Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionorexin receptor activity

HCRTR1 HCRTR2

3.72e-062392GO:0016499
GeneOntologyMolecularFunctionserine-type endopeptidase activity

BMP1 TMPRSS5 TLL1 TLL2

5.03e-04190394GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

BMP1 TMPRSS5 TLL1 TLL2

6.94e-04207394GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

BMP1 TMPRSS5 TLL1 TLL2

7.59e-04212394GO:0017171
DomainBMP_1/tolloid-like

BMP1 TLL1 TLL2

7.77e-093383IPR015446
DomainPeptidase_M12A

BMP1 TLL1 TLL2

1.55e-076383IPR001506
DomainAstacin

BMP1 TLL1 TLL2

1.55e-076383PF01400
DomainOrexin_rcpt

HCRTR1 HCRTR2

4.03e-062382IPR000204
DomainZnMc

BMP1 TLL1 TLL2

2.74e-0529383SM00235
DomainPeptidase_Metallo

BMP1 TLL1 TLL2

2.74e-0529383IPR006026
DomainWD40_repeat_dom

WDR3 NBEA DCAF13 WDR17 WDR59 MAPK8IP3

2.77e-05297386IPR017986
Domain-

WDR3 NBEA DCAF13 WDR17 WDR59 MAPK8IP3

5.24e-053333862.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR3 NBEA DCAF13 WDR17 WDR59 MAPK8IP3

5.42e-05335386IPR015943
DomainCUB

BMP1 TLL1 TLL2

1.34e-0449383PF00431
DomainCUB

BMP1 TLL1 TLL2

1.43e-0450383SM00042
Domain-

BMP1 TLL1 TLL2

1.60e-04523832.60.120.290
DomainCUB

BMP1 TLL1 TLL2

1.70e-0453383PS01180
DomainWD40

WDR3 NBEA DCAF13 WDR17 WDR59

1.70e-04259385PF00400
DomainWD40

WDR3 NBEA DCAF13 WDR17 WDR59

2.00e-04268385SM00320
DomainCUB_dom

BMP1 TLL1 TLL2

2.11e-0457383IPR000859
DomainWD40_repeat

WDR3 NBEA DCAF13 WDR17 WDR59

2.14e-04272385IPR001680
DomainWD_REPEATS_1

WDR3 NBEA DCAF13 WDR17 WDR59

2.37e-04278385PS00678
DomainWD_REPEATS_2

WDR3 NBEA DCAF13 WDR17 WDR59

2.41e-04279385PS50082
DomainWD_REPEATS_REGION

WDR3 NBEA DCAF13 WDR17 WDR59

2.41e-04279385PS50294
DomainWD40_repeat_CS

WDR3 DCAF13 WDR17 WDR59

3.35e-04164384IPR019775
DomainMetalloPept_cat_dom

BMP1 TLL1 TLL2

5.94e-0481383IPR024079
Domain-

BMP1 TLL1 TLL2

5.94e-04813833.40.390.10
DomainEGF_CA

BMP1 TLL1 TLL2

7.08e-0486383PF07645
DomainApc4_WD40_dom

WDR3 WDR17

7.48e-0420382IPR024977
DomainANAPC4_WD40

WDR3 WDR17

7.48e-0420382PF12894
DomainEGF_Ca-bd_CS

BMP1 TLL1 TLL2

1.00e-0397383IPR018097
DomainZINC_PROTEASE

BMP1 TLL1 TLL2

1.03e-0398383PS00142
DomainEGF_CA

BMP1 TLL1 TLL2

1.07e-0399383PS01187
DomainEGF_3

BMP1 TLL1 TLL2 OTOG

1.29e-03235384PS50026
DomainEGF-type_Asp/Asn_hydroxyl_site

BMP1 TLL1 TLL2

1.30e-03106383IPR000152
DomainEGF-like_dom

BMP1 TLL1 TLL2 OTOG

1.59e-03249384IPR000742
DomainEGF_CA

BMP1 TLL1 TLL2

1.94e-03122383SM00179
DomainEGF-like_Ca-bd_dom

BMP1 TLL1 TLL2

2.03e-03124383IPR001881
DomainEGF

BMP1 TLL1 TLL2

2.13e-03126383PF00008
DomainConA-like_dom

FSD2 NBEA ADGRG4

9.92e-03219383IPR013320
DomainEGF

BMP1 TLL1 TLL2

1.20e-02235383SM00181
PathwayREACTOME_ANCHORING_FIBRIL_FORMATION

BMP1 TLL1 TLL2

5.72e-0615343M27161
PathwayREACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS

BMP1 TLL1 TLL2

1.02e-0518343M27164
PathwayREACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS

BMP1 TLL1 TLL2

1.02e-0518343MM14882
PathwayWP_SLEEP_REGULATION

CACNA1I HCRTR1 HCRTR2

1.02e-0438343M39504
PathwayREACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS

HCRTR1 HCRTR2

1.57e-048342M27291
PathwayREACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS

HCRTR1 HCRTR2

1.57e-048342MM14995
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

BMP1 TLL1 TLL2

2.33e-0450343MM14796
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

BMP1 TLL1 TLL2

4.19e-0461343M27103
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

BMP1 TLL1 TLL2

4.19e-0461343MM14637
PathwayREACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES

BMP1 TLL1 TLL2

5.53e-0467343M26999
PathwayREACTOME_COLLAGEN_FORMATION

BMP1 TLL1 TLL2

7.99e-0476343MM14573
PathwayREACTOME_COLLAGEN_FORMATION

BMP1 TLL1 TLL2

1.30e-0390343M631
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

NBEA ERBB4 GRIN3B

1.48e-0394343M2843
Pubmed

Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.

BMP1 TLL1 TLL2

1.30e-09339318824173
Pubmed

Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

BMP1 TLL1 TLL2

1.30e-08539310479448
Pubmed

Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis.

BMP1 TLL1

1.23e-06239233169406
Pubmed

Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants.

HCRTR1 HCRTR2

1.23e-06239215256537
Pubmed

Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1.

BMP1 TLL1

1.23e-0623928661043
Pubmed

Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.

HCRTR1 HCRTR2

1.23e-06239215797953
Pubmed

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.

HCRTR1 HCRTR2

1.23e-06239234475397
Pubmed

Orexin/hypocretin receptor chimaeras reveal structural features important for orexin peptide distinction.

HCRTR1 HCRTR2

1.23e-06239221510948
Pubmed

Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.

BMP1 TLL1

1.23e-0623927798260
Pubmed

Peripherally administered orexin improves survival of mice with endotoxin shock.

HCRTR1 HCRTR2

1.23e-06239228035899
Pubmed

G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.

HCRTR1 HCRTR2

1.23e-06239227237973
Pubmed

Comment on "Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2".

HCRTR1 HCRTR2

1.23e-06239226582896
Pubmed

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.

HCRTR1 HCRTR2

1.23e-06239226950369
Pubmed

Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.

HCRTR1 HCRTR2

1.23e-06239211723285
Pubmed

Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.

BMP1 TLL1

1.23e-06239228000152
Pubmed

Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.

HCRTR1 HCRTR2

1.23e-06239222389503
Pubmed

Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain Reaction.

HCRTR1 HCRTR2

1.23e-06239238199807
Pubmed

Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.

HCRTR1 HCRTR2

1.23e-06239221377495
Pubmed

Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy.

HCRTR1 HCRTR2

1.23e-06239218714784
Pubmed

Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.

HCRTR1 HCRTR2

1.23e-06239226447462
Pubmed

Cellular localization of orexin receptors in human pituitary.

HCRTR1 HCRTR2

1.23e-06239211443222
Pubmed

Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.

HCRTR1 HCRTR2

1.23e-06239227683906
Pubmed

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons.

HCRTR1 HCRTR2

1.23e-06239220576035
Pubmed

Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.

HCRTR1 HCRTR2

1.23e-06239224485472
Pubmed

Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice.

HCRTR1 HCRTR2

1.23e-06239221533254
Pubmed

Orexin 1 and 2 Receptors in the Prelimbic Cortex Modulate Threat Valuation.

HCRTR1 HCRTR2

1.23e-06239234126185
Pubmed

Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene.

HCRTR1 HCRTR2

1.23e-06239221666548
Pubmed

Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice.

HCRTR1 HCRTR2

1.23e-06239226996108
Pubmed

Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms.

HCRTR1 HCRTR2

1.23e-06239227988352
Pubmed

Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.

BMP1 TLL1

1.23e-06239220658214
Pubmed

Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.

TLL1 TLL2

1.23e-06239211313359
Pubmed

Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.

ERBB4 LHX8 LDB1

1.71e-062139324157949
Pubmed

Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus.

HCRTR1 HCRTR2

3.67e-06339225212464
Pubmed

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

HCRTR1 HCRTR2

3.67e-0633929491897
Pubmed

Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation.

BMP1 TLL1

3.67e-06339227847137
Pubmed

Obesity and the hypothalamus: novel peptides for new pathways.

HCRTR1 HCRTR2

3.67e-0633929491885
Pubmed

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.

HCRTR1 HCRTR2

3.67e-06339223034387
Pubmed

To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

HCRTR1 HCRTR2

3.67e-06339211283317
Pubmed

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

HCRTR1 HCRTR2

3.67e-0633929527442
Pubmed

Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy.

HCRTR1 HCRTR2

3.67e-06339229784823
Pubmed

Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors.

HCRTR1 HCRTR2

3.67e-06339224530395
Pubmed

Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19.

TLL1 TLL2

3.67e-06339210516436
Pubmed

Bone morphogenetic protein-1 processes probiglycan.

BMP1 TLL1

3.67e-06339210896944
Pubmed

Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.

HCRTR1 HCRTR2

3.67e-06339226907809
Pubmed

Genetic analysis of the role of proteolysis in the activation of latent myostatin.

BMP1 TLL2

3.67e-06339218286185
Pubmed

Internal and external modulation factors of the orexin system (REVIEW).

HCRTR1 HCRTR2

3.67e-06339237054895
Pubmed

Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase.

BMP1 TLL1

3.67e-06339220043912
Pubmed

Hypocretin/orexin, sleep and narcolepsy.

HCRTR1 HCRTR2

3.67e-06339211340621
Pubmed

Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.

HCRTR1 HCRTR2

3.67e-06339221525292
Pubmed

Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.

BMP1 TLL1

3.67e-06339216507574
Pubmed

Absence of mutations in HCRT, HCRTR1 and HCRTR2 in patients with ROHHAD.

HCRTR1 HCRTR2

3.67e-06339226555080
Pubmed

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.

BMP1 TLL1

3.67e-06339219079247
Pubmed

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models.

HCRTR1 HCRTR2

3.67e-06339228507129
Pubmed

Is HCRTR2 a genetic risk factor for Alzheimer's disease?

HCRTR1 HCRTR2

3.67e-06339224969517
Pubmed

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.

HCRTR1 HCRTR2

3.67e-06339210973318
Pubmed

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.

BMP1 TLL1

3.67e-06339224419319
Pubmed

Differential Roles of Each Orexin Receptor Signaling in Obesity.

HCRTR1 HCRTR2

3.67e-06339231546102
Pubmed

Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.

BMP1 TLL1

3.67e-06339212808086
Pubmed

BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.

BMP1 TLL1

3.67e-06339228068493
Pubmed

Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.

HCRTR1 HCRTR2

3.67e-06339224794976
Pubmed

A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.

BMP1 HR

3.67e-0633921537334
Pubmed

Association between major mood disorders and the hypocretin receptor 1 gene.

HCRTR1 HCRTR2

3.67e-06339221071097
Pubmed

Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.

HCRTR1 HCRTR2

3.67e-06339234472713
Pubmed

Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.

HCRTR1 HCRTR2

3.67e-06339231983458
Pubmed

The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.

HCRTR1 HCRTR2

3.67e-06339230326460
Pubmed

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation.

HCRTR1 HCRTR2

3.67e-06339224005305
Pubmed

Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.

BMP1 TLL1

3.67e-06339232209430
Pubmed

The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.

BMP1 TLL1

7.34e-06439210331975
Pubmed

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.

HCRTR1 HCRTR2

7.34e-06439233247179
Pubmed

Mammalian tolloid proteinases: role in growth factor signalling.

TLL1 TLL2

7.34e-06439227391803
Pubmed

Hypothalamic orexin prevents hepatic insulin resistance via daily bidirectional regulation of autonomic nervous system in mice.

HCRTR1 HCRTR2

7.34e-06439225249578
Pubmed

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states.

HCRTR1 HCRTR2

7.34e-06439219694625
Pubmed

Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.

HCRTR1 HCRTR2

7.34e-06439215070969
Pubmed

Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.

HCRTR1 HCRTR2

7.34e-06439215978554
Pubmed

BMP1-like proteinases are essential to the structure and wound healing of skin.

BMP1 TLL1

7.34e-06439227363389
Pubmed

Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.

HCRTR1 HCRTR2

1.22e-05539222028875
Pubmed

PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.

BMP1 TLL1

1.22e-05539212393877
Pubmed

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

HCRTR1 HCRTR2

1.22e-0553929419374
Pubmed

Narcolepsy-cataplexy and schizophrenia in adolescents.

HCRTR1 HCRTR2

1.22e-05539224268496
Pubmed

Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes.

HCRTR1 HCRTR2

1.83e-05639221378163
Pubmed

Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes.

LHX8 LDB1

3.42e-05839224763339
Pubmed

Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.

HCRTR1 HCRTR2

3.42e-05839227631554
Pubmed

An interspecific backcross linkage map of the proximal half of mouse chromosome 14.

BMP1 HR

5.48e-05103921971251
Pubmed

The imprinted gene Magel2 regulates normal circadian output.

HCRTR1 HCRTR2

5.48e-051039217893678
Pubmed

HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.

BAK1 GRIN3B

6.70e-051139224739951
Pubmed

Chromosomal localization of three pulmonary surfactant protein genes in the mouse.

BMP1 HR

9.48e-05133921346779
Pubmed

Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.

BMP1 TLL1

1.85e-041839219914233
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RDH10 FYCO1 SYNE3 WDR59 MCM3AP MAPK8IP3 HR

2.03e-04110539735748872
Pubmed

Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

ERBB4 LHX8

2.07e-041939229474907
Pubmed

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.

BAK1 MCM3AP

2.07e-041939223666240
Pubmed

Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.

ERBB4 LHX8

3.05e-042339225875176
Pubmed

KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.

BMP1 ERBB4

3.05e-042339228164238
Pubmed

LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.

LHX8 LDB1

3.62e-042539219304889
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

WDR3 NBEA LDB1 WDR17 WDR59 MAPK8IP3 ZBTB43

5.04e-04128539735914814
Pubmed

FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex.

BMP1 LHX8

8.84e-043939233580754
Pubmed

Common genetic variation and the control of HIV-1 in humans.

NBEA HCRTR2

9.30e-044039220041166
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

DCAF13 SYNE3 TRPM3 ZBTB43 OTOG

9.92e-0468939536543142
Pubmed

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

FYCO1 LDB1 MAPK8IP3

1.09e-0318039330110629
CytobandEnsembl 112 genes in cytogenetic band chr8p21

BMP1 HR

5.92e-03135392chr8p21
GeneFamilyBone morphogenetic proteins|Astacins

BMP1 TLL1 TLL2

1.00e-076323894
GeneFamilyHypocretin receptors

HCRTR1 HCRTR2

3.03e-062322228
GeneFamilyWD repeat domain containing

WDR3 NBEA DCAF13 WDR17 WDR59

8.99e-05262325362
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERBB4 CCDC178 MYO5B TRPM3 FARP1

6.04e-07187395d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NBEA ERBB4 TRPM3 FARP1 TLL1

8.00e-071983955fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FSD2 ERBB4 FYCO1 GPX3

1.83e-05180394806e2f6138b630b9d7c41df75ec208e0a2298ee0
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NBEA ERBB4 FARP1 TLL1

1.91e-05182394215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RDH10 ERBB4 MYO5B TLL1

2.03e-05185394492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

MYO5B TRPM3 FARP1 GPX3

2.12e-05187394d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RDH10 ERBB4 MYO5B TLL1

2.12e-051873948e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RDH10 ERBB4 MYO5B TLL1

2.17e-051883949655a4c47b644a870017d349b99063e17dbae572
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

MYO5B TRPM3 FARP1 GPX3

2.21e-051893940be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

NBEA ERBB4 FARP1 TLL1

2.26e-05190394756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

RDH10 NBEA ERBB4 MYO5B

2.26e-0519039451ca9ef4df3220487152fcf684147730637c7cc1
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

BMP1 ERBB4 MYO5B FARP1

2.30e-05191394e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NBEA ERBB4 FARP1 TLL1

2.30e-0519139423776c7302cead3881b39127398f3b3e0d27885e
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RDH10 NBEA GRIN3B MYO5B

2.35e-051923948899d81306770adda893b5e146df1253971754c5
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RDH10 NBEA GRIN3B MYO5B

2.35e-051923945fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 MYO5B TRPM3 FARP1

2.40e-051933943866667dd221612589ae50f5c52f73a183a49ce6
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE3 MYO5B FARP1 TLL2

2.40e-05193394010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

NBEA ERBB4 FARP1 TLL1

2.40e-051933942bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 MYO5B TRPM3 FARP1

2.40e-0519339482e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 MYO5B TRPM3 FARP1

2.45e-0519439493c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 CCDC178 MYO5B FARP1

2.45e-051943945eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC178 SAMD11 FARP1 GPX3

2.60e-05197394ea746772adb9df4ddb0508d4ef35f2027bf09c35
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RDH10 SAMD11 FARP1 GPX3

2.65e-0519839409be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NBEA ERBB4 TRPM3 TLL1

2.65e-051983946ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NBEA ERBB4 MYO5B FARP1

2.76e-05200394d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NBEA ERBB4 MYO5B FARP1

2.76e-052003940eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADGRG4 HCRTR1 HCRTR2

8.39e-05973930d68bf2dfb9c221375b70b055f735536afb18f65
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH2 TRPM3 OTOG

1.15e-04108393d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

LHX8 ADGRG4 HCRTR2

1.39e-04115393c724e8b1fddcefdaa8d247aaff68c986538068f7
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

FYCO1 DCLRE1B TLL2

1.95e-0412939364768adf23123b92280fb30eb85147cbee084ae0
ToppCellfacs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS5 TLL2 HCRTR2

2.48e-04140393115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCellfacs-Thymus-nan-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS5 TLL2 HCRTR2

2.48e-0414039322d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCellfacs-Thymus-nan-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS5 TLL2 HCRTR2

2.48e-0414039362d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LHX8 HCRTR1 GPX3

2.70e-04144393b622b605f7ec6083ec06c8ea0fd171e07c52f3de
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 CCDC178 TRPM3

2.86e-041473932885978bcfc5623967c0c1204dadf5c78c74a082
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Thalamus / BrainAtlas - Mouse McCarroll V32

CACNA1I HCRTR1 HCRTR2

2.92e-04148393afebb64365c94b9476494bffe7c364677f19c8cf
ToppCellThalamus-Neuronal-Inhibitory|Thalamus / BrainAtlas - Mouse McCarroll V32

CACNA1I HCRTR1 HCRTR2

2.92e-041483935f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RDH10 BAK1 TMPRSS5

2.98e-041493937e295b2b82dea0754e98f8cef788e2781e5d641f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RDH10 BAK1 TMPRSS5

2.98e-04149393b4f77dc5f9d08b249fe5cd9a0acf86308c528ef4
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 CCDC178 GPX3

3.10e-04151393090b067873740c282865e2d02cf47d5cb3dd7607
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NBEA ERBB4 HCRTR2

3.74e-041613933b5d7a3dab479c6959a428f3954dedd989900276
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

RDH10 NBEA TLL1

3.74e-041613932d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 FARP1 HCRTR2

3.88e-04163393cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIN3B WDR17 SAMD11

4.02e-041653931b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIN3B WDR17 SAMD11

4.02e-04165393b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.23e-041683937abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.38e-04170393417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.61e-0417339395c723b09254ae7131fe5ba0841472502e83269b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TLL1 HCRTR2

4.69e-0417439343c0e758fa8683708475aec846929ac70d41d7f5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.69e-04174393e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS5 TRPM3 TLL2

4.69e-04174393667035a11b68745fa8446d6c68214713be42710f
ToppCellCOVID-19-kidney-REN+Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

DGKG NBEA TRPM3

4.69e-041743938393f0b43c767839c1630bcb952d62b42efc788d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.77e-0417539390e29945aa861082c94bb4f331161adc3a6ef899
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D3|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

NBEA MYO5B FARP1

4.85e-04176393bd5c85b3a4fb88ffe156599f6d224aa7664a513a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.85e-0417639372a2a01618ce836bc843395d5095e9090759b4a6
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

ERBB4 TRPM3 GPX3

4.85e-0417639336f77d878a53b30465b0dea8333a3865dba75613
ToppCellfacs-Skin-nan-18m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC178 NDUFA6 TLL2

4.85e-04176393086197acbfec4ac0c15b7e9721871aaa9e32e219
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.85e-04176393e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MYO5B TRPM3

4.93e-041773932b675840b7d2bb536c2c600936733bd9e97e7120
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NBEA ERBB4 TLL1

4.93e-04177393a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MYO5B TRPM3

4.93e-041773935e0fca9bd5e5ffe6d39f5bcd81f36512f3b0cb1b
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FSD2 ERBB4 GPX3

4.93e-04177393675003fbecee1b86919d1a6eeb268e1ca298f714
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FSD2 ERBB4 GPX3

4.93e-0417739372d144289167f200ac9f006d130de31e45568484
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

4.93e-041773934c069f0d044a96118090b85ca592a21d6b5d9399
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NBEA ERBB4 TLL1

4.93e-04177393363e07b0f347f3716d530a28ead854b98e27d37c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-2_PVALB_TAC1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MYO5B OTOG

5.01e-041783931985271984e6747941c8d2097d9c58f0260f021a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

5.01e-04178393431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCellPCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TMPRSS5 ERBB4 TRPM3

5.01e-0417839338ffbd01230c99f52274424ee6c172381daffc73
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

ERBB4 FARP1 TLL1

5.01e-0417839335a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TMPRSS5 ERBB4 TRPM3

5.09e-04179393df6d2cdc4e204ce1a4628dc71dfbc5e6c6309b2a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 MYO5B FARP1

5.09e-04179393cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

5.09e-04179393f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO5B TRPM3 FARP1

5.18e-04180393864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS5 ERBB4 TRPM3

5.18e-0418039338490017dd590e3fcfa7e88d8d15235d55f90cf1
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO5B TRPM3 FARP1

5.18e-04180393358923e4228035a3e90e2957392089219e90dcd7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MYO5B TRPM3

5.26e-04181393af92b8b7f455210dab502ef6964f3a0162180759
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO5B TRPM3 FARP1

5.26e-04181393b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.26e-04181393fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell3'_v3-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac|lymph-node_spleen / Manually curated celltypes from each tissue

BAK1 DCLRE1B GPX3

5.35e-0418239384018a84e1aa52fa52ccfc26db9cd1fb6d535b31
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.35e-04182393bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 MYO5B TRPM3

5.35e-04182393d4cb23b5a974c096a0ce84b47fe351eef44894d7
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.35e-04182393f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DGKG TRPM3 TLL2

5.35e-041823937b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCellPCW_05-06-Neuronal-Neuronal_SCP|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.35e-04182393b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 FARP1 GPX3

5.35e-041823934a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERBB4 CCDC178 TRPM3

5.35e-041823939d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRPM3 SAMD11 GPX3

5.43e-041833932beb5414958d38a5341870d55229f3b1707e76bf
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.43e-04183393e0854864d377e158a4793088d1cb6b3dbf2c805d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKG TRPM3 HCRTR2

5.43e-0418339365f2a5895d166189a095cf7ea9dda171f0419b08
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO5B TRPM3 FARP1

5.52e-0418439342ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.61e-0418539356c7a0dbf141728ac76b8c90af197719942ca67c
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPM3 FARP1 GPX3

5.61e-041853931bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKG CACNA1I TLL1

5.61e-0418539370de48988c1f8e0809afc8092b663aa439d8e528
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 TRPM3 HCRTR1

5.61e-04185393a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SAMD11 ADGRG4 HR

5.61e-04185393eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH2 ERBB4 GRIN3B

5.61e-041853935e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RDH10 TRPM3 SAMD11

5.69e-04186393aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMPRSS5 TRPM3 TLL2

5.69e-041863936f88b68735d0f7c9904eb8413e6007910d556185
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB4 CCDC178 TRPM3

5.69e-0418639308632045d499e61dd96ff29a5a9a208afe58dc58
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKG CACNA1I TLL1

5.69e-04186393d6c8ce2a32c218dcc63d861cc247152430ed3c8c
DrugViomycin sulfate [37883-00-4]; Up 200; 5.2uM; MCF7; HT_HG-U133A

BMP1 CACNA1I LDB1 TRPM3 WDR59 MAPK8IP3

1.06e-061993963541_UP
Drugmilnacipran

HCRTR1 HCRTR2

1.71e-054392ctd:C048107
DrugFlurandrenolide [1524-88-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A

CACNA1I WDR59 MCM3AP MAPK8IP3 HR

1.99e-051953956039_UP
DrugMeclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; HL60; HT_HG-U133A

DGKG BMP1 LDB1 MAPK8IP3 ZBTB43

2.04e-051963952424_DN
DrugEthosuximide [77-67-8]; Up 200; 28.4uM; PC3; HT_HG-U133A

CACNA1I LDB1 MAPK8IP3 ZBTB43 HR

2.25e-052003952116_UP
DiseaseHIV-1 infection

NBEA WDR59 HCRTR2

2.75e-0498383EFO_0000180
Diseasemood instability measurement

TMPRSS5 FARP1 GPX3

6.02e-04128383EFO_0008475
DiseaseGlobal developmental delay

NBEA TRPM3 MAPK8IP3

6.73e-04133383C0557874
DiseaseMalignant neoplasm of liver

MYO5B WDR17 GPX3

8.14e-04142383C0345904
DiseaseLiver neoplasms

MYO5B WDR17 GPX3

8.14e-04142383C0023903
Diseaseneuroticism measurement

TMPRSS5 ERBB4 SYNE3 LHX8 FARP1 HCRTR1

9.99e-04909386EFO_0007660
Diseasediverticulitis

NBEA LHX8

1.05e-0337382EFO_1001460
Diseasetesticular carcinoma

BAK1 MCM3AP

1.22e-0340382EFO_0005088
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

ERBB4 GPX3

1.54e-0345382DOID:3748 (is_implicated_in)
Diseaseglucose-dependent insulinotropic peptide measurement

NBEA APCDD1

2.14e-0353382EFO_0008464
Diseasedepressive symptom measurement

TMPRSS5 ERBB4 LHX8 FARP1

2.14e-03426384EFO_0007006
Diseasesusceptibility to hepatitis B infection measurement

MYO5B WDR17

3.10e-0364382EFO_0008405
Diseaseobstructive sleep apnea

DGKG LHX8

3.29e-0366382EFO_0003918
Diseasecoronary artery disease

BMP1 ERBB4 DCLRE1B TRPM3 FARP1 MAPK8IP3

3.94e-031194386EFO_0001645
DiseaseTesticular Germ Cell Tumor

BAK1 MCM3AP

4.01e-0373382EFO_1000566

Protein segments in the cluster

PeptideGeneStartEntry
WMALECIHYRKFTHQ

ERBB4

886

Q15303
RFVVDFMLHHCIARW

BAK1

156

Q16611
HCVMKESVREQWQIH

ADGRG4

2986

Q8IZF6
MRWHHRTTVSNVKMD

GPX3

196

P22352
FRQAMRHWEKHTCVT

BMP1

151

P13497
AVDHMEICHSNMLRW

DCLRE1B

231

Q9H816
HTKRMQHVICVKWTS

DCAF13

321

Q9NV06
HHSIRCMAVVYDRVW

MAPK8IP3

1046

Q9UPT6
MMRIKTWHFSIRQHR

LDB1

191

Q86U70
DCKREFSWMVRRHHC

FYCO1

1181

Q9BQS8
LLHMHRNWKRSTECA

MCM3AP

1826

O60318
QRRMHTLWQEHFKLV

CCDC178

801

Q5BJE1
AMHQVWVKFDIRGHC

HR

676

O43593
VWKQRTHVMRFFHET

NDUFA6

96

P56556
VWFQNCRARHKKHVS

LHX8

271

Q68G74
LVCLAVWRNHHMRTV

HCRTR1

66

O43613
CVAVWKNHHMRTVTN

HCRTR2

76

O43614
VTARHCVWCRMTFHR

DGKG

361

P49619
MVHVCWHRNTSVSMV

FARP1

911

Q9Y4F1
RSDCMAANYRWVHHK

CACNA1I

1346

Q9P0X4
KSAWRAFKESQCHHM

APCDD1

41

Q8J025
HRKVAQIFVTMHWSV

DNAH2

2946

Q9P225
VAMCHKFHVCIEWRR

OTOG

2351

Q6ZRI0
WMSRLHFCDSNVVRH

OR8H1

161

Q8NGG4
QVHMSRHFKVWSLRR

GRIN3B

361

O60391
AMRHWEKHTCVTFIE

TLL1

181

O43897
ETVTYMTHCHSRIEW

SYNE3

96

Q6ZMZ3
HVWRSHSTKSVMDFV

NBEA

1356

Q8NFP9
WCMRHTFASSRHKYE

FSD2

656

A1L4K1
IMKRRVHTHWDVNIS

SAMD11

81

Q96NU1
ICMFRWHTHQKGKVV

WDR17

176

Q8IZU2
LIERTMMVNCHAHFW

RDH10

161

Q8IZV5
NICAKRFMWRDSFHR

ZBTB43

431

O43298
RFMWRDSFHRHVTSC

ZBTB43

436

O43298
MIFQHLCCRWRKHES

TRPM3

1181

Q9HCF6
RWVVTAAHCMHSFRL

TMPRSS5

251

Q9H3S3
KQAMRHWEKHTCVTF

TLL2

181

Q9Y6L7
HTSHMMEWFRTQEVC

WDR59

946

Q6PJI9
QHCFKTMVGHRTEVW

WDR3

181

Q9UNX4
SCKHWVRHCEAMETR

UHRF1BP1

376

Q6BDS2
TIQKHVRGWMARRHF

MYO5B

866

Q9ULV0