Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RGPD2 RGPD1	2.06e-05	20	54	3	GO:0061665
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD4 RGPD2 RGPD1	1.25e-04	36	54	3	GO:0019789
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RGPD4 RGPD2 RGPD1	3.35e-04	50	54	3	GO:0003755
GeneOntologyMolecularFunction	large ribosomal subunit rRNA binding	RPLP0 RPLP0P6	3.89e-04	11	54	2	GO:0070180
GeneOntologyMolecularFunction	cis-trans isomerase activity	RGPD4 RGPD2 RGPD1	3.98e-04	53	54	3	GO:0016859
GeneOntologyMolecularFunction	cell adhesion molecule binding	NPTN CKAP5 TMOD3 ADAM17 ITGA9 LCP1 EPCAM	1.10e-03	599	54	7	GO:0050839
GeneOntologyMolecularFunction	cell adhesion mediator activity	TMOD3 ITGA9 EPCAM	1.14e-03	76	54	3	GO:0098631
GeneOntologyMolecularFunction	cadherin binding involved in cell-cell adhesion	TMOD3 EPCAM	1.19e-03	19	54	2	GO:0098641
GeneOntologyMolecularFunction	isomerase activity	RGPD4 RGPD2 FBH1 RGPD1	1.80e-03	192	54	4	GO:0016853
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RGPD2 RGPD1	1.33e-06	9	53	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RGPD2 RGPD1	1.90e-06	10	53	3	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD4 RGPD2 RGPD1	4.50e-06	13	53	3	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD4 RGPD2 RGPD1	5.72e-06	14	53	3	GO:1903299
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 RGPD2 RGPD1	1.77e-05	20	53	3	GO:0006607
GeneOntologyBiologicalProcess	regulation of gluconeogenesis	RGPD4 RGPD2 HIF1A RGPD1	3.32e-05	71	53	4	GO:0006111
GeneOntologyBiologicalProcess	protein peptidyl-prolyl isomerization	RGPD4 RGPD2 RGPD1	1.27e-04	38	53	3	GO:0000413
GeneOntologyBiologicalProcess	regulation of transforming growth factor beta2 production	HIF1A WNT11	1.80e-04	8	53	2	GO:0032909
GeneOntologyBiologicalProcess	transforming growth factor beta2 production	HIF1A WNT11	1.80e-04	8	53	2	GO:0032906
GeneOntologyBiologicalProcess	gluconeogenesis	RGPD4 RGPD2 HIF1A RGPD1	1.90e-04	111	53	4	GO:0006094
GeneOntologyBiologicalProcess	response to antibiotic	HIF1A SCN3A ETS1	1.97e-04	44	53	3	GO:0046677
GeneOntologyBiologicalProcess	hexose biosynthetic process	RGPD4 RGPD2 HIF1A RGPD1	2.17e-04	115	53	4	GO:0019319
GeneOntologyBiologicalProcess	monosaccharide biosynthetic process	RGPD4 RGPD2 HIF1A RGPD1	2.64e-04	121	53	4	GO:0046364
GeneOntologyBiologicalProcess	regulation of carbohydrate metabolic process	RGPD4 RGPD2 HIF1A RGPD1 TRIM63	3.13e-04	231	53	5	GO:0006109
GeneOntologyBiologicalProcess	associative learning	NPTN HIF1A CKAP5 ELAVL4	3.47e-04	130	53	4	GO:0008306
GeneOntologyBiologicalProcess	peptidyl-proline modification	RGPD4 RGPD2 RGPD1	3.62e-04	54	53	3	GO:0018208
GeneOntologyBiologicalProcess	positive regulation of phosphate metabolic process	RAB38 RGPD4 RGPD2 NPTN FBH1 RGPD1 ADAM17 LIMCH1 MAP3K4	3.65e-04	879	53	9	GO:0045937
GeneOntologyBiologicalProcess	positive regulation of phosphorus metabolic process	RAB38 RGPD4 RGPD2 NPTN FBH1 RGPD1 ADAM17 LIMCH1 MAP3K4	3.65e-04	879	53	9	GO:0010562
GeneOntologyBiologicalProcess	regulation of carbohydrate biosynthetic process	RGPD4 RGPD2 HIF1A RGPD1	3.68e-04	132	53	4	GO:0043255
GeneOntologyBiologicalProcess	regulation of glucose metabolic process	RGPD4 RGPD2 HIF1A RGPD1	3.90e-04	134	53	4	GO:0010906
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD2 RGPD1	8.54e-07	8	53	3	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD2 RGPD1	1.82e-06	10	53	3	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD2 RGPD1	5.49e-06	14	53	3	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RGPD2 RGPD1	1.22e-05	18	53	3	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RGPD2 RGPD1	1.70e-05	20	53	3	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RGPD2 RGPD1	1.98e-05	21	53	3	GO:0106068
GeneOntologyCellularComponent	inclusion body	RGPD4 RGPD2 RGPD1	1.55e-03	90	53	3	GO:0016234
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD4 RGPD2 RGPD1	1.81e-05	16	46	3	MP:0003701
MousePheno	abnormal morula morphology	RGPD4 RGPD2 RGPD1	8.22e-05	26	46	3	MP:0012058
MousePheno	decreased tumor latency	RGPD4 RGPD2 RGPD1	1.27e-04	30	46	3	MP:0010308
MousePheno	failure of blastocyst formation	RGPD4 RGPD2 RGPD1	1.41e-04	31	46	3	MP:0012129
MousePheno	abnormal tumor latency	RGPD4 RGPD2 RGPD1	1.86e-04	34	46	3	MP:0010307
Domain	GCC2_Rab_bind	RGPD4 RGPD2 RGPD1	7.07e-07	7	52	3	IPR032023
Domain	Rab_bind	RGPD4 RGPD2 RGPD1	7.07e-07	7	52	3	PF16704
Domain	-	RGPD4 RGPD2 RGPD1	2.41e-06	10	52	3	1.10.220.60
Domain	Grip	RGPD4 RGPD2 RGPD1	3.31e-06	11	52	3	SM00755
Domain	GRIP	RGPD4 RGPD2 RGPD1	3.31e-06	11	52	3	PF01465
Domain	Ran_BP1	RGPD4 RGPD2 RGPD1	4.40e-06	12	52	3	PF00638
Domain	GRIP_dom	RGPD4 RGPD2 RGPD1	4.40e-06	12	52	3	IPR000237
Domain	GRIP	RGPD4 RGPD2 RGPD1	4.40e-06	12	52	3	PS50913
Domain	RANBD1	RGPD4 RGPD2 RGPD1	4.40e-06	12	52	3	PS50196
Domain	RanBD	RGPD4 RGPD2 RGPD1	5.71e-06	13	52	3	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD2 RGPD1	5.71e-06	13	52	3	IPR000156
Domain	TPR-contain_dom	RGPD4 RGPD2 IFT140 RGPD1	8.02e-04	150	52	4	IPR013026
Domain	TPR_REGION	RGPD4 RGPD2 IFT140 RGPD1	1.14e-03	165	52	4	PS50293
Domain	TPR	RGPD4 RGPD2 IFT140 RGPD1	1.14e-03	165	52	4	PS50005
Domain	TPR-like_helical_dom	RGPD4 RGPD2 IFT140 RGPD1	4.00e-03	233	52	4	IPR011990
Domain	TPR	RGPD4 RGPD2 RGPD1	5.56e-03	129	52	3	SM00028
Domain	TPR_repeat	RGPD4 RGPD2 RGPD1	6.05e-03	133	52	3	IPR019734
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD4 RGPD2 RGPD1	1.43e-05	18	38	3	MM1549
Pathway	REACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES	RGPD4 RGPD2 RGPD1 CKAP5	1.46e-04	100	38	4	MM14561
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RGPD4 RGPD2 RGPD1	1.67e-04	40	38	3	MM14945
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RGPD4 RGPD2 RGPD1	1.79e-04	41	38	3	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RGPD4 RGPD2 RGPD1	1.93e-04	42	38	3	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RGPD4 RGPD2 RGPD1	2.07e-04	43	38	3	MM14609
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	RGPD4 RGPD2 RGPD1 CKAP5	2.68e-04	117	38	4	MM15387
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RGPD4 RGPD2 RGPD1	2.70e-04	47	38	3	MM14939
Pathway	REACTOME_GENE_SILENCING_BY_RNA	RGPD4 RGPD2 RGPD1	3.06e-04	49	38	3	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RGPD4 RGPD2 RGPD1	3.25e-04	50	38	3	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RGPD4 RGPD2 RGPD1	3.44e-04	51	38	3	MM15151
Pathway	REACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION	RGPD4 RGPD2 RGPD1 CKAP5	3.88e-04	129	38	4	MM14894
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	RGPD4 RGPD2 RGPD1	4.30e-04	55	38	3	MM14917
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RGPD4 RGPD2 RGPD1	5.03e-04	58	38	3	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	RGPD4 RGPD2 RGPD1	5.03e-04	58	38	3	MM14736
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_FORMINS	RGPD4 RGPD2 RGPD1 CKAP5	5.44e-04	141	38	4	MM15266
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	RGPD4 RGPD2 RGPD1	7.03e-04	65	38	3	MM15147
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	RGPD4 RGPD2 RGPD1	9.87e-04	73	38	3	MM14948
Pathway	REACTOME_GLUCOSE_METABOLISM	RGPD4 RGPD2 RGPD1	1.38e-03	82	38	3	MM15394
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	RGPD4 RGPD2 RGPD1	1.48e-03	84	38	3	MM14929
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	RGPD4 RGPD2 RGPD1	1.59e-03	86	38	3	MM15413
Pathway	REACTOME_SEPARATION_OF_SISTER_CHROMATIDS	RGPD4 RGPD2 RGPD1 CKAP5	1.75e-03	193	38	4	MM14890
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	RGPD4 RGPD2 RGPD1	1.92e-03	92	38	3	MM14951
Pathway	REACTOME_MITOTIC_PROMETAPHASE	RGPD4 RGPD2 RGPD1 CKAP5	2.06e-03	202	38	4	MM15362
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	RGPD4 RGPD2 HIF1A UBXN7 RGPD1 ETS1	2.14e-03	505	38	6	MM15548
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	8603673
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	15710750
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD2 RGPD1	1.30e-07	7	55	3	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD2 RGPD1	2.08e-07	8	55	3	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD2 RGPD1	2.08e-07	8	55	3	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD2 RGPD1	2.08e-07	8	55	3	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD2 RGPD1	2.08e-07	8	55	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD2 RGPD1	2.08e-07	8	55	3	21310149
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	18394993
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	28100513
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD2 RGPD1	3.12e-07	9	55	3	17887960
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD2 RGPD1	4.46e-07	10	55	3	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD2 RGPD1	4.46e-07	10	55	3	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD2 RGPD1	4.46e-07	10	55	3	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD2 RGPD1	4.46e-07	10	55	3	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD2 RGPD1	6.12e-07	11	55	3	35771867
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD2 RGPD1	6.12e-07	11	55	3	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RGPD2 RGPD1	6.12e-07	11	55	3	34110283
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	RGPD4 RGPD2 RPLP0 TAX1BP1 RGPD1 TMOD3 ADAM17 LIMCH1 EPCAM	7.49e-07	647	55	9	26618866
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD2 RGPD1	1.06e-06	13	55	3	31427429
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RGPD2 RGPD1	1.68e-06	15	55	3	14697343
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 RGPD2 NPTN TAX1BP1 RGPD1 CKAP5 ELAVL4 LIMCH1 ARMCX4 TMEM132B	2.39e-06	963	55	10	28671696
Pubmed	Inhibition of HIF1α-Dependent Upregulation of Phospho-l-Plastin Resensitizes Multiple Myeloma Cells to Frontline Therapy.	HIF1A LCP1	2.46e-06	2	55	2	29882856
Pubmed	Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.	HIF1A ADAM17	2.46e-06	2	55	2	24871629
Pubmed	Hypoxia modulates stem cell properties and induces EMT through N-glycosylation of EpCAM in breast cancer cells.	HIF1A EPCAM	2.46e-06	2	55	2	31584203
Pubmed	Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy.	HIF1A EPCAM	2.46e-06	2	55	2	24566861
Pubmed	Hypoxia in abdominal aortic aneurysm supports a role for HIF-1α and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells.	HIF1A ETS1	2.46e-06	2	55	2	20938207
Pubmed	High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells.	HIF1A ADAM17	2.46e-06	2	55	2	26175156
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD4 RGPD2 RGPD1	5.64e-06	22	55	3	27717094
Pubmed	UBXN7 cofactor of CRL3KEAP1 and CRL2VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins.	HIF1A UBXN7	7.36e-06	3	55	2	33444648
Pubmed	Regulation of hypoxia-inducible genes by ETS1 transcription factor.	HIF1A ETS1	7.36e-06	3	55	2	18381358
Pubmed	Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells.	HIF1A ADAM17	7.36e-06	3	55	2	17884817
Pubmed	Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰.	HIF1A ADAM17	7.36e-06	3	55	2	31640947
Pubmed	The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.	HIF1A ETS1	1.47e-05	4	55	2	18720385
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	RGPD4 RGPD2 RGPD1 CKAP5 TMOD3	2.33e-05	215	55	5	35973513
Pubmed	Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein.	HIF1A UBXN7	2.45e-05	5	55	2	32005965
Pubmed	Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.	TAX1BP1 ELAVL4	2.45e-05	5	55	2	21282516
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD4 RGPD2 RGPD1	3.04e-05	38	55	3	12791264
Pubmed	Quantitative proteomics identifies a Dab2/integrin module regulating cell migration.	NPTN ADGRG2 CPM	5.07e-05	45	55	3	19581412
Pubmed	UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.	HIF1A UBXN7	5.13e-05	7	55	2	22537386
Pubmed	Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.	RGPD4 RGPD2 RPLP0 RGPD1	6.35e-05	135	55	4	31077711
Pubmed	Endothelial Cyp26b1 restrains murine heart valve growth during development.	ART4 ETS1 TMOD3 LIMCH1	1.32e-04	163	55	4	35364055
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	VPS13D RBM46 LIMCH1 LCP1 MAP3K4 ZNF292	1.32e-04	497	55	6	36774506
Pubmed	Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.	WNT11 EPCAM	2.54e-04	15	55	2	28077488
Pubmed	Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.	RPLP0 TMOD3 LCP1	2.72e-04	79	55	3	14729942
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZSCAN4 ETS1 ELAVL4 ITGA9 CFI	2.73e-04	363	55	5	14691545
Pubmed	Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.	MPEG1 LCP1	2.90e-04	16	55	2	33082323
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RGPD4 RGPD2 RGPD1 CKAP5 LCP1	2.98e-04	370	55	5	22922362
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	NPTN ERGIC3 RPLP0 CKAP5 C18orf32	3.17e-04	375	55	5	32788342
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	RGPD4 RGPD2 RGPD1	3.49e-04	86	55	3	37253089
Pubmed	Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.	MPEG1 CPM	4.13e-04	19	55	2	22987638
Pubmed	Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis.	ELAVL4 LIMCH1	4.58e-04	20	55	2	19268448
Pubmed	Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development.	HIF1A EPCAM	4.58e-04	20	55	2	39040069
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD4 RGPD2 ZSCAN4 RGPD1 CKAP5	5.20e-04	418	55	5	34709266
Pubmed	Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.	RGPD4 RGPD2 RGPD1	5.27e-04	99	55	3	27746211
Pubmed	An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.	HIF1A ETS1	7.79e-04	26	55	2	33238123
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	RPLP0P6 TAX1BP1 TMOD3 LIMCH1	8.17e-04	264	55	4	32814769
Pubmed	TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.	RPLP0 FHL5	9.70e-04	29	55	2	21383078
Pubmed	Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.	RPLP0 ETS1	1.04e-03	30	55	2	21575865
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	IFT140 VPS13D CKAP5	1.16e-03	130	55	3	12421765
Pubmed	Secondary Placental Defects in Cxadr Mutant Mice.	HIF1A WNT11	1.18e-03	32	55	2	31338035
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	RPLP0 CKAP5 TMOD3	1.35e-03	137	55	3	37039823
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	VPS13D GZF1 EPCAM MAP3K4 C18orf32	1.57e-03	536	55	5	15840001
Pubmed	Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation.	ELAVL4 CPM	1.58e-03	37	55	2	20510229
Coexpression	TABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING	RGPD4 RGPD2 RGPD1 ADAM17	1.87e-06	43	54	4	MM3857
Coexpression	MENON_FETAL_KIDNEY_2_NEPHRON_PROGENITOR_CELLS	RPLP0 RPLP0P6 LIMCH1 EPCAM	2.05e-06	44	54	4	M39252
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP	RGPD4 RGPD2 RGPD1	4.32e-05	33	54	3	MM477
Coexpression	GSE32533_MIR17_KO_VS_MIR17_OVEREXPRESS_ACT_CD4_TCELL_DN	FBH1 MPEG1 LCP1 CFI EPCAM	5.74e-05	200	54	5	M8470
Coexpression	GSE40274_LEF1_VS_FOXP3_AND_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	CYP4V2 HIF1A DNAI4 ADAM17 CPM	5.74e-05	200	54	5	M9158
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_100	RBM44 RBM46 TEX15 EPCAM	2.36e-05	67	53	4	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_100
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#4_top-relative-expression-ranked_100	RBM44 RBM46 TEX15	5.12e-05	29	53	3	gudmap_developingGonad_e16.5_ovary_100_k4
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_200	RBM44 RBM46 TEX15	5.12e-05	29	53	3	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k4_200
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_200	RBM44 RBM46 TEX15	6.28e-05	31	53	3	gudmap_developingGonad_e14.5_ ovary_200_k3
ToppCell	Endothelial-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ART4 SCN3A AKNAD1 OVOS2 ITGA9	2.36e-06	173	55	5	a81992965137195d20fc498f750975303961a828
ToppCell	droplet-Lung-LUNG-1m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPM TEX15 ITGA9 EPCAM SLC44A3	3.03e-06	182	55	5	c1e0be27064e14043b78ae501b02d4e9542267a3
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPM TEX15 ITGA9 EPCAM SLC44A3	3.03e-06	182	55	5	3c9b4869d357884ae4bcd22a9872faf83a5cfc6d
ToppCell	distal-Endothelial-Lymphatic-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ART4 ZSCAN4 AKNAD1 ITGA9 CFI	4.35e-06	196	55	5	b0f23dc802a2c2a56a08d398a464ea78b58ade4c
ToppCell	18-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	RPLP0 CPM CFI EPCAM SLC44A3	4.57e-06	198	55	5	fdd3b428483dbca0fc5b1412446a812e8ad616a9
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Cdkn1c_(Cdkn1c)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	AKNAD1 CFI IL17F	4.10e-05	54	55	3	69f66fe78fd59c44b6ca6b565df0ea8e035121e1
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Cdkn1c_(Cdkn1c)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	AKNAD1 CFI IL17F	4.10e-05	54	55	3	75dd172b298d3fb81f3e0c82f593772cb3487b62
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Cdkn1c_(Cdkn1c)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	AKNAD1 CFI IL17F	4.10e-05	54	55	3	67cc62761906a29e9f7beb03b74f600e516c47f1
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HIF1A ADAM17 ITGA9 LCP1	4.45e-05	159	55	4	6c0ef40f64d2e35eaae3d0002e3c1f22d1239736
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HIF1A ADAM17 ITGA9 LCP1	4.45e-05	159	55	4	745a59c33b04620c5329bdd50e74a8e611f2dc55
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RGPD2 ADGRG2 TAX1BP1 ETS1	4.90e-05	163	55	4	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAB38 RBM44 AKNAD1 TRIM63	5.39e-05	167	55	4	69caf4a53805f8c104d7dd8f88665fc992e23720
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ART4 ZSCAN4 ELAVL4 ITGA9	5.77e-05	170	55	4	6035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ART4 ZSCAN4 ELAVL4 ITGA9	5.77e-05	170	55	4	c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ART4 ZSCAN4 ELAVL4 ITGA9	5.77e-05	170	55	4	dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCell	BL-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WNT11 AKNAD1 LIMCH1 EPCAM	5.77e-05	170	55	4	b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13D ETS1 DNAI4 CPM	6.04e-05	172	55	4	ce444463f69bbb05c933615a0f1f43ddde3eee1c
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13D ETS1 DNAI4 CPM	6.04e-05	172	55	4	2c993a93ac91dcf6061eec001f51f8cccb6ee264
ToppCell	E18.5-samps-Epithelial-Alveolar_epithelial-AT2\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CYP4V2 CPM ITGA9 EPCAM	6.18e-05	173	55	4	f6e36ea98a9c669ff393d141455aaecef083f738
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VPS13D ETS1 DNAI4 CPM	6.32e-05	174	55	4	33386750842c47ad7e7286d0f26a556da1a2de02
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-regulatory_T_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	VPS13D ETS1 DNAI4 CPM	6.32e-05	174	55	4	9344d4e76d7d9429aea87d3c0b98246200d16014
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIF1A GZF1 MPEG1 LCP1	7.52e-05	182	55	4	c3eafdc11858566aa7692b2f5dbe72ac01fb769a
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAX1BP1 ETS1 TMOD3 ZUP1	7.52e-05	182	55	4	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MPEG1 ELAVL4 RBM46 LCP1	7.68e-05	183	55	4	9840706f972387241bf1d4ba8af25efc3214a91b
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	VPS13D SCN3A CPM FHL5	7.68e-05	183	55	4	273db6a3b00a93ca852498471187b642b5368185
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MPEG1 ELAVL4 RBM46 LCP1	7.68e-05	183	55	4	409cb52cf4c967e52bf75a6680bcbe87f638c75d
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte-type_2_alveolar_epithelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEX15 ITGA9 EPCAM SLC44A3	7.85e-05	184	55	4	24cbe9f2461ea920954e44bf3b2c2a6a5d4debfb
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial-type_II_pneumocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEX15 ITGA9 EPCAM SLC44A3	7.85e-05	184	55	4	98079fd048a63b51bbdf3833b6f15bf0ae99ea90
ToppCell	droplet-Lung-1m-Epithelial-alveolar_epithelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TEX15 ITGA9 EPCAM SLC44A3	7.85e-05	184	55	4	86c1551c4f7c7d0c35c14852b01b1e602fa5092a
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LIMCH1 ITGA9 EPCAM SLC44A3	8.01e-05	185	55	4	0d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	SCN3A ETS1 CPM FHL5	8.01e-05	185	55	4	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	facs-Lung-EPCAM-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN3A CPM EPCAM SLC44A3	8.18e-05	186	55	4	7c4eb769574f9f32753cea1cc38c711dabba88b9
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CPM CFI EPCAM SLC44A3	8.35e-05	187	55	4	c2940aec30b3c2c113f6a65126dc6f1969cf301e
ToppCell	facs-Skin-nan-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ART4 ADGRG2 ETS1 LIMCH1	8.70e-05	189	55	4	6c71e81373cb7822de23c193a6350b6df9f567bc
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	8.88e-05	190	55	4	8ff8c586237cf15f930416710bcff45205fe6f70
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG2 WNT11 TEX15 ITGA9	8.88e-05	190	55	4	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	SCN3A ETS1 CPM FHL5	8.88e-05	190	55	4	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG2 WNT11 TEX15 ITGA9	8.88e-05	190	55	4	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	IPF-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	ART4 SCN3A ITGA9 CFI	8.88e-05	190	55	4	ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nnat_(Neuron.Slc17a6.Nnat)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RBM44 AKNAD1 IL17F	8.93e-05	70	55	3	df81f7c1d901eb34b82f564ee15c10a0f4dd153f
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nnat_(Neuron.Slc17a6.Nnat)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RBM44 AKNAD1 IL17F	8.93e-05	70	55	3	2895c9fa3b2c1fadbcfef7814ee4ce8cc5e76cfd
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GZF1 CPM ITGA9 EPCAM	9.06e-05	191	55	4	08b1d3b3be78bf7fd9e9039027e35275f2be88d0
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GZF1 CPM ITGA9 EPCAM	9.06e-05	191	55	4	f896fb490c4a17adac5e00ed9b6e6145eab1e564
ToppCell	PND14-Epithelial-Epithelial_Alveolar\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.06e-05	191	55	4	5f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.06e-05	191	55	4	2f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.06e-05	191	55	4	4ab3056f9af2a6caed39f32288562f480811cd7b
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.25e-05	192	55	4	7ccdb977320d09f21e70e7718ead73eeb56d0c48
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ELAVL4 CPM EPCAM SLC44A3	9.25e-05	192	55	4	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYP4V2 EPCAM SLC44A3 C18orf32	9.25e-05	192	55	4	1a3d95a9801cc4569b67fa652b2af46c4dedbaef
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.25e-05	192	55	4	f206c015f091234e2c86dfa66926e97b2ea99690
ToppCell	11.5-Airway-Epithelial-Bud_tip_adjacent\|Airway / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	9.25e-05	192	55	4	fbb34a959b9bd9cb72a5195a07f4653a957e4ca8
ToppCell	PND28-Epithelial-Epithelial_Alveolar\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.25e-05	192	55	4	69963e8dc6d6368243e61da133484eb23225625a
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CPM TEX15 ITGA9 EPCAM	9.25e-05	192	55	4	bfc68af68fdb99ddfe4add49671e4b4c26e6f962
ToppCell	ILEUM-inflamed-(1)_Th17_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ETS1 LCP1 IL17F MAP3K4	9.43e-05	193	55	4	0663c57e1b8b8dd70d617d029fc7bdbbda8c1208
ToppCell	11.5-Airway-Epithelial-Bud_tip_progenitor\|Airway / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	9.43e-05	193	55	4	f0a07bb221a497a9f7cc706045d5205269be4515
ToppCell	droplet-Bladder-nan-24m-Epithelial-basal_bladder_epithelial_cell_(Krt5+Krt14+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIF1A RPLP0 ETS1 EPCAM	9.43e-05	193	55	4	9d7bc71c4ae871aad057d3beb6e06c929ae17203
ToppCell	facs-Liver-Non-hepatocytes-3m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPTN ETS1 ARMCX4 ITGA9	9.43e-05	193	55	4	8084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCell	18-Airway-Epithelial-Bud_tip_adjacent\|Airway / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	9.62e-05	194	55	4	b45f1e80074a19245bc5dc4b3a583419a1904404
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CPM CFI EPCAM SLC44A3	9.82e-05	195	55	4	ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCell	11.5-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.00e-04	196	55	4	42eae265e2f2082983d8c2607c7f6a53a526d124
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ART4 SCN3A ETS1 ITGA9	1.00e-04	196	55	4	09a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ART4 SCN3A ETS1 ITGA9	1.00e-04	196	55	4	e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIF1A GZF1 MPEG1 LCP1	1.00e-04	196	55	4	01cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCell	11.5-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.00e-04	196	55	4	2648d64b0e7b59ae78182d55f32699ceea37ff8d
ToppCell	11.5-Distal-Epithelial-Bud_tip_adjacent\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.00e-04	196	55	4	a6a242868df0d2ff30825624a8d7c0367527594d
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LIMCH1 CPM CFI EPCAM	1.00e-04	196	55	4	65e161fd672e37a5d10f28011bb422c4d7042d6a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)\|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group	HIF1A RPLP0 LCP1 CFI	1.02e-04	197	55	4	72a29a796b253a35c8772117a800d2a72fd89a3f
ToppCell	15-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.02e-04	197	55	4	532635810f17199fa6c14b986f663884d5d05ab5
ToppCell	15-Distal-Epithelial\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.02e-04	197	55	4	9fbd1abf050b364155a67962a9731118304f72fb
ToppCell	11.5-Distal-Epithelial\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.02e-04	197	55	4	ae9505ae7e6c5e8c280f9bfb1ba79ab5bd8895e3
ToppCell	11.5-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.02e-04	197	55	4	e671af1b69566d97afe97f1a959a07b6f4c05620
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TAX1BP1 ETS1 LCP1 C18orf32	1.04e-04	198	55	4	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	distal-1-Endothelial-Lymphatic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ART4 AKNAD1 ITGA9 CFI	1.04e-04	198	55	4	b6fea363463c8dd7e6780c085ece4900266a6286
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRIM63 CPM ITGA9 LCP1	1.04e-04	198	55	4	cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRIM63 CPM ITGA9 LCP1	1.04e-04	198	55	4	d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCell	Caecum-(6)_Macrophage-(61)_LYVE1_Macrophage\|Caecum / shred on region, Cell_type, and subtype	ART4 MPEG1 LIMCH1 FHL5	1.04e-04	198	55	4	e684c3934c163aef4d284b69435832d2c9614f2a
ToppCell	Caecum-Macrophage-LYVE1_Macrophage\|Caecum / Region, Cell class and subclass	ART4 MPEG1 LIMCH1 FHL5	1.04e-04	198	55	4	a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Lymphatic\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	ART4 SCN3A ETS1 ITGA9	1.06e-04	199	55	4	88f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ART4 SCN3A ETS1 ITGA9	1.06e-04	199	55	4	64b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCell	Biopsy_Other_PF-Endothelial-Lymphatic_Endothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ART4 SCN3A ITGA9 CFI	1.06e-04	199	55	4	aa80c77fe4f6a141c780c7d8ecfff5d5a1c3b845
ToppCell	ASK428-Epithelial\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	LIMCH1 CPM CFI EPCAM	1.06e-04	199	55	4	ba2aaaeb4d9b448a6b9660b152fcac1a0e3fcfe7
ToppCell	18-Distal-Epithelial\|Distal / Age, Tissue, Lineage and Cell class	CPM CFI EPCAM SLC44A3	1.06e-04	199	55	4	592451359c7469496cd794df55ccc5f0d55bd661
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ART4 SCN3A ETS1 ITGA9	1.06e-04	199	55	4	2b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ART4 SCN3A ITGA9 CFI	1.08e-04	200	55	4	c59f262b2b0a7e7dcb2940d1e466f98db6c56625
ToppCell	Severe-Myeloid-Macrophages-FCN1_high\|Severe / Condition, Lineage, Cell class and cell subclass	HIF1A MPEG1 ADAM17 LCP1	1.08e-04	200	55	4	449623d6786e30d493f68156b3f1ee8caf9265a6
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ART4 SCN3A ITGA9 CFI	1.08e-04	200	55	4	e50ef394e3284a8323bfd60575b262b2be422aea
ToppCell	metastatic_Brain-Epithelial_cells-Malignant_cells\|Epithelial_cells / Location, Cell class and cell subclass	ERGIC3 TAX1BP1 LIMCH1 EPCAM	1.08e-04	200	55	4	c5c4fef077b56f19d7cec26f5b698dd688bc30a7
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRIM63 ELAVL4 LIMCH1	4.18e-04	118	55	3	f0f40a0165156e3fc1584480b473b0e84e10d2cc
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TRIM63 ELAVL4 LIMCH1	4.28e-04	119	55	3	a6b359e7aafcc197f53eb5e19c3a905bc09497bb
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBH1 ARMCX4 ITGA9	5.18e-04	127	55	3	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	droplet-Heart-HEART-1m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IFT140 VPS13D TRIM63	5.18e-04	127	55	3	983489a69d3b1f1fe21110a862ac1dba53e9d31c
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7\|TCGA-Lung / Sample_Type by Project: Shred V9	ART4 TRIM63 ITGA9	5.54e-04	130	55	3	0219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh\|GI_small-bowel / Manually curated celltypes from each tissue	RGPD1 DNAI4 ARMCX4	6.05e-04	134	55	3	bf94ce5edde8912a27010e229c313d8102d6de62
ToppCell	10x3'2.3-week_17-19-Myeloid_macrophage-stroma-erythroid_macrophage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RAB38 RPLP0 EPCAM	7.02e-04	141	55	3	1e01cfbfbe7d5a6fdaf74c78f286f62ea7898e2d
ToppCell	Control-Myeloid-Dendritic_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MPEG1 ELAVL4 LCP1	7.31e-04	143	55	3	bb8d4c335682d1a6798bed0de8bb0603054a4944
ToppCell	LPS_only-Myeloid-Dendritic_cells-mDC\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAB38 MPEG1 ELAVL4	7.92e-04	147	55	3	26bd9d89e2e7b841cc18030bb7cebb642b987183
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MPEG1 LCP1 TMEM132B	8.39e-04	150	55	3	57f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETS1 TRIM63 IL17F	8.39e-04	150	55	3	207fc230d7721149c7afc7970dd56817f52801d8
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ELAVL4 EPCAM SLC44A3	8.72e-04	152	55	3	854c841c1fc6300b7e9be9c98cbf9b0ce2678690
ToppCell	COVID-19_Mild-PLT_5\|World / Disease Group and Platelet Clusters	ETS1 LCP1 ZUP1	8.72e-04	152	55	3	90ba4e8a735ec8921038fa072129535f0e3fd9ae
Disease	Down syndrome (biomarker_via_orthology)	RPLP0 RPLP0P6	2.81e-06	2	50	2	DOID:14250 (biomarker_via_orthology)
Disease	factor XI measurement	CYP4V2 ZNF160	7.83e-05	8	50	2	EFO_0004694
Disease	alcohol and nicotine codependence	RGPD2 RGPD1	2.17e-04	13	50	2	EFO_0004776
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	CKAP5 ZNF160	5.79e-04	21	50	2	EFO_0004286, EFO_0004792
Disease	atrophic macular degeneration	TEX15 CFI	8.23e-04	25	50	2	EFO_1001492
Disease	cholesterol to total lipids in small LDL percentage	ANKRD31 LCP1	9.61e-04	27	50	2	EFO_0022241
Disease	cholesterol to total lipids in medium LDL percentage	ANKRD31 LCP1	9.61e-04	27	50	2	EFO_0022238
Disease	triglycerides to total lipids in large VLDL percentage	ANKRD31 LCP1	2.00e-03	39	50	2	EFO_0022332
Disease	psoriasis (is_marker_for)	HIF1A CFI	2.54e-03	44	50	2	DOID:8893 (is_marker_for)
Disease	cholesterol to total lipids in large VLDL percentage	ANKRD31 LCP1	2.66e-03	45	50	2	EFO_0022236
Disease	cholesteryl esters to total lipids in small VLDL percentage	ANKRD31 LCP1	3.15e-03	49	50	2	EFO_0022256
Disease	free cholesterol in LDL measurement	ANKRD31 LCP1	3.27e-03	50	50	2	EFO_0022266

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTGCKNMLFQQNKDG	ACSBG2	446	Q5FVE4
ESGLFKAKQCNGTSM	EPCAM	101	P16422
NGKYISQMKACDGIN	CFI	231	P05156
TEMEQVSKNEGCQAG	GZF1	271	Q9H116
MFNEKEDSCNGKGRM	ADGRG2	986	Q8IZP9
DFNTNKCKGFGFVTM	ELAVL4	336	P26378
AKIDAGGNTNAMCKV	ARMCX4	336	Q5H9R4
DTNKGKVNFKGADMN	C18orf32	46	Q8TCD1
MKSQINEGKDFCGNK	RBM44	331	Q6ZP01
MNEENIDGTNGCSKV	RBM46	1	Q8TBY0
ANKCDQGKDVLMNNG	RAB38	126	P57729
QANTDDGSCEGKMTN	MPEG1	361	Q2M385
DMNSKQNGSDCTLDG	ANKRD31	1516	Q8N7Z5
KGCKSSEQNGMEQKT	HIF1A	756	Q16665
KGVDFQKFCMNGAAL	ETS1	91	P14921
GGNMKKLENCNYAVE	LCP1	451	P13796
GFSQKMQEQKNEGCQ	ERGIC3	186	Q9Y282
NGQMKNKDDECFGDD	EDC3	181	Q96F86
KQSSACPNEGMEQQK	OVOS2	866	Q6IE36
KCFIVGADNVGSKQM	RPLP0	26	P05388
GCINAQGKEDISMNS	IL17F	106	Q96PD4
MVVGQEKGNCSFQKN	ITGA9	846	Q13797
GDVKCGNNAKEAMTA	CKAP5	691	Q14008
TQNKEIFCQKCGSGM	FHL5	266	Q5TD97
AGKQPCTNDMAKSNS	FBH1	66	Q8NFZ0
ECKNKMNFPNGVTNG	CPM	241	P14384
DSGTEMQSNKCQDCG	AKNAD1	656	Q5T1N1
CETAMGKNIGAQSND	CYP4V2	201	Q6ZWL3
MQTFNGAPKNKDVQC	DNAI4	291	Q5VTH9
DSFGNMCGKKNSPVE	SLC44A3	66	Q8N4M1
DEKFGFEKGENMNCV	IFT140	316	Q96RY7
GSGTMNKIDLGNCQD	LIMCH1	851	Q9UPQ0
QCGKMANKANTSGDF	RGPD1	991	P0DJD0
DKKTISFQGCMGQLF	OR4A5	86	Q8NH83
DFGCSVKLKNNAQTM	MAP3K4	1481	Q9Y6R4
KCFIVGADNVGSKQM	RPLP0P6	26	Q8NHW5
SQCGKMANKANTSGD	RGPD4	1006	Q7Z3J3
KMEGQNSQSPQCFKT	TAX1BP1	601	Q86VP1
SNNCDSIFVNGKEMK	TMEM132B	476	Q14DG7
AGEKLFSSQCGKMAN	RGPD2	991	P0DJD1
EGNKIDSCMSNNTGI	SCN3A	1041	Q9NY46
SGDHENNKMFSNCSK	ADAM17	441	P78536
KGCQLGKTEQGFENM	TRIM63	291	Q969Q1
QGEGKMYECNQVEKS	ZNF160	196	Q9HCG1
SENKNEGQDATMYCK	NPTN	246	Q9Y639
TSQDKNEQGGMLCSQ	ZNF292	1216	O60281
MVCGYKEQGKDSCQG	PRSS42P	251	Q7Z5A4
QFMIGGHCNDKASVK	ZSCAN4	91	Q8NAM6
GTSDNKKDNTLQCGM	ZUP1	71	Q96AP4
DFCMKNEKVGSHGTQ	WNT11	281	O96014
KGSFETAKECGQMQN	UBXN7	151	O94888
NKVTMAGQCKDQGNF	TEX15	141	Q9BXT5
NTKFCNIMGSSNGVD	TMOD3	146	Q9NYL9
VKGAGSSEINCNMND	VPS13D	3566	Q5THJ4
YQGCSKQVMEKLTQG	ART4	66	Q93070