Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

UNCX AHR RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

5.19e-0714122110GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

AHR RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

7.60e-061459219GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ISX ESX1 OTP HMX1

3.12e-04320214GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ISX ESX1 OTP HMX1

3.35e-04326214GO:0001217
GeneOntologyMolecularFunctionK63-linked polyubiquitin modification-dependent protein binding

OTUD7B OTUD7A

3.37e-0426212GO:0070530
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

OTUD7B OTUD7A

1.74e-0359212GO:0031593
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

OTUD7B OTUD7A

6.32e-03114212GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

OTUD7B OTUD7A

7.44e-03124212GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

OTUD7B OTUD7A

9.01e-03137212GO:0019783
GeneOntologyBiologicalProcessprotein deubiquitination involved in ubiquitin-dependent protein catabolic process

OTUD7B OTUD7A

2.75e-058212GO:0071947
GeneOntologyBiologicalProcessprotein K11-linked deubiquitination

OTUD7B OTUD7A

4.42e-0510212GO:0035871
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

AHR ISX ESX1 OTP RFC1 OTUD7B HMX1

5.48e-051053217GO:0000122
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

AHR ISX ESX1 OTP RFC1 OTUD7B HMX1

3.25e-041399217GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

AHR ISX ESX1 OTP RFC1 OTUD7B HMX1

3.45e-041413217GO:1902679
GeneOntologyBiologicalProcessprotein K48-linked deubiquitination

OTUD7B OTUD7A

4.51e-0431212GO:0071108
GeneOntologyBiologicalProcesshypothalamus development

RAX OTP

4.51e-0431212GO:0021854
GeneOntologyBiologicalProcessprotein K63-linked deubiquitination

OTUD7B OTUD7A

4.81e-0432212GO:0070536
GeneOntologyCellularComponentchromatin

UNCX AHR RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

2.94e-0714802010GO:0000785
MousePhenoutricular degeneration

HMX3 HMX2

5.83e-063202MP:0004332
MousePhenoabnormal hypothalamus physiology

OTP HMX3 HMX2

6.38e-0626203MP:0005645
MousePhenovestibular saccular degeneration

HMX3 HMX2

4.07e-057202MP:0004329
MousePhenoabnormal diencephalon morphology

ZDHHC13 RAX OTP HMX3 HMX2

5.07e-05298205MP:0000830
MousePhenoabnormal hypothalamus secretion

HMX3 HMX2

1.27e-0412202MP:0001752
MousePhenoabnormal vertebral pedicle morphology

UNCX EVC

1.27e-0412202MP:0004604
MousePhenoabsent semicircular canals

HMX3 HMX2

1.27e-0412202MP:0000036
MousePhenoabnormal hypothalamic nucleus morphology

RAX OTP

1.50e-0413202MP:0020872
MousePhenodecreased vestibular hair cell number

HMX3 HMX2

2.31e-0416202MP:0004328
MousePhenodecreased circulating growth hormone level

HMX3 HMX2

2.61e-0417202MP:0005120
MousePhenoabnormal vestibular hair cell number

HMX3 HMX2

3.28e-0419202MP:0004326
MousePhenosmall adenohypophysis

HMX3 HMX2

4.83e-0423202MP:0008321
MousePhenoabnormal crista ampullaris morphology

HMX3 HMX2

7.19e-0428202MP:0004249
MousePhenosmall pituitary gland

HMX3 HMX2

8.26e-0430202MP:0005361
MousePhenoabnormal endolymphatic duct morphology

HMX3 HMX2

8.82e-0431202MP:0006011
MousePhenoabnormal pituitary gland morphology

OTP HMX3 HMX2

8.90e-04135203MP:0000633
MousePhenoabnormal semicircular canal ampulla morphology

HMX3 HMX2

9.40e-0432202MP:0008488
DomainHomeobox_CS

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

2.10e-13186219IPR017970
DomainHomeobox

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

1.68e-12234219PF00046
DomainHOMEOBOX_1

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

1.82e-12236219PS00027
DomainHOX

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

1.89e-12237219SM00389
DomainHomeobox_dom

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

2.04e-12239219IPR001356
DomainHOMEOBOX_2

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

2.04e-12239219PS50071
Domain-

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

9.30e-122832191.10.10.60
DomainHomeodomain-like

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

3.88e-11332219IPR009057
DomainCezanne-2

OTUD7B OTUD7A

1.20e-062212IPR033477
DomainZnf_A20

OTUD7B OTUD7A

2.52e-057212IPR002653
DomainZF_A20

OTUD7B OTUD7A

2.52e-057212PS51036
DomainZnF_A20

OTUD7B OTUD7A

2.52e-057212SM00259
Domainzf-A20

OTUD7B OTUD7A

2.52e-057212PF01754
DomainOTU

OTUD7B OTUD7A

9.32e-0513212PF02338
DomainOTU

OTUD7B OTUD7A

1.25e-0415212PS50802
DomainOTU_dom

OTUD7B OTUD7A

1.25e-0415212IPR003323
DomainOAR

RAX OTP

1.25e-0415212PF03826
DomainHomeobox_metazoa

HMX3 HMX1 HMX2

1.35e-0490213IPR020479
DomainOAR

RAX OTP

1.43e-0416212PS50803
DomainOAR_dom

RAX OTP

1.43e-0416212IPR003654
DomainUBA-like

OTUD7B OTUD7A

2.33e-0364212IPR009060
DomainHTH_motif

OTP HMX1

2.70e-0369212IPR000047
PathwayREACTOME_OVARIAN_TUMOR_DOMAIN_PROTEASES

OTUD7B OTUD7A

1.78e-043292MM15290
PathwayREACTOME_OVARIAN_TUMOR_DOMAIN_PROTEASES

OTUD7B OTUD7A

2.65e-043992M27579
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

ISX ESX1 RAX OTP HMX3 HMX1 HMX2

1.39e-1026321720932939
Pubmed

Hmx: an evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila.

HMX3 HMX1 HMX2

1.90e-10321311091080
Pubmed

Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family.

HMX3 HMX1 HMX2

1.90e-1032137647458
Pubmed

A census of human transcription factors: function, expression and evolution.

UNCX RAX2 ISX ESX1 RAX OTP HMX3 HMX1 HMX2

1.20e-0990821919274049
Pubmed

Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene.

HMX3 HMX1 HMX2

1.59e-0892139435283
Pubmed

Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.

RAX OTP HMX3 HMX2

1.29e-077721421525287
Pubmed

Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx.

OTP HMX3 HMX2

2.51e-072121315363417
Pubmed

Molecular (SNP) analyses of overlapping hemizygous deletions of 10q25.3 to 10qter in four patients: evidence for HMX2 and HMX3 as candidate genes in hearing and vestibular function.

HMX3 HMX2

3.47e-07221219253379
Pubmed

Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression.

AHR ISX

3.47e-07221228398627
Pubmed

Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia.

HMX3 HMX2

3.47e-07221233048949
Pubmed

Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities.

HMX3 HMX2

3.47e-07221210543441
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

UNCX ISX ESX1 RAX HMX1 HMX2

6.33e-0754421628473536
Pubmed

Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site.

HMX3 HMX1

1.04e-06321210206974
Pubmed

Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7.

HMX3 HMX2

1.04e-0632129421269
Pubmed

Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development.

HMX3 HMX2

2.08e-0642128970821
Pubmed

QRX, a novel homeobox gene, modulates photoreceptor gene expression.

RAX2 RAX

2.08e-06421215028672
Pubmed

A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development.

HMX3 HMX2

2.08e-0642127510254
Pubmed

Nkx5-1 controls semicircular canal formation in the mouse inner ear.

HMX3 HMX2

2.08e-0642129389661
Pubmed

Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development.

HMX3 HMX2

2.08e-0642128541222
Pubmed

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.

OTUD7B OTUD7A

7.28e-06721218281465
Pubmed

Hmx2 homeobox gene control of murine vestibular morphogenesis.

HMX3 HMX2

1.25e-05921211748138
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

AHR HMX3 HMX1 HMX2

1.44e-0525121429031500
Pubmed

Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area.

OTP HMX3

1.56e-051021226189100
Pubmed

Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.

OTP HMX3

1.90e-051121210433909
Pubmed

Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects.

HMX3 HMX2

2.28e-051221223226461
Pubmed

The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus.

OTP HMX2

2.70e-051321211071765
Pubmed

Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear.

HMX3 HMX2

2.70e-051321216597514
Pubmed

Three-dimensional molecular architecture of mouse organogenesis.

UNCX ISX OTP

2.95e-0510021337524711
Pubmed

Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.

HMX3 HMX2

3.15e-051421223457544
Pubmed

Decoding neuronal composition and ontogeny of individual hypothalamic nuclei.

RAX OTP

3.63e-051521233600763
Pubmed

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.

HMX3 HMX2

3.63e-051521222383091
Pubmed

Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.

ESX1 CALCR

4.15e-051621218163532
Pubmed

The sacral autonomic outflow is sympathetic.

HMX3 HMX2

4.15e-051621227856909
Pubmed

Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus.

HMX3 HMX2

4.70e-051721216900517
Pubmed

Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment.

UNCX HMX3

5.28e-051821221930923
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

AHR RAX OTP HMX3 HMX1

5.39e-0570921522988430
Pubmed

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

OTUD7B OTUD7A

5.90e-051921223827681
Pubmed

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.

RAX OTP

5.90e-051921218697938
Pubmed

Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators.

OTP CALCR

5.90e-051921231420539
Pubmed

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling.

RAX OTP

5.90e-051921226911688
Pubmed

Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.

HMX3 HMX2

5.90e-051921219913004
Pubmed

Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells.

HMX3 HMX2

6.55e-052021216469766
Pubmed

Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons.

OTP HMX2

8.72e-052321229795232
Pubmed

Cascade diversification directs generation of neuronal diversity in the hypothalamus.

RAX OTP

9.51e-052421233887179
Pubmed

Retinoic acid deficiency impairs the vestibular function.

HMX3 HMX2

1.12e-042621223536097
Pubmed

Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus.

RAX OTP

1.21e-042721230063881
Pubmed

The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.

OTP HMX2

1.30e-042821232868762
Pubmed

Specification of jaw identity by the Hand2 transcription factor.

UNCX HMX1

1.30e-042821227329940
Pubmed

LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis.

RAX OTP

1.30e-042821223595746
Pubmed

Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.

HMX3 HMX1

1.30e-042821217698011
Pubmed

OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.

OTUD7B OTUD7A

1.70e-043221233669244
Pubmed

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.

HMX3 HMX2

2.95e-044221226166575
Pubmed

Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.

OTUD7B OTUD7A

4.18e-045021231699778
Cytoband10q26.13

HMX3 HMX2

1.39e-043821210q26.13
CytobandEnsembl 112 genes in cytogenetic band chr10q26

HMX3 HMX2

4.02e-03207212chr10q26
CytobandEnsembl 112 genes in cytogenetic band chr4p16

EVC HMX1

4.60e-03222212chr4p16
GeneFamilyPRD class homeoboxes and pseudogenes

UNCX RAX2 ISX ESX1 RAX OTP

1.74e-1092176521
GeneFamilyNKL subclass homeoboxes and pseudogenes

HMX3 HMX1 HMX2

3.19e-0567173519
GeneFamilyOTU domain containing

OTUD7B OTUD7A

1.12e-0417172669
GeneFamilyAnkyrin repeat domain containing

ZDHHC13 ACAP3

2.13e-02242172403
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

UNCX ESX1 RAX OTP HMX3 HMX1 HMX2 CALCR

2.20e-11272218M1938
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

UNCX ESX1 RAX OTP HMX3 HMX1 HMX2 CALCR

2.93e-11282218MM822
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

UNCX AHR HMX3 HMX1 HMX2 CALCR

2.49e-07350216M1949
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

UNCX RAX OTP HMX1 OTUD7A HMX2 CALCR

2.53e-07591217M2019
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

UNCX AHR HMX3 HMX1 HMX2 CALCR

2.80e-07357216MM828
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3K27ME3

UNCX RAX OTP HMX1 OTUD7A HMX2 CALCR

2.83e-07601217MM866
CoexpressionBENPORATH_EED_TARGETS

AHR ESX1 RAX OTP HMX3 HMX2 CALCR

1.22e-051059217M7617
CoexpressionBENPORATH_PRC2_TARGETS

ESX1 RAX OTP HMX3 HMX2

1.35e-04650215M8448
CoexpressionBENPORATH_ES_WITH_H3K27ME3

ESX1 RAX OTP HMX3 HMX2 CALCR

1.83e-041115216M10371
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))-|Thalamus / BrainAtlas - Mouse McCarroll V32

OTP HMX3 CALCR

1.14e-0594213be1dcfe287f58d608ccdb47cf9c1d12b5e3aa60d
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6|Thalamus / BrainAtlas - Mouse McCarroll V32

OTP HMX3 CALCR

1.14e-0594213576c37fa53fab679f5e8786f5c798e18998186e9
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))|Thalamus / BrainAtlas - Mouse McCarroll V32

OTP HMX3 CALCR

1.14e-059421382e9178c848468497295c4cc59c662b9279208a1
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-2|TCGA-Lung / Sample_Type by Project: Shred V9

HMX3 TTLL4 HMX2

4.35e-05147213457bc1175810f241ed8966b76ed4fc4ef3fb144c
ToppCellCD8+_Memory_T_cell-RSV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

EVC GIN1 OTUD7A

5.39e-051582135ae737757a49fc96bde1e57e02066f9f65654ea1
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

AHR HMX3 HMX2

9.18e-05189213620d30bb6211fff6adab0638d0d994f547167a29
Drugoctogen

HMX3 HMX1 HMX2

1.73e-0626213CID000017596
Drugo-terphenyl

AHR OTP

2.26e-058212CID000006766
Drugbenzanthrone

AHR RAX2

2.60e-0426212ctd:C012768
Drugtamoxifen citrate; Up 200; 1uM; MCF7; HG-U133A

AHR ZDHHC13 TOR1AIP1

7.79e-04199213143_UP
Drugss,ss-carotene

AHR ISX CALCR

8.02e-04201213CID000000573
DrugKN 93

AHR CALCR

8.18e-0446212ctd:C072105
DrugW 7

AHR CALCR

8.91e-0448212ctd:C017967
DrugRa X Peptide

RAX2 RAX

1.30e-0358212CID006444175
DiseaseCongenital small ears

EVC HMX1

3.52e-0441202C0152423
DiseaseOsteoporosis, Senile

ZDHHC13 CALCR

7.80e-0461202C0029459
DiseaseOsteoporosis, Age-Related

ZDHHC13 CALCR

7.80e-0461202C0001787
DiseasePost-Traumatic Osteoporosis

ZDHHC13 CALCR

7.80e-0461202C0751406
DiseaseOsteoporosis

ZDHHC13 CALCR

8.32e-0463202C0029456
Diseaselongitudinal BMI measurement

EVC CALCR

1.40e-0382202EFO_0005937
Diseaseconotruncal heart malformations

AHR CALCR

2.69e-03114202MONDO_0016581
Diseasecreatinine measurement

UNCX AHR EVC TEX11

4.04e-03995204EFO_0004518
Diseasephotoreceptor cell layer thickness measurement

RAX2 RAX

4.47e-03148202EFO_0803370
DiseaseCraniofacial Abnormalities

RAX HMX1

4.96e-03156202C0376634
DiseaseRheumatoid Arthritis

AHR GIN1

6.13e-03174202C0003873

Protein segments in the cluster

PeptideGeneStartEntry
KNNRWTWVQSNARLL

AHR

356

P35869
DRVQVWFQNRRAKWK

ESX1

181

Q8N693
WFQNRRAKWKRNQRV

ESX1

186

Q8N693
WAQFKIQWNQRWGRR

CALCR

406

P30988
FKRASNAFKTWNRRW

ACAP3

276

Q96P50
NAFKTWNRRWFSIQN

ACAP3

281

Q96P50
VQIWFQNQRAKWRKQ

ISX

126

Q2M1V0
VQVWFQNRRAKWRRQ

RAX2

71

Q96IS3
KRRWRWQQTQQNKES

OTUD7B

231

Q6GQQ9
VKIWFQNRRNKWKRQ

HMX3

271

A6NHT5
QVKIWFQNRRNKWKR

HMX1

246

Q9NP08
TQVKTWFQNRRNKWK

HMX2

191

A2RU54
WFQNRRNKWKRQLSA

HMX2

196

A2RU54
LKRRWRWQQTQQNKE

OTUD7A

246

Q8TE49
AWQLGKSNRFRRQQW

EVC

566

P57679
SRVQVWFQNRRAKWK

OTP

146

Q5XKR4
SCANKLLRWLRNWQK

RFC1

606

P35251
LRQRKNWWKDGRFQS

GIN1

371

Q9NXP7
QVWFQNRRAKWRRQE

RAX

181

Q9Y2V3
QPQNASFVKRNRWWL

TOR1AIP1

326

Q5JTV8
RANQKFRLWRWLQKC

ZDHHC13

276

Q8IUH4
RANEAQWFRKTAWNL

TEX11

631

Q8IYF3
PSFQWNVLNRSRRWK

TTLL4

366

Q14679
ESRVQVWFQNRRAKW

UNCX

146

A6NJT0