Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.39e-05	2	75	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	1.39e-05	2	75	2	GO:0103002
GeneOntologyMolecularFunction	cytoskeletal protein binding	KIF20A CACNA1C DLG5 MYH13 SPTAN1 SYNE2 APC TRIOBP MACF1 PSTPIP2 JMY SMAD4 MPRIP	2.08e-04	1099	75	13	GO:0008092
GeneOntologyMolecularFunction	actin filament binding	MYH13 SPTAN1 TRIOBP MACF1 PSTPIP2 MPRIP	2.12e-04	227	75	6	GO:0051015
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	2.89e-04	7	75	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	2.89e-04	7	75	2	GO:0018685
GeneOntologyMolecularFunction	actin binding	MYH13 SPTAN1 SYNE2 TRIOBP MACF1 PSTPIP2 JMY MPRIP	4.27e-04	479	75	8	GO:0003779
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	6.14e-04	10	75	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	6.14e-04	10	75	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	6.14e-04	10	75	2	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	1.06e-03	13	75	2	GO:0016713
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	PLCL2 ITPR1	1.23e-03	14	75	2	GO:0070679
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	AGO2 CYFIP2	1.23e-03	14	75	2	GO:0000340
GeneOntologyMolecularFunction	arachidonate binding	CYP4A11 CYP4A22	1.42e-03	15	75	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4A11 CYP4A22	1.61e-03	16	75	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4A11 CYP4A22	1.61e-03	16	75	2	GO:0050543
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	RHPN1 DLG5 CARMIL2 TCHP IKBKE ARHGEF5 SPTAN1 SYNE2 VPS8 APC TRIOBP MACF1 TRIM65 TASOR CYFIP2 SMAD4	3.14e-06	1189	73	16	GO:0044087
GeneOntologyBiologicalProcess	lauric acid metabolic process	CYP4A11 CYP4A22	3.70e-05	3	73	2	GO:0048252
GeneOntologyBiologicalProcess	regulation of protein-containing complex assembly	CARMIL2 IKBKE ARHGEF5 SPTAN1 VPS8 APC TRIOBP TRIM65 CYFIP2	5.56e-05	489	73	9	GO:0043254
GeneOntologyBiologicalProcess	actin filament polymerization	CARMIL2 SPTAN1 TRIOBP TTC17 PSTPIP2 CYFIP2	5.76e-05	190	73	6	GO:0030041
GeneOntologyBiologicalProcess	growth hormone secretion	CACNA1C KALRN CHD7	6.24e-05	22	73	3	GO:0030252
GeneOntologyBiologicalProcess	negative regulation of cytoskeleton organization	RHPN1 CARMIL2 SPTAN1 APC TRIOBP SMAD4	6.46e-05	194	73	6	GO:0051494
GeneOntologyBiologicalProcess	negative regulation of supramolecular fiber organization	RHPN1 CARMIL2 SPTAN1 APC TRIOBP SMAD4	7.04e-05	197	73	6	GO:1902904
GeneOntologyBiologicalProcess	actin filament organization	RHPN1 CARMIL2 ARHGEF5 SPTAN1 TRIOBP TTC17 PSTPIP2 JMY CYFIP2	7.55e-05	509	73	9	GO:0007015
GeneOntologyBiologicalProcess	actin filament-based process	RHPN1 CACNA1C CARMIL2 ARHGEF5 SPTAN1 SYNE2 TRIOBP TTC17 PSTPIP2 JMY CYFIP2 SMAD4	7.93e-05	912	73	12	GO:0030029
GeneOntologyBiologicalProcess	negative regulation of organelle organization	RHPN1 CARMIL2 TCHP SPTAN1 APC TRIOBP SMAD4 KNL1	1.19e-04	421	73	8	GO:0010639
GeneOntologyBiologicalProcess	actin polymerization or depolymerization	CARMIL2 SPTAN1 TRIOBP TTC17 PSTPIP2 CYFIP2	1.36e-04	222	73	6	GO:0008154
GeneOntologyBiologicalProcess	regulation of actin filament-based process	RHPN1 CACNA1C CARMIL2 ARHGEF5 SPTAN1 TRIOBP CYFIP2 SMAD4	1.56e-04	438	73	8	GO:0032970
GeneOntologyBiologicalProcess	regulation of supramolecular fiber organization	RHPN1 CARMIL2 ARHGEF5 SPTAN1 APC TRIOBP CYFIP2 SMAD4	1.56e-04	438	73	8	GO:1902903
GeneOntologyBiologicalProcess	regulation of protein-containing complex disassembly	CARMIL2 SPTAN1 APC TRIOBP FYCO1	1.59e-04	144	73	5	GO:0043244
GeneOntologyBiologicalProcess	protein polymerization	CARMIL2 SPTAN1 APC TRIOBP TTC17 PSTPIP2 CYFIP2	1.79e-04	334	73	7	GO:0051258
GeneOntologyBiologicalProcess	negative regulation of protein depolymerization	CARMIL2 SPTAN1 APC TRIOBP	2.81e-04	89	73	4	GO:1901880
GeneOntologyBiologicalProcess	kidney development	RHPN1 DLG5 CYP4A11 APC LZTS2 SMAD4 CYP4A22	3.44e-04	372	73	7	GO:0001822
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by endoplasmic reticulum	CACNA1C CHD7 ITPR1	3.55e-04	39	73	3	GO:1903514
GeneOntologyBiologicalProcess	regulation of actin cytoskeleton organization	RHPN1 CARMIL2 ARHGEF5 SPTAN1 TRIOBP CYFIP2 SMAD4	4.16e-04	384	73	7	GO:0032956
GeneOntologyBiologicalProcess	renal system development	RHPN1 DLG5 CYP4A11 APC LZTS2 SMAD4 CYP4A22	4.29e-04	386	73	7	GO:0072001
GeneOntologyBiologicalProcess	negative regulation of protein-containing complex disassembly	CARMIL2 SPTAN1 APC TRIOBP	4.38e-04	100	73	4	GO:0043242
GeneOntologyCellularComponent	actin cytoskeleton	CARMIL2 MYH13 KALRN ARHGEF5 SPTAN1 TRIOBP MACF1 TTC17 PSTPIP2 MPRIP NCOA5	5.48e-06	576	74	11	GO:0015629
GeneOntologyCellularComponent	extrinsic component of membrane	ARHGEF40 CARMIL2 TRIO KALRN PIK3CG APC	1.65e-04	230	74	6	GO:0019898
GeneOntologyCellularComponent	postsynapse	CACNA1C DLG5 AGO2 AP2A1 TRIO KALRN SPTAN1 APC MACF1 PLCB3 GPR179 ITPR1	2.24e-04	1018	74	12	GO:0098794
Domain	Spectrin	TRIO KALRN SPTAN1 SYNE2 MACF1	2.19e-08	23	71	5	PF00435
Domain	Spectrin_repeat	TRIO KALRN SPTAN1 SYNE2 MACF1	7.61e-08	29	71	5	IPR002017
Domain	Spectrin/alpha-actinin	TRIO KALRN SPTAN1 SYNE2 MACF1	1.28e-07	32	71	5	IPR018159
Domain	SPEC	TRIO KALRN SPTAN1 SYNE2 MACF1	1.28e-07	32	71	5	SM00150
Domain	PH	ARHGEF40 TRIO KALRN ARHGEF5 PLCL2 TRIOBP MPRIP	8.85e-05	278	71	7	SM00233
Domain	PH_DOMAIN	ARHGEF40 TRIO KALRN ARHGEF5 PLCL2 TRIOBP MPRIP	9.05e-05	279	71	7	PS50003
Domain	PH_domain	ARHGEF40 TRIO KALRN ARHGEF5 PLCL2 TRIOBP MPRIP	9.26e-05	280	71	7	IPR001849
Domain	DH_1	ARHGEF40 TRIO KALRN ARHGEF5	9.64e-05	63	71	4	PS00741
Domain	-	ARHGEF40 TRIO KALRN ARHGEF5 PLCL2 TRIOBP PLCB3 MPRIP	1.16e-04	391	71	8	2.30.29.30
Domain	RhoGEF	ARHGEF40 TRIO KALRN ARHGEF5	1.45e-04	70	71	4	PF00621
Domain	DH_2	ARHGEF40 TRIO KALRN ARHGEF5	1.45e-04	70	71	4	PS50010
Domain	DH-domain	ARHGEF40 TRIO KALRN ARHGEF5	1.54e-04	71	71	4	IPR000219
Domain	-	ARHGEF40 TRIO KALRN ARHGEF5	1.54e-04	71	71	4	1.20.900.10
Domain	SH3	DLG5 TRIO KALRN ARHGEF5 SPTAN1 MACF1	1.71e-04	216	71	6	PS50002
Domain	SH3_domain	DLG5 TRIO KALRN ARHGEF5 SPTAN1 MACF1	1.89e-04	220	71	6	IPR001452
Domain	PH_dom-like	ARHGEF40 TRIO KALRN ARHGEF5 PLCL2 TRIOBP PLCB3 MPRIP	2.08e-04	426	71	8	IPR011993
Domain	BRK	CHD9 CHD7	2.12e-04	6	71	2	SM00592
Domain	BRK_domain	CHD9 CHD7	2.12e-04	6	71	2	IPR006576
Domain	BRK	CHD9 CHD7	2.12e-04	6	71	2	PF07533
Domain	SH3	DLG5 TRIO KALRN ARHGEF5 SPTAN1	1.38e-03	216	71	5	SM00326
Domain	PLipase_C_Pinositol-sp_Y	PLCL2 PLCB3	1.45e-03	15	71	2	IPR001711
Domain	EF-hand_like	PLCL2 PLCB3	1.45e-03	15	71	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCL2 PLCB3	1.45e-03	15	71	2	PS50008
Domain	PI-PLC_fam	PLCL2 PLCB3	1.45e-03	15	71	2	IPR001192
Domain	PLC_EF-hand-like	PLCL2 PLCB3	1.45e-03	15	71	2	IPR015359
Domain	PI-PLC-Y	PLCL2 PLCB3	1.45e-03	15	71	2	PF00387
Domain	PLCYc	PLCL2 PLCB3	1.45e-03	15	71	2	SM00149
Domain	PH	TRIO KALRN ARHGEF5 TRIOBP MPRIP	1.79e-03	229	71	5	PF00169
Domain	PI-PLC-X	PLCL2 PLCB3	2.10e-03	18	71	2	PF00388
Domain	PLCXc	PLCL2 PLCB3	2.10e-03	18	71	2	SM00148
Domain	RhoGEF	TRIO KALRN ARHGEF5	2.21e-03	68	71	3	SM00325
Domain	PIPLC_X_DOMAIN	PLCL2 PLCB3	2.34e-03	19	71	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCL2 PLCB3	2.34e-03	19	71	2	IPR000909
Domain	CRAL_TRIO	TRIO KALRN	2.86e-03	21	71	2	PF00650
Domain	Actinin_actin-bd_CS	SYNE2 MACF1	3.42e-03	23	71	2	IPR001589
Domain	-	TRIO KALRN	3.42e-03	23	71	2	3.40.525.10
Domain	ACTININ_2	SYNE2 MACF1	3.42e-03	23	71	2	PS00020
Domain	ACTININ_1	SYNE2 MACF1	3.42e-03	23	71	2	PS00019
Domain	Chromo_domain	CHD9 CHD7	3.73e-03	24	71	2	IPR023780
Domain	-	PLCL2 PLCB3	4.04e-03	25	71	2	3.20.20.190
Domain	SEC14	TRIO KALRN	4.04e-03	25	71	2	SM00516
Domain	PLC-like_Pdiesterase_TIM-brl	PLCL2 PLCB3	4.04e-03	25	71	2	IPR017946
Domain	Chromo	CHD9 CHD7	4.37e-03	26	71	2	PF00385
Domain	Kinase-like_dom	TRIO KALRN IKBKE PIK3CG MACF1 CHD9 STK35	4.46e-03	542	71	7	IPR011009
Domain	CRAL_TRIO	TRIO KALRN	4.70e-03	27	71	2	PS50191
Domain	EF-hand-dom_pair	CACNA1C SPTAN1 PLCL2 MACF1 PLCB3	4.72e-03	287	71	5	IPR011992
Domain	CHROMO_1	CHD9 CHD7	5.05e-03	28	71	2	PS00598
Domain	CHROMO_2	CHD9 CHD7	5.05e-03	28	71	2	PS50013
Domain	CRAL-TRIO_dom	TRIO KALRN	5.05e-03	28	71	2	IPR001251
Domain	SNF2_N	CHD9 CHD7	6.57e-03	32	71	2	IPR000330
Domain	Chromodomain-like	CHD9 CHD7	6.57e-03	32	71	2	IPR016197
Domain	SNF2_N	CHD9 CHD7	6.57e-03	32	71	2	PF00176
Domain	Chromo/shadow_dom	CHD9 CHD7	6.97e-03	33	71	2	IPR000953
Domain	CHROMO	CHD9 CHD7	6.97e-03	33	71	2	SM00298
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	CACNA1C CYP4A11 PLCB3 CYP4A22 ITPR1	5.77e-05	115	51	5	M9387
Pathway	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	ARHGEF40 TRIO KALRN ARHGEF5	5.97e-05	59	51	4	M11215
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	ARHGEF40 TRIO KALRN ARHGEF5	1.61e-04	76	51	4	M19832
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	AGO2 AP2A1 PSMD9 PLCB3 ITPR1	1.78e-04	146	51	5	M27288
Pathway	REACTOME_RHO_GTPASE_CYCLE	RHPN1 DLG5 ARHGEF40 TRIO KALRN ARHGEF5 SPTAN1 CYFIP2	1.93e-04	450	51	8	M27078
Pathway	REACTOME_RHOA_GTPASE_CYCLE	RHPN1 ARHGEF40 TRIO KALRN ARHGEF5	1.96e-04	149	51	5	M41805
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	ARHGEF40 TRIO KALRN ARHGEF5	1.96e-04	80	51	4	M800
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	PIK3CG PLCB3 ITPR1	2.25e-04	33	51	3	M39745
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	ARHGEF40 TRIO KALRN IKBKE ARHGEF5	2.28e-04	154	51	5	M27697
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	BLM AGO2 TRIO SPTAN1 SYNE2 PLCL2 CCDC18 TRIOBP PSTPIP2 LZTS2 CYFIP2 KNL1 ITPR1 NCOA5	4.79e-08	1049	75	14	27880917
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	AGO2 AP2A1 TRIO KALRN SPTAN1 SYNE2 APC TRIOBP MACF1 FYCO1 CHD7 CYFIP2 MPRIP	1.34e-07	963	75	13	28671696
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	KIF20A AGO2 DIS3L SPTAN1 BRPF1 APC TRIOBP MACF1 PSTPIP2 CYFIP2 MPRIP	4.31e-07	724	75	11	36232890
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	DLG5 AGO2 INTS7 SPTAN1 APC TASOR KNL1	9.61e-07	242	75	7	34011540
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	AGO2 AP2A1 TCHP DIS3L CCDC18 CYFIP2	1.84e-06	169	75	6	31462741
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DLG5 CARMIL2 TRIO IKBKE ARHGEF5 SPTAN1 SYNE2 CCDC18 APC MACF1 MPRIP	2.32e-06	861	75	11	36931259
Pubmed	Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice.	APC SMAD4	4.59e-06	2	75	2	11197776
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	4.59e-06	2	75	2	15611369
Pubmed	A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.	APC SMAD4	4.59e-06	2	75	2	19578404
Pubmed	Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.	KIF20A DLG5	4.59e-06	2	75	2	15665285
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	4.59e-06	2	75	2	23825080
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	4.59e-06	2	75	2	16691295
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	4.59e-06	2	75	2	3829886
Pubmed	Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria.	KALRN CHD7	4.59e-06	2	75	2	28152519
Pubmed	A genetic screen for components of the mammalian RNA interference pathway in Bloom-deficient mouse embryonic stem cells.	BLM AGO2	4.59e-06	2	75	2	19223321
Pubmed	Smad4 haploinsufficiency in mouse models for intestinal cancer.	APC SMAD4	4.59e-06	2	75	2	16288217
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	4.59e-06	2	75	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	4.59e-06	2	75	2	21820496
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	4.59e-06	2	75	2	23641057
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	4.59e-06	2	75	2	20943934
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	4.59e-06	2	75	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	4.59e-06	2	75	2	24413902
Pubmed	Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.	APC SMAD4	4.59e-06	2	75	2	10626800
Pubmed	Cancer predisposition caused by elevated mitotic recombination in Bloom mice.	BLM APC	4.59e-06	2	75	2	11101838
Pubmed	APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.	ZBTB2 APC	4.59e-06	2	75	2	39328595
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	4.59e-06	2	75	2	2766933
Pubmed	Enhanced tumor formation in mice heterozygous for Blm mutation.	BLM APC	4.59e-06	2	75	2	12242442
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	4.59e-06	2	75	2	8031839
Pubmed	Targeting IL-23 for the interception of obesity-associated colorectal cancer.	APC IL23A	4.59e-06	2	75	2	37813000
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	4.59e-06	2	75	2	10860550
Pubmed	New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.	TTC17 CCDC157	4.59e-06	2	75	2	31488582
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	4.59e-06	2	75	2	17112342
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	4.59e-06	2	75	2	11320253
Pubmed	Gastro-intestinal tumorigenesis in Smad4 mutant mice.	APC SMAD4	4.59e-06	2	75	2	10708962
Pubmed	Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.	APC SMAD4	4.59e-06	2	75	2	12096346
Pubmed	Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription.	BLM TOP1MT	4.59e-06	2	75	2	23261817
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	4.59e-06	2	75	2	12464262
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	4.59e-06	2	75	2	26858404
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	4.59e-06	2	75	2	30088983
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	4.59e-06	2	75	2	15066132
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	4.59e-06	2	75	2	19208908
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BLM DLG5 TCHP APC MACF1 CHD7 LZTS2 KNL1 MPRIP	4.95e-06	588	75	9	38580884
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	KIF20A DLG5 SPTAN1 TRIOBP MPRIP	5.89e-06	118	75	5	30979931
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	AGO2 TRIO KALRN INTS7 SPTAN1 APC PLCB3 ITPR1	8.65e-06	475	75	8	31040226
Pubmed	Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.	APC SMAD4	1.37e-05	3	75	2	9506519
Pubmed	Phospholipase cbeta is critical for T cell chemotaxis.	PIK3CG PLCB3	1.37e-05	3	75	2	17675482
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	1.37e-05	3	75	2	2354437
Pubmed	SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion.	APC SMAD4	1.37e-05	3	75	2	17369830
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	1.37e-05	3	75	2	31801062
Pubmed	Oncogenic K-Ras suppresses global miRNA function.	AGO2 APC	1.37e-05	3	75	2	37402366
Pubmed	The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.	APC SMAD4	1.37e-05	3	75	2	27750112
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	1.37e-05	3	75	2	8011168
Pubmed	Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas.	APC SMAD4	1.37e-05	3	75	2	19002110
Pubmed	The relative role of PLCbeta and PI3Kgamma in platelet activation.	PIK3CG PLCB3	1.37e-05	3	75	2	15705797
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	1.37e-05	3	75	2	28270609
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	1.37e-05	3	75	2	1991046
Pubmed	Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms.	BLM APC	1.37e-05	3	75	2	15959913
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	1.37e-05	3	75	2	19713718
Pubmed	The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine.	IKBKE APC	1.37e-05	3	75	2	26980769
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	1.37e-05	3	75	2	15313227
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	1.37e-05	3	75	2	37659685
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	1.37e-05	3	75	2	9271096
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	AGO2 CARMIL2 PLCL2 TRIOBP CYFIP2	1.50e-05	143	75	5	32560809
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	TCHP SYNE2 VPS8 CCDC18 TRIOBP LZTS2	1.77e-05	251	75	6	29778605
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	TRIO KALRN SPTAN1 MACF1 CYFIP2 MPRIP	1.77e-05	251	75	6	27507650
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AP2A1 TRIO KALRN DIS3L SPTAN1 APC TRIOBP ZNF624 MACF1 CHD9 TTC17 MPRIP	1.87e-05	1285	75	12	35914814
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	BLM DLG5 AP2A1 KALRN SPTAN1 APC TRIOBP MACF1 CHD9 CHD7 NCOA5	1.99e-05	1082	75	11	38697112
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	ARHGEF40 AGO2 MYH13 AP2A1 TRIO IKBKE LZTS2 CYFIP2 KNL1 MPRIP	2.55e-05	910	75	10	36736316
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KIF20A ZBTB2 ARHGEF40 AGO2 DIS3L BRPF1 MACF1 CHD9 LZTS2 UNC80 KNL1	2.65e-05	1116	75	11	31753913
Pubmed	Effective combinatorial immunotherapy for penile squamous cell carcinoma.	APC SMAD4	2.75e-05	4	75	2	32358507
Pubmed	BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.	APC SMAD4	2.75e-05	4	75	2	28059064
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	2.75e-05	4	75	2	8334987
Pubmed	Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.	PIK3CG PLCB3	2.75e-05	4	75	2	10669417
Pubmed	Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples.	APC SMAD4	2.75e-05	4	75	2	28376920
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 CYP4A22	2.75e-05	4	75	2	1552159
Pubmed	Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.	APC SMAD4	2.75e-05	4	75	2	28759045
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	2.75e-05	4	75	2	10049703
Pubmed	A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment.	APC SMAD4	2.75e-05	4	75	2	31339921
Pubmed	The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.	KIF20A SYNE2	2.75e-05	4	75	2	33686165
Pubmed	Roles of tumor suppressors in regulating tumor-associated inflammation.	APC SMAD4	2.75e-05	4	75	2	25190145
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	2.75e-05	4	75	2	22159897
Pubmed	Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase.	PIK3CG APC	2.75e-05	4	75	2	19525225
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	2.75e-05	4	75	2	21161333
Pubmed	A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.	PIK3CG PLCB3	2.75e-05	4	75	2	22172670
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	AP2A1 TRIO KALRN SPTAN1 MACF1 CYFIP2	3.33e-05	281	75	6	28706196
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNE2 CHD9 CYFIP2 MPRIP	3.88e-05	87	75	4	12465718
Pubmed	Functional proteomics mapping of a human signaling pathway.	EVC2 AP2A1 VPS8 PLCL2 MACF1 LZTS2 SMAD4 KNL1	4.12e-05	591	75	8	15231748
Pubmed	The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.	ZMIZ1 SMAD4	4.57e-05	5	75	2	16777850
Pubmed	Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.	APC MACF1	4.57e-05	5	75	2	17113391
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	TRIO KALRN	4.57e-05	5	75	2	18936096
Pubmed	Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.	CYP4A11 CYP4A22	4.57e-05	5	75	2	8363569
Pubmed	TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.	APC SMAD4	4.57e-05	5	75	2	28622298
Pubmed	Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.	APC SMAD4	4.57e-05	5	75	2	19527492
Pubmed	Distinct roles for CARMIL isoforms in cell migration.	CARMIL2 TRIO	4.57e-05	5	75	2	19846667
Pubmed	Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	4.57e-05	5	75	2	20427718
Pubmed	Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.	CYP4A11 CYP4A22	4.57e-05	5	75	2	7601480
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	AP2A1 TCHP SPTAN1 APC PSMD9 LZTS2 CYFIP2	5.10e-05	446	75	7	24255178
Pubmed	Organization of the distal end of mouse chromosome 4.	CYP4A11 CYP4A22	6.84e-05	6	75	2	3166417
Pubmed	Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.	APC SMAD4	6.84e-05	6	75	2	27708166
Pubmed	Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.	CYP4A11 CYP4A22	6.84e-05	6	75	2	28007964
Interaction	SYNPO interactions	KIF20A AP2A1 KALRN SPTAN1 APC LZTS2 MPRIP ITPR1	5.74e-07	192	75	8	int:SYNPO
Interaction	EZR interactions	DLG5 MYH13 AP2A1 SPTAN1 CCDC18 APC TRIOBP MACF1 PLCB3 JMY CYFIP2 MPRIP	8.76e-07	553	75	12	int:EZR
Interaction	CYFIP2 interactions	AGO2 CARMIL2 AP2A1 SPTAN1 PLCL2 TRIOBP FYCO1 CYFIP2 SMAD4	3.10e-06	323	75	9	int:CYFIP2
Interaction	CEP135 interactions	KIF20A DLG5 AGO2 TCHP CCDC18 APC LZTS2 NCOA5	7.67e-06	272	75	8	int:CEP135
Interaction	AGAP2 interactions	AP2A1 TRIO KALRN SPTAN1 MACF1 CYFIP2 MPRIP	1.31e-05	210	75	7	int:AGAP2
Interaction	MUC17 interactions	KIF20A MUC17	1.37e-05	2	75	2	int:MUC17
Interaction	PARD3 interactions	KIF20A DLG5 TRIO TCHP APC PLCB3 LZTS2 SMAD4	1.49e-05	298	75	8	int:PARD3
Interaction	SASS6 interactions	DLG5 TCHP CCDC18 APC FYCO1 LZTS2	2.82e-05	159	75	6	int:SASS6
Interaction	TMOD1 interactions	DLG5 SPTAN1 CCDC18 APC MACF1 MPRIP	3.02e-05	161	75	6	int:TMOD1
Interaction	CAPZA2 interactions	KIF20A NEU2 CARMIL2 AP2A1 SPTAN1 TRIOBP MACF1 MPRIP ITPR1	3.05e-05	430	75	9	int:CAPZA2
Interaction	SYNE3 interactions	DLG5 AGO2 TCHP SYNE2 CCDC18 APC MACF1 TTC17 LZTS2	3.91e-05	444	75	9	int:SYNE3
Interaction	CYP4A22 interactions	CYP4A11 CYP4A22	4.09e-05	3	75	2	int:CYP4A22
Interaction	DSCAM interactions	AGO2 AP2A1 KALRN MACF1 TTC17 MPRIP	4.24e-05	171	75	6	int:DSCAM
Interaction	PEX5L interactions	AGO2 AP2A1 SPTAN1 CYFIP2	4.86e-05	54	75	4	int:PEX5L
Interaction	FBXO42 interactions	DLG5 TCHP APC MACF1 CHD7 KNL1 MPRIP	5.03e-05	259	75	7	int:FBXO42
Interaction	CEP63 interactions	TCHP SPTAN1 BRPF1 CCDC18 MACF1 LZTS2	5.47e-05	179	75	6	int:CEP63
Interaction	DLGAP1 interactions	TRIO KALRN SPTAN1 APC CYFIP2 MPRIP	5.64e-05	180	75	6	int:DLGAP1
Interaction	GOLGA1 interactions	DLG5 TCHP CCDC18 APC MACF1 JMY	6.19e-05	183	75	6	int:GOLGA1
Interaction	PPP1R12C interactions	KIF20A MACF1 CYFIP2 MPRIP	6.45e-05	58	75	4	int:PPP1R12C
Interaction	LYN interactions	KIF20A DLG5 TRIO PIK3CG ARHGEF5 SPTAN1 APC MACF1 LZTS2 CYFIP2 ITPR1	6.84e-05	720	75	11	int:LYN
Interaction	TNRC6A interactions	KIF20A DLG5 AGO2 AP2A1 TCHP TRIM65 LZTS2	8.22e-05	280	75	7	int:TNRC6A
Interaction	TNIK interactions	AP2A1 TRIO KALRN SPTAN1 SYNE2 APC MACF1 CYFIP2	8.48e-05	381	75	8	int:TNIK
Interaction	SPC25 interactions	AP2A1 PSMD9 PLCB3 KNL1	9.49e-05	64	75	4	int:SPC25
Interaction	MIB1 interactions	BLM AGO2 AP2A1 TCHP DIS3L CCDC18 CYFIP2	1.14e-04	295	75	7	int:MIB1
Interaction	MYO18A interactions	KIF20A AP2A1 SPTAN1 TRIOBP LZTS2 SMAD4 MPRIP	1.34e-04	303	75	7	int:MYO18A
Interaction	CYP4A11 interactions	CYP4A11 CYP4A22	1.36e-04	5	75	2	int:CYP4A11
Interaction	TNRC6C interactions	AGO2 AP2A1 TCHP CCDC18 LZTS2	1.64e-04	138	75	5	int:TNRC6C
Interaction	SPTBN1 interactions	KIF20A KALRN SPTAN1 SYNE2 APC CYFIP2 CFAP46 SMAD4	1.69e-04	421	75	8	int:SPTBN1
Interaction	EPB41L4A interactions	DLG5 SPTAN1 APC MACF1 LZTS2	1.76e-04	140	75	5	int:EPB41L4A
Interaction	YWHAH interactions	DLG5 EVC2 CARMIL2 TRIO IKBKE ARHGEF5 SPTAN1 SYNE2 CCDC18 APC MACF1 CYFIP2 MPRIP	1.95e-04	1102	75	13	int:YWHAH
Interaction	DSCR9 interactions	TRIO KALRN DIS3L TRIOBP MACF1	2.21e-04	147	75	5	int:DSCR9
Interaction	TBKBP1 interactions	KIF20A AGO2 IKBKE LZTS2	2.26e-04	80	75	4	int:TBKBP1
Interaction	GJA1 interactions	DLG5 TRIO KALRN SPTAN1 SYNE2 APC MACF1 LZTS2 CYFIP2	3.06e-04	583	75	9	int:GJA1
Interaction	LCK interactions	DLG5 AP2A1 TRIO KALRN SPTAN1 MACF1 LZTS2 MPRIP	3.20e-04	463	75	8	int:LCK
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF40 TRIO KALRN ARHGEF5	3.29e-05	66	50	4	722
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCL2 PLCB3	1.24e-03	19	50	2	832
Coexpression	GEORGES_TARGETS_OF_MIR192_AND_MIR215	KIF20A BLM DLG5 CCDC121 AGO2 TCHP DIS3L CCDC18 APC MACF1 CHD7 KNL1	8.15e-06	892	75	12	M18120
Coexpression	GSE6875_WT_VS_FOXP3_KO_TREG_UP	ZBTB2 PIK3CG SPTAN1 VPS8 PLCL2 AMZ2	2.38e-05	200	75	6	M6803
Coexpression	RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN	IVD EVA1C ARHGEF40 SYNE2 FYCO1 ZMIZ1 CYFIP2 SMAD4 ITPR1	2.42e-05	542	75	9	M19529
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	BLM AGO2 TRIO SYNE2 APC MACF1 CHD9 ZMIZ1 TASOR SMAD4 ITPR1	3.08e-05	856	75	11	M4500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	ZBTB2 TRIO APC ZNF624 MACF1 CHD9 CHD7 TASOR KNL1 MPRIP	2.52e-05	564	74	10	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	ZBTB2 TRIO SYNE2 APC MACF1 CHD9 CHD7 TASOR CYFIP2 MPRIP	3.96e-05	595	74	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#4	SYNE2 ZNF624 MACF1 CHD9 CHD7 MPRIP	7.65e-05	203	74	6	Facebase_RNAseq_e9.5_Mandibular Arch_1000_K4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HK3 KALRN THAP8 PLCB3 LZTS2	2.74e-06	130	75	5	92913960e4367261ba08a405b61a421bc5e18169
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	KIF20A CACNA1C CCDC18 LZTS2 KNL1	1.04e-05	171	75	5	0eea035fde32cc2a75a0d4227911edb5d54ed47e
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CACNA1C CCDC18 TRIM65 LZTS2 KNL1	1.16e-05	175	75	5	bde785ff0c854646d7ab8571359e9d69a7bf013f
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KALRN PIK3CG PSTPIP2 JMY ABHD16A	1.30e-05	179	75	5	906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ZBTB2 SYNE2 VPS8 CYFIP2 MPRIP	1.30e-05	179	75	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF20A BLM PIPOX IL23A KNL1	1.37e-05	181	75	5	73b1b59810f60e3e39ca1d5073a5a0d4f5377e6e
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AGO2 CARMIL2 SPTAN1 SYNE2 MPRIP	1.41e-05	182	75	5	b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	AGO2 CARMIL2 SPTAN1 SYNE2 MPRIP	1.41e-05	182	75	5	1aea96ee211f7b9caef7fd385233f51be6021a73
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AGO2 CARMIL2 SPTAN1 SYNE2 MPRIP	1.41e-05	182	75	5	c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AGO2 CARMIL2 SPTAN1 SYNE2 MPRIP	1.41e-05	182	75	5	4cb182ef39be2044a6ad7266f332d4177591e550
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SPTAN1 SYNE2 MACF1 CYFIP2 MPRIP	1.96e-05	195	75	5	4bdedd924564a260841a9153604026b57487c83d
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SPTAN1 SYNE2 MACF1 CYFIP2 MPRIP	2.06e-05	197	75	5	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C KALRN SPTAN1 UNC80 ITPR1	2.11e-05	198	75	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TRIO SPTAN1 SYNE2 MACF1 CHD7	2.21e-05	200	75	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Non-neuronal-Dividing-IPC\|World / Primary Cells by Cluster	KIF20A SYNE2 CCDC18 CHD7 KNL1	2.21e-05	200	75	5	971533181daa1bfac1f1b8c507d2013f891f9078
Disease	neuroblastoma	EVA1C ARHGEF40 MYH13 TRIO KALRN	1.12e-05	116	74	5	EFO_0000621
Disease	Pancreatic carcinoma	TCHP APC SMAD4	1.43e-05	19	74	3	C0235974
Disease	Immunologic Deficiency Syndromes	BLM CACNA1C CHD7	2.59e-05	23	74	3	C0021051
Disease	X-14939 measurement	CYP4A11 CYP4A22	9.25e-05	6	74	2	EFO_0800747
Disease	serum gamma-glutamyl transferase measurement	EVA1C DLG5 KALRN TRIOBP CHD9 ZMIZ1 LZTS2 CYFIP2 MPRIP ITPR1	9.25e-05	914	74	10	EFO_0004532
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD7	1.29e-04	7	74	2	DOID:0050834 (implicated_via_orthology)
Disease	marginal zone B-cell lymphoma, multiple sclerosis	ZMIZ1 NCOA5	2.21e-04	9	74	2	EFO_1000630, MONDO_0005301
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	3.36e-04	11	74	2	DOID:0110861 (biomarker_via_orthology)
Disease	Colorectal Carcinoma	EVC2 HK3 KALRN APC ZNF624 ZMIZ1 LZTS2 SMAD4	3.73e-04	702	74	8	C0009402
Disease	endometrial carcinoma (is_implicated_in)	APC SMAD4	4.03e-04	12	74	2	DOID:2871 (is_implicated_in)
Disease	Benign tumor of pancreas	APC SMAD4	4.75e-04	13	74	2	C0347284
Disease	psoriasis	IKBKE SYNE2 PLCL2 TRIM65 ZMIZ1	6.25e-04	273	74	5	EFO_0000676
Disease	congenital heart disease (implicated_via_orthology)	CHD9 CHD7 ITPR1	7.04e-04	69	74	3	DOID:1682 (implicated_via_orthology)
Disease	hematocrit	CACNA1C ARHGEF40 KALRN PLCL2 PLCB3 TASOR CCDC157 MPRIP ITPR1	9.43e-04	1011	74	9	EFO_0004348
Disease	Stomach Carcinoma	TCHP APC	1.26e-03	21	74	2	C0699791
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	SYNE2 MACF1 PLCB3	2.24e-03	103	74	3	EFO_0008595, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLSNLHVQQQEQRQC	ARHGEF40	771	Q8TER5
HVQQQEQRQCLRRLQ	ARHGEF40	776	Q8TER5
CQARCQELERRIQQH	ARHGEF40	941	Q8TER5
AVHQIQACLLRNNRA	CARMIL2	691	Q6F5E8
HALEQLIRDCNNNVQ	ARHGEF5	1346	Q12774
RTVRQHLNLNNAEQL	ABHD16A	401	O95870
CNQLGQFLQHRETNL	AP2A1	331	O95782
LLQLQHQLRCQDRTT	CFAP46	2116	Q8IYW2
CQLAHQHTDQVIQLR	CYP4A11	256	Q02928
RCSFRVNENTHNLQI	AMZ2	136	Q86W34
HMQQCLQERVQNCDR	DNHD1	471	Q96M86
CRHQENLIENLARQR	DNHD1	3196	Q96M86
IQARQRLQGSHNQCL	CCDC121	241	Q6ZUS5
RLQGSHNQCLNRQDV	CCDC121	246	Q6ZUS5
LQSEREQGQCQLRAQ	CCDC157	486	Q569K6
QNDLQAQARCHRIGQ	CHD7	1391	Q9P2D1
CATVRVQQHRQEIIQ	AGO2	626	Q9UKV8
NVAQCHIQLAQSLRE	PSTPIP2	86	Q9H939
RNVELQQQSCLLISH	INTS7	701	Q9NVH2
CQRENQELNAHNQEL	MPRIP	851	Q6WCQ1
CAAQAQRAQRAQQLL	LZTS2	376	Q9BRK4
QDLRAVHQQLCSVNS	JMY	236	Q8N9B5
QQNAHTSRMLQVCQR	GPR179	1156	Q6PRD1
ENHNRDLQNFLRCQN	ITPR1	1986	Q14643
RHRELRALESQCQQQ	FYCO1	726	Q9BQS8
RDQVHEDRSIQQIQC	IKBKE	531	Q14164
QLQLQAAHAQEQIRR	CSN1S1	111	P47710
ITQQHQIHRSCTVNI	NCOA5	256	Q9HCD5
RLHQRLQLCVFQQDV	KALRN	531	O60229
TQQRDTAIQLQHQCA	DLG5	356	Q8TDM6
SQTLLEQHQQCLREE	EVC2	1081	Q86UK5
AQVESCQLNNRDRRN	KNL1	1296	Q8NG31
NHNRITQCLHQQLEV	CYFIP2	216	Q96F07
AHSNLCINQLVRNGN	IVD	131	P26440
QACRTILQQQQRHQE	FOXD4	356	Q12950
ILQQQQRHQEEDCAN	FOXD4	361	Q12950
VLSCLQHSREQQTLQ	HK3	406	P52790
ALDLCQHQDRVQNLR	MACF1	4291	Q9UPN3
TNNQLINCRNHILEF	MGAT4D	31	A6NG13
EQQQLQTRANVTRLC	NEU2	111	Q9Y3R4
RHDRLVAGQQQVLQQ	PLCB3	1146	Q01970
QNQRACHLLVNSRVF	EVA1C	126	P58658
NPQNDLQAQARCHRI	CHD9	1281	Q3L8U1
CDARQISLQQQLIHV	BLM	361	P54132
NNRFRLQCHRIVNDT	CACNA1C	886	Q13936
RLHCQVNKLQSNRRQ	CCDC122	236	Q5T0U0
NKLRQQNACLVTQNH	CCDC18	121	Q5T9S5
LCRHINNRNQAAQHS	DIS3L	836	Q8TF46
CQLAHQHTDQVIQLR	CYP4A22	256	Q5TCH4
GLRDNSQFCLQRIHQ	IL23A	81	Q9NPF7
DVLNRQCQQLSQHVR	MUC17	46	Q685J3
QVRTARHNIICLQND	PSMD9	71	O00233
RLQRCQERHQAQLQA	THAP8	186	Q8NA92
RIQRFIQNTCNEVEH	SYNE2	2926	Q8WXH0
HITLCNAVQCIRNLN	PLCL2	286	Q9UPR0
RQCHRQMQQQAATAQ	SMAD4	441	Q13485
VETIALCQRNSHNLN	VPS8	1121	Q8N3P4
LCQRNSHNLNQQQRE	VPS8	1126	Q8N3P4
TQIQCGQLQSRRAQI	RHPN1	26	Q8TCX5
RRCQQEGQELLRHNQ	TRIOBP	2231	Q9H2D6
CLIRLQAQNIQQRHI	TASOR	1421	Q9UK61
QTHLQSQRNCDQVGR	BRPF1	561	P55201
DHRQILRENNCLQTL	APC	651	P25054
NIQHGQQVLCQRRTS	PIK3CG	386	P48736
QQSRRQCHAEEDQSQ	SMIM2	66	Q9BVW6
QCARLNQHQRIQTGE	ZNF624	371	Q9P2J8
RRHQNVVQFEECVLQ	STK35	256	Q8TDR2
DRLRHQVFRENAQNC	UNC80	816	Q8N2C7
TLGRCIAALRQNQQN	KIF20A	436	O95235
IQALREQAQSCRQQV	SPTAN1	946	Q13813
NRANRVVAILCNHQR	TOP1MT	456	Q969P6
EQANTQLSRCRRVQH	MYH13	1891	Q9UKX3
CSQQRLNQQLARQRE	TCHP	11	Q9BT92
AAQIEQLRRNHNQAI	TTC23L	261	Q6PF05
LGNHQICRLVNQQHS	TTC17	406	Q96AE7
IQANLSRQRVEHQCL	PIPOX	106	Q9P0Z9
RANQAARHVCLNQSI	ZBTB2	401	Q8N680
VQQCNGQNTLRNIVH	ZNF614	101	Q8N883
LSRQDQQVKHCRQSR	TRIM65	346	Q6PJ69
RLHQRLQLCVFQQDV	TRIO	561	O75962
RHIQQTNDRLQCIKQ	ZMIZ1	6	Q9ULJ6