Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GHR CXCR5 GABRE PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C GLRA2 GLRB FPR3 OR4K1 MFSD6 OR4F4 NPSR1 MC4R GLRA3 HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB TMEM63A

1.46e-1613536428GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

1.98e-138846421GO:0004930
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

ADRA1D ADRA2B ADRA2C HRH1 HRH2 TAAR5

3.51e-0941646GO:0008227
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

PROKR1 FPR3 NPSR1 MC4R SSTR2 BDKRB1 EDNRB

2.25e-07133647GO:0008528
GeneOntologyMolecularFunctionpeptide receptor activity

PROKR1 FPR3 NPSR1 MC4R SSTR2 BDKRB1 EDNRB

3.19e-07140647GO:0001653
GeneOntologyMolecularFunctionalpha-adrenergic receptor activity

ADRA1D ADRA2B ADRA2C

6.24e-076643GO:0004936
GeneOntologyMolecularFunctionextracellularly glycine-gated ion channel activity

GLRA2 GLRB GLRA3

6.24e-076643GO:0016933
GeneOntologyMolecularFunctionextracellularly glycine-gated chloride channel activity

GLRA2 GLRB GLRA3

6.24e-076643GO:0016934
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GABRE GLRA2 GLRB GLRA3 HRH1 HRH2

8.04e-07100646GO:0030594
GeneOntologyMolecularFunctioninhibitory extracellular ligand-gated monoatomic ion channel activity

GLRA2 GLRB GLRA3

1.74e-068643GO:0005237
GeneOntologyMolecularFunctiontransporter activity

SLC6A1 SLC7A8 GABRE SLC8A1 SLC46A3 SLC37A3 AQP11 GLRA2 SLC22A2 GLRB TMEM38A GLRA3 HRH1 MFSD2B LMBRD1 TMEM63A

2.11e-0612896416GO:0005215
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A1 SLC7A8 GABRE SLC8A1 SLC46A3 SLC37A3 AQP11 GLRA2 SLC22A2 GLRB TMEM38A GLRA3 HRH1 MFSD2B TMEM63A

3.53e-0611806415GO:0022857
GeneOntologyMolecularFunctionadrenergic receptor activity

ADRA1D ADRA2B ADRA2C

3.71e-0610643GO:0004935
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A1 GABRE SLC8A1 SLC46A3 SLC37A3 AQP11 GLRA2 GLRB TMEM38A GLRA3 HRH1 TMEM63A

4.39e-067586412GO:0015318
GeneOntologyMolecularFunctionglycine-gated chloride ion channel activity

GLRA2 GLRA3

1.01e-052642GO:0022852
GeneOntologyMolecularFunctionglycine binding

GLRA2 GLRB GLRA3

1.11e-0514643GO:0016594
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC6A1 GABRE SLC37A3 GLRA2 GLRB GLRA3

1.80e-05171646GO:0015103
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRE GLRA2 GLRB GLRA3

1.98e-0550644GO:0099095
GeneOntologyMolecularFunctionhormone binding

GHR ADRA2B ADRA2C MC4R EDNRB

1.98e-05103645GO:0042562
GeneOntologyMolecularFunctionalpha2-adrenergic receptor activity

ADRA2B ADRA2C

3.03e-053642GO:0004938
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRE GLRA2 GLRB TMEM38A GLRA3 TMEM63A

3.55e-05193646GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GABRE GLRA2 GLRB TMEM38A GLRA3 TMEM63A

3.98e-05197646GO:0022834
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC6A1 GABRE GLRA2 GLRB GLRA3

5.03e-05125645GO:0015108
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GABRE GLRA2 GLRB GLRA3

5.61e-0565644GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GABRE GLRA2 GLRB GLRA3

5.61e-0565644GO:0022824
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GABRE GLRA2 GLRB GLRA3

1.09e-0477644GO:0005230
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC6A1 GABRE GLRA2 GLRB GLRA3

1.23e-04151645GO:0008509
GeneOntologyMolecularFunctionepinephrine binding

ADRA2B ADRA2C

1.50e-046642GO:0051379
GeneOntologyMolecularFunctionhistamine receptor activity

HRH1 HRH2

1.50e-046642GO:0004969
GeneOntologyMolecularFunctionchloride channel activity

GABRE GLRA2 GLRB GLRA3

1.67e-0486644GO:0005254
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A1 GABRE SLC8A1 SLC46A3 GLRA2 GLRB TMEM38A GLRA3 HRH1 TMEM63A

2.00e-047936410GO:0015075
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GABRE GLRA2 GLRB GLRA3

3.34e-04103644GO:0005253
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

GLRA2 GLRB GLRA3

3.54e-0443643GO:0005231
GeneOntologyMolecularFunctionamine transmembrane transporter activity

SLC7A8 SLC22A2

3.59e-049642GO:0005275
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A1 SLC7A8 SLC8A1 SLC46A3 SLC37A3 MFSD2B

3.68e-04296646GO:0015291
GeneOntologyMolecularFunctionolfactory receptor activity

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

4.47e-04431647GO:0004984
GeneOntologyMolecularFunctiontoxin transmembrane transporter activity

SLC7A8 SLC22A2

6.54e-0412642GO:0019534
GeneOntologyMolecularFunctionneuropeptide receptor activity

PROKR1 NPSR1 SSTR2

6.56e-0453643GO:0008188
GeneOntologyMolecularFunctiongated channel activity

GABRE GLRA2 GLRB TMEM38A GLRA3 TMEM63A

6.94e-04334646GO:0022836
GeneOntologyMolecularFunctionpeptide hormone binding

GHR MC4R EDNRB

7.31e-0455643GO:0017046
GeneOntologyMolecularFunctioncatecholamine binding

ADRA2B ADRA2C

7.71e-0413642GO:1901338
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GABRE GLRA2 GLRB

8.12e-0457643GO:1904315
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A1 SLC7A8 SLC8A1 SLC46A3 SLC37A3 SLC22A2 MFSD2B

8.15e-04477647GO:0022804
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GABRE GLRA2 GLRB

9.43e-0460643GO:0099529
GeneOntologyMolecularFunctionchannel activity

GABRE AQP11 GLRA2 GLRB TMEM38A GLRA3 TMEM63A

1.42e-03525647GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GABRE AQP11 GLRA2 GLRB TMEM38A GLRA3 TMEM63A

1.44e-03526647GO:0022803
GeneOntologyMolecularFunctionamino acid binding

GLRA2 GLRB GLRA3

1.66e-0373643GO:0016597
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GABRE GLRA2 GLRB

1.80e-0375643GO:0098960
GeneOntologyMolecularFunctionimmune receptor activity

GHR CXCR5 FPR3 MFSD6

1.94e-03165644GO:0140375
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor activity

HRH1 HRH2

2.24e-0322642GO:0004993
GeneOntologyMolecularFunctionamide binding

GHR FPR3 LAPTM4B MC4R EDNRB

2.70e-03299645GO:0033218
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

TMEM38A TMEM63A

3.37e-0327642GO:0005227
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRE GLRA2 GLRB TMEM38A GLRA3 TMEM63A

3.47e-03459646GO:0005216
GeneOntologyMolecularFunctionpeptide binding

SLC7A8 FPR3 MC4R SSTR2 BDKRB1

3.51e-03318645GO:0042277
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

TMEM38A TMEM63A

4.43e-0331642GO:0022839
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A1 SLC7A8 SLC22A2

4.67e-03105643GO:0015171
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

SLC37A3 SLC22A2

5.31e-0334642GO:0042910
GeneOntologyMolecularFunctionneuropeptide binding

MC4R SSTR2

6.27e-0337642GO:0042923
GeneOntologyMolecularFunctionantiporter activity

SLC7A8 SLC8A1 SLC37A3

9.90e-03138643GO:0015297
GeneOntologyMolecularFunctionsymporter activity

SLC6A1 SLC46A3 MFSD2B

1.24e-02150643GO:0015293
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C GLRA2 GLRB FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 MFSD2B OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

2.34e-1313956024GO:0007186
GeneOntologyBiologicalProcessvascular process in circulatory system

SLC6A1 SLC7A8 SLC8A1 ADRA1D ADRA2B ADRA2C SLC22A2 HRH1 HRH2 EDNRB

5.26e-083446010GO:0003018
GeneOntologyBiologicalProcessvasoconstriction

SLC8A1 ADRA1D ADRA2B ADRA2C HRH1 HRH2 EDNRB

5.99e-08121607GO:0042310
GeneOntologyBiologicalProcesscirculatory system process

SLC6A1 SLC7A8 SLC8A1 ADRA1D ADRA2B ADRA2C SLC22A2 TMEM38A HRH1 HRH2 BDKRB1 EDNRB

1.08e-067336012GO:0003013
GeneOntologyBiologicalProcessblood vessel diameter maintenance

SLC8A1 ADRA1D ADRA2B ADRA2C HRH1 HRH2 EDNRB

1.94e-06202607GO:0097746
GeneOntologyBiologicalProcessregulation of tube diameter

SLC8A1 ADRA1D ADRA2B ADRA2C HRH1 HRH2 EDNRB

1.94e-06202607GO:0035296
GeneOntologyBiologicalProcessregulation of tube size

SLC8A1 ADRA1D ADRA2B ADRA2C HRH1 HRH2 EDNRB

2.00e-06203607GO:0035150
GeneOntologyBiologicalProcessinorganic anion transmembrane transport

SLC6A1 GABRE SLC37A3 GLRA2 GLRB GLRA3

2.52e-06134606GO:0098661
GeneOntologyBiologicalProcessregulation of blood circulation

SLC8A1 ADRA1D ADRA2B ADRA2C TMEM38A HRH1 HRH2 EDNRB

4.47e-06326608GO:1903522
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC6A1 GABRE SLC8A1 SLC46A3 SLC37A3 GLRA2 GLRB NPSR1 TMEM38A GLRA3 HRH1 BDKRB1 EDNRB

5.62e-0610176013GO:0098660
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC6A1 GABRE SLC8A1 SLC46A3 AQP11 GLRA2 SLC22A2 GLRB NPSR1 TMEM38A GLRA3 HRH1 BDKRB1 EDNRB TMEM63A

6.43e-0613746015GO:0006811
GeneOntologyBiologicalProcessregulation of vasoconstriction

ADRA1D ADRA2B ADRA2C HRH1 HRH2

9.70e-0698605GO:0019229
GeneOntologyBiologicalProcessinorganic anion transport

SLC6A1 GABRE SLC37A3 GLRA2 GLRB GLRA3

1.38e-05180606GO:0015698
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC6A1 GABRE SLC8A1 SLC46A3 GLRA2 GLRB NPSR1 TMEM38A GLRA3 HRH1 BDKRB1 EDNRB TMEM63A

1.51e-0511156013GO:0034220
GeneOntologyBiologicalProcessepinephrine transport

ADRA2B ADRA2C SLC22A2

1.55e-0517603GO:0048241
GeneOntologyBiologicalProcesspositive regulation of vasoconstriction

ADRA1D ADRA2C HRH1 HRH2

1.84e-0554604GO:0045907
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC6A1 GABRE GLRA2 GLRB GLRA3

1.86e-05112605GO:1902476
GeneOntologyBiologicalProcessneuropeptide signaling pathway

PROKR1 GLRA2 GLRB NPSR1 SSTR2

3.04e-05124605GO:0007218
GeneOntologyBiologicalProcesschloride transport

SLC6A1 GABRE GLRA2 GLRB GLRA3

3.54e-05128605GO:0006821
GeneOntologyBiologicalProcesssmooth muscle contraction

SLC8A1 ADRA2B ADRA2C SSTR2 EDNRB

4.25e-05133605GO:0006939
GeneOntologyBiologicalProcesspositive regulation of cytosolic calcium ion concentration

CXCR5 SLC8A1 ADRA1D FPR3 BDKRB1 EDNRB

4.71e-05224606GO:0007204
GeneOntologyBiologicalProcessreceptor transactivation

ADRA2B ADRA2C

4.97e-054602GO:0035624
GeneOntologyBiologicalProcessadenylate cyclase-activating adrenergic receptor signaling pathway

ADRA1D ADRA2B ADRA2C

5.14e-0525603GO:0071880
GeneOntologyBiologicalProcessregulation of anatomical structure size

SLC8A1 ADRA1D ADRA2B ADRA2C AQP11 HRH1 HRH2 XK EDNRB

6.94e-05618609GO:0090066
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

SLC6A1 GABRE GLRA2 GLRB GLRA3

8.27e-05153605GO:0098656
GeneOntologyBiologicalProcessvascular associated smooth muscle contraction

SLC8A1 ADRA2B EDNRB

9.93e-0531603GO:0014829
GeneOntologyBiologicalProcessblood circulation

SLC8A1 ADRA1D ADRA2B ADRA2C TMEM38A HRH1 HRH2 BDKRB1 EDNRB

9.96e-05648609GO:0008015
GeneOntologyBiologicalProcessadrenergic receptor signaling pathway

ADRA1D ADRA2B ADRA2C

1.43e-0435603GO:0071875
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 TAAR5 OR56A1 OR52A1

1.77e-04547608GO:0007606
GeneOntologyBiologicalProcessnorepinephrine transport

ADRA2B ADRA2C SLC22A2

1.84e-0438603GO:0015874
GeneOntologyBiologicalProcessregulation of release of sequestered calcium ion into cytosol

SLC8A1 NPSR1 TMEM38A BDKRB1

1.91e-0498604GO:0051279
GeneOntologyBiologicalProcessmonoatomic anion transport

SLC6A1 GABRE GLRA2 GLRB GLRA3

1.91e-04183605GO:0006820
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

2.50e-04432607GO:0050911
GeneOntologyBiologicalProcessregulation of system process

SLC8A1 ADRA1D ADRA2B ADRA2C NPSR1 TMEM38A HRH1 HRH2 EDNRB

2.54e-04734609GO:0044057
GeneOntologyBiologicalProcessnegative regulation of epinephrine secretion

ADRA2B ADRA2C

3.69e-0410602GO:0032811
GeneOntologyBiologicalProcesssensory perception of smell

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

3.90e-04465607GO:0007608
GeneOntologyBiologicalProcessnegative regulation of norepinephrine secretion

ADRA2B ADRA2C

4.50e-0411602GO:0010700
GeneOntologyBiologicalProcessregulation of epinephrine secretion

ADRA2B ADRA2C

4.50e-0411602GO:0014060
GeneOntologyBiologicalProcesscellular response to caffeine

SLC8A1 TMEM38A

4.50e-0411602GO:0071313
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

5.01e-04485607GO:0050907
GeneOntologyBiologicalProcessrighting reflex

GLRB NPSR1

5.39e-0412602GO:0060013
GeneOntologyBiologicalProcessregulation of uterine smooth muscle contraction

ADRA2B ADRA2C

5.39e-0412602GO:0070472
GeneOntologyBiologicalProcessphospholipase C-activating G protein-coupled receptor signaling pathway

ADRA1D FPR3 HRH1 EDNRB

6.09e-04133604GO:0007200
GeneOntologyBiologicalProcessepinephrine secretion

ADRA2B ADRA2C

6.36e-0413602GO:0048242
GeneOntologyBiologicalProcessether lipid biosynthetic process

CHPT1 PEDS1

6.36e-0413602GO:0008611
GeneOntologyBiologicalProcessuterine smooth muscle contraction

ADRA2B ADRA2C

6.36e-0413602GO:0070471
GeneOntologyBiologicalProcessglycerol ether biosynthetic process

CHPT1 PEDS1

6.36e-0413602GO:0046504
GeneOntologyBiologicalProcessamine transport

SLC6A1 ADRA2B ADRA2C SLC22A2

6.81e-04137604GO:0015837
GeneOntologyBiologicalProcesscellular response to purine-containing compound

SLC8A1 TMEM38A

7.40e-0414602GO:0071415
GeneOntologyBiologicalProcessether biosynthetic process

CHPT1 PEDS1

7.40e-0414602GO:1901503
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

HRH1 HRH2 SSTR2

7.47e-0461603GO:0007187
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

7.91e-04524607GO:0009593
GeneOntologyBiologicalProcessorganic cation transport

SLC7A8 ADRA2B ADRA2C SLC22A2

8.42e-04145604GO:0015695
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

SLC8A1 NPSR1 TMEM38A BDKRB1

8.64e-04146604GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

SLC8A1 NPSR1 TMEM38A BDKRB1

8.86e-04147604GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

SLC8A1 NPSR1 TMEM38A BDKRB1

9.32e-04149604GO:0051282
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

SLC8A1 NPSR1 TMEM38A HRH1 BDKRB1 EDNRB

9.56e-04392606GO:0070588
GeneOntologyBiologicalProcessregulation of eating behavior

NPSR1 MC4R

9.73e-0416602GO:1903998
GeneOntologyBiologicalProcesssequestering of calcium ion

SLC8A1 NPSR1 TMEM38A BDKRB1

1.03e-03153604GO:0051208
GeneOntologyBiologicalProcessmuscle contraction

SLC8A1 ADRA2B ADRA2C TMEM38A SSTR2 EDNRB

1.06e-03400606GO:0006936
GeneOntologyBiologicalProcessadenylate cyclase-modulating G protein-coupled receptor signaling pathway

ADRA1D ADRA2B ADRA2C MC4R SSTR2

1.45e-03286605GO:0007188
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

1.45e-03582607GO:0050906
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC6A1 SLC8A1 SLC46A3 NPSR1 TMEM38A HRH1 BDKRB1 EDNRB TMEM63A

1.51e-03942609GO:0098655
GeneOntologyBiologicalProcessresponse to caffeine

SLC8A1 TMEM38A

1.69e-0321602GO:0031000
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A1 SLC8A1 SLC46A3 SLC22A2 NPSR1 TMEM38A HRH1 BDKRB1 EDNRB TMEM63A

1.72e-0311576010GO:0006812
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

SLC8A1 TMEM38A

1.85e-0322602GO:0010881
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

GABRE GLRA2 GLRB GLRA3

1.87e-03180604GO:0060078
GeneOntologyBiologicalProcessnegative regulation of catecholamine secretion

ADRA2B ADRA2C

2.02e-0323602GO:0033604
GeneOntologyBiologicalProcessG protein-coupled serotonin receptor signaling pathway

HRH1 HRH2

2.02e-0323602GO:0098664
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC6A1 SLC7A8 SLC22A2

2.09e-0387603GO:0150104
GeneOntologyBiologicalProcessvascular transport

SLC6A1 SLC7A8 SLC22A2

2.15e-0388603GO:0010232
GeneOntologyBiologicalProcessglycerol ether metabolic process

CHPT1 PEDS1

2.20e-0324602GO:0006662
GeneOntologyBiologicalProcessether lipid metabolic process

CHPT1 PEDS1

2.20e-0324602GO:0046485
GeneOntologyBiologicalProcessadenylate cyclase-activating G protein-coupled receptor signaling pathway

ADRA1D ADRA2B ADRA2C MC4R

2.32e-03191604GO:0007189
GeneOntologyBiologicalProcesscellular response to ethanol

GLRA2 GLRA3

2.39e-0325602GO:0071361
GeneOntologyBiologicalProcessactivation of protein kinase B activity

ADRA2B ADRA2C

2.39e-0325602GO:0032148
GeneOntologyBiologicalProcessamino acid transport

SLC6A1 SLC7A8 SLC22A2 XK

2.50e-03195604GO:0006865
GeneOntologyBiologicalProcesssecretion

SLC6A1 ADRA2B ADRA2C SLC22A2 NPSR1 MC4R HRH2 C1QTNF3 EDNRB TMEM63A

2.56e-0312216010GO:0046903
GeneOntologyBiologicalProcessregulation of norepinephrine secretion

ADRA2B ADRA2C

2.59e-0326602GO:0014061
GeneOntologyBiologicalProcesscatecholamine transport

ADRA2B ADRA2C SLC22A2

2.76e-0396603GO:0051937
GeneOntologyBiologicalProcesssodium ion import across plasma membrane

SLC6A1 SLC8A1

2.79e-0327602GO:0098719
GeneOntologyBiologicalProcessregulation of muscle contraction

SLC8A1 ADRA2B ADRA2C TMEM38A

2.84e-03202604GO:0006937
GeneOntologyBiologicalProcessnorepinephrine secretion

ADRA2B ADRA2C

3.00e-0328602GO:0048243
GeneOntologyBiologicalProcesscellular response to zinc ion

GLRA2 GLRA3

3.00e-0328602GO:0071294
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction by calcium ion signaling

SLC8A1 TMEM38A

3.00e-0328602GO:0010882
GeneOntologyCellularComponentglycine-gated chloride channel complex

GLRB GLRA3

9.23e-062642GO:0016935
GeneOntologyCellularComponentchloride channel complex

GABRE GLRA2 GLRB GLRA3

2.79e-0557644GO:0034707
GeneOntologyCellularComponentendoplasmic reticulum membrane

SGPP1 TEX261 SLC37A3 REEP1 CHPT1 AQP11 TMEM38A PEDS1 CYP4X1 XK BFAR LMBRD1 TMEM86A GRAMD4

2.89e-0512936414GO:0005789
GeneOntologyCellularComponentglycinergic synapse

GLRA2 GLRB GLRA3

3.01e-0520643GO:0098690
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

SGPP1 TEX261 SLC37A3 REEP1 CHPT1 AQP11 TMEM38A PEDS1 CYP4X1 XK BFAR LMBRD1 TMEM86A GRAMD4

3.04e-0512996414GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

SGPP1 TEX261 SLC37A3 REEP1 CHPT1 AQP11 TMEM38A PEDS1 CYP4X1 XK BFAR LMBRD1 TMEM86A GRAMD4

3.85e-0513276414GO:0042175
GeneOntologyCellularComponentsynaptic membrane

SLC6A1 GABRE SLC8A1 ADRA2C GLRA2 SLC22A2 GLRB GLRA3 DENND1A

6.74e-05583649GO:0097060
GeneOntologyCellularComponentpostsynaptic membrane

SLC6A1 GABRE SLC8A1 ADRA2C GLRA2 GLRB GLRA3

2.34e-04405647GO:0045211
GeneOntologyCellularComponentlysosomal membrane

LAPTM4A SLC46A3 SLC37A3 LAPTM4B GPR137B LMBRD1 TMEM63A

5.16e-04462647GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

LAPTM4A SLC46A3 SLC37A3 LAPTM4B GPR137B LMBRD1 TMEM63A

5.16e-04462647GO:0098852
GeneOntologyCellularComponentvacuolar membrane

LAPTM4A SLC46A3 SLC37A3 LAPTM4B GPR137B LMBRD1 TMEM63A

8.91e-04507647GO:0005774
GeneOntologyCellularComponentsomatodendritic compartment

SLC6A1 GHR GABRE SLC8A1 ADRA2C AQP11 GLRB GLRA3 HRH1 HRH2 DENND1A

1.15e-0312286411GO:0036477
GeneOntologyCellularComponentGABA-ergic synapse

SLC6A1 GABRE GLRA2 GLRB

1.61e-03164644GO:0098982
GeneOntologyCellularComponentdendrite

GABRE SLC8A1 AQP11 GLRB GLRA3 HRH1 HRH2 DENND1A

4.52e-03858648GO:0030425
GeneOntologyCellularComponentdendritic tree

GABRE SLC8A1 AQP11 GLRB GLRA3 HRH1 HRH2 DENND1A

4.58e-03860648GO:0097447
DomainGPCR_Rhodpsn_7TM

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

3.17e-156706421IPR017452
Domain7tm_1

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

3.89e-156776421PF00001
DomainG_PROTEIN_RECEP_F1_1

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

4.91e-156856421PS00237
DomainG_PROTEIN_RECEP_F1_2

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

5.83e-156916421PS50262
DomainGPCR_Rhodpsn

CXCR5 PROKR1 OR4F5 OR52R1 ADRA1D ADRA2B ADRA2C FPR3 OR4K1 OR4F4 NPSR1 MC4R HRH1 OR4F17 HRH2 TAAR5 OR56A1 SSTR2 BDKRB1 OR52A1 EDNRB

6.00e-156926421IPR000276
Domain7TM_GPCR_Srsx

ADRA1D ADRA2B ADRA2C MC4R HRH1 HRH2 TAAR5 OR56A1 SSTR2 EDNRB

4.61e-121126410SM01381
DomainADR_fam

ADRA1D ADRA2B ADRA2C

4.53e-0610643IPR002233
DomainNeurotransmitter_ion_chnl_CS

GABRE GLRA2 GLRB GLRA3

1.68e-0545644IPR018000
DomainNeur_chan_memb

GABRE GLRA2 GLRB GLRA3

1.84e-0546644PF02932
DomainNeur_chan_LBD

GABRE GLRA2 GLRB GLRA3

2.00e-0547644PF02931
DomainNeur_channel

GABRE GLRA2 GLRB GLRA3

2.00e-0547644IPR006201
DomainNeur_chan_lig-bd

GABRE GLRA2 GLRB GLRA3

2.00e-0547644IPR006202
DomainNEUROTR_ION_CHANNEL

GABRE GLRA2 GLRB GLRA3

2.00e-0547644PS00236
DomainNeurotrans-gated_channel_TM

GABRE GLRA2 GLRB GLRA3

2.00e-0547644IPR006029
Domain-

GABRE GLRA2 GLRB GLRA3

2.00e-05476442.70.170.10
DomainMFS

SLC46A3 SLC37A3 SLC22A2 MFSD6 MFSD2B

3.42e-05108645PS50850
DomainLAPTM4/5

LAPTM4A LAPTM4B

3.46e-053642IPR004687
DomainMtp

LAPTM4A LAPTM4B

3.46e-053642PF03821
DomainGABAA/Glycine_rcpt

GABRE GLRA2 GLRA3

6.47e-0523643IPR006028
DomainGlycine_rcpt_A

GLRA2 GLRA3

6.90e-054642IPR008127
DomainMFS_dom

SLC46A3 SLC37A3 SLC22A2 MFSD6 MFSD2B

9.58e-05134645IPR020846
DomainOlfact_rcpt

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

3.83e-04393647IPR000725
DomainMFS

SLC46A3 SLC37A3 MFSD6

2.34e-0377643IPR011701
DomainMFS_1

SLC46A3 SLC37A3 MFSD6

2.34e-0377643PF07690
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

GHR GABRE ADRA1D ADRA2B ADRA2C GLRA2 GLRB FPR3 MC4R GLRA3 HRH1 HRH2 TAAR5 SSTR2 BDKRB1 EDNRB

4.50e-162724916M13380
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C FPR3 NPSR1 MC4R HRH1 HRH2 TAAR5 XK SSTR2 BDKRB1 EDNRB

1.94e-133304915M18334
PathwayREACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C FPR3 NPSR1 MC4R HRH1 HRH2 TAAR5 XK SSTR2 BDKRB1 EDNRB

2.22e-133334915MM14963
PathwayREACTOME_GPCR_LIGAND_BINDING

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C FPR3 NPSR1 MC4R HRH1 HRH2 TAAR5 XK SSTR2 BDKRB1 EDNRB

8.81e-124304915MM15160
PathwayREACTOME_GPCR_LIGAND_BINDING

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C FPR3 NPSR1 MC4R HRH1 HRH2 TAAR5 XK SSTR2 BDKRB1 EDNRB

2.52e-114634915M507
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

CXCR5 ADRA1D ADRA2B ADRA2C FPR3 MC4R HRH1 HRH2 SSTR2 BDKRB1 EDNRB

2.95e-111864911MM15994
PathwayWP_GPCRS_NONODORANT

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C NPSR1 MC4R HRH1 HRH2 SSTR2 BDKRB1 EDNRB

7.89e-112664912MM15843
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

CXCR5 ADRA1D ADRA2B ADRA2C FPR3 MC4R HRH1 HRH2 SSTR2 BDKRB1 EDNRB

1.07e-092604911M39397
PathwayREACTOME_SIGNALING_BY_GPCR

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C FPR3 NPSR1 MC4R HRH1 HRH2 TAAR5 XK SSTR2 BDKRB1 EDNRB

2.59e-096464915MM14962
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

ADRA1D ADRA2B ADRA2C HRH1 HRH2 TAAR5

6.13e-0942496M5868
PathwayREACTOME_AMINE_LIGAND_BINDING_RECEPTORS

ADRA1D ADRA2B ADRA2C HRH1 HRH2 TAAR5

6.13e-0942496MM14971
PathwayREACTOME_SIGNALING_BY_GPCR

CXCR5 PROKR1 ADRA1D ADRA2B ADRA2C FPR3 NPSR1 MC4R HRH1 HRH2 TAAR5 XK SSTR2 BDKRB1 EDNRB

8.01e-097024915M746
PathwayREACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

CXCR5 PROKR1 FPR3 NPSR1 MC4R XK SSTR2 BDKRB1 EDNRB

2.15e-08197499M12289
PathwayREACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS

CXCR5 PROKR1 FPR3 NPSR1 MC4R XK SSTR2 BDKRB1 EDNRB

2.15e-08197499MM14970
PathwayWP_MONOAMINE_GPCRS

ADRA1D ADRA2B ADRA2C HRH1 HRH2

6.53e-0831495MM15871
PathwayWP_MONOAMINE_GPCRS

ADRA1D ADRA2B ADRA2C HRH1 HRH2

9.08e-0833495M39585
PathwayWP_GPCRS_PEPTIDE

CXCR5 FPR3 MC4R SSTR2 BDKRB1 EDNRB

1.42e-0770496MM15959
PathwayWP_PEPTIDE_GPCRS

CXCR5 FPR3 MC4R SSTR2 BDKRB1 EDNRB

2.16e-0775496M39696
PathwayREACTOME_ADRENOCEPTORS

ADRA1D ADRA2B ADRA2C

3.27e-069493M27302
PathwayREACTOME_ADRENOCEPTORS

ADRA1D ADRA2B ADRA2C

3.27e-069493MM15009
PathwayWP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION

SLC6A1 ADRA2B ADRA2C GLRA2 GLRB GLRA3

6.04e-06132496M48110
PathwayWP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE

ADRA1D ADRA2B ADRA2C

2.14e-0516493M39849
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ADRA1D HRH1 BDKRB1 EDNRB

2.64e-0550494M47951
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

SLC8A1 ADRA1D HRH1 HRH2 BDKRB1 EDNRB

3.32e-05178496M2890
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

PROKR1 ADRA1D NPSR1 HRH1 BDKRB1 EDNRB

8.34e-05210496MM15043
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR4F5 OR52R1 REEP1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

8.53e-05417498M4072
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

PROKR1 ADRA1D NPSR1 HRH1 BDKRB1 EDNRB

9.99e-05217496M18437
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR4F5 OR52R1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

3.65e-04389497M14091
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

CXCR5 ADRA2B ADRA2C FPR3 SSTR2 BDKRB1

4.70e-04289496MM15057
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

CXCR5 ADRA2B ADRA2C FPR3 SSTR2 BDKRB1

7.27e-04314496M600
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

SLC6A1 GLRA2 SLC22A2 GLRB GLRA3

8.00e-04211495MM14502
PathwayREACTOME_SENSORY_PERCEPTION

OR4F5 OR52R1 REEP1 OR4K1 OR4F4 OR4F17 OR56A1 OR52A1

1.44e-03636498M41834
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

NPSR1 MC4R HRH2 TAAR5

1.51e-03143494MM15055
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC22A2

1.95e-0319492MM15107
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A1 SLC22A2

1.95e-0319492M27362
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

NPSR1 MC4R HRH2 TAAR5

2.12e-03157494M4904
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

SLC6A1 GLRA2 SLC22A2 GLRB GLRA3

2.38e-03270495M15514
PathwayWP_GPCRS_OTHER

ADRA1D TAAR5 SSTR2

4.11e-0393493M39629
PathwayWP_GABA_RECEPTOR_SIGNALING

SLC6A1 GABRE

5.16e-0331492M39369
PathwayREACTOME_G_ALPHA_Z_SIGNALLING_EVENTS

ADRA2B ADRA2C

5.83e-0333492MM15058
PathwayREACTOME_NEURONAL_SYSTEM

SLC6A1 GLRA2 SLC22A2 GLRB GLRA3

5.96e-03335495MM14503
Pubmed

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.

ADRA1D ADRA2B ADRA2C HRH1 HRH2 TAAR5 SSTR2 BDKRB1

3.49e-0920064818240029
Pubmed

Expression and mRNA splicing of glycine receptor subunits and gephyrin during neuronal differentiation of P19 cells in vitro, studied by RT-PCR and immunocytochemistry.

GLRA2 GLRB GLRA3

2.37e-0846439051263
Pubmed

Activation of glycine receptor phase-shifts the circadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus.

GLRA2 GLRB GLRA3

2.37e-08464321486797
Pubmed

Dissociation of heterotrimeric g proteins in cells.

CXCR5 ADRA2C FPR3 HRH1 SSTR2 BDKRB1 EDNRB

4.13e-0817964718577758
Pubmed

Developmental regulation of glycine receptors at efferent synapses of the murine cochlea.

GLRA2 GLRB GLRA3

5.93e-08564321850450
Pubmed

Native glycine receptor subtypes and their physiological roles.

GLRA2 GLRB GLRA3

5.93e-08564318721822
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

SLC6A1 GABRE ADRA1D GLRA2 GLRB GLRA3 SSTR2 BDKRB1

8.13e-0830064819086053
Pubmed

Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes.

ADRA1D ADRA2B ADRA2C

1.18e-07664317636168
Pubmed

Cardiac function in genetically engineered mice with altered adrenergic receptor signaling.

ADRA1D ADRA2B ADRA2C

3.31e-0786439139936
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

GABRE GLRA2 GLRB GLRA3 SSTR2

4.14e-078164522723691
Pubmed

Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.

ADRA1D ADRA2B ADRA2C

4.95e-07964321209093
Pubmed

Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.

LAPTM4A TMEM161A SLC22A2 LAPTM4B

2.25e-065064431318583
Pubmed

Selective glycine receptor α2 subunit control of crossover inhibition between the on and off retinal pathways.

GLRA2 GLRA3

3.33e-06264222399754
Pubmed

Histamine H1 and H2 receptors but not H4 receptors are upregulated during bone marrow regeneration.

HRH1 HRH2

3.33e-06264217420012
Pubmed

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors.

HRH1 HRH2

3.33e-06264211574888
Pubmed

Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries.

ADRA1D ADRA2C

3.33e-06264220599923
Pubmed

Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen.

HRH1 HRH2

3.33e-06264217312123
Pubmed

Differential activation of dual signaling responses by human H1 and H2 histamine receptors.

HRH1 HRH2

3.33e-06264212680587
Pubmed

Characterization of histamine projections and their potential cellular targets in the mouse retina.

HRH1 HRH2

3.33e-06264219015005
Pubmed

Evidence for a histaminergic system in the human testis.

HRH1 HRH2

3.33e-06264215820830
Pubmed

Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis.

HRH1 HRH2

3.33e-06264224371118
Pubmed

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.

LAPTM4A SLC22A2

3.33e-06264221553234
Pubmed

Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response.

HRH1 HRH2

3.33e-06264212429384
Pubmed

Demonstration of histamine H1 and H2 receptors in chondrocytes of human osteoarthritic cartilage.

HRH1 HRH2

3.33e-06264215928843
Pubmed

Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies.

GLRB GLRA3

3.33e-06264211496371
Pubmed

H1 and H2 receptors mediate postexercise hyperemia in sedentary and endurance exercise-trained men and women.

HRH1 HRH2

3.33e-06264216888049
Pubmed

Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.

GLRA2 GLRA3

3.33e-06264227382060
Pubmed

Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

ADRA2B ADRA2C

3.33e-0626428670422
Pubmed

Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.

ADRA2B HRH2

3.33e-06264232385805
Pubmed

Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells.

HRH1 HRH2

3.33e-06264211898002
Pubmed

Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice.

HRH1 HRH2

3.33e-06264220566747
Pubmed

Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits.

GLRA2 GLRB

3.33e-06264222606311
Pubmed

Characterization of the regulatory regions of murine alpha 2C2 adrenoceptor subtype gene.

ADRA2B ADRA2C

3.33e-0626428762185
Pubmed

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

ADRA2B ADRA2C

3.33e-0626422842764
Pubmed

Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.

GLRA2 GLRA3

3.33e-06264228784756
Pubmed

Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.

OR4F4 OR4F17

3.33e-06264211689484
Pubmed

Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.

OR4F4 OR4F17

3.33e-06264211689483
Pubmed

The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury.

HRH1 HRH2

3.33e-06264216051691
Pubmed

Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells.

HRH1 HRH2

3.33e-06264214982842
Pubmed

Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.

HRH1 HRH2

3.33e-06264217145090
Pubmed

Histamine receptors expressed in circulating progenitor cells have reciprocal actions in ligation-induced arteriosclerosis.

HRH1 HRH2

3.33e-06264224200155
Pubmed

Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.

HRH1 HRH2

3.33e-06264225664905
Pubmed

Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice.

ADRA2B ADRA2C

3.33e-0626429421280
Pubmed

Genetical genomic determinants of alcohol consumption in rats and humans.

GABRE ADRA2B ADRA2C GLRA2 GLRB

4.31e-0613064519874574
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

SLC6A1 TMEM161A CHPT1 LAPTM4B NPSR1 MC4R HRH1 BDKRB1 TMEM63A

5.10e-0669764928298427
Pubmed

Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata.

HRH1 HRH2

9.99e-06364216738217
Pubmed

Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy.

HRH1 HRH2

9.99e-06364211603849
Pubmed

Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.

ADRA2B ADRA2C

9.99e-06364215592690
Pubmed

Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.

ADRA2B ADRA2C

9.99e-06364210385696
Pubmed

Epidermal growth factor receptor - but not histamine receptor - is upregulated in seasonal allergic rhinitis.

HRH1 HRH2

9.99e-06364212757445
Pubmed

Association between common genetic variants of α2A-, α2B-, and α2C-adrenergic receptors and ischemic stroke.

ADRA2B ADRA2C

9.99e-06364222560155
Pubmed

Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.

ADRA2B ADRA2C

9.99e-06364212946937
Pubmed

Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.

ADRA2B ADRA2C

9.99e-06364210647009
Pubmed

Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins.

HRH1 HRH2

9.99e-06364220203300
Pubmed

Blastocyst H(2) receptor is the target for uterine histamine in implantation in the mouse.

HRH1 HRH2

9.99e-06364210821762
Pubmed

Resting sympathetic nerve activity is related to age, sex and arterial pressure but not to α2-adrenergic receptor subtype.

ADRA2B ADRA2C

9.99e-06364220613626
Pubmed

Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity.

HRH1 HRH2

9.99e-06364225680462
Pubmed

Nefopam but not physostigmine affects the thermoregulatory response in mice via alpha(2)-adrenoceptors.

ADRA2B ADRA2C

9.99e-06364219744502
Pubmed

Effect on diurnal intraocular pressure variation of eliminating the alpha-2 adrenergic receptor subtypes in the mouse.

ADRA2B ADRA2C

9.99e-06364218326714
Pubmed

Linkage mapping of alpha-2 adrenergic receptor genes to mouse chromosomes 2 and 5.

ADRA2B ADRA2C

9.99e-0636428281014
Pubmed

The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.

PROKR1 MC4R

9.99e-06364226829592
Pubmed

Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice.

ADRA2B ADRA2C

9.99e-06364211181434
Pubmed

Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs.

HRH1 HRH2

9.99e-06364224236486
Pubmed

Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis.

HRH1 HRH2

9.99e-06364219762454
Pubmed

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells.

ADRA2B ADRA2C

9.99e-06364217215105
Pubmed

Function of brain α2B-adrenergic receptor characterized with subtype-selective α2B antagonist and KO mice.

ADRA2B ADRA2C

9.99e-06364227751959
Pubmed

Role of histamine and its receptors in cerebral ischemia.

HRH1 HRH2

9.99e-06364222860191
Pubmed

Distribution of mRNA encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2A subtype in apoptosis.

ADRA2B ADRA2C

9.99e-0636429415717
Pubmed

Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals.

ADRA2B ADRA2C

9.99e-0636428843087
Pubmed

Insertion/insertion genotype of α(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus.

ADRA2B ADRA2C

9.99e-06364220692245
Pubmed

Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine.

ADRA2B ADRA2C

9.99e-06364217261653
Pubmed

Polymorphisms of adrenoceptors are not associated with an increased risk of adverse event in heart failure: a MERIT-HF substudy.

ADRA2B ADRA2C

9.99e-06364219477404
Pubmed

Glycinergic input of small-field amacrine cells in the retinas of wildtype and glycine receptor deficient mice.

GLRA2 GLRA3

9.99e-06364217920294
Pubmed

Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine.

HRH1 HRH2

9.99e-06364218258331
Pubmed

International Union of Pharmacology. XIII. Classification of histamine receptors.

HRH1 HRH2

9.99e-0636429311023
Pubmed

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.

ADRA2B ADRA2C

9.99e-06364237841583
Pubmed

Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice.

ADRA2B ADRA2C

9.99e-06364211927164
Pubmed

Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease.

HRH1 HRH2

9.99e-06364218227221
Pubmed

Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.

ADRA2B ADRA2C

9.99e-06364226427149
Pubmed

Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors.

ADRA2B ADRA2C

9.99e-06364211125002
Pubmed

Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.

ADRA2B ADRA2C

9.99e-06364217075569
Pubmed

Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism.

HRH1 HRH2

9.99e-06364222169095
Pubmed

Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes.

ADRA2B ADRA2C

9.99e-06364212764077
Pubmed

Splice-specific roles of glycine receptor alpha3 in the hippocampus.

GLRB GLRA3

9.99e-06364219723286
Pubmed

The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders.

HRH1 HRH2

2.00e-05464217288995
Pubmed

Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.

OR4F4 OR4F17

2.00e-0546429384599
Pubmed

Glycinergic input of widefield, displaced amacrine cells of the mouse retina.

GLRA2 GLRA3

2.00e-05464219528249
Pubmed

Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis.

HRH1 HRH2

2.00e-05464223772030
Pubmed

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV.

LAPTM4A LAPTM4B

2.00e-05464221224396
Pubmed

Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.

HRH1 HRH2

2.00e-05464217627982
Pubmed

Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.

GLRB GLRA3

2.00e-05464228883437
Pubmed

Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema.

HRH1 HRH2

2.00e-05464215953854
Pubmed

Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response.

ADRA2B ADRA2C

2.00e-05464215920038
Pubmed

The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.

ADRA2B ADRA2C

2.00e-05464210224112
Pubmed

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

HRH1 HRH2

2.00e-05464212576552
Pubmed

Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system.

HRH1 HRH2

2.00e-05464222678907
Pubmed

The neglected role of histamine in Alzheimer's disease.

HRH1 HRH2

2.00e-05464223677734
Pubmed

Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.

ADRA1D ADRA2C

2.00e-05464226739946
Pubmed

Stable association between G alpha(q) and phospholipase C beta 1 in living cells.

ADRA1D HRH1 BDKRB1 EDNRB

2.93e-059564416754659
Pubmed

Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance.

ADRA2B ADRA2C

3.32e-05564215719258
InteractionSLC22A2 interactions

LAPTM4A TMEM161A CHPT1 SLC22A2 GLRB LAPTM4B

9.32e-0882556int:SLC22A2
GeneFamilyGlycine receptors

GLRA2 GLRB GLRA3

1.64e-075473868
GeneFamilyAdrenoceptors

ADRA1D ADRA2B ADRA2C

1.37e-069473169
GeneFamilyHistamine receptors

HRH1 HRH2

3.96e-054472187
GeneFamilySolute carriers

SLC6A1 SLC7A8 SLC8A1 SLC46A3 SLC37A3 SLC22A2 SLC35F5

6.67e-05395477752
GeneFamilyOlfactory receptors, family 4

OR4F5 OR4K1 OR4F4 OR4F17

3.48e-04129474151
GeneFamilyOlfactory receptors, family 52

OR52R1 OR52A1

7.20e-0349472165
CoexpressionGSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP

SLC46A3 FPR3 MFSD6 CD53 GPR137B HRH2

6.97e-06199616M5694
CoexpressionAtlaskidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_1000

SGPP1 GHR SLC7A8 SLC8A1 ADRA2B CHPT1 AQP11 SLC22A2 GPR137B LMBRD1 EDNRB

4.08e-067785511gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_1000
CoexpressionAtlaskidney_adult_CortVasc_Tie2_k-means-cluster#1_top-relative-expression-ranked_1000

SGPP1 GHR SLC7A8 CHPT1 AQP11 SLC22A2 GPR137B

1.60e-05314557gudmap_kidney_adult_CortVasc_Tie2_k1_1000
CoexpressionAtlaskidney_adult_JuxtaGlom_Ren1_Captopr_k-means-cluster#2_top-relative-expression-ranked_1000

SGPP1 GHR SLC7A8 ADRA2B CHPT1 AQP11 SLC22A2 GPR137B

1.68e-05441558gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_k2_1000
CoexpressionAtlaskidney_adult_Podocyte_MafB_k-means-cluster#2_top-relative-expression-ranked_1000

LAPTM4A MFSD6 KDM7A LMBRD1 TMEM63A

3.31e-05142555gudmap_kidney_adult_Podocyte_MafB_k2_1000
CoexpressionAtlaskidney_adult_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

SGPP1 GHR SLC7A8 SLC8A1 CHPT1 AQP11 SLC22A2 MFSD6 GPR137B EDNRB

3.39e-057995510gudmap_kidney_adult_JuxtaGlom_Ren1_1000
CoexpressionAtlaskidney_adult_CortVasc_Tie2_top-relative-expression-ranked_1000

SGPP1 GHR SLC7A8 CHPT1 AQP11 SLC22A2 MFSD6 GPR137B EDNRB TMEM63A

5.49e-058465510gudmap_kidney_adult_CortVasc_Tie2_1000
CoexpressionAtlaskidney_adult_RenalCortexMixed_Std_top-relative-expression-ranked_1000

SGPP1 GHR SLC7A8 ADRA2B CHPT1 AQP11 SLC22A2 GPR137B C1QTNF3 LMBRD1

6.36e-058615510gudmap_kidney_adult_RenalCortexMixed_Std_1000
CoexpressionAtlaskidney_adult_RenalCortexMixed_Std_top-relative-expression-ranked_500

GHR SLC7A8 CHPT1 AQP11 SLC22A2 GPR137B C1QTNF3

1.07e-04424557gudmap_kidney_adult_RenalCortexMixed_Std_500
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

SLC7A8 SLC8A1 FPR3 GPR137B HRH1 HRH2 DENND1A

1.21e-0819364731c0978ba78c9516d498aec0798902e57555e557
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Erythrophagocytic_macrophages|bone_marrow / Manually curated celltypes from each tissue

SLC7A8 SLC8A1 FPR3 GPR137B TMEM86A EDNRB

2.33e-07180646daf69a548ed7c6f285a6adcff00f99aa22f9d6a5
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SLC6A1 ADRA1D ADRA2B ADRA2C CYP4X1 HRH2

3.41e-0719264655f95454399fd533df75db06584eaa48d6ee3830
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 FPR3 GPR137B HRH1 HRH2 DENND1A

4.08e-07198646c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC6A1 ADRA2B SLC22A2 CYP4X1 SSTR2

7.54e-061886450a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCellmyeloid-macrophage|myeloid / Lineage and Cell class

SLC7A8 FPR3 GPR137B CYP4X1 EDNRB

7.74e-061896457c7dc5361250d6848c4050f8ef995561a0984a44
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC8A1 FPR3 HRH1 HRH2 DENND1A

7.94e-061906452d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLC6A1 ADRA1D ADRA2C CYP4X1 HRH2

7.94e-0619064510125091ad648163777b02e9f0d5e8d7f17d44a5
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

SLC8A1 FPR3 GPR137B HRH2 DENND1A

8.14e-06191645cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC7A8 SLC8A1 FPR3 GPR137B HRH1

8.14e-0619164524d75b7e1d6fb9d24aa7844f584ee888a449841f
ToppCellControl-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

SLC6A1 SLC8A1 ADRA2C HRH2 EDNRB

8.14e-061916452da83c493e60ad0278848957645277d76737a188
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC6A1 ADRA1D ADRA2C CYP4X1 HRH2

8.35e-061926455000440dc1ed17e7474d340921bdff945646f27e
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

SLC7A8 SLC8A1 FPR3 HRH1 DENND1A

8.56e-0619364564d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCell11.5-Distal-Mesenchymal-Pericyte|Distal / Age, Tissue, Lineage and Cell class

SLC6A1 ADRA1D ADRA2B CYP4X1 HRH2

8.78e-0619464508701590496cf85ff790e54a81493c61177e76ff
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|lung / Disease (COVID-19 only), tissue and cell type

SLC8A1 FPR3 CD53 GPR137B DENND1A

9.00e-06195645148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCellcontrol-Myeloid-Non-resident_Macrophage|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SLC8A1 FPR3 CD53 HRH2 EDNRB

9.23e-06196645646a8d47dddffdfd2d8a62245ea6cd49f9510a1a
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.23e-061966457c8aa5853d7096628e35af665097c0299c329753
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.23e-06196645f60b220ed117bcc33e0f7bbf5b53d3b1422ebaca
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.23e-06196645bcd274db4955ea76ca26267a272c7d1929db24f4
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.23e-0619664580b9139d91dda4de69830d2d443859e047ab5503
ToppCell10x3'2.3-week_17-19-Myeloid_macrophage-stroma-stromal_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 FPR3 GPR137B HRH1 TMEM86A

9.23e-0619664588517bb92be2f05c1e1ad94af22ac10d8c5c13c7
ToppCellMild_COVID-19-Myeloid-MoAM1|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.23e-06196645ea3fbe81b4ecb6ccc8031f6d99da93c9f9f8c1aa
ToppCellNS-control-d_0-4-Myeloid-Non-resident_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SLC8A1 FPR3 CD53 HRH2 EDNRB

9.46e-06197645496a1115071a1be6928786192de49f3adf197dfb
ToppCellBAL-Mild-Myeloid-MoAM|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.46e-061976450f40dd3530eb8d02e79b32f942efe3b65b8f6ee6
ToppCellBAL-Mild-Myeloid-MoAM|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SLC8A1 FPR3 HRH2 SSTR2 EDNRB

9.46e-06197645a6aa5991d566c28440f7e24a30933e69669064f2
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

SLC8A1 FPR3 CD53 GPR137B DENND1A

9.69e-061986459bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 FPR3 HRH1 HRH2 DENND1A

1.02e-05200645179afc4bee7a2fd85a3b5dadf32544a63807c164
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 FPR3 GPR137B HRH2 DENND1A

1.02e-05200645ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCellBronchial-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 FPR3 GPR137B HRH2 DENND1A

1.02e-052006452f5b71e55c2de0e77fdae6667eb57f333acc6cd1
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 FPR3 GPR137B HRH2 DENND1A

1.02e-0520064546f9c28b24e39acdf0481a02b6eb86ecdd83c504
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 FPR3 GPR137B HRH1 TMEM86A

1.02e-05200645af743dfef7e7cfaef1c494999757123f93a213e3
ToppCelldroplet-Liver-HEPATOCYTES-1m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A1 PROKR1 SLC8A1 CD53

7.15e-0515464466c93733116e31b65dfb4b0b00de5c39d19cdb84
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_2|343B / Donor, Lineage, Cell class and subclass (all cells)

SLC8A1 ADRA2B FPR3 HRH1

7.33e-0515564484221a285277292f7225eb69508c887541abeed1
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC6A1 GABRE LAPTM4B GLRA3

7.70e-05157644741d79c10cb87fa7f14080c6fccb1553c3a20bad
ToppCellControl-APC-like-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

SLC7A8 SLC8A1 GLRA3 HRH2

8.29e-05160644463dd624ca5c375b6ff7c269f4ef4b9d74f4b669
ToppCellMild_COVID-19-Myeloid-MoAM2|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

SLC8A1 FPR3 HRH2 SSTR2

8.70e-05162644e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REEP1 MFSD2B TBC1D21 TMEM63A

8.91e-05163644953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

SLC8A1 FPR3 HRH2 DENND1A

9.56e-05166644be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR CHPT1 SLC22A2 C1QTNF3

9.56e-051666448ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCellControl-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

SLC37A3 FPR3 HRH2 EDNRB

9.78e-051676446e5140527437193f441ca96893b9a00d346614f3
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR CHPT1 SLC22A2 C1QTNF3

1.00e-04168644b14fd50232887b6dca1f39014d43c6f66e5c3b5c
ToppCellfacs-Kidney|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2B CHPT1 SLC22A2 CD53

1.00e-04168644d2f17a470e04f8f0edb111894027bcfc6ee1a12f
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC8A1 FPR3 CD53 GPR137B

1.02e-04169644818ab7a6fd1940a22d3bd99fe15f0af888af6b3e
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC8A1 FPR3 CD53 GPR137B

1.02e-04169644f982f2e0d341fa27229f443ebe5c0e4a9e63bda6
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A8 SLC8A1 SLC22A2 HRH1

1.05e-04170644a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Red_blood_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHPT1 MFSD2B XK KDM7A

1.15e-04174644001254db9f4c346d06d31a7fa1213498f92e4280
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Red_blood_cells-RBC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHPT1 MFSD2B XK KDM7A

1.15e-04174644ce2bc1797707c3f48ef551de7edbfd7b47e5a36e
ToppCelldroplet-Liver-Npc-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A8 SLC8A1 CD53 TMEM86A

1.17e-041756441973fff0d7e1a94b31f461a39b91cc7984ebd8f1
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC7A8 SLC8A1 SLC22A2 HRH1

1.17e-04175644f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCelldroplet-Fat-Bat-18m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C REEP1 AQP11 TMEM86A

1.28e-04179644e6224864eb76a2e9c1fc0c61513d9e936bb5c72c
ToppCelldroplet-Fat-Bat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C REEP1 AQP11 TMEM86A

1.28e-041796449863ab3ceb160a4b1d9790033a4ac48845863d65
ToppCelldroplet-Fat-Bat-18m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA2C REEP1 AQP11 TMEM86A

1.28e-04179644dfe110add7228cd834b35916cbcc849769a01bb9
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC6A1 GLRA2 BSPH1 SLC22A2

1.31e-04180644c6030e725e3d86d5d74a1676330c77ffeceb324f
ToppCellControl-Myeloid-Dendritic_cells|Control / group, cell type (main and fine annotations)

SLC8A1 FPR3 CD53 HRH2

1.31e-0418064425ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGPP1 ADRA2B CHPT1 SLC22A2

1.36e-04182644faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGPP1 ADRA2B CHPT1 SLC22A2

1.36e-04182644be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCellNasal_Brush-Immune-Dendritic_cells|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC8A1 FPR3 CD53 HRH2

1.39e-04183644b1daec831990a53e846c089cebfcf4f8440820e4
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Nefm_(Deep_layer_pyramidal_cells--layer_5)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ADAM18 NPSR1 MC4R

1.40e-04706433fe560cd34a8f264f33dca1479950a60d10a16d9
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

GPR137B HRH1 HRH2 DENND1A

1.45e-04185644ab5704b96f1d368911308797d10c7c52766ab134
ToppCellMonocytes-M2-like_CD16+_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

SLC7A8 FPR3 HRH1 TMEM86A

1.51e-0418764459e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SGPP1 SLC8A1 CHPT1 EDNRB

1.51e-04187644b7689e7f6511920cd2beff27389555fddf685f61
ToppCell11.5-Airway-Mesenchymal-Pericyte|Airway / Age, Tissue, Lineage and Cell class

ADRA1D CYP4X1 HRH2 EDNRB

1.54e-04188644916971d8660fd20f616346953874e89d2cd13e88
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic|GI_large-bowel / Manually curated celltypes from each tissue

SLC7A8 FPR3 HRH1 HRH2

1.54e-04188644d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes|GI_large-bowel / Manually curated celltypes from each tissue

SLC7A8 FPR3 HRH1 HRH2

1.54e-041886440bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A1 SLC8A1 REEP1 HRH2

1.57e-04189644127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A1 SLC8A1 REEP1 HRH2

1.57e-041896442cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellCOVID-19-Heart-Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC8A1 FPR3 HRH1 DENND1A

1.57e-041896442586f4088721c5debec86c2b211b739fd33713eb
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC8A1 FPR3 HRH1 DENND1A

1.61e-04190644f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell10x5'-bone_marrow-Myeloid_Mac-Erythrophagocytic_macrophages|bone_marrow / Manually curated celltypes from each tissue

SLC7A8 FPR3 GPR137B CYP4X1

1.61e-041906449db04555c98eca1df15d144fbb499e0ba06660d5
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

SLC8A1 FPR3 CD53 GPR137B

1.64e-041916443b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 ADRA1D ADRA2B REEP1

1.64e-041916445c1f5b6c115b1b27b4a7467a6550ce43c01cf6d0
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SGPP1 SLC8A1 CHPT1 EDNRB

1.64e-0419164465083daf317f66556dc047eb19297dcbe9c70299
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A1 ADRA1D ADRA2B REEP1

1.67e-04192644eb9a0b3d32f90f8b95905c740aab21639dae5cbd
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC8A1 HRH2 KDM7A DENND1A

1.71e-0419364458e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SLC6A1 SLC8A1 ADRA1D EDNRB

1.71e-04193644360079cbaa18b74e4a48c5de40844faca076e1a6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SGPP1 SLC8A1 CHPT1 EDNRB

1.71e-04193644d994b2f2707877288f88cab7cd6002ef91962c50
ToppCellmyeloid-macrophage|World / Lineage and Cell class

SLC7A8 FPR3 GPR137B EDNRB

1.71e-04193644b13e694123b87ed8ad1786feb996398ddd84e94b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC8A1 FPR3 CD53 HRH2

1.74e-0419464496f16bcd393a0d3f8df479b172b5360ae5a1e663
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC8A1 FPR3 CD53 HRH2

1.74e-041946443043f6230fa723037c8cf7123f611ae847b39fd4
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC7A8 SLC8A1 FPR3 TMEM86A

1.74e-041946448e2819a9d0529f7b2de1a7c1190575175d6173ee
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

SLC7A8 SLC8A1 FPR3 DENND1A

1.74e-04194644800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellNasal_Brush-Immune|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC8A1 FPR3 CD53 HRH2

1.74e-041946443135bc4a8112c5dee108e3b8e775f508b65191f1
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC8A1 FPR3 HRH2 DENND1A

1.74e-04194644663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC8A1 FPR3 CD53 HRH2

1.77e-0419564491a3c439f10c03c5d51d904f512b6a08040edc76
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

SLC8A1 FPR3 GPR137B DENND1A

1.77e-04195644c172c5599379c29123340621a36bfb1fc90c2115
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SGPP1 SLC8A1 CHPT1 EDNRB

1.77e-041956443f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLC7A8 SLC8A1 FPR3 HRH1

1.77e-04195644312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

SLC8A1 FPR3 CD53 DENND1A

1.77e-0419564455e25f702af19146a161861cfd15f40bbda1dc35
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SGPP1 SLC8A1 CHPT1 EDNRB

1.77e-04195644e94bac6a5c788ee160d7feaf2a3c512a3691f995
ToppCell10x5'v1-week_14-16-Myeloid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 FPR3 GPR137B HRH1

1.81e-04196644e0447ad2efb021b63c7fef000d39b6b21fbe6113
ToppCellsevere_COVID-19-Non-classical_Monocyte|severe_COVID-19 / disease group, cell group and cell class (v2)

SLC7A8 SLC8A1 FPR3 GPR137B

1.81e-0419664434c1c74cad5e23196e86cfd6f19c836fe57b2264
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC8A1 HRH2 KDM7A DENND1A

1.81e-04196644cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A8 LAPTM4A SLC8A1 SLC22A2

1.81e-041966443cf73ed99f3efa76b632c16a8b98b6b7758ff63f
ToppCellBronchial_Biopsy-Immune-Dendritic_cells|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC8A1 FPR3 CD53 HRH2

1.81e-04196644bd828596c5b3fd5e4156f555e532f3de99d32f92
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GHR ADRA2C SSTR2 EDNRB

1.81e-04196644ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GHR ADRA2C SSTR2 EDNRB

1.81e-0419664430ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SLC7A8 FPR3 GPR137B HRH1

1.81e-041966443bca88eede3dd7368715ced02e3bacd1e3e82cab
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC8A1 FPR3 CD53 GPR137B

1.81e-041966447026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SGPP1 SLC8A1 CHPT1 EDNRB

1.81e-04196644142fd80ff74979cc2f9088fc3fcbfed374afb973
ToppCellBronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC8A1 FPR3 HRH2 TMEM86A

1.81e-041966448862964090f9a679a548103bfbb12e91295aae62
ComputationalGenes in the cancer module 146.

CXCR5 ADRA2B FPR3 HRH1 SSTR2 EDNRB

6.83e-07102346MODULE_146
ComputationalGenes in the cancer module 27.

GHR CXCR5 GABRE ADRA2B GLRA2 GLRA3 HRH1 BDKRB1 EDNRB

1.07e-06355349MODULE_27
ComputationalNeurotransmitter (GABA) receptor.

GLRA2 GLRB GLRA3

1.28e-0515343MODULE_215
ComputationalMembranal receptors.

SLC6A1 GHR CXCR5 GABRE ADRA2B GLRA2 CD53 SSTR2 EDNRB

2.29e-05517349MODULE_64
ComputationalIon channels.

GLRA2 GLRB GLRA3

8.03e-0527343MODULE_214
ComputationalGenes in the cancer module 288.

CXCR5 BDKRB1 EDNRB

2.09e-0437343MODULE_288
ComputationalGenes in the cancer module 289.

CXCR5 ADRA2B BDKRB1 EDNRB

5.99e-04124344MODULE_289
ComputationalGenes in the cancer module 396.

GLRA2 GLRB

6.28e-0412342MODULE_396
ComputationalAcetylCholine receptors.

GLRA2 GLRA3

8.63e-0414342MODULE_328
ComputationalGenes in the cancer module 267.

GLRA2 GLRA3

9.94e-0415342MODULE_267
ComputationalGenes in the cancer module 141.

GLRA2 GLRB

1.13e-0316342MODULE_141
ComputationalIon channels.

GABRE GLRA2 GLRA3

1.37e-0370343MODULE_316
ComputationalVesicular transport / synapse genes.

GABRE GLRA2 GLRB

2.16e-0382343MODULE_274
ComputationalGPCR signaling pathways (immune and neuro).

CXCR5 ADRA2B EDNRB

2.82e-0390343MODULE_375
ComputationalGenes in the cancer module 367.

BDKRB1 EDNRB

3.74e-0329342MODULE_367
ComputationalCaner module 265: IL receptors.

GHR CXCR5

3.74e-0329342MODULE_265
ComputationalGenes in the cancer module 134.

CXCR5 EDNRB

4.00e-0330342MODULE_134
Drugxylometazoline

ADRA1D ADRA2B ADRA2C SLC22A2

1.97e-097644ctd:C009695
DrugDoxepin

ADRA1D ADRA2B ADRA2C HRH1 HRH2

2.25e-0920645DB01142
DrugOxymetazoline

ADRA1D ADRA2B ADRA2C SLC22A2

3.94e-098644ctd:D010109
Drugiso-THAZ

GLRA2 GLRB GLRA3

8.46e-084643CID003047783
Drugprotostrychnine

GLRA2 GLRB GLRA3

8.46e-084643CID005320746
Drug7-nitroindoline

GLRA2 GLRB GLRA3

8.46e-084643CID013566747
Drug2-(phosphonomethyl)phenylalanine

GLRA2 GLRB GLRA3

8.46e-084643CID000383689
DrugSC-49648

GLRA2 GLRB GLRA3

8.46e-084643CID000195696
Drugakuammiline

GLRA2 GLRB GLRA3

8.46e-084643CID005367018
DrugNSC381080

GLRA2 GLRB GLRA3

8.46e-084643CID000165497
DrugN-methyl-THIP

GLRA2 GLRB GLRA3

8.46e-084643CID000134373
DrugSC-48981

GLRA2 GLRB GLRA3

8.46e-084643CID000126573
DrugSC-50132

GLRA2 GLRB GLRA3

8.46e-084643CID000195719
DrugSR 42641

GLRA2 GLRB GLRA3

8.46e-084643CID000129049
Drugazetidine-3-carboxylic acid

GLRA2 GLRB GLRA3

2.11e-075643CID000093192
DrugLindane

GLRA2 GLRB GLRA3

2.11e-075643DB00431
DrugCao C

GLRA2 GLRB GLRA3

2.11e-075643CID000166617
Drugoxanilide

GLRA2 GLRB GLRA3

2.11e-075643CID000069288
Drugiso-THAO

GLRA2 GLRB GLRA3

2.11e-075643CID000127199
DrugALX1393

GLRA2 GLRB GLRA3

2.11e-075643CID016078939
Drugpleiocarpamine

GLRA2 GLRB GLRA3

2.11e-075643CID000558637
Drugmafoprazine

GLRA2 GLRB GLRA3

2.11e-075643CID000071241
Druggevotroline

GLRA2 GLRB GLRA3

2.11e-075643CID000060546
DrugMethotrimeprazine

ADRA1D ADRA2B ADRA2C HRH1

2.13e-0719644DB01403
Drugdi-Z

SLC6A1 GLRA2 GLRB GLRA3

2.66e-0720644CID000656933
DrugXylometazoline

ADRA1D ADRA2B ADRA2C

4.21e-076643DB06694
DrugTHAZ

GLRA2 GLRB GLRA3

4.21e-076643CID000171289
DrugmV GABA

GLRA2 GLRB GLRA3

4.21e-076643CID000128435
Drugcaged glycine

GLRA2 GLRB GLRA3

4.21e-076643CID000192642
Drugbrometone

GLRA2 GLRB GLRA3

4.21e-076643CID000006424
Drugminaxolone

GLRA2 GLRB GLRA3

4.21e-076643CID000071960
Drugthiomuscimol

GLRA2 GLRB GLRA3

4.21e-076643CID000005448
Drugthio-THIP

GLRA2 GLRB GLRA3

4.21e-076643CID000656720
DrugAC1L90PQ

GLRA2 GLRB GLRA3

4.21e-076643CID000436036
Drugurethane

ADRA1D ADRA2B GLRA2 GLRB GLRA3 HRH1 SSTR2

4.77e-07169647CID000005641
Drugalpha-EMTBL

GLRA2 GLRB GLRA3

7.35e-077643CID000128423
DrugCID189778

GLRA2 GLRB GLRA3

7.35e-077643CID000189778
Drugpropyl methanethiosulfonate

GLRA2 GLRB GLRA3

7.35e-077643CID000529387
Drugthiocolchicoside

GLRA2 GLRB GLRA3

7.35e-077643CID000072067
DrugL-serinamide

GLRA2 GLRB GLRA3

7.35e-077643CID000101138
DrugBoc-glycine

GLRA2 GLRB GLRA3

7.35e-077643CID000078288
DrugPK 8165

GLRA2 GLRB GLRA3

7.35e-077643CID000071219
DrugQuetiapine

ADRA1D ADRA2B ADRA2C HRH1

8.10e-0726644DB01224
Drugpitrazepin

ADRA1D GLRA2 GLRB GLRA3

9.49e-0727644CID000146222
DrugWT702

GLRA2 GLRB GLRA3

1.17e-068643CID000089643
Drugisostrychnine

GLRA2 GLRB GLRA3

1.17e-068643CID000264626
DrugAtonik

GLRA2 GLRB GLRA3

1.76e-069643CID000069471
Drugnortropanol

GLRA2 GLRB GLRA3

1.76e-069643CID000068147
DrugAC1NSJX8

GLRA2 GLRB GLRA3

1.76e-069643CID005311059
DrugNSC129536

GLRA2 GLRB GLRA3

1.76e-069643CID000004815
DrugSR 57227A

GLRA2 GLRB GLRA3

1.76e-069643CID000131746
DrugDCQX

GLRA2 GLRB GLRA3

1.76e-069643CID000001845
DrugNorepinephrine

ADRA1D ADRA2B ADRA2C

2.51e-0610643DB00368
DrugDroxidopa

ADRA1D ADRA2B ADRA2C

2.51e-0610643DB06262
DrugTHBA

GLRA2 GLRB GLRA3

2.51e-0610643CID000130993
Drugtetradotoxin

SLC6A1 GABRE ADRA1D ADRA2B GLRA2 GLRB GLRA3 HRH1 EDNRB

2.97e-06428649CID000020382
Drugepinastine

ADRA1D ADRA2B HRH1 HRH2

3.13e-0636644CID000003241
Drugpentobarbital

GABRE ADRA1D ADRA2B GLRA2 GLRB GLRA3 XK

3.13e-06224647CID000004737
Drugip 0

GLRA2 GLRB GLRA3

3.44e-0611643CID000006943
DrugCabergoline-d5

GHR ADRA1D ADRA2B HRH1 SSTR2

3.67e-0683645CID000002512
DrugAC1L1B1W

SLC6A1 GABRE GLRA2 GLRB GLRA3

3.89e-0684645CID000001248
Drugcolchicoside

GLRA2 GLRB GLRA3

4.58e-0612643CID000092763
Drug5 beta-alphaxalone

GABRE GLRA2 GLRB GLRA3

5.86e-0642644CID000068930
DrugABPH

GLRA2 GLRB GLRA3

7.54e-0614643CID000092377
Drugquinoxaline-2,3-dione

GLRA2 GLRB GLRA3

7.54e-0614643CID011469229
DrugRisperidone

ADRA2B ADRA2C HRH1

7.54e-0614643DB00734
Drugisoguvacine

SLC6A1 GLRA2 GLRB GLRA3

7.76e-0645644CID000003765
DrugNorepinephrine

SLC8A1 ADRA1D ADRA2B ADRA2C SLC22A2 EDNRB

8.59e-06171646ctd:D009638
DrugCalcium

GHR CXCR5 PROKR1 SLC8A1 ADRA1D ADRA2B ADRA2C HRH1 BDKRB1

9.31e-06493649ctd:D002118
DrugACEA-1011

GLRA2 GLRB GLRA3

9.41e-0615643CID000127872
Drugmilacemide

GLRA2 GLRB GLRA3

9.41e-0615643CID000053568
DrugLY233536

GLRA2 GLRB GLRA3

1.16e-0516643CID000126239
DrugChlorpheniramine

SLC22A2 HRH1 HRH2

1.16e-0516643ctd:D002744
Drug7-Cl-Thio-Kyna

GLRA2 GLRB GLRA3

1.40e-0517643CID003035668
DrugDiphenhydramine

SLC22A2 HRH1 HRH2

1.40e-0517643ctd:D004155
DrugPaliperidone

ADRA2B ADRA2C HRH1

1.40e-0517643DB01267
DrugPergolide

ADRA1D ADRA2B ADRA2C

1.40e-0517643DB01186
Drugzatosetron

GLRA2 GLRB GLRA3

1.40e-0517643CID000060763
Drugamphetamine

ADRA1D ADRA2B GLRA2 GLRB MC4R GLRA3 TAAR5

1.48e-05284647CID000003007
DrugBromocriptine

ADRA1D ADRA2B ADRA2C

1.68e-0518643DB01200
DrugMNQX

GLRA2 GLRB GLRA3

1.68e-0518643CID000130818
DrugAC1L1CMQ

GLRA2 GLRB GLRA3

1.99e-0519643CID000001968
DrugPNU-120596

GLRA2 GLRB GLRA3

1.99e-0519643CID000311434
Drugnipecotic acid

SLC6A1 GLRA2 GLRB GLRA3

2.01e-0557644CID000004498
Drugwortmannin; Up 200; 0.01uM; ssMCF7; HG-U133A

GABRE ADRA2B REEP1 GLRA2 OR52A1 TMEM63A

2.09e-05200646404_UP
Drug2-hydroxysaclofen

GLRA2 GLRB GLRA3 SSTR2

2.30e-0559644CID000001564
DrugSR 95531

SLC6A1 GLRA2 GLRB GLRA3

2.30e-0559644CID000005275
DrugClonidine

ADRA2B ADRA2C

2.33e-053642DB00575
DrugBrimonidine

ADRA2B ADRA2C

2.33e-053642DB00484
Drugcyanotriphenylborate

GLRA2 GLRB

2.33e-053642CID000151925
Drug7-chloro-4-quinolinol

GLRA2 GLRB

2.33e-053642CID000066593
DrugTizanidine

ADRA2B ADRA2C

2.33e-053642DB00697
Drugpropanethiol

GLRA2 GLRB GLRA3

2.33e-0520643CID000007848
Drugethyltrimethylammonium

GLRA2 GLRB GLRA3

2.72e-0521643CID000033993
Drugmeproadifen

GLRA2 GLRB GLRA3

2.72e-0521643CID000189752
DrugR 5135

GLRA2 GLRB GLRA3

2.72e-0521643CID000119544
DrugPrazosin

SLC8A1 ADRA1D ADRA2C SLC22A2

2.99e-0563644ctd:D011224
DrugZ-Gly

GLRA2 GLRB GLRA3

3.14e-0522643CID000014349
Drugmuscimol

SLC6A1 GABRE GLRA2 GLRB GLRA3

3.15e-05129645CID000004266
Drugpentylenetetrazol

SLC6A1 GABRE GLRA2 GLRB GLRA3

3.27e-05130645CID000005917
Diseaselifestyle measurement, alcohol consumption measurement

SLC6A1 ADRA1D CD53 HRH1 DENND1A

2.93e-06115575EFO_0007878, EFO_0010724
DiseasePain, Migratory

PROKR1 HRH1 BDKRB1

1.18e-0449573C0751407
DiseaseSuffering, Physical

PROKR1 HRH1 BDKRB1

1.18e-0449573C0751408
DiseasePain, Crushing

PROKR1 HRH1 BDKRB1

1.18e-0449573C0458259
DiseasePain, Splitting

PROKR1 HRH1 BDKRB1

1.18e-0449573C0458257
DiseasePain

PROKR1 HRH1 BDKRB1

1.18e-0449573C0030193
DiseaseRadiating pain

PROKR1 HRH1 BDKRB1

1.18e-0449573C0234254
DiseasePain, Burning

PROKR1 HRH1 BDKRB1

1.18e-0449573C0234230
DiseaseAche

PROKR1 HRH1 BDKRB1

1.18e-0449573C0234238
DiseaseWithdrawal Symptoms

SLC6A1 HRH1 HRH2

1.96e-0458573C0087169
DiseaseDrug Withdrawal Symptoms

SLC6A1 HRH1 HRH2

1.96e-0458573C0086189
DiseaseSubstance Withdrawal Syndrome

SLC6A1 HRH1 HRH2

1.96e-0458573C0038587
Diseasedecanoylcarnitine measurement

SLC6A1 HRH1

2.39e-0412572EFO_0021039
Diseasepipecolate measurement

SLC6A1 LAPTM4A

2.82e-0413572EFO_0021006
Diseasenervousness

MC4R DENND1A

4.32e-0416572NCIT_C74532
Diseasesensorineural hearing loss (implicated_via_orthology)

SLC7A8 EDNRB

6.14e-0419572DOID:10003 (implicated_via_orthology)
DiseaseVisual seizure

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0270824
DiseaseEpileptic drop attack

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0270846
DiseaseGeneralized seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0234533
DiseaseClonic Seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0234535
DiseaseVertiginous seizure

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0422855
DiseaseGustatory seizure

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0422854
DiseaseSeizures, Somatosensory

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0422850
DiseaseOlfactory seizure

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0422853
DiseaseSeizures, Auditory

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0422852
DiseaseGeneralized Absence Seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C4505436
DiseaseConvulsive Seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0751494
DiseaseSeizures, Sensory

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0751496
DiseaseJacksonian Seizure

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0022333
DiseaseNon-epileptic convulsion

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0751056
DiseaseAtonic Absence Seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0751123
DiseaseComplex partial seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0149958
DiseaseSingle Seizure

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C0751110
DiseaseEpileptic Seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C4317109
DiseaseNonepileptic Seizures

SLC6A1 SLC8A1 SSTR2

9.96e-04101573C3495874
DiseaseTonic Seizures

SLC6A1 SLC8A1 SSTR2

1.02e-03102573C0270844
DiseaseAbsence Seizures

SLC6A1 SLC8A1 SSTR2

1.02e-03102573C4316903
DiseaseConvulsions

SLC6A1 SLC8A1 SSTR2

1.02e-03102573C4048158
DiseaseSeizures, Focal

SLC6A1 SLC8A1 SSTR2

1.08e-03104573C0751495
DiseaseMyoclonic Seizures

SLC6A1 SLC8A1 SSTR2

1.08e-03104573C4317123
DiseaseTonic - clonic seizures

SLC6A1 SLC8A1 SSTR2

1.08e-03104573C0494475
Diseasesensory perception of smell

ADRA1D TAAR5

1.44e-0329572GO_0007608
Diseaseblood vanadium measurement

OR4K1 HRH2

1.54e-0330572EFO_0021533
Diseasehypertension (is_implicated_in)

SLC8A1 ADRA2B BDKRB1

1.67e-03121573DOID:10763 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
CFRWVLTFFFSVFYL

nan

121

Q8N814
VVAFLVCWAPYHFFA

BDKRB1

256

P46663
VCWAPYHFFAFLEFL

BDKRB1

261

P46663
YVLFFFNLLFWICGC

CD53

11

P19397
SIFFLCWSPYHIVIF

CXCR5

266

P32302
NNWFILSFCIFLPFF

ADAM18

686

Q9Y3Q7
FVLCWFPFFFSYSLY

ADRA2C

391

P18825
ALWAAFLASCFFPYR

GRAMD4

341

Q6IC98
VIGVFVLCWFPFFFS

ADRA2B

376

P18089
VLCWFPFFFSYSLGA

ADRA2B

381

P18089
WLFSFYFCLPLAITA

EDNRB

276

P24530
IPLLTWSFICYFFFQ

AADACL3

241

Q5VUY0
FPLAFLIFNIFYWVI

GLRA3

436

O75311
FPIIYLLFWAFLLVF

SLC7A8

426

Q9UHI5
PDLFKFPFFEAICWF

KDM7A

391

Q6ZMT4
LAFICCWSPYFLFDI

NPSR1

281

Q6W5P4
CWSPYFLFDILDNFN

NPSR1

286

Q6W5P4
VGWLIPFFCYRLFDF

LAPTM4A

106

Q15012
SVILFCVFFWIPFVY

LMBRD1

106

Q9NUN5
RDCLWKFFFPPDYQV

KIAA1109

351

Q2LD37
VVASFFICWFPYELI

FPR3

246

P25089
IFWFNVPEIYFDSCL

OR52A1

86

Q9UKL2
LLFFGPCVFIYAWPF

OR4F5

241

Q8NH21
VVILFFGPCIYFYIW

OR4K1

246

Q8NGD4
GAFIICWFPYFTAFV

HRH2

241

P25021
YPWECFVFCLIIFGT

PEDS1

166

A5PLL7
WIIPFFCYQIFDFAL

LAPTM4B

191

Q86VI4
WVLGCTPFIALAYFF

MFSD2B

116

A6NFX1
TFFFFNVLYWLVCLN

GABRE

491

P78334
FPFCFLFFNVIYWSI

GLRB

481

P48167
LLFFGPCVFIYAWPF

OR4F17

241

Q8NGA8
ALAAPILCLFWLYFF

TMEM63A

671

O94886
YFIEFCSAPFWGVVA

MFSD6

111

Q6ZSS7
FQLWIAFPFCATYAV

OR52R1

26

Q8NGF1
LIYWQLLALFFLPFC

C1QTNF3

6

Q9BXJ4
CLFYWALYFNPIINI

BFAR

421

Q9NZS9
DFANCVFPFWYRRLI

BSPH1

86

Q075Z2
QFTCEEDFYFPWLLI

GHR

256

P10912
PFWIGPFQAFFCIYD

CYP4X1

81

Q8N118
FPLAFLIFNIFYWIT

GLRA2

426

P23416
VCWAPFFLHLIFYIS

MC4R

256

P32245
CFCILSYLPWFEVFY

DENND1A

96

Q8TEH3
MAAFILCWIPYFIFF

HRH1

421

P35367
LCWIPYFIFFMVIAF

HRH1

426

P35367
LPNFFFLLYYWCIPE

SLC22A2

271

O15244
IFWYDLRSISFPACF

OR56A1

91

Q8NGH5
LLFFGPCVFIYAWPF

OR4F4

241

Q96R69
ANSLSPFVFWLLYCF

GPR137B

106

O60478
PFVFWLLYCFPVCLQ

GPR137B

111

O60478
VFDIFIWFAYFNSAC

TAAR5

286

O14804
LFLVFFECVSISWFY

SLC6A1

461

P30531
FFCFVWFLANLSYQE

SLC35F5

246

Q8WV83
FYFQPWAQEAVCRYF

SMARCD1

481

Q96GM5
LFPWFCFCFQRAFKS

TBC1D21

236

Q8IYX1
VLRFFLEYQWFVDFA

TMEM161A

96

Q9NX61
VWLCLLCYFAFPFQL

SLC46A3

116

Q7Z3Q1
ELFYILFFPFWIWNL

SGPP1

141

Q9BX95
AETFTDIFLCWFPFY

REEP1

51

Q9H902
DIFLCWFPFYYELKI

REEP1

56

Q9H902
VVAVFIFCWLPFYIF

SSTR2

261

P30874
IFCWLPFYIFNVSSV

SSTR2

266

P30874
VFVLCWFPFFFVLPL

ADRA1D

356

P25100
MCFDEAFPQFFIVYW

AQP11

226

Q8NBQ7
YPDWFFFCSFIGMFV

CHPT1

156

Q8WUD6
CWAPFYGFTIVRDFF

PROKR1

296

Q8TCW9
VPFFKATCVYFVLWL

TMEM86A

16

Q8N2M4
CLKLVNYSFFFWLPF

SLC37A3

301

Q8NCC5
PFSEVLAYFTFCLWI

TEX261

121

Q6UWH6
LAYFTFCLWIIPFAF

TEX261

126

Q6UWH6
PIFWIFPYFFESRIC

ZCCHC4

311

Q9H5U6
SAVWYLIFFCPLDLF

TMEM38A

91

Q9H6F2
ILINFFSFFLYPWIL

XK

241

P51811
FACKFSEPVYAAFWL

TRIM16L

306

Q309B1
LLTFFFFPICVVFAW

SLC8A1

236

P32418