Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycerol channel activity	AQP7B AQP7P3 AQP7	8.07e-07	7	58	3	GO:0015254
GeneOntologyMolecularFunction	urea transmembrane transporter activity	AQP7B AQP7P3 AQP7	1.93e-06	9	58	3	GO:0015204
GeneOntologyMolecularFunction	glycerol transmembrane transporter activity	AQP7B AQP7P3 AQP7	1.93e-06	9	58	3	GO:0015168
GeneOntologyMolecularFunction	polyol transmembrane transporter activity	AQP7B AQP7P3 AQP7	6.52e-06	13	58	3	GO:0015166
GeneOntologyMolecularFunction	water channel activity	AQP7B AQP7P3 AQP7	1.54e-05	17	58	3	GO:0015250
GeneOntologyMolecularFunction	water transmembrane transporter activity	AQP7B AQP7P3 AQP7	2.56e-05	20	58	3	GO:0005372
GeneOntologyMolecularFunction	urea channel activity	AQP7P3 AQP7	8.25e-05	5	58	2	GO:0015265
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	AQP7B AQP7P3 AQP7	2.46e-04	42	58	3	GO:0015144
GeneOntologyMolecularFunction	amide transmembrane transporter activity	AQP7B AQP7P3 AQP7	2.46e-04	42	58	3	GO:0042887
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	AQP7B AQP7P3 AQP7	1.11e-03	70	58	3	GO:1901618
GeneOntologyMolecularFunction	kinase binding	PITPNM1 CDC37 PRAM1 ADCY4 ANK2 TIAM1 BARD1 PICK1 SFN	1.80e-03	969	58	9	GO:0019900
GeneOntologyBiologicalProcess	glycerol transmembrane transport	AQP7B AQP7P3 AQP7	1.75e-06	9	58	3	GO:0015793
GeneOntologyBiologicalProcess	polyol transmembrane transport	AQP7B AQP7P3 AQP7	4.56e-06	12	58	3	GO:0015791
GeneOntologyBiologicalProcess	urea transmembrane transport	AQP7B AQP7P3 AQP7	4.56e-06	12	58	3	GO:0071918
GeneOntologyBiologicalProcess	urea transport	AQP7B AQP7P3 AQP7	7.51e-06	14	58	3	GO:0015840
GeneOntologyBiologicalProcess	protein K6-linked ubiquitination	UBE2D2 UBE2D3 BARD1	1.40e-05	17	58	3	GO:0085020
GeneOntologyBiologicalProcess	keratinocyte proliferation	EREG OVOL1 SFN OVOL2	4.49e-05	70	58	4	GO:0043616
GeneOntologyBiologicalProcess	negative regulation of stem cell proliferation	OVOL1 SFN OVOL2	9.88e-05	32	58	3	GO:2000647
GeneOntologyBiologicalProcess	water transport	AQP7B AQP7P3 AQP7	9.88e-05	32	58	3	GO:0006833
GeneOntologyBiologicalProcess	one-carbon compound transport	AQP7B AQP7P3 AQP7	1.08e-04	33	58	3	GO:0019755
GeneOntologyBiologicalProcess	protein K11-linked ubiquitination	UBE2D2 UBE2D3 CDC27	1.53e-04	37	58	3	GO:0070979
GeneOntologyBiologicalProcess	fluid transport	AQP7B AQP7P3 AQP7	2.24e-04	42	58	3	GO:0042044
GeneOntologyBiologicalProcess	renal water absorption	AQP7P3 AQP7	3.45e-04	10	58	2	GO:0070295
MousePheno	decreased urine glycerol level	AQP7P3 AQP7	1.31e-05	2	51	2	MP:0030781
MousePheno	abnormal urine glycerol level	AQP7P3 AQP7	3.91e-05	3	51	2	MP:0030782
Domain	TF_Ovo-like	OVOL1 OVOL2	8.83e-06	2	56	2	IPR027755
Domain	C2H2_Znf_fam	OVOL1 OVOL2	2.34e-03	24	56	2	IPR027775
Domain	UBQ-conjugating_AS	UBE2D2 UBE2D3	2.53e-03	25	56	2	IPR023313
Domain	K_chnl_volt-dep_Kv	KCNA2 KCNB2	2.95e-03	27	56	2	IPR003968
Domain	VG_K_chnl	KCNA2 KCNB2	4.39e-03	33	56	2	IPR028325
Domain	Ion_trans_dom	KCNA2 TRPM7 KCNB2	4.85e-03	114	56	3	IPR005821
Domain	Ion_trans	KCNA2 TRPM7 KCNB2	4.85e-03	114	56	3	PF00520
Domain	UQ_con	UBE2D2 UBE2D3	6.09e-03	39	56	2	PF00179
Domain	-	MATR3 UPF3B RBM47 LARP7	6.13e-03	244	56	4	3.30.70.330
Domain	UBIQUITIN_CONJUGAT_1	UBE2D2 UBE2D3	6.40e-03	40	56	2	PS00183
Domain	UBQ-conjugat_E2	UBE2D2 UBE2D3	6.72e-03	41	56	2	IPR000608
Domain	UBIQUITIN_CONJUGAT_2	UBE2D2 UBE2D3	6.72e-03	41	56	2	PS50127
Domain	Nucleotide-bd_a/b_plait	MATR3 UPF3B RBM47 LARP7	7.45e-03	258	56	4	IPR012677
Pubmed	L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.	UBE2D3 BARD1 LARP7	1.85e-08	4	59	3	32726637
Pubmed	E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes.	UBE2D2 UBE2D3 BARD1	2.08e-06	15	59	3	21965653
Pubmed	Cryoprotectants up-regulate expression of mouse oocyte AQP7, which facilitates water diffusion during cryopreservation.	AQP7P3 AQP7	2.83e-06	2	59	2	23290745
Pubmed	Over-expression of AQP7 contributes to improve insulin resistance in adipocytes.	AQP7P3 AQP7	2.83e-06	2	59	2	22877989
Pubmed	Aquaporin-7 Regulates the Response to Cellular Stress in Breast Cancer.	AQP7P3 AQP7	2.83e-06	2	59	2	32631905
Pubmed	Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.	OVOL1 OVOL2	2.83e-06	2	59	2	26873447
Pubmed	Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel.	AQP7P3 AQP7	2.83e-06	2	59	2	11457862
Pubmed	Cardioprotective effect of St. Thomas' Hospital No. 2 solution against age-related changes in aquaporin-7-deficient mice.	AQP7P3 AQP7	2.83e-06	2	59	2	37691043
Pubmed	Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis.	OVOL1 OVOL2	2.83e-06	2	59	2	17049212
Pubmed	Aquaporin 7 is upregulated through the PI3K-Akt pathway and modulates decidualisation of endometrial stromal cells.	AQP7P3 AQP7	2.83e-06	2	59	2	37879294
Pubmed	Aquaporin7 expression during perinatal development of mouse brain.	AQP7P3 AQP7	2.83e-06	2	59	2	17052846
Pubmed	Prolonged Starvation Causes Up-Regulation of AQP1 in Adipose Tissue Capillaries of AQP7 Knock-Out Mice.	AQP7P3 AQP7	2.83e-06	2	59	2	27455244
Pubmed	Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells.	AQP7P3 AQP7	2.83e-06	2	59	2	21968069
Pubmed	Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice.	AQP7P3 AQP7	2.83e-06	2	59	2	17123523
Pubmed	Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.	AQP7P3 AQP7	2.83e-06	2	59	2	11972053
Pubmed	Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue.	AQP7P3 AQP7	2.83e-06	2	59	2	15591341
Pubmed	Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.	AQP7P3 AQP7	2.83e-06	2	59	2	37432580
Pubmed	Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.	AQP7P3 AQP7	2.83e-06	2	59	2	17576812
Pubmed	Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation.	AQP7P3 AQP7	2.83e-06	2	59	2	15746100
Pubmed	Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation.	AQP7P3 AQP7	2.83e-06	2	59	2	26634435
Pubmed	Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization.	AQP7P3 AQP7	2.83e-06	2	59	2	21130427
Pubmed	The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator.	AQP7P3 AQP7	2.83e-06	2	59	2	19297367
Pubmed	AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism.	AQP7P3 AQP7	2.83e-06	2	59	2	17077387
Pubmed	Dynamic subcellular localization of aquaporin-7 in white adipocytes.	AQP7P3 AQP7	2.83e-06	2	59	2	25643985
Pubmed	Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping.	AQP7P3 AQP7	2.83e-06	2	59	2	9714739
Pubmed	A new role for aquaporin 7 in insulin secretion.	AQP7P3 AQP7	2.83e-06	2	59	2	22415076
Pubmed	Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions.	OVOL1 OVOL2	8.48e-06	3	59	2	22737237
Pubmed	Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9.	AQP7P3 AQP7	8.48e-06	3	59	2	12351427
Pubmed	Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes.	AQP7P3 AQP7	8.48e-06	3	59	2	20573496
Pubmed	The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice.	OVOL1 OVOL2	8.48e-06	3	59	2	9808631
Pubmed	Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein.	UBE2D2 BARD1	8.48e-06	3	59	2	12431996
Pubmed	BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.	UBE2D3 BARD1	8.48e-06	3	59	2	15905410
Pubmed	Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.	AQP7P3 AQP7	8.48e-06	3	59	2	15998844
Pubmed	Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase.	AQP7P3 AQP7	8.48e-06	3	59	2	16009937
Pubmed	Adipocyte lipolysis drives acute stress-induced insulin resistance.	AQP7P3 AQP7	8.48e-06	3	59	2	33097799
Pubmed	Association of Aquaporin 7 and 9 with Obesity and Fatty Liver in db/db Mice.	AQP7P3 AQP7	8.48e-06	3	59	2	38064372
Pubmed	Identification of a family of closely related human ubiquitin conjugating enzymes.	UBE2D2 UBE2D3	8.48e-06	3	59	2	8530467
Pubmed	Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma.	OVOL1 OVOL2	8.48e-06	3	59	2	28339425
Pubmed	Channel-dependent permeation of water and glycerol in mouse morulae.	AQP7P3 AQP7	8.48e-06	3	59	2	16339044
Pubmed	Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.	UBE2D2 UBE2D3	8.48e-06	3	59	2	30095198
Pubmed	Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.	UBE2D2 UBE2D3	8.48e-06	3	59	2	11912157
Pubmed	Expression of aquaporin-7 and aquaporin-9 in tanycyte cells and choroid plexus during mouse estrus cycle.	AQP7P3 AQP7	8.48e-06	3	59	2	27746040
Pubmed	Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa.	AQP7P3 AQP7	8.48e-06	3	59	2	18829704
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	DCAF1 UBE2D3 CDC27	1.64e-05	29	59	3	24239288
Pubmed	Physical and functional interactions between ZIP kinase and UbcH5.	UBE2D2 UBE2D3	1.69e-05	4	59	2	18515077
Pubmed	The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.	UBE2D2 UBE2D3	1.69e-05	4	59	2	31241013
Pubmed	HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase.	DCAF1 UBE2D2	1.69e-05	4	59	2	29079575
Pubmed	Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation.	AQP7P3 AQP7	1.69e-05	4	59	2	11952783
Pubmed	Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.	UBE2D2 UBE2D3	1.69e-05	4	59	2	9535861
Pubmed	Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.	UBE2D2 UBE2D3	1.69e-05	4	59	2	20696396
Pubmed	The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate.	UBE2D3 BARD1	1.69e-05	4	59	2	28564596
Pubmed	LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.	AQP7P3 AQP7	1.69e-05	4	59	2	34807469
Pubmed	The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles.	AQP7P3 AQP7	1.69e-05	4	59	2	19005169
Pubmed	Molecular mechanism of the increased tissue uptake of trivalent inorganic arsenic in mice with type 1 diabetes mellitus.	AQP7P3 AQP7	1.69e-05	4	59	2	29890131
Pubmed	BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.	UBE2D3 BARD1	1.69e-05	4	59	2	15886201
Pubmed	The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.	DCAF1 UBE2D2	1.69e-05	4	59	2	21226479
Pubmed	Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor alpha deficiency.	AQP7P3 AQP7	1.69e-05	4	59	2	17245390
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	ZBTB33 UBE2D2 UBE2D3 USP32 BARD1 CDC27 PPM1B	1.70e-05	481	59	7	28190767
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CDC37 PSME3IP1 ZBTB33 ANK2 MATR3 PGRMC2 CAST KMT2A UPF3B	2.64e-05	934	59	9	33916271
Pubmed	Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.	CDK8 BARD1 KMT2A	2.67e-05	34	59	3	12549820
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DCAF1 USP34 MATR3 PPP1R13B	2.70e-05	101	59	4	9872452
Pubmed	HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.	DCAF1 UBE2D2	2.82e-05	5	59	2	23612978
Pubmed	Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex.	UBE2D3 BARD1	2.82e-05	5	59	2	12732733
Pubmed	ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.	UBE2D2 UBE2D3	2.82e-05	5	59	2	16413270
Pubmed	E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).	UBE2D2 UBE2D3	2.82e-05	5	59	2	15684077
Pubmed	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	UBE2D2 UBE2D3	2.82e-05	5	59	2	26502057
Pubmed	The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.	UBE2D2 UBE2D3	2.82e-05	5	59	2	31929179
Pubmed	More than just water channels: unexpected cellular roles of aquaporins.	AQP7P3 AQP7	2.82e-05	5	59	2	16079275
Pubmed	Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.	UBE2D2 UBE2D3	2.82e-05	5	59	2	23509263
Pubmed	K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.	KCNA2 KCNB2	2.82e-05	5	59	2	2333511
Pubmed	Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.	UBE2D2 UBE2D3	2.82e-05	5	59	2	10329681
Pubmed	HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.	DCAF1 UBE2D2	2.82e-05	5	59	2	23677995
Pubmed	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.	UBE2D2 UBE2D3	2.82e-05	5	59	2	25327252
Pubmed	The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.	UBE2D2 UBE2D3	2.82e-05	5	59	2	14562029
Pubmed	Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.	UBE2D2 UBE2D3	2.82e-05	5	59	2	23408431
Pubmed	A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.	UBE2D2 UBE2D3	2.82e-05	5	59	2	18313049
Pubmed	Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.	UBE2D2 UBE2D3	2.82e-05	5	59	2	19741096
Pubmed	Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.	UBE2D2 UBE2D3	2.82e-05	5	59	2	8090726
Pubmed	Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.	DCAF1 UBE2D2 XPNPEP3	2.92e-05	35	59	3	19287380
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	USP34 ANK2 MATR3 CAST UPF3B CDC27 LARP7 MOV10 PPM1B	3.57e-05	971	59	9	33306668
Pubmed	Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	4.23e-05	6	59	2	9990509
Pubmed	UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.	UBE2D3 BARD1	4.23e-05	6	59	2	21532592
Pubmed	Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.	UBE2D2 UBE2D3	4.23e-05	6	59	2	27678051
Pubmed	BRCA1 ubiquitinates RPB8 in response to DNA damage.	UBE2D3 BARD1	4.23e-05	6	59	2	17283126
Pubmed	CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.	DCAF1 UBE2D3	4.23e-05	6	59	2	22570418
Pubmed	The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.	UBE2D3 BARD1	4.23e-05	6	59	2	20351172
Pubmed	Restricted expression of mouse GCMa/Gcm1 in kidney and thymus.	AQP7P3 AQP7	4.23e-05	6	59	2	12351183
Pubmed	HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.	DCAF1 UBE2D2	4.23e-05	6	59	2	20870715
Pubmed	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.	UBE2D2 UBE2D3	4.23e-05	6	59	2	22124327
Pubmed	Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.	UBE2D2 UBE2D3	4.23e-05	6	59	2	15280377
Pubmed	Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.	UBE2D2 UBE2D3	4.23e-05	6	59	2	28625874
Pubmed	h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.	UBE2D2 UBE2D3	4.23e-05	6	59	2	16549277
Pubmed	The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.	UBE2D2 UBE2D3	4.23e-05	6	59	2	25701873
Pubmed	Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.	CDC37 UBE2D2	4.23e-05	6	59	2	21860411
Pubmed	Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.	UBE2D2 UBE2D3	4.23e-05	6	59	2	22976837
Pubmed	HIV-1 Vpr Reprograms CLR4DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection.	DCAF1 UBE2D2	4.23e-05	6	59	2	30352932
Pubmed	NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.	UBE2D2 UBE2D3	4.23e-05	6	59	2	33962630
Pubmed	Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.	UBE2D2 UBE2D3	4.23e-05	6	59	2	30404641
Pubmed	Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.	UBE2D3 BARD1	5.91e-05	7	59	2	11927591
Pubmed	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	5.91e-05	7	59	2	20051513
Interaction	RBM3 interactions	USP34 MATR3 PAPSS2 LARP7 MOV10 OVOL2	6.59e-06	163	57	6	int:RBM3
Interaction	E2F2 interactions	ZFP91 PPP1R13B KMT2A MOV10	1.76e-05	55	57	4	int:E2F2
Interaction	CTNNB1 interactions	CDC37 HNF1B ZBTB33 ANK2 MATR3 PPP1R13B KMT2A CDC27 PICK1 MOV10 SFN OVOL2	2.03e-05	1009	57	12	int:CTNNB1
Interaction	RNF150 interactions	UBE2D2 UBE2D3 MOV10	2.36e-05	20	57	3	int:RNF150
Coexpression	GSE31082_CD4_VS_CD8_SP_THYMOCYTE_UP	PITPNM1 USP34 TRPM7 ZFP91 CAST UPF3B PPM1B	2.93e-07	200	58	7	M5069
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CDK8 USP34 UBE2D2 UBE2D3 TIAM1 MYO9B BARD1 CDC27 DENND2B PPM1B DOP1B	2.37e-06	856	58	11	M4500
Coexpression	GSE13522_WT_VS_IFNG_KO_SKING_T_CRUZI_Y_STRAIN_INF_DN	DCAF1 ANK2 XPNPEP3 DENND2B AQP7	9.20e-06	127	58	5	M2915
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HNF1B OVOL1 RBM47 SFN OVOL2	6.32e-06	197	59	5	a137412f29a06e29efe8a5dd641839ff2aeeda0c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HNF1B OVOL1 RBM47 SFN OVOL2	6.32e-06	197	59	5	c14dac1c8ba9d366d9dbefedb69f7b29d6fe6f4d
ToppCell	(08)_PNEC-(2)_48hpi\|(08)_PNEC / shred by cell type and Timepoint	CDK8 ARHGDIB CAST FRMD3	3.78e-05	142	59	4	e95d34170f5053678e0dd9793e68d93c03b05822
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EREG OVOL1 RBM47 SFN	4.56e-05	149	59	4	dede8ffc14ce63e0058bde1394b31bb4088996b3
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EREG OVOL1 RBM47 SFN	4.56e-05	149	59	4	97015942c4ac797e1c12a1673cd147c10450b15a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EREG OVOL1 RBM47 SFN	4.68e-05	150	59	4	65ad642cd237ba0db4bde7371533884db2fa0aae
ToppCell	droplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 KCNA2 ANK2 CC2D2A	6.02e-05	160	59	4	a494001b1f6dec33624f98fa3c24bad6988d0425
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGDIB DNAH17 SH2D4B SFN	7.11e-05	167	59	4	4520ee71e2b119c1dfa0e342fe57eda5f3598650
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY4 DENND2B PRR18 AQP7	8.15e-05	173	59	4	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZBTB33 PPP1R13B PPM1B DOP1B	9.29e-05	179	59	4	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	BNIP5 ANK2 FREM3 SFN	9.50e-05	180	59	4	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	3'_v3-GI_small-bowel-Myeloid_Monocytic-Nonclassical_monocytes\|GI_small-bowel / Manually curated celltypes from each tissue	PRAM1 EREG PAPSS2 RBM47	1.10e-04	187	59	4	c20689022569640ebc4a878e3fe146b86fe9b386
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HNF1B PPP1R13B RBM47 FRMD3	1.12e-04	188	59	4	beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	ANK2 TRPM7 PPP1R13B AQP7	1.15e-04	189	59	4	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ANK2 TRPM7 PPP1R13B AQP7	1.15e-04	189	59	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRAM1 EREG MYO9B RBM47	1.17e-04	190	59	4	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ANK2 TRPM7 PPP1R13B AQP7	1.17e-04	190	59	4	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 OTC MATR3 CAST	1.19e-04	191	59	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	ANK2 TRPM7 PPP1R13B AQP7	1.19e-04	191	59	4	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	PRAM1 TIAM1 MYO9B RBM47	1.19e-04	191	59	4	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 OTC MATR3 CAST	1.19e-04	191	59	4	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 KCNB2 ALK FRMD3	1.19e-04	191	59	4	9c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 OTC MATR3 CAST	1.19e-04	191	59	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRAM1 EREG TIAM1 RBM47	1.19e-04	191	59	4	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PRAM1 TIAM1 MYO9B RBM47	1.22e-04	192	59	4	bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	ANK2 TRPM7 PPP1R13B AQP7	1.22e-04	192	59	4	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HNF1B ANK2 RBM47 FRMD3	1.22e-04	192	59	4	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	USP34 MYO9B MATR3 RBM47	1.24e-04	193	59	4	779276e775cb2492e8dd36436295a536084a6415
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP34 ZBTB33 ZFP91 USP32	1.24e-04	193	59	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DENND2B ALK FRMD3	1.24e-04	193	59	4	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNIP5 OVOL1 RBM47 SFN	1.24e-04	193	59	4	930df79b0600f43617052313294be33bcf5631f0
ToppCell	RA-08._Macrophage\|World / Chamber and Cluster_Paper	EREG MYO9B PAPSS2 RBM47	1.24e-04	193	59	4	5fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OVOL1 CAST RBM47 SFN	1.24e-04	193	59	4	ee91a796d0f6d4cee7a93a525689e716fdceeda5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TIAM1 DENND2B ALK FRMD3	1.24e-04	193	59	4	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNIP5 OVOL1 RBM47 SFN	1.27e-04	194	59	4	07d8e38cbc2c7f0564c14f7c365f345f901b73b2
ToppCell	Control-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	EREG MYO9B PAPSS2 RBM47	1.27e-04	194	59	4	c35bf04d5e7450cb6679a036fcabb1b28f409f29
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OVOL1 RBM47 SFN OVOL2	1.32e-04	196	59	4	53dcac5e34c08c67a897dd5fbfbe88ea37e15585
ToppCell	IPF-Myeloid-Macrophage\|IPF / Disease state, Lineage and Cell class	EREG MYO9B PAPSS2 RBM47	1.34e-04	197	59	4	a2ffb33c7cad6be43cbb8ed9a91338923cc07db4
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRAM1 KCNA2 TIAM1 MYO9B	1.37e-04	198	59	4	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRAM1 KCNA2 TIAM1 MYO9B	1.37e-04	198	59	4	0baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OTC EREG OVOL1 SFN	1.37e-04	198	59	4	8e640e7b464c72ee41402f31dcc3b0032bdab277
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRAM1 EREG TIAM1 MYO9B	1.37e-04	198	59	4	623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OTC EREG OVOL1 SFN	1.40e-04	199	59	4	2f6cb5c9f08fc1b6b7771a0360c93a69a7319f13
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRAM1 EREG TIAM1 MYO9B	1.42e-04	200	59	4	fd72fe6565e2f4885481991492d58c323ab1ad40
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TIAM1 DENND2B ALK FRMD3	1.42e-04	200	59	4	6a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD14\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRAM1 EREG MYO9B RBM47	1.42e-04	200	59	4	5432bdf495431cd26f6e4cd585100f3652588913
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TIAM1 DENND2B ALK FRMD3	1.42e-04	200	59	4	347a510755374c6a66acee326565dfc447993f18
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TIAM1 DENND2B ALK FRMD3	1.42e-04	200	59	4	8d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCell	Bronchial-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRAM1 TIAM1 MYO9B RBM47	1.42e-04	200	59	4	2f5b71e55c2de0e77fdae6667eb57f333acc6cd1
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TIAM1 DENND2B ALK FRMD3	1.42e-04	200	59	4	cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
Disease	sinoatrial node disease (implicated_via_orthology)	ANK2 TRPM7	3.67e-06	2	57	2	DOID:0050824 (implicated_via_orthology)
Disease	Pilomatrixoma	OVOL1 OVOL2	2.19e-05	4	57	2	C0206711
Disease	acute myeloid leukemia (implicated_via_orthology)	ZFP91 KMT2A	2.39e-04	12	57	2	DOID:9119 (implicated_via_orthology)
Disease	hypertension	TIAM1 MYO9B RBM47 MOV10 FRMD3	3.17e-04	307	57	5	EFO_0000537
Disease	brain infarction	RBM47 ALK	5.50e-04	18	57	2	EFO_0004277
Disease	Ovarian Serous Adenocarcinoma	TRPM7 ALK	9.04e-04	23	57	2	C1335177
Disease	sensory peripheral neuropathy, remission	KMT2A PRR18	9.04e-04	23	57	2	EFO_0009785, MONDO_0002321

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLVPEELRVDYELPD	ACTL7B	271	Q9Y614
EQEEKYEIPEGPRRS	BARD1	646	Q99728
EEGSEEKGPEVREYR	SFN	71	P31947
EPTYLVIDPRAEEED	ADCY4	441	Q8NFM4
IVGDLPKENPYEDVD	DENND2B	491	P78524
EPIPEDIEDPKAYSI	CFAP44	911	Q96MT7
PEEVPEKRFQYDEET	CFAP44	1261	Q96MT7
RIIYEVEDPSKPNDE	PPP1R13B	906	Q96KQ4
GKIPRDVYEDELVPV	RBM47	76	A0AV96
PTGDDVDEQPVIYKE	ANK2	2796	Q01484
TGIDSDYEKPETPER	PAPSS2	176	O95340
TEEYRKGDPDPFDDR	DCAF1	46	Q9Y4B6
GYIKEEERPLPENEF	KCNA2	131	P16389
DLDELSRYPEDKITP	MATR3	121	P43243
TYDIVIPVKDDPDEG	ZBTB33	441	Q86T24
PREPLKLEDSVAYED	AQP7P3	281	A6NL99
PREPLKLEDSVAYED	AQP7B	286	A0A075B734
EKYPLRGELSEEELP	DOP1B	1076	Q9Y3R5
RKPEEVDDEVFYSPR	OTC	306	P00480
LKPGEEPSEYTDEED	PGRMC2	201	O15173
GERPKDEDERTVYVE	LARP7	116	Q4G0J3
PREPLKLEDSVAYED	AQP7	281	O14520
ELPDEKRADTYIPVG	OVOL2	21	Q9BRP0
ELPDEERGEIYVPVS	OVOL1	21	O14753
DEKPKRPEDESGRDY	UPF3B	331	Q9BZI7
AREYEDPPSEEEDKI	FRMD3	421	A2A2Y4
QEKPERPSAYEEEIE	KCNB2	561	Q92953
EPGEELPLDRASEYK	BNIP5	376	P0C671
EIAEPYPEEDLVKPS	CC2D2A	606	Q9P2K1
EIPEAVVTYEEKPRE	DNAH17	1671	Q9UFH2
EEYEFLTPVEEAPKG	ARHGDIB	151	P52566
GLDPVEVYESLPEEL	CDC37	291	Q16543
GEKEETIPPDYRLEE	CAST	471	P20810
RRFIEDEDYDPPIKI	KMT2A	426	Q03164
DEDYDPPIKIARLES	KMT2A	431	Q03164
EPKKEYERVTSGDPE	EREG	151	O14944
IPYPKREFLTEEEPD	CDK8	351	P49336
KRYLPDDEEPITQEE	CDC27	781	P30260
GEILLPREVPDEYEV	DKK3	296	Q9UBP4
YEEEPEAVDEGLVRK	PRR18	251	Q8N4B5
EDGDDYDTPPILKEL	HNF1B	81	P35680
PEAEYKIEEDIGELL	FREM3	1891	P0C091
IEEGERPDRAKGYDL	MOV10	271	Q9HCE1
RKPEDPEECPEEVYD	PSME3IP1	36	Q9GZU8
VPDEIYELYDDVEPR	PRAM1	501	Q96QH2
SPEPEVYEILRAEED	PPM1B	221	O75688
ALPIEYGPLVEEEEK	ALK	1396	Q9UM73
DAVAPGEYKAEEDPR	PITPNM1	146	O00562
DDPLVPEIARIYKTD	UBE2D2	116	P62837
EEGSPEKERPPEAEY	VGLL2	66	Q8N8G2
TYPELEEGVELLESP	TIAM1	926	Q13009
DDPLVPEIARIYKTD	UBE2D3	116	P61077
DPEREPVENEDYREK	ZNF200	166	P98182
EPGIYIPEDDKDAPE	XPNPEP3	451	Q9NQH7
PGDKPYEEISEELIA	SH2D4B	86	Q5SQS7
EEEIPFKDDPRDETY	ZFP91	221	Q96JP5
QALKPIRIDDYEEEP	USP34	1711	Q70CQ2
IRIDDYEEEPILKPG	USP34	1716	Q70CQ2
DYDIEEDKLGIPTVP	PICK1	6	Q9NRD5
EIVDIDDPETKRFPY	TRPM7	606	Q96QT4
EKPYVELKDSDGRPD	USP32	846	Q8NFA0
EKEDITYRLPELDPR	MYO9B	1976	Q13459