Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	postsynapse	CACNA1E KCNA2 KCNA3 GOPC MYO5B SNX6 SRGAP3 ADGRB3 TSC2 EPB41L3 RAB3A KIF17 EPB41L1	1.22e-04	1018	80	13	GO:0098794
Domain	FERM_M	PTPN21 EPB41L3 EPB41L1 FERMT3	4.44e-05	46	80	4	PF00373
Domain	PX	SH3PXD2B SNX6 PIK3C2B SNX11	5.71e-05	49	80	4	PF00787
Domain	-	PTPN21 EPB41L3 EPB41L1 FERMT3	5.71e-05	49	80	4	1.20.80.10
Domain	FERM_central	PTPN21 EPB41L3 EPB41L1 FERMT3	5.71e-05	49	80	4	IPR019748
Domain	FERM_1	PTPN21 EPB41L3 EPB41L1 FERMT3	6.19e-05	50	80	4	PS00660
Domain	FERM_2	PTPN21 EPB41L3 EPB41L1 FERMT3	6.19e-05	50	80	4	PS00661
Domain	FERM_3	PTPN21 EPB41L3 EPB41L1 FERMT3	6.19e-05	50	80	4	PS50057
Domain	PX	SH3PXD2B SNX6 PIK3C2B SNX11	6.19e-05	50	80	4	PS50195
Domain	Band_41_domain	PTPN21 EPB41L3 EPB41L1 FERMT3	6.19e-05	50	80	4	IPR019749
Domain	B41	PTPN21 EPB41L3 EPB41L1 FERMT3	6.19e-05	50	80	4	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PTPN21 EPB41L3 EPB41L1 FERMT3	6.19e-05	50	80	4	IPR014352
Domain	-	SH3PXD2B SNX6 PIK3C2B SNX11	6.69e-05	51	80	4	3.30.1520.10
Domain	Phox	SH3PXD2B SNX6 PIK3C2B SNX11	7.23e-05	52	80	4	IPR001683
Domain	Band_4.1_C	EPB41L3 EPB41L1	1.08e-04	4	80	2	IPR008379
Domain	4_1_CTD	EPB41L3 EPB41L1	1.08e-04	4	80	2	PF05902
Domain	SAB_dom	EPB41L3 EPB41L1	1.08e-04	4	80	2	IPR007477
Domain	SAB	EPB41L3 EPB41L1	1.08e-04	4	80	2	PF04382
Domain	FERM_CS	PTPN21 EPB41L3 EPB41L1	1.44e-04	24	80	3	IPR019747
Domain	FERM_C	PTPN21 EPB41L3 EPB41L1	1.83e-04	26	80	3	PF09380
Domain	FERM_C	PTPN21 EPB41L3 EPB41L1	2.06e-04	27	80	3	SM01196
Domain	FERM_PH-like_C	PTPN21 EPB41L3 EPB41L1	2.06e-04	27	80	3	IPR018980
Domain	DCX	RP1L1 DCLK2	3.75e-04	7	80	2	PF03607
Domain	FERM_N	PTPN21 EPB41L3 EPB41L1	3.76e-04	33	80	3	PF09379
Domain	FERM_N	PTPN21 EPB41L3 EPB41L1	3.76e-04	33	80	3	IPR018979
Domain	K_chnl_volt-dep_Kv1	KCNA2 KCNA3	4.99e-04	8	80	2	IPR003972
Domain	DC	RP1L1 DCLK2	4.99e-04	8	80	2	PS50309
Domain	Doublecortin_dom	RP1L1 DCLK2	4.99e-04	8	80	2	IPR003533
Domain	PX	SH3PXD2B PIK3C2B SNX11	8.83e-04	44	80	3	SM00312
Domain	FERM_domain	PTPN21 EPB41L3 EPB41L1	1.21e-03	49	80	3	IPR000299
Domain	FERM-adjacent	EPB41L3 EPB41L1	1.37e-03	13	80	2	IPR014847
Domain	FA	EPB41L3 EPB41L1	1.37e-03	13	80	2	SM01195
Domain	FA	EPB41L3 EPB41L1	1.37e-03	13	80	2	PF08736
Domain	Channel_four-helix_dom	CACNA1E KCNA2 KCNA3	1.87e-03	57	80	3	IPR027359
Domain	-	CACNA1E KCNA2 KCNA3	1.87e-03	57	80	3	1.20.120.350
Domain	EGF	HMCN1 LRP6 LTBP2 CUBN	2.10e-03	126	80	4	PF00008
Domain	PDEase	PDE4C PDE4D	2.96e-03	19	80	2	IPR023088
Domain	ARM-type_fold	PIK3C2B RPTOR HEATR9 TSC2 FRYL CWC22	3.33e-03	339	80	6	IPR016024
Domain	Ez/rad/moesin-like	EPB41L3 EPB41L1	3.61e-03	21	80	2	IPR000798
Domain	PDEase_I	PDE4C PDE4D	3.61e-03	21	80	2	PF00233
Domain	PDEASE_I	PDE4C PDE4D	3.61e-03	21	80	2	PS00126
Domain	PDEase_CS	PDE4C PDE4D	3.61e-03	21	80	2	IPR023174
Domain	FCH	SRGAP3 NOSTRIN	3.96e-03	22	80	2	PF00611
Domain	-	PDE4C PDE4D	3.96e-03	22	80	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4C PDE4D	4.32e-03	23	80	2	IPR002073
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SH3PXD2B TCERG1 PIK3C2B N4BP2 RPTOR NHS TSC2 BRCC3 FRYL DCLK2 PTPN21 EPB41L3 OBI1 EPB41L1 TNS3	1.27e-09	861	81	15	36931259
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E SH3PXD2B KCNA2 KCNA3 UBR5 SRGAP3 N4BP2 RPTOR ADGRB3 TSC2 EPB41L3 RAB3A EPB41L1 LRRFIP2 FERMT3	5.74e-09	963	81	15	28671696
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1E KCNA2 SRGAP3 RPTOR ADGRB3 EPB41L3 RAB3A EPB41L1	1.55e-06	347	81	8	17114649
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	KCNA2 KCNA3 UBR5 ADGRB3 EPB41L3 RAB3A EPB41L1	2.07e-06	251	81	7	27507650
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CACNA1E PDE4D UBR5 SRGAP3 EPB41L3 RAB3A EPB41L1	4.35e-06	281	81	7	28706196
Pubmed	Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.	PDE4C RAB3A	5.36e-06	2	81	2	10574328
Pubmed	Expression and chromosomal localization of a lymphocyte K+ channel gene.	KCNA2 KCNA3	5.36e-06	2	81	2	2251283
Pubmed	SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.	KMT5C TNS3	5.36e-06	2	81	2	25814362
Pubmed	Organization and annotation of the Xcat critical region: elimination of seven positional candidate genes.	NHS REPS2	5.36e-06	2	81	2	15081118
Pubmed	ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.	RPTOR ZFP91	5.36e-06	2	81	2	34403361
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	PDE4D KCNA2 KCNA3	6.67e-06	16	81	3	28283561
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CACNA1E BMP2K UBR5 SRGAP3 RPTOR MAP3K13 REPS2 EPB41L1	7.48e-06	430	81	8	32581705
Pubmed	HDAC5 promotes optic nerve regeneration by activating the mTOR pathway.	RPTOR TSC2	1.60e-05	3	81	2	30910408
Pubmed	The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.	RPTOR TSC2	1.60e-05	3	81	2	20616807
Pubmed	Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population.	RPTOR TSC2	1.60e-05	3	81	2	37493735
Pubmed	Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.	RPTOR TSC2	1.60e-05	3	81	2	23966835
Pubmed	TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.	SHH TSC2	1.60e-05	3	81	2	29396625
Pubmed	A family of three mouse potassium channel genes with intronless coding regions.	KCNA2 KCNA3	1.60e-05	3	81	2	2305265
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4C PDE4D	3.20e-05	4	81	2	9371714
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4C PDE4D	3.20e-05	4	81	2	24732776
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4C PDE4D	3.20e-05	4	81	2	34943270
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4C PDE4D	3.20e-05	4	81	2	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4C PDE4D	3.20e-05	4	81	2	8413254
Pubmed	KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.	KCNA2 KCNA3	3.20e-05	4	81	2	12944270
Pubmed	Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.	PDE4D SHH	3.20e-05	4	81	2	26371509
Pubmed	Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.	SHH TSC2	3.20e-05	4	81	2	22840514
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4C PDE4D	3.20e-05	4	81	2	22946044
Pubmed	Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure.	EPB41L3 EPB41L1	3.20e-05	4	81	2	15834631
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4C PDE4D	3.20e-05	4	81	2	33609559
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE4C PDE4D PIK3C2B	3.42e-05	27	81	3	11156964
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 SH3PXD2B IMPDH1 PIK3C2B RPTOR KMT5C TSC2 FRYL SNX11 ADCY7 PLXNA1	5.03e-05	1105	81	11	35748872
Pubmed	Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein.	EPB41L3 EPB41L1	5.33e-05	5	81	2	12574408
Pubmed	Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.	RPTOR TSC2	5.33e-05	5	81	2	23142078
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4C PDE4D	5.33e-05	5	81	2	33944911
Pubmed	AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.	RPTOR TSC2	5.33e-05	5	81	2	32912901
Pubmed	Band 4.1 proteins regulate integrin-dependent cell spreading.	EPB41L3 EPB41L1	5.33e-05	5	81	2	22982319
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4C PDE4D	5.33e-05	5	81	2	8586960
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNA2 KCNA3	5.33e-05	5	81	2	2333511
Pubmed	Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.	KCNA2 KCNA3	5.33e-05	5	81	2	21233214
Pubmed	The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.	KCNA2 EPB41L3	5.33e-05	5	81	2	21632923
Pubmed	Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.	RPTOR TSC2	5.33e-05	5	81	2	19593385
Pubmed	Subunit composition of Kv1 channels in human CNS.	KCNA2 KCNA3	5.33e-05	5	81	2	10428084
Pubmed	Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.	UBR5 SHH	7.99e-05	6	81	2	27299863
Pubmed	Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.	KCNA2 KCNA3	7.99e-05	6	81	2	8938729
Pubmed	Physical mapping of potassium channel gene clusters on mouse chromosomes three and six.	KCNA2 KCNA3	7.99e-05	6	81	2	9286706
Pubmed	Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly.	KCNA2 KCNA3	7.99e-05	6	81	2	14686897
Pubmed	Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.	RPTOR TSC2	7.99e-05	6	81	2	35379807
Pubmed	mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.	RPTOR TSC2	7.99e-05	6	81	2	31527310
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4C PDE4D	7.99e-05	6	81	2	18923023
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	DCLK2 EPB41L3 EPB41L1	8.93e-05	37	81	3	27565344
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	HIVEP3 USP37 FANCM CWC22	9.39e-05	101	81	4	10997877
Pubmed	Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.	RPTOR LRP6	1.12e-04	7	81	2	30713111
Pubmed	Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.	KCNA2 KCNA3	1.12e-04	7	81	2	7477295
Pubmed	The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.	RPTOR TSC2	1.12e-04	7	81	2	19047368
Pubmed	Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer.	RPTOR TSC2	1.12e-04	7	81	2	20354165
Pubmed	The metabolic regulator mTORC1 controls terminal myeloid differentiation.	RPTOR TSC2	1.12e-04	7	81	2	28763796
Pubmed	Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.	RPTOR TSC2	1.12e-04	7	81	2	21383064
Pubmed	Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers.	KCNA2 EPB41L3	1.12e-04	7	81	2	12975355
Pubmed	A vertebral skeletal stem cell lineage driving metastasis.	HIVEP3 SHH	1.49e-04	8	81	2	37704733
Pubmed	Structural diversity of band 4.1 superfamily members.	EPB41L3 EPB41L1	1.49e-04	8	81	2	7983158
Pubmed	N-terminal PDZ-binding domain in Kv1 potassium channels.	KCNA2 KCNA3	1.49e-04	8	81	2	12435606
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ZC3H14 TCERG1 RPTOR EPB41L3 OBI1	1.51e-04	215	81	5	35973513
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GOPC PMPCA MYO5B SNX6 LRP6 NHS BRCC3 PTPN21 EPB41L1 TNS3	1.61e-04	1049	81	10	27880917
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PDE4D RPTOR NHS RFC1 EPB41L3 OBI1 EPB41L1	1.75e-04	503	81	7	16964243
Pubmed	Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.	KCNA2 KCNA3	1.91e-04	9	81	2	9488722
Pubmed	An LDL-receptor-related protein mediates Wnt signalling in mice.	SHH LRP6	1.91e-04	9	81	2	11029008
Pubmed	The doublecortin gene family and disorders of neuronal structure.	RP1L1 DCLK2	2.38e-04	10	81	2	20236041
Pubmed	Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.	KCNA2 KCNA3	2.38e-04	10	81	2	1383027
Pubmed	The evolving doublecortin (DCX) superfamily.	RP1L1 DCLK2	2.38e-04	10	81	2	16869982
Pubmed	Reprogramming tumour-associated macrophages to outcompete cancer cells.	FCGR1A RPTOR	2.91e-04	11	81	2	37380769
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	SHH LRP6	2.91e-04	11	81	2	24639464
Pubmed	MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.	RPTOR TSC2	2.91e-04	11	81	2	28059666
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	AP1AR PDE4D IMPDH1 GOPC PMPCA SNX6 UBR5 RPP30 PTPN21	3.16e-04	931	81	9	27432908
Pubmed	Rheb binds and regulates the mTOR kinase.	RPTOR TSC2	3.48e-04	12	81	2	15854902
Pubmed	Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.	SHH LRP6	3.48e-04	12	81	2	27864382
Pubmed	A glycolytic shift in Schwann cells supports injured axons.	RPTOR TSC2	3.48e-04	12	81	2	32807950
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	RPTOR TSC2	4.11e-04	13	81	2	25533187
Pubmed	CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure.	KCNA2 EPB41L3	4.11e-04	13	81	2	15601927
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4C PDE4D	4.11e-04	13	81	2	8009369
Pubmed	Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum.	RPTOR TSC2	4.11e-04	13	81	2	35645731
Pubmed	ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.	RPTOR TSC2	4.11e-04	13	81	2	21795849
Pubmed	gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance.	SHH PLXNA1	4.11e-04	13	81	2	22998873
Pubmed	New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.	EPB41L3 EPB41L1	4.11e-04	13	81	2	16368544
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TCERG1 UBR5 PIK3C2B N4BP2 RPTOR ALKBH5 OBI1	4.50e-04	588	81	7	38580884
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	SH3PXD2B N4BP2 RPTOR KIF17	4.60e-04	153	81	4	10718198
Pubmed	A midline switch of receptor processing regulates commissural axon guidance in vertebrates.	SHH PLXNA1	4.79e-04	14	81	2	20159958
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RPTOR TSC2	4.79e-04	14	81	2	28716898
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	ZC3H14 UBR5 PIK3C2B RPP30 BRCC3 RFC1 USP37	5.27e-04	604	81	7	38803224
Pubmed	Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.	HMX2 REPS2	5.52e-04	15	81	2	22383091
Pubmed	Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.	UBR5 TSC2	6.29e-04	16	81	2	29764992
Pubmed	Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.	TSC2 MAP3K13	7.12e-04	17	81	2	19398581
Pubmed	A large family of endosome-localized proteins related to sorting nexin 1.	SNX6 SNX11	7.12e-04	17	81	2	11485546
Pubmed	Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.	SHH LRP6	7.12e-04	17	81	2	20724449
Pubmed	Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.	SHH LRP6	7.12e-04	17	81	2	19795519
Pubmed	In vivo dual-tagging proteomic approach in studying signaling pathways in immune response.	OBI1 LRRFIP2	7.12e-04	17	81	2	15952741
Pubmed	Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue.	PDE4C KCNA2	7.12e-04	17	81	2	10931824
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	HMCN1 ADGRB3 CUBN	7.28e-04	75	81	3	20637190
Pubmed	Transcriptomic landscape of early hair follicle and epidermal development.	SHH PDZD2	8.00e-04	18	81	2	37318953
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	CACNA1E UGT2A3 ZFP91 TATDN2 LRP6 BRCC3 NOSTRIN CUBN HSD17B2 ADCY7	8.34e-04	1293	81	10	15342556
Pubmed	An integrated genetic map of the pearl locus of mouse chromosome 13.	PDE4C PDE4D	8.93e-04	19	81	2	8828042
Interaction	YWHAH interactions	ZC3H14 SH3PXD2B TCERG1 PIK3C2B RPTOR NHS TSC2 BRCC3 FRYL DCLK2 PTPN21 EPB41L3 SUCO CWC22 EPB41L1 TNS3	3.99e-06	1102	78	16	int:YWHAH
Interaction	YWHAG interactions	KCNA3 TCERG1 PIK3C2B N4BP2 RPTOR NHS TSC2 BRCC3 FRYL DCLK2 PTPN21 USP37 EPB41L3 SUCO CWC22 EPB41L1 TNS3	4.44e-06	1248	78	17	int:YWHAG
Cytoband	14q31.3	ZC3H14 PTPN21	2.37e-04	13	81	2	14q31.3
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN21 EPB41L3 EPB41L1 FERMT3	1.97e-05	50	58	4	1293
GeneFamily	Erythrocyte membrane protein band 4.1\|FERM domain containing	EPB41L3 EPB41L1	6.04e-05	4	58	2	951
GeneFamily	Doublecortin superfamily	RP1L1 DCLK2	4.48e-04	10	58	2	1369
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP3 NOSTRIN	2.45e-03	23	58	2	1288
GeneFamily	Phosphodiesterases	PDE4C PDE4D	2.67e-03	24	58	2	681
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX6 SNX11	3.88e-03	29	58	2	754
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	HIVEP3 CACNA1E PDE4C PDE4D KCNA3 ENOX1 TCERG1 SRGAP3 N4BP2 TATDN2 TSC2 DCLK2 C2CD6 RAB3A PLXNA1 EPB41L1	1.92e-07	1106	80	16	M39071
Coexpression	GSE26488_WT_VS_VP16_TRANSGENIC_HDAC7_KO_DOUBLE_POSITIVE_THYMOCYTE_DN	CACNA1E PDE4D BMP2K SRGAP3 SUCO OBI1	1.38e-05	170	80	6	M8188
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	HIVEP3 SH3PXD2B PDE4D HMCN1 ADGRB3 LTBP2 TNS3	5.64e-08	192	80	7	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D TIMD4 MYO5B UGT2A3 NHS CUBN	8.87e-07	180	80	6	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E TIMD4 MYO5B UGT2A3 NHS CUBN	8.87e-07	180	80	6	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D NHS MAP3K13 CUBN EPB41L3 PDZD2	9.16e-07	181	80	6	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D NHS MAP3K13 CUBN EPB41L3 PDZD2	9.16e-07	181	80	6	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIMD4 MYO5B UGT2A3 NHS MAP3K13 CUBN	1.07e-06	186	80	6	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	MYO5B BMP2K NHS MAP3K13 CUBN EPB41L3	1.11e-06	187	80	6	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D TIMD4 MYO5B UGT2A3 NHS CUBN	1.18e-06	189	80	6	28b502611829e4a24caff2562545c7db97686099
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D TIMD4 MYO5B NHS MAP3K13 CUBN	1.21e-06	190	80	6	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B NHS MAP3K13 CUBN EPB41L1	1.33e-06	193	80	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B NHS MAP3K13 CUBN EPB41L1	1.33e-06	193	80	6	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN9 MYO5B PTPN21 EPB41L3 REPS2 TNS3	1.41e-06	195	80	6	a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B SRGAP3 NHS MAP3K13 EPB41L1	1.41e-06	195	80	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN9 MYO5B PTPN21 EPB41L3 REPS2 TNS3	1.50e-06	197	80	6	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E NHS CUBN EPB41L3 PDZD2	1.43e-05	171	80	5	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E NHS CUBN EPB41L3 PDZD2	1.51e-05	173	80	5	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NHS MAP3K13 CUBN EPB41L3 PDZD2	1.64e-05	176	80	5	1595dbeee336a81e581325d63208ec6262664ee9
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE4C ENOX1 DCLK2 PLXNA1 PDZD2	1.73e-05	178	80	5	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CAPN9 MYO5B PTPN21 REPS2 PDZD2	1.78e-05	179	80	5	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D TIMD4 UGT2A3 NHS CUBN	1.78e-05	179	80	5	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E CUBN EPB41L3 REPS2 PDZD2	1.78e-05	179	80	5	78fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NHS MAP3K13 CUBN EPB41L3 PDZD2	1.83e-05	180	80	5	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	TIMD4 UGT2A3 NHS NOSTRIN CUBN	2.03e-05	184	80	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	CACNA1E NHS CUBN EPB41L3 PDZD2	2.03e-05	184	80	5	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	CAPN9 MYO5B PTPN21 REPS2 PDZD2	2.03e-05	184	80	5	561592edc3083fad41b91811151b442207c65dd9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CAPN9 MYO5B PTPN21 EPB41L3 PDZD2	2.09e-05	185	80	5	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E PDE4D UGT2A3 NHS CUBN	2.09e-05	185	80	5	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HIVEP3 BMP2K SRGAP3 FANCM CWC22	2.14e-05	186	80	5	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NHS MAP3K13 CUBN EPB41L3 PDZD2	2.14e-05	186	80	5	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 NHS REPS2 TNS3 PDZD2	2.14e-05	186	80	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D TIMD4 MYO5B UGT2A3 NHS	2.14e-05	186	80	5	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E NHS CUBN EPB41L3 PDZD2	2.14e-05	186	80	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NHS MAP3K13 CUBN EPB41L3 PDZD2	2.20e-05	187	80	5	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 NHS REPS2 TNS3 PDZD2	2.20e-05	187	80	5	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TIMD4 MYO5B UGT2A3 NHS MAP3K13	2.20e-05	187	80	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDE4D MYO5B NHS CUBN EPB41L1	2.20e-05	187	80	5	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	CAPN9 MYO5B PTPN21 REPS2 PDZD2	2.20e-05	187	80	5	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	TIMD4 MYO5B UGT2A3 NHS CUBN	2.31e-05	189	80	5	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NHS MAP3K13 CUBN EPB41L3 PDZD2	2.43e-05	191	80	5	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NHS MAP3K13 CUBN EPB41L3 PDZD2	2.43e-05	191	80	5	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE4D MYO5B LRP6 MAP3K13 PDZD2	2.43e-05	191	80	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	PDE4D MYO5B LRP6 MAP3K13 PDZD2	2.49e-05	192	80	5	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D NHS CUBN EPB41L3 PDZD2	2.49e-05	192	80	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN1 ADGRB3 DCLK2 NOSTRIN EPB41L3	2.55e-05	193	80	5	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B NHS CUBN EPB41L1	2.62e-05	194	80	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MYO5B NHS MAP3K13 EPB41L1	2.62e-05	194	80	5	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	SH3PXD2B BMP2K EPB41L3 ADCY7 TNS3	2.68e-05	195	80	5	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SH3PXD2B BMP2K EPB41L3 ADCY7 TNS3	2.75e-05	196	80	5	7026c1fc33425e5476063d17c79e4b79356a9e01
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO5B NHS REPS2 EPB41L1 TNS3	2.82e-05	197	80	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	HIVEP3 SH3PXD2B PDE4D HMCN1 LTBP2	2.82e-05	197	80	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MMS22L CFAP54 KIF27 HEATR9 VWA3B	2.96e-05	199	80	5	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	PDE4C LRP6 DMRTA1 PTPN21	1.35e-04	145	80	4	80684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	PDE4C LRP6 DMRTA1 PTPN21	1.35e-04	145	80	4	cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B KCNA3 ADCY7 FERMT3	1.46e-04	148	80	4	bbf4933582b50b3412c805de5ed137107c996236
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B KCNA3 ADCY7 FERMT3	1.46e-04	148	80	4	6543860e3207a7de92a35bb6004be51287582f7a
ToppCell	facs-Pancreas-Exocrine-3m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B KCNA3 ADCY7 FERMT3	1.46e-04	148	80	4	79e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	HIVEP3 BMP2K SRGAP3 FANCM	1.50e-04	149	80	4	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	Children_(3_yrs)-Immune-mast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BMP2K PIK3C2B DCLK2 EPB41L1	1.58e-04	151	80	4	bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IL36RN VWA3B USP37 FERMT3	1.75e-04	155	80	4	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	TIMD4 SRGAP3 NHS EPB41L1	1.79e-04	156	80	4	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HIVEP3 KCNA3 IMPDH1 LTBP2	1.97e-04	160	80	4	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 TIMD4 EPB41L3 PLXNA1	1.97e-04	160	80	4	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B TIMD4 ADCY7 FERMT3	2.02e-04	161	80	4	16f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B TIMD4 ADCY7 FERMT3	2.02e-04	161	80	4	f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B TIMD4 ADCY7 FERMT3	2.02e-04	161	80	4	58a32a1033f379579697bda1bbf047a088e4a34f
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TIMD4 MYO5B NHS	2.07e-04	162	80	4	b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 EPB41L3 ADCY7 PLXNA1	2.12e-04	163	80	4	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 EPB41L3 ADCY7 PLXNA1	2.12e-04	163	80	4	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	metastatic_Brain-Myeloid_cells-pDCs\|metastatic_Brain / Location, Cell class and cell subclass	N4BP2 KMT5C DCLK2 KIF17	2.17e-04	164	80	4	06db4cc064f0765c481ce880207823872c27bfa9
ToppCell	facs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B TIMD4 CUBN EPB41L3	2.22e-04	165	80	4	4f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	ENOX1 NOSTRIN PLXNA1 EPB41L1	2.22e-04	165	80	4	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	facs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3PXD2B TIMD4 CUBN EPB41L3	2.22e-04	165	80	4	3e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TATDN2 LRP6 HSD17B2 USP37	2.27e-04	166	80	4	c8fd241088de27c6e741a5dfee3cd770183b6bcb
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIMD4 EPB41L3 PLXNA1 EPB41L1	2.38e-04	168	80	4	4ae9e9d93bcd6f4d5815e57fd5afa7a3398a0ec1
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIMD4 EPB41L3 PLXNA1 EPB41L1	2.38e-04	168	80	4	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIMD4 EPB41L3 PLXNA1 EPB41L1	2.43e-04	169	80	4	454b92b9b67299a64278c010db033ca5b9d217a0
ToppCell	Ionocyte-iono-1\|World / Class top	RPTOR FANCM RAB3A KIF17	2.43e-04	169	80	4	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 ANXA13 SHH EPB41L3	2.49e-04	170	80	4	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RP1L1 ADGRB3 HMX2 SUCO	2.49e-04	170	80	4	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	10x5'-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	N4BP2 ADGRB3 DCLK2 KIF17	2.49e-04	170	80	4	59cb1262ff319349d42b11afbec2a9035b7b79f2
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 TIMD4 EPB41L3 PLXNA1	2.60e-04	172	80	4	7295bf3ae21a61dd6bcfa0dfb7a37d0f3e8f94ab
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 MYO5B SHH HSD17B2	2.72e-04	174	80	4	e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN9 MYO5B SHH HSD17B2	2.72e-04	174	80	4	ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ENOX1 HMCN1 ADGRB3 NHS	2.72e-04	174	80	4	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	MYO5B PTPN21 EPB41L3 PDZD2	2.72e-04	174	80	4	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 ANXA13 SHH EPB41L3	2.78e-04	175	80	4	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPN9 HIVEP3 RFC1 TNS3	2.84e-04	176	80	4	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|Endothelial_cells / Location, Cell class and cell subclass	AP1AR IL36RN SRGAP3 HSD17B2	2.84e-04	176	80	4	42541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TIMD4 EPB41L3 REPS2 PLXNA1	2.90e-04	177	80	4	26bad614560609d318bfc9c235a698bca4e1c22c
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5B SHH EPB41L3 TNS3	2.90e-04	177	80	4	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	HMCN1 LTBP2 EPB41L1 TNS3	2.96e-04	178	80	4	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1E UGT2A3 NHS CUBN	2.96e-04	178	80	4	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA2 TIMD4 EPB41L3 PLXNA1	2.96e-04	178	80	4	6c1b5087581ca8cea976d89ea6f34088c8fc3668
ToppCell	droplet-Marrow-nan-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP3 CACNA1E BMP2K SRGAP3	3.03e-04	179	80	4	dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCell	Bronchial_Biopsy-Immune-Neutrophils\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	FCGR1A EPB41L3 ADCY7 FERMT3	3.03e-04	179	80	4	8c50e13927c09de05c86cd90dd6f71cee004b0d3
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	MED14OS KCNA3 FANCM ADCY7	3.03e-04	179	80	4	c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAP3K13 CUBN EPB41L3 PDZD2	3.03e-04	179	80	4	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP3 CACNA1E BMP2K SRGAP3	3.03e-04	179	80	4	87a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D ENOX1 ANXA13 NHS	3.03e-04	179	80	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP3 CACNA1E BMP2K SRGAP3	3.09e-04	180	80	4	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
Disease	inflammatory bowel disease (implicated_via_orthology)	EPB41L3 EPB41L1 PDZD2	3.92e-05	25	78	3	DOID:0050589 (implicated_via_orthology)
Disease	skin microbiome measurement	CFAP54 SRGAP3 ADGRB3	1.52e-04	39	78	3	EFO_0801228
Disease	response to trauma exposure	PDE4D DMRTA1 MAP3K13	3.38e-04	51	78	3	EFO_0008483
Disease	Eye Abnormalities	SH3PXD2B SHH	9.14e-04	17	78	2	C0015393
Disease	epilepsy (implicated_via_orthology)	CACNA1E KCNA2 KCNA3 RAB3A	9.32e-04	163	78	4	DOID:1826 (implicated_via_orthology)
Disease	Amphetamine-Related Disorders	PDE4D MYO5B CUBN	1.05e-03	75	78	3	C0236733
Disease	Amphetamine Abuse	PDE4D MYO5B CUBN	1.05e-03	75	78	3	C0236807
Disease	Amphetamine Addiction	PDE4D MYO5B CUBN	1.05e-03	75	78	3	C0236804
Disease	cerebellum white matter volume change measurement, age at assessment	ADGRB3 EPB41L3	1.27e-03	20	78	2	EFO_0008007, EFO_0021498
Disease	brain age measurement	ANXA13 SHH	1.27e-03	20	78	2	EFO_0010602
Disease	sphingomyelin 24:1 measurement	MMS22L PDE4D	1.68e-03	23	78	2	EFO_0010398
Disease	visceral adipose tissue measurement	HIVEP3 ZC3H14 MMS22L PDE4C PIK3C2B RPTOR	1.74e-03	481	78	6	EFO_0004765
Disease	corpus callosum central volume measurement	SHH PDZD2	2.49e-03	28	78	2	EFO_0010296
Disease	hemoglobin A1 measurement	HIVEP3 TIMD4 SRGAP3 RP1L1 DMRTA1 RFC1	2.56e-03	520	78	6	EFO_0007629

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELMSSSKSQEESRRY	CFAP54	331	Q96N23
EFSMERSSENTYKSR	CACNA1E	2036	Q15878
TISMSSLERRKSRYS	ADGRB3	1406	O60242
SMTSRDNYKAGSREA	ALKBH5	16	Q6P6C2
YQKSLSDMVRSDTSG	ANXA13	291	P27216
SDMVRSDTSGDFRKL	ANXA13	296	P27216
MKSQYEVFRSSRLSS	AP1AR	161	Q63HQ0
DRSMSPKGRSEDDSY	ADCY7	531	P51828
AKYSDMSSVYRDRSG	BMP2K	811	Q9NSY1
MASATDSRYGQKESS	RAB3A	1	P20336
DITYEGRQKMTSLSS	GOPC	61	Q9HD26
RPSSSYSLDQDKMTS	OR5W2	261	Q8NH69
FFERSSSKRYTMSRS	EPB41L1	416	Q9H4G0
SSKRYTMSRSLDGAE	EPB41L1	421	Q9H4G0
KSRSASTISKSDYME	KCNA2	446	P16389
YMLTARGGSRSAERK	MED14OS	91	P0DP75
GENDFSIMYSTRKRS	KMT5C	156	Q86Y97
LNRYDKVRSSESLMS	MMS22L	271	Q6ZRQ5
GDTSRMFRRTKSYDS	FANCM	1906	Q8IYD8
SYDSSMESRNRDREK	CWC22	61	Q9HCG8
ITSSTKYTERDGSAM	DCLK2	481	Q8N568
QRESYSGKFTSRRMV	C2CD6	581	Q53TS8
ARKRSSTMGTLRDYA	DSG4	756	Q86SJ6
KLSGREREMDSSASS	KIF27	1271	Q86VH2
FTKSLSRYESMLRTA	PLXNA1	1616	Q9UIW2
AEYSQGKSSLMSDSR	PDZD2	2181	O15018
SDYELSPKAMSRNSS	PDE4C	126	Q08493
DSDYDLSPKSMSRNS	PDE4D	196	Q08499
TRSLSSLREKGMYDV	FRYL	1976	O94915
STFDMKRYLSSSERA	HMX2	166	A2RU54
RTRTSSEASMDAAYL	OBI1	521	Q5W0B1
RKARSNSTLSKSEYM	KCNA3	516	P22001
RMTSVATAKGYTSDL	LRP6	1546	O75581
KSFTFYRRDMGLTSS	IL36RN	96	Q9UBH0
YRRDMGLTSSFESAA	IL36RN	101	Q9UBH0
YDMFKDRSSRLSSLN	LRRFIP2	111	Q9Y608
KITETRTSDSGMYLC	HMCN1	1136	Q96RW7
SLDAMEKSSSSQKRY	IMPDH1	416	P20839
MSESDLTTSGRYRAR	PTPN21	796	Q16825
KSTYDAEMLRDATRG	PIK3C2B	241	O00750
GSPKMSTSSSKSRYR	MAP3K13	571	O43283
AYDGLSSTMSRLART	CUBN	1566	O60494
GMIRDSSYLSSKDSI	DMRTA1	476	Q5VZB9
TYASSDIRLSMRKAE	LTBP2	731	Q14767
MGSKTLRGRNTSSEY	FCGR1A	231	P12314
DKSGTMSTYELRTAL	CAPN9	606	O14815
MERLASYGSSKAAVT	HSD17B2	226	P37059
SGYRMRLGSSTDKKD	ENOX1	196	Q8TC92
ERSSSKRYTMSRSLD	EPB41L3	431	Q9Y2J2
EGLERMLKTYSSTSS	NOSTRIN	321	Q8IVI9
RSVGYTLMNKDSSRS	KIF17	196	Q9P2E2
SRKSRDMEIKNYSSS	OR1L6	31	Q8NGR2
KDSTMRRYTISSALN	RPP30	161	P78346
RDTTMYAVSADSKGL	PMPCA	146	Q10713
GRSTMTVSDAILRYA	SNX11	141	Q9Y5W9
VDITTSDRDRSKYGM	SHH	146	Q15465
AQVGKSSRSRMSDYS	TATDN2	406	Q93075
LLKKGSRSDSSYRMS	NHS	1521	Q6T4R5
RTYSSKRTVNMDYLS	RFC1	986	P35251
LKEMTDARSKYSGTR	TNS3	441	Q68CZ2
FETIDKMRRASSYSS	RPTOR	781	Q8N122
TRSDSKFAYTGTEMR	BRCC3	46	P46736
RYTSEMRSELLGTDS	USE1	116	Q9NZ43
SYSSTSIEEAMKRGE	REPS2	461	Q8NFH8
RSTESVKSAASETYM	SRGAP3	406	O43295
AERKATRMYPESSTS	RP1L1	2336	Q8IWN7
RYKAVDSSSMREDLF	TCERG1	826	O14776
AGMSFSRKSYRLTSD	RNF123	6	Q5XPI4
RKASSDMSASAGYEE	SH3PXD2B	496	A1X283
MAYEKSTDISDVSRS	HEATR9	1	A2RTY3
LSRRSSMESPKSSLY	HIVEP3	491	Q5T1R4
SKGRTMADSSYTSEV	FERMT3	456	Q86UX7
SSYDDMNLKRRTSFP	SUCO	1061	Q9UBS9
SDRMTRSHKSAADDY	SNX6	231	Q9UNH7
AMTDPSRKYLTSSRE	USP37	231	Q86T82
ITDSSYKENAMRLSR	UGT2A3	431	Q6UWM9
SKSYCSGTERVSLMA	ZFP91	516	Q96JP5
MSSLRSSACSERKDG	VWA3B	781	Q502W6
LTKDAFSLGRDRMTS	UHRF1BP1	1046	Q6BDS2
TYDDGAATRLMSTVK	ZC3H14	146	Q6PJT7
TDGMRVTSRKSAKYR	TIMD4	71	Q96H15
MDRRTDAYSRSSSVS	TSC2	1326	P49815
SSIASSASMPYKRRR	UBR5	621	O95071
TGYRKRSSSMADGDN	MYO5B	1636	Q9ULV0
YSKTDTDSSMERVSP	N4BP2	711	Q86UW6