Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	frizzled binding	FZD7 WNT2 DLG4	1.88e-04	42	53	3	GO:0005109
GeneOntologyMolecularFunction	PDZ domain binding	FZD7 ADRB1 DLG4 FZD2	3.18e-04	123	53	4	GO:0030165
GeneOntologyMolecularFunction	calcium ion binding	TPO PITPNM2 PGS1 USP32 LRP1 NECAB3 NINL PLCD4	7.51e-04	749	53	8	GO:0005509
GeneOntologyMolecularFunction	Wnt receptor activity	FZD7 FZD2	9.16e-04	17	53	2	GO:0042813
GeneOntologyMolecularFunction	adrenergic receptor binding	ADRB1 DLG4	1.84e-03	24	53	2	GO:0031690
GeneOntologyMolecularFunction	protein domain specific binding	FZD7 EZR STRN ADRB1 MOSPD2 SHCBP1 DLG4 FZD2	2.03e-03	875	53	8	GO:0019904
Domain	TRPV5/TRPV6	TRPV6 TRPV5	7.90e-06	2	53	2	IPR008344
Domain	EF-hand_5	USP32 NECAB3 PLCD4	4.75e-05	25	53	3	PF13202
Domain	NUT	NUTM2B NUTM2A	7.86e-05	5	53	2	IPR024310
Domain	NUT_N	NUTM2B NUTM2A	7.86e-05	5	53	2	IPR024309
Domain	NUT	NUTM2B NUTM2A	7.86e-05	5	53	2	PF12881
Domain	TRP_channel	TRPV6 TRPV5	4.27e-04	11	53	2	IPR004729
Domain	Frizzled	FZD7 FZD2	4.27e-04	11	53	2	IPR000539
Domain	Frizzled	FZD7 FZD2	4.27e-04	11	53	2	PF01534
Domain	Frizzled	FZD7 FZD2	4.27e-04	11	53	2	SM01330
Domain	Frizzled/SFRP	FZD7 FZD2	9.24e-04	16	53	2	IPR015526
Domain	EFh	USP32 NECAB3 NINL PLCD4	1.05e-03	158	53	4	SM00054
Domain	FRI	FZD7 FZD2	1.45e-03	20	53	2	SM00063
Domain	EF_Hand_1_Ca_BS	USP32 NECAB3 NINL PLCD4	1.52e-03	175	53	4	IPR018247
Domain	-	FZD7 FZD2	1.60e-03	21	53	2	1.10.2000.10
Domain	Frizzled_dom	FZD7 FZD2	2.10e-03	24	53	2	IPR020067
Domain	FZ	FZD7 FZD2	2.10e-03	24	53	2	PS50038
Domain	Fz	FZD7 FZD2	2.10e-03	24	53	2	PF01392
Domain	EF_HAND_1	USP32 NECAB3 NINL PLCD4	2.66e-03	204	53	4	PS00018
Domain	ZINC_PROTEASE	MEP1A SPRTN MMP15	2.71e-03	98	53	3	PS00142
Domain	ZnMc	MEP1A MMP15	3.05e-03	29	53	2	SM00235
Domain	Peptidase_Metallo	MEP1A MMP15	3.05e-03	29	53	2	IPR006026
Domain	EF_HAND_2	USP32 NECAB3 NINL PLCD4	4.15e-03	231	53	4	PS50222
Domain	EF_hand_dom	USP32 NECAB3 NINL PLCD4	4.22e-03	232	53	4	IPR002048
Pathway	WP_WNT_SIGNALING_PATHWAY	FZD7 WNT2 LRP1 DLG4 FZD2	9.43e-06	110	37	5	MM15977
Pathway	PID_WNT_SIGNALING_PATHWAY	FZD7 WNT2 FZD2	5.21e-05	28	37	3	M77
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD7 WNT2 FZD2	1.12e-04	36	37	3	M39699
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	FZD7 WNT2 FZD2	2.05e-04	44	37	3	MM15878
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	FZD7 WNT2 FZD2	2.19e-04	45	37	3	M47412
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	FZD7 WNT2 FZD2	2.34e-04	46	37	3	M47409
Pathway	KEGG_BASAL_CELL_CARCINOMA	FZD7 WNT2 FZD2	3.98e-04	55	37	3	M17807
Pathway	WP_WNT_SIGNALING	FZD7 WNT2 FZD2	5.39e-04	61	37	3	MM15893
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	FZD7 FZD2	5.98e-04	14	37	2	M47834
Pathway	KEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY	FZD7 FZD2	7.86e-04	16	37	2	M47823
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	FZD7 WNT2 MMP15 FZD2	8.07e-04	161	37	4	M39770
Pathway	WP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS	FZD7 LRP1	8.89e-04	17	37	2	M39525
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO	FZD7 FZD2	1.11e-03	19	37	2	M47833
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	FZD7 WNT2 FZD2	1.42e-03	85	37	3	M48315
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	FZD7 WNT2 FZD2	1.62e-03	89	37	3	M39563
Pathway	WNT_SIGNALING	FZD7 WNT2 FZD2	1.62e-03	89	37	3	M5493
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	FZD7 WNT2 FZD2	1.89e-03	94	37	3	M797
Pathway	WP_GPCRS_OTHER	FZD7 ADRB1 FZD2	2.01e-03	96	37	3	MM15939
Pathway	WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER	FZD7 WNT2 FZD2	2.13e-03	98	37	3	M39731
Pathway	KEGG_MELANOGENESIS	FZD7 WNT2 FZD2	2.32e-03	101	37	3	M7761
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	FZD7 WNT2 FZD2	2.32e-03	101	37	3	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	FZD7 WNT2 FZD2	2.32e-03	101	37	3	M39387
Pathway	REACTOME_TRP_CHANNELS	TRPV6 TRPV5	2.43e-03	28	37	2	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPV6 TRPV5	2.43e-03	28	37	2	M27241
Pubmed	FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways.	FZD7 WNT2 FZD2	7.46e-08	6	55	3	36867021
Pubmed	Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.	FZD7 DLG4 FZD2	3.12e-07	9	55	3	12067714
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	FZD7 TRPV6 TRPV5	1.06e-06	13	55	3	22266179
Pubmed	Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.	FZD7 WNT2 FZD2	1.68e-06	15	55	3	15617677
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV6 TRPV5	2.46e-06	2	55	2	20405023
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV6 TRPV5	2.46e-06	2	55	2	20178461
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV6 TRPV5	2.46e-06	2	55	2	22354706
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV6 TRPV5	2.46e-06	2	55	2	16564089
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV6 TRPV5	2.46e-06	2	55	2	11846401
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV6 TRPV5	2.46e-06	2	55	2	25164318
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV6 TRPV5	2.46e-06	2	55	2	19295174
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV6 TRPV5	2.46e-06	2	55	2	23968883
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV6 TRPV5	2.46e-06	2	55	2	12390878
Pubmed	beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.	ADRB1 DLG4	2.46e-06	2	55	2	10995758
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV6 TRPV5	2.46e-06	2	55	2	12574114
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV6 TRPV5	2.46e-06	2	55	2	24761864
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV6 TRPV5	2.46e-06	2	55	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV6 TRPV5	2.46e-06	2	55	2	19140341
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV6 TRPV5	2.46e-06	2	55	2	30916584
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV6 TRPV5	2.46e-06	2	55	2	15123711
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV6 TRPV5	2.46e-06	2	55	2	12077127
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV6 TRPV5	2.46e-06	2	55	2	16565876
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV6 TRPV5	2.46e-06	2	55	2	11719848
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV6 TRPV5	2.46e-06	2	55	2	17233615
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV6 TRPV5	2.46e-06	2	55	2	24592736
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV6 TRPV5	2.46e-06	2	55	2	16705151
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD7 WNT2 FZD2	5.64e-06	22	55	3	17064353
Pubmed	β1-Adrenergic receptor signaling activates the epithelial calcium channel, transient receptor potential vanilloid type 5 (TRPV5), via the protein kinase A pathway.	ADRB1 TRPV5	7.36e-06	3	55	2	24828496
Pubmed	Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.	TRPV6 TRPV5	7.36e-06	3	55	2	17200157
Pubmed	Association of mRNA Expression Levels of LRP1 and Actin-Binding Proteins with the Development of Laryngeal and Laryngopharyngeal Squamous Cell Carcinoma.	EZR LRP1	7.36e-06	3	55	2	33108559
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2B NUTM2A	7.36e-06	3	55	2	22456610
Pubmed	Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.	FZD7 FZD2	7.36e-06	3	55	2	9813155
Pubmed	A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.	TRPV6 TRPV5	7.36e-06	3	55	2	27291418
Pubmed	Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.	FZD7 FZD2	7.36e-06	3	55	2	27680706
Pubmed	Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.	TRPV6 TRPV5	7.36e-06	3	55	2	19922080
Pubmed	Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway.	WNT2 FZD2	7.36e-06	3	55	2	29259372
Pubmed	Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.	TRPV6 TRPV5	7.36e-06	3	55	2	16763551
Pubmed	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.	TRPV6 TRPV5	7.36e-06	3	55	2	16380433
Pubmed	Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.	TRPV6 TRPV5	7.36e-06	3	55	2	16354700
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	7.36e-06	3	55	2	26542179
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD7 WNT2 FZD2	1.33e-05	29	55	3	18364260
Pubmed	Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.	TRPV6 TRPV5	1.47e-05	4	55	2	12660155
Pubmed	Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.	FZD7 FZD2	1.47e-05	4	55	2	18215320
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	NUTM2E EZR NUTM2B NINL DLG4 FUNDC1 TGM6 TRAM2 PLXNB2 TRRAP	2.20e-05	1242	55	10	30973865
Pubmed	Role and regulation of TRP channels in neutrophil granulocytes.	TRPV6 TRPV5	2.45e-05	5	55	2	12765698
Pubmed	Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).	TRPV6 TRPV5	2.45e-05	5	55	2	22407925
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD7 WNT2 FZD2	2.57e-05	36	55	3	24151333
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	FZD7 WNT2 FZD2	2.80e-05	37	55	3	15342465
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	FZD7 WNT2 FZD2	2.80e-05	37	55	3	18800919
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	FZD7 WNT2 FZD2	3.04e-05	38	55	3	18635608
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	FZD7 WNT2 FZD2	3.04e-05	38	55	3	21041481
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	FZD7 PLXNB2 FZD2 EPHA1	3.63e-05	117	55	4	17145500
Pubmed	The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.	LRP1 MMP15	3.67e-05	6	55	2	14645246
Pubmed	Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.	FZD7 FZD2	3.67e-05	6	55	2	20802536
Pubmed	Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.	LRP1 DLG4	5.13e-05	7	55	2	19036954
Pubmed	beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.	ADRB1 DLG4	5.13e-05	7	55	2	11526121
Pubmed	Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.	LRP1 DLG4	5.13e-05	7	55	2	23760271
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	FZD7 WNT2 FZD2	5.78e-05	47	55	3	28813421
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	FZD7 WNT2 FZD2	5.78e-05	47	55	3	33141892
Pubmed	Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.	FZD7 WNT2 FZD2	5.78e-05	47	55	3	18351675
Pubmed	Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.	FZD7 WNT2 FZD2	6.55e-05	49	55	3	19562671
Pubmed	HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.	LRP1 DLG4	6.83e-05	8	55	2	17360663
Pubmed	Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.	ADRB1 DLG4	6.83e-05	8	55	2	16316992
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	FZD7 FZD2	6.83e-05	8	55	2	19388021
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	TRPV6 TRPV5	6.83e-05	8	55	2	33859252
Pubmed	Wnt signaling in heart valve development and osteogenic gene induction.	WNT2 FZD2	8.78e-05	9	55	2	19961844
Pubmed	Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.	WNT2 FZD2	8.78e-05	9	55	2	19038973
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD7 FZD2	8.78e-05	9	55	2	9707618
Pubmed	Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.	FZD7 FZD2	8.78e-05	9	55	2	23095888
Pubmed	The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum.	LRP1 DLG4	8.78e-05	9	55	2	33762741
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD7 FZD2	1.10e-04	10	55	2	17532316
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD7 FZD2	1.10e-04	10	55	2	15245425
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD7 FZD2	1.34e-04	11	55	2	30978219
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD7 FZD2	1.34e-04	11	55	2	24860427
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD7 FZD2	1.34e-04	11	55	2	17582687
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD7 FZD2	1.34e-04	11	55	2	17576136
Pubmed	Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.	FZD7 WNT2 FZD2	1.46e-04	64	55	3	24431302
Pubmed	The ins and outs of HIV-1 Tat.	LRP1 PLCD4	1.60e-04	12	55	2	21951552
Pubmed	Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.	ASGR1 EXOC3L4 DLG4	1.74e-04	68	55	3	22001757
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	FZD7 FZD2	1.89e-04	13	55	2	21246654
Pubmed	Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1.	STRN DLG4	1.89e-04	13	55	2	30185604
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP1 DLG4	2.21e-04	14	55	2	17389516
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 DLG4	2.21e-04	14	55	2	15082773
Pubmed	Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.	LRP1 DLG4	2.90e-04	16	55	2	26263173
Pubmed	Mesenchymal Wnt signaling promotes formation of sternum and thoracic body wall.	FZD7 WNT2	3.29e-04	17	55	2	25727890
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD7 FZD2	3.29e-04	17	55	2	28733458
Pubmed	Discovery and refinement of loci associated with lipid levels.	PGS1 LRP1 DLG4 DNAH11	3.52e-04	211	55	4	24097068
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 DLG4	3.70e-04	18	55	2	10827173
Pubmed	Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.	LRP1 DLG4	3.70e-04	18	55	2	19455133
Pubmed	Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.	FZD7 WNT2 FZD2	3.99e-04	90	55	3	19515997
Pubmed	Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.	LRP1 DLG4	4.13e-04	19	55	2	32579270
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD7 FZD2	4.13e-04	19	55	2	21623369
Pubmed	A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration.	WNT2 FZD2	4.58e-04	20	55	2	18536717
Pubmed	Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.	TPO EZR	5.06e-04	21	55	2	23707896
Pubmed	Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.	FZD7 WNT2	5.56e-04	22	55	2	12815618
Pubmed	Motor neurons with axial muscle projections specified by Wnt4/5 signaling.	FZD7 FZD2	5.56e-04	22	55	2	19285468
Pubmed	Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition.	FZD7 WNT2	5.56e-04	22	55	2	27913639
Pubmed	Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.	FZD7 WNT2	6.63e-04	24	55	2	26744331
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPV6 TRPV5	6.63e-04	24	55	2	33884443
Pubmed	A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.	FZD7 FZD2	6.63e-04	24	55	2	9096311
Interaction	WNT3A interactions	WNT2 LRP1 DLG4 FZD2	8.92e-06	49	54	4	int:WNT3A
Cytoband	10q22.3	NUTM2E NUTM2B	1.23e-03	43	55	2	10q22.3
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD7 FZD2	1.98e-04	11	35	2	286
GeneFamily	EF-hand domain containing	USP32 NECAB3 NINL PLCD4	8.17e-04	219	35	4	863
GeneFamily	Transient receptor potential cation channels	TRPV6 TRPV5	1.33e-03	28	35	2	249
ToppCell	control-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MOSPD2 ASGR1 LRP1 PLXNB2 FZD2	4.79e-06	200	55	5	107a0665fb20247511a430178effd7630a619488
Disease	Endometrial Stromal Sarcoma	NUTM2B NUTM2A	3.28e-05	5	54	2	C0206630
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	4.91e-05	6	54	2	C0334488
Disease	apolipoprotein B measurement	PGS1 ADRB1 ASGR1 PRR30 DLG4 TMEM101 DNAH11	1.98e-04	663	54	7	EFO_0004615
Disease	Mental deterioration	STRN DNAH11	1.29e-03	29	54	2	HP_0001268
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	PGS1 ADRB1 ASGR1 DLG4	1.64e-03	276	54	4	EFO_0004612, EFO_0020943
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	PGS1 ADRB1 ASGR1 DLG4	2.65e-03	315	54	4	EFO_0004612, EFO_0008591
Disease	platelet measurement	FAM187B STRN EXOC3L4 FZD2	2.65e-03	315	54	4	EFO_0005036
Disease	reticulocyte count	PITPNM2 FAM187B PGS1 STRN ADRB1 USP32 PLXNB2	2.84e-03	1045	54	7	EFO_0007986
Disease	pulmonary function measurement, smoking behaviour measurement, FEV/FEC ratio	LRP1 MMP15	3.37e-03	47	54	2	EFO_0003892, EFO_0004713, EFO_0005671
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	ADRB1 TRAM2	3.66e-03	49	54	2	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	developmental disorder of mental health (implicated_via_orthology)	DLG4 PLXNB2	3.66e-03	49	54	2	DOID:0060037 (implicated_via_orthology)
Disease	pulmonary function measurement, FEV/FEC ratio	LRP1 MMP15	4.27e-03	53	54	2	EFO_0003892, EFO_0004713
Disease	Premature atrial contractions	LDHD ADRB1	4.59e-03	55	54	2	HP_0006699
Disease	hair colour measurement	FZD7 EZR LRP1 NINL PLXNB2	5.28e-03	615	54	5	EFO_0007822
Disease	response to opioid	ADRB1 USP32	5.61e-03	61	54	2	EFO_0008541
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	PGS1 ADRB1 ASGR1	6.40e-03	206	54	3	EFO_0004612, EFO_0020947
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ASGR1 DLG4	6.74e-03	67	54	2	EFO_0008595, EFO_0020946
Disease	free cholesterol measurement, very low density lipoprotein cholesterol measurement	ADRB1 ASGR1 DNAH11	7.20e-03	215	54	3	EFO_0008317, EFO_0008591

Protein segments in the cluster

Peptide	Gene	Start	Entry
MHWWRAESDEARRCY	ADRB1	196	P08588
VNWVEHERSCYWFSR	ASGR1	156	P07306
WRQHWEEAVRRSAQE	EXOC3L4	241	Q17RC7
DTDHWLRSNWIYRGE	EPHA1	76	P21709
WNPYVASWIDRRRHQ	DNAH11	2326	Q96DT5
SREENWQEWRQRDEQ	GKAP1	106	Q5VSY0
QHLSRWAEDGRWVEY	FBXW9	151	Q5XUX1
HIFWTDWVRRAVQRA	LRP1	2431	Q07954
WFWRVRHNRVLDNYP	MMP15	391	P51511
VSNRWTCQWDLRYHE	PLXNB2	631	O15031
RVQLQEYWRRGWTFH	PGS1	451	Q32NB8
WWENSHVFTDAQRRE	TPO	671	P07202
FYEQAFREHWERSWV	FZD2	481	Q14332
EYLIHFNGWNRSWDR	MSL3	51	Q8N5Y2
VRAHRQAWCWQDEWY	PITPNM2	221	Q9BZ72
RWRASFTYGEWEREN	GARIN1B	301	Q96KD3
YEQAFREHWERTWLL	FZD7	491	O75084
REDVLHWLRWAEQEY	ETV7	56	Q9Y603
WSRDHAYSRRGWENA	DSCR9	86	P59020
LDLTEYARRHQWWNR	FUNDC1	21	Q8IVP5
EERSRLWTARHNAWY	LDHD	361	Q86WU2
QWWRDVTRESTYQGH	MT-CO3	56	P00414
HVIDASDEEWWQARR	DLG4	461	P78352
RWRAVNLHWDVLNYD	MARCHF11	311	A6NNE9
DQWEDRIQVWHAEHR	EZR	166	P15311
EAQWRENDAQWREAR	FAM187B	306	Q17R55
REYSRQVHEWLWQSY	FAM8A1	111	Q9UBU6
WRAMREWQHTSNFDR	NUTM2A	381	Q8IVF1
WRAMREWQHTSNFDR	NUTM2B	381	A6NNL0
WRAMREWQHTSNFDR	NUTM2E	381	B1AL46
QQDDNWVESYLSWRH	MOSPD2	41	Q8NHP6
WQQAWERRESLYAHH	SFI1	326	A8K8P3
WNQERRRAWQASRES	RGS19	51	P49795
LQHEWARFEVERAQW	STRN	56	O43815
HQERLDQWLSDWFQR	PLCD4	131	Q9BRC7
YCPDRSWEREWHNQS	HEPH	746	Q9BQS7
EQSRTDRDDYVNIWW	MEP1A	166	Q16819
IWHCVRDTYHRERVW	SLC25A47	36	Q6Q0C1
EHVRFFYQNIWRSWD	SHCBP1	196	Q8NEM2
FWEQAHRQRAALEWD	NINL	461	Q9Y2I6
NRDWRYHKEERVWIT	CNOT2	466	Q9NZN8
EWTAECQHQFRQHRW	WNT2	71	P09544
AEQEAQAPHWWRTYR	MRPL38	61	Q96DV4
IHSQLRHWREYWNEQ	TRAM2	311	Q15035
RWFQRRESWAQSRDE	TRPV6	61	Q9H1D0
DRDRWSWDRHHVDFD	nan	526	Q6ZUG5
HDEVDEYRRHWWRCN	SPRTN	156	Q9H040
DRRSWVEQDHWSFED	ZSCAN29	226	Q8IWY8
SNRQTWRWHQYRDTG	PRR30	171	Q53SZ7
WDRSQEFFFWHSRVR	WDR87	816	Q6ZQQ6
VWFRENWHEEVLRQL	TRRAP	3326	Q9Y4A5
TWLWHEDESRERVYS	TGM6	401	O95932
WEVAAEAWDNHLRRN	USP32	861	Q8NFA0
THWRVAQERDELWRA	TRPV5	581	Q9NQA5
NVAYWHNTRRVEFWN	TMEM101	221	Q96IK0
RSREAVEQWRQWHYD	UCMA	111	Q8WVF2
YEFWQDEASWRRHQQ	NECAB3	346	Q96P71