Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	biotin binding	ACACA PC	1.91e-04	6	72	2	GO:0009374
GeneOntologyMolecularFunction	growth factor binding	PDGFB GLG1 LRP2 KDR FGFR2	2.51e-04	156	72	5	GO:0019838
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA PC	2.66e-04	7	72	2	GO:0016885
GeneOntologyBiologicalProcess	phospholipid biosynthetic process	PIK3R4 LPIN1 PDGFB PLA2G4A ATM PC MVK EFR3A	5.26e-06	268	74	8	GO:0008654
Domain	HIF-1_TAD_C	HIF1A EPAS1	1.42e-05	2	71	2	IPR014887
Domain	HIF-1a_CTAD	HIF1A EPAS1	1.42e-05	2	71	2	PF08778
Domain	HIF_alpha_subunit	HIF1A EPAS1	4.26e-05	3	71	2	IPR021537
Domain	HIF-1	HIF1A EPAS1	4.26e-05	3	71	2	PF11413
Domain	GHMP_KINASES_ATP	GALK2 MVK	8.51e-05	4	71	2	PS00627
Domain	Mevalonate/galactokinase	GALK2 MVK	8.51e-05	4	71	2	IPR006206
Domain	GHMP_knse_ATP-bd_CS	GALK2 MVK	8.51e-05	4	71	2	IPR006203
Domain	PAS-assoc_C	HIF1A KCNH2 EPAS1	1.01e-04	24	71	3	IPR000700
Domain	PAS	HIF1A KCNH2 EPAS1	1.14e-04	25	71	3	PF00989
Domain	PAS_fold	HIF1A KCNH2 EPAS1	1.14e-04	25	71	3	IPR013767
Domain	PAC	HIF1A KCNH2 EPAS1	1.29e-04	26	71	3	IPR001610
Domain	PAC	HIF1A KCNH2 EPAS1	1.29e-04	26	71	3	SM00086
Domain	PAC	HIF1A KCNH2 EPAS1	1.29e-04	26	71	3	PS50113
Domain	GHMP_kinase_C_dom	GALK2 MVK	1.41e-04	5	71	2	IPR013750
Domain	Biotin_BS	ACACA PC	1.41e-04	5	71	2	IPR001882
Domain	GHMP_kinases_C	GALK2 MVK	1.41e-04	5	71	2	PF08544
Domain	Biotin_carb_C	ACACA PC	1.41e-04	5	71	2	SM00878
Domain	Biotin_carb_C	ACACA PC	1.41e-04	5	71	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA PC	1.41e-04	5	71	2	IPR011764
Domain	GHMP_kinase_N_dom	GALK2 MVK	1.41e-04	5	71	2	IPR006204
Domain	Biotin_COase_C	ACACA PC	1.41e-04	5	71	2	IPR005482
Domain	GHMP_kinases_N	GALK2 MVK	1.41e-04	5	71	2	PF00288
Domain	-	GALK2 MVK	1.41e-04	5	71	2	3.30.70.890
Domain	BIOTIN	ACACA PC	1.41e-04	5	71	2	PS00188
Domain	BC	ACACA PC	1.41e-04	5	71	2	PS50979
Domain	Rudment_hybrid_motif	ACACA PC	2.12e-04	6	71	2	IPR011054
Domain	PAS	HIF1A KCNH2 EPAS1	2.41e-04	32	71	3	SM00091
Domain	PAS	HIF1A KCNH2 EPAS1	2.89e-04	34	71	3	IPR000014
Domain	PAS	HIF1A KCNH2 EPAS1	2.89e-04	34	71	3	PS50112
Domain	CPSase_L_D2	ACACA PC	2.96e-04	7	71	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA PC	2.96e-04	7	71	2	IPR005479
Domain	BC-like_N	ACACA PC	2.96e-04	7	71	2	IPR005481
Domain	Biotin_carb_N	ACACA PC	2.96e-04	7	71	2	PF00289
Domain	Biotin_lipoyl	ACACA PC	5.04e-04	9	71	2	PF00364
Domain	Biotin_lipoyl	ACACA PC	6.29e-04	10	71	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA PC	6.29e-04	10	71	2	PS50968
Domain	Single_hybrid_motif	ACACA PC	9.18e-04	12	71	2	IPR011053
Domain	-	ACACA PC	1.08e-03	13	71	2	3.40.50.20
Domain	ATP-grasp	ACACA PC	1.26e-03	14	71	2	IPR011761
Domain	PreATP-grasp_dom	ACACA PC	1.26e-03	14	71	2	IPR016185
Domain	ATP_GRASP	ACACA PC	1.26e-03	14	71	2	PS50975
Domain	-	ACACA PC	1.45e-03	15	71	2	3.30.1490.20
Domain	ARM-type_fold	PIK3R4 USP9X INTS4 ATM HUWE1 EFR3A	1.82e-03	339	71	6	IPR016024
Domain	ATP_grasp_subdomain_1	ACACA PC	2.10e-03	18	71	2	IPR013815
Domain	-	ACACA PC	2.10e-03	18	71	2	3.30.470.20
Domain	-	GALK2 MVK	2.86e-03	21	71	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	GALK2 MVK	3.13e-03	22	71	2	IPR014721
Domain	PAS_fold_3	HIF1A EPAS1	3.42e-03	23	71	2	IPR013655
Domain	PAS_3	HIF1A EPAS1	3.42e-03	23	71	2	PF08447
Domain	ARM-like	PIK3R4 USP9X INTS4 HUWE1 EFR3A	3.64e-03	270	71	5	IPR011989
Pathway	WP_ANGIOGENESIS	HIF1A PDGFB KDR FGFR2	1.93e-06	24	54	4	M39556
Pathway	WP_OSTEOARTHRITIC_CHONDROCYTE_HYPERTROPHY	HIF1A KDR FGFR2 EPAS1	3.89e-05	50	54	4	M48087
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACA SCD PC	7.77e-05	22	54	3	M39440
Pathway	REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM	ACACA PC MMUT	7.77e-05	22	54	3	M27243
Pathway	WP_FATTY_ACID_BIOSYNTHESIS	ACACA SCD PC	8.91e-05	23	54	3	MM15885
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	ACACA LRP2 PC NAXE MMUT	9.32e-05	120	54	5	MM14771
Pathway	REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS	ACACA LRP2 PC NAXE MMUT	1.22e-04	127	54	5	M27093
Pathway	REACTOME_PTK6_EXPRESSION	HIF1A EPAS1	1.43e-04	5	54	2	M27735
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	PIK3R4 HIF1A ACACA PDGFB KDR FGFR2 EPAS1	1.44e-04	302	54	7	M39719
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR	HIF1A EPAS1	2.14e-04	6	54	2	MM14521
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTOR_SIGNALING_PATHWAY	PIK3R4 HIF1A ACACA PDGFB KDR FGFR2 EPAS1	2.31e-04	326	54	7	MM15917
Pathway	WP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA	HIF1A PDGFB EPAS1	2.92e-04	34	54	3	M39771
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	HIF1A ACACA PDGFB KDR	3.24e-04	86	54	4	M39375
Pathway	REACTOME_DISEASES_OF_METABOLISM	ACACA CHST14 VCAN PC MMUT OPLAH	3.71e-04	250	54	6	M27554
Pathway	WP_NEOVASCULARIZATION_PROCESSES	HIF1A PDGFB KDR	3.76e-04	37	54	3	M39506
Pathway	REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE	CHST14 VCAN	3.97e-04	8	54	2	M27260
Pathway	REACTOME_DEFECTS_IN_BIOTIN_BTN_METABOLISM	ACACA PC	3.97e-04	8	54	2	M27248
Pathway	KEGG_MEDICUS_REFERENCE_HIF_1_SIGNALING_PATHWAY	HIF1A PDGFB	5.10e-04	9	54	2	M47421
Pathway	WP_BIOTIN_METABOLISM_INCLUDING_IMDS	ACACA PC	5.10e-04	9	54	2	M40064
Pathway	REACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP	ACACA SCD MVK	5.49e-04	42	54	3	M27172
Pathway	WP_GENES_CONTROLLING_NEPHROGENESIS	PDGFB KDR FGFR2	6.30e-04	44	54	3	M39891
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	CHST14 VCAN	6.35e-04	10	54	2	MM14801
Pathway	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	ACACA LRP2 PC NAXE MMUT	7.63e-04	189	54	5	MM14772
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	CHST14 VCAN	7.75e-04	11	54	2	M27105
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR	HIF1A EPAS1	7.75e-04	11	54	2	M26924
Pathway	REACTOME_PEXOPHAGY	ATM EPAS1	7.75e-04	11	54	2	M29846
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA PC	7.75e-04	11	54	2	M27086
Pathway	REACTOME_BIOTIN_TRANSPORT_AND_METABOLISM	ACACA PC	7.75e-04	11	54	2	MM14764
Pathway	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	ACACA LRP2 PC NAXE MMUT	9.40e-04	198	54	5	M18311
Pathway	REACTOME_SIGNALING_BY_PTK6	HIF1A KHDRBS2 EPAS1	1.15e-03	54	54	3	M29742
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	ACACA SCD MVK	1.21e-03	55	54	3	M27001
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	PDGFB KDR FGFR2	1.21e-03	55	54	3	M47952
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_VHL_TO_HIF_1_SIGNALING_PATHWAY	HIF1A PDGFB	1.27e-03	14	54	2	M47422
Pathway	REACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM	LRP2 MMUT	1.46e-03	15	54	2	MM14762
Pathway	WP_ADIPOGENESIS	LPIN1 HIF1A SCD EPAS1	1.57e-03	131	54	4	M39505
Pathway	WP_ADIPOGENESIS_GENES	LPIN1 HIF1A SCD EPAS1	1.85e-03	137	54	4	MM15970
Pubmed	Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins.	HIF1A KDR EPAS1	3.69e-08	4	74	3	19021062
Pubmed	Hypoxic-ischemic gene expression profile in the isolated variant of biliary atresia.	HIF1A KDR EPAS1	3.69e-08	4	74	3	26510548
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	UBR1 TCAF1 ACACA GLG1 USP9X KDM3B NAP1L4 HUWE1 PC PLXNB2 CPSF3 MMUT VCL MVK RBM17	1.58e-07	1367	74	15	32687490
Pubmed	Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.	HIF1A SCD FGFR2 EPAS1	1.62e-07	23	74	4	23451260
Pubmed	A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.	HIF1A KDR EPAS1	3.22e-07	7	74	3	9113979
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	LPIN1 USP9X ATM HUWE1 PLXNB2 CPSF3 GTF3C3 RBM17	3.54e-07	313	74	8	38270169
Pubmed	Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.	HIF1A PDGFB EPAS1	5.14e-07	8	74	3	18070924
Pubmed	mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle.	LPIN1 ACACA SCD	5.14e-07	8	74	3	20603810
Pubmed	Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.	HIF1A KDR EPAS1	7.70e-07	9	74	3	12053176
Pubmed	Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.	PDGFB KDR FGFR2	1.51e-06	11	74	3	17981115
Pubmed	Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.	HIF1A PDGFB KDR FGFR2	4.37e-06	51	74	4	26764350
Pubmed	Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.	HIF1A EPAS1	4.47e-06	2	74	2	31515405
Pubmed	Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.	HIF1A EPAS1	4.47e-06	2	74	2	21841824
Pubmed	A microfluidic oxygen gradient demonstrates differential activation of the hypoxia-regulated transcription factors HIF-1α and HIF-2α.	HIF1A EPAS1	4.47e-06	2	74	2	28840922
Pubmed	ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.	HIF1A EPAS1	4.47e-06	2	74	2	23437279
Pubmed	Phosphorylated pVEGFR2/KDR receptor expression in uveal melanomas: relation with HIF2α and survival.	KDR EPAS1	4.47e-06	2	74	2	21984395
Pubmed	Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke.	HIF1A EPAS1	4.47e-06	2	74	2	26746864
Pubmed	HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer.	HIF1A EPAS1	4.47e-06	2	74	2	20559021
Pubmed	Loss of either hypoxia inducible factor 1 or 2 promotes lung cancer cell colonization.	HIF1A EPAS1	4.47e-06	2	74	2	21610325
Pubmed	Effect of radiation and ibuprofen on normoxic renal carcinoma cells overexpressing hypoxia-inducible factors by loss of von Hippel-Lindau tumor suppressor gene function.	HIF1A EPAS1	4.47e-06	2	74	2	15217953
Pubmed	Constitutive expression of HIF-α plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	25046225
Pubmed	Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.	HIF1A EPAS1	4.47e-06	2	74	2	26531845
Pubmed	Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	20032376
Pubmed	The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability.	HIF1A EPAS1	4.47e-06	2	74	2	36482296
Pubmed	Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner.	HIF1A EPAS1	4.47e-06	2	74	2	24726658
Pubmed	Subcellular localization and role of lipin-1 in human macrophages.	LPIN1 PLA2G4A	4.47e-06	2	74	2	21478406
Pubmed	Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.	HIF1A EPAS1	4.47e-06	2	74	2	17437013
Pubmed	DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance.	HIF1A EPAS1	4.47e-06	2	74	2	32718321
Pubmed	Apolipoprotein A-I Binding Protein Inhibits the Formation of Infantile Hemangioma through Cholesterol-Regulated Hypoxia-Inducible Factor 1α Activation.	HIF1A NAXE	4.47e-06	2	74	2	37832842
Pubmed	Hypoxia inducible factor: a potential prognostic biomarker in oral squamous cell carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	26880584
Pubmed	Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	15964822
Pubmed	Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.	HIF1A EPAS1	4.47e-06	2	74	2	17562539
Pubmed	[Expression of HIF-1alpha mRNA and HIF-2alpha mRNA in placentas of pregnant women with intrahepatic cholestasis of pregnancy].	HIF1A EPAS1	4.47e-06	2	74	2	17718430
Pubmed	Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2.	HIF1A EPAS1	4.47e-06	2	74	2	24363272
Pubmed	The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.	HIF1A EPAS1	4.47e-06	2	74	2	17804822
Pubmed	Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats.	HIF1A EPAS1	4.47e-06	2	74	2	20005221
Pubmed	Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.	HIF1A EPAS1	4.47e-06	2	74	2	30429208
Pubmed	HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.	HIF1A EPAS1	4.47e-06	2	74	2	29176561
Pubmed	Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.	HIF1A EPAS1	4.47e-06	2	74	2	12123724
Pubmed	Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.	HIF1A EPAS1	4.47e-06	2	74	2	32515984
Pubmed	Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha.	HIF1A EPAS1	4.47e-06	2	74	2	20140661
Pubmed	Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.	HIF1A EPAS1	4.47e-06	2	74	2	12823854
Pubmed	Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.	HIF1A KDR	4.47e-06	2	74	2	21307392
Pubmed	The acquired radioresistance in HeLa cells under conditions mimicking hypoxia was attenuated by a decreased expression of HIF subunit genes induced by RNA interference.	HIF1A EPAS1	4.47e-06	2	74	2	25805230
Pubmed	Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids.	HIF1A EPAS1	4.47e-06	2	74	2	20513003
Pubmed	Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.	HIF1A EPAS1	4.47e-06	2	74	2	23303559
Pubmed	Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis.	HIF1A EPAS1	4.47e-06	2	74	2	19439736
Pubmed	HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide.	HIF1A EPAS1	4.47e-06	2	74	2	27249651
Pubmed	Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity.	HIF1A EPAS1	4.47e-06	2	74	2	33321829
Pubmed	Differential expression of hypoxia-inducible factors related to the invasiveness of epithelial ovarian cancer.	HIF1A EPAS1	4.47e-06	2	74	2	34824343
Pubmed	Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts.	HIF1A EPAS1	4.47e-06	2	74	2	29247885
Pubmed	Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.	HIF1A EPAS1	4.47e-06	2	74	2	34285132
Pubmed	The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration.	HIF1A EPAS1	4.47e-06	2	74	2	28232488
Pubmed	Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis.	HIF1A EPAS1	4.47e-06	2	74	2	21517900
Pubmed	The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2α via Binding to the HIF-2α bHLH and PAS Domains.	HIF1A EPAS1	4.47e-06	2	74	2	31189709
Pubmed	Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.	HIF1A EPAS1	4.47e-06	2	74	2	25953833
Pubmed	HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.	HIF1A EPAS1	4.47e-06	2	74	2	25796140
Pubmed	Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.	HIF1A EPAS1	4.47e-06	2	74	2	16263938
Pubmed	The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.	HIF1A EPAS1	4.47e-06	2	74	2	16826581
Pubmed	Cancer stem cells and hypoxia-inducible factors (Review).	HIF1A EPAS1	4.47e-06	2	74	2	29845228
Pubmed	2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2.	HIF1A EPAS1	4.47e-06	2	74	2	25218350
Pubmed	Hypoxia‑inducible factor‑1α regulates Lipin1 differently in pre‑adipocytes and mature adipocytes.	LPIN1 HIF1A	4.47e-06	2	74	2	32319636
Pubmed	Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function.	HIF1A EPAS1	4.47e-06	2	74	2	33273561
Pubmed	Hypoxia-inducible factor pathway activation in restless legs syndrome patients.	HIF1A EPAS1	4.47e-06	2	74	2	21985026
Pubmed	Clinicopathological and prognostic significance of HIF-1α and HIF-2α expression in small cell lung cancer.	HIF1A EPAS1	4.47e-06	2	74	2	23375698
Pubmed	Epidermal deletion of HIF-2α stimulates wound closure.	HIF1A EPAS1	4.47e-06	2	74	2	24037341
Pubmed	Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.	HIF1A EPAS1	4.47e-06	2	74	2	16611993
Pubmed	Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia.	HIF1A EPAS1	4.47e-06	2	74	2	30917010
Pubmed	Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.	HIF1A EPAS1	4.47e-06	2	74	2	14645546
Pubmed	Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.	HIF1A EPAS1	4.47e-06	2	74	2	37227777
Pubmed	Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.	HIF1A EPAS1	4.47e-06	2	74	2	19899108
Pubmed	Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.	HIF1A EPAS1	4.47e-06	2	74	2	16899596
Pubmed	HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.	HIF1A EPAS1	4.47e-06	2	74	2	34128478
Pubmed	Hovenia dulcis Thunb. and its active compound ampelopsin inhibit angiogenesis through suppression of VEGFR2 signaling and HIF-1α expression.	HIF1A KDR	4.47e-06	2	74	2	29039561
Pubmed	Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.	HIF1A EPAS1	4.47e-06	2	74	2	24324596
Pubmed	HIF-mediated hypoxic response is missing in severely hypoxic uterine leiomyomas.	HIF1A EPAS1	4.47e-06	2	74	2	20204822
Pubmed	The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.	HIF1A EPAS1	4.47e-06	2	74	2	16971531
Pubmed	Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic Exposure.	HIF1A EPAS1	4.47e-06	2	74	2	33966229
Pubmed	The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.	HIF1A EPAS1	4.47e-06	2	74	2	38363679
Pubmed	Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.	HIF1A EPAS1	4.47e-06	2	74	2	19454749
Pubmed	Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	27663442
Pubmed	Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	26846782
Pubmed	Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.	HIF1A EPAS1	4.47e-06	2	74	2	26422241
Pubmed	Hypoxia inducible factor 1α and hypoxia inducible factor 2α play distinct and functionally overlapping roles in oral squamous cell carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	20807755
Pubmed	Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.	HIF1A EPAS1	4.47e-06	2	74	2	12209691
Pubmed	Expression of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha with progression of keratinocytic neoplasms.	HIF1A EPAS1	4.47e-06	2	74	2	19660915
Pubmed	Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration.	HIF1A EPAS1	4.47e-06	2	74	2	25750431
Pubmed	Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.	HIF1A EPAS1	4.47e-06	2	74	2	23845627
Pubmed	The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells.	HIF1A EPAS1	4.47e-06	2	74	2	23194660
Pubmed	ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression.	CYTH2 KDR	4.47e-06	2	74	2	22002459
Pubmed	Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells.	HIF1A EPAS1	4.47e-06	2	74	2	33792560
Pubmed	HIF-1α and HIF-2α: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation.	HIF1A EPAS1	4.47e-06	2	74	2	24551189
Pubmed	Opposite prognostic roles of HIF1α and HIF2α expressions in bone metastatic clear cell renal cell cancer.	HIF1A EPAS1	4.47e-06	2	74	2	27244898
Pubmed	Hypoxia Inducible Factor (HIF) transcription factor family expansion, diversification, divergence and selection in eukaryotes.	HIF1A EPAS1	4.47e-06	2	74	2	28614393
Pubmed	HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation.	HIF1A EPAS1	4.47e-06	2	74	2	22673574
Pubmed	Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.	HIF1A EPAS1	4.47e-06	2	74	2	17097563
Pubmed	HIF-2α not HIF-1α overexpression confers poor prognosis in non-small cell lung cancer.	HIF1A EPAS1	4.47e-06	2	74	2	28653893
Pubmed	HIF1A and EPAS1 mRNA and protein expression during in vitro culture of human primary term cytotrophoblasts and effect of oxygen tension on their expression.	HIF1A EPAS1	4.47e-06	2	74	2	27692362
Pubmed	Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1α and hypoxia-inducible transcription factor-2α.	HIF1A EPAS1	4.47e-06	2	74	2	23492195
Pubmed	Hypoxia-inducible factors and the response to hypoxic stress.	HIF1A EPAS1	4.47e-06	2	74	2	20965423
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD VCAN FAM107B LRP2 FGFR2	2.83e-08	188	74	7	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	ACACA SCD PCLO ARHGAP44 LRP2 FGFR2 ADGRV1	3.15e-08	191	74	7	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	6.14e-07	183	74	6	5472cdce6d99314d229418412acf1fff6340db7d
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	ACACA SCD ARHGAP44 LRP2 FGFR2 ADGRV1	6.34e-07	184	74	6	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	6.34e-07	184	74	6	5939527d24d299e562e707469c9123890edd76be
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	6.54e-07	185	74	6	1d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	6.54e-07	185	74	6	b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	6.75e-07	186	74	6	90eaf6ffb4ce0c34fa1e79f0c8f36f217f44973b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	6.75e-07	186	74	6	bd8a9753df219084e19e7f94447856e86608325c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	7.19e-07	188	74	6	14072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IL1RAPL2 PCLO KHDRBS2 LRP2 FGFR2 ADGRV1	7.19e-07	188	74	6	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	7.42e-07	189	74	6	70eea8c94fa56bb15bee8065de47acea156794e9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2 FGFR2	7.65e-07	190	74	6	396b7225c2430db3dc55a3d0db70239b71987229
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A GLG1 USP9X FGFR2 HUWE1 VCL	9.73e-07	198	74	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A GLG1 USP9X FGFR2 HUWE1 VCL	9.73e-07	198	74	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A GLG1 USP9X FGFR2 HUWE1 VCL	1.00e-06	199	74	6	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	LPS-IL1RA-Endothelial-Epi-like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCAF1 PCLO LRP2 SLC38A7 FAM83H	1.46e-06	116	74	5	cf4e3c34570f57502ec524881d351ef8e47976d2
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-STAT1+_Naive_B\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MZB1 CLMN KHDRBS2 KDM3B MVK	5.50e-06	152	74	5	dd728aa3ffdb2c415730a62678f69cf0e8af09df
ToppCell	normal_Pleural_Fluid-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	ACACA MZB1 HARBI1 MVK EFR3A	5.68e-06	153	74	5	a156710217ef07c07a80ca6504fa0784d86380fa
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	8.95e-06	168	74	5	784ce773521e5d74570f45120e56d112bc76ff49
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	9.47e-06	170	74	5	7a4ed69c807c3761210776e8fe6680d1bd892e82
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	9.75e-06	171	74	5	a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCell	facs-Lung-nan-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	9.75e-06	171	74	5	43d8fd9b9546e84a652564fe96b514b34b06262b
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ACACA CLMN FGFR2 PC	1.09e-05	175	74	5	5c38d4b6c03473d841e6203a7efaa6dcb2d59386
ToppCell	facs-Heart-LA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.12e-05	176	74	5	077f3fe5e3482ea3f639d789bd3d584161b36c02
ToppCell	facs-Heart-LA-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.12e-05	176	74	5	fc2ba468677b19b55130c1f06737f40300cd9d2e
ToppCell	facs-Heart-LA-24m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.15e-05	177	74	5	a3f8c26d54e44688bbd678ac7ef55d8ad172617d
ToppCell	facs-GAT-Fat-3m-Lymphocytic-B_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.18e-05	178	74	5	5b6f7e8a930c239db1f31edfb61b2b9228d28663
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP44 PLA2G4A FGFR2 ADGRV1 PLXNB2	1.22e-05	179	74	5	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	facs-MAT-Fat-24m-Lymphocytic-B_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.25e-05	180	74	5	711719219bcbafdd505790eda895e7a33f21bed2
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Lymphocytic-B_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.25e-05	180	74	5	14ca8875af7cceead88fec147a4c0ef4d5a41f26
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	PDGFB KHDRBS2 KDR RPGR EPAS1	1.28e-05	181	74	5	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.28e-05	181	74	5	3510e0ecd4f098e8553946c44c2a49587d543755
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.28e-05	181	74	5	14faef1dde781d501834379f2a6413e8d6a80b72
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEK3 CLMN SCD FAM107B LRP2	1.32e-05	182	74	5	d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCell	droplet-Limb_Muscle-nan-24m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.32e-05	182	74	5	6946ab8d91fb8dce5af065f57a13659b8d97ed5c
ToppCell	droplet-Mammary_Gland-nan-21m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.32e-05	182	74	5	97f393549c7718a32af55b2377801bfebb10cc52
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Lymphocytic-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.35e-05	183	74	5	56038766980a4186ecd3b4a327a91c12979d2364
ToppCell	droplet-Mammary_Gland-nan-21m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.35e-05	183	74	5	e7038532a6e159bb3e383cdd9c44b3b7f21c0c01
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.35e-05	183	74	5	544939a0bfef082d361d88ef70d6f0923b8d9af9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.35e-05	183	74	5	93213124e55d1b673dd345188caf8b5bd31d99fe
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Lymphocytic\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.35e-05	183	74	5	eb2f37c3d6d0502fb9eb512537fc2a002a1b92ed
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.35e-05	183	74	5	20f7b6ec2462032eda957a893ca76d5a5a01333d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.39e-05	184	74	5	f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCD VCAN FAM107B LRP2 FGFR2	1.39e-05	184	74	5	a2191dd5546efd357b23e625beb3c5820476f243
ToppCell	droplet-Fat-Scat-18m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.39e-05	184	74	5	d49d97fb02b8de259bf9bb23b71856cddbe0becc
ToppCell	droplet-Mammary_Gland-nan-18m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.39e-05	184	74	5	73ddf9d647d61381bab1e9c0d983736b6d390c15
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLMN SCD LRP2 FGFR2 PC	1.43e-05	185	74	5	fd51fef8c69e34c72017d8371ab0a0d7be5701f2
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCD VCAN FAM107B LRP2 FGFR2	1.43e-05	185	74	5	b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLMN SCD LRP2 FGFR2 PC	1.43e-05	185	74	5	bea26e369ae91006052b973cd89b4c49afa9e553
ToppCell	droplet-Fat-Mat-18m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.43e-05	185	74	5	98bb853c495eb16c3663685a8e20755bd309b520
ToppCell	droplet-Mammary_Gland-nan-3m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.43e-05	185	74	5	bf4dbb5f139566750e50a81eb062ed8b9e5786c3
ToppCell	droplet-Mammary_Gland-nan-3m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.43e-05	185	74	5	3d035bb453a5942411da4eb8b3a1ca0961a089b2
ToppCell	facs-GAT-Fat-18m-Lymphocytic-B_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.43e-05	185	74	5	1eba3b058e23a7d19024b4363dfeb522a8af313d
ToppCell	droplet-Limb_Muscle-nan-3m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.43e-05	185	74	5	a01d25a5642337cfcdef5fcd189b3150a5fad911
ToppCell	droplet-Mammary_Gland-nan-18m-Lymphocytic-B_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.46e-05	186	74	5	124a618a0911aba9fc2a071dc3ca40fc003bb1ed
ToppCell	facs-SCAT-Fat-3m-Lymphocytic-B_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.46e-05	186	74	5	d5d990d8b6ccd8ca8fe7d0d7dedbe2359ae7b582
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.46e-05	186	74	5	0018a949f9f5bfc17f823601303f04dfd56c9a38
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.50e-05	187	74	5	f0de86ef25e344d9b1860ee26308877d6c25ed31
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MZB1 STK17B SCD FAM107B SP140	1.50e-05	187	74	5	57f9c9162694c184a8fd6634ee0fad511ca71c9e
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-B_cell-B_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MZB1 STK17B SCD FAM107B SP140	1.50e-05	187	74	5	6ce6d3678026101c4397320430433c9f05740883
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCD VCAN FAM107B LRP2 FGFR2	1.50e-05	187	74	5	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.50e-05	187	74	5	b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCell	facs-BAT-Fat-3m-Lymphocytic-B_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.50e-05	187	74	5	63cc89ce24d3f8fb13479a501a20bfbd798d151a
ToppCell	facs-MAT-Fat-3m-Lymphocytic-B_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.54e-05	188	74	5	a7158b5c94e6b356877f016e52f2c24a3f5d24d2
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD FAM107B SP140	1.54e-05	188	74	5	f72bc8965872da4d7d7990895beadbe36752314f
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA SCD ARHGAP44 LRP2 FGFR2	1.54e-05	188	74	5	b1049003ca79c340bb8c78da66bdc0956e1aebc2
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.54e-05	188	74	5	b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IL1RAPL2 PCLO ARHGAP44 KHDRBS2 ADGRV1	1.54e-05	188	74	5	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLMN FAM107B FGFR2 FAM47E OPLAH	1.54e-05	188	74	5	842982de2197770f999a70083ed9fca40ac22d79
ToppCell	facs-Lung-EPCAM-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACACA SCD ARHGAP44 LRP2 FGFR2	1.54e-05	188	74	5	3dd571bd8e7358b4346dea71f6bf9602dabf583c
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLMN FAM107B FGFR2 FAM47E OPLAH	1.54e-05	188	74	5	a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCell	368C-Epithelial_cells-Epithelial-E_(AT2)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SCD LRP2 ADGRV1 SEZ6L2 FAM83H	1.58e-05	189	74	5	6f2322d017b74a1757c81d6e06f50ead8c3dd0cc
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.58e-05	189	74	5	b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.58e-05	189	74	5	42ab4cc5fbf8580841f31889446fe4499df1a464
ToppCell	368C-Epithelial_cells-Epithelial-E_(AT2)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SCD LRP2 ADGRV1 SEZ6L2 FAM83H	1.58e-05	189	74	5	926b5fa3064b501a57ba78583e8af33532add455
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.62e-05	190	74	5	07f21386ea6eb23416a537d2250e3042efe93fb0
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.62e-05	190	74	5	6b101359f397020a21e2bfd15851cb48e71f4502
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 STK17B SCD ELF1 SP140	1.62e-05	190	74	5	ee7b60cdf93c695ea2d59a170ca8cf4dc93e7eb2
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.62e-05	190	74	5	ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ELL2 ARHGAP44 KHDRBS2 FGFR2 ADGRV1	1.66e-05	191	74	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CLMN SCD FAM107B LRP2 FGFR2	1.66e-05	191	74	5	2b056cbe2e82e056e1f798974999378460eb1d16
ToppCell	facs-Lung-EPCAM-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLMN SCD ARHGAP44 LRP2 FGFR2	1.66e-05	191	74	5	629007189034ee8451411428f1c6cc57daee2d91
ToppCell	IPF-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	SLC5A5 ACACA KHDRBS2 FGFR2 EPAS1	1.70e-05	192	74	5	356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP9X ADGRV1 HUWE1 GTF3C3 EFR3A	1.75e-05	193	74	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X PCLO PC SEZ6L2 PLXNB2	1.75e-05	193	74	5	471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X PCLO PC SEZ6L2 PLXNB2	1.75e-05	193	74	5	fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLMN SCD FAM107B LRP2 FGFR2	1.79e-05	194	74	5	cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PDGFB SCD KHDRBS2 KDR EPAS1	1.79e-05	194	74	5	3c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCell	Control-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	NEK3 MZB1 CLMN PLXNB2 VCL	1.79e-05	194	74	5	5f95a5a35f73222dbe2ca52cc580f4774f641403
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ACACA ARHGAP44 KHDRBS2 FGFR2 ADGRV1	1.79e-05	194	74	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X PCLO HUWE1 PC SEZ6L2	1.84e-05	195	74	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X PCLO HUWE1 PC SEZ6L2	1.84e-05	195	74	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLMN SCD FAM107B LRP2 FGFR2	1.88e-05	196	74	5	37a5f9f3988778655580bd0383811bb4930c1551
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLMN SCD FAM107B LRP2 FGFR2	1.93e-05	197	74	5	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLMN SCD FAM107B LRP2 FGFR2	1.98e-05	198	74	5	bdabdb11217ea16e5863aa6bfb0f04d48b17f81e
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A GLG1 USP9X FGFR2 VCL	1.98e-05	198	74	5	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	COVID-19-lung-Capillary_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PDGFB KHDRBS2 KDR RPGR EPAS1	1.98e-05	198	74	5	45419f2804b4be79bae6632e71c54e1af482d115
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLMN SCD FAM107B LRP2 FGFR2	2.02e-05	199	74	5	214a6a267e77e5508867b9eb48c4fbc7855ed0a0
ToppCell	Macroglial-Oligodendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ELL2 CLMN SCD FAM107B LRP2	2.07e-05	200	74	5	4dbac2f2587e87ca5a0622f50439bb5447e93c7f
Drug	Chlorpyrifos	TCAF1 GALK2 ACACA GLG1 SCD USP9X PCLO GLRA2 FAM107B KHDRBS2 KDR FGFR2 ATM HUWE1 EPAS1	3.12e-07	960	73	15	ctd:D004390
Drug	Phenytoin	LPIN1 UBR1 PDGFB KCNH2 VCAN KHDRBS2 KDR FGFR2 ATM PLXNB2	4.10e-07	385	73	10	ctd:D010672
Drug	AC1L1F75	HIF1A ACACA EPAS1 MVK	2.17e-06	29	73	4	CID000003112
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; PC3; HT_HG-U133A	NEK3 GALK2 PDGFB IL1RAPL2 GLG1 LRP2 FGFR2	3.17e-06	196	73	7	5749_DN
Drug	phenylarsonic acid	ACACA HUWE1 PC	8.84e-06	13	73	3	CID000007365
Drug	cobalt(II) acetate	HIF1A SCD	1.01e-05	2	73	2	ctd:C521309
Drug	Semaxinib	HIF1A KCNH2 KDR	2.95e-05	19	73	3	ctd:C116890
Drug	Einecs 237-282-1	PDGFB MMUT	3.04e-05	3	73	2	CID000083686
Drug	acetyl-dephospho-CoA	ACACA PC	3.04e-05	3	73	2	CID000193680
Drug	GBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A	SERPINB8 PDGFB VCAN GLRA2 KHDRBS2 MVK	3.05e-05	187	73	6	3240_UP
Drug	Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A	LPIN1 NEK3 LRP2 RPGR MMUT MVK	3.24e-05	189	73	6	1700_UP
Drug	Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; PC3; HT_HG-U133A	LPIN1 DENND2A GALK2 VCAN SLC38A7 PLA2G4A	3.75e-05	194	73	6	4262_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; MCF7; HT_HG-U133A	PDGFB IL1RAPL2 KCNH2 VCAN LRP2 ATM	4.09e-05	197	73	6	2858_UP
Drug	Ciprofibrate [52214-84-3]; Down 200; 13.8uM; PC3; HT_HG-U133A	PDGFB IL1RAPL2 KCNH2 VCAN LRP2 PC	4.33e-05	199	73	6	5740_DN
Drug	copper carbonate	VCAN PC	6.06e-05	4	73	2	CID000014452
Drug	T67416	KCNH2 KDR	6.06e-05	4	73	2	CID000956683
Drug	exochelins	HIF1A EPAS1	6.06e-05	4	73	2	ctd:C010953
Disease	polycystic kidney disease (biomarker_via_orthology)	HIF1A PLA2G4A EPAS1	1.37e-05	19	73	3	DOID:0080322 (biomarker_via_orthology)
Disease	psoriasis (is_marker_for)	HIF1A KDR EPAS1	1.79e-04	44	73	3	DOID:8893 (is_marker_for)
Disease	morbid obesity (is_marker_for)	LPIN1 HIF1A	2.68e-04	10	73	2	DOID:11981 (is_marker_for)
Disease	Malignant Neoplasms	SLC5A5 KCNH2 KDR ATM	2.92e-04	128	73	4	C0006826
Disease	brain infarction (implicated_via_orthology)	HIF1A PDGFB	3.27e-04	11	73	2	DOID:3454 (implicated_via_orthology)
Disease	bronchopulmonary dysplasia (biomarker_via_orthology)	HIF1A EPAS1	3.92e-04	12	73	2	DOID:11650 (biomarker_via_orthology)
Disease	macular retinal edema (is_marker_for)	HIF1A KDR	3.92e-04	12	73	2	DOID:4449 (is_marker_for)
Disease	lung non-small cell carcinoma (is_implicated_in)	HIF1A KDR ATM EPAS1	3.99e-04	139	73	4	DOID:3908 (is_implicated_in)
Disease	esophageal adenocarcinoma, Barrett's esophagus, sex interaction measurement	RP1L1 KHDRBS2	4.63e-04	13	73	2	EFO_0000280, EFO_0000478, EFO_0008343
Disease	multiple myeloma, monoclonal gammopathy	ELL2 PDGFB	5.39e-04	14	73	2	EFO_0000203, EFO_0001378
Disease	Craniofacial Abnormalities	CHST14 LRP2 FGFR2 FAM83H	6.16e-04	156	73	4	C0376634
Disease	Benign Neoplasm	SLC5A5 KCNH2 ATM	6.49e-04	68	73	3	C0086692
Disease	Neoplasms	SLC5A5 KCNH2 ATM	6.49e-04	68	73	3	C0027651
Disease	rheumatoid arthritis (is_marker_for)	HIF1A PDGFB EPAS1	6.77e-04	69	73	3	DOID:7148 (is_marker_for)
Disease	Inborn Errors of Metabolism	PLA2G4A MMUT	8.02e-04	17	73	2	C0025521
Disease	Benign neoplasm of stomach	FGFR2 ATM	8.02e-04	17	73	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	FGFR2 ATM	8.02e-04	17	73	2	C0496905
Disease	Carcinoma in situ of stomach	FGFR2 ATM	8.02e-04	17	73	2	C0154060
Disease	Amelogenesis imperfecta	AMBN FAM83H	8.02e-04	17	73	2	cv:C0002452
Disease	Prostatic Neoplasms	SLC5A5 HIF1A CHST14 LRP2 INTS4 CHD6 ATM	8.27e-04	616	73	7	C0033578
Disease	Malignant neoplasm of prostate	SLC5A5 HIF1A CHST14 LRP2 INTS4 CHD6 ATM	8.27e-04	616	73	7	C0376358
Disease	pulmonary hypertension (biomarker_via_orthology)	HIF1A PDGFB EPAS1	1.04e-03	80	73	3	DOID:6432 (biomarker_via_orthology)
Disease	blood aluminium measurement	GALK2 EFR3A	1.11e-03	20	73	2	EFO_0007575
Disease	Stomach Carcinoma	FGFR2 ATM	1.23e-03	21	73	2	C0699791
Disease	Malignant neoplasm of breast	SLC5A5 PIK3R4 HIF1A IL1RAPL2 PLA2G4A KDR FGFR2 ATM CPSF3	1.30e-03	1074	73	9	C0006142
Disease	amino acid measurement	NEK3 STK17B VCAN RP1L1 LRP2 PLA2G4A EPAS1	1.44e-03	678	73	7	EFO_0005134
Disease	nevus count, cutaneous melanoma	ATM ADGRV1 PLXNB2	1.51e-03	91	73	3	EFO_0000389, EFO_0004632
Disease	Intrahepatic Cholangiocarcinoma	SLC5A5 FGFR2	1.61e-03	24	73	2	C0345905
Disease	glioblastoma (is_implicated_in)	PDGFB KDR	1.61e-03	24	73	2	DOID:3068 (is_implicated_in)
Disease	Extrahepatic Cholangiocarcinoma	SLC5A5 FGFR2	1.61e-03	24	73	2	C3805278
Disease	Liver carcinoma	SLC5A5 ACACA PDGFB SCD ATM MVK	1.61e-03	507	73	6	C2239176
Disease	Cholangiocarcinoma	SLC5A5 FGFR2	1.89e-03	26	73	2	C0206698
Disease	Mammary Carcinoma, Human	SLC5A5 HIF1A PLA2G4A KDR FGFR2 ATM	1.92e-03	525	73	6	C4704874
Disease	Mammary Neoplasms, Human	SLC5A5 HIF1A PLA2G4A KDR FGFR2 ATM	1.92e-03	525	73	6	C1257931
Disease	Mammary Neoplasms	SLC5A5 HIF1A PLA2G4A KDR FGFR2 ATM	1.95e-03	527	73	6	C1458155
Disease	Pancreatic Neoplasm	HIF1A KDR ATM	1.98e-03	100	73	3	C0030297
Disease	acute kidney failure (implicated_via_orthology)	HIF1A EPAS1	2.04e-03	27	73	2	DOID:3021 (implicated_via_orthology)
Disease	Malignant neoplasm of pancreas	HIF1A KDR ATM	2.09e-03	102	73	3	C0346647
Disease	Breast Carcinoma	SLC5A5 HIF1A PLA2G4A KDR FGFR2 ATM	2.17e-03	538	73	6	C0678222
Disease	Hodgkins lymphoma, multiple myeloma, chronic lymphocytic leukemia	ELL2 SP140	2.19e-03	28	73	2	EFO_0000095, EFO_0000183, EFO_0001378

Protein segments in the cluster

Peptide	Gene	Start	Entry
RELPEPLMTFDLYDD	BARGIN	361	Q6ZT62
FNELDLETLAPYIPM	EPAS1	521	Q99814
EMPKDLIYINDEDPS	ELF1	291	P32519
ASMEPSAIELPDYLI	ELL2	516	O00472
DLMAEILPEFPDIIE	VCAN	1366	P13611
DALPYIDLIDPAEID	CPSF3	51	Q9UKF6
AAADPLMTPELADVY	AMBN	381	Q9NP70
YSLPDEIPEEMEEFT	ADGRV1	961	Q8WXG9
PLPSDMLTYTELVLD	ACACA	1626	Q13085
LDPLLSPSLMEDYEL	EFR3A	461	Q14156
EPDMDDPAYIAVLVL	INTS4	536	Q96HW7
DTPMLAGVSEYELPE	FGFR2	456	P21802
DMLSELVQEYDEPIL	NAP1L4	171	Q99733
AEPMTIDELYELVVD	NAXE	171	Q8NCW5
DERITELMGYEPEEL	HIF1A	256	Q16665
DLDLEMLAPYIPMDD	HIF1A	556	Q16665
PLDELYEVLVETLMA	FAM86C1P	61	Q9NVL1
DDLLEVLDMYPEFSD	KCNH2	836	Q12809
PPEEEYEHMESLDLE	HARBI1	321	Q96MB7
EGDPIPEELYEMLSD	PDGFB	21	P01127
LYFDEEPELEMESLT	PCLO	1691	Q9Y6V0
PEEPEAYNLTVLIEM	PLXNB2	1061	O15031
EMLLVTEDALHPEPY	GALK2	281	Q01415
RFEDLMENLPLPEYT	KDM3B	1501	Q7LBC6
DLTDMDPEVAALYFP	LPIN1	401	Q14693
VMPSGLTLDYEEDLL	LRP2	2551	P98164
ELDEDYPDMNASPLV	HUWE1	2466	Q7Z6Z7
PPEIIMEYGEEVLEE	NEK3	266	P51956
LPLDTYVESPAAVME	FUOM	66	A2VDF0
EMTEDIRLEPDLYEA	GLG1	811	Q92896
LKELPGEEYPLPMED	ATM	951	Q13315
GEEYPLPMEDVLELL	ATM	956	Q13315
IGPEEDLPRKMEYLE	GATAD1	206	Q8WUU5
EDILDPPMKENPYED	DENND2A	371	Q9ULE3
PARELDVPLPDIDYM	CHD6	1256	Q8TD26
DVPLPDIDYMEIPVD	CHD6	1261	Q8TD26
MAEPDYIEDDNPELI	FAM107B	1	Q9H098
YEPPDLTPEERMELE	CYTH2	6	Q99418
EYPDDSLDLDPSMLD	GLRA2	111	P23416
LLDDEMDVDLEPALY	CCDC38	321	Q502W7
YLPELMAEKDSLDPS	KHDRBS2	6	Q5VWX1
PAPMEAEAYEDDVLA	FAM83H	601	Q6ZRV2
PLDELYEVLAETLMA	FAM86C2P	61	A6NEL3
GDMLDTPDPYVELFI	PLA2G4A	36	P47712
SEQDLMQPEEPDYLL	RPGR	461	Q92834
PLIEPLMEPEGESYE	SNCB	106	Q16143
PLALYLNLEEAMPIE	FAM47E	126	Q6ZV65
YSKLMGDEPDLDPDI	USP9X	701	Q93008
DLPELLLEAEYMSEL	RIN1	551	Q13671
LSLLVPEIEDMYSSP	TCAF1	506	Q9Y4C2
PERDLIPSGTYMEDL	IL1RAPL2	446	Q9NP60
LAVPMPEVLYEEVLE	OPLAH	121	O14841
ELREIMGTPEYLAPE	STK17B	191	O94768
EEEMYLLDFPCINPL	SHOC1	1041	Q5VXU9
VDPDVLLSYPSEDMA	SLC38A7	306	Q9NVC3
SPLSPVIYDSDMDDV	SEZ6L2	411	Q6UXD5
LRELPEPLMTFELYD	ARHGAP44	331	Q17R89
LELPYVEEELSMVIL	SERPINB8	216	P50452
PEKALEALEPMYDPD	GTF3C3	506	Q9Y5Q9
EALEPMYDPDTLAQD	GTF3C3	511	Q9Y5Q9
DLEEPEGYMPDLDSR	CLMN	756	Q96JQ2
PEFLRYLVDEDPERM	CHST14	261	Q8NCH0
ELEYMRDPSTPLVDL	PIK3R4	211	Q99570
EEIVELPDLDYLRTM	ZNF451	871	Q9Y4E5
LDNIPEEPILMTYEL	RP1L1	961	Q8IWN7
PDQYMPLLVLDIFED	SLC5A5	321	Q92911
PAPEQYLVLEELIDM	MVK	286	Q03426
EVLIPLADEYDPMFP	RBM17	91	Q96I25
VPPDMEDDYEPELLL	VCL	941	P18206
EDDYEPELLLMPSNQ	VCL	946	P18206
LVPEIYFAEMDPDLE	UBR1	46	Q8IWV7
PPAGLYEEIMEAEAV	SCART1	956	Q4G0T1
ETMPLYLEDDIRPDI	SCD	36	O00767
PDEELDSLPQPYRMI	WDR93	46	Q6P2C0
DEGESEEMPKLLPYD	SP140	231	Q13342
EEMPKLLPYDTEVLE	SP140	236	Q13342
YLSIVMDPDELPLDE	KDR	801	P35968
EVTPEDVLSAAMYPD	PC	1001	P11498
PEAMVLAYLEEEVLE	ZBED4	1081	O75132
PLYSKRDTMDLPEEL	MMUT	71	P22033
PLTATAPQLDDEEMY	MZB1	26	Q8WU39