Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5C KDM5D

1.58e-056212GO:0034647
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5C KDM5D

2.94e-058212GO:0032453
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5C KDM5D

3.92e-0428212GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5C KDM5D

4.81e-0431212GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5C KDM5D

5.13e-0432212GO:0140457
GeneOntologyMolecularFunctiondemethylase activity

KDM5C KDM5D

9.70e-0444212GO:0032451
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5C KDM5D

2.11e-0365212GO:0016706
GeneOntologyMolecularFunctiondioxygenase activity

KDM5C KDM5D

4.71e-0398212GO:0051213
DomainLys_sp_deMease-like_dom

KDM5C KDM5D

7.21e-064212IPR013637
DomainPLU-1

KDM5C KDM5D

7.21e-064212PF08429
Domainzf-C5HC2

KDM5C KDM5D

1.20e-055212PF02928
DomainZnf_C5HC2

KDM5C KDM5D

1.20e-055212IPR004198
DomainJmjN

KDM5C KDM5D

5.39e-0510212PF02375
DomainJmjN

KDM5C KDM5D

5.39e-0510212SM00545
DomainJMJN

KDM5C KDM5D

5.39e-0510212PS51183
DomainJmjN

KDM5C KDM5D

5.39e-0510212IPR003349
DomainLdl_recept_b

LRP1 EGF

1.09e-0414212PF00058
DomainLDLRB

LRP1 EGF

1.09e-0414212PS51120
Domain-

KDM5C KDM5D

1.25e-04152121.10.150.60
DomainARID

KDM5C KDM5D

1.25e-0415212PF01388
DomainBRIGHT

KDM5C KDM5D

1.25e-0415212SM00501
DomainARID_dom

KDM5C KDM5D

1.25e-0415212IPR001606
DomainARID

KDM5C KDM5D

1.25e-0415212PS51011
DomainLY

LRP1 EGF

1.25e-0415212SM00135
DomainLDLR_classB_rpt

LRP1 EGF

1.25e-0415212IPR000033
DomainJmjC

KDM5C KDM5D

3.27e-0424212PF02373
DomainJMJC

KDM5C KDM5D

5.85e-0432212PS51184
DomainJmjC_dom

KDM5C KDM5D

5.85e-0432212IPR003347
DomainJmjC

KDM5C KDM5D

6.23e-0433212SM00558
DomainGrowth_fac_rcpt_

LRP1 INSRR EGF

6.81e-04156213IPR009030
Domain-

LRP1 EGF

8.70e-04392122.120.10.30
Domain6-blade_b-propeller_TolB-like

LRP1 EGF

1.21e-0346212IPR011042
DomainZinc_finger_PHD-type_CS

KDM5C KDM5D

2.40e-0365212IPR019786
DomainPHD

KDM5C KDM5D

3.18e-0375212PF00628
DomainZnf_PHD-finger

KDM5C KDM5D

3.52e-0379212IPR019787
DomainEGF_CA

LRP1 EGF

4.16e-0386212PF07645
DomainPHD

KDM5C KDM5D

4.45e-0389212SM00249
DomainZnf_PHD

KDM5C KDM5D

4.64e-0391212IPR001965
DomainZF_PHD_2

KDM5C KDM5D

5.05e-0395212PS50016
DomainZF_PHD_1

KDM5C KDM5D

5.15e-0396212PS01359
DomainEGF_Ca-bd_CS

LRP1 EGF

5.26e-0397212IPR018097
DomainEGF_CA

LRP1 EGF

5.47e-0399212PS01187
DomainASX_HYDROXYL

LRP1 EGF

5.58e-03100212PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 EGF

6.25e-03106212IPR000152
DomainEGF_CA

LRP1 EGF

8.19e-03122212SM00179
DomainEGF-like_Ca-bd_dom

LRP1 EGF

8.45e-03124212IPR001881
DomainEGF

LRP1 EGF

8.72e-03126212PF00008
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5C KDM5D

3.47e-07221232081420
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5C KDM5D

3.47e-0722129060413
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5C KDM5D

3.47e-07221210441747
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5C KDM5D

3.47e-07221216416087
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5C KDM5D

3.47e-0722127524912
Pubmed

Identification of a mouse male-specific transplantation antigen, H-Y.

KDM5C KDM5D

1.04e-0632127544442
Pubmed

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.

NXF1 C9orf72

1.04e-06321228677678
Pubmed

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.

KDM5C KDM5D

2.08e-06421216541399
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5C KDM5D

2.08e-06421232732223
Pubmed

A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human.

KDM5C KDM5D

2.08e-0642127951230
Pubmed

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

KDM5C KDM5D

2.08e-06421217320160
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KDM5C KDM5D

2.70e-051321224619213
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

KDM5C KDM5D

2.70e-051321214660691
Pubmed

Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

KDM5C KDM5D

3.63e-051521214762062
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

NXF1 ADCY8 CTTNBP2 SHCBP1L

4.24e-0533121419490893
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

KDM5C KDM5D

5.28e-051821212023983
Pubmed

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.

KAZN CTTNBP2

1.30e-042821233953184
Pubmed

DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

NUP43 GPS1

1.30e-042821217079684
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5C KDM5D

1.81e-043321226864203
Pubmed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

ADCY8 CTTNBP2

2.54e-043921224709693
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM5C KDM5D

4.01e-044921234368113
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

ALMS1 KDM5C NXF1

4.03e-0424221334011540
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

NUP43 KDM5C NXF1

4.44e-0425021333536335
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM5C KDM5D

5.43e-045721218022353
GeneFamilyAT-rich interaction domain containing

KDM5C KDM5D

5.81e-0515142418
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5C KDM5D

1.52e-0424142485
GeneFamilyPHD finger proteins

KDM5C KDM5D

2.14e-039014288
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALMS1 WTIP KAZN

7.56e-051772138ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

ALPK3 LRP1 CTTNBP2

7.94e-051802137be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellsystemic_lupus_erythematosus-managed-Hematopoietic-progenitor_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

WTIP MYL6B SHCBP1L

8.61e-051852132c07991e0907ded67e21ab2e66be21695842ed01
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NUP43 WTIP TFAP2C

8.75e-0518621377bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NUP43 WTIP TFAP2C

8.75e-0518621313bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

NUP43 WTIP TFAP2C

8.89e-0518721361c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

NUP43 WTIP TFAP2C

8.89e-05187213b827d9da7032bf051756ddf88352af922eb0f87b
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

ALPK3 KAZN EGF

9.03e-05188213df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

ALPK3 KDM5D EGF

9.32e-051902133729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LRP1 KAZN CTTNBP2

1.04e-0419721331a1852911bda38543916585fda34255fd62a134
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5C KDM5D

2.62e-064202DOID:0060809 (implicated_via_orthology)
Diseasesleep disorder (implicated_via_orthology)

TFAP2C INSRR

2.39e-0511202DOID:535 (implicated_via_orthology)
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5C KDM5D

5.21e-0516202DOID:0050888 (implicated_via_orthology)
Diseasediabetes mellitus (implicated_via_orthology)

LRP1 INSRR

1.40e-0426202DOID:9351 (implicated_via_orthology)
Diseaseintellectual disability (implicated_via_orthology)

KDM5C KDM5D

1.18e-0375202DOID:1059 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

ALMS1 INSRR

2.29e-03105202DOID:9352 (implicated_via_orthology)
DiseaseGlioblastoma Multiforme

INSRR EGF

2.55e-03111202C1621958
Diseasechronotype measurement

FNBP4 ADCY8 KAZN SHCBP1L

2.62e-03882204EFO_0008328
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

EGF C9orf72

3.53e-03131202C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

EGF C9orf72

3.53e-03131202C4552091
DiseaseJuvenile arthritis

EGF C9orf72

3.53e-03131202C3495559
DiseaseJuvenile psoriatic arthritis

EGF C9orf72

3.53e-03131202C3714758
DiseaseJuvenile-Onset Still Disease

EGF C9orf72

3.74e-03135202C0087031
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5C KDM5D

4.71e-03152202DOID:0060041 (implicated_via_orthology)
Diseaseautism spectrum disorder

ZNF568 ADCY8

4.96e-03156202EFO_0003756

Protein segments in the cluster

PeptideGeneStartEntry
LDCLNGDYNVEEGHG

ADCY8

556

P40145
YEEDCEDRHDGSSNG

TFAP2C

11

Q92754
LAHDCGYSISELNED

ALMS1

2521

Q8TCU4
NGEDGEHGLLTYICD

ALPK3

486

Q96L96
DSDGGFEGDHQLLCD

NUP43

56

Q8NFH3
PDFHDDYGSLQNEDC

KAZN

736

Q674X7
GDNDCGDYSDETHAN

LRP1

1036

Q07954
DDKLLFCDGCDDNYH

KDM5D

326

Q9BY66
GDRQGLLDAYHDGAC

NXF1

401

Q9UBU9
DDLGDHYLDCGDLSN

GPS1

166

Q13098
EGYQGDGIHCLDIDE

EGF

901

P01133
NEEGLDINYSCEDGH

CTTNBP2

731

Q8WZ74
AEDGDLYLNDYCHRG

INSRR

646

P14616
LEAGLCLYGNDIDEH

AMT

266

P48728
LNDDDIGDSCHEGFL

C9orf72

206

Q96LT7
GLCLLGAYADSDDDD

FNBP4

106

Q8N3X1
QHGDLDLALDNCYSG

SHCBP1L

406

Q9BZQ2
YDCDSLDKGLEHNLD

ZNF568

176

Q3ZCX4
LAGHEDSNGCINYEA

MYL6B

186

P14649
YHCEDCGLQLSGEEG

WTIP

381

A6NIX2
DDKLLLCDGCDDNYH

KDM5C

336

P41229