Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1C SLC46A2 ABCA13 GJB4 TMC6 HTR3E TMEM175 ABCC9 PANX2 SLC30A3 SLCO6A1 SLC4A1 SLC32A1 CATSPER1 CLCN3 CLCN5 CLCN6 MIP SCN8A SLC10A6 TMC8 SLC38A6 SLC25A45	6.49e-08	1180	108	23	GO:0022857
GeneOntologyMolecularFunction	transporter activity	CACNA1C SLC46A2 ABCA13 GJB4 TMC6 HTR3E TMEM175 ABCC9 APOB PANX2 SLC30A3 SLCO6A1 SLC4A1 SLC32A1 CATSPER1 CLCN3 CLCN5 CLCN6 MIP SCN8A SLC10A6 TMC8 SLC38A6 SLC25A45	7.49e-08	1289	108	24	GO:0005215
GeneOntologyMolecularFunction	channel activity	CACNA1C GJB4 TMC6 HTR3E TMEM175 ABCC9 PANX2 CATSPER1 CLCN3 CLCN5 CLCN6 MIP SCN8A TMC8	9.22e-07	525	108	14	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1C GJB4 TMC6 HTR3E TMEM175 ABCC9 PANX2 CATSPER1 CLCN3 CLCN5 CLCN6 MIP SCN8A TMC8	9.43e-07	526	108	14	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1C TMC6 HTR3E TMEM175 ABCC9 SLC30A3 SLC4A1 SLC32A1 CATSPER1 CLCN3 CLCN5 CLCN6 SCN8A SLC10A6 TMC8	2.37e-05	793	108	15	GO:0015075
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN3 CLCN5 CLCN6	2.46e-05	11	108	3	GO:0005247
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10B ALG10	2.90e-05	2	108	2	GO:0106073
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC46A2 SLC30A3 SLCO6A1 SLC4A1 SLC32A1 CLCN3 CLCN5 CLCN6 SLC10A6	3.32e-05	296	108	9	GO:0015291
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1C TMC6 HTR3E TMEM175 ABCC9 CATSPER1 CLCN3 CLCN5 CLCN6 SCN8A TMC8	3.91e-05	459	108	11	GO:0005216
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC46A2 ABCA13 ABCC9 SLC30A3 SLCO6A1 SLC4A1 SLC32A1 CLCN3 CLCN5 CLCN6 SLC10A6	5.53e-05	477	108	11	GO:0022804
GeneOntologyMolecularFunction	gated channel activity	CACNA1C TMC6 HTR3E ABCC9 CATSPER1 CLCN3 CLCN5 CLCN6 TMC8	8.42e-05	334	108	9	GO:0022836
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCN3 CLCN5 CLCN6	9.90e-05	17	108	3	GO:0008308
GeneOntologyMolecularFunction	antiporter activity	SLC30A3 SLC4A1 SLC32A1 CLCN3 CLCN5 CLCN6	1.05e-04	138	108	6	GO:0015297
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1C TMEM175 ABCC9 SLC30A3 SLC4A1 SLC32A1 CATSPER1 CLCN3 CLCN5 CLCN6 MIP SCN8A SLC10A6	2.28e-04	758	108	13	GO:0015318
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1C ABCC9 CATSPER1 CLCN3 CLCN5 CLCN6	4.68e-04	182	108	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1C ABCC9 CATSPER1 CLCN3 CLCN5 CLCN6	4.96e-04	184	108	6	GO:0022832
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1C TMC6 HTR3E TMEM175 ABCC9 PANX2 ACE SLC30A3 ALG10B SLC4A1 SLC32A1 CATSPER1 CLCN3 CLCN5 CLCN6 PIK3C2A ALG10 SCN8A SLC10A6 TMC8 CNTN1	6.66e-06	1374	107	21	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNA1C TMC6 HTR3E TMEM175 ABCC9 PANX2 SLC30A3 ALG10B SLC4A1 SLC32A1 CATSPER1 CLCN3 CLCN5 CLCN6 PIK3C2A ALG10 SCN8A TMC8	1.62e-05	1115	107	18	GO:0034220
GeneOntologyCellularComponent	endosome	SLC46A2 ZFYVE27 TMEM175 APOB ACE SLC30A3 WDFY4 CRHBP IFNAR1 TMEM106B CLCN3 CLCN5 CLCN6 SBF2 RASGEF1B CD79A RAB40B CX3CR1 DOP1A DOP1B	2.28e-06	1167	109	20	GO:0005768
GeneOntologyCellularComponent	endoplasmic reticulum membrane	LMF1 FMO2 ZFYVE27 UGT1A5 TMC6 SEC22B APOB HMGCR FTCD PANX2 ALG10B TMEM260 TMEM259 LPCAT3 ALG10 TMC8 UGT2B4 NDRG4 MAN1B1	3.68e-05	1293	109	19	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	LMF1 FMO2 ZFYVE27 UGT1A5 TMC6 SEC22B APOB HMGCR FTCD PANX2 ALG10B TMEM260 TMEM259 LPCAT3 ALG10 TMC8 UGT2B4 NDRG4 MAN1B1	3.92e-05	1299	109	19	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	LMF1 FMO2 ZFYVE27 UGT1A5 TMC6 SEC22B APOB HMGCR FTCD PANX2 ALG10B TMEM260 TMEM259 LPCAT3 ALG10 TMC8 UGT2B4 NDRG4 MAN1B1	5.23e-05	1327	109	19	GO:0042175
GeneOntologyCellularComponent	endosome membrane	SLC46A2 ZFYVE27 TMEM175 APOB SLC30A3 TMEM106B CLCN3 CLCN5 CLCN6 SBF2 CX3CR1 DOP1B	7.19e-05	602	109	12	GO:0010008
GeneOntologyCellularComponent	Golgi membrane	MANEA SEC22B FTCD PANX2 CLCN3 CLCN5 ST8SIA6 GLCE WSCD2 SMPD3 PAQR3 DOP1A DOP1B	9.76e-05	721	109	13	GO:0000139
GeneOntologyCellularComponent	vacuole	ABCA13 TMEM175 HGSNAT APOB ACE SLC30A3 CRHBP IFNAR1 TMEM106B CLCN3 CLCN5 CLCN6 SBF2 CAP1	2.82e-04	913	109	14	GO:0005773
GeneOntologyCellularComponent	lysosome	ABCA13 TMEM175 HGSNAT APOB ACE SLC30A3 CRHBP IFNAR1 TMEM106B CLCN3 CLCN5 CLCN6 CAP1	3.09e-04	811	109	13	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	ABCA13 TMEM175 HGSNAT APOB ACE SLC30A3 CRHBP IFNAR1 TMEM106B CLCN3 CLCN5 CLCN6 CAP1	3.09e-04	811	109	13	GO:0000323
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	SLC46A2 ZFYVE27 ABCA13 TMC6 TMEM175 HGSNAT SEC22B APOB SLC30A3 SLC32A1 TMEM106B CLCN3 CLCN5 CLCN6 SBF2 CX3CR1 DOP1B	4.21e-04	1307	109	17	GO:0030659
GeneOntologyCellularComponent	late endosome	SLC30A3 CRHBP IFNAR1 TMEM106B CLCN3 CLCN6 RASGEF1B CD79A	4.81e-04	348	109	8	GO:0005770
GeneOntologyCellularComponent	vesicle membrane	SLC46A2 ZFYVE27 ABCA13 TMC6 TMEM175 HGSNAT SEC22B APOB SLC30A3 SLC32A1 TMEM106B CLCN3 CLCN5 CLCN6 SBF2 CX3CR1 DOP1B	4.92e-04	1325	109	17	GO:0012506
GeneOntologyCellularComponent	gap junction	GJB4 PANX2 MIP	9.42e-04	37	109	3	GO:0005921
GeneOntologyCellularComponent	vacuolar membrane	ABCA13 TMEM175 HGSNAT SLC30A3 TMEM106B CLCN3 CLCN5 CLCN6 SBF2	1.35e-03	507	109	9	GO:0005774
GeneOntologyCellularComponent	cation channel complex	CACNA1C HTR3E ABCC9 SLCO6A1 CATSPER1 SCN8A	1.46e-03	235	109	6	GO:0034703
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1C SLCO6A1 CATSPER1	1.78e-03	46	109	3	GO:0005891
GeneOntologyCellularComponent	presynapse	CACNA1C SEC22B SLC30A3 CRHBP SLC32A1 NF1 CLCN3 CLCN5 SCN8A RAB40B CAP1 CNTN1	2.25e-03	886	109	12	GO:0098793
GeneOntologyCellularComponent	CatSper complex	SLCO6A1 CATSPER1	2.71e-03	15	109	2	GO:0036128
GeneOntologyCellularComponent	lysosomal membrane	ABCA13 TMEM175 HGSNAT SLC30A3 TMEM106B CLCN3 CLCN5 CLCN6	2.91e-03	462	109	8	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	ABCA13 TMEM175 HGSNAT SLC30A3 TMEM106B CLCN3 CLCN5 CLCN6	2.91e-03	462	109	8	GO:0098852
Domain	Cl-channel_core	CLCN3 CLCN5 CLCN6	1.58e-05	9	109	3	IPR014743
Domain	-	CLCN3 CLCN5 CLCN6	1.58e-05	9	109	3	1.10.3080.10
Domain	Voltage_CLC	CLCN3 CLCN5 CLCN6	1.58e-05	9	109	3	PF00654
Domain	Cl-channel_volt-gated	CLCN3 CLCN5 CLCN6	1.58e-05	9	109	3	IPR001807
Domain	Alg10	ALG10B ALG10	3.37e-05	2	109	2	IPR016900
Domain	Dopey_N	DOP1A DOP1B	3.37e-05	2	109	2	IPR007249
Domain	DIE2_ALG10	ALG10B ALG10	3.37e-05	2	109	2	PF04922
Domain	Dopey_N	DOP1A DOP1B	3.37e-05	2	109	2	PF04118
Domain	CBS	CLCN3 CLCN5 CLCN6	1.02e-04	16	109	3	SM00116
Domain	CBS_dom	CLCN3 CLCN5 CLCN6	2.05e-04	20	109	3	IPR000644
Domain	CBS	CLCN3 CLCN5 CLCN6	2.05e-04	20	109	3	PF00571
Domain	CBS	CLCN3 CLCN5 CLCN6	2.05e-04	20	109	3	PS51371
Domain	TMC	TMC6 TMC8	9.24e-04	8	109	2	PF07810
Domain	TMC	TMC6 TMC8	9.24e-04	8	109	2	IPR012496
Domain	GRAM	TBC1D9 SBF2	3.84e-03	16	109	2	SM00568
Domain	Aa_trans	SLC32A1 SLC38A6	4.33e-03	17	109	2	PF01490
Domain	AA_transpt_TM	SLC32A1 SLC38A6	4.33e-03	17	109	2	IPR013057
Domain	Channel_four-helix_dom	CACNA1C CATSPER1 SCN8A	4.50e-03	57	109	3	IPR027359
Domain	-	CACNA1C CATSPER1 SCN8A	4.50e-03	57	109	3	1.20.120.350
Pubmed	Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.	CLCN3 CLCN5 CLCN6	1.23e-07	4	110	3	17110406
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN3 CLCN5 CLCN6	6.11e-07	6	110	3	10198195
Pubmed	Functional genetic analysis of mouse chromosome 11.	ALG10B SLC4A1 ALG10 SCN8A	8.01e-07	23	110	4	12955145
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNA1C LMF1 TTC21A TMC6 RNF213 TEP1 FBXO16 FAM120A TSPAN10 PCNX4 LPCAT3 SBF2 NT5C2 RAB40B CNOT1 MAN1B1 DOP1A INVS	9.96e-07	1489	110	18	28611215
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN3 CLCN5 CLCN6	2.55e-06	9	110	3	23115349
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1C ABCC9 CLCN3 CLCN5 CLCN6 SCN8A	5.57e-06	139	110	6	16985003
Pubmed	Ion channel expression in the developing enteric nervous system.	CACNA1C CLCN3 CLCN5 CLCN6	5.77e-06	37	110	4	25798587
Pubmed	Autotomy behavior correlates with the DRG and spinal expression of sodium channels in inbred mouse strains.	SCN8A CNTN1	9.91e-06	2	110	2	19524556
Pubmed	A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels.	APOB HMGCR	9.91e-06	2	110	2	30191727
Pubmed	Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system.	IFNAR1 CX3CR1	9.91e-06	2	110	2	23737750
Pubmed	Partial Protection From Lupus-Like Disease by B-Cell Specific Type I Interferon Receptor Deficiency.	IFNAR1 CD79A	9.91e-06	2	110	2	33488628
Pubmed	MicroRNA-29s suppressed both soluble ST2 release and IFNAR1 expression in human bronchial epithelial cells.	IFNAR1 IL1RL1	9.91e-06	2	110	2	33583067
Pubmed	Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations.	TMC6 TMC8	9.91e-06	2	110	2	26227733
Pubmed	Autosomal dominant epidermodysplasia verruciformis lacking a known EVER1 or EVER2 mutation.	TMC6 TMC8	9.91e-06	2	110	2	19706093
Pubmed	Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis.	TMC6 TMC8	9.91e-06	2	110	2	12426567
Pubmed	EVER proteins, key elements of the natural anti-human papillomavirus barrier, are regulated upon T-cell activation.	TMC6 TMC8	9.91e-06	2	110	2	22761942
Pubmed	Apolipoprotein B and angiotensin-converting enzyme polymorphisms and aerobic interval training: randomized controlled trial in coronary artery disease patients.	APOB ACE	9.91e-06	2	110	2	29846435
Pubmed	Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.	DOP1A DOP1B	9.91e-06	2	110	2	10931277
Pubmed	Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization.	IFNAR1 CX3CR1	9.91e-06	2	110	2	27137488
Pubmed	Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits.	IFNAR1 CX3CR1	9.91e-06	2	110	2	39095477
Pubmed	Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility.	TMC6 TMC8	9.91e-06	2	110	2	21387292
Pubmed	Genetic variations in the epidermodysplasia verruciformis (EVER/TMC) genes, cutaneous human papillomavirus infection and squamous cell carcinoma of the skin.	TMC6 TMC8	9.91e-06	2	110	2	26126409
Pubmed	Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus.	TMC6 TMC8	9.91e-06	2	110	2	25378492
Pubmed	Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25.	TMC6 TMC8	9.91e-06	2	110	2	10844558
Pubmed	Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice.	CLCN3 CLCN5	9.91e-06	2	110	2	38666049
Pubmed	Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth.	NF1 CX3CR1	9.91e-06	2	110	2	21157378
Pubmed	The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.	HMGCR NF1	9.91e-06	2	110	2	16271875
Pubmed	Variants of EVER1 and EVER2 (TMC6 and TMC8) and human papillomavirus status in patients with mucosal squamous cell carcinoma of the head and neck.	TMC6 TMC8	9.91e-06	2	110	2	27097911
Pubmed	Merkel cell polyomavirus detection in a patient with familial epidermodysplasia verruciformis.	TMC6 TMC8	9.91e-06	2	110	2	23535066
Pubmed	Sec22b is a critical and nonredundant regulator of plasma cell maintenance.	SEC22B CD79A	9.91e-06	2	110	2	36595686
Pubmed	TMEM106B regulates microglial proliferation and survival in response to demyelination.	TMEM106B CX3CR1	9.91e-06	2	110	2	37146150
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	CACNA1C SLC32A1 CLCN3 SCN8A	1.28e-05	45	110	4	25979088
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RNF213 NPHP4 WDFY4 TBC1D9 FAM120A GLCE SBF2 WSCD2 DOP1A	2.81e-05	493	110	9	15368895
Pubmed	Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme.	HMGCR NF1	2.97e-05	3	110	2	12409258
Pubmed	The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury.	IL1RL1 CX3CR1	2.97e-05	3	110	2	25661185
Pubmed	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.	APOB NF1	2.97e-05	3	110	2	11727199
Pubmed	Epidermodysplasia verruciformis in lipoid proteinosis: case report and discussion of pathophysiology.	TMC6 TMC8	2.97e-05	3	110	2	23534907
Pubmed	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	ALG10B ALG10	2.97e-05	3	110	2	24303013
Pubmed	Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology.	ABCC9 TMEM106B	2.97e-05	3	110	2	25470345
Pubmed	Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.	CLCN3 CLCN6	2.97e-05	3	110	2	11306429
Pubmed	Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.	SCN8A CNTN1	2.97e-05	3	110	2	20133873
Pubmed	The role of angiotensin-converting enzyme and apolipoprotein-E gene polymorphisms on lipid compositions in newborn infants with intrauterine growth restriction.	APOB ACE	2.97e-05	3	110	2	15223114
Pubmed	Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.	IFNAR1 CX3CR1	2.97e-05	3	110	2	30282022
Pubmed	Support of bone mineral deposition by regulation of pH.	CLCN3 CLCN5	2.97e-05	3	110	2	30044661
Pubmed	The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.	TMC6 TMC8	2.97e-05	3	110	2	30068544
Pubmed	Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.	IFNAR1 CX3CR1	2.97e-05	3	110	2	35443157
Pubmed	Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus.	SLC32A1 CLCN3	2.97e-05	3	110	2	21378974
Pubmed	Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.	IL1RL1 CX3CR1	2.97e-05	3	110	2	32615087
Pubmed	Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.	TMC6 TMC8	2.97e-05	3	110	2	32917726
Pubmed	Type I interferon-activated microglia are critical for neuromyelitis optica pathology.	IFNAR1 CX3CR1	2.97e-05	3	110	2	33241604
Pubmed	A Microbiota-Dependent Subset of Skin Macrophages Protects Against Cutaneous Bacterial Infection.	IFNAR1 CX3CR1	2.97e-05	3	110	2	35757750
Pubmed	Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.	IL1RL1 CX3CR1	2.97e-05	3	110	2	29420261
Pubmed	Population genetic analysis of the genes APOE, APOB(3'VNTR) and ACE in some black and Amerindian communities from Colombia.	APOB ACE	2.97e-05	3	110	2	11359065
Pubmed	Genetic polymorphisms of FAS and EVER genes in a Greek population and their susceptibility to cervical cancer: a case control study.	TMC6 TMC8	2.97e-05	3	110	2	27899077
Pubmed	Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury.	SLC30A3 SLC32A1	2.97e-05	3	110	2	37449644
Pubmed	The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection.	IFNAR1 IL1RL1	2.97e-05	3	110	2	36809763
Pubmed	Five polymorphisms in gene candidates for cardiovascular disease in Afro-Brazilian individuals.	APOB ACE	2.97e-05	3	110	2	15543563
Pubmed	Microglial responses to peripheral type 1 interferon.	IFNAR1 CX3CR1	2.97e-05	3	110	2	33183319
Pubmed	Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15.	SCN8A CNTN1	2.97e-05	3	110	2	7601440
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	DOP1A DOP1B	2.97e-05	3	110	2	16301316
Pubmed	Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.	TMC6 TMC8	2.97e-05	3	110	2	18158319
Pubmed	Pyruvate enhances oral tolerance via GPR31.	GPR31 CX3CR1	2.97e-05	3	110	2	35303081
Pubmed	Genome-wide association study identifies five new schizophrenia loci.	CACNA1C PIK3C2A NT5C2	5.21e-05	23	110	3	21926974
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ABCA13 RNF213 SEC22B CNOT1 DOP1A OTOG	5.44e-05	208	110	6	33230847
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	FMO2 UGT1A5 CLCN6 UGT2B4	5.87e-05	66	110	4	19898482
Pubmed	Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.	NF1 CX3CR1	5.92e-05	4	110	2	29632086
Pubmed	Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.	IFNAR1 CX3CR1	5.92e-05	4	110	2	28959042
Pubmed	PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.	SLC32A1 CX3CR1	5.92e-05	4	110	2	37348508
Pubmed	Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.	CLCN3 CLCN5	5.92e-05	4	110	2	20351103
Pubmed	GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites.	GPR31 CX3CR1	5.92e-05	4	110	2	30675063
Pubmed	The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.	ALG10B ALG10	5.92e-05	4	110	2	14525949
Pubmed	Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.	IL1RL1 CX3CR1	5.92e-05	4	110	2	33108405
Pubmed	Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.	IFNAR1 CX3CR1	5.92e-05	4	110	2	27158906
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	CLCN3 CLCN5 CLCN6	5.94e-05	24	110	3	22534482
Pubmed	Common variants at ten loci influence QT interval duration in the QTGEN Study.	NPHP4 CNOT1 NDRG4	6.73e-05	25	110	3	19305408
Pubmed	Large-scale concatenation cDNA sequencing.	CACNA1C NCAPD3 BTBD2 TBC1D9 NF1 FAM120A CD79A SLC38A6 NDRG4	8.35e-05	568	110	9	9110174
Pubmed	Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain.	ABCC9 PIK3C2A	9.85e-05	5	110	2	9514948
Pubmed	Close linkage of three neuronal genes on distal mouse chromosome 15.	SCN8A CNTN1	9.85e-05	5	110	2	8703126
Pubmed	Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function.	IL1RL1 CX3CR1	9.85e-05	5	110	2	34982959
Pubmed	A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.	CNOT1 NDRG4	9.85e-05	5	110	2	22726844
Pubmed	Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma.	IFNAR1 CX3CR1	9.85e-05	5	110	2	36266311
Pubmed	Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia.	NPHP4 INVS	9.85e-05	5	110	2	20169535
Pubmed	Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.	TMEM259 CX3CR1	9.85e-05	5	110	2	31112137
Pubmed	Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression.	APOB CX3CR1	9.85e-05	5	110	2	25765938
Pubmed	B Cell-Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses.	IFNAR1 CD79A	9.85e-05	5	110	2	30282750
Pubmed	Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau.	APOB ACE	9.85e-05	5	110	2	20570668
Pubmed	Droplet-based forward genetic screening of astrocyte-microglia cross-talk.	IL1RL1 CX3CR1	9.85e-05	5	110	2	36893254
Pubmed	Apoptotic cell fragments locally activate tingible body macrophages in the germinal center.	CD79A CX3CR1	9.85e-05	5	110	2	36868219
Pubmed	Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses.	IFNAR1 CX3CR1	9.85e-05	5	110	2	37414907
Pubmed	USP18 lack in microglia causes destructive interferonopathy of the mouse brain.	IFNAR1 CX3CR1	9.85e-05	5	110	2	25896511
Pubmed	Antimicrobial immunity impedes CNS vascular repair following brain injury.	IFNAR1 CX3CR1	9.85e-05	5	110	2	34556874
Pubmed	An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.	CLCN3 CLCN5	9.85e-05	5	110	2	19339555
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NCAPD3 RNF213 LANCL1 MANEA SEC22B HMGCR TMEM106B NF1 TMEM259 LPCAT3 GLCE TMEM231 MAN1B1	1.11e-04	1201	110	13	35696571
Pubmed	Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.	SCN8A CNTN1	1.47e-04	6	110	2	16029194
Pubmed	Genetic and dietary interactions in the regulation of HMG-CoA reductase gene expression.	APOB HMGCR	1.47e-04	6	110	2	1352323
Pubmed	Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells.	IFNAR1 CX3CR1	1.47e-04	6	110	2	32066949
Pubmed	M cell maturation and cDC activation determine the onset of adaptive immune priming in the neonatal Peyer's patch.	IFNAR1 CX3CR1	1.47e-04	6	110	2	37130522
Pubmed	L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.	CACNA1C MIP	1.47e-04	6	110	2	23734214
Pubmed	Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells.	IFNAR1 CX3CR1	1.47e-04	6	110	2	33773107
Pubmed	Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.	CACNA1C CMKLR2 NT5C2	1.87e-04	35	110	3	22688191
Cytoband	17q25.3	TMC6 RNF213 TSPAN10 TMC8 RAB40B	4.75e-06	101	110	5	17q25.3
GeneFamily	Chloride voltage-gated channels	CLCN3 CLCN5 CLCN6	7.12e-06	10	72	3	302
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10B ALG10	1.56e-05	2	72	2	448
GeneFamily	Solute carriers	SLC46A2 SLC30A3 SLCO6A1 SLC4A1 SLC32A1 SLC10A6 SLC38A6 SLC25A45	1.71e-04	395	72	8	752
GeneFamily	Transmembrane channel likes	TMC6 TMC8	4.31e-04	8	72	2	1135
GeneFamily	G protein-coupled receptors, Class A orphans	CMKLR2 GPR17 GPR31	3.72e-03	78	72	3	262
ToppCell	10x5'-GI_large-bowel-Mast\|GI_large-bowel / Manually curated celltypes from each tissue	CATSPER1 ST8SIA6 TSPAN10 CCNA1 IL1RL1 LRMDA	5.37e-06	178	110	6	d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell	10x5'-GI_large-bowel-Mast-Mast_cells\|GI_large-bowel / Manually curated celltypes from each tissue	CATSPER1 ST8SIA6 TSPAN10 CCNA1 IL1RL1 LRMDA	5.37e-06	178	110	6	8fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell	droplet-Marrow-BM-30m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAPD3 SLC4A1 MEMO1 LPCAT3 FBXO7 IL1RL1	7.34e-06	188	110	6	f1a9d8ea174a4bef0fae8188e3bd96b7ac1a39bb
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9 MANEA ACE TBC1D9 ZBTB11 INVS	9.04e-06	195	110	6	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CMKLR2 FKBP6 RNF213 SBF2 CX3CR1	2.07e-05	134	110	5	3b67c02b430b6d58467f36e606c478d3eea0063f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF831 SLC30A3 SLCO6A1 RAB40B CX3CR1	2.83e-05	143	110	5	57ee1830d96d73d92b5f83b028592a5d952c6013
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Fibroblasts-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC30A3 SLCO6A1 CENPI RAB40B CX3CR1	3.67e-05	151	110	5	f13a117ae26ae525da4f3e837d8f204d00dc6ee3
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZNF831 FBXO16 WSCD2 RAB40B SMPD3	4.84e-05	160	110	5	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZNF831 FBXO16 WSCD2 RAB40B SMPD3	4.98e-05	161	110	5	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF831 NPHP4 PIK3C2A CD79A CNTN1	5.76e-05	166	110	5	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF831 NPHP4 PIK3C2A CD79A CNTN1	5.76e-05	166	110	5	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	Ciliated_cells-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	TTC21A DNAH12 UGT2B4 KCTD15 TMEM231	5.76e-05	166	110	5	4b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	LINGO2 ST8SIA6 WSCD2 IL1RL1 PAQR3	6.27e-05	169	110	5	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 ABCA13 TTC21A DNAH12 TMEM231	6.27e-05	169	110	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 SAMD9 ADPRM TMC8 CX3CR1	6.45e-05	170	110	5	28fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NCAPD3 SAMD9 ADPRM TMC8 CX3CR1	6.45e-05	170	110	5	239cb4b801b2d71a6facb386f2684c0851504151
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	LINGO2 ST8SIA6 WSCD2 IL1RL1 PAQR3	6.45e-05	170	110	5	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEP1 WDFY4 TBC1D9 ST8SIA6 IL1RL1	6.45e-05	170	110	5	6686d1797988216c0d9417f21a2537369abce410
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	LMF1 CD79A SMPD3 SCAI DOP1B	6.63e-05	171	110	5	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMTM3 TEP1 WDFY4 TBC1D9 IL1RL1	6.63e-05	171	110	5	0385d5834ae16bbb0c6a68893fec60e4dd1e478d
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMTM3 TEP1 WDFY4 TBC1D9 IL1RL1	6.63e-05	171	110	5	a3e3fe0cbab21abb178c482f5951e576529f7e30
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEP1 WDFY4 TBC1D9 ST8SIA6 IL1RL1	6.82e-05	172	110	5	cabe7b4131d72da87d3caacd8cced3a4f2cbef53
ToppCell	10x5'-GI_small-bowel-Mast\|GI_small-bowel / Manually curated celltypes from each tissue	CATSPER1 ST8SIA6 WSCD2 IL1RL1 LRMDA	7.20e-05	174	110	5	e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCell	10x5'-GI_small-bowel-Mast-Mast_cells\|GI_small-bowel / Manually curated celltypes from each tissue	CATSPER1 ST8SIA6 WSCD2 IL1RL1 LRMDA	7.20e-05	174	110	5	05525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Mast_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMTM3 ASCC1 CATSPER1 IL1RL1 LRMDA	7.60e-05	176	110	5	0d203682c372411ba64e97a8eae6c4788e8b6ecf
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEP1 WDFY4 TBC1D9 ST8SIA6 IL1RL1	7.60e-05	176	110	5	a85ad8b4815fde72edd5c900e882a0bc04033ea8
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	LMF1 ASCC1 TMEM106B CLCN6 TMEM231	7.81e-05	177	110	5	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMGCR WDFY4 CATSPER1 TMC8 IL1RL1	7.81e-05	177	110	5	15553c7cd7826c80086daa76af4224f32dde53a6
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TTC21A WDFY4 CRHBP DNAH12 CD79A	8.02e-05	178	110	5	812e261d9cbdc74fafe3c5c3422151c1cfacb22d
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CATSPER1 ST8SIA6 TMC8 CCNA1 IL1RL1	8.45e-05	180	110	5	1c5515f29ead129bee3b4ca27799796956811a39
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	TEP1 ALG10B CLCN6 ALG10 MAN1B1	9.37e-05	184	110	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	TEP1 ALG10B CLCN6 ALG10 MAN1B1	9.61e-05	185	110	5	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	COVID-19-T_cells-NK_cells\|COVID-19 / group, cell type (main and fine annotations)	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.06e-04	189	110	5	b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CRHBP ST8SIA6 PIK3C2A LRMDA NDRG4	1.09e-04	190	110	5	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	COVID-19-kidney-NK\|kidney / Disease (COVID-19 only), tissue and cell type	SAMD9 ZNF831 ST8SIA6 TMC8 CX3CR1	1.09e-04	190	110	5	e3ca3c9fb9e27670a5dd128dd6564ff98a57159e
ToppCell	COVID-19-Heart-T_cell\|Heart / Disease (COVID-19 only), tissue and cell type	ABCA13 LINGO2 ZNF831 SLC4A1 TMC8	1.09e-04	190	110	5	e6c3a6e01fef6c5b49f72661d4fb0414ba9046bf
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	RNF213 HMGCR ALG10 INVS DOP1B	1.12e-04	191	110	5	9454f642c3621370fa23640b631301346b300950
ToppCell	Adult-Immune-natural_killer_cell\|Adult / Lineage, Cell type, age group and donor	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.12e-04	191	110	5	758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.12e-04	191	110	5	6345c1aa0fd2f9f2154a44f9393bf7c72bb1f44e
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-T_reg\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF831 CENPI TMC8 SMPD3 SLC25A45	1.14e-04	192	110	5	94e11f68767a899cbcc6984f9398877c1e464abc
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.17e-04	193	110	5	1cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FKBP6 NWD1 ABCA13 DNAH12 TMEM231	1.20e-04	194	110	5	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.23e-04	195	110	5	649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.23e-04	195	110	5	79dc031258579ea328181dda33710dd897f1064a
ToppCell	COVID-19-lung-NK/NKT\|lung / Disease (COVID-19 only), tissue and cell type	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.23e-04	195	110	5	3ab941a369e3815f338890b116dc77aefa054098
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.23e-04	195	110	5	129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.23e-04	195	110	5	3e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C LINGO2 SCN8A CNTN1 SCAI	1.26e-04	196	110	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Striatum-Neuronal-Excitatory\|Striatum / BrainAtlas - Mouse McCarroll V32	ZNF831 WSCD2 RAB40B SMPD3 NDRG4	1.26e-04	196	110	5	67400193ba469cf4d939e94f5ed94995e384bc07
ToppCell	distal-3-Epithelial-Proximal_Ciliated\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NWD1 ABCA13 DNAH12 CCNA1 TMEM231	1.29e-04	197	110	5	15b4d1203943ce90a7083178d4a4284d9b323071
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WDFY4 TBC1D9 TMC8 WSCD2 CD79A	1.29e-04	197	110	5	e4b4fa219322b3250b482f8e242f41e8b05485db
ToppCell	(06)_Krt4/13+-(2)_48hpi\|(06)_Krt4/13+ / shred by cell type and Timepoint	ADPRM CLCN3 NT5C2	1.32e-04	40	110	3	1e42cd186ee06ac9345e16ede649a72c15bdf2f8
ToppCell	3'_v3-GI_small-bowel-Mast-Mast_cells\|GI_small-bowel / Manually curated celltypes from each tissue	CATSPER1 CLCN3 ST8SIA6 IL1RL1 LRMDA	1.32e-04	198	110	5	920d2e6603a06c2e8dcb6be127202d222c662bca
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C SCN8A NDRG4 CNTN1 SCAI	1.32e-04	198	110	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	3'_v3-GI_small-bowel-Mast\|GI_small-bowel / Manually curated celltypes from each tissue	CATSPER1 CLCN3 ST8SIA6 IL1RL1 LRMDA	1.32e-04	198	110	5	807e3ed34739eca159dd0970f884b073e588c649
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINGO2 ST8SIA6 TMC8 IL1RL1 PAQR3	1.38e-04	200	110	5	9156f8fd61a833891d2f7b7fadd693b81b1e2d5a
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINGO2 ST8SIA6 TMC8 IL1RL1 PAQR3	1.38e-04	200	110	5	566fe2e78e6f35399ec6aad5964f6d4d8ade82c6
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1C LINGO2 SCN8A CNTN1 SCAI	1.38e-04	200	110	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.38e-04	200	110	5	7d90fcb5dfc4c9d562c93b0f9293ed12b5f4f404
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.38e-04	200	110	5	d2422aaf807010194994db97142b9fd2e807312d
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.38e-04	200	110	5	0f8e2fed93cc103b20a825d8d3e83787c5c015cc
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.38e-04	200	110	5	ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Ciliated\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.38e-04	200	110	5	a521cf837cadf280505ff9d7e641a205af7d6513
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NWD1 ABCA13 TTC21A DNAH12 TMEM231	1.38e-04	200	110	5	918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LINGO2 ZNF831 ST8SIA6 TMC8 CX3CR1	1.38e-04	200	110	5	1d2ee63010b7b8b38bea7d3b30eebfbcdd18b967
Disease	Calcium channel blocker use measurement	CACNA1C RNF213 ZNF831 ACE CLCN6 SBF2 NT5C2 MTX1	1.14e-06	213	107	8	EFO_0009930
Disease	EPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 1	TMC6 TMC8	1.30e-05	2	107	2	C4722564
Disease	coronary artery disease (is_implicated_in)	APOB HMGCR ACE CLCN6 IL1RL1	3.27e-05	100	107	5	DOID:3393 (is_implicated_in)
Disease	Long Qt Syndrome 2	ALG10B ALG10	3.90e-05	3	107	2	C3150943
Disease	Dent disease (implicated_via_orthology)	CLCN3 CLCN5	3.90e-05	3	107	2	DOID:0050699 (implicated_via_orthology)
Disease	Coronary heart disease	APOB ACE CX3CR1	8.88e-05	24	107	3	C0010068
Disease	Depressive Symptoms	ABCC9 ACE IFNAR1	1.13e-04	26	107	3	C0086132
Disease	epidermodysplasia verruciformis (is_implicated_in)	TMC6 TMC8	1.29e-04	5	107	2	DOID:13777 (is_implicated_in)
Disease	neuronal ceroid lipofuscinosis 3 (implicated_via_orthology)	CLCN3 CLCN6	1.29e-04	5	107	2	DOID:0110731 (implicated_via_orthology)
Disease	Epidermodysplasia Verruciformis	TMC6 TMC8	1.29e-04	5	107	2	C0014522
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10B ALG10	1.94e-04	6	107	2	DOID:0050563 (implicated_via_orthology)
Disease	osteopetrosis (implicated_via_orthology)	CLCN3 CLCN5	2.70e-04	7	107	2	DOID:13533 (implicated_via_orthology)
Disease	Meckel syndrome (implicated_via_orthology)	NPHP4 TMEM231	3.60e-04	8	107	2	DOID:0050778 (implicated_via_orthology)
Disease	Hypercholesterolemia	LMF1 APOB HMGCR	3.85e-04	39	107	3	C0020443
Disease	lipoprotein-associated phospholipase A(2) measurement	RNF213 APOB GLCE	4.15e-04	40	107	3	EFO_0004746
Disease	Nephronophthisis	NPHP4 INVS	4.61e-04	9	107	2	cv:C0687120
Disease	nephronophthisis (implicated_via_orthology)	TTC21A NPHP4	4.61e-04	9	107	2	DOID:12712 (implicated_via_orthology)
Disease	bipolar disorder, schizophrenia	CACNA1C PIK3C2A WSCD2	4.80e-04	42	107	3	MONDO_0004985, MONDO_0005090
Disease	Shortened QT interval	CACNA1C ABCC9	7.01e-04	11	107	2	C0151879
Disease	Renal dysplasia and retinal aplasia (disorder)	NPHP4 INVS	8.40e-04	12	107	2	C0403553
Disease	sialate O-acetylesterase measurement	LINGO2 BTBD2	8.40e-04	12	107	2	EFO_0803073
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	APOB HMGCR SLC30A3	8.51e-04	51	107	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	Hyperlipoproteinemia Type IIb	APOB HMGCR	9.90e-04	13	107	2	C1704417
Disease	Nephronophthisis	NPHP4 INVS	9.90e-04	13	107	2	C0687120
Disease	hip bone mineral density, hip bone size	LINGO2 ALG10B TMEM260	1.12e-03	56	107	3	EFO_0004844, EFO_0007702
Disease	obsolete_red blood cell distribution width	SAMD9 TMC6 APOB SLC4A1 CDH24 CLCN6 ST8SIA6 TMEM259 LPCAT3 TMC8 FBXO7 NT5C2 PAQR3	1.19e-03	1347	107	13	EFO_0005192
Disease	cocaine dependence	LINGO2 RASGEF1B CCNA1	1.24e-03	58	107	3	EFO_0002610
Disease	Down syndrome (implicated_via_orthology)	DOP1A DOP1B	1.33e-03	15	107	2	DOID:14250 (implicated_via_orthology)
Disease	Hypertriglyceridemia	LMF1 APOB	1.33e-03	15	107	2	C0020557
Disease	Hyperlipoproteinemia Type IIa	APOB HMGCR	1.51e-03	16	107	2	C0745103
Disease	Moyamoya Disease	RNF213 NF1	1.71e-03	17	107	2	C0026654
Disease	glomerulonephritis (implicated_via_orthology)	ACE CX3CR1	1.71e-03	17	107	2	DOID:2921 (implicated_via_orthology)
Disease	hip bone size	LINGO2 ALG10B TMEM260	1.72e-03	65	107	3	EFO_0004844
Disease	diverticular disease	STN1 SLC4A1 IFNAR1 NF1 UGT2B4	1.72e-03	236	107	5	EFO_0009959
Disease	myocardial infarction	APOB HMGCR ZNF831 STN1 TMEM106B RASGEF1B	1.77e-03	350	107	6	EFO_0000612
Disease	Hypercholesterolemia, Familial	APOB HMGCR	1.92e-03	18	107	2	C0020445
Disease	fatty acid measurement, linoleic acid measurement	LINGO2 HMGCR LPCAT3	1.96e-03	68	107	3	EFO_0005110, EFO_0006807
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	APOB HMGCR SLC30A3	2.04e-03	69	107	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	IGF-1 measurement	LMF1 ASCC1 LINGO2 SLC30A3 FAM120A SCAI DOP1B	2.04e-03	488	107	7	EFO_0004627
Disease	Malignant Glioma	NF1 CLCN3 CLCN5	2.13e-03	70	107	3	C0555198
Disease	mixed gliomas	NF1 CLCN3 CLCN5	2.13e-03	70	107	3	C0259783
Disease	stomach cancer (is_implicated_in)	TEP1 ACE TMEM260	2.31e-03	72	107	3	DOID:10534 (is_implicated_in)
Disease	mean arterial pressure	RNF213 ZNF831 SLCO6A1 STN1 CLCN6 NT5C2 MTX1	2.31e-03	499	107	7	EFO_0006340
Disease	end stage renal disease (implicated_via_orthology)	HMGCR ACE	2.37e-03	20	107	2	DOID:783 (implicated_via_orthology)
Disease	androsterone glucuronide measurement	MEMO1 UGT2B4	2.37e-03	20	107	2	EFO_0800317
Disease	erythrocyte measurement	TMC6 SLC4A1 LPCAT3 FBXO7 NT5C2	2.49e-03	257	107	5	EFO_0005047
Disease	asthma (is_implicated_in)	HMGCR ACE IL1RL1 CX3CR1	2.60e-03	157	107	4	DOID:2841 (is_implicated_in)
Disease	Nephritis, Tubulointerstitial	SLC4A1 CLCN5	2.62e-03	21	107	2	C0041349
Disease	tissue factor measurement	UGT1A5 CNTN1	2.62e-03	21	107	2	EFO_0010623
Disease	nephrosis (biomarker_via_orthology)	ACE CX3CR1	2.87e-03	22	107	2	DOID:2527 (biomarker_via_orthology)
Disease	preeclampsia	ZNF831 CLCN6 INVS	2.90e-03	78	107	3	EFO_0000668
Disease	generalized anxiety disorder	TMEM106B FAM120A	3.14e-03	23	107	2	EFO_1001892
Disease	hippocampal sclerosis of aging	ABCC9 TMEM106B	3.14e-03	23	107	2	EFO_0005678
Disease	Nephritis, Interstitial	SLC4A1 CLCN5	3.41e-03	24	107	2	C0027707
Disease	airway responsiveness measurement	LINGO2 WDFY4	3.41e-03	24	107	2	EFO_0006897
Disease	Brugada Syndrome (disorder)	CACNA1C ABCC9	3.41e-03	24	107	2	C1142166

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLKIIALGLSYFFDF	CATSPER1	496	Q8NEC5
SYFDLILVDARKPLF	NT5C2	281	P49902
ALDKIAFIPFSYLVD	ACE	1056	P12821
LAAVIFIYFAALSPA	SLC4A1	406	P02730
LVAIDALSFYLPVKS	HTR3E	261	A5X5Y0
LFASFYLLDFILALV	GPR17	61	Q13304
LLLAACLPFLAAFYL	GPR31	61	O00270
AFDSLLAGPVAEYLK	CAP1	46	Q01518
YLPEFLHTFKITALL	ABCA13	3206	Q86UQ4
PKFRFILLDAYDLSV	ADPRM	156	Q3LIE5
LKSFALLPRLEYNDA	ASCC1	346	Q8N9N2
IFLETLKLYDFFPSC	CX3CR1	251	P49238
KDLFLYSSGLFPLLA	DOP1A	101	Q5JWR5
FLNSALRATAPYKFL	GLCE	466	O94923
ETSNFPKLLLALFLY	ABCC9	126	O60706
PFAEFRKILQFLLAY	ALG10B	226	Q5I7T1
LPATIFLLFLLSAVY	CD79A	11	P11912
LFLYECATSKAFPLE	NWD1	1371	Q149M9
SLLYDFLLFPRLKSI	MIP	216	P30301
SPVRAYDFLLKFLLV	RAB40B	6	Q12829
IALLAFLFYISKVPE	PAQR3	246	Q6TCH7
FSRILDKSLPADILY	HINT2	56	Q9BX68
CFVLYKLPNLKFLDA	LRMDA	106	Q9H2I8
YFLADLLVPTKARFP	LANCL1	381	O43813
AAALLPLTSAFYRKL	SBF2	631	Q86WG5
LSLALLLAVKYIFFE	HMGCR	326	P04035
KDLFLYSCGLFPLLA	DOP1B	101	Q9Y3R5
AKLVYTVLDGLPFFS	CDH24	186	Q86UP0
ALFALPFVIYAAKVF	IFNAR1	446	P17181
PELFQLALKAFRYTL	PCNX4	1016	Q63HM2
ALYPLIALELLDSKF	PIK3C2A	936	O00443
FLMDLSITYAKPLLF	DNAH12	1876	Q6ZR08
FFLSLLFILPYIHKA	LPCAT3	461	Q6P1A2
LSTVPFLAFKHLVYL	LINGO2	261	Q7L985
LDAFLAQALSPKLYE	FAM120A	736	Q9NZB2
HLDKYLAIFDAFITP	OR4F15	266	Q8NGB8
IYLALLVASLPFAFL	SMPD3	66	Q9NY59
IPFFSLLIKDIYFLN	RASGEF1B	371	Q0VAM2
LKLFCDKYNLIFIPS	MANEA	341	Q5SRI9
KYLFLLFSDDPNLLS	MAN1B1	666	Q9UKM7
LDDLFFTLYPSLEKF	NPHP4	241	O75161
AAKLPVLLNLSFTYL	FKBP6	216	O75344
QLYSKFLLKAEPLAF	APOB	1926	P04114
SPVTLALFFVLYFLL	CLCN6	461	P51797
LLKFLPAAVADSGIY	IL1RL1	71	Q01638
AALKDYALLTLPAEF	HEATR5B	1486	Q9P2D3
FIKSFQALPYVALLI	CACNA1C	1401	Q13936
AADYDPFLLFSANLK	CRHBP	31	P24387
RLFKDQLVYPLLAFT	FBXO7	306	Q9Y3I1
ADPFLKYLPSLIAAA	CCNA1	376	P78396
KYLPSLIAAAAFCLA	CCNA1	381	P78396
AFLAVSLVKVFAPYA	CLCN5	221	P51795
YANAELKILALAPTF	CNTN1	401	Q12860
YLLSLIFKAAVDAGF	GJB4	131	Q9NTQ9
FVLLKALFVLFVLAY	TMEM259	71	Q4ZIN3
SLLFKDPKLAVRLYF	FMO2	451	Q99518
SFAFFILLVLYPVVD	HGSNAT	576	Q68CP4
KLPRVLSLYIFSFLD	FBXO16	91	Q8IX29
QALLSLYKFFAPALI	CENPI	236	Q92674
VEPAAFLALLKFLYS	BTBD2	166	Q9BX70
YLVLCEAAFPKKLAF	SEC22B	71	O75396
GLVPLKALLDAAAFY	FTCD	271	O95954
PSLFEHKFLPYALLA	PANX2	116	Q96RD6
IFIYARPKALSAFDT	OR6A2	261	O95222
YLDAIKLLLDFAAFP	INVS	501	Q9Y283
PADIVSFLLTAALYK	OTOG	1286	Q6ZRI0
KLFSKYLADPSNLFV	MEMO1	171	Q9Y316
PVYFFLKNLSFLDLC	OR14A16	56	Q8NHC5
VLFLSTGFIAYLKPA	OR14A16	246	Q8NHC5
FVFSYLALLLQAKLP	MTX1	351	Q13505
FYLLKIASFSSPAFL	TAS2R13	106	Q9NYV9
LAVFFLFPRSIDVKY	TMEM106B	111	Q9NUM4
PVFLAFAKLYIRDIL	STN1	21	Q9H668
KLFSFLALLNSYVPD	SAMD9	916	Q5K651
PGLFYLKLSREDFLS	SLC38A6	411	Q8IZM9
AATKPDLPTYLLLFF	SMIM32	46	A0A1B0GUA5
VLFFHPKYLKDLALF	ST8SIA6	296	P61647
YKLPLFIAFIFSTLI	SLCO6A1	576	Q86UG4
GAYVLAKFALIFPDL	NDRG4	116	Q9ULP0
PFAEFRKILQFLLAY	ALG10	226	Q5BKT4
IADFIFLLFLPLYIS	CMKLR2	81	P46091
AFLTAPLLEFLLALY	CMTM3	66	Q96MX0
LAAFTKLYESLLPFA	NCAPD3	51	P42695
FAFLAVSLVKVFAPY	CLCN3	221	P51790
LFKYLAPFLRNVELT	CNOT1	2071	A5YKK6
LLKFYELPALSAEIV	RNF213	861	Q63HN8
FCKASFLPLLEFAYT	ZBTB11	261	O95625
PLLNSVFLFLTFYIK	TMC8	496	Q8IU68
AKLALYPCASLLAFA	TMEM175	421	Q9BSA9
ALLEPEFILKASLYA	TEP1	281	Q99973
FLQAYCLAPFDLIKV	SLC25A45	111	Q8N413
AELLKIPFVYSLRFS	UGT2B4	161	P06133
KLLLPDDFKDFSLLY	KCTD15	121	Q96SI1
FLASLLTEPALVKYF	TBC1D9	1216	Q6ZT07
LYLFFVFPLDKDELL	WDFY4	171	Q6ZS81
VLALKLLLYFLASPS	WDFY4	1641	Q6ZS81
LAKYLSIPAVFFLRN	UGT1A5	161	P35504
LSLTEFSLPKFYLLF	NF1	2151	P21359
LYTFLAASFKELPAN	SCAI	346	Q8N9R8
KTLFRFSATPALYIL	SCN8A	101	Q9UQD0
FTAYLLAISFSLKPV	SLC10A6	81	Q3KNW5
VPALLALAQAYVFLK	TTC21A	1161	Q8NDW8
SFGVLAASILIYFKP	SLC30A3	246	Q99726
VKYLIFLSNFPFSLL	TSPAN10	76	Q9H1Z9
KSPAFDLFNLVLSYK	ZFYVE27	31	Q5T4F4
SKAALFLLLAAALTY	TMEM231	21	Q9H6L2
ASFALLYSLLVLKVP	SLC46A2	216	Q9BY10
LSYFLFLKTLLAFNA	TMC6	246	Q7Z403
LVAKALLSYPLPFFA	SLC32A1	386	Q9H598
FDAAILLIRNPYKAL	WSCD2	411	Q2TBF2
ALADNAFSPKYLLRL	ZNF831	931	Q5JPB2
YPLFTLVAKLAITLF	TMEM260	71	Q9NX78
LLKALAFVYFVAFLV	LMF1	56	Q96S06