-05	2	142	2	37973952
Pubmed	Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.	CA1 CA2	1.66e-05	2	142	2	17127057
Pubmed	Down-regulation of Fas-mediated apoptosis by plasma transglutaminase factor XIII that catalyzes fetal-specific cross-link of the Fas molecule.	FAS F13A1	1.66e-05	2	142	2	24216108
Pubmed	Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells.	PLPP1 PLPP2	1.66e-05	2	142	2	9570154
Pubmed	Factor XIII Val34Leu variant protects against coronary artery disease. A meta-analysis.	F8 F13A1	1.66e-05	2	142	2	17334514
Pubmed	Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle.	LPIN1 LPIN2	1.66e-05	2	142	2	31752156
Pubmed	Autoantibodies Against Carbonic Anhydrase I and II in Patients with Acute Myeloid Leukemia.	CA1 CA2	1.66e-05	2	142	2	28270370
Pubmed	Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.	LPIN1 LPIN2	1.66e-05	2	142	2	29534981
Pubmed	Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649).	CA1 CA2	1.66e-05	2	142	2	27475498
Pubmed	Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes.	CA1 CA2	1.66e-05	2	142	2	28445001
Pubmed	Human carbonic anhydrases. XII. The complete primary structure of the C isozyme.	CA1 CA2	1.66e-05	2	142	2	4207120
Pubmed	The Effect of Nanoparticles on the Structure and Enzymatic Activity of Human Carbonic Anhydrase I and II.	CA1 CA2	1.66e-05	2	142	2	32992797
Pubmed	Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.	VPS13C VPS13A	1.66e-05	2	142	2	17196930
Pubmed	The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities.	LPIN1 LPIN2	1.66e-05	2	142	2	2722772
Pubmed	Carbonic anhydrase enzymes regulate mast cell-mediated inflammation.	CA1 CA2	1.66e-05	2	142	2	27526715
Pubmed	Synthesis and in vitro inhibition effect of new pyrido[2,3-d]pyrimidine derivatives on erythrocyte carbonic anhydrase I and II.	CA1 CA2	1.66e-05	2	142	2	25165709
Pubmed	Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray.	CA1 CA2	1.66e-05	2	142	2	22416960
Pubmed	Erythrocyte zinc and carbonic anhydrase levels in nondialyzed chronic kidney disease patients.	CA1 CA2	1.66e-05	2	142	2	14675565
Pubmed	Catalytic and inhibitor-binding properties of some active-site mutants of human carbonic anhydrase I.	CA1 CA2	1.66e-05	2	142	2	7758465
Pubmed	Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.	CA1 CA2	1.66e-05	2	142	2	24670789
Pubmed	Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.	CA1 CA2	1.66e-05	2	142	2	16807956
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	RBBP7 USP11 ACLY SMC4 PSMD2 CCT7 WDR26 ACAD11 GLYR1 CDC73 CA2	1.76e-05	551	142	11	34728620
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	UNC13B USP11 VPS13C TBC1D17 ACAD11 WDR11 VPS13A	2.56e-05	209	142	7	26389662
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MYO5B GRAMD1A PSMD2 CCT7 PCF11 PPP2R5C PTPN14 YEATS4 WDR11 PRPF3 GLYR1 SORBS3 VPS13A USP12 TRIM36	2.72e-05	1049	142	15	27880917
Pubmed	Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.	TRIM25 RBBP7 ACLY SMC4 WDHD1	2.98e-05	87	142	5	24169447
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	SMC4 ZBTB47 PSMD2 PCMTD1 YEATS4 PRPF3 PCMTD2 CDC73 DDX28	3.87e-05	396	142	9	26687479
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	TRIM25 SMC4 PSMD2 CCT7 RGS11 FXN PTPN14 ACAD11 WDHD1 WDR11 PRPF3 CDC73 MRPL46 MASP2	4.68e-05	971	142	14	33306668
Pubmed	Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.	LPIN1 LPIN2	4.95e-05	3	142	2	10884287
Pubmed	Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse.	CA1 CA2	4.95e-05	3	142	2	825106
Pubmed	VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.	VPS13C VPS13A	4.95e-05	3	142	2	30093493
Pubmed	[Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].	AKR7L AKR7A3	4.95e-05	3	142	2	22863590
Pubmed	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.	LPIN1 LPIN2	4.95e-05	3	142	2	18694939
Pubmed	Amplification of USP13 drives ovarian cancer metabolism.	USP13 ACLY	4.95e-05	3	142	2	27892457
Pubmed	Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.	PLPP1 PLPP2	4.95e-05	3	142	2	9705349
Pubmed	Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase.	PLPP1 PLPP2	4.95e-05	3	142	2	12471011
Pubmed	Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.	LPIN1 LPIN2	4.95e-05	3	142	2	33596934
Pubmed	Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases.	CA1 CA2	4.95e-05	3	142	2	12930737
Pubmed	Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8.	CA1 CA2	4.95e-05	3	142	2	2111277
Pubmed	Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.	AKR7L AKR7A3	4.95e-05	3	142	2	12123834
Pubmed	Selected apoptotic markers in serum of patients with chronic viral hepatitis C.	HGF FAS	4.95e-05	3	142	2	25338331
Pubmed	Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.	CA1 CA2	4.95e-05	3	142	2	15837325
Pubmed	Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.	AKR7L AKR7A3	4.95e-05	3	142	2	24590062
Pubmed	Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis.	LPIN1 LPIN2	4.95e-05	3	142	2	30507612
Pubmed	Lipin proteins form homo- and hetero-oligomers.	LPIN1 LPIN2	4.95e-05	3	142	2	20735359
Pubmed	Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.	AKR7L AKR7A3	4.95e-05	3	142	2	12071861
Pubmed	Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.	LPIN1 LPIN2	4.95e-05	3	142	2	22481384
Pubmed	Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.	PLPP1 PLPP2	4.95e-05	3	142	2	18215144
Pubmed	Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.	AKR7L AKR7A3	4.95e-05	3	142	2	16919859
Pubmed	Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa.	CA1 CA2	4.95e-05	3	142	2	15836783
Pubmed	Dietary cholesterol reduces plasma triacylglycerol in apolipoprotein E-null mice: suppression of lipin-1 and -2 in the glycerol-3-phosphate pathway.	LPIN1 LPIN2	4.95e-05	3	142	2	21857965
Pubmed	Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8.	CA1 CA2	4.95e-05	3	142	2	1916821
Pubmed	Lipin-1 and lipin-3 together determine adiposity in vivo.	LPIN1 LPIN2	4.95e-05	3	142	2	24634820
Pubmed	Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.	CA1 CA2	4.95e-05	3	142	2	19206230
Pubmed	EGF and HGF levels are increased during active HBV infection and enhance survival signaling through extracellular matrix interactions in primary human hepatocytes.	HGF FAS	4.95e-05	3	142	2	18844210
Pubmed	TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.	VPS13C VPS13A	4.95e-05	3	142	2	33087848
Pubmed	AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.	AKR7L AKR7A3	4.95e-05	3	142	2	39365156
Pubmed	Genes on chromosome 3 of the mouse.	CA1 CA2	4.95e-05	3	142	2	820740
Pubmed	Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.	LPIN1 LPIN2	4.95e-05	3	142	2	17158099
Pubmed	Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke.	F8 F13A1	4.95e-05	3	142	2	17927806
Pubmed	Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex.	CHD1 CDC73	4.95e-05	3	142	2	34424918
Pubmed	Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes.	CA1 CA2	4.95e-05	3	142	2	28613396
Pubmed	Vascular cell adhesion molecule 1, soluble Fas and hepatocyte growth factor as predictors of mortality in nonagenarians: the Vitality 90+ study.	HGF FAS	4.95e-05	3	142	2	23911532
Pubmed	Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association.	LPIN1 PLPP1	4.95e-05	3	142	2	23426360
Pubmed	Unlocking the Potential of the CA2, CA7, and ITM2C Gene Signatures for the Early Detection of Colorectal Cancer: A Comprehensive Analysis of RNA-Seq Data by Utilizing Machine Learning Algorithms.	CA2 CA7	4.95e-05	3	142	2	37895185
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	VPS13C CYP27A1 SMC4 PSMD2 CCT7 FAS MOB2 YEATS4 PRPF3 GLYR1 ULK4 PLEKHH2	6.60e-05	754	142	12	35906200
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TNPO1 USP13 TRIM25 RBBP7 USP11 SMC4 CCT7 CHD1 THOC2 WDR26 WDHD1 PRPF3 CDC73 MBD4	7.42e-05	1014	142	14	32416067
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	TNPO1 ACLY SMC4 PSMD2 RGS11 FAS WDHD1 WDR11 PRPF3 CDC73 MASP2	8.14e-05	653	142	11	33742100
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	RBBP7 USP11 GRAMD1A CHD1 WDR26 GLYR1 RRP7A	8.57e-05	253	142	7	29911972
Pubmed	A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.	CA1 CA2 CA7	9.69e-05	22	142	3	23233153
Pubmed	Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.	AKR7L AKR7A3	9.88e-05	4	142	2	12879023
Pubmed	Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.	LPIN1 LPIN2	9.88e-05	4	142	2	19136718
Pubmed	Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas.	CA2 CA7	9.88e-05	4	142	2	27688658
Pubmed	Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.	CA1 CA2	9.88e-05	4	142	2	24878360
Pubmed	Lack of association between FXIII-Val34Leu, FVII-323 del/ins, and transforming growth factor beta1 (915G/T) gene polymorphisms and bronchopulmonary dysplasia: a single-center study.	F8 F13A1	9.88e-05	4	142	2	19778283
Pubmed	Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin.	LPIN1 LPIN2	9.88e-05	4	142	2	11138012
Pubmed	Analysis of the human VPS13 gene family.	VPS13C VPS13A	9.88e-05	4	142	2	15498460
Pubmed	Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base.	CA1 CA2	9.88e-05	4	142	2	28544359
Pubmed	Factor XIII activity mediates red blood cell retention in venous thrombi.	F8 F13A1	9.88e-05	4	142	2	24983320
Pubmed	Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.	USP13 PSMD2	9.88e-05	4	142	2	21571647
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	TNPO1 EFCAB5 TRIM25 RBBP7 ACLY SMC4 PSMD2 CCT7 THOC2 WDR26 WDR11 MRPL46	1.28e-04	809	142	12	32129710
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	DCAF13 RBBP7 ACLY SMC4 SHC4 PSMD2 CCT7 THOC2 PRPF3 GLYR1 TAX1BP1 RRP7A DDX28	1.46e-04	949	142	13	36574265
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 TNPO1 OGFRL1 OBSCN ZNF267 ZBTB41 ZDHHC17 THOC2 F13A1 PPP2R5C WDHD1 GLYR1 PLD1 FHIP2B	1.49e-04	1084	142	14	11544199
Pubmed	Mutation of FAS, XIAP, and UNC13D genes in a patient with a complex lymphoproliferative phenotype.	UNC13B FAS	1.64e-04	5	142	2	24043286
Pubmed	A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans.	ZP1 CD9	1.64e-04	5	142	2	24934154
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP13 USP11 USP24 PSMD2 PCMTD1 EPN2 TAX1BP1 RNF216 PCMTD2	1.69e-04	481	142	9	28190767
Pubmed	Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.	ACLY PSMD2 WDR26	1.81e-04	27	142	3	21320693
GeneFamily	Lipins	LPIN1 LPIN2	9.24e-05	3	101	2	1043
GeneFamily	Carbonic anhydrases	CA1 CA2 CA7	1.30e-04	18	101	3	460
GeneFamily	Ubiquitin specific peptidases	USP13 USP11 USP24 USP12	2.70e-04	56	101	4	366
GeneFamily	Phospholipid phosphatases	PLPP1 PLPP2	6.37e-04	7	101	2	1067
GeneFamily	Fibronectin type III domain containing	OBSCN FANK1 MYOM2 TRIM36 USH2A	2.04e-03	160	101	5	555
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF267 ZBTB47 ZNF233 ZBTB41 PRDM4 ZXDB ZNF766 ZNF721 ZNF664 ZNF653 ZNF286A	2.22e-03	718	101	11	28
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PLEKHH1 PTPN14 PLEKHH2	2.74e-03	50	101	3	1293
Coexpression	GSE22589_HEALTHY_VS_SIV_INFECTED_DC_DN	FSTL5 SHC4 DRAM2 PLEKHH1 TAX1BP1 UGGT2 CD180 ENOX2	1.35e-05	199	142	8	M7809
Coexpression	GSE16385_IFNG_TNF_VS_UNSTIM_MACROPHAGE_ROSIGLITAZONE_TREATED_DN	ASTE1 WDR26 ATP8A1 PRPF3 TAX1BP1 PCMTD2 MYOM2 MBD4	1.40e-05	200	142	8	M8032
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN GRIK3 NEB PKHD1L1 PIK3C2G NAV3 MYOM2 USH2A	1.41e-07	184	142	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN GRIK3 NEB PKHD1L1 PIK3C2G NAV3 MYOM2 USH2A	1.41e-07	184	142	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN GRIK3 NEB PKHD1L1 PIK3C2G NAV3 MYOM2 USH2A	1.41e-07	184	142	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPM6 CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	2.29e-06	186	142	7	d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGF USP13 PKHD1L1 PTPN14 PLPP1 PIK3C2G FGR	2.29e-06	186	142	7	9579180db2a0bf3f043b4d169f9a08cdc45b459a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS35 PON1 AKR7A3 NAV3 MMP16 ZNF286A	8.75e-06	150	142	6	909ccab92855f5f049dc29593aadab1ea973297b
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF233 MYOM2 PLD1 TRIM36 TINCR CA7	1.06e-05	155	142	6	5fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	FSTL5 OBSCN SHC4 NEB ULK4 MYOM2	1.61e-05	167	142	6	e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCell	COVID-19-lung-RBC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PKHD1L1 F13A1 TFR2 CA1 CA2 PEAR1	2.10e-05	175	142	6	4c35292ad2ac712ba7516f27dd6eac6ba8fdd163
ToppCell	5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGF USP13 PKHD1L1 F8 PLPP1 PIK3C2G	2.38e-05	179	142	6	40c65e8623547aeb80f9cd2366e29072467ce069
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PKHD1L1 F8 PTPN14 PIK3C2G FGR MMP16	2.38e-05	179	142	6	ec1d7017da325647b629de703135a404bbdc627d
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKHD1L1 F8 PTPN14 NAV3 MMP16 PEAR1	2.70e-05	183	142	6	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	2.78e-05	184	142	6	5939527d24d299e562e707469c9123890edd76be
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	2.78e-05	184	142	6	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMC4 CHD1 FAS F13A1 BTG1 PCMTD2	2.87e-05	185	142	6	7acc071ea75442817db4d98bd3ed3fff6f0a9d46
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKHD1L1 F8 PTPN14 NAV3 MMP16 PEAR1	2.96e-05	186	142	6	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	3.14e-05	188	142	6	14072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	3.14e-05	188	142	6	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	3.14e-05	188	142	6	b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PKHD1L1 F8 PTPN14 PLPP1 PLD1 PEAR1	3.14e-05	188	142	6	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	3.23e-05	189	142	6	70eea8c94fa56bb15bee8065de47acea156794e9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	3.23e-05	189	142	6	b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH3 ARMC2 FANK1 EFHC1 TMEM232 ULK4	3.23e-05	189	142	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 PLD1 CA2	3.33e-05	190	142	6	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	UNC13B MYO5B FSTL5 ATP8A1 CD9 PLPP2	3.64e-05	193	142	6	aa10924b203c71e65fdbd2b90ba131dbd362d8b1
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH3 ARMC2 FANK1 EFHC1 TMEM232 ULK4	3.64e-05	193	142	6	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH3 ARMC2 FANK1 EFHC1 TMEM232 ULK4	3.64e-05	193	142	6	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP13 PKHD1L1 F8 PTPN14 CD9 PLPP1	3.85e-05	195	142	6	590c0dc0db4dc62879645ed7f61292ff97d2c7d5
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH3 ARMC2 FANK1 EFHC1 TMEM232 OSBPL6	4.08e-05	197	142	6	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRDM4 F8 ZXDB PTPN14 PCMTD2 DDX28	4.08e-05	197	142	6	789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP13 PKHD1L1 F8 PTPN14 PLPP1 PEAR1	4.08e-05	197	142	6	407231542fa1ffd540dcb61435c0575e71f59725
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OGFRL1 GRAMD1A DRAM2 BTG1 USP12 FGR	4.19e-05	198	142	6	455d55cfdeb8b6b13c289b53e1a5184a574e2e35
ToppCell	Biopsy_Control_(H.)-Epithelial-Ciliated\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	DNAH3 FANK1 EFHC1 TMEM232 PLPP2 OSBPL6	4.43e-05	200	142	6	9ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOK6 PKHD1L1 F8 F13A1 CD9 VPS13A	4.43e-05	200	142	6	326cae37cacd94b423a6ac8873ea56c5abaf0a0b
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRSS35 DNAH3 ALS2CL USP12 DDX28	7.80e-05	137	142	5	8e2fa2ef8becace96a68bb85c002329110902fbb
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZBTB47 ALS2CL F8 ABCD2 MASP2	9.55e-05	143	142	5	57ee1830d96d73d92b5f83b028592a5d952c6013
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCP11 F13A1 ZP1 ATP8A1 GRK3	1.16e-04	149	142	5	48fca6ae33d7722c024b43ce04f4dbce7b6b424b
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCP11 F13A1 ZP1 ATP8A1 GRK3	1.27e-04	152	142	5	7e686721b95c837f2b0d5116927c8ecacef055ee
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B EFCAB5 NAV3 PLEKHH2 MASP2	1.52e-04	158	142	5	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B EFCAB5 NAV3 PLEKHH2 MASP2	1.52e-04	158	142	5	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-6\|TCGA-Colorectal / Sample_Type by Project: Shred V9	TRPM6 TINCR CA1 CA2 CA7	1.71e-04	162	142	5	7f9385aa749bfb2fa9fee6939fe46d946bc21d31
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	EFCAB5 OBSCN GRIK3 TMEM232 CA7	1.76e-04	163	142	5	218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell	356C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EPN2 PLPP2 PITPNA PLD1 ZNF664	1.76e-04	163	142	5	2dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PKHD1L1 F13A1 CD9 CA2 PEAR1	1.87e-04	165	142	5	6799a6580c667738995cceb31cbf1c7fbdc4ff84
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PKHD1L1 F13A1 CD9 CA2 PEAR1	1.87e-04	165	142	5	8329d780f244bc31344443b29e5a00529a016662
ToppCell	droplet-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F13A1 GRK3 NAV3 FGR ABCD2	1.92e-04	166	142	5	e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCell	droplet-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F13A1 GRK3 NAV3 FGR ABCD2	1.92e-04	166	142	5	3ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCell	droplet-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F13A1 GRK3 NAV3 FGR ABCD2	1.92e-04	166	142	5	f751cbd01d4978ded7755874ab60504f6291afd7
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	PRSS35 WDHD1 OSBPL6 NAV3 SH3RF3	1.97e-04	167	142	5	9062577a4b7902c9a888d706589d1b05221c0fa8
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN PKHD1L1 F8 PTPN14 PEAR1	1.97e-04	167	142	5	a4a795751644b22af616335379e64ae95175180c
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ASTE1 RNF216 PCMTD2 PLEKHH2 PEAR1	2.03e-04	168	142	5	c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OGFRL1 CYP27A1 F13A1 GRK3 FGR	2.03e-04	168	142	5	f3b7a7df54988de77dcc7066e2fc1feb9c280b13
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ASTE1 RNF216 PCMTD2 PLEKHH2 PEAR1	2.03e-04	168	142	5	83b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 EFHC1 TMEM232 OSBPL6 ULK4	2.09e-04	169	142	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A RGS11 ALS2CL CD9 BTG1	2.14e-04	170	142	5	90f7640f04672c800cb28aea50004b1bb0565e8a
ToppCell	COVID-19-lung-RBC\|lung / Disease (COVID-19 only), tissue and cell type	PKHD1L1 TFR2 CA1 CA2 PEAR1	2.20e-04	171	142	5	0e8d63c8fbccdda4f1ef00de00667a50464b104b
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN4\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A RGS11 ALS2CL CD9 BTG1	2.20e-04	171	142	5	f08402d0f42822c35673522043b652f8fb68d2f6
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 USP24 ATP8A1 PIK3C2G CA2	2.32e-04	173	142	5	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH3 ARMC2 EFHC1 TMEM232 OSBPL6	2.32e-04	173	142	5	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	TNPO1 EFCAB5 ZDHHC17 FBXL3 ZNF664	2.32e-04	173	142	5	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PKHD1L1 F8 PLPP1 PIK3C2G PEAR1	2.52e-04	176	142	5	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	DOK6 TRIM25 MAN2A1 LPIN1 TMEM168	2.52e-04	176	142	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ASTE1 GRK3 LACC1 TMEM39A ZNF653	2.58e-04	177	142	5	f360f7099570d248531897b96e0de282e58f59e9
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	DOK6 TRIM25 MAN2A1 LPIN1 TMEM168	2.58e-04	177	142	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PKHD1L1 F8 PTPN14 NAV3 PEAR1	2.65e-04	178	142	5	ad3de3e03a401dac64431a541899445262246347
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TMEM168 VPS13A TMEM39A PLD1 DHTKD1	2.72e-04	179	142	5	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP13 F8 CD9 PLPP1 SH3RF3	2.79e-04	180	142	5	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	RA-16._Neuronal\|World / Chamber and Cluster_Paper	OGFRL1 SHC4 GRIK3 CD9 SH3RF3	2.86e-04	181	142	5	7d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOK6 SHC4 RGS11 GRIK3 TMEM232	2.86e-04	181	142	5	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOK6 SHC4 RGS11 GRIK3 TMEM232	2.86e-04	181	142	5	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal\|TCGA-Colorectal / Sample_Type by Project: Shred V9	TRPM6 GRIK3 PKHD1L1 CA1 CA7	2.86e-04	181	142	5	88f6f56f5f58b479d5db91b32c45934c045f88ea
ToppCell	5'-Adult-Appendix-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOK6 SHC4 RGS11 GRIK3 TMEM232	2.86e-04	181	142	5	e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGF PKHD1L1 PLPP1 PIK3C2G MMP16	2.94e-04	182	142	5	82d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCell	3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|bone_marrow / Manually curated celltypes from each tissue	F13A1 CD9 AKR7A3 CA2 PEAR1	2.94e-04	182	142	5	1a755ea44daf8447a3a1c30de7fdb9c3888bcbde
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.01e-04	183	142	5	5472cdce6d99314d229418412acf1fff6340db7d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.01e-04	183	142	5	93213124e55d1b673dd345188caf8b5bd31d99fe
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5B PKHD1L1 F8 PTPN14 TRIM36	3.01e-04	183	142	5	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRPM6 PLEKHH1 PTPN14 SORBS3 CA7	3.01e-04	183	142	5	351d575339038bd4a66f408da518c567444208e8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.09e-04	184	142	5	f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCell	control-Others\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PKHD1L1 F13A1 CD9 CA2 PEAR1	3.09e-04	184	142	5	a63b39fcc570b554cf10e8e47c2c1e079034768f
ToppCell	control-Others-Megakaryocytes\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PKHD1L1 F13A1 CD9 CA2 PEAR1	3.09e-04	184	142	5	213915f2889ce8ecbe5f7b19bc2b24ed8c5efe1d
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM25 LPIN1 CD9 ABCD2 FHIP2B	3.16e-04	185	142	5	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM25 LPIN1 CD9 ABCD2 FHIP2B	3.16e-04	185	142	5	775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	PKHD1L1 F8 PTPN14 MMP16 PEAR1	3.16e-04	185	142	5	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO5B ASTE1 PKHD1L1 F8 ATP8A1	3.16e-04	185	142	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	Ciliated_cells-B-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH3 FANK1 EFHC1 TMEM232 OSBPL6	3.16e-04	185	142	5	f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	PKHD1L1 F8 PTPN14 MMP16 PEAR1	3.16e-04	185	142	5	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.16e-04	185	142	5	1d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.16e-04	185	142	5	b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DOK6 HGF OBSCN RGS11 PEAR1	3.24e-04	186	142	5	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.24e-04	186	142	5	90eaf6ffb4ce0c34fa1e79f0c8f36f217f44973b
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OGFRL1 PTPN14 CD9 PLPP1 MMP16	3.24e-04	186	142	5	153c8b2fd8a6e2141ca97c626f82e5f081f3180a
ToppCell	Anterior_Cingulate_gyrus_(CgG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FSTL5 STAG3L1 STAG3L2 STAG3L3 TRIM36	3.24e-04	186	142	5	32af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell	severe-Others\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PKHD1L1 F13A1 CD9 CA2 PEAR1	3.24e-04	186	142	5	234a4bc7c3529daf8804f2a366887d02a47075cd
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.24e-04	186	142	5	bd8a9753df219084e19e7f94447856e86608325c
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PLEKHH1 CD9 PLPP2 PLD1 CA2	3.32e-04	187	142	5	f0de86ef25e344d9b1860ee26308877d6c25ed31
ToppCell	severe-Others-Megakaryocytes\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PKHD1L1 F13A1 CD9 CA2 PEAR1	3.32e-04	187	142	5	ef16331d1e5abe6bde7f09793c4a87a6ac24e592
ToppCell	Multiple_Sclerosis-Other\|Multiple_Sclerosis / Disease, Lineage and Cell Type	F13A1 CD9 CA1 CA2 PEAR1	3.32e-04	187	142	5	ca6f53e841fd016804e6e8ccf0199877b0e5cbdd
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 PLEKHH1 CD9 PLPP2 CA2	3.32e-04	187	142	5	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CHD1 PPP2R5C BTG1 FBXO32 ABCD2	3.32e-04	187	142	5	e61c1755531469dd3850c9740474b5ad4e0499c1
Drug	Tyloxapol [25301-02-4]; Down 200; 4uM; MCF7; HT_HG-U133A	OGFRL1 TRIM25 SMC4 FAS ALS2CL EPN2 GRK3 PLPP2 GLYR1	4.20e-06	197	142	9	5672_DN
Drug	diethylmalonic acid	ACLY PLPP1 PLPP2	4.69e-06	6	142	3	CID000068185
Drug	EMD 486019	CA1 CA2 CA7	4.69e-06	6	142	3	CID011245700
Drug	orthanilamide	CA1 CA2 CA7	4.69e-06	6	142	3	CID000072894
Drug	2h15	CA1 CA2 CA7	4.69e-06	6	142	3	CID010712038
Drug	Sulfhydryl Compounds	PON1 CA1 CA2	8.16e-06	7	142	3	ctd:D013438
Drug	aminozolamide	CA1 CA2 CA7	1.30e-05	8	142	3	CID000093505
Drug	L-662,583	CA1 CA2 CA7	1.30e-05	8	142	3	CID003082977
Drug	L-643,799	CA1 CA2 CA7	1.30e-05	8	142	3	CID000121595
Drug	sezolamide	CA1 CA2 CA7	1.30e-05	8	142	3	CID000060692
Drug	potassium cyanate	TRIM25 CA1 CA2 CA7	1.40e-05	24	142	4	CID011378442
Drug	qassa	CA1 CA2 CA7	1.94e-05	9	142	3	CID003082191
Drug	6-hydroxyethoxzolamide	CA1 CA2 CA7	1.94e-05	9	142	3	CID000094706
Drug	Prontosil	CA1 CA2 CA7	2.76e-05	10	142	3	CID000066895
Drug	6,7-dihydro-5H-dibenz(c,e)azepine	ACLY PLPP1 PLPP2	2.76e-05	10	142	3	CID000081183
Drug	metanilamide	CA1 CA2 CA7	2.76e-05	10	142	3	CID000007377
Drug	1,3-benzenedisulfonamide	CA1 CA2 CA7	2.76e-05	10	142	3	CID003090044
Drug	1-methylcyclopentanecarboxylic acid	PSMD2 CHD1 MMP16 CA1 CA2 CA7	2.92e-05	95	142	6	CID000138436
Drug	Fenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A	OGFRL1 DNAH3 DCAF13 ZDHHC17 EPN2 GRK3 SORBS3 MMP16	3.16e-05	195	142	8	7432_DN
Drug	choline	LCT FAS PLPP1 PLPP2 PITPNA VPS13A PLD1 CA1 CA2 CA7	3.38e-05	320	142	10	CID000000305
Drug	Niridazole [61-57-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	NEB ALS2CL TBC1D17 EPN2 PTPN14 GRK3 GLYR1 SORBS3	3.40e-05	197	142	8	5682_DN
Drug	tauroursocholate	CYP27A1 LCT AKR7L PIK3C2G CA1 CA2 CA7	3.73e-05	146	142	7	CID000005246
Drug	Cl 13850	CA1 CA2 CA7	3.78e-05	11	142	3	CID000159459
Drug	STX64	CA1 CA2 CA7	3.78e-05	11	142	3	CID005287541
Drug	cobalt phosphate	CA1 CA2 CA7	3.78e-05	11	142	3	CID000061615
Drug	Tio-urasin	CA1 CA2 CA7	3.78e-05	11	142	3	CID000084724
Drug	AC1LKFXM	CA1 CA2	3.86e-05	2	142	2	CID000990581
Drug	AC1MDL7D	CA1 CA2	3.86e-05	2	142	2	CID002812911
Drug	Glycoconjugate Benzene Sulfonamide 2f	CA1 CA2	3.86e-05	2	142	2	CID011974631
Drug	CHEBI:492478	CA1 CA2	3.86e-05	2	142	2	CID011974633
Drug	Glycoconjugate Benzene Sulfonamide 2d	CA1 CA2	3.86e-05	2	142	2	CID011974630
Drug	hydrazide deriv. 16	CA1 CA2	3.86e-05	2	142	2	CID011287480
Drug	NSC-58318	CA1 CA2	3.86e-05	2	142	2	CID000245904
Drug	Glycoconjugate Benzene Sulfonamide 3g	CA1 CA2	3.86e-05	2	142	2	CID011974559
Drug	Glycoconjugate Benzene Sulfonamide 3e	CA1 CA2	3.86e-05	2	142	2	CID011974558
Drug	Glycoconjugate Benzene Sulfonamide 3ff	CA1 CA2	3.86e-05	2	142	2	CID011974562
Drug	Glycoconjugate Benzene Sulfonamide 3dd	CA1 CA2	3.86e-05	2	142	2	CID011974561
Drug	Glycoconjugate Benzene Sulfonamide 3bb	CA1 CA2	3.86e-05	2	142	2	CID011974560
Drug	urea analog 3a	CA1 CA2	3.86e-05	2	142	2	CID011177131
Drug	Glycoconjugate Benzene Sulfonamide 3d	CA1 CA2	3.86e-05	2	142	2	CID011974456
Drug	Glycoconjugate Benzene Sulfonamide 3b	CA1 CA2	3.86e-05	2	142	2	CID011974455
Drug	Glycoconjugate Benzene Sulfonamide 2dd	CA1 CA2	3.86e-05	2	142	2	CID011974452
Drug	Glycoconjugate Benzene Sulfonamide 2bb	CA1 CA2	3.86e-05	2	142	2	CID011974451
Drug	Glycoconjugate Benzene Sulfonamide 2gg	CA1 CA2	3.86e-05	2	142	2	CID011974454
Drug	Glycoconjugate Benzene Sulfonamide 2ff	CA1 CA2	3.86e-05	2	142	2	CID011974453
Drug	Glycoconjugate Benzene Sulfonamide 3ee	CA1 CA2	3.86e-05	2	142	2	CID011974830
Drug	Glycoconjugate Benzene Sulfonamide 3gg	CA1 CA2	3.86e-05	2	142	2	CID011974831
Drug	DIBA-1	CA1 CA2	3.86e-05	2	142	2	CID000375084
Drug	M2-9	CA1 CA2	3.86e-05	2	142	2	CID016122582
Drug	Glycoconjugate Benzene Sulfonamide 2ee	CA1 CA2	3.86e-05	2	142	2	CID011974727
Drug	CHEBI:492482	CA1 CA2	3.86e-05	2	142	2	CID011974729
Drug	Glycoconjugate Benzene Sulfonamide 3f	CA1 CA2	3.86e-05	2	142	2	CID011974724
Drug	CHEBI:492477	CA1 CA2	3.86e-05	2	142	2	CID011974726
Drug	azide 1	CA1 CA2	3.86e-05	2	142	2	CID003558590
Drug	sulfonyl urea 4e	CA1 CA2	3.86e-05	2	142	2	CID011396353
Drug	silychristin	CA1 CA2	3.86e-05	2	142	2	ctd:C015504
Drug	DNC006490	CA1 CA2	3.86e-05	2	142	2	CID011718391
Drug	AC1MH2M3	CA1 CA2	3.86e-05	2	142	2	CID002970501
Drug	urea analog 3c	CA1 CA2	3.86e-05	2	142	2	CID011235150
Drug	DNC006486	CA1 CA2	3.86e-05	2	142	2	CID011660633
Drug	AC1LQL9N	CA1 CA2	3.86e-05	2	142	2	CID001378039
Drug	T6379926	CA1 CA2	3.86e-05	2	142	2	CID008190912
Drug	N-(4-sulfamoylphenyl)propanamide	CA1 CA2	3.86e-05	2	142	2	CID000847760
Drug	NSC-241624	CA1 CA2	3.86e-05	2	142	2	CID000315810
Drug	DNC006494	CA1 CA2	3.86e-05	2	142	2	CID011659798
Drug	T6377026	CA1 CA2	3.86e-05	2	142	2	CID004572067
Drug	DNC006491	CA1 CA2	3.86e-05	2	142	2	CID011623958
Drug	Glycoconjugate Benzene Sulfonamide 2e	CA1 CA2	3.86e-05	2	142	2	CID011851425
Drug	N-propynyl amide derivative 2	CA1 CA2	3.86e-05	2	142	2	CID011851424
Drug	AC1N6D4T	CA1 CA2	3.86e-05	2	142	2	CID004258082
Drug	Zinc00030344	CA1 CA2	3.86e-05	2	142	2	CID000669716
Drug	CTK6A0685	CA1 CA2	3.86e-05	2	142	2	CID011414131
Drug	lysine cephalexin	CA1 CA2	3.86e-05	2	142	2	CID000042546
Drug	sulfonyl urea 7a	CA1 CA2	3.86e-05	2	142	2	CID011188711
Drug	urea analog 3b	CA1 CA2	3.86e-05	2	142	2	CID011463026
Drug	urea analog 3j	CA1 CA2	3.86e-05	2	142	2	CID011441601
Drug	AC1Q55C7	CA1 CA2	3.86e-05	2	142	2	CID000917163
Drug	DNC006488	CA1 CA2	3.86e-05	2	142	2	CID011536481
Drug	CHEMBL206295	CA1 CA2	3.86e-05	2	142	2	CID011632228
Drug	N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE	CA1 CA2	3.86e-05	2	142	2	DB08155
Drug	3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID	CA1 CA2	3.86e-05	2	142	2	DB08156
Drug	ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE	CA1 CA2	3.86e-05	2	142	2	DB08157
Drug	CHEMBL204326	CA1 CA2	3.86e-05	2	142	2	CID011573504
Drug	urea analog 3g	CA1 CA2	3.86e-05	2	142	2	CID011247335
Drug	CCG-916	CA1 CA2	3.86e-05	2	142	2	CID002725651
Drug	urea analog 3i	CA1 CA2	3.86e-05	2	142	2	CID011317320
Drug	urea analog 3e	CA1 CA2	3.86e-05	2	142	2	CID011223689
Drug	urea analog 3d	CA1 CA2	3.86e-05	2	142	2	CID011164855
Drug	sulfonyl urea 4c	CA1 CA2	3.86e-05	2	142	2	CID011258440
Drug	CTK6A1002	CA1 CA2	3.86e-05	2	142	2	CID011680415
Drug	sulfonyl urea 7d	CA1 CA2	3.86e-05	2	142	2	CID011304583
Drug	AC1MM1G7	CA1 CA2	3.86e-05	2	142	2	CID003253857
Drug	disulfide-containing sulfonamide 4	CA1 CA2	3.86e-05	2	142	2	CID016082755
Drug	disulfide-containing sulfonamide 2b	CA1 CA2	3.86e-05	2	142	2	CID016082756
Drug	disulfide-containing sulfonamide 2d	CA1 CA2	3.86e-05	2	142	2	CID016082757
Drug	disulfide-containing sulfonamide 2a	CA1 CA2	3.86e-05	2	142	2	CID016082752
Drug	disulfide-containing sulfonamide 2c	CA1 CA2	3.86e-05	2	142	2	CID016082753
Drug	disulfide-containing sulfonamide 3	CA1 CA2	3.86e-05	2	142	2	CID016082754
Drug	sulfonyl urea 4d	CA1 CA2	3.86e-05	2	142	2	CID011339017
Drug	DNC006493	CA1 CA2	3.86e-05	2	142	2	CID011640067
Disease	Parkinson's disease 23 (implicated_via_orthology)	VPS13C VPS13A	2.02e-05	2	133	2	DOID:0060896 (implicated_via_orthology)
Disease	choreaacanthocytosis (implicated_via_orthology)	VPS13C VPS13A	2.02e-05	2	133	2	DOID:0050766 (implicated_via_orthology)
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13C VPS13A	6.03e-05	3	133	2	DOID:0111611 (implicated_via_orthology)
Disease	myoglobinuria (implicated_via_orthology)	LPIN1 LPIN2	6.03e-05	3	133	2	DOID:0080108 (implicated_via_orthology)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13A	6.03e-05	3	133	2	DOID:0111590 (implicated_via_orthology)
Disease	alpha-tocopherol measurement	HGF MRPL46 USH2A	9.65e-05	20	133	3	EFO_0007898
Disease	Colorectal Carcinoma	UNC13B DNAH3 FSTL5 OBSCN CHD1 GRIK3 CAPN10 LPIN1 CD9 VPS13A ABCD2	3.50e-04	702	133	11	C0009402
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C VPS13A	5.55e-04	8	133	2	DOID:0050753 (implicated_via_orthology)
Disease	cataract (is_marker_for)	PON1 FAS	7.11e-04	9	133	2	DOID:83 (is_marker_for)
Disease	cysteine measurement	GRIK3 NAV3	7.11e-04	9	133	2	EFO_0021000
Disease	Thrombophilia	F8 F13A1	7.11e-04	9	133	2	C0398623
Disease	complement factor H-related protein 3 measurement	DOK6 ZBTB41 PPP2R5C USH2A SH3RF3	1.03e-03	169	133	5	EFO_0600056
Disease	cognitive impairment measurement	UNC13B NAV3 SH3RF3	1.04e-03	44	133	3	EFO_0007998
Disease	acute myeloid leukemia (is_marker_for)	FAS TFR2 BTG1	1.42e-03	49	133	3	DOID:9119 (is_marker_for)
Disease	Cholestasis	MYO5B CYP27A1 PON1 ERLEC1	1.57e-03	110	133	4	C0008370
Disease	diabetic retinopathy (is_marker_for)	HGF PON1 F13A1	1.88e-03	54	133	3	DOID:8947 (is_marker_for)
Disease	lipid metabolism disorder (implicated_via_orthology)	LPIN1 LPIN2	2.04e-03	15	133	2	DOID:3146 (implicated_via_orthology)
Disease	dermatomyositis (is_marker_for)	HGF FAS	2.62e-03	17	133	2	DOID:10223 (is_marker_for)
Disease	coagulation factor measurement	ZBTB41 F13A1	3.63e-03	20	133	2	EFO_0004634
Disease	Deep Vein Thrombosis	F8 F13A1	4.00e-03	21	133	2	C0149871
Disease	Venous Thrombosis	F8 F13A1	4.00e-03	21	133	2	C0042487
Disease	gastric ulcer (biomarker_via_orthology)	FAS F13A1	4.00e-03	21	133	2	DOID:10808 (biomarker_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	MARS2 PON1 PSMD2 GRIK3	4.27e-03	145	133	4	DOID:1289 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETDHKHDVYWKSFNQ	ZNF286A	186	Q9HBT8
VTWAVHQALHGKKDF	ALS2CL	311	Q60I27
HIEWAKKNTARAYHL	ERLEC1	386	Q96DZ1
EVKEHSFFKGVDWQH	GRK3	446	P35626
FWKEHHFEGIALVEK	AKR7L	236	Q8NHP1
YWKEHHFEGIALVEK	AKR7A3	236	O95154
KWDVTVLELSYHKRH	CDC73	491	Q6P1J9
SLWKYHTHLLQFDGE	ABCD2	666	Q9UBJ2
NYHKLHWETEFKPVA	ARMC2	831	Q8NEN0
HWNKTIHGLIYNALK	PPP2R5C	381	Q13362
AKVHGSYEHLWAGQV	CAPN10	156	Q9HC96
SKYKHVKDHIWSQEE	DHTKD1	851	Q96HY7
IHFLTWYKENLHKLE	CD180	586	Q99467
NGKDHRDWDHYKQDS	CHD1	1581	O14646
KTVYTGIDHHWKEAV	DCAF13	156	Q9NV06
YWLQHTETKAKLHHL	ASTE1	471	Q2TB18
IEKNSWSGIEDYFHH	GRAMD1A	511	Q96CP6
QWVHGIVVYTGHDTK	ATP8A1	261	Q9Y2Q0
KKKLYAHEVVAHWIA	ACAD11	661	Q709F0
DAIYDHINEGKLWKH	UQCR10	41	Q9UDW1
YDRLHKKINHAWDLV	RGS11	146	O94810
HKLEPEAWKHVEAVY	PITPNA	126	Q00169
KWFSQHNHLKADYEK	PIK3C2G	996	O75747
AHIYWAHFKETLALE	MOB2	156	Q70IA6
LNDHGKNWRHVYKSL	ENTHD1	61	Q8IYW4
KNWVYSHDGVSLHEL	FXN	171	Q16595
LSKWKGDYEKLEHNH	OGFRL1	141	Q5TC84
KEDGKHHEVNVQFSW	MAN2A1	781	Q16706
DWDQTRGDHVKHYKI	FGR	186	P09769
DHGKNWRHVYKALTL	EPN2	66	O95208
VAVYHSASKQKAWDH	ENOX2	336	Q16206
RQNCSHDWGIHVKYK	DDX58	866	O95786
HDWGIHVKYKTFEIP	DDX58	871	O95786
YKDLAWKHGNIHLSA	PCMTD1	51	Q96MG8
YKDLAWKHGNIHLSA	PCMTD2	51	Q9NV79
DLLQAFVEHWKGITH	FHIP2B	21	Q86V87
SISRDWHGYKKKNHT	PDZD9	181	Q8IXQ8
WQKGKEHHHLAVAYS	PEAR1	781	Q5VY43
WANHYLAKSGHKRLI	NAV3	86	Q8IVL0
QKLHWNPEDKGYVLH	DRAM2	191	Q6UX65
DHAWIKVEQLKPYHA	GLYR1	51	Q49A26
NWLGYILDDHKIQHL	DDX28	411	Q9NUL7
EKFYRIKTHHSNDIW	LACC1	241	Q8IV20
LGKDWTHQGIAKLYH	LPIN1	696	Q14693
LIKAHAEAWHLYNDV	LCT	1571	P09848
ERWDTNKVDHHTDKY	F13A1	56	P00488
KHPKTWVHYIAAEEE	F8	396	P00451
LKDYEAWLGIHDVHG	HGF	541	P14210
SDYKHHWSDVLVGLL	PLPP2	216	O43688
EHIYHLKVKSQDWFD	OSBPL6	156	Q9BZF3
IGSKHEKDTWLYHLT	PLEKHH2	901	Q8IVE3
EGKDYALHWLVLGTH	RBBP7	56	Q16576
KLHYDKSHDQVWVLS	FSTL5	546	Q8N475
SWYKDGKAVQVDPHH	OBSCN	6046	Q5VST9
WHLKNAIRVDGKIYH	PCF11	1461	O94913
HTLLQVYFLWGHAKD	OTOP1	176	Q7RTM1
EVWKFGNVVIEHLYH	EFCAB5	1446	A4FU69
AAIWGYSHKDEVIKE	CD9	106	P21926
SVYRSAKKWNEEHLH	DNAH3	331	Q8TD57
HENIYLWDIHNAKVK	DOK6	161	Q6PKX4
QKYSLEQIHWEVSKH	FBXL3	401	Q9UKT7
DGVKYSAELHVAHWN	CA1	111	P00915
HSGYVQIDWKRVEKD	FUNDC1	91	Q8IVP5
ELWKEHRDQHDLTYG	CYP27A1	131	Q02318
VHPEDHKLNKYHDWL	MBD4	556	O95243
NWVLTAAHAVYEQKH	MASP2	476	O00187
DHYHWKDLNRGINIT	EFHC1	161	Q5JVL4
HLVHWNAKKYSTFGE	CA7	121	P43166
EFHVTPEKNKQYHVW	CCDC168	6721	Q8NDH2
RWKHHPLDNKDTFYV	GRIK3	136	Q13003
EKWIYVHKGSTKERH	FBXO32	81	Q969P5
HDFLGAYKLQHDLSW	C1orf50	146	Q9BV19
FKKHGAEHYWDLALS	PRPF3	661	O43395
TDKAVNHIWKIYHNG	PRDM4	456	Q9UKN5
THHSIELYWDLEKKA	FANK1	21	Q8TC84
NDHGKQYSDGKWHEI	USH2A	1596	O75445
QYSDGKWHEIIAIRH	USH2A	1601	O75445
HHVWVTKDELGDYLK	MRPL46	251	Q9H2W6
NWHHPEKDKADSYVL	TRIM36	436	Q9NQ86
YDQSKFEEHVESHWK	TAX1BP1	741	Q86VP1
LAHKIHVYEKHANWT	PON1	241	P27169
WSAGIKYHEESIHAA	PLD1	751	Q13393
HEYVRHLAGEVAKEW	PSMD2	156	Q13200
YKHHWSDVLTGLIQG	PLPP1	221	O14494
SHIKVVVGGAEWHYI	PTPN14	966	Q15678
WNILYDKLEKIHHSG	CCT7	271	Q99832
KWALHELKGHYAITR	RNF216	391	Q9NWF9
LKYIGWTLHDKHREV	STAG3L1	46	P0CL83
DHKQKFYWGHKEILI	ACLY	536	P53396
ELLAEHYKHHWFPEK	BTG1	46	P62324
AELHLVHWNTKYGDF	CA2	116	P00918
HPVKSGIHKWISDYA	RRP7A	146	Q9Y3A4
HIKQQLWSEECYHGK	SHC4	516	Q6S5L8
EGKVKETVHNAFWDH	TCP11	81	Q8WWU5
YLSWEGTAEEHKAHI	TBC1D17	326	Q9HA65
LYIHSKKHLQDVDTW	ZXDB	531	P98169
NCLKNVVIWYEDHKH	ZNF653	121	Q96CK0
HLHSQLEVSYGKQWD	nan	171	Q6ZTK2
HHEWYLKIQLEDIKN	VPS11	511	Q9H270
SKYHISVAEEGNDKW	VPS13A	2321	Q96RL7
ENFRHVVHKWHYKLT	THOC2	1091	Q8NI27
VVHKWHYKLTKASVH	THOC2	1096	Q8NI27
VDIAKKHILIYEQHW	TRPM6	421	Q9BX84
LEHWDVNKRDYIGTH	ZP1	216	P60852
ALTGQKWQHKHITYS	MMP16	121	P51512
WHQLHGKKEAYDTLI	FAS	281	P25445
KVDEQWYHGELHGTQ	SH3RF3	226	Q8TEJ3
YHEELWKLNFQHLSG	TMEM232	21	C9JQI7
AHLGKWQKLEHGSYS	TMEM39A	351	Q9NV64
EHCKGKSDHYWVVGI	WDHD1	666	O75717
SGHQWVDVHGVQKDY	PRSS35	371	Q8N3Z0
VLGLHCYKKGIHYWE	TRIM25	501	Q14258
IDIWGKHHIYDKTSV	ZNF267	181	Q14586
LTVHYKSVHLGEKVW	ZBTB41	646	Q5SVQ8
WYTDLNQHKKIHTGE	ZNF721	136	Q8TF20
GHYIAIVKSHDFWLL	USP12	316	O75317
IDGHIAEHNSKIKYW	SMC4	1021	Q9NTJ3
AEHNSKIKYWHKEIS	SMC4	1026	Q9NTJ3
LKYIGWTLHDKHREV	STAG3L2	46	P0CL84
SYQKHQISRDHGWIK	VPS13C	3141	Q709C8
IVYIHKEVDKNWLEG	SORBS3	406	O60504
LHFKVKWLHNEYVRD	UNC13B	1036	O14795
LWGFHTKLNDCHKVY	TMEM168	316	Q9H0V1
IHWHLLGDLQFKSYV	PKHD1L1	2476	Q86WI1
HIIGKDILKFHAIYW	MARS2	306	Q96GW9
KLWSLHEHNKIVHGY	ZBTB47	501	Q9UFB7
LLIGTKHEKDTWLYH	PLEKHH1	776	Q9ULM0
KHEKDTWLYHLTVAA	PLEKHH1	781	Q9ULM0
KELLFHHEWVVKESG	TNPO1	411	Q92973
KVTHDHKDGIVEFNW	TOP3A	271	Q13472
WKRYHIKVHLADEAL	TINCR	11	A0A2R8Y7D0
DKYHKNTALHWAVLA	ZDHHC17	221	Q8IUH5
SAVHKWGTEIHEGIY	USP24	191	Q9UPU5
LHIHWRDHTGEKVYK	ZNF664	46	Q8N3J9
HQRGHSRDKTYKWEV	ZNF233	416	A6NK53
LKYIGWTLHDKHREV	STAG3L3	46	P0CL85
QHWRIHTGEKLYKCN	ZNF766	316	Q5HY98
IASGSEDHKVYIWHK	WDR26	586	Q9H7D7
HANIWDILGIHSKYD	UGGT2	586	Q9NYU1
KKREEDGHTHQWTVY	YEATS4	36	O95619
KVKWARENYHHNIGS	WDR11	66	Q9BZH6
QKLDHVWTDTHYVGL	TFR2	186	Q9UP52
AYADLVKQAWSGHHR	USP11	361	P51784
CHIKKEGRWVIYNDH	USP13	826	Q92995
REIKHKNIVTFHEWY	ULK4	51	Q96C45
WTHQGIAKLYHSINE	LPIN2	711	Q92539
KHIYAQLFGWIVEHI	MYO5B	406	Q9ULV0
YLDKREVHHKNWHEV	MYOM2	746	P54296
HLYKQAWEADKTKVH	NEB	1991	P20929