Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3 SBF2 HERC1 C9orf72	9.49e-06	231	149	10	GO:0005085
Domain	GDS_CDC24_CS	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1	5.88e-07	39	148	6	IPR001331
Domain	DH_1	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	6.50e-07	63	148	7	PS00741
Domain	RhoGEF	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	1.34e-06	70	148	7	PF00621
Domain	DH_2	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	1.34e-06	70	148	7	PS50010
Domain	-	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	1.48e-06	71	148	7	1.20.900.10
Domain	DH-domain	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	1.48e-06	71	148	7	IPR000219
Domain	TF_AP2	TFAP2D TFAP2A TFAP2B	4.82e-06	5	148	3	IPR004979
Domain	TF_AP2_C	TFAP2D TFAP2A TFAP2B	4.82e-06	5	148	3	IPR013854
Domain	TF_AP-2	TFAP2D TFAP2A TFAP2B	4.82e-06	5	148	3	PF03299
Domain	RhoGEF	OBSCN ARHGEF12 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	1.63e-05	68	148	6	SM00325
Domain	Asp/Glu/Uridylate_kinase	NAGS ALDH18A1	6.24e-05	2	148	2	IPR001048
Domain	Cohesin_HEAT	INTS4 NIPBL	6.24e-05	2	148	2	PF12765
Domain	-	NAGS ALDH18A1	6.24e-05	2	148	2	3.40.1160.10
Domain	Cohesin_HEAT	INTS4 NIPBL	6.24e-05	2	148	2	IPR026003
Domain	RGS-like_dom	ARHGEF12 ARHGEF11	1.86e-04	3	148	2	IPR015212
Domain	RGS-like	ARHGEF12 ARHGEF11	1.86e-04	3	148	2	PF09128
Domain	FRG2	FRG2 FRG2B	1.86e-04	3	148	2	PF15315
Domain	FRG2	FRG2 FRG2B	1.86e-04	3	148	2	IPR026245
Domain	PH	OBSCN ARHGEF12 GRB10 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3 SBF2	3.81e-04	278	148	9	SM00233
Domain	PH_DOMAIN	OBSCN ARHGEF12 GRB10 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3 SBF2	3.91e-04	279	148	9	PS50003
Domain	PH_domain	OBSCN ARHGEF12 GRB10 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3 SBF2	4.01e-04	280	148	9	IPR001849
Domain	FN3	COL6A3 OBSCN TIE1 PTPRK TNR EPHA3 MYBPC2	6.90e-04	185	148	7	SM00060
Domain	RCC1/BLIP-II	ALS2 TECPR2 HERC1	7.69e-04	23	148	3	IPR009091
Domain	PDZ	PDLIM7 ARHGEF12 ARHGEF11 CYTIP TIAM1 SCRIB	9.12e-04	141	148	6	PF00595
Domain	FN3	COL6A3 OBSCN TIE1 PTPRK TNR EPHA3 MYBPC2	1.06e-03	199	148	7	PS50853
Domain	-	LDLRAP1 OBSCN ARHGEF12 GRB10 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3 SBF2	1.13e-03	391	148	10	2.30.29.30
Domain	PDZ	PDLIM7 ARHGEF12 ARHGEF11 CYTIP TIAM1 SCRIB	1.17e-03	148	148	6	SM00228
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2D TFAP2A TFAP2B EP300	1.19e-06	11	112	4	MM15510
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2D TFAP2A TFAP2B EP300	1.78e-06	12	112	4	M27765
Pathway	REACTOME_CDC42_GTPASE_CYCLE	PAK4 WDR81 ARHGEF12 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3 SCRIB	3.22e-05	155	112	8	M41808
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2D TFAP2A TFAP2B	3.96e-05	9	112	3	MM15509
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2D TFAP2A TFAP2B EP300	4.93e-05	26	112	4	MM15502
Pathway	REACTOME_NEGATIVE_REGULATION_OF_ACTIVITY_OF_TFAP2_AP_2_FAMILY_TRANSCRIPTION_FACTORS	TFAP2D TFAP2A TFAP2B	5.63e-05	10	112	3	M27764
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	TFAP2D TFAP2A TFAP2B EP300	2.26e-04	38	112	4	M27757
Pathway	REACTOME_RHO_GTPASE_CYCLE	PAK4 OBSCN WDR81 ARHGEF12 ALS2 ARHGEF11 ITGB1 PLEKHG1 TIAM1 PLEKHG3 SAMM50 SCRIB	2.38e-04	450	112	12	M27078
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PDLIM7 PAK4 SMPD4 CEP192 EYA2 ITGB1 TFAP2A PHF2 PACS1 PTPN9 UBA1 C1orf226 TIAM1 PMPCA PTPRK SBF2 INTS4 ALDH18A1 SCRIB HERC1	2.90e-08	1049	150	20	27880917
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 ZNF536 SENP3 DNAH2 FARSB LANCL1 TFAP2A DAP3 LIG3 PTPN9 PHACTR3 NIPBL EP300 PCK2 ACSS3	1.27e-07	638	150	15	31182584
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RPF1 ZNF487 TCAF1 ERCC5 PAK4 OBSCN PEX1 FARSB ALS2 CEP192 ANKRD6 ITGB1 PACS1 SBF2 ADAMTS18 ACIN1 ITPRIP TMEM131 HERC1	2.42e-07	1084	150	19	11544199
Pubmed	Expression of Tfap2d, the gene encoding the transcription factor Ap-2 delta, during mouse embryogenesis.	TFAP2D TFAP2A TFAP2B	3.14e-07	4	150	3	12711551
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	SMARCA5 EPPK1 ESS2 ARHGAP36 PAK4 ARHGEF12 LANCL1 ALS2 ARHGEF11 SERPINH1 ADAR PLEKHG1 UBA1 TIAM1 PLEKHG3 ALDH18A1 SCRIB	4.98e-07	916	150	17	32203420
Pubmed	Analysis of transcription factor AP-2 expression and function during mouse preimplantation development.	TFAP2D TFAP2A TFAP2B	7.81e-07	5	150	3	16672719
Pubmed	AP-2α and AP-2β regulate dorsal interneuron specification in the spinal cord.	TFAP2D TFAP2A TFAP2B	7.81e-07	5	150	3	27984181
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CUL1 ZNF536 SMARCA5 ESS2 SENP3 FARSB SMPD4 CPS1 ADAR ITGB1 TFAP2A SART1 LIG3 ZBTB21 SCRIB EP300	1.02e-06	857	150	16	25609649
Pubmed	Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus.	TFAP2D TFAP2A TFAP2B	1.56e-06	6	150	3	27259519
Pubmed	Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.	TFAP2A TFAP2B EP300	1.56e-06	6	150	3	12586840
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 SMARCA5 PDLIM7 SENP3 FARSB LANCL1 SERPINH1 ADAR DDX10 SART1 LIG3 UBA1 PLEKHG3 FHOD1 ALDH18A1 ACIN1 SAMM50 SCRIB NIPBL PCK2	1.62e-06	1353	150	20	29467282
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PALD1 ZNF536 ARHGEF12 GRB10 ALS2 CEP192 ADCY6 PLEKHG1 STARD9 ACIN1 SCRIB	1.71e-06	407	150	11	12693553
Pubmed	Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb.	TFAP2D TFAP2A TFAP2B	2.72e-06	7	150	3	14572467
Pubmed	AP-2ε Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells.	TFAP2D TFAP2A TFAP2B	2.72e-06	7	150	3	29467543
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 SMG1 SPAG1 SMARCA5 HNRNPCL1 ERCC5 DNAH2 GRIA4 LRRC43 ADCY6 SART1 DAP3 PRDM8 TESMIN PMPCA STARD9 ZBTB21 ACIN1 NIPBL MYBPC2	4.23e-06	1442	150	20	35575683
Pubmed	Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.	TFAP2A TFAP2B EP300	4.33e-06	8	150	3	11744733
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CUL1 LDLRAP1 SMARCA5 EPPK1 PDLIM7 SENP3 PAK4 SART1 FHOD1 ACIN1 SCRIB NIPBL	9.16e-06	582	150	12	20467437
Pubmed	Conditional Deletion of AP-2α and AP-2β in the Developing Murine Retina Leads to Altered Amacrine Cell Mosaics and Disrupted Visual Function.	TFAP2A TFAP2B	1.85e-05	2	150	2	29715367
Pubmed	A human specific Alu DNA cassette is found flanking the genes of transcription factor AP2.	TFAP2D TFAP2B	1.85e-05	2	150	2	30975199
Pubmed	AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis.	TFAP2A TFAP2B	1.85e-05	2	150	2	38237728
Pubmed	Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.	ARHGEF12 ARHGEF11	1.85e-05	2	150	2	24106280
Pubmed	Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.	PAK4 ARHGEF11	1.85e-05	2	150	2	14625312
Pubmed	Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties.	TFAP2D TFAP2A	1.85e-05	2	150	2	11522791
Pubmed	Beta 1 integrin-mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell proliferation and differentiation in vitro.	ITGB1 TNR	1.85e-05	2	150	2	18658130
Pubmed	Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface.	TFAP2A TFAP2B	1.85e-05	2	150	2	12694203
Pubmed	Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate.	TFAP2A DNMT3A	1.85e-05	2	150	2	27906176
Pubmed	Cloning and characterization of a second AP-2 transcription factor: AP-2 beta.	TFAP2A TFAP2B	1.85e-05	2	150	2	7555706
Pubmed	Comparative analysis of AP-2 alpha and AP-2 beta gene expression during murine embryogenesis.	TFAP2A TFAP2B	1.85e-05	2	150	2	8989526
Pubmed	PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells.	PAK4 ARHGEF11	1.85e-05	2	150	2	27765920
Pubmed	Functional Divergence of Mammalian TFAP2a and TFAP2b Transcription Factors for Bidirectional Sleep Control.	TFAP2A TFAP2B	1.85e-05	2	150	2	32769099
Pubmed	AP2 transcription factor induces apoptosis in retinoblastoma cells.	TFAP2A TFAP2B	1.85e-05	2	150	2	20607706
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TCAF1 HCN4 SENP3 WDR81 ARHGEF12 FARSB GRIA4 ARHGEF11 SART1 PTPN9 UBA1 ZBTB21 SCRIB TNR NIPBL	1.95e-05	963	150	15	28671696
Pubmed	Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development.	TFAP2D TFAP2A TFAP2B	2.18e-05	13	150	3	17724084
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	OBSCN ARHGEF12 ARHGEF11 TIAM1	2.19e-05	38	150	4	11756498
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 HNRNPCL1 SENP3 PEX1 LANCL1 ADCY6 PACS1 LIG3 TONSL LPGAT1 SCRIB CRTC2	2.72e-05	650	150	12	38777146
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	OBSCN ARHGEF12 ARHGEF11 TIAM1	3.60e-05	43	150	4	12376548
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	SPAG1 C1orf43 PAK4 SMPD4 ITGB1 ADCY6 PACS1 FAT1 C1orf226 SCRIB EPHA3	3.92e-05	569	150	11	30639242
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SMARCA5 EPPK1 PDLIM7 SERPINH1 ADAR ITGB1 DDX10 SART1 LIG3 UBA1 PLEKHG3 ZBTB21 ACIN1 SCRIB NIPBL	3.94e-05	1024	150	15	24711643
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CUL1 SMARCA5 FARSB LANCL1 SERPINH1 ADAR DDX10 SART1 PHF2 DAP3 LIG3 UBA1 PMPCA STARD9 ALDH18A1 ACIN1 SAMM50 NIPBL	4.53e-05	1425	150	18	30948266
Pubmed	Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.	ARHGEF12 ARHGEF11	5.53e-05	3	150	2	15143072
Pubmed	Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).	ARHGEF12 ARHGEF11	5.53e-05	3	150	2	21454492
Pubmed	Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.	ARHGEF12 ARHGEF11	5.53e-05	3	150	2	12220504
Pubmed	Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.	FAT1 FAT2	5.53e-05	3	150	2	15744052
Pubmed	Transcriptional activation by Myc is under negative control by the transcription factor AP-2.	TFAP2A TFAP2B	5.53e-05	3	150	2	7729426
Pubmed	NAGS, CPS1, and SLC25A13 (Citrin) at the Crossroads of Arginine and Pyrimidines Metabolism in Tumor Cells.	CPS1 NAGS	5.53e-05	3	150	2	37047726
Pubmed	Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.	ARHGEF12 ARHGEF11	5.53e-05	3	150	2	26627240
Pubmed	Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression.	TFAP2A TFAP2B	5.53e-05	3	150	2	7559606
Pubmed	Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility.	ITGB1 TIAM1	5.53e-05	3	150	2	21302295
Pubmed	Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth.	TFAP2A EP300	5.53e-05	3	150	2	25669978
Pubmed	Comprehensive analysis of the expression and prognosis for TFAP2 in human lung carcinoma.	TFAP2A TFAP2B	5.53e-05	3	150	2	32462520
Pubmed	Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin.	FRG2 FRG2B	5.53e-05	3	150	2	11829491
Pubmed	HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway.	ARHGEF12 ARHGEF11	5.53e-05	3	150	2	20844236
Pubmed	The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress.	SENP3 EP300	5.53e-05	3	150	2	22684029
Pubmed	B plexins activate Rho through PDZ-RhoGEF.	ARHGEF12 ARHGEF11	5.53e-05	3	150	2	12372594
Pubmed	A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens.	TFAP2A TFAP2B	5.53e-05	3	150	2	9758708
Pubmed	Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation.	TFAP2A TFAP2B	5.53e-05	3	150	2	11553286
Pubmed	CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation.	EP300 CRTC2	5.53e-05	3	150	2	20859256
Pubmed	FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients.	FRG2 FRG2B	5.53e-05	3	150	2	15520407
Pubmed	Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors.	TFAP2A TFAP2B	5.53e-05	3	150	2	8661133
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	RPF1 CUL1 SMG1 SPAG1 PAK4 WDR81 CEP192 FHOD1 ITPRIP SCRIB HERC1 PIGO	7.15e-05	719	150	12	35337019
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	RPF1 SMG1 CENPL PAK4 EYA2 TIE1 KCNQ1 HERC1 EPHA3	9.30e-05	420	150	9	28065597
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	SPAG1 CEP192 FAT1 TIAM1 SBF2 DECR2	9.98e-05	170	150	6	23314748
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	SMG1 TCAF1 EPPK1 ESS2 PEX1 CEP192 SART1 DAP3 FAT1 EP300 CRTC2	1.10e-04	639	150	11	23443559
Pubmed	Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation.	ITGAX ITGB1	1.10e-04	4	150	2	8020569
Pubmed	Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.	SENP3 EP300	1.10e-04	4	150	2	19622798
Pubmed	The oncogenic role of TFAP2A in bladder urothelial carcinoma via a novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1 axis.	TFAP2A DNMT3A	1.10e-04	4	150	2	36410635
Pubmed	Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development.	TFAP2A TFAP2B	1.10e-04	4	150	2	9765260
Pubmed	Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.	TFAP2A TFAP2B	1.10e-04	4	150	2	12749383
Pubmed	Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.	ENDOG CRTC2	1.10e-04	4	150	2	37794041
Pubmed	Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.	EP300 CRTC2	1.10e-04	4	150	2	17525731
Pubmed	A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning.	TFAP2A TFAP2B	1.10e-04	4	150	2	21829553
Pubmed	Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion.	ITGAX ITGB1	1.10e-04	4	150	2	25278023
Pubmed	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.	SENP3 EP300	1.10e-04	4	150	2	15632193
Pubmed	The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.	TFAP2A TFAP2B	1.10e-04	4	150	2	19115315
Pubmed	PHF2 regulates sarcomeric gene transcription in myogenesis.	PHF2 MYBPC2	1.10e-04	4	150	2	38701072
Pubmed	Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice.	MGLL CRTC2	1.10e-04	4	150	2	27596982
Pubmed	The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription.	EP300 CRTC2	1.10e-04	4	150	2	20101207
Pubmed	The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis.	TFAP2A TFAP2B	1.10e-04	4	150	2	18843039
Pubmed	An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment.	SERPINH1 EP300	1.10e-04	4	150	2	17977830
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	SENP3 UBA1 PTPRK PCK2	1.18e-04	58	150	4	31067491
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	APOO MTERF3 CPS1 GCSH ADAR NAGS DAP3 LIG3 MIGA2 PMPCA ALDH18A1 SAMM50 ENDOG PCK2 ACSS3	1.25e-04	1136	150	15	34800366
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	OBSCN ARHGEF12 ARHGEF11 TIAM1	1.34e-04	60	150	4	12787561
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CUL1 PARP11 EPPK1 PAK4 SMPD4 ALS2 QRICH2 DERA DAP3 LIG3 TIAM1 TONSL ZBTB21 ACIN1 HERC1 CRTC2	1.44e-04	1284	150	16	17353931
Pubmed	Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.	SMARCA5 PHF2 ALDH18A1 ACIN1 ACSS3	1.52e-04	116	150	5	37117180
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	CUL1 SENP3 ALDH18A1 ACIN1	1.73e-04	64	150	4	26511642
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	SERPINH1 SART1 PACS1 LIG3 UBA1 ALDH18A1 ACIN1 NIPBL	1.79e-04	360	150	8	33111431
Pubmed	Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.	EP300 CRTC2	1.83e-04	5	150	2	17476304
Pubmed	SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.	SENP3 EP300	1.83e-04	5	150	2	19680224
Pubmed	Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.	ARHGEF12 ARHGEF11	1.83e-04	5	150	2	12183458
Pubmed	ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.	LDLRAP1 TFAP2A	1.83e-04	5	150	2	12221107
Pubmed	Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.	ARHGEF12 ARHGEF11	1.83e-04	5	150	2	12515866
Pubmed	Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney.	TFAP2A TFAP2B	1.83e-04	5	150	2	35468900
Pubmed	The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism.	TFAP2A TFAP2B	1.83e-04	5	150	2	12228234
Pubmed	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.	TFAP2A TFAP2B	1.83e-04	5	150	2	12072434
Pubmed	Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.	TIAM1 C9orf72	1.83e-04	5	150	2	20801718
Pubmed	AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.	TFAP2D TFAP2A TFAP2B	1.90e-04	26	150	3	19749747
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CUL1 BCL2L14 ESS2 MTERF3 SRCIN1 DAP3 FAT1 ZBTB21 ITPRIP PCK2 DNMT3A	2.11e-04	689	150	11	36543142
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PALD1 SMARCA5 PAK4 FARSB ADAR DDX10 LIG3 UBA1 FHOD1 ZBTB21 ACIN1 SCRIB NIPBL	2.16e-04	934	150	13	33916271
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	SENP3 PAK4 NAIP GRB10 TFAP2A INTS4 CRTC2	2.30e-04	281	150	7	24163370
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TCAF1 MAN1A1 C1orf43 DNAH2 PEX1 FARSB SERPINH1 DDX10 PTPRK LPGAT1 SAMM50 SCRIB PCK2	2.35e-04	942	150	13	31073040
Interaction	NDUFAF4 interactions	BCL2L14 APOO MTERF3 EYA2 PMPCA ACIN1 LRRC61 UNC93B1 C9orf72	8.36e-06	185	146	9	int:NDUFAF4
Interaction	AIFM1 interactions	CUL1 BCL2L14 APOO GRB10 LANCL1 ASB12 SERPINH1 ADAR PMPCA TONSL SAMM50 UNC93B1 C9orf72 ENDOG EP300 PCK2	1.36e-05	629	146	16	int:AIFM1
Interaction	TFAP2A interactions	LDLRAP1 TFAP2D EYA2 TFAP2A TFAP2B EP300 DNMT3A	1.95e-05	114	146	7	int:TFAP2A
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN ARHGEF12 ALS2 ARHGEF11 PLEKHG1 TIAM1 PLEKHG3	3.96e-08	66	91	7	722
GeneFamily	PDZ domain containing	PDLIM7 ARHGEF12 ARHGEF11 CYTIP TIAM1 SCRIB	1.18e-04	152	91	6	1220
GeneFamily	Fibronectin type III domain containing	OBSCN TIE1 PTPRK TNR EPHA3 MYBPC2	1.57e-04	160	91	6	555
Coexpression	GSE7764_IL15_NK_CELL_24H_VS_SPLENOCYTE_DN	MTERF3 ARHGEF12 TG TMEM131 UNC93B1 C9orf72 NIPBL EP300 PCK2	2.31e-06	199	150	9	M5726
Coexpression	MARTINEZ_RESPONSE_TO_TRABECTEDIN	DDX10 TIAM1 PTPRK TMEM131 HERC1	9.88e-06	50	150	5	M5077
Coexpression	OVSYANNIKOVA_PBMC_FLUARIX_AGE_55_64YO_RESPONDERS_VS_NONRESPONDERS_28DY_UP	CUL1 PHF2 SCRIB	1.50e-05	9	150	3	M40906
Coexpression	GSE36009_WT_VS_NLRP10_KO_DC_DN	LDLRAP1 PDLIM7 WDR81 LIG3 PMPCA PLEKHG3 FHOD1 ZBTB21	2.01e-05	199	150	8	M8777
Coexpression	MIKKELSEN_IPS_WITH_HCP_H3K27ME3	ZNF536 TFAP2D HPSE2 CA10 TFAP2B PRDM8	2.88e-05	103	150	6	M1967
Coexpression	MIKKELSEN_IPS_WITH_HCP_H3K27ME3	ZNF536 TFAP2D HPSE2 CA10 TFAP2B PRDM8	3.38e-05	106	150	6	MM1265
Coexpression	COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP	BCL2L14 PDLIM7 ALS2 LPGAT1 C9orf72 TBCEL	3.96e-05	109	150	6	M18762
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A3 ZNF536 TCAF1 PDLIM7 GRB10 HPSE2 PLEKHG1 FAT1	2.44e-07	187	150	8	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GASK1B DIPK2B PLEKHG1 TIAM1 TIE1 ITPRIP INSYN2B	2.75e-07	190	150	8	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	BCL2L14 DNAH2 MGLL MAGEE1 ADCY6 PLEKHG1 BICDL1	1.43e-06	164	150	7	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	2.65e-06	180	150	7	16728b9a1c52097e3a460534be71a476ecc54f0f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	3.41e-06	187	150	7	35c382c0aabd46906113e5db30ea24bb8e658899
ToppCell	Control-Endothelial_cells\|Control / group, cell type (main and fine annotations)	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP TNR	3.54e-06	188	150	7	3953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCell	MS-CD8-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	ZNF487 SPAG1 PAK4 FARSB BAHD1 INTS4 PIGO	3.54e-06	188	150	7	2f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ZNF536 PDE3A HPSE2 ARMC9 FAT1 EPHA3	3.92e-06	191	150	7	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A3 ZNF536 TCAF1 GRB10 HPSE2 PLEKHG1 FAT1	4.06e-06	192	150	7	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B PLEKHG1 TIE1 STARD9	4.06e-06	192	150	7	c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	SPAG1 ITGAX PRDM8 TIE1 STARD9 LPGAT1 UNC93B1	4.20e-06	193	150	7	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ADAMTS18 ITPRIP	4.20e-06	193	150	7	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP INSYN2B	4.65e-06	196	150	7	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	Children_(3_yrs)-Immune-monocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NAIP ITGAX GASK1B CYTIP TIAM1 SBF2 C9orf72	4.65e-06	196	150	7	cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP INSYN2B	4.65e-06	196	150	7	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B PLEKHG1 TIE1 ITPRIP	4.81e-06	197	150	7	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B PLEKHG1 TIE1 STARD9	4.81e-06	197	150	7	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	4.81e-06	197	150	7	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B PLEKHG1 TIE1 ITPRIP	4.81e-06	197	150	7	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B PLEKHG1 TIE1 STARD9	4.81e-06	197	150	7	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	4.97e-06	198	150	7	8689090bce9ab6e8f122426a404037e572c6713b
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ZNF536 PDE3A PDLIM7 MGLL HPSE2 ITGB1 FAT1	4.97e-06	198	150	7	c9c96066c7fa897b583657f0b77ea093920ae9ba
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	COL6A3 TCAF1 PDLIM7 HPSE2 ITGB1 FAT1 EPHA3	5.31e-06	200	150	7	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GRB10 SERPINH1 GASK1B DIPK2B PLEKHG1 TIE1 ADAMTS18	5.31e-06	200	150	7	310c75e13be9194312a8b686804edcf13d44caf5
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	DNAH2 MGLL MAGEE1 PLEKHG1 BICDL1 PRDM8	2.05e-05	165	150	6	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WDR81 CEP192 ARHGEF11 ITGAX ADAR CYTIP	2.27e-05	168	150	6	93b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPL CEP192 ITGAX PLEKHG3 ZBTB21 PIGO	2.27e-05	168	150	6	4c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WDR81 CEP192 ARHGEF11 ITGAX ADAR CYTIP	2.27e-05	168	150	6	e393553208617a023f1646169c892a87c95db3f5
ToppCell	Control-Endothelial_cells-Systemic_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	GRB10 TFAP2B GASK1B DIPK2B PLEKHG1 TIE1	2.59e-05	172	150	6	c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAN1A1 OBSCN ITGB1 DIPK2B TIE1 KCNQ1	2.59e-05	172	150	6	9a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TFAP2A FAT2 C1orf226 TESMIN NXPH4 MSLN	2.95e-05	176	150	6	8d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ZNF536 SRCIN1 TFAP2A TFAP2B GASK1B PHACTR3	3.05e-05	177	150	6	59726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEP192 ARHGEF11 PRDM8 SBF2 TNR PIGO	3.56e-05	182	150	6	d486b0213bd3cf20965cb4e38e95981c4aaff259
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B TIE1 ITPRIP	3.67e-05	183	150	6	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B TIE1 ITPRIP	3.67e-05	183	150	6	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAN1A1 CYTIP TG ALDH18A1 UNC93B1 PCK2	3.79e-05	184	150	6	82d2daa39e3c31a74c08a5d77366740b87beb2fb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A MGLL CPS1 CA10 TFAP2B PHACTR3	3.79e-05	184	150	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF536 SRCIN1 EYA2 FAT1 PHACTR3 EPHA3	3.90e-05	185	150	6	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	PBMC-Control-cDC_10\|Control / Compartment, Disease Groups and Clusters	BCL2L14 GRB10 MGLL PLEKHG1 BICDL1 FAT2	3.90e-05	185	150	6	4b5a7450fed912f340da16065c1e65d626dbe8d1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF536 SRCIN1 EYA2 FAT1 PHACTR3 EPHA3	3.90e-05	185	150	6	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	COL6A3 PDE3A PDLIM7 OBSCN PLEKHG3 STARD9	4.14e-05	187	150	6	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 TCAF1 HPSE2 ADCY6 DERA EPHA3	4.27e-05	188	150	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 TCAF1 HPSE2 ADCY6 DERA EPHA3	4.27e-05	188	150	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 TCAF1 HPSE2 ADCY6 DERA EPHA3	4.27e-05	188	150	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF536 SRCIN1 TFAP2A TFAP2B GASK1B PHACTR3	4.27e-05	188	150	6	ccd2541892112a7a303f766adf9a7afeb754498c
ToppCell	Healthy_donor-NK_CD56bright\|Healthy_donor / disease group, cell group and cell class (v2)	SPAG1 BICDL1 PRDM8 TIE1 STARD9 TNR	4.40e-05	189	150	6	9eac380a3bb4b685effb52d816e1960972660646
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ZNF536 PDE3A HPSE2 FAT1 EPHA3	4.40e-05	189	150	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALD1 ARHGEF12 DIPK2B PLEKHG1 TIE1 STARD9	4.53e-05	190	150	6	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-immature_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ARMC9 MAGEE1 SERPINH1 ITGB1 GASK1B DIPK2B	4.53e-05	190	150	6	b8693567e26edb830482a60746bf3632a2bf058c
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 PDE3A HPSE2 EYA2 PHACTR3 EPHA3	4.66e-05	191	150	6	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PALD1 ARHGEF12 DIPK2B PLEKHG1 TIE1 STARD9	4.66e-05	191	150	6	f229abf69a1217194f74b0502486907e07dba989
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ZNF536 PDE3A HPSE2 FAT1 EPHA3	4.66e-05	191	150	6	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	facs-Thymus-Epithelium-24m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL SERPINH1 GASK1B DIPK2B TIE1 KCNQ1	4.80e-05	192	150	6	39afea574725ce0c67afdd79facdb34f819a828d
ToppCell	facs-Thymus-Epithelium-24m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL SERPINH1 GASK1B DIPK2B TIE1 KCNQ1	4.80e-05	192	150	6	597db951b1fbc37db22134c3d27d3ec4ceaa85f7
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF536 PDE3A PDLIM7 HPSE2 FAT1 EPHA3	4.80e-05	192	150	6	992d08092edbc68c47b945deb8708379738c239a
ToppCell	facs-Thymus-Epithelium-24m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGLL SERPINH1 GASK1B DIPK2B TIE1 KCNQ1	4.80e-05	192	150	6	bc275a9eccb1c7a46fd58b15ca5acdd9f7495842
ToppCell	human_hepatoblastoma-Endothelial_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	PALD1 GRB10 MGLL DIPK2B TIE1 ITPRIP	4.80e-05	192	150	6	e09f609fed033a25baacaf4a07bbbae1076da366
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP EPHA3	4.80e-05	192	150	6	28eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 PDE3A GASK1B PTPRK EPHA3 MYBPC2	4.94e-05	193	150	6	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	COL6A3 TFAP2A TFAP2B GASK1B PLEKHG3 PHACTR3	4.94e-05	193	150	6	e1de67ddada87229f5db0ec193a6da8745a86a64
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Mesenchymal-choroid_plexus/mesenchymal-like_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	COL6A3 TFAP2A TFAP2B GASK1B PLEKHG3 PHACTR3	4.94e-05	193	150	6	b6f5a85210e60798205eaf5884cdb540f549d08a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GASK1B DIPK2B PLEKHG1 TIE1 ITPRIP INSYN2B	4.94e-05	193	150	6	287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9	5.08e-05	194	150	6	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.08e-05	194	150	6	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF12 GRB10 DIPK2B PLEKHG1 TIE1 PTPRK	5.08e-05	194	150	6	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP INSYN2B	5.08e-05	194	150	6	b490fffc94f005dff9a34ce34d80ca776e3a1387
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9	5.08e-05	194	150	6	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 DIPK2B PLEKHG1 TIE1 ADAMTS18 ITPRIP	5.08e-05	194	150	6	fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9	5.08e-05	194	150	6	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.23e-05	195	150	6	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A ARHGEF12 ITGB1 PLEKHG1 TIE1 PTPRK	5.23e-05	195	150	6	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GASK1B DIPK2B PLEKHG1 TIE1 ITPRIP EPHA3	5.23e-05	195	150	6	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	GRB10 GASK1B DIPK2B PLEKHG1 TIE1 ITPRIP	5.38e-05	196	150	6	ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 GASK1B DIPK2B PLEKHG1 TIE1	5.38e-05	196	150	6	023312af38f816a44b407e0daa32590d953caf99
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.38e-05	196	150	6	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.38e-05	196	150	6	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9	5.38e-05	196	150	6	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.38e-05	196	150	6	d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	5.38e-05	196	150	6	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	5.38e-05	196	150	6	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.38e-05	196	150	6	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.38e-05	196	150	6	e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 DIPK2B PLEKHG1 TIE1 STARD9 ITPRIP	5.38e-05	196	150	6	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 FPR1 NAIP ITGAX CYTIP INSYN2B	5.53e-05	197	150	6	1eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.69e-05	198	150	6	07701c73137947ed4a27e225975329235bbb8734
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 PDLIM7 GRB10 MGLL HPSE2 ITGB1	5.69e-05	198	150	6	63f7d25201613bd3404c28fb936954190bca91d3
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 PDLIM7 GRB10 MGLL HPSE2 ITGB1	5.69e-05	198	150	6	a73534b6ca202c277a70a52281d5b97a3e6cb8ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.69e-05	198	150	6	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.69e-05	198	150	6	451003a21162eeae90739fdb502bb50b362d80c8
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF536 PDLIM7 GRB10 MGLL HPSE2 ITGB1	5.69e-05	198	150	6	d1e1bdd36c84e1bac21ba137f018defe98456a8c
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 PDE3A ARMC9 GASK1B PTPRK EPHA3	5.69e-05	198	150	6	12cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell	distal-1-Endothelial-Bronchial_Vessel_1\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GRB10 SERPINH1 GASK1B DIPK2B PLEKHG1 ADAMTS18	5.69e-05	198	150	6	5cd81fe1a21c0e1a7f0d5a62ddf8e422b05aedc7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.69e-05	198	150	6	440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 ITPRIP	5.69e-05	198	150	6	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 GRB10 DIPK2B PLEKHG1 TIE1 STARD9	5.69e-05	198	150	6	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	medial-2-Endothelial-Capillary_Aerocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PALD1 PAK4 DIPK2B PLEKHG1 TIE1 ITPRIP	5.85e-05	199	150	6	c5048b31649a0b7eddcd481b0458ed96508f5561
ToppCell	distal-Endothelial-Capillary_Aerocyte-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PALD1 PAK4 DIPK2B PLEKHG1 TIE1 ITPRIP	5.85e-05	199	150	6	9021f4be004efd51bb3658e5bbff53589356b3df
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRB10 GASK1B DIPK2B PLEKHG1 TIE1 ADAMTS18	5.85e-05	199	150	6	0d63da0afa93741c37609d879941de202d9ac86c
ToppCell	medial-Endothelial-Capillary_Aerocyte\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PALD1 PAK4 DIPK2B PLEKHG1 TIE1 ITPRIP	5.85e-05	199	150	6	84e30c39c2f050aa64af167999824c1cba32ba05
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GRB10 SERPINH1 GASK1B DIPK2B PLEKHG1 TIE1	5.85e-05	199	150	6	6a7ecc3a68b9cfc49e50abaeb16e2eee3795377e
Disease	sleep disorder (implicated_via_orthology)	TFAP2D TFAP2A TFAP2B	1.83e-05	11	144	3	DOID:535 (implicated_via_orthology)
Disease	citrulline measurement	LANCL1 CPS1 ALDH18A1	1.22e-04	20	144	3	EFO_0009777
Disease	gamma-glutamylcitrulline measurement	LANCL1 CPS1	1.41e-04	4	144	2	EFO_0800690
Disease	Clinodactyly	TFAP2A TFAP2B	1.41e-04	4	144	2	C4551485
Disease	Clinodactyly of fingers	TFAP2A TFAP2B	1.41e-04	4	144	2	C0265610
Disease	calcium measurement	BCL2L14 PDE3A ERCC5 DNAH2 WDR81 HPSE2 EYA2 CPS1 TMEM131 AGBL2 DNMT3A	2.71e-04	628	144	11	EFO_0004838
Disease	electrocardiography	ABRA RPGRIP1 HCN4 FPR1 OBSCN ARMC9 ADAR LIG3 ADAMTS18 KCNQ1	2.88e-04	530	144	10	EFO_0004327
Disease	Disorder of the urea cycle metabolism	CPS1 NAGS	3.50e-04	6	144	2	cv:C0154246
Disease	Squamous cell carcinoma	ERCC5 ITGB1 UBA1 TIAM1 EP300	3.65e-04	124	144	5	C0007137
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	ATP13A5 ALS2 C9orf72	4.20e-04	30	144	3	DOID:332 (implicated_via_orthology)
Disease	Hyperammonemia	CPS1 NAGS	4.89e-04	7	144	2	C0220994
Disease	Craniofacial Abnormalities	TFAP2A TFAP2B NIPBL EP300 DNMT3A	1.03e-03	156	144	5	C0376634
Disease	long QT syndrome (implicated_via_orthology)	ARHGAP36 KCNQ1	1.04e-03	10	144	2	DOID:2843 (implicated_via_orthology)
Disease	overweight body mass index status	ABRA TFAP2D	1.26e-03	11	144	2	EFO_0005935
Disease	pars orbitalis volume measurement	PARP11 ACSS3	1.26e-03	11	144	2	EFO_0010320
Disease	ADHD symptom measurement	ARHGEF12 PCK2	1.51e-03	12	144	2	EFO_0007860
Disease	forced expiratory volume, response to bronchodilator	EPPK1 HCN4 GRB10 GRIA4 MGLL ITGAX ADAMTS18 SERPINA10	1.59e-03	445	144	8	EFO_0004314, GO_0097366
Disease	glycerol-3-phosphate measurement	OR5AU1 CFAP43	2.38e-03	15	144	2	EFO_0010488
Disease	central nervous system disease (implicated_via_orthology)	SMARCA5 GRIA4	2.71e-03	16	144	2	DOID:331 (implicated_via_orthology)
Disease	Astrocytosis	ITGB1 TNR	3.07e-03	17	144	2	C3887640
Disease	Amyotrophic lateral sclerosis	ALS2 C9orf72	3.07e-03	17	144	2	cv:C0002736
Disease	Gliosis	ITGB1 TNR	3.07e-03	17	144	2	C0017639
Disease	body weight	MAN1A1 TFAP2D ARHGEF12 GRB10 ATP13A5 CEP192 EYA2 CPS1 TFAP2B ADCY6 PTPN9 KCNQ1 SCRIB NIPBL	3.55e-03	1261	144	14	EFO_0004338
Disease	hypertension	COL6A3 PDE3A ARHGEF12 PRDM8 TIAM1 SBF2	4.06e-03	307	144	6	EFO_0000537
Disease	serum homoarginine measurement	CPS1 KCNQ1	4.24e-03	20	144	2	EFO_0005421

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPFTLGQLKELLGRT	ACIN1	1021	Q9UKV3
SLLRSIHFPIRGNKT	NAIP	911	Q13075
KRLPSTRLGTFLENR	EP300	1291	Q09472
RVSLRLKNITPSDIG	BTNL3	96	Q6UXE8
VGPFKLRSRKQRTLS	AKAP2	706	Q9Y2D5
FPGLTRRTKLKGNIL	CFAP43	96	Q8NDM7
SLLPKILVNGTVFAR	ATP13A5	811	Q4VNC0
RKPIRVLSLFDGIAT	DNMT3A	631	Q9Y6K1
GLLSQVSPRLLRKAA	ALS2	486	Q96Q42
GSLFPKALQRLSRSI	ADCY6	721	O43306
TFSPVLKLNAVLIRS	ARHGEF11	1021	O15085
LPAGRRKAANVTLLT	TFAP2A	276	P05549
ALFSPKLLRTRSLSQ	BCL2L14	41	Q9BZR8
RNPLIASSFSLVKLV	C22orf31	66	O95567
GAASQLKDILRPLRT	DIPK2B	401	Q9H7Y0
PAGSLRTALNELKRL	BICDL1	411	Q6ZP65
SGLIRTRKNEFLISP	ADAMTS18	166	Q8TE60
ALLLTKAPQVLRFSR	ANKRD6	256	Q9Y2G4
GILSPSELRKIFSNL	ARHGEF12	821	Q9NZN5
PAGRRKAANVTLLTS	TFAP2B	296	Q92481
LPAGRRKAANVTLLT	TFAP2D	276	Q7Z6R9
LLRKAVSAQIPESGR	NXPH4	16	O95158
FLELVSRKLSLVPGA	QRICH2	31	Q9H0J4
ISFPIGQRLLGSKRK	ARHGAP36	211	Q6ZRI8
ALRLPGRKLVSSAVS	INTS4	586	Q96HW7
FTLVGKPLLAFRNLR	ITGAX	736	P20702
LRLRSGEPQTFTLKF	ITGB1	121	P05556
IASFLLSKQSRLTGP	ITPRIP	411	Q8IWB1
PLRSEILSGKFTILN	PTPN9	86	P43378
GQPSLSGFRRVLQKL	PALD1	136	Q9ULE6
SAGRALIRSPSLAKQ	LDLRAP1	6	Q5SW96
TLSLKAVDQGLPRRL	FAT1	3196	Q14517
IALAVVPSKRQRLSG	HNRNPCL1	136	O60812
SGRQLALRLFSKVRP	KIAA0100	1981	Q14667
RRLDQSIGKPSLFIS	KCNQ1	561	P51787
TLPRSGATKIILNAL	LPGAT1	211	Q92604
RRLSIFGNPKRLLSV	MAGEE1	616	Q9HCI5
GRLTPEFSQRLTNKI	LANCL1	26	O43813
KLTVPFLLLQGSADR	MGLL	226	Q99685
QRSVGPASLSLLTFK	APOO	6	Q9BUR5
QKLRGNSTLTVRPAF	SBF2	1246	Q86WG5
ITPQLLKSRTGEFSL	LRRC61	16	Q9BV99
KGIALLLQARATPRS	ASB12	256	Q8WXK4
LGALQKFSLRRPLQT	ARMC9	436	Q7Z3E5
DSIQRKFLPSFLRGI	HERC1	3306	Q15751
LSFPTLKASLTRGLQ	C9orf131	1046	Q5VYM1
GSSLRTPVNLAVLKL	GRIA4	761	P48058
GLRAIDTTQLFSLPK	PCK2	586	Q16822
SGVISLKRPFINLTA	FAT2	616	Q9NYQ8
SVLNPAFLGLSRKLT	FAT2	1926	Q9NYQ8
VLQPLRSSRKLSSAL	PDE3A	51	Q14432
NKPALLRSLFTVGAL	NIPBL	2136	Q6KC79
SLPRVLTAARKLAGA	DECR2	61	Q9NUI1
SQLRLTPGLRKVLFA	MIGA2	36	Q7L4E1
PGTSSAVLFLSKLQR	MICAL1	626	Q8TDZ2
LRTGPALLSVRKFTE	GCSH	41	P23434
FSRITKANVDLLPRG	MSLN	141	Q13421
RPTKIIFLNNTGGLR	NAGS	286	Q8N159
LRRKPVLSFQGSHLR	LIG3	51	P49916
LSSKRLVTLARGLSP	HPSE2	96	Q8WWQ2
PRFLISILTGDKSIS	OR6C76	76	A6NM76
RLSLGLSRAQPVQSK	PDLIM7	76	Q9NR12
LKRLQSLIPSALGSA	HCN4	826	Q9Y3Q4
GFLNRALRTDLVSPK	SMPD4	486	Q9NXE4
KRILRSNEIVLPASG	PACS1	151	Q6VY07
GRLAAPLLKRLSLST	ALDH18A1	416	P54886
LRDLQVAPGTRLAKF	OBSCN	5266	Q5VST9
LTTGKQRLIKRAPFS	PARP11	96	Q9NR21
ALTLARKLQSRGFPS	GLYATL3	231	Q5SZD4
GLVTRFLQISRKAPD	FAM189B	586	P81408
SRALGVQTPSIRKSL	FRG2B	161	Q96QU4
SRALGVQTPSIRKSL	FRG2	161	Q64ET8
LGLNRTLPSVSRKAE	GASK1B	286	Q6UWH4
RRVTENLASLTPKGL	ESS2	376	Q96DF8
FSRPGIRLLSVKAQT	CPS1	31	P31327
LPIAVRFAKTLLANS	CBLIF	151	P27352
LLDLRNTSTPFKGVR	C1orf43	136	Q9BWL3
TNSFQPSLLGRKILA	ADAR	856	P55265
FIGATPLQKRLESVR	CENPL	21	Q8N0S6
LIERNGFKLSLSPIS	C1orf226	226	A1L170
KGQLFRLPSALNRTS	CRTC2	156	Q53ET0
LGEVLTQLSSRFKPR	CUL1	731	Q13616
LKLSDAGITPLFLTR	COL6A3	2531	P12111
KVLLTRLENVAGPRS	BAHD1	71	Q8TBE0
LFSILSTKRPLQAPR	AGBL2	166	Q5U5Z8
LIRNPGSLKIITSAA	EPHA3	881	P29320
TLPRGRKQLALTRSS	CYTIP	51	O60759
SGPAALRLTEKFVLL	MAN1A1	31	P33908
ELLTRLTSKPFGILS	CEP192	2236	Q8TEP8
QQRKALLSPFSTPVR	GRB10	411	Q13322
SLGLAVAPRVRFLQK	DDX10	501	Q13206
SGPELRRSLFSLKQI	FHOD1	131	Q9Y613
FLTPLRINTGGRKVS	CA10	81	Q9NS85
LKPELFRIGASTLLS	DERA	281	Q9Y315
VKPLFLSRAALTGLA	DNAH2	76	Q9P225
SRNSSILPRRGALLK	SAMM50	266	Q9Y512
KALRGFLPASLRSVN	PEX1	816	O43933
LDQVFQLKPGLSLRS	C9orf72	381	Q96LT7
QLKPGLSLRSTFLAQ	C9orf72	386	Q96LT7
RDLVPLKAFLLAGTT	LRRC43	476	Q8N309
LSFIRRVKLSNPPSA	PTPRK	1061	Q15262
VSPSLKGFLDRLLVR	PAK4	541	O96013
LTKRFTRPARTLLHG	MTERF3	26	Q96E29
GRFLPASTKLNLITQ	TESMIN	261	Q9Y4I5
TLSDRQGITKSAPLR	EYA2	31	O00167
PVRRNSKLATLGRIF	PHACTR3	61	Q96KR7
IVSALSQTGSLFKPR	DAP3	306	P51398
IQTALSSKDGRLPRT	PMPCA	506	Q10713
LATPIGRLKVSLQAA	RPGRIP1	1256	Q96KN7
VERRLKLGSLTQFPN	PHF2	351	O75151
LTRASKLFRGPLVIN	TCAF1	581	Q9Y4C2
PKGLVRNSISRFNSL	PLEKHG3	746	A1L390
LLFVPNILARAGSLK	ENDOG	276	Q14249
IFRRLSLGRIKPSQS	OR5AU1	16	Q8NGC0
QGLIKSSRPLRVLSF	FPR1	231	P21462
QTRLKRVLSGATLPD	PNMA3	291	Q9UL41
RSFSQLSPLVLGQKL	PRDM8	506	Q9NQV8
AQFTVLSKLRTPLGR	SMG1	921	Q96Q15
LSKLRTPLGRAQDTF	SMG1	926	Q96Q15
GSISPRTLSAIKRAL	ERCC5	381	P28715
PLQATFRGLRKQVSA	EPPK1	1516	P58107
QSGSLLFIGRLVRPK	SERPINH1	396	P50454
TTASRKNPLGLIVAL	SI	806	P14410
VFISKVLPRGLAARS	SCRIB	1036	Q14160
SSFIKRQPLVIARLA	STARD9	4681	Q9P2P6
PRFLGAIITRNKTIS	OR6C3	76	Q9NZP0
RTTLLPGLLKTIAAN	FARSB	451	Q9NSD9
GPAKSALRKIRTATL	ABRA	11	Q8N0Z2
RSGKIPRSALSAIVN	ACSS3	646	Q9H6R3
FSTPSRKGLVLQLIQ	SENP3	351	Q9H4L4
QELGPRFTLKLRSLQ	RPF1	306	Q9H9Y2
RSGPLVKSLLRRSLS	ZBTB21	331	Q9ULJ3
FNKTVLRTLPRSGNL	UNC93B1	271	Q9H1C4
LKDFLSQPSLGLLVR	TIAM1	911	Q13009
SASQTKLRSPGVLFL	SRCIN1	171	Q9C0H9
FSSGTLTLTRRPKLQ	TIE1	811	P35590
ELLSTLQKRPQGLSF	TONSL	1296	Q96HA7
LEPGNVKALLRRATT	SPAG1	271	Q07617
FGTLRTQDLPKVLNL	TMEM131	331	Q92545
TVRKLFSSLGLLLPS	SLC17A2	346	O00624
APKNLRVGSRTATSL	TNR	596	Q92752
LVSSLPGRNKQLRRF	TECPR2	106	O15040
KLRLQAQSLSTVGPR	SART1	371	O43290
KFVERTLRLAGTQPL	UBA1	671	P22314
LPSLFKGLRETLSRN	SERPINA10	141	Q9UK55
SSKASLFIRPDILRG	ZNF536	826	O15090
VSLPFLGKLSSLQRI	PIGO	96	Q8TEQ8
SQALLTPVKSRAGRA	PLEKHG1	896	Q9ULL1
EFKTTNRLLLTGTPL	SMARCA5	326	O60264
RGLARLALQFTTNPK	TG	451	P01266
TQPLLKRASAGLQRV	TMEM234	21	Q8WY98
LVIARLPSVSKLNGS	TBCEL	276	Q5QJ74
NFRGTLTSLALLPTK	WDR81	1911	Q562E7
FSLDTNPILSRKIRG	ZNF487	151	B1APH4
RAKIPGLLNQTSRSL	THPO	226	P40225
GFRNIAIQTSPSLRK	INSYN2B	91	A6NMK8
FTVKNLPTGARILFR	MYBPC2	796	Q14324