| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | voltage-gated sodium channel activity | 1.45e-07 | 26 | 37 | 4 | GO:0005248 | |
| GeneOntologyMolecularFunction | intracellularly ligand-gated monoatomic ion channel activity | 3.93e-07 | 33 | 37 | 4 | GO:0005217 | |
| GeneOntologyMolecularFunction | intracellularly cAMP-activated cation channel activity | 6.97e-07 | 10 | 37 | 3 | GO:0005222 | |
| GeneOntologyMolecularFunction | intracellularly cyclic nucleotide-activated monoatomic cation channel activity | 1.65e-06 | 13 | 37 | 3 | GO:0005221 | |
| GeneOntologyMolecularFunction | cyclic nucleotide-activated monoatomic ion channel activity | 1.65e-06 | 13 | 37 | 3 | GO:0043855 | |
| GeneOntologyMolecularFunction | sodium channel activity | 2.53e-06 | 52 | 37 | 4 | GO:0005272 | |
| GeneOntologyMolecularFunction | monoatomic cation channel activity | 2.74e-06 | 343 | 37 | 7 | GO:0005261 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic cation channel activity | 5.74e-06 | 140 | 37 | 5 | GO:0099094 | |
| GeneOntologyMolecularFunction | voltage-gated monoatomic cation channel activity | 8.57e-06 | 152 | 37 | 5 | GO:0022843 | |
| GeneOntologyMolecularFunction | cAMP binding | 1.31e-05 | 25 | 37 | 3 | GO:0030552 | |
| GeneOntologyMolecularFunction | sodium ion transmembrane transporter activity | 1.52e-05 | 171 | 37 | 5 | GO:0015081 | |
| GeneOntologyMolecularFunction | monoatomic ion channel activity | 1.84e-05 | 459 | 37 | 7 | GO:0005216 | |
| GeneOntologyMolecularFunction | metal ion transmembrane transporter activity | 2.00e-05 | 465 | 37 | 7 | GO:0046873 | |
| GeneOntologyMolecularFunction | voltage-gated monoatomic ion channel activity | 2.05e-05 | 182 | 37 | 5 | GO:0005244 | |
| GeneOntologyMolecularFunction | voltage-gated channel activity | 2.16e-05 | 184 | 37 | 5 | GO:0022832 | |
| GeneOntologyMolecularFunction | monoatomic cation transmembrane transporter activity | 2.36e-05 | 664 | 37 | 8 | GO:0008324 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic ion channel activity | 2.72e-05 | 193 | 37 | 5 | GO:0015276 | |
| GeneOntologyMolecularFunction | ligand-gated channel activity | 3.00e-05 | 197 | 37 | 5 | GO:0022834 | |
| GeneOntologyMolecularFunction | gated channel activity | 3.14e-05 | 334 | 37 | 6 | GO:0022836 | |
| GeneOntologyMolecularFunction | voltage-gated potassium channel activity | 3.72e-05 | 102 | 37 | 4 | GO:0005249 | |
| GeneOntologyMolecularFunction | channel activity | 4.33e-05 | 525 | 37 | 7 | GO:0015267 | |
| GeneOntologyMolecularFunction | passive transmembrane transporter activity | 4.38e-05 | 526 | 37 | 7 | GO:0022803 | |
| GeneOntologyMolecularFunction | cyclic nucleotide binding | 5.11e-05 | 39 | 37 | 3 | GO:0030551 | |
| GeneOntologyMolecularFunction | monoatomic ion transmembrane transporter activity | 8.28e-05 | 793 | 37 | 8 | GO:0015075 | |
| GeneOntologyMolecularFunction | potassium channel activity | 9.03e-05 | 128 | 37 | 4 | GO:0005267 | |
| GeneOntologyMolecularFunction | inorganic cation transmembrane transporter activity | 1.32e-04 | 627 | 37 | 7 | GO:0022890 | |
| GeneOntologyMolecularFunction | potassium ion transmembrane transporter activity | 2.51e-04 | 167 | 37 | 4 | GO:0015079 | |
| GeneOntologyMolecularFunction | inorganic molecular entity transmembrane transporter activity | 4.20e-04 | 758 | 37 | 7 | GO:0015318 | |
| GeneOntologyMolecularFunction | transmembrane transporter activity | 1.21e-03 | 1180 | 37 | 8 | GO:0022857 | |
| GeneOntologyMolecularFunction | transporter activity | 2.12e-03 | 1289 | 37 | 8 | GO:0005215 | |
| GeneOntologyMolecularFunction | miRNA binding | 3.57e-03 | 48 | 37 | 2 | GO:0035198 | |
| GeneOntologyMolecularFunction | regulatory RNA binding | 5.89e-03 | 62 | 37 | 2 | GO:0061980 | |
| GeneOntologyMolecularFunction | double-stranded RNA binding | 9.18e-03 | 78 | 37 | 2 | GO:0003725 | |
| GeneOntologyMolecularFunction | RNA endonuclease activity | 9.41e-03 | 79 | 37 | 2 | GO:0004521 | |
| GeneOntologyBiologicalProcess | lymphocyte chemotaxis across high endothelial venule | 2.96e-06 | 2 | 36 | 2 | GO:0002518 | |
| GeneOntologyBiologicalProcess | response to purine-containing compound | 9.79e-06 | 166 | 36 | 5 | GO:0014074 | |
| GeneOntologyBiologicalProcess | siRNA-mediated gene silencing by mRNA destabilization | 1.77e-05 | 4 | 36 | 2 | GO:0090625 | |
| GeneOntologyBiologicalProcess | siRNA-mediated post-transcriptional gene silencing | 1.77e-05 | 4 | 36 | 2 | GO:0140766 | |
| GeneOntologyBiologicalProcess | action potential | 2.47e-05 | 201 | 36 | 5 | GO:0001508 | |
| GeneOntologyBiologicalProcess | cellular response to cGMP | 6.19e-05 | 7 | 36 | 2 | GO:0071321 | |
| GeneOntologyBiologicalProcess | RNA secondary structure unwinding | 1.06e-04 | 9 | 36 | 2 | GO:0010501 | |
| GeneOntologyBiologicalProcess | response to cGMP | 1.06e-04 | 9 | 36 | 2 | GO:0070305 | |
| GeneOntologyBiologicalProcess | response to organophosphorus | 1.07e-04 | 142 | 36 | 4 | GO:0046683 | |
| GeneOntologyBiologicalProcess | cellular response to cAMP | 1.08e-04 | 53 | 36 | 3 | GO:0071320 | |
| GeneOntologyBiologicalProcess | RISC complex assembly | 1.32e-04 | 10 | 36 | 2 | GO:0070922 | |
| GeneOntologyBiologicalProcess | regulation of humoral immune response | 1.56e-04 | 60 | 36 | 3 | GO:0002920 | |
| GeneOntologyBiologicalProcess | regulation of membrane depolarization | 1.64e-04 | 61 | 36 | 3 | GO:0003254 | |
| GeneOntologyBiologicalProcess | monoatomic cation transmembrane transport | 1.78e-04 | 942 | 36 | 8 | GO:0098655 | |
| GeneOntologyBiologicalProcess | positive regulation of T cell chemotaxis | 3.50e-04 | 16 | 36 | 2 | GO:0010820 | |
| GeneOntologyBiologicalProcess | regulation of membrane potential | 3.76e-04 | 559 | 36 | 6 | GO:0042391 | |
| GeneOntologyBiologicalProcess | pre-miRNA processing | 3.96e-04 | 17 | 36 | 2 | GO:0031054 | |
| GeneOntologyBiologicalProcess | sodium ion transmembrane transport | 4.60e-04 | 208 | 36 | 4 | GO:0035725 | |
| GeneOntologyBiologicalProcess | regulation of T cell chemotaxis | 5.52e-04 | 20 | 36 | 2 | GO:0010819 | |
| GeneOntologyBiologicalProcess | monoatomic ion transmembrane transport | 5.55e-04 | 1115 | 36 | 8 | GO:0034220 | |
| GeneOntologyBiologicalProcess | response to cAMP | 6.43e-04 | 97 | 36 | 3 | GO:0051591 | |
| GeneOntologyBiologicalProcess | positive regulation of lymphocyte chemotaxis | 6.69e-04 | 22 | 36 | 2 | GO:0140131 | |
| GeneOntologyBiologicalProcess | potassium ion transmembrane transport | 6.93e-04 | 232 | 36 | 4 | GO:0071805 | |
| GeneOntologyBiologicalProcess | monoatomic cation transport | 7.08e-04 | 1157 | 36 | 8 | GO:0006812 | |
| GeneOntologyBiologicalProcess | membrane depolarization during cardiac muscle cell action potential | 7.32e-04 | 23 | 36 | 2 | GO:0086012 | |
| GeneOntologyBiologicalProcess | inorganic cation transmembrane transport | 9.33e-04 | 922 | 36 | 7 | GO:0098662 | |
| GeneOntologyCellularComponent | HCN channel complex | 2.04e-08 | 4 | 37 | 3 | GO:0098855 | |
| GeneOntologyCellularComponent | voltage-gated potassium channel complex | 1.99e-05 | 91 | 37 | 4 | GO:0008076 | |
| GeneOntologyCellularComponent | potassium channel complex | 3.36e-05 | 104 | 37 | 4 | GO:0034705 | |
| GeneOntologyCellularComponent | cation channel complex | 5.59e-05 | 235 | 37 | 5 | GO:0034703 | |
| GeneOntologyCellularComponent | RISC-loading complex | 1.36e-04 | 10 | 37 | 2 | GO:0070578 | |
| GeneOntologyCellularComponent | dendritic shaft | 3.03e-04 | 74 | 37 | 3 | GO:0043198 | |
| GeneOntologyCellularComponent | monoatomic ion channel complex | 5.10e-04 | 378 | 37 | 5 | GO:0034702 | |
| GeneOntologyCellularComponent | endoribonuclease complex | 1.95e-03 | 37 | 37 | 2 | GO:1902555 | |
| GeneOntologyCellularComponent | transmembrane transporter complex | 2.16e-03 | 523 | 37 | 5 | GO:1902495 | |
| GeneOntologyCellularComponent | endonuclease complex | 2.63e-03 | 43 | 37 | 2 | GO:1905348 | |
| GeneOntologyCellularComponent | transporter complex | 2.69e-03 | 550 | 37 | 5 | GO:1990351 | |
| GeneOntologyCellularComponent | cell surface | 2.98e-03 | 1111 | 37 | 7 | GO:0009986 | |
| Domain | Ion_trans_N | 2.63e-08 | 4 | 36 | 3 | PF08412 | |
| Domain | Ion_trans_N | 2.63e-08 | 4 | 36 | 3 | IPR013621 | |
| Domain | K_chnl_volt-dep_EAG/ELK/ERG | 2.36e-06 | 14 | 36 | 3 | IPR003938 | |
| Domain | Ion_trans_dom | 2.51e-06 | 114 | 36 | 5 | IPR005821 | |
| Domain | Ion_trans | 2.51e-06 | 114 | 36 | 5 | PF00520 | |
| Domain | cNMP-bd_CS | 3.62e-06 | 16 | 36 | 3 | IPR018488 | |
| Domain | UPAR_LY6 | 7.33e-06 | 20 | 36 | 3 | PF00021 | |
| Domain | LY6_UPAR | 9.88e-06 | 22 | 36 | 3 | PS00983 | |
| Domain | LY6_UPA_recep-like | 9.88e-06 | 22 | 36 | 3 | IPR016054 | |
| Domain | Argonaute_N | 2.16e-05 | 4 | 36 | 2 | IPR032474 | |
| Domain | Argonaute_Mid_dom | 2.16e-05 | 4 | 36 | 2 | IPR032473 | |
| Domain | ArgoL2 | 2.16e-05 | 4 | 36 | 2 | IPR032472 | |
| Domain | ArgoN | 2.16e-05 | 4 | 36 | 2 | PF16486 | |
| Domain | ArgoMid | 2.16e-05 | 4 | 36 | 2 | PF16487 | |
| Domain | ArgoL2 | 2.16e-05 | 4 | 36 | 2 | PF16488 | |
| Domain | CNMP_BINDING_1 | 3.14e-05 | 32 | 36 | 3 | PS00888 | |
| Domain | CNMP_BINDING_2 | 3.14e-05 | 32 | 36 | 3 | PS00889 | |
| Domain | DUF1785 | 3.60e-05 | 5 | 36 | 2 | SM01163 | |
| Domain | cNMP | 3.78e-05 | 34 | 36 | 3 | SM00100 | |
| Domain | cNMP_binding | 3.78e-05 | 34 | 36 | 3 | PF00027 | |
| Domain | cNMP-bd_dom | 4.13e-05 | 35 | 36 | 3 | IPR000595 | |
| Domain | CNMP_BINDING_3 | 4.13e-05 | 35 | 36 | 3 | PS50042 | |
| Domain | cNMP-bd-like | 5.30e-05 | 38 | 36 | 3 | IPR018490 | |
| Domain | ArgoL1 | 5.39e-05 | 6 | 36 | 2 | PF08699 | |
| Domain | ArgoL1 | 5.39e-05 | 6 | 36 | 2 | IPR014811 | |
| Domain | CD59_antigen_CS | 5.39e-05 | 6 | 36 | 2 | IPR018363 | |
| Domain | PIWI | 1.00e-04 | 8 | 36 | 2 | PS50822 | |
| Domain | Piwi | 1.00e-04 | 8 | 36 | 2 | IPR003165 | |
| Domain | Piwi | 1.00e-04 | 8 | 36 | 2 | PF02171 | |
| Domain | Piwi | 1.00e-04 | 8 | 36 | 2 | SM00950 | |
| Domain | - | 1.07e-04 | 48 | 36 | 3 | 2.60.120.10 | |
| Domain | RmlC-like_jellyroll | 1.29e-04 | 51 | 36 | 3 | IPR014710 | |
| Domain | PAZ | 1.29e-04 | 9 | 36 | 2 | PS50821 | |
| Domain | PAZ_dom | 1.29e-04 | 9 | 36 | 2 | IPR003100 | |
| Domain | PAZ | 1.29e-04 | 9 | 36 | 2 | PF02170 | |
| Domain | PAZ | 1.29e-04 | 9 | 36 | 2 | SM00949 | |
| Domain | LU | 4.26e-04 | 16 | 36 | 2 | SM00134 | |
| Domain | DUF1605 | 4.82e-04 | 17 | 36 | 2 | IPR011709 | |
| Domain | OB_NTP_bind | 4.82e-04 | 17 | 36 | 2 | PF07717 | |
| Domain | HA2 | 5.42e-04 | 18 | 36 | 2 | PF04408 | |
| Domain | Helicase-assoc_dom | 5.42e-04 | 18 | 36 | 2 | IPR007502 | |
| Domain | HA2 | 5.42e-04 | 18 | 36 | 2 | SM00847 | |
| Domain | - | 3.70e-03 | 47 | 36 | 2 | 3.30.420.10 | |
| Domain | RNaseH-like_dom | 7.81e-03 | 69 | 36 | 2 | IPR012337 | |
| Domain | EGF_CA | 1.19e-02 | 86 | 36 | 2 | PF07645 | |
| Pathway | BIOCARTA_DICER_PATHWAY | 4.07e-05 | 5 | 29 | 2 | M22079 | |
| Pathway | REACTOME_POTASSIUM_CHANNELS | 4.56e-05 | 98 | 29 | 4 | MM14545 | |
| Pathway | REACTOME_POTASSIUM_CHANNELS | 5.55e-05 | 103 | 29 | 4 | M1073 | |
| Pathway | REACTOME_MICRORNA_MIRNA_BIOGENESIS | 6.10e-05 | 6 | 29 | 2 | MM14818 | |
| Pathway | REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS | 6.10e-05 | 6 | 29 | 2 | MM15083 | |
| Pathway | REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX | 7.92e-05 | 41 | 29 | 3 | M29748 | |
| Pathway | REACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS | 8.53e-05 | 7 | 29 | 2 | M46421 | |
| Pathway | REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS | 1.14e-04 | 8 | 29 | 2 | MM15082 | |
| Pathway | REACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS | 1.46e-04 | 9 | 29 | 2 | M27340 | |
| Pathway | REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION | 1.46e-04 | 9 | 29 | 2 | M27810 | |
| Pathway | REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION | 1.46e-04 | 9 | 29 | 2 | M46436 | |
| Pathway | REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS | 1.82e-04 | 10 | 29 | 2 | M48013 | |
| Pathway | REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION | 3.14e-04 | 13 | 29 | 2 | M46434 | |
| Pathway | PID_INTEGRIN5_PATHWAY | 5.45e-04 | 17 | 29 | 2 | M212 | |
| Pathway | REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY | 5.45e-04 | 17 | 29 | 2 | M27788 | |
| Pathway | WP_GENES_TARGETED_BY_MIRNAS_IN_ADIPOCYTES | 6.13e-04 | 18 | 29 | 2 | M39405 | |
| Pathway | REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS | 6.84e-04 | 19 | 29 | 2 | M48238 | |
| Pathway | REACTOME_MICRORNA_MIRNA_BIOGENESIS | 1.19e-03 | 25 | 29 | 2 | M712 | |
| Pathway | WP_TLR4_SIGNALING_AND_TOLERANCE | 1.49e-03 | 28 | 29 | 2 | M39561 | |
| Pathway | REACTOME_TGFBR3_EXPRESSION | 1.49e-03 | 28 | 29 | 2 | M48253 | |
| Pathway | REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION | 1.95e-03 | 32 | 29 | 2 | M48012 | |
| Pathway | REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY | 1.95e-03 | 32 | 29 | 2 | M27900 | |
| Pathway | WP_TOLLLIKE_RECEPTOR_SIGNALING | 2.07e-03 | 33 | 29 | 2 | MM15940 | |
| Pathway | REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4 | 2.20e-03 | 34 | 29 | 2 | M46422 | |
| Pathway | REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER | 2.33e-03 | 35 | 29 | 2 | M42525 | |
| Pathway | REACTOME_ONCOGENE_INDUCED_SENESCENCE | 2.33e-03 | 35 | 29 | 2 | M27190 | |
| Pathway | REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX | 2.60e-03 | 37 | 29 | 2 | M29790 | |
| Pubmed | 1.11e-09 | 3 | 37 | 3 | 33181864 | ||
| Pubmed | Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart. | 1.11e-09 | 3 | 37 | 3 | 22652004 | |
| Pubmed | 1.11e-09 | 3 | 37 | 3 | 21187420 | ||
| Pubmed | 1.11e-09 | 3 | 37 | 3 | 21945247 | ||
| Pubmed | 1.11e-09 | 3 | 37 | 3 | 22006928 | ||
| Pubmed | 4.43e-09 | 4 | 37 | 3 | 16043489 | ||
| Pubmed | 4.43e-09 | 4 | 37 | 3 | 9405696 | ||
| Pubmed | 4.43e-09 | 4 | 37 | 3 | 12928435 | ||
| Pubmed | 4.43e-09 | 4 | 37 | 3 | 21615589 | ||
| Pubmed | 4.43e-09 | 4 | 37 | 3 | 20140458 | ||
| Pubmed | 4.43e-09 | 4 | 37 | 3 | 22748890 | ||
| Pubmed | Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. | 4.43e-09 | 4 | 37 | 3 | 9630217 | |
| Pubmed | Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. | 1.11e-08 | 5 | 37 | 3 | 15564593 | |
| Pubmed | 1.11e-08 | 5 | 37 | 3 | 34429357 | ||
| Pubmed | 2.21e-08 | 6 | 37 | 3 | 25761792 | ||
| Pubmed | Transcription profiling of HCN-channel isotypes throughout mouse cardiac development. | 3.87e-08 | 7 | 37 | 3 | 19421833 | |
| Pubmed | 1.32e-07 | 10 | 37 | 3 | 16382102 | ||
| Pubmed | Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart. | 2.42e-07 | 12 | 37 | 3 | 17482496 | |
| Pubmed | Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart. | 4.00e-07 | 14 | 37 | 3 | 29107716 | |
| Pubmed | 5.00e-07 | 15 | 37 | 3 | 21147989 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 16806719 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 19524546 | ||
| Pubmed | Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4. | 1.10e-06 | 2 | 37 | 2 | 12813043 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 30877792 | ||
| Pubmed | Two pacemaker channels from human heart with profoundly different activation kinetics. | 1.10e-06 | 2 | 37 | 2 | 10228147 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 33233493 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 12034718 | ||
| Pubmed | HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease. | 1.10e-06 | 2 | 37 | 2 | 21076425 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 19171659 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 17261842 | ||
| Pubmed | Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels. | 1.10e-06 | 2 | 37 | 2 | 18579800 | |
| Pubmed | Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. | 1.10e-06 | 2 | 37 | 2 | 16777944 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 22094222 | ||
| Pubmed | Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels. | 1.10e-06 | 2 | 37 | 2 | 17548059 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 21456027 | ||
| Pubmed | Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. | 1.10e-06 | 2 | 37 | 2 | 11675786 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 17931874 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 12890777 | ||
| Pubmed | Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells. | 1.10e-06 | 2 | 37 | 2 | 12194012 | |
| Pubmed | Case-control pharmacogenetic study of HCN1/HCN2 variants and genetic generalized epilepsies. | 1.10e-06 | 2 | 37 | 2 | 29047147 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 12433951 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 15644313 | ||
| Pubmed | A leucine zipper motif essential for gating of hyperpolarization-activated channels. | 1.10e-06 | 2 | 37 | 2 | 23048023 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 15525777 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 22948144 | ||
| Pubmed | Functional heteromerization of HCN1 and HCN2 pacemaker channels. | 1.10e-06 | 2 | 37 | 2 | 11133998 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 29980633 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 32543742 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 11420311 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 19135060 | ||
| Pubmed | Processing of retinal signals in normal and HCN deficient mice. | 1.10e-06 | 2 | 37 | 2 | 22279546 | |
| Pubmed | Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels. | 1.10e-06 | 2 | 37 | 2 | 12562911 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 15687126 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 19570998 | ||
| Pubmed | Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells. | 1.10e-06 | 2 | 37 | 2 | 26995025 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 24638995 | ||
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 19574228 | ||
| Pubmed | Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression. | 1.10e-06 | 2 | 37 | 2 | 20130205 | |
| Pubmed | 1.10e-06 | 2 | 37 | 2 | 17553794 | ||
| Pubmed | 1.45e-06 | 21 | 37 | 3 | 30270038 | ||
| Pubmed | 3.30e-06 | 3 | 37 | 2 | 12856183 | ||
| Pubmed | Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. | 3.30e-06 | 3 | 37 | 2 | 22880098 | |
| Pubmed | HCN channels expressed in the inner ear are necessary for normal balance function. | 3.30e-06 | 3 | 37 | 2 | 22090507 | |
| Pubmed | 3.30e-06 | 3 | 37 | 2 | 16079136 | ||
| Pubmed | EP3 activation facilitates bladder excitability via HCN channels on ICCs. | 3.30e-06 | 3 | 37 | 2 | 28131828 | |
| Pubmed | 3.30e-06 | 3 | 37 | 2 | 15292205 | ||
| Pubmed | 3.30e-06 | 3 | 37 | 2 | 22662315 | ||
| Pubmed | Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins. | 3.30e-06 | 3 | 37 | 2 | 19946268 | |
| Pubmed | 3.30e-06 | 3 | 37 | 2 | 19471099 | ||
| Pubmed | A family of hyperpolarization-activated mammalian cation channels. | 3.30e-06 | 3 | 37 | 2 | 9634236 | |
| Pubmed | Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. | 4.41e-06 | 30 | 37 | 3 | 20080650 | |
| Pubmed | Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. | 4.88e-06 | 31 | 37 | 3 | 17473172 | |
| Pubmed | 6.35e-06 | 963 | 37 | 8 | 28671696 | ||
| Pubmed | 6.60e-06 | 4 | 37 | 2 | 25042871 | ||
| Pubmed | Molecular dissection of human Argonaute proteins by DNA shuffling. | 6.60e-06 | 4 | 37 | 2 | 23748378 | |
| Pubmed | Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. | 6.60e-06 | 4 | 37 | 2 | 26966193 | |
| Pubmed | 6.60e-06 | 4 | 37 | 2 | 32184125 | ||
| Pubmed | 6.60e-06 | 4 | 37 | 2 | 21593326 | ||
| Pubmed | Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. | 6.60e-06 | 4 | 37 | 2 | 15260970 | |
| Pubmed | 6.60e-06 | 4 | 37 | 2 | 18818380 | ||
| Pubmed | Slicing-independent RISC activation requires the argonaute PAZ domain. | 6.60e-06 | 4 | 37 | 2 | 22795694 | |
| Pubmed | 6.60e-06 | 4 | 37 | 2 | 19966796 | ||
| Pubmed | Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. | 6.60e-06 | 4 | 37 | 2 | 18771919 | |
| Pubmed | A Requirement for Argonaute 4 in Mammalian Antiviral Defense. | 6.60e-06 | 4 | 37 | 2 | 32049003 | |
| Pubmed | Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. | 9.11e-06 | 38 | 37 | 3 | 27098205 | |
| Pubmed | 1.10e-05 | 5 | 37 | 2 | 12526743 | ||
| Pubmed | 1.10e-05 | 5 | 37 | 2 | 19393748 | ||
| Pubmed | 1.10e-05 | 5 | 37 | 2 | 16177047 | ||
| Pubmed | Differential expression of components of the microRNA machinery during mouse organogenesis. | 1.10e-05 | 5 | 37 | 2 | 16036130 | |
| Pubmed | 1.10e-05 | 5 | 37 | 2 | 12414724 | ||
| Pubmed | 1.10e-05 | 5 | 37 | 2 | 19324964 | ||
| Pubmed | Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons. | 1.10e-05 | 5 | 37 | 2 | 30886335 | |
| Pubmed | Regulation of B1 cell migration by signals through Toll-like receptors. | 1.10e-05 | 5 | 37 | 2 | 17060475 | |
| Pubmed | Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. | 1.46e-05 | 139 | 37 | 4 | 16985003 | |
| Pubmed | 1.65e-05 | 6 | 37 | 2 | 12732660 | ||
| Pubmed | Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. | 1.65e-05 | 6 | 37 | 2 | 14517339 | |
| Pubmed | 1.65e-05 | 6 | 37 | 2 | 26005035 | ||
| Pubmed | 2.30e-05 | 7 | 37 | 2 | 27956497 | ||
| Pubmed | Functional dissection of the human TNRC6 (GW182-related) family of proteins. | 2.30e-05 | 7 | 37 | 2 | 19470757 | |
| Pubmed | 2.30e-05 | 7 | 37 | 2 | 34907157 | ||
| Interaction | HCN4 interactions | 4.36e-07 | 9 | 36 | 3 | int:HCN4 | |
| Interaction | HCN2 interactions | 1.48e-06 | 13 | 36 | 3 | int:HCN2 | |
| Interaction | PEX5L interactions | 2.54e-06 | 54 | 36 | 4 | int:PEX5L | |
| Interaction | KCNE2 interactions | 8.63e-05 | 8 | 36 | 2 | int:KCNE2 | |
| Interaction | MFAP5 interactions | 1.09e-04 | 52 | 36 | 3 | int:MFAP5 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr5p12 | 3.09e-04 | 32 | 37 | 2 | chr5p12 | |
| GeneFamily | Cyclic nucleotide gated channels | 4.42e-07 | 10 | 29 | 3 | 250 | |
| GeneFamily | CD molecules|Complement system|LY6/PLAUR domain containing | 2.15e-05 | 34 | 29 | 3 | 1226 | |
| GeneFamily | Argonaute/PIWI family | 6.91e-05 | 8 | 29 | 2 | 408 | |
| GeneFamily | ADAM metallopeptidase domain containing|CD molecules | 3.43e-03 | 394 | 29 | 4 | 471 | |
| ToppCell | PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09) | 2.78e-06 | 118 | 37 | 4 | f76fc6db7368a1e8e5e4f8535fc3dc78afe13b9b | |
| ToppCell | PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01) | 2.78e-06 | 118 | 37 | 4 | 0dcac16eea8e7978de370a815da9a0cdd212598e | |
| ToppCell | PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01) | 2.78e-06 | 118 | 37 | 4 | 7da3957d102e9f9825fc2609d6d0bd9ca6a3fba4 | |
| ToppCell | PBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09) | 2.78e-06 | 118 | 37 | 4 | c5c6724e0e526d7c2fc8cabff4a112a900ec997f | |
| ToppCell | Control-Lymphoid_T/NK-CD4+_T_activated|Control / Disease group, lineage and cell class | 2.87e-06 | 119 | 37 | 4 | d7352d0dafbb664619b7a1e3cd07b159fdfec197 | |
| ToppCell | PND01-03-samps-Mesenchymal-Pericyte|PND01-03-samps / Age Group, Lineage, Cell class and subclass | 7.58e-06 | 152 | 37 | 4 | fc9472bc19f997103da535b035105f01429cb08e | |
| ToppCell | 10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs|GI_large-bowel / Manually curated celltypes from each tissue | 9.75e-06 | 162 | 37 | 4 | 9a5e65c45f73a6a685b8362aa2e6aea77181caa3 | |
| ToppCell | facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.13e-05 | 168 | 37 | 4 | b96a48552f4236a95bbcdce2f1b05041086d7101 | |
| ToppCell | facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation | 1.13e-05 | 168 | 37 | 4 | b87fc63f9e35dfcfc46cb129ea569e73c5e018bb | |
| ToppCell | 10x3'2.3-week_14-16-Myeloid_macrophage-stroma-osteoclast|week_14-16 / cell types per 3 fetal stages;per 3',per 5' | 1.64e-05 | 185 | 37 | 4 | 5ed49b6d8214c6119355a6d3ee4e25d40bcc0c53 | |
| ToppCell | 10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast|week_12-13 / cell types per 3 fetal stages;per 3',per 5' | 1.68e-05 | 186 | 37 | 4 | c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68 | |
| ToppCell | PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif | 1.90e-05 | 192 | 37 | 4 | 158cc5736f154da1cb3186ffbf186eae10483e48 | |
| ToppCell | PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif | 1.90e-05 | 192 | 37 | 4 | f4ff62ac9c53eafbe917706de9af8b2d4bded4d4 | |
| ToppCell | Transverse-(5)_Dendritic_cell-(53)_Lymphoid_DC|Transverse / shred on region, Cell_type, and subtype | 2.10e-05 | 197 | 37 | 4 | 15b87fd3906d7388c271d30d0c64b1bcc490801c | |
| ToppCell | Transverse-T_cell-Treg|T_cell / Region, Cell class and subclass | 2.10e-05 | 197 | 37 | 4 | b7a1637e4baadd657f6279f4aa96cd590c9cd8c9 | |
| ToppCell | Transverse-Dendritic_cell-Lymphoid_DC|Transverse / Region, Cell class and subclass | 2.10e-05 | 197 | 37 | 4 | a58af0ea82f76f2a7abac1f62629ff20d552fc63 | |
| Drug | zatebradine | 2.64e-06 | 17 | 37 | 3 | CID000065637 | |
| Drug | HCNs | 4.42e-06 | 20 | 37 | 3 | CID006857665 | |
| Drug | zatebradine | 7.70e-06 | 3 | 37 | 2 | ctd:C043636 | |
| Drug | AC1NPPZW | 2.33e-05 | 103 | 37 | 4 | CID005183170 | |
| Drug | ivabradine | 3.47e-05 | 39 | 37 | 3 | CID000132999 | |
| Disease | meningitis (biomarker_via_orthology) | 1.21e-06 | 2 | 33 | 2 | DOID:9471 (biomarker_via_orthology) | |
| Disease | sick sinus syndrome (implicated_via_orthology) | 3.64e-06 | 3 | 33 | 2 | DOID:13884 (implicated_via_orthology) | |
| Disease | Abnormality of refraction | 8.50e-04 | 673 | 33 | 5 | HP_0000539 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| SDSSLVCSRYLQYCR | 141 | Q5NDL2 | |
| VETCCVIGNYYSLRS | 331 | Q9UJX2 | |
| YLTLCAGRRICSTYR | 61 | Q99944 | |
| SCTDHRYCQRKSYSL | 416 | Q9H5V8 | |
| RIFSKLTSYRDCCTA | 496 | Q8NEN0 | |
| LTSYRDCCTALASYS | 501 | Q8NEN0 | |
| DCCTALASYSRCYAL | 506 | Q8NEN0 | |
| TYQLCHTYVRCTRSV | 781 | Q9UL18 | |
| IAYDVTYSLACVRCC | 306 | P32248 | |
| YQLCHTYVRCTRSVS | 786 | Q9HCK5 | |
| TTRLRENELTYYCCK | 76 | P13987 | |
| ESRACESTRLLYCTT | 666 | Q7Z478 | |
| VYSITACRIDCETRY | 301 | Q16515 | |
| SIQCYLSALDRCYSV | 221 | Q01581 | |
| LYSYCRIVSSIRAIS | 216 | Q8NGA2 | |
| ALKCYSRARDYCTSA | 181 | Q13098 | |
| VSIASYSRVCRSYLC | 101 | Q6UWN0 | |
| VYYTSLRCRCVQESS | 26 | O43927 | |
| VAQLSSYCCYRSRRA | 621 | Q8TE96 | |
| ASVRADTYCRLYSLS | 671 | Q9Y3Q4 | |
| ASVRADTYCRLYSLS | 551 | O60741 | |
| YTCQCRAGYQSTLTR | 511 | P35555 | |
| SFFSLLTTCYARCRS | 191 | Q8N5C1 | |
| LTTCYARCRSKVSYL | 196 | Q8N5C1 | |
| CYCRALQAVTYRSAT | 681 | Q8TF61 | |
| YLASRSCQSSCYRPT | 151 | Q8IUC0 | |
| VQVSCYRTLCSIYSL | 3161 | P21817 | |
| SVRADTYCRLYSLSV | 621 | Q9UL51 | |
| ACCAVLSQESTRYLY | 41 | Q9NYJ8 | |
| CTISLCTYAASISYD | 221 | Q8NBL3 | |
| TSFTNRTYETYMCCR | 601 | O43868 | |
| AVTYSRSRYLECISC | 106 | Q03405 | |
| SSCSRYRSCYDCILA | 506 | Q9NTN9 | |
| HVLYVCAACERSYVT | 306 | Q9P1Z0 | |
| AISSVCTYIVYQCSR | 806 | Q86X10 | |
| LTATYRYILSCHCEE | 116 | Q00604 | |
| SDLIYRCRFCSYTSP | 921 | Q96JM2 | |
| VVCYACRIASTLLLY | 421 | Q9UHD2 | |
| TRDYICEFCARSFRT | 386 | Q9BU19 | |
| YSSVRYSDCCERVVI | 166 | P22459 |