Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ADP binding	MAT1A ME1 RUVBL2 PGK1 ATP5F1A	3.67e-05	48	157	5	GO:0043531
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	6.14e-05	2	157	2	GO:0004478
GeneOntologyMolecularFunction	glucosamine-6-phosphate deaminase activity	GNPDA1 GNPDA2	6.14e-05	2	157	2	GO:0004342
GeneOntologyMolecularFunction	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	GMPR2 GMPR	6.14e-05	2	157	2	GO:0046857
GeneOntologyMolecularFunction	GMP reductase activity	GMPR2 GMPR	6.14e-05	2	157	2	GO:0003920
GeneOntologyBiologicalProcess	platelet activating factor biosynthetic process	PLA2G4C LPCAT2 PLA2G4A	4.04e-06	5	154	3	GO:0006663
GeneOntologyBiologicalProcess	protein retention in Golgi apparatus	VPS13C VPS13D VPS13A	4.04e-06	5	154	3	GO:0045053
GeneOntologyBiologicalProcess	cellular catabolic process	GALC GNPDA1 ASRGL1 AUH MAT1A VPS13C GPX1 WNK1 PGAM5 PM20D2 GGT5 DUOX1 VPS13D OXCT1 PLA2G4C WDR6 ALDH1L2 GNPDA2 GLS VPS13A PLA2G4A ATP6V0D2 SMPD3 RMC1 SORD	6.31e-06	1253	154	25	GO:0044248
GeneOntologyBiologicalProcess	small molecule catabolic process	GNPDA1 ASRGL1 AUH MAT1A PGK1 PM20D2 ADH7 GK2 OXCT1 ALDH1L2 GNPDA2 GLS SORD	1.72e-05	421	154	13	GO:0044282
GeneOntologyBiologicalProcess	platelet activating factor metabolic process	PLA2G4C LPCAT2 PLA2G4A	3.32e-05	9	154	3	GO:0046469
GeneOntologyBiologicalProcess	glucosamine catabolic process	GNPDA1 GNPDA2	5.54e-05	2	154	2	GO:0006043
GeneOntologyBiologicalProcess	ether lipid biosynthetic process	PLA2G4C LPCAT2 PLA2G4A	1.10e-04	13	154	3	GO:0008611
GeneOntologyBiologicalProcess	glycerol ether biosynthetic process	PLA2G4C LPCAT2 PLA2G4A	1.10e-04	13	154	3	GO:0046504
GeneOntologyBiologicalProcess	phosphatidylcholine acyl-chain remodeling	PLA2G4C LPCAT2 PLA2G4A	1.40e-04	14	154	3	GO:0036151
GeneOntologyBiologicalProcess	ether biosynthetic process	PLA2G4C LPCAT2 PLA2G4A	1.40e-04	14	154	3	GO:1901503
GeneOntologyBiologicalProcess	positive regulation of platelet activation	FLNA SVEP1 PLA2G4A	1.40e-04	14	154	3	GO:0010572
GeneOntologyBiologicalProcess	modified amino acid catabolic process	PM20D2 GGT5 PCYOX1L ALDH1L2	1.63e-04	37	154	4	GO:0042219
GeneOntologyBiologicalProcess	fructose biosynthetic process	GNPDA1 SORD	1.65e-04	3	154	2	GO:0046370
GeneOntologyBiologicalProcess	N-acetylglucosamine catabolic process	GNPDA1 GNPDA2	1.65e-04	3	154	2	GO:0006046
GeneOntologyBiologicalProcess	organic acid catabolic process	GNPDA1 ASRGL1 AUH MAT1A PM20D2 ALDH1L2 GNPDA2 GLS SORD	2.12e-04	272	154	9	GO:0016054
GeneOntologyBiologicalProcess	carboxylic acid catabolic process	GNPDA1 ASRGL1 AUH MAT1A PM20D2 ALDH1L2 GNPDA2 GLS SORD	2.12e-04	272	154	9	GO:0046395
GeneOntologyBiologicalProcess	nucleotide-sugar metabolic process	GNPDA1 GNPDA2 TGDS GMPPA	3.22e-04	44	154	4	GO:0009225
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription	SCAF8 WNK1	3.29e-04	4	154	2	GO:1904594
GeneOntologyBiologicalProcess	S-adenosylmethionine biosynthetic process	MAT1A MAT2A	3.29e-04	4	154	2	GO:0006556
GeneOntologyBiologicalProcess	organophosphate biosynthetic process	ADCY4 HMGCS1 GMPR2 MDH2 ME1 PGK1 GK2 PLA2G4C LPCAT2 SLC25A1 PLA2G4A GMPR ATP5F1A SORD	3.44e-04	644	154	14	GO:0090407
GeneOntologyCellularComponent	GMP reductase complex	GMPR2 GMPR	5.68e-05	2	158	2	GO:1902560
GeneOntologyCellularComponent	methionine adenosyltransferase complex	MAT1A MAT2A	1.69e-04	3	158	2	GO:0048269
Domain	VPS13	VPS13C VPS13D VPS13A	5.50e-07	3	154	3	IPR026847
Domain	VPS13_mid_rpt	VPS13C VPS13D VPS13A	5.50e-07	3	154	3	PF16910
Domain	VPS13	VPS13C VPS13D VPS13A	5.50e-07	3	154	3	PF16908
Domain	VPS13_N2	VPS13C VPS13D VPS13A	5.50e-07	3	154	3	IPR031646
Domain	VPS13_mid_rpt	VPS13C VPS13D VPS13A	5.50e-07	3	154	3	IPR031642
Domain	Filamin	FLNA FLNB FLNC MYCBP2	1.40e-06	11	154	4	PF00630
Domain	FILAMIN_REPEAT	FLNA FLNB FLNC MYCBP2	1.40e-06	11	154	4	PS50194
Domain	Filamin/ABP280_rpt	FLNA FLNB FLNC MYCBP2	1.40e-06	11	154	4	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNA FLNB FLNC MYCBP2	1.40e-06	11	154	4	IPR017868
Domain	SHR-BD	VPS13C VPS13D VPS13A	2.19e-06	4	154	3	IPR009543
Domain	VPS13_C	VPS13C VPS13D VPS13A	2.19e-06	4	154	3	PF16909
Domain	VPS13_C	VPS13C VPS13D VPS13A	2.19e-06	4	154	3	IPR031645
Domain	SHR-BD	VPS13C VPS13D VPS13A	2.19e-06	4	154	3	PF06650
Domain	Ig_E-set	FLNA FLNB FLNC MYCBP2 PLXNB2 TGM1 PLXNB1	2.46e-05	104	154	7	IPR014756
Domain	Chorein_N	VPS13C VPS13D VPS13A	2.99e-05	8	154	3	PF12624
Domain	VPS13_N	VPS13C VPS13D VPS13A	2.99e-05	8	154	3	IPR026854
Domain	IG_FLMN	FLNA FLNB FLNC	6.32e-05	10	154	3	SM00557
Domain	S-AdoMet_synt_N	MAT1A MAT2A	6.75e-05	2	154	2	PF00438
Domain	Glucosamine6P_isomerase_CS	GNPDA1 GNPDA2	6.75e-05	2	154	2	IPR018321
Domain	Glucosamine6P_isomerase	GNPDA1 GNPDA2	6.75e-05	2	154	2	IPR004547
Domain	S-AdoMet_synthetase	MAT1A MAT2A	6.75e-05	2	154	2	IPR002133
Domain	GLC_GALNAC_ISOMERASE	GNPDA1 GNPDA2	6.75e-05	2	154	2	PS01161
Domain	S-AdoMet_synt_M	MAT1A MAT2A	6.75e-05	2	154	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	6.75e-05	2	154	2	PF02773
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	6.75e-05	2	154	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	6.75e-05	2	154	2	IPR022630
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	6.75e-05	2	154	2	IPR022636
Domain	S-AdoMet_synt_central	MAT1A MAT2A	6.75e-05	2	154	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	6.75e-05	2	154	2	IPR022628
Domain	GMPR	GMPR2 GMPR	6.75e-05	2	154	2	IPR005993
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	6.75e-05	2	154	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	6.75e-05	2	154	2	PS00377
Domain	IMPDH	GMPR2 GMPR	4.01e-04	4	154	2	PF00478
Domain	IMP_DH_GMPRt	GMPR2 GMPR	4.01e-04	4	154	2	IPR001093
Domain	IMP_DH_GMP_RED	GMPR2 GMPR	4.01e-04	4	154	2	PS00487
Domain	IMP_DH/GMP_Rdtase_CS	GMPR2 GMPR	4.01e-04	4	154	2	IPR015875
Domain	Glc/Gal-6P_isomerase	GNPDA1 GNPDA2	4.01e-04	4	154	2	IPR006148
Domain	Glucosamine_iso	GNPDA1 GNPDA2	4.01e-04	4	154	2	PF01182
Domain	-	NOXRED1 UBA3 MDH2 ME1 ADH7 TGDS SORD	5.11e-04	169	154	7	3.40.50.720
Domain	NAD(P)-bd_dom	NOXRED1 UBA3 MDH2 ME1 ADH7 TGDS SORD	5.87e-04	173	154	7	IPR016040
Domain	Autophagy-rel_C	VPS13C VPS13A	6.65e-04	5	154	2	IPR015412
Domain	ATG_C	VPS13C VPS13A	6.65e-04	5	154	2	PF09333
Domain	Ig-like_fold	FLNA FLNB COL6A3 FLNC MYCBP2 SPEG NRG2 VSIG10 PLXNB2 HAVCR1 TGM1 IGHD SLAMF7 PLXNB1 ADGRA3	7.51e-04	706	154	15	IPR013783
Domain	ACTININ_2	FLNA FLNB FLNC	8.63e-04	23	154	3	PS00020
Domain	ACTININ_1	FLNA FLNB FLNC	8.63e-04	23	154	3	PS00019
Domain	Actinin_actin-bd_CS	FLNA FLNB FLNC	8.63e-04	23	154	3	IPR001589
Domain	-	FLNA FLNB COL6A3 FLNC MYCBP2 SPEG NRG2 VSIG10 PLXNB2 HAVCR1 TGM1 SLAMF7 PLXNB1 ADGRA3	1.20e-03	663	154	14	2.60.40.10
Domain	AAA	ABCC5 RUVBL2 ABCC6 MDN1 DNAH9 YME1L1	1.25e-03	144	154	6	SM00382
Domain	AAA+_ATPase	ABCC5 RUVBL2 ABCC6 MDN1 DNAH9 YME1L1	1.25e-03	144	154	6	IPR003593
Domain	PLA2_B	PLA2G4C PLA2G4A	1.38e-03	7	154	2	PF01735
Domain	PLA2C	PLA2G4C PLA2G4A	1.38e-03	7	154	2	PS51210
Domain	LysoPLipase_cat_dom	PLA2G4C PLA2G4A	1.38e-03	7	154	2	IPR002642
Domain	PLAc	PLA2G4C PLA2G4A	1.38e-03	7	154	2	SM00022
Domain	ADH_Zn_CS	ADH7 SORD	1.83e-03	8	154	2	IPR002328
Domain	ADH_ZINC	ADH7 SORD	1.83e-03	8	154	2	PS00059
Domain	Helicase/UvrB_N	ERCC3 SBNO1	1.83e-03	8	154	2	IPR006935
Domain	ResIII	ERCC3 SBNO1	1.83e-03	8	154	2	PF04851
Domain	CH	FLNA FLNB FLNC LRCH4	2.04e-03	65	154	4	SM00033
Domain	Plexin_cytopl	PLXNB2 PLXNB1	2.34e-03	9	154	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNB2 PLXNB1	2.34e-03	9	154	2	IPR013548
Domain	Plexin	PLXNB2 PLXNB1	2.34e-03	9	154	2	IPR031148
Domain	Ntn_hydrolases_N	ASRGL1 PSMA2 GGT5	2.50e-03	33	154	3	IPR029055
Domain	CH	FLNA FLNB FLNC LRCH4	2.67e-03	70	154	4	PF00307
Domain	-	FLNA FLNB FLNC LRCH4	2.81e-03	71	154	4	1.10.418.10
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	FLNA FLNB FLNC GNPDA1 RPLP2 MAP4 MAT2A PSMA2 GPX1 CAST UBA3 GMPR2 ECPAS WNK1 ME1 RUVBL2 RCC2 AARSD1 USP19 OXCT1 SBNO1 AHNAK GNPDA2 GLS PLA2G4A SDF2L1 IRF2BPL EIF3J GMPPA FUBP3 SORD	7.12e-13	1455	159	31	22863883
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNA FLNB FLNC RPLP2 MYCBP2 MAP4 CDK12 MAT2A PSMA2 CAST HMGCS1 MDH2 ECPAS ME1 RUVBL2 PGK1 BANF1 RCC2 PCYOX1L MDN1 FAM120A AHNAK SDF2L1 EIF3J RPL5 ATP5F1A	1.75e-11	1149	159	26	35446349
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNA FLNB FLNC ERCC3 RPLP2 MYCBP2 MAP4 MAT2A PSMA2 RUVBL2 PGAM5 SLC1A5 PGK1 AARSD1 TGM1 OXCT1 MDN1 FAM120A WDR6 SLC25A1 AHNAK GLS YME1L1 FUBP3 RPL5 ATP5F1A SORD	1.15e-10	1353	159	27	29467282
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	FLNA FLNB FLNC MLEC MYCBP2 PSMA2 PCDHA8 MUC5B MDH2 ECPAS ME1 RUVBL2 SLC1A5 PGK1 DUOX1 MDN1 SLC25A1 AHNAK RPL5 ATP5F1A SORD	1.52e-10	807	159	21	30575818
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNA FLNB ADCY4 MLEC RPLP2 MAP4 VPS13C MAT2A MDH2 ECPAS RUVBL2 PGAM5 SLC1A5 PGK1 RCC2 USP19 MDN1 FAM120A SBNO1 WDR6 GLS MYO18B FUBP3 RPL5 ATP5F1A ADGRA3 CDK4	3.59e-10	1425	159	27	30948266
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	FLNA FLNB FLNC MAP4 PPFIA4 CAST AIRE PCDHA8 PCDHA6 RRAS TGDS VPS13A MYO18B FUBP3	4.27e-10	329	159	14	17474147
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	FLNA FLNB FLNC RPLP2 MAP4 PSMA2 ITGA5 MDH2 ECPAS RUVBL2 PGAM5 PGK1 RCC2 MDN1 SLC25A1 AHNAK FUBP3 RPL5 ATP5F1A	7.13e-10	707	159	19	19738201
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	FLNA FLNB FLNC MAP4 MAT2A SQLE MUC5B HMGCS1 MDH2 ECPAS WNK1 PLXNB2 RUVBL2 PGK1 RCC2 AARSD1 USP19 TGM1 OXCT1 SLC25A1 AHNAK IRF2BPL EIF3J FUBP3 RPL5 ATP5F1A	7.33e-10	1367	159	26	32687490
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNA FLNB FLNC RPLP2 MYCBP2 MAP4 ECPAS PGAM5 PGK1 RCC2 MDN1 FAM120A WDR6 AHNAK FUBP3 RPL5	6.08e-08	653	159	16	22586326
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	FLNA ERCC3 RPLP2 MAP4 MAT2A PSMA2 GPX1 HMGCS1 MDH2 ME1 RUVBL2 AHDC1 PGAM5 PGK1 RCC2 TNRC18 FAM120A SLC25A1 EIF3J GMPPA RPL5 ATP5F1A	6.41e-08	1247	159	22	27684187
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNA FLNB FLNC MAT2A HMGCS1 ITGA5 MDH2 WNK1 PGK1 MDN1 FAM120A SDF2L1	7.03e-08	344	159	12	30333137
Pubmed	Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.	FLNA FLNB FLNC	9.38e-08	3	159	3	12393796
Pubmed	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.	FLNA FLNB FLNC	9.38e-08	3	159	3	11153914
Pubmed	Filamins as integrators of cell mechanics and signalling.	FLNA FLNB FLNC	9.38e-08	3	159	3	11252955
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	FLNA FLNB MLEC CDK12 MAT2A HMGCS1 MDH2 ECPAS RUVBL2 PGAM5 SLC1A5 USP19 SLC25A1 GLS GMPPA ATP5F1A CDK4 SORD	1.27e-07	878	159	18	37223481
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLNA FLNB FLNC PPFIA4 PSMA2 EML6 SHB RBM42 ABCC5 MDH2 PGAM5 PGK1 BANF1 TNRC18 MDN1 SBNO1 SLC25A1 AHNAK GLS VPS13A FUBP3 ATP5F1A RBBP9	1.89e-07	1442	159	23	35575683
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	FLNA FLNC RPLP2 MAP4 MAT2A RUVBL2 SLC1A5 MDN1 WDR6 ALDH1L2 SLC25A1 SDF2L1 GMPPA RPL5 ATP5F1A CDK4	2.49e-07	725	159	16	27025967
Pubmed	Hypoxia-mediated promotion of glucose metabolism in non-small cell lung cancer correlates with activation of the EZH2/FBXL7/PFKFB4 axis.	HMGCS1 RUVBL2 GMPPA ATP5F1A	2.91e-07	13	159	4	37179372
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	FLNA FLNB FLNC MAP4 CDK12 VPS13C PSMA2 RUVBL2 PGK1 VPS13D OXCT1 LPCAT2 OSR1 ATP5F1A	3.63e-07	564	159	14	21565611
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	FLNA FLNB FLNC MLEC RPLP2 MAT2A SLC1A5 PGK1 RCC2 TGM1 SLC25A1 AHNAK GLS SDF2L1 FUBP3 RPL5 ATP5F1A	3.70e-07	844	159	17	25963833
Pubmed	The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.	FLNA FLNB FLNC	3.74e-07	4	159	3	11739414
Pubmed	Structural interaction and functional regulation of polycystin-2 by filamin.	FLNA FLNB FLNC	3.74e-07	4	159	3	22802962
Pubmed	Analysis of the human VPS13 gene family.	VPS13C VPS13D VPS13A	3.74e-07	4	159	3	15498460
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	FLNA FLNB RPLP2 MAP4 RRAS PGAM5 PGK1 BANF1 RCC2 FAM120A SLC25A1 AHNAK RPL5 ATP5F1A	5.06e-07	580	159	14	35676659
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	RPLP2 MAP4 ECPAS RUVBL2 PGAM5 PGK1 RCC2 TGM1 SLC25A1 AHNAK FUBP3 RPL5	5.65e-07	418	159	12	35338135
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNA FLNB FLNC MLEC MAT2A PSMA2 GPX1 ECPAS PTPN18 PGAM5 SLC1A5 RCC2 FAM120A WDR6 SDF2L1 YME1L1 FUBP3 RPL5	5.73e-07	974	159	18	28675297
Pubmed	Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.	FLNA FLNB FLNC	9.31e-07	5	159	3	12006559
Pubmed	Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.	FLNA FLNB FLNC	9.31e-07	5	159	3	17360453
Pubmed	HIV infection of T cells: actin-in and actin-out.	FLNA FLNB FLNC	9.31e-07	5	159	3	19366992
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	MAT2A RBM42 UBA3 HMGCS1 ME1 RUVBL2 PGK1 AARSD1 PM20D2 OXCT1 GLS YME1L1 FUBP3 RPL5 ATP5F1A	9.34e-07	704	159	15	32994395
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	METTL3 ERCC3 MAP4 CDK12 MAT2A PSMA2 TRPS1 ECPAS RUVBL2 PGK1 BANF1 MDN1 SBNO1 AHNAK IRF2BPL EIF3J FUBP3 SORD	1.02e-06	1014	159	18	32416067
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FLNA FLNC RPLP2 MYCBP2 MAP4 MAT2A MDH2 ECPAS RUVBL2 PGAM5 RCC2 MDN1 FAM120A AHNAK RPL5 ATP5F1A	1.06e-06	809	159	16	32129710
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNA FLNB FLNC RPLP2 MYCBP2 MAP4 MDH2 PLXNB2 RUVBL2 PGAM5 SLC1A5 PGK1 RCC2 MDN1 AHNAK FUBP3 RPL5 ATP5F1A	1.17e-06	1024	159	18	24711643
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FLNA FLNB FLNC MAP4 MDH2 RUVBL2 PGAM5 PGK1 FAM120A ANGEL2 FUBP3 RPL5 ATP5F1A	1.69e-06	551	159	13	34728620
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	FLNB RPLP2 MAT2A PSMA2 CAST MDH2 RUVBL2 PGK1 MDN1 AHNAK GMPPA YME1L1 RPL5 ATP5F1A	1.83e-06	647	159	14	26618866
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	FLNA FLNB ERCC3 RPLP2 MAP4 MAT1A MAT2A PGAM5 RCC2 NEDD9 TGM1 FAM120A SLC25A1 AHNAK RPL5 ATP5F1A ADGRA3	1.83e-06	949	159	17	36574265
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	FLNA FLNB RPLP2 MAP4 SCAF8 MAT2A CAST TACC2 MDH2 WNK1 RUVBL2 PGAM5 PGK1 RCC2 SBNO1 SLC25A1 AHNAK SDF2L1 EIF3J RPL5 ATP5F1A	2.13e-06	1415	159	21	28515276
Pubmed	Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.	FLNA FLNB FLNC AHNAK ATP5F1A	2.21e-06	46	159	5	33403043
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	FLNA FLNB RPLP2 MAP4 CDK12 MAT2A SPEG PSMA2 CAST RBM42 USP37 RUVBL2 PGAM5 BANF1 RCC2 FAM120A ALDH1L2	2.49e-06	971	159	17	33306668
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	FLNA FLNB MLEC PSMA2 MDH2 ECPAS PGAM5 SLC1A5 BANF1 RCC2 OXCT1 MDN1 FAM120A WDR6 AHNAK SDF2L1 IRF2BPL EIF3J FUBP3 ATP5F1A CDK4	2.80e-06	1440	159	21	30833792
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	FLNA FLNB FLNC GNPDA1 MAP4 MDH2 AHNAK ATP5F1A	2.98e-06	191	159	8	33762435
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	FLNA FLNC MAT2A PSMA2 SQLE ECPAS SLC1A5 SLC25A1 VPS13A RPL5 ATP5F1A	3.10e-06	408	159	11	33766124
Pubmed	Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.	RPLP2 MAP4 PGK1 BANF1 FAM120A RPL5 ATP5F1A	3.10e-06	135	159	7	31405213
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	FLNA FLNB FLNC RPLP2 MAP4 MDH2 ECPAS RUVBL2 PGK1 FAM120A AHNAK RPL5	3.19e-06	494	159	12	26831064
Pubmed	The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.	FLNA FLNB FLNC	3.24e-06	7	159	3	16076904
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	FLNA FLNB RPLP2 MAP4 MAT2A PSMA2 UBA3 RUVBL2 PGK1 EIF3J RPL5 ATP5F1A	3.26e-06	495	159	12	28581483
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	FLNA FLNB GNPDA1 MAP4 CDK12 ECPAS RUVBL2 RCC2 AARSD1 SLC25A1 AHNAK RPL5	3.47e-06	498	159	12	36634849
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	FLNA FLNC ASRGL1 MAP4 MAT2A GPX1 CAST UBA3 AMER2 ATP5F1A	4.22e-06	341	159	10	29791485
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	FLNA FLNB COL6A3 GNPDA1 VPS13C PSMA2 CDHR5 RRAS MDH2 VPS13D GK2 SLC25A1 AHNAK ATP6V0D2 MBD5 ATP5F1A SORD	4.54e-06	1016	159	17	19056867
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	FLNA FLNB MAP4 SLC1A5 AHNAK	4.95e-06	54	159	5	25631074
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	AUH MYCBP2 VPS13C PSMA2 TACC2 MDH2 PLXNB2 PGAM5 USP19 VPS13D OXCT1 MDN1 FAM120A WDR6 ALDH1L2 ANGEL2 GLS VPS13A YME1L1 FUBP3 ATP5F1A	5.05e-06	1496	159	21	32877691
Pubmed	MEKK4 signaling regulates filamin expression and neuronal migration.	FLNA FLNB FLNC	5.16e-06	8	159	3	17145501
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FLNA FLNB METTL3 ERCC3 RPLP2 MAP4 MAT2A RUVBL2 PGAM5 PGK1 RCC2 FAM120A WDR6 SLC25A1 AHNAK ANGEL2 GLS RPL5 ATP5F1A	5.23e-06	1257	159	19	36526897
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	FLNA FLNB METTL3 RPLP2 MAP4 MAT2A SQLE GPX1 ECPAS RUVBL2 RCC2 FUBP3 RPL5 ATP5F1A	5.40e-06	711	159	14	33022573
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	AVEN FLNA FLNC ERCC3 MYCBP2 MAP4 CAST RUVBL2 FAM120A LPCAT2 WDR6 AHNAK FUBP3 RPL5	6.63e-06	724	159	14	36232890
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	FLNA FLNB MAP4 PGK1 AHNAK FUBP3 ATP5F1A	6.79e-06	152	159	7	16009940
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	FLNA FLNB FLNC MAP4 TRPS1 RUVBL2 AHNAK PAN3	7.13e-06	215	159	8	35973513
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	FLNA FLNB RPLP2 PSMA2 CAST UBA3 PGK1 AARSD1 MDN1 AHNAK MYO18B RPL5	7.57e-06	538	159	12	28524877
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	FLNA FLNB FLNC	7.72e-06	9	159	3	11807098
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FLNA FLNB MLEC RPLP2 MYCBP2 MAT2A ITGA5 MDH2 WNK1 PLXNB2 SLC1A5 PM20D2 FAM120A WDR6 AHNAK GLS SDF2L1 ATP5F1A SORD	8.15e-06	1297	159	19	33545068
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	FLNA FLNB FLNC RPLP2 MAT2A PSMA2 MDH2 WNK1 RUVBL2 PGK1 BANF1 MDN1 LPCAT2 RPL5 ATP5F1A	8.76e-06	847	159	15	35235311
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	MAP4 RUVBL2 FAM120A AHNAK FUBP3 RPL5 ATP5F1A CDK4	9.31e-06	223	159	8	20020773
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	FLNA FLNB MAP4 CDK12 CAST EIF3J GMPPA DNAH9	1.03e-05	226	159	8	31452512
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	FLNA FLNC RPLP2 MAT2A MDH2 RUVBL2 PGAM5 PGK1 TGM1 AHNAK RPL5 ATP5F1A	1.09e-05	558	159	12	27591049
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	FLNA RPLP2 MAP4 TRPS1 RUVBL2 PGAM5 BANF1 RCC2 TNRC18 FAM120A SLC25A1 RPL5 ATP5F1A	1.09e-05	655	159	13	35819319
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	FLNA FLNB FLNC MLEC RPLP2 RUVBL2 PGAM5 SLC1A5 SLC25A1 RPL5 ATP5F1A	1.13e-05	468	159	11	36042349
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	RPLP2 MAP4 PSMA2 RUVBL2 PGAM5 SLC1A5 RCC2 FAM120A SLC25A1 FUBP3 ATP5F1A	1.15e-05	469	159	11	37314180
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	FLNA MYCBP2 MAP4 MAT2A PSMA2 HMGCS1 ECPAS RUVBL2 AHDC1 PGK1 BANF1 RCC2 TNRC18 FAM120A FUBP3 RPL5 SORD	1.32e-05	1103	159	17	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA FLNC MYCBP2 CDK12 SPEG MLLT10 ITGA5 WNK1 PLXNB2 AHDC1 SLC1A5 BANF1 TNRC18 MDN1 KCNH2 AHNAK MBD5	1.35e-05	1105	159	17	35748872
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	FLNA FLNB FLNC RPLP2 WNK1 VPS13D AHNAK EIF3J	1.36e-05	235	159	8	30258100
Pubmed	Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.	FLNA FLNB FLNC	1.51e-05	11	159	3	36579465
Pubmed	USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.	FLNB FLNC USP19	1.51e-05	11	159	3	19015242
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	FLNA FLNB FLNC PGAM5 RCC2 MDN1 WDR6 SLC25A1 FUBP3 RPL5 ATP5F1A	1.54e-05	484	159	11	31995728
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	FLNB MAP4 PGAM5 BANF1 RCC2 FAM120A EIF3J FUBP3 ATP5F1A	1.59e-05	315	159	9	26777405
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	AVEN FLNA ERCC3 AUH MAP4 CDK12 RBM42 MDH2 RUVBL2 PGAM5 SLC1A5 PGK1 FAM120A WDR6 SLC25A1 AHNAK GPATCH11 FUBP3 ATP5F1A	1.76e-05	1371	159	19	36244648
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	MLEC RPLP2 MYCBP2 MAT2A PSMA2 RUVBL2 PGAM5 SLC1A5 RCC2 MDN1 WDR6 SLC25A1 GMPPA YME1L1 FUBP3 RPL5 ATP5F1A CDK4	1.94e-05	1257	159	18	37317656
Pubmed	A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis.	DDI1 MDN1 ATP5F1A	2.00e-05	12	159	3	30251372
Pubmed	Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study.	GNPDA1 GNPDA2	2.08e-05	2	159	2	12965206
Pubmed	Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin.	GNPDA1 GNPDA2	2.08e-05	2	159	2	12616532
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	2.08e-05	2	159	2	22318685
Pubmed	Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome.	FLNA FLNB	2.08e-05	2	159	2	17635842
Pubmed	R-Ras interacts with filamin a to maintain endothelial barrier function.	FLNA RRAS	2.08e-05	2	159	2	21660952
Pubmed	Functional regulation of semaphorin receptors by proprotein convertases.	PLXNB2 PLXNB1	2.08e-05	2	159	2	12533544
Pubmed	A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.	FLNB FLNC	2.08e-05	2	159	2	9694715
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	2.08e-05	2	159	2	29749642
Pubmed	Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7.	FLNA FLNC	2.08e-05	2	159	2	7689010
Pubmed	Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.	FLNA FLNB	2.08e-05	2	159	2	21325628
Pubmed	Filamin isogene expression during mouse myogenesis.	FLNA FLNC	2.08e-05	2	159	2	10679933
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	2.08e-05	2	159	2	31234428
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	2.08e-05	2	159	2	29448301
Pubmed	A case-control study of genetic association of the PLA2G4A gene with schizophrenia in a Chinese population.	PLA2G4C PLA2G4A	2.08e-05	2	159	2	17417066
Pubmed	Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures.	SLC1A5 SLC7A10	2.08e-05	2	159	2	19382234
Pubmed	A novel structural unit in the N-terminal region of filamins.	FLNA FLNC	2.08e-05	2	159	2	24469451
Pubmed	Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.	VPS13C VPS13A	2.08e-05	2	159	2	17196930
Pubmed	The limits of promiscuity: isoform-specific dimerization of filamins.	FLNB FLNC	2.08e-05	2	159	2	12525170
Pubmed	Structural and functional aspects of filamins.	FLNA FLNB	2.08e-05	2	159	2	11336782
Pubmed	The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.	FLNA FLNB	2.08e-05	2	159	2	33649519
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	2.08e-05	2	159	2	27076759
Pubmed	Intron-less processed Pcdhalpha genes in the central nervous system.	PCDHA8 PCDHA6	2.08e-05	2	159	2	14697259
Pubmed	Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators.	GMPR2 GMPR	2.08e-05	2	159	2	218932
Interaction	BAP1 interactions	FLNA FLNB FLNC KLF8 RPLP2 MYCBP2 MAP4 CDK12 MAT2A PSMA2 CAST HMGCS1 MDH2 ECPAS ME1 RUVBL2 PGAM5 PGK1 BANF1 RCC2 TLX1 PCYOX1L MDN1 FAM120A ALDH1L2 AHNAK SDF2L1 EIF3J MBD5 RPL5 ATP5F1A	1.81e-08	1314	155	31	int:BAP1
Interaction	AGR2 interactions	FLNA FLNB FLNC MLEC MYCBP2 PSMA2 PCDHA8 MUC5B MDH2 ECPAS ME1 RUVBL2 SLC1A5 PGK1 DUOX1 MDN1 SLC25A1 AHNAK RPL5 ATP5F1A SORD	1.00e-05	934	155	21	int:AGR2
Interaction	B3GNT2 interactions	RPLP2 MAP4 HMGCS1 ECPAS RUVBL2 PGAM5 PGK1 RCC2 TGM1 SLC25A1 AHNAK SDF2L1 EIF3J FUBP3 RPL5	1.97e-05	542	155	15	int:B3GNT2
Interaction	PABPC1 interactions	FLNA FLNB FLNC GNPDA1 RPLP2 MAP4 MAT2A CAST RBM42 AIRE RCC2 FAM120A AHNAK PAN3 FUBP3 RPL5 ATP5F1A	2.82e-05	699	155	17	int:PABPC1
Interaction	FN1 interactions	FLNA FLNB FLNC RPLP2 MAP4 PSMA2 ITGA5 MDH2 ECPAS RUVBL2 PGAM5 PGK1 RCC2 MDN1 SLC25A1 AHNAK FUBP3 RPL5 ATP5F1A	2.88e-05	848	155	19	int:FN1
Interaction	SERBP1 interactions	FLNA FLNB MLEC MAP4 CDK12 MAT2A RBM42 UBA3 HMGCS1 MDH2 ECPAS RUVBL2 PGAM5 SLC1A5 RCC2 USP19 FAM120A SLC25A1 GLS MBD5 GMPPA FUBP3 RPL5 ATP5F1A CDK4 SORD	3.52e-05	1432	155	26	int:SERBP1
Interaction	FBXL7 interactions	HMGCS1 RUVBL2 GMPPA ATP5F1A	4.41e-05	26	155	4	int:FBXL7
Interaction	PSMD12 interactions	FLNB FLNC KLF8 MAP4 PSMA2 DDI1 ECPAS RCC2 WDR6 RMC1 ATP5F1A	5.25e-05	331	155	11	int:PSMD12
Interaction	AR interactions	FLNA ERCC3 MYCBP2 VPS13C PSMA2 TRPS1 SHB ECPAS ME1 RUVBL2 AHDC1 PGAM5 PGK1 RCC2 TNRC18 MDN1 SHE IRF2BPL FUBP3 ATP5F1A	7.67e-05	992	155	20	int:AR
Interaction	G3BP1 interactions	FLNA FLNB KLF8 RPLP2 MYCBP2 MAP4 PPM1D HMGCS1 PGAM5 BANF1 RCC2 USP19 FAM120A SLC25A1 EIF3J FUBP3 RPL5 ATP5F1A	7.78e-05	835	155	18	int:G3BP1
Interaction	EEF1A1 interactions	FLNA FLNB METTL3 RPLP2 CDK12 MAT1A PSMA2 RRAS ECPAS RUVBL2 PGK1 RCC2 TNRC18 AHNAK VPS13A RPL5 ATP5F1A	8.22e-05	762	155	17	int:EEF1A1
Cytoband	19q13.3	RRAS RUVBL2 SLC1A5 PLA2G4C NOVA2	1.03e-05	82	159	5	19q13.3
Coexpression	GSE17721_0.5H_VS_12H_CPG_BMDC_UP	GNPDA1 MYCBP2 SPEG OXCT1 FAM120A GMPR GMPPA CDK4 SORD	3.88e-06	200	159	9	M4119
Coexpression	BUSSLINGER_GASTRIC_IMMATURE_PIT_CELLS	FLNB CAST ABCC5 PLXNB2 SLC7A8 FAM120A AHNAK SMPD3	7.88e-06	165	159	8	M40012
Coexpression	ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP	GNPDA1 VPS13C OXCT1 GLS EIF3J SORD	1.25e-05	84	159	6	M2221
Coexpression	GSE12845_IGD_POS_BLOOD_VS_NAIVE_TONSIL_BCELL_UP	FLNA KLF8 SPIB CDHR5 IGHD AHNAK GLS TGDS	2.64e-05	195	159	8	M3184
Coexpression	ZHENG_CORD_BLOOD_C2_PUTATIVE_BASOPHIL_EOSINOPHIL_MAST_CELL_PROGENITOR	FLNA ASRGL1 MLEC HMGCS1 NEDD9 SDF2L1	2.68e-05	96	159	6	M39211
Coexpression	LIAO_METASTASIS	FLNA GNPDA1 ASRGL1 MAP4 VPS13C TRPS1 RRAS VSIG10 RUVBL2 RCC2 SBNO1 KCNH2 GLS	2.72e-05	540	159	13	M13809
Coexpression	GSE29618_LAIV_VS_TIV_FLU_VACCINE_DAY7_BCELL_UP	NRG2 CDHR5 TLX1 DEFB4A DUOX1 GK2 KCNA10 RBBP9	2.95e-05	198	159	8	M5011
Coexpression	TABULA_MURIS_SENIS_KIDNEY_KIDNEY_COLLECTING_DUCT_PRINCIPAL_CELL_AGEING	FLNA MLEC RPLP2 MYCBP2 MAT2A TACC2 TNRC18 AHNAK IRF2BPL ATP6V0D2 RPL5	3.05e-05	394	159	11	MM3724
Coexpression	GSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_UP	FLNB COL6A3 PPFIA4 ITGA5 ITGA9 AHDC1 GLS GMPR	3.05e-05	199	159	8	M8380
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_DN	MAT2A GPX1 HMGCS1 RUVBL2 SLC1A5 PGK1 CDK4 SORD	3.05e-05	199	159	8	M8314
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	FLNA FLNC MLEC MAP4 MAT2A SQLE PLXNB2 SLC1A5 AHNAK	5.02e-05	276	159	9	M3063
Coexpression	GAO_LARGE_INTESTINE_24W_C8_GOBLET_CELL	MUC5B CHGA ERN2 SBNO1	1.11e-04	41	159	4	M39158
Coexpression	BUSSLINGER_GASTRIC_ISTHMUS_CELLS	FLNB MLEC CAST HMGCS1 ME1 SLC7A8 FAM120A AHNAK SDF2L1 SMPD3 EIF3J	1.17e-04	458	159	11	M40010
Coexpression	TRAVAGLINI_LUNG_PROXIMAL_BASAL_CELL	RPLP2 PSMA2 GPX1 ABCC5 MDH2 SLC1A5 PGK1 ADH7 AHNAK RPL5 ATP5F1A CDK4 SORD	1.27e-04	629	159	13	M41652
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	FLNA COL6A3 IFI27L2 MAP4 SPEG ABCC5 PTPN18 PLXNB2 SLC1A5 SVEP1 GGT5 TMEM273 NEDD9 SLC7A8 OXCT1 LPCAT2 PLA2G4A SDF2L1 ATP6V0D2 SLAMF7	1.46e-04	1316	159	20	MM1052
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	FLNA COL6A3 MAP4 SPEG ABCC5 PTPN18 PLXNB2 SLC1A5 SVEP1 GGT5 TMEM273 NEDD9 SLC7A8 OXCT1 LPCAT2 PLA2G4A SDF2L1 ATP6V0D2 SLAMF7	1.98e-04	1242	159	19	M1920
Coexpression	GSE41867_DAY6_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_DN	MAP4 SCAF8 WNK1 TNRC18 SLC25A1 AHNAK CDK4	2.01e-04	196	159	7	M9515
Coexpression	GSE36888_UNTREATED_VS_IL2_TREATED_STAT5_AB_KNOCKIN_TCELL_2H_DN	SPIB RPLP2 MAT2A TGDS SMPD3 SLAMF7 MBD5	2.01e-04	196	159	7	M8757
Coexpression	GSE43863_NAIVE_VS_TFH_CD4_EFF_TCELL_D6_LCMV_UP	FLNA FLNB SQLE RRAS ITGA5 SHE ATP5F1A	2.07e-04	197	159	7	M9725
Coexpression	GSE26559_TCF1_KO_VS_WT_LIN_NEG_CELL_UP	FLNA MLEC MAP4 CAST RBM42 GLS FUBP3	2.14e-04	198	159	7	M8423
Coexpression	GSE42724_NAIVE_BCELL_VS_PLASMABLAST_DN	GNPDA1 ASRGL1 MLEC SHB PLA2G4A SLC25A48 CDK4	2.14e-04	198	159	7	M9800
Coexpression	GSE36888_STAT5_AB_KNOCKIN_VS_WT_TCELL_IL2_TREATED_2H_UP	ASRGL1 VPS13C SHB ABCC5 PTPN18 SLC7A8 IRF2BPL	2.14e-04	198	159	7	M8730
Coexpression	GSE17580_UNINFECTED_VS_S_MANSONI_INF_TREG_UP	SPIB CDK12 PRSS12 ITGA5 GGT5 MDN1 RPL5	2.21e-04	199	159	7	M3677
Coexpression	GSE11961_FOLLICULAR_BCELL_VS_MEMORY_BCELL_DAY40_UP	GALC MLEC GMPR2 HAVCR1 OXCT1 PAN3 ADGRA3	2.27e-04	200	159	7	M9316
Coexpression	GSE10273_LOW_IL7_VS_HIGH_IL7_AND_IRF4_IN_IRF4_8_NULL_PRE_BCELL_DN	COL6A3 MAT2A TACC2 VSIG10 USP37 VPS13D OPLAH	2.27e-04	200	159	7	M322
Coexpression	GSE24142_EARLY_THYMIC_PROGENITOR_VS_DN2_THYMOCYTE_UP	RRAS ITGA9 PLXNB2 GGT5 KCNH2 AHNAK PLA2G4A	2.27e-04	200	159	7	M4545
Coexpression	GSE28726_NAIVE_CD4_TCELL_VS_NAIVE_VA24NEG_NKTCELL_UP	MAT2A GPX1 HMGCS1 RUVBL2 PGK1 CDK4 SORD	2.27e-04	200	159	7	M8308
Coexpression	GSE33425_CD161_INT_VS_NEG_CD8_TCELL_UP	SQLE UBA3 HMGCS1 SLC1A5 PGK1 USP19 AHNAK	2.27e-04	200	159	7	M8539
Coexpression	GSE17721_PAM3CSK4_VS_CPG_6H_BMDC_UP	ERCC3 TACC2 MLLT10 ECPAS RCC2 WDR6 RMC1	2.27e-04	200	159	7	M3863
Coexpression	GSE17721_PAM3CSK4_VS_CPG_4H_BMDC_UP	GNPDA1 VPS13C MAT2A TACC2 HMGCS1 FAM120A WDR6	2.27e-04	200	159	7	M3860
Coexpression	GSE8835_CD4_VS_CD8_TCELL_CLL_PATIENT_DN	TACC2 ITGA9 TMEM273 LPCAT2 DTX4 ATP6V0D2 OPLAH	2.27e-04	200	159	7	M6258
Coexpression	GSE360_DC_VS_MAC_L_MAJOR_UP	FLNA AUH MUC5B MDH2 PTPN18 GLS NXPH4	2.27e-04	200	159	7	M5181
Coexpression	HALLMARK_MTORC1_SIGNALING	SQLE HMGCS1 ME1 SLC1A5 PGK1 SDF2L1 SORD	2.27e-04	200	159	7	M5924
Coexpression	GSE37533_UNTREATED_VS_PIOGLIZATONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_DN	ASRGL1 ABCC5 PTPN18 SLC7A8 VPS13D SLC25A1 SORD	2.27e-04	200	159	7	M9002
Coexpression	GSE35685_CD34POS_CD10NEG_CD62LPOS_VS_CD34POS_CD10POS_BONE_MARROW_UP	FLNB MLEC MYCBP2 RCC2 NEDD9 WDR6 AHNAK	2.27e-04	200	159	7	M9080
Coexpression	GSE3982_MAC_VS_EFF_MEMORY_CD4_TCELL_UP	GNPDA1 SHB ME1 SLC7A8 PLA2G4C PLA2G4A ADGRA3	2.27e-04	200	159	7	M5503
Coexpression	GSE20715_0H_VS_48H_OZONE_TLR4_KO_LUNG_DN	PSMA2 SQLE HMGCS1 ITGA9 PGK1 MDN1 SDF2L1	2.27e-04	200	159	7	M4386
Coexpression	VOIGT_PBMC_FLUARIX_AGE_50_74YO_FEMALES_VS_MALES_0DY_TO_28D_UP	SPIB NIBAN3 NXPH4	2.31e-04	20	159	3	M41079
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	FLNA FLNB FLNC MLEC SQLE ABCC5 ITGA5 PLXNB2 USP19 TNRC18 SMPD3 PAN3 ADGRA3	2.75e-04	681	159	13	M5314
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL19A1 IGHV3-15 SPIB USP37 NIBAN3 IGHD GPATCH11 GMPR RBBP9	1.58e-08	177	159	9	3535575686c9700ab72700aae6f2070ebbb50044
ToppCell	severe-Myeloid-CD14_Monocytes_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	IFI27L2 RPLP2 GPX1 RRAS PLXNB2 BANF1 AHNAK RPL5 ATP5F1A	4.15e-08	198	159	9	cb8f099cf4ed320615b1c60ddab86b89d8db9a43
ToppCell	mild-Myeloid-CD16_Monocytes\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FLNA RPLP2 RRAS PTPN18 PLXNB2 SLC1A5 AHNAK SLAMF7 RPL5	4.15e-08	198	159	9	ba97ff6e9d400b53ad013dce54afd7154a0f4fc9
ToppCell	severe-Myeloid-Eosinophils\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FLNB ASRGL1 SHB TMEM273 SLC7A8 KCNH2 SMPD3 SORD	1.84e-07	170	159	8	863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCell	droplet-Marrow-nan-3m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 MYCBP2 VPS13C PPFIA4 TRPS1 RRAS PLXNB2 AHNAK	1.92e-07	171	159	8	992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-21 IGHV3-15 IGHV3-11 NOXRED1 IGHD ALDH1L2 SDF2L1 SLAMF7	2.50e-07	177	159	8	c2b0fb5921eea24d248d6e6ccb57c29b0832602c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-21 IGHV3-15 IGHV3-11 NOXRED1 IGHD ALDH1L2 SDF2L1 SLAMF7	2.50e-07	177	159	8	111fb0707ff37ca631d85bb5a09e067ffe568eb8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALC SCAF8 NRG2 GGT5 SLC7A8 TGM1 WDR6 GMPR	2.73e-07	179	159	8	2c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALC SCAF8 NRG2 GGT5 SLC7A8 TGM1 WDR6 GMPR	2.73e-07	179	159	8	6eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFI27L2 SPIB RPLP2 MYCBP2 GPX1 PTPN18 NIBAN3 SLAMF7	2.97e-07	181	159	8	d909821355f4bc9e35387cda6ecf7c56793d9da4
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFI27L2 SPIB RPLP2 MYCBP2 GPX1 PTPN18 NIBAN3 SLAMF7	2.97e-07	181	159	8	52935c496b45207a173b5ac7812f46210c3f74b0
ToppCell	cellseq2-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGHV3-21 COL19A1 IGHV3-15 SPIB NIBAN3 IGHD SDF2L1 SLAMF7	4.47e-07	191	159	8	17746a32f723c078aba1f7e320b0e3f1ab8bf5c6
ToppCell	cellseq2-Immune-Lymphocytic_B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGHV3-21 COL19A1 IGHV3-15 SPIB NIBAN3 IGHD SDF2L1 SLAMF7	4.47e-07	191	159	8	c2c450df810f83163987cd0f7ed9b50025cd3de1
ToppCell	facs-Lung-EPCAM\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA IFI27L2 GPX1 PTPN18 SLC1A5 SLAMF7 RPL5 SLC7A10	4.47e-07	191	159	8	00957dd6077e107722835084d769e84eace0611f
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD SLAMF7	5.64e-07	197	159	8	2662138671262b30508c5759038bcdcfe6551696
ToppCell	facs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA IFI27L2 TRPS1 SLC1A5 NEDD9 AHNAK SLAMF7	1.79e-06	160	159	7	1f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-CD8_low_T\|T/NK_cells / Location, Cell class and cell subclass	FLNA RPLP2 EML6 ITGA5 TMEM273 AHNAK OSR1	2.11e-06	164	159	7	92fb94492fc2b683e9d50a9db6f01d23c194b0e4
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA PPFIA4 TRPS1 GPX1 RRAS PLXNB2 AHNAK	2.19e-06	165	159	7	11227bff52eed30b80937fdb1968d0b8e6d30365
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA PPFIA4 TRPS1 GPX1 RRAS PLXNB2 AHNAK	2.19e-06	165	159	7	036f9749048e5e50769cc3210339bf4da469215d
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF8 SPIB KLRG2 SLC1A5 AHNAK SLAMF7 MBD5	3.49e-06	177	159	7	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLF8 ITGA9 ABCC6 ADH7 PLA2G4A SHE GMPR	3.49e-06	177	159	7	d68132e145bd413404fdbe215b5dbe520e756e50
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	3.62e-06	178	159	7	107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell	mild-Lymphocytic-B_cells_2\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	COL19A1 SPIB RPLP2 NIBAN3 IGHD RPL5 NXPH4	3.62e-06	178	159	7	c6fb21401ad802a57e4e4f5a1723c42779fdb33e
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IFI27L2 SPIB RPLP2 MYCBP2 PTPN18 NIBAN3 SLAMF7	3.90e-06	180	159	7	b83d067dee641941c596e4a25d81327931b6ad61
ToppCell	droplet-Limb_Muscle-nan-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA COL6A3 IFI27L2 RPLP2 SVEP1 SDF2L1 RPL5	3.90e-06	180	159	7	d3d0be136fff5d3e39ecf5a5dbefc1d0d0a6c814
ToppCell	severe-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FLNB SHB TMEM273 SLC7A8 KCNH2 SMPD3 SORD	3.90e-06	180	159	7	ac03812b1409435c55d323a7516deeac82bd3509
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-8\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL19A1 SPIB NIBAN3 GRID2IP IGHD DTX4 NXPH4	4.05e-06	181	159	7	ca34d83daca10c5fa52ecdf4eba7d31b4e7e056e
ToppCell	facs-Marrow-T-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB VPS13C PPFIA4 SLC7A8 HAVCR1 AHNAK PDZD4	4.05e-06	181	159	7	7286700396676fdc41d9723979b8b408177aceb9
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 MYCBP2 VPS13C TRPS1 NIBAN3 AHNAK SLAMF7	4.20e-06	182	159	7	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	normal_Lung-B_lymphocytes-Follicular_B_cells\|normal_Lung / Location, Cell class and cell subclass	COL19A1 SPIB RPLP2 NIBAN3 IGHD RPL5 NXPH4	4.20e-06	182	159	7	13c39228f76495deca6b948483bbde426b3e8c5b
ToppCell	Control-B_memory-0\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SPIB RPLP2 EML6 TMEM273 KCNH2 AHNAK NXPH4	4.84e-06	186	159	7	80f6f25dbe3c5efe4bc350f5d2eb990c38aab338
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERN2 RCC2 OXCT1 LPCAT2 SMPD3 CDK4 SORD	5.19e-06	188	159	7	bfd3b4f57785596b2bd2c657e0d2d8b0f40ba36d
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA COL6A3 MYCBP2 MAP4 ITGA9 NIBAN3 AHNAK	5.57e-06	190	159	7	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA IFI27L2 SLC1A5 SVEP1 OSR1 SDF2L1 SLC7A10	6.17e-06	193	159	7	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-21 IGHV3-15 SPIB NIBAN3 IGHD SMPD3 SLAMF7	6.17e-06	193	159	7	325859399411d0e66a78a385dffa886df9af3198
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-basal_cell\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 RPLP2 ADH7 SDF2L1 RPL5 ATP5F1A CDK4	6.17e-06	193	159	7	13282e849b11f48085f0840d112a06e896b32cd7
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 RPLP2 PGK1 ADH7 SDF2L1 RPL5 ATP5F1A	6.17e-06	193	159	7	63205026e20cf2c7bfb7d08bba48d5df7976ccca
ToppCell	droplet-Tongue-TONGUE\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 MAT2A HMGCS1 WNK1 SLC7A8 GRID2IP SORD	6.82e-06	196	159	7	44a30b1a5f3d8c845e5f3bd17d8102a7449f555b
ToppCell	droplet-Tongue-TONGUE-1m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 MAT2A HMGCS1 WNK1 SLC7A8 GRID2IP SORD	6.82e-06	196	159	7	9935bdb10789e8cfc922dca526ca3bf8317fe270
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 MAT2A HMGCS1 WNK1 SLC7A8 GRID2IP SORD	6.82e-06	196	159	7	a85f5f1e6acc798e9e02b1a21e0ffe87a323c333
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	6.82e-06	196	159	7	e9fe5090452ffdde4bb81b62d57037d823281d00
ToppCell	COVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast\|COVID_vent / Disease condition, Lineage, Cell class and subclass	IGHV3-21 IGHV3-15 MLEC IGHV3-11 ALDH1L2 SDF2L1 SLAMF7	6.82e-06	196	159	7	026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-GMP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RPLP2 RUVBL2 PM20D2 SDF2L1 RPL5 ATP5F1A CDK4	6.82e-06	196	159	7	3cf73b33330b9fca5c8abf03f2f0d8244245b522
ToppCell	Biopsy_Other_PF-Immune-B_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	6.82e-06	196	159	7	123cd893fd1ae315a655e909c08528f82e9013ff
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	7.05e-06	197	159	7	88b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_cell\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	7.05e-06	197	159	7	76465bb2408c7c75f694e8f7cf1a606b796afc3a
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	7.05e-06	197	159	7	9fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCell	COVID_vent-Lymphocytic-Plasma_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	IGHV3-21 MLEC IGHV3-11 ALDH1L2 SDF2L1 SLAMF7 ATP5F1A	7.29e-06	198	159	7	e84c5f712e1dea548d0e2aba6625598f9671d3a0
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLNB ASRGL1 MYCBP2 ERN2 SLC1A5 DTX4 SORD	7.53e-06	199	159	7	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGHV3-21 COL19A1 IGHV3-15 SPIB IGHV3-11 NIBAN3 IGHD	7.53e-06	199	159	7	8e02d3a066e79e0f2024a10738e0ea070513ef19
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB ASRGL1 MYCBP2 ERN2 SLC1A5 DTX4 SORD	7.53e-06	199	159	7	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLNB ADCY4 ASRGL1 ITGA5 NEDD9 SHE NOVA2	7.78e-06	200	159	7	c55efd997392e99068b673542f56f1a209c5a6c8
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Bronchial_vessel\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FLNB ADCY4 ASRGL1 ITGA5 NEDD9 SHE NOVA2	7.78e-06	200	159	7	a18817d36b2b30a32e1513d36174bf98dfea2a92
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FLNB ADCY4 ASRGL1 ITGA5 NEDD9 SHE NOVA2	7.78e-06	200	159	7	71979bbcc035d5b8882f1502b5a8ef248aaba45a
ToppCell	mild_COVID-19-B_cell\|mild_COVID-19 / disease group, cell group and cell class (v2)	KLF8 PRR36 NIBAN3 IGHD DTX4 MYO18B	8.04e-06	132	159	6	4b372483bc106aecc7b96a09131e1695e54e7dc4
ToppCell	Control-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA FLNB SPIB PTPN18 AHNAK SMPD3	1.54e-05	148	159	6	662c057030effc9eb61216e81d3967e6983c244f
ToppCell	3'_v3-Lung-Lymphocytic_B-Naive_B_cells\|Lung / Manually curated celltypes from each tissue	IGHV3-21 COL19A1 SPIB NIBAN3 IGHD CNGB3	1.93e-05	154	159	6	2b7d7f09c75bbc22de1358fc44b8ad5d3f656617
ToppCell	facs-Heart-RA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA4 GPX1 PTPN18 TMEM273 LPCAT2 SLAMF7	2.95e-05	166	159	6	e868e90b5272da6ccfc1c371e1b1aac1d63c5139
ToppCell	facs-Heart-RA-24m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA4 GPX1 PTPN18 TMEM273 LPCAT2 SLAMF7	2.95e-05	166	159	6	af30d3fa9380056be17b0dc720c8be09418b5529
ToppCell	facs-Heart-RA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPFIA4 GPX1 PTPN18 TMEM273 LPCAT2 SLAMF7	2.95e-05	166	159	6	fb3daa5e5a6d9ecf52ef2e019258e84761e87b65
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-9\|TCGA-Brain / Sample_Type by Project: Shred V9	MAP4 VPS13D GK2 AHNAK SLC25A48 SORD	3.05e-05	167	159	6	013971700e80b71e4b8c79b8fff0d8beeac295c3
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGCS1 ME1 TGM1 GLS GMPR SORD	3.15e-05	168	159	6	624cf8f439c0a3c877927e085ec260ca79896b5a
ToppCell	droplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF8 SPIB PPFIA4 NIBAN3 HAVCR1 PDZD4	3.15e-05	168	159	6	e8878ec68b21c8d5694d7209b816d2f869673164
ToppCell	droplet-Liver-LIVER-NPC-1m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF8 SPIB PPFIA4 NIBAN3 HAVCR1 PDZD4	3.15e-05	168	159	6	a007758c219d3d5db2b5529f29af63be0d408304
ToppCell	PND14-Immune-Immune_Myeloid-DC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPLP2 PPFIA4 GPX1 PTPN18 AHNAK SLAMF7	3.48e-05	171	159	6	8772d6349db24de47f089df2032a80345db7177f
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-21 COL19A1 SPIB IGHV3-11 NIBAN3 IGHD	3.60e-05	172	159	6	172e3c78f8e97988a4fd8624514e731282ddc16d
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-21 COL19A1 SPIB IGHV3-11 NIBAN3 IGHD	3.60e-05	172	159	6	5fb0ea6145892a258696197b3feed9760187e712
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-21 COL19A1 SPIB IGHV3-11 NIBAN3 IGHD	3.60e-05	172	159	6	2214cc37d7c21b868768d3f74ca4631d339d37b3
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGHV3-21 COL19A1 SPIB IGHV3-11 NIBAN3 IGHD	3.60e-05	172	159	6	07620728a6cdeea805e1365e588be096c17a370c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA FLNC SPEG RRAS KCNH2 NXPH4	3.72e-05	173	159	6	3001dd39244ef0a5a475d569a78f4ae427a55db6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLNA FLNC SPEG RRAS KCNH2 NXPH4	3.72e-05	173	159	6	c88883fb2a33e21d4201aa393674aa3f2ad780c9
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IFI27L2 TRPS1 GPX1 PTPN18 FAM120A AHNAK	3.84e-05	174	159	6	02ab165b064acb91f2d3f59cc5be195899d61a83
ToppCell	droplet-Marrow-BM-30m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 PPFIA4 TRPS1 RRAS PLXNB2 AHNAK	3.84e-05	174	159	6	118ba2729ecc6aa1bb8548f3cf537b3f9e902ef0
ToppCell	CTRL-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	FLNB NIBAN3 PLA2G4A SMPD3 SLAMF7 ADGRA3	3.84e-05	174	159	6	ff4315e9fad198cc323fc987deb8652da137cf98
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-CD5+_CCL22+_mature_B\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IGHV3-21 COL19A1 SPIB NIBAN3 IGHD SLAMF7	3.96e-05	175	159	6	fa53ea81ad943a2cd266114829135cbcbcf2f634
ToppCell	droplet-Marrow-nan-24m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 PPFIA4 TRPS1 RRAS PLXNB2 AHNAK	4.09e-05	176	159	6	eddac2ba68d234e3f56f4ca0e11c19bc0e95b6e1
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF8 PPFIA4 RUVBL2 OXCT1 MDN1 SLAMF7	4.09e-05	176	159	6	6b4afd2c9268172063fe5832896bea15e862579e
ToppCell	Control-Lymphoid-pDC\|Control / Condition, Lineage and Cell class	FLNB SPIB NIBAN3 SMPD3 SLAMF7 ADGRA3	4.09e-05	176	159	6	5de16ff65476bde8b23322a44e11412e14f1bafe
ToppCell	Control-B_cells\|Control / group, cell type (main and fine annotations)	COL19A1 EML6 NIBAN3 IGHD ALDH1L2 SLAMF7	4.09e-05	176	159	6	9125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ECPAS TMEM273 AHNAK SLAMF7 ATP5F1A PDZD4	4.22e-05	177	159	6	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ECPAS TMEM273 AHNAK SLAMF7 ATP5F1A PDZD4	4.22e-05	177	159	6	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	ECPAS TMEM273 AHNAK SLAMF7 ATP5F1A PDZD4	4.22e-05	177	159	6	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ECPAS TMEM273 AHNAK SLAMF7 ATP5F1A PDZD4	4.22e-05	177	159	6	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ECPAS TMEM273 AHNAK SLAMF7 ATP5F1A PDZD4	4.22e-05	177	159	6	d5aeda113afaa2425874394610344570c9078478
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNA SLC1A5 AHNAK SLAMF7 NXPH4 PDZD4	4.22e-05	177	159	6	84930899eb2978598bc8a351cbcd9e714e46799d
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	TACC2 SMPD3 SLAMF7 DNAH9 ADGRA3 OPLAH	4.50e-05	179	159	6	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLNB ASRGL1 ITGA5 ITGA9 SHE NOVA2	4.50e-05	179	159	6	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_straight_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPX1 ME1 SLC7A8 OXCT1 ATP5F1A SORD	4.64e-05	180	159	6	b34d933cdabf692f02eaaf65c2aaca1fb9510627
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGHV3-21 COL19A1 SPIB NIBAN3 IGHD SLAMF7	4.64e-05	180	159	6	cd04d7bf92986a5b8a0193c9b92ec47da3929bac
ToppCell	cellseq-Immune-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGHV3-21 COL19A1 SPIB NIBAN3 IGHD SLAMF7	4.64e-05	180	159	6	663a800ab70e7ab7d13183417f9c1ed36907aa5e
ToppCell	moderate-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB SPIB CDHR5 NIBAN3 MDN1 SMPD3	4.64e-05	180	159	6	1d8df7df03a71f49d6683554d3c948ce90dda42e
ToppCell	Healthy-B_memory\|Healthy / disease group, cell group and cell class	KLF8 COL19A1 SPIB EML6 NIBAN3 NXPH4	4.78e-05	181	159	6	7b903076efb90026b9845af0c7a840901451193a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL19A1 SPIB MYCBP2 NIBAN3 IGHD SLAMF7	4.93e-05	182	159	6	5f1f10c845b73d1f69794277925ef847ff23ac2d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL19A1 CDHR5 ABCC6 SLC7A8 SLC25A48 SORD	5.08e-05	183	159	6	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	3'_v3-blood-Lymphocytic_B-Memory_B_cells\|blood / Manually curated celltypes from each tissue	COL19A1 SPIB EML6 NIBAN3 IGHD NXPH4	5.08e-05	183	159	6	e3a418b745d7f040adf47be9e1043b945cae47ed
ToppCell	COVID-19_Severe-gd_T\|COVID-19_Severe / Disease condition and Cell class	FLNA TMEM273 AHNAK SLAMF7 ATP5F1A PDZD4	5.24e-05	184	159	6	791f1bcb954aadc63d4117c400537d036f68734d
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL19A1 SPIB MYCBP2 NIBAN3 IGHD GLS	5.40e-05	185	159	6	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-21 IGHV3-15 IGHV3-11 ALDH1L2 SDF2L1 SLAMF7	5.40e-05	185	159	6	0fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGHV3-21 IGHV3-15 IGHV3-11 ALDH1L2 SDF2L1 SLAMF7	5.40e-05	185	159	6	79edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFI27L2 MYCBP2 VPS13C TRPS1 AHNAK SLAMF7	5.40e-05	185	159	6	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
Drug	hydroxyl radicals	COL6A3 GALC GNPDA1 ASRGL1 AUH MYCBP2 PPM1D MAT1A SQLE HMGCS1 MDH2 USP37 PTPN18 GGT5 ADH7 TGM1 PCYOX1L PLA2G4C ALDH1L2 SLC25A1 GNPDA2 GLS TGDS PLA2G4A ATP6V0D2 SMPD3 NXPH4 ATP5F1A OPLAH	3.15e-08	1341	156	29	CID000000961
Drug	AC1Q68Z5	METTL3 GNPDA1 ERCC3 AUH MAT2A HMGCS1 GMPR2 MDH2 ME1 OXCT1 LPCAT2 GNPDA2 GLS VPS13A GMPR	7.21e-08	386	156	15	CID000000181
Drug	phosphoenolpyruvate	ADCY4 GNPDA1 MDH2 ME1 PGK1 SLC25A1 GNPDA2 GLS OPLAH SORD	1.96e-06	210	156	10	CID000001005
Drug	monochlorobimane	ABCC5 GMPR2 ABCC6 GMPR YME1L1	3.36e-06	34	156	5	CID000114886
Drug	AC1O3LUB	ASRGL1 NRG2 SLC1A5 GGT5 GLS GMPR	6.08e-06	66	156	6	CID006331868
Drug	salsalate	RPLP2 GMPR2 SLC25A1 GMPR DNAH9 RPL5	6.08e-06	66	156	6	CID000005161
Drug	Zorubicin HCl	ASRGL1 ABCC6 SMPD3	6.22e-06	6	156	3	CID000037465
Drug	3,4,5,3',4'-pentachlorobiphenyl	FLNB ADCY4 GNPDA1 PRSS12 SQLE ABCC5 HMGCS1 ME1 SLC1A5 PGK1 BANF1 ABCC6 ADH7 SLC7A8 KCNH2 AHNAK PLA2G4A GMPR SMPD3 RPL5 NXPH4 RBBP9 OPLAH	9.77e-06	1219	156	23	ctd:C023035
Drug	acivicin	ASRGL1 SLC1A5 GGT5 GLS OPLAH SORD	1.38e-05	76	156	6	CID000002007
Drug	malonate	MAP4 MAT1A MAT2A MDH2 ME1 SLC1A5 OXCT1 KCNH2 SDF2L1	1.45e-05	209	156	9	CID000000867
Drug	acetate	FLNB GNPDA1 MAT2A MDH2 ME1 PGK1 ADH7 HAVCR1 OXCT1 LPCAT2 GNPDA2 DNAH9 ATP5F1A RBBP9 SORD	1.66e-05	599	156	15	CID000000175
Drug	D-glucosamine-6P	GNPDA1 ASRGL1 GNPDA2	1.72e-05	8	156	3	CID000121988
Drug	thiazole-4-carboxamide adenine dinucleotide	MDH2 ABCC6 GMPR SLAMF7	2.40e-05	25	156	4	CID000073680
Drug	thapsigargin; Down 200; 0.1uM; PC3; HT_HG-U133A	COL6A3 METTL3 NRG2 ABCC5 MUC5B VSIG10 ITGA5 SBNO1	3.37e-05	179	156	8	7103_DN
Drug	glutamate	ADCY4 AUH MAP4 MAT2A NRG2 MDH2 ME1 SLC1A5 PGK1 GGT5 SLC7A8 OXCT1 MDN1 GLS LRCH4 SLC17A8 YME1L1 OPLAH SORD	3.37e-05	962	156	19	CID000000611
Drug	Cephaeline dihydrochloride heptahydrate [6487-30-5]; Down 200; 6uM; MCF7; HT_HG-U133A	GNPDA1 MLEC MAP4 ERN2 VPS13D KCNH2 ANGEL2 GMPR	3.50e-05	180	156	8	3290_DN
Drug	2-butenedioate	ERCC3 ASRGL1 MDH2 ME1 SLC1A5 GGT5 OXCT1 GLS NOVA2	3.53e-05	234	156	9	CID000000723
Drug	AC1ODU4J	ASRGL1 MAT1A MAT2A	3.66e-05	10	156	3	CID000151277
Drug	verbenone	MDH2 ADH7 YME1L1	3.66e-05	10	156	3	CID000029025
Drug	4HADNT	GMPR2 TGM1 GMPR	3.66e-05	10	156	3	CID005375469
Drug	3-nitrofluoranthen-6-ol	GMPR2 GMPR	4.66e-05	2	156	2	CID000146572
Drug	3-nitrofluoranthen-9-ol	GMPR2 GMPR	4.66e-05	2	156	2	CID000146573
Drug	3-nitrofluoranthen-8-ol	GMPR2 GMPR	4.66e-05	2	156	2	CID000146567
Drug	1,3,6-trinitropyrene	GMPR2 GMPR	4.66e-05	2	156	2	CID000053229
Drug	AC1L25J4	GMPR2 GMPR	4.66e-05	2	156	2	CID000041328
Drug	2-methylcarbazole	GMPR2 GMPR	4.66e-05	2	156	2	CID000019290
Drug	m-nitrobenzamidine hydrochloride	GMPR2 GMPR	4.66e-05	2	156	2	CID000165122
Drug	2-nitrobenzofuran	GMPR2 GMPR	4.66e-05	2	156	2	CID000036328
Drug	1,3,6,8-tetranitropyrene	GMPR2 GMPR	4.66e-05	2	156	2	CID000034321
Drug	2-amino-4-methylthio-3-butenoic acid	MAT1A MAT2A	4.66e-05	2	156	2	ctd:C083253
Drug	AC1L1IZ2	ADCY4 MAT1A MAT2A MDH2 WNK1 PGK1 MYO18B DNAH9 YME1L1 ATP5F1A	4.89e-05	304	156	10	CID000004795
Drug	ammonia	GNPDA1 ASRGL1 MAT1A MAT2A GMPR2 MDH2 ME1 BANF1 TGM1 GNPDA2 GLS GMPR SLAMF7	5.09e-05	509	156	13	CID000000222
Drug	Vancomycin	FLNA COL6A3 AUH PRSS12 SQLE TACC2 RRAS WNK1 PTPN18 RCC2 SLC7A8 HAVCR1 TGM1 OXCT1 AHNAK DTX4 PLA2G4A SORD	5.10e-05	906	156	18	ctd:D014640
Drug	Trimethobenzamide hydrochloride [554-92-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	PRR36 MAP4 ERN2 AHDC1 AARSD1 SLC7A8 KCNH2 GMPR	6.17e-05	195	156	8	4180_DN
Drug	Methiazole; Down 200; 15uM; PC3; HT_HG-U133A	MAP4 NRG2 ERN2 PTPN18 AHDC1 USP19 NXPH4 RBBP9	6.63e-05	197	156	8	4532_DN
Drug	Crotamiton [483-63-6]; Up 200; 19.6uM; MCF7; HT_HG-U133A	SPIB PRR36 MAP4 CAST MUC5B ECPAS ERN2 GK2	6.63e-05	197	156	8	3388_UP
Drug	AC1L1I1P	MAT1A MAT2A CAST MDH2 RBBP9	6.69e-05	62	156	5	CID000004385
Drug	Trifluridine [70-00-8]; Up 200; 13.6uM; HL60; HT_HG-U133A	PRSS12 SHB ERN2 SLC7A8 AHNAK CNGB3 SLAMF7 NXPH4	7.11e-05	199	156	8	6136_UP
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HG-U133A	MYCBP2 MAP4 SHB CAST ECPAS WNK1 GLS FUBP3	7.11e-05	199	156	8	122_DN
Drug	Zearalenone	ERCC3 ASRGL1 SQLE GPX1 ABCC5 MUC5B HMGCS1 MDH2 SLC1A5 PGK1 ADH7	8.02e-05	389	156	11	ctd:D015025
Drug	dioscin	ABCC6 YME1L1 PDZD4	8.58e-05	13	156	3	CID000119245
Drug	alanine	ASRGL1 MDH2 WNK1 SLC1A5 SLC7A8 TGM1 GLS IRF2BPL SLC7A10	1.03e-04	269	156	9	CID000000602
Drug	ronidazole	GMPR2 ABCC6 GMPR	1.09e-04	14	156	3	CID000005094
Drug	ANIT	ABCC5 ABCC6 GGT5 HAVCR1 SORD	1.12e-04	69	156	5	CID000011080
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNA FLNB FLNC	1.39e-07	3	154	3	DOID:0080096 (implicated_via_orthology)
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13C VPS13D VPS13A	1.39e-07	3	154	3	DOID:0111611 (implicated_via_orthology)
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNA FLNB FLNC	1.39e-07	3	154	3	DOID:0111190 (implicated_via_orthology)
Disease	Parkinson's disease 23 (implicated_via_orthology)	VPS13C VPS13A	2.71e-05	2	154	2	DOID:0060896 (implicated_via_orthology)
Disease	choreaacanthocytosis (implicated_via_orthology)	VPS13C VPS13A	2.71e-05	2	154	2	DOID:0050766 (implicated_via_orthology)
Disease	Cohen syndrome (implicated_via_orthology)	VPS13C VPS13A	8.09e-05	3	154	2	DOID:0111590 (implicated_via_orthology)
Disease	osteochondrodysplasia (is_implicated_in)	FLNA FLNB TRPS1	1.27e-04	19	154	3	DOID:2256 (is_implicated_in)
Disease	Medullary Neoplasms	PPM1D CDK4	1.61e-04	4	154	2	C0751887
Disease	Brain Stem Neoplasms, Primary	PPM1D CDK4	1.61e-04	4	154	2	C0751886
Disease	Pontine Tumors	PPM1D CDK4	1.61e-04	4	154	2	C0751889
Disease	Mesencephalic Neoplasms	PPM1D CDK4	1.61e-04	4	154	2	C0751888
Disease	Brain Stem Neoplasms	PPM1D CDK4	1.61e-04	4	154	2	C0677866
Disease	chronic obstructive pulmonary disease, CC16 measurement	ASRGL1 AHNAK	4.00e-04	6	154	2	EFO_0000341, EFO_0005080
Disease	reticulocyte measurement	FLNA FLNB AUH TRPS1 EML6 GPX1 USP37 ECPAS PLXNB2 AHNAK GLS VPS13A GMPR ADGRD2 SLC7A10	4.25e-04	1053	154	15	EFO_0010700
Disease	Malignant neoplasm of breast	FLNA FLNB ERCC3 COL19A1 RPLP2 PPM1D GPX1 TACC2 ITGA9 WNK1 SBNO1 PLA2G4A DNAH9 PLXNB1 PDZD4	5.22e-04	1074	154	15	C0006142
Disease	level of oxylipin in blood plasma	ITGA9 LPCAT2	5.59e-04	7	154	2	OBA_2050338
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13C VPS13A	7.42e-04	8	154	2	DOID:0050753 (implicated_via_orthology)
Disease	atrial fibrillation	PPFIA4 CHGA TMEM273 KCNH2 SDF2L1 ADGRD2 MYO18B MBD5	7.69e-04	371	154	8	EFO_0000275
Disease	pseudoxanthoma elasticum (is_implicated_in)	GPX1 ABCC6	9.51e-04	9	154	2	DOID:2738 (is_implicated_in)
Disease	uveitis	CAST TNRC18	9.51e-04	9	154	2	EFO_1001231
Disease	Paroxysmal atrial fibrillation	PPFIA4 KCNH2 IRF2BPL MYO18B MBD5	1.39e-03	156	154	5	C0235480
Disease	familial atrial fibrillation	PPFIA4 KCNH2 IRF2BPL MYO18B MBD5	1.39e-03	156	154	5	C3468561
Disease	Persistent atrial fibrillation	PPFIA4 KCNH2 IRF2BPL MYO18B MBD5	1.39e-03	156	154	5	C2585653
Disease	Parkinson's disease (implicated_via_orthology)	VPS13C PGK1 ADH7 VPS13A SLC17A8	1.43e-03	157	154	5	DOID:14330 (implicated_via_orthology)
Disease	Atrial Fibrillation	PPFIA4 KCNH2 IRF2BPL MYO18B MBD5	1.56e-03	160	154	5	C0004238
Disease	myopathy (implicated_via_orthology)	FLNA FLNB FLNC	2.03e-03	48	154	3	DOID:423 (implicated_via_orthology)
Disease	hypothyroidism (implicated_via_orthology)	GPX1 DUOX1	2.03e-03	13	154	2	DOID:1459 (implicated_via_orthology)
Disease	tumor necrosis factor ligand superfamily member 11 measurement	IGHV3-21 IGHV3-11	2.03e-03	13	154	2	EFO_0010617
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	MLLT10 TLX1 RPL5	2.70e-03	53	154	3	C1961099
Disease	hepcidin:transferrin saturation ratio	EML6 PAN3	2.72e-03	15	154	2	EFO_0007902
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A	2.72e-03	15	154	2	DOID:3146 (implicated_via_orthology)
Disease	iritis	CAST TNRC18	3.50e-03	17	154	2	EFO_1000997
Disease	myeloid white cell count	FLNB GNPDA1 EML6 ABCC5 CHGA GGT5 HAVCR1 SLC25A1 ADGRD2 ATP6V0D2 RMC1 PLXNB1	3.83e-03	937	154	12	EFO_0007988
Disease	Post-Traumatic Osteoporosis	PSMA2 GPX1 OXCT1	4.02e-03	61	154	3	C0751406
Disease	Osteoporosis, Senile	PSMA2 GPX1 OXCT1	4.02e-03	61	154	3	C0029459
Disease	Osteoporosis, Age-Related	PSMA2 GPX1 OXCT1	4.02e-03	61	154	3	C0001787
Disease	serum albumin measurement	MAP4 CDK12 TRPS1 MLLT10 SVEP1 ADH7 SBNO1 IRF2BPL EIF3J	4.02e-03	592	154	9	EFO_0004535
Disease	sensorineural hearing loss (implicated_via_orthology)	SLC7A8 DNAH9	4.37e-03	19	154	2	DOID:10003 (implicated_via_orthology)
Disease	Osteoporosis	PSMA2 GPX1 OXCT1	4.40e-03	63	154	3	C0029456

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVQKRGAPAGAGSGT	PTPN18	356	Q99952
VKPGSTCVVFGLGGV	ADH7	201	P40394
VGAAGIPAGGVLTLA	SLC1A5	426	Q15758
KAEAAEGRAPGGGLI	AMER2	211	Q8N7J2
PGKVESGAGDAIGLA	CDK12	1091	Q9NYV4
SIGGTSGPHVGKKVI	NEDD9	141	Q14511
GNIIGSGIFISPKGV	SLC7A10	51	Q9NS82
VVHGGGAGPISKDRK	ASRGL1	6	Q7L266
GGGIPIIVCGITAAA	ADGRA3	881	Q8IWK6
KGVINIIPGSGGIAG	ALDH1L2	641	Q3SY69
GGEPVSLGSLRGKVL	GPX1	26	P07203
GPRVAEVLEGKGAGK	AARSD1	366	Q9BTE6
GGDGVKVPGIDATTK	AHNAK	5341	Q09666
IKGGADVSGGVSAPD	AHNAK	5566	Q09666
AGGVPGRVHITGATL	ADCY4	401	Q8NFM4
AVAAAGVGGPGLTEL	AHDC1	706	Q5TGY3
AGHPGAEVALVGGLK	ANGEL2	491	Q5VTE6
GTVARGAGAGVVVKD	CDHR5	361	Q9HBB8
TLGHKVLVCGAGPIG	SORD	171	Q00796
AGPRAGGSVVLGQVD	DTX4	36	Q9Y2E6
VFGGIGDPVTCLKSG	DEFB4A	21	O15263
VDALGNAIDGKGPIG	ATP5F1A	151	P25705
SGDVPGARGAVEGIL	AIRE	196	O43918
TGGVGAVALLIGPNA	HMGCS1	171	Q01581
LGGALGVPGAKESRA	NXPH4	216	O95158
LQEGTFKAVARGPGG	MUC5B	966	Q9HC84
RPATAGKAGGAAVVI	RCC2	71	Q9P258
VAVGAGGAPAGPAVI	RBM42	266	Q9BTD8
VGLPAKSGVAGGILL	GLS	476	O94925
AVVVGKGRGAPGDDS	NIBAN3	16	Q86XR2
LAPRVGGTGGAVSEL	PCDHA6	566	Q9UN73
GNIIGSGIFVSPKGV	SLC7A8	51	Q9UHI5
PGLRAVVGGAAAVST	LRCH4	436	O75427
VGGGIGVTPFASILK	DUOX1	1386	Q9NRD9
KAVIVPGNGGGDVTT	RBBP9	6	O75884
GEKVAGLQGLGSPAL	DDI1	131	Q8WTU0
PLTDGVIRLAGGKGS	PRSS12	381	P56730
LEPRVGGTGGAASKL	PCDHA8	566	Q9Y5H6
GGTGGAASKLVPRSV	PCDHA8	571	Q9Y5H6
LEGSPGVGKTSLVGA	MDN1	1751	Q9NU22
GGGKAAVVLLAVGGQ	GPR61	281	Q9BZJ8
VQLVESGGGLVKPGG	IGHV3-11	21	P01762
GGALAVGAVPVVLSA	IFI27L2	11	Q9H2X8
IKPTALIGVAAIGGA	ME1	371	P48163
NVGHLPAGGAVKTEG	MAP4	1076	P27816
KAAGGIELFVGGIGP	GNPDA1	126	P46926
VQLVESGGGLVKPGG	IGHV3-15	21	A0A0B4J1V0
GLVETKLAIIPGGGG	AUH	206	Q13825
VEDPVRKVGGGGTAG	EIF3J	21	O75822
IRGPGLGVAGVAGAA	MLEC	26	Q14165
VDQLKGRGGPFVDGV	PPFIA4	491	O75335
KVAVLGASGGIGQPL	MDH2	26	P40926
VIGGPQGDAGLTGRK	MAT2A	251	P31153
NPKDVLGRGAGGTFV	ERN2	521	Q76MJ5
GGAGAPGAVVVDVDL	KCNH2	186	Q12809
TVVFQGGALGKTPDG	ECPAS	1046	Q5VYK3
GGLGLTVEGPCEAKI	FLNB	1071	O75369
VVASGPGLEHGKVGE	FLNB	1136	O75369
AGAGGLSIAVEGPSK	FLNB	2221	O75369
AEVGVGAGGKRPGSV	IRF2BPL	321	Q9H1B7
PGKIAVVGAGIGGSA	PCYOX1L	26	Q8NBM8
AVGPGAGEAQGVPVK	PLXNB1	1756	O43157
GGVEVDVFGKLGRSP	PLXNB2	871	O15031
VLFSAVAVGKPRAGG	PGAM5	21	Q96HS1
LSLAGGPRVGGVAAA	PDZD4	601	Q76G19
VEGKVQGLVPAGGSS	NRG2	131	O14511
KAEGPGLNRTGVEVG	FLNC	871	Q14315
IDEKVGGTNLGAPGA	FUBP3	421	Q96I24
ITVPLIGGDGKNAGS	KLF8	201	O95600
VIGGPQGDAGVTGRK	MAT1A	251	Q00266
SGADIIKVGIGPGSV	GMPR2	171	Q9P2T1
PSQGGKLEIAGTVVG	FAM120A	941	Q9NZB2
GGASLELLEGKVLPG	PGK1	396	P00558
GEVSGKGPAVAAREA	PPM1D	61	O15297
QGGDGVARAVPGSIK	SMPD3	191	Q9NY59
IVPNSTAGLIIGKGG	NOVA2	136	Q9UNW9
AQGIGKLASVPAGGA	RPLP2	56	P05387
VQLVESGGGLVKPGG	IGHV3-21	21	A0A0B4J1V1
AEKKGPGEVAGTVTG	METTL3	161	Q86U44
GSPAGGLGALLDVTK	OSR1	141	Q8TAX0
AATVPGAGVGNVGLR	LPCAT2	11	Q7L5N7
PGNTGKLFVGVGISR	PRDM9	506	Q9NQV7
LAAAVAVVAPPGVGG	PAN3	21	Q58A45
TIDVVGGAPQDKGIG	ITGA9	261	Q13797
AEFTKTGRVVLGGPG	ITGA5	211	P08648
TPGGKIVGTLCAIAG	KCNA10	431	Q16322
AAVGSLLAGGPVVAI	ABCC5	291	O15440
APVVAVLGSGGGLRA	PLA2G4C	41	Q9UP65
LGPNVSIGKGVTVGE	GMPPA	301	Q96IJ6
LKGSLGTGAEEGAPV	GBX1	236	Q14549
LGGSGPCFVLEVAKG	GRID2IP	21	A4D2P6
GQALGKSGGGIVEPI	GPATCH11	111	Q8N954
VDVRVKPVGAAGGSS	KLRG2	126	A4D1S0
GLIKTGALEGVPISG	GK2	241	Q14410
GGRGPIFELKSVAAG	AVEN	236	Q9NQS1
FVALKSVRVPNGGGG	CDK4	31	P11802
KGDRGEPGVIGSQGV	COL19A1	491	Q14993
AGAGGLAIAVEGPSK	FLNA	2266	P21333
KRGGAVPIGIGIGNA	COL6A3	1156	P12111
PGVGGKRDVVFLIDG	COL6A3	1226	P12111
KLGGECVAGPVGLLS	SQLE	496	Q14534
VAGKVPTGGVEEGLL	IGHD	206	P01880
GEKRGGAEGSPKLAV	CCDC144B	6	Q3MJ40
QGSKLVIGGAGGELI	GGT5	481	P36269
GESVAGITAISGKPG	CAST	111	P20810
KEAGGIDLFVGGIGP	GNPDA2	126	Q8TDQ7
VKDGLVVGGPGDASV	MBD5	1071	Q9P267
VTGGKERPTKEGGAV	EML6	1611	Q6ZMW3
GLEVGPESGLAGAKA	DNAH9	86	Q9NYC9
GVIVLPCGAGKSLVG	ERCC3	336	P19447
SGADIIKVGVGPGSV	GMPR	171	P36959
GEKPVGSLAGIGEVL	BANF1	16	O75531
EALTKAEGRGGLPAG	CROCCP3	171	Q8IVE0
PDTGGVFIAGRVNKG	GALC	571	P54803
TVKDVGFGSLVIPGG	SCAF8	726	Q9UPN6
SGAGGGVAAAAVPLI	SALL3	191	Q9BXA9
DGAGVGKGRTIAGII	SBNO1	321	A3KN83
GTVKRPVLEGQGGFE	PRRT3	216	Q5FWE3
DVPVVAILGSGGGFR	PLA2G4A	186	P47712
SATPEEFKVGIIGGG	NOXRED1	71	Q6NXP6
GKIAGRAVLIAGQPG	RUVBL2	66	Q9Y230
IKVESAAGGGAGDPL	SHB	186	Q15464
GCLLAVVGPVGAGKS	ABCC6	656	O95255
VLHRGEAGTGTPVKG	OPLAH	141	O14841
KPLAERAGGIGGATI	PRR36	56	Q9H6K5
DSVAGSVKVGGEAGP	HAVCR1	16	Q96D42
GALKGAVDGGLSIPH	RPL5	161	P46777
VPDGSVAAAGLGLGL	MYCBP2	41	O75592
MVAGVVSVGLGGPVD	SLC25A48	111	Q6ZT89
KDIPDGATVLVGGFG	OXCT1	51	P55809
ALVAGPEGKGSEAGT	SPIB	151	Q01892
KLSDGGAGLSVGLPI	SVEP1	1531	Q4LDE5
VVVLGTPAEEDGGGK	PM20D2	156	Q8IYS1
VAPVAAGEVVKTAGG	ADGRD2	41	Q7Z7M1
AVSAVGGIIGALPGN	MLLT10	891	P55197
VVPQGLFRGGKSGEL	CHGA	311	P10645
HGEVQVLGGPDGTKV	CNGB3	566	Q9NQW8
GLPGGFAKRVLVTGG	TGDS	11	O95455
GGAGDVGLPALVAEA	TNRC18	286	O15417
VGLPALVAEAGRGGA	TNRC18	291	O15417
GGTEGFKGNARVILP	UBA3	201	Q8TBC4
AVETKGFLQGAPAGG	TRPS1	846	Q9UHF7
GGLEAPAARVGGAKV	USP19	381	O94966
LKALVGGAVGGLAGA	VPS13A	2906	Q96RL7
RAKVGAGGGAPVAVA	SPEG	26	Q15772
LLVPGGGAAKTGAEL	SDF2L1	21	Q9HCN8
GGATGVVVKGPDDRN	RMC1	41	Q96DM3
GKAILAGGLAGGIEI	SLC25A1	26	P53007
LAAVAGGAPSVGIKA	PSMA2	26	P25787
GGAPSVGIKAANGVV	PSMA2	31	P25787
GKGLVGAVARPTGGI	VPS13C	3556	Q709C8
LGALATPGEKAGAGR	TACC2	1421	O95359
AASGPVKELVGSVGG	SLAMF7	21	Q9NQ25
GGKARAGAGAPVVGS	WDR6	531	Q9NNW5
GAKSPLEIEGAAGGL	MYO18B	2306	Q8IUG5
PGTGKTLLARAVAGE	YME1L1	381	Q96TA2
GGAGALSAAGVIRVP	TLX1	121	P31314
PGRGSIKTVAGSGIA	USP37	166	Q86T82
EPGGVIVGKSKLGVE	VSIG10	261	Q8N0Z9
GKGTHVIIPVGKGGS	TGM1	176	P22735
FITGPTGSVKIGDLG	WNK1	356	Q9H4A3
PSETHKLVVVGGGGV	RRAS	26	P10301
AAELGSGRAGVGPKD	SHE	86	Q5VZ18
VGGAQVLATGKTPGA	TMEM273	16	Q5T292
PGKEGVKNAVGDSLG	SLC17A8	16	Q8NDX2
PLFEAVGGSGGKTLE	ATP6V0D2	276	Q8N8Y2
GKGLVGTVTKPVAGA	VPS13D	4186	Q5THJ4