Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nitric-oxide synthase binding	DNM3 DNM1 DNM2	5.64e-06	22	32	3	GO:0050998
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	DNM3 DNM1 DNM2	7.40e-06	24	32	3	GO:0120283
GeneOntologyMolecularFunction	D2 dopamine receptor binding	DNM1 DNM2	5.20e-05	7	32	2	GO:0031749
GeneOntologyMolecularFunction	glycosyltransferase activity	PYGL GLT6D1 POMT1 UGT1A7 SIRT1	8.82e-05	288	32	5	GO:0016757
GeneOntologyMolecularFunction	hexosyltransferase activity	PYGL GLT6D1 POMT1 UGT1A7	3.46e-04	211	32	4	GO:0016758
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	OBSCN DNM1 DNM2	4.68e-04	95	32	3	GO:0005546
GeneOntologyMolecularFunction	dopamine receptor binding	DNM1 DNM2	7.89e-04	26	32	2	GO:0050780
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate binding	OBSCN DNM1 DNM2	9.47e-04	121	32	3	GO:1902936
GeneOntologyMolecularFunction	structural constituent of muscle	OBSCN MYBPC2	2.16e-03	43	32	2	GO:0008307
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	OBSCN DNM1	2.79e-03	49	32	2	GO:0005547
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	OBSCN DNM1 DNM2	3.91e-03	199	32	3	GO:1901981
GeneOntologyBiologicalProcess	synaptic vesicle budding from presynaptic endocytic zone membrane	DNM3 DNM1 DNM2	5.55e-07	11	32	3	GO:0016185
GeneOntologyBiologicalProcess	synaptic vesicle budding	DNM3 DNM1 DNM2	1.52e-06	15	32	3	GO:0070142
GeneOntologyBiologicalProcess	vesicle scission	DNM1 DNM2	6.99e-06	3	32	2	GO:0099050
GeneOntologyBiologicalProcess	synaptic vesicle transport	DNM3 DNM1 DNM2	7.97e-05	54	32	3	GO:0048489
GeneOntologyBiologicalProcess	synaptic vesicle localization	DNM3 DNM1 DNM2	1.80e-04	71	32	3	GO:0097479
GeneOntologyCellularComponent	photoreceptor inner segment	DNM3 DNM1 DNM2	2.29e-04	78	32	3	GO:0001917
GeneOntologyCellularComponent	myosin filament	OBSCN MYBPC2	6.66e-04	25	32	2	GO:0032982
GeneOntologyCellularComponent	M band	OBSCN MYBPC2	1.03e-03	31	32	2	GO:0031430
GeneOntologyCellularComponent	microtubule	DNAH2 DNM3 TTLL10 DNM1 DNM2	1.20e-03	533	32	5	GO:0005874
GeneOntologyCellularComponent	supramolecular fiber	DNAH2 OBSCN DNM3 TTLL10 DNM1 DNM2 MYBPC2	1.73e-03	1179	32	7	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	DNAH2 OBSCN DNM3 TTLL10 DNM1 DNM2 MYBPC2	1.80e-03	1187	32	7	GO:0099081
Domain	Dynamin_central	DNM3 DNM1 DNM2	9.11e-08	6	32	3	IPR000375
Domain	Dynamin_M	DNM3 DNM1 DNM2	9.11e-08	6	32	3	PF01031
Domain	Dynamin_GTPase_CS	DNM3 DNM1 DNM2	9.11e-08	6	32	3	IPR019762
Domain	GED	DNM3 DNM1 DNM2	9.11e-08	6	32	3	SM00302
Domain	GED_dom	DNM3 DNM1 DNM2	9.11e-08	6	32	3	IPR020850
Domain	GED	DNM3 DNM1 DNM2	9.11e-08	6	32	3	PF02212
Domain	GED	DNM3 DNM1 DNM2	9.11e-08	6	32	3	IPR003130
Domain	GED	DNM3 DNM1 DNM2	9.11e-08	6	32	3	PS51388
Domain	G_DYNAMIN_1	DNM3 DNM1 DNM2	1.59e-07	7	32	3	PS00410
Domain	DYNc	DNM3 DNM1 DNM2	1.59e-07	7	32	3	SM00053
Domain	G_DYNAMIN_dom	DNM3 DNM1 DNM2	1.64e-06	14	32	3	IPR030381
Domain	G_DYNAMIN_2	DNM3 DNM1 DNM2	1.64e-06	14	32	3	PS51718
Domain	Dynamin_SF	DNM3 DNM1 DNM2	2.05e-06	15	32	3	IPR022812
Domain	Dynamin_GTPase	DNM3 DNM1 DNM2	2.05e-06	15	32	3	IPR001401
Domain	Dynamin_N	DNM3 DNM1 DNM2	2.05e-06	15	32	3	PF00350
Domain	PH	OBSCN DNM3 MCF2 DNM1 DNM2	4.08e-05	229	32	5	PF00169
Domain	PH	OBSCN DNM3 MCF2 DNM1 DNM2	1.02e-04	278	32	5	SM00233
Domain	PH_DOMAIN	OBSCN DNM3 MCF2 DNM1 DNM2	1.04e-04	279	32	5	PS50003
Domain	PH_domain	OBSCN DNM3 MCF2 DNM1 DNM2	1.06e-04	280	32	5	IPR001849
Domain	-	OBSCN DNM3 MCF2 DNM1 DNM2	4.95e-04	391	32	5	2.30.29.30
Domain	PH_dom-like	OBSCN DNM3 MCF2 DNM1 DNM2	7.31e-04	426	32	5	IPR011993
Domain	GDS_CDC24_CS	OBSCN MCF2	2.03e-03	39	32	2	IPR001331
Domain	DH_1	OBSCN MCF2	5.20e-03	63	32	2	PS00741
Domain	RhoGEF	OBSCN MCF2	6.04e-03	68	32	2	SM00325
Domain	DH_2	OBSCN MCF2	6.39e-03	70	32	2	PS50010
Domain	RhoGEF	OBSCN MCF2	6.39e-03	70	32	2	PF00621
Domain	DH-domain	OBSCN MCF2	6.57e-03	71	32	2	IPR000219
Domain	-	OBSCN MCF2	6.57e-03	71	32	2	1.20.900.10
Domain	Kinase-like_dom	OBSCN DNM3 DNM1 DNM2	1.32e-02	542	32	4	IPR011009
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	DNM3 DNM1 DNM2	1.77e-06	14	25	3	M10122
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	DNM3 DNM1 DNM2	3.68e-05	37	25	3	MM15102
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	DNM3 DNM1 DNM2	8.60e-05	49	25	3	M891
Pathway	WP_SYNAPTIC_VESICLE_PATHWAY	DNM3 DNM1 DNM2	9.70e-05	51	25	3	M39457
Pathway	REACTOME_GAP_JUNCTION_DEGRADATION	DNM1 DNM2	1.64e-04	11	25	2	MM14732
Pathway	REACTOME_GAP_JUNCTION_DEGRADATION	DNM1 DNM2	1.97e-04	12	25	2	M15243
Pathway	REACTOME_L1CAM_INTERACTIONS	DNM3 DNM1 DNM2	2.29e-04	68	25	3	MM14968
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	DNM3 DNM1 DNM2	6.31e-04	96	25	3	M16121
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	DNM3 NTN4 DNM1 DNM2	1.07e-03	261	25	4	MM15676
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	DNM3 DNM1 DNM2	1.09e-03	116	25	3	MM14855
Pathway	REACTOME_L1CAM_INTERACTIONS	DNM3 DNM1 DNM2	1.24e-03	121	25	3	M872
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE	DNM3 DNM1 DNM2	1.27e-03	122	25	3	MM14640
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	DNM3 DNM1 DNM2	1.39e-03	126	25	3	M705
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	DNM3 NTN4 DNM1 SIRT1 DNM2	1.65e-03	502	25	5	MM14537
Pathway	REACTOME_SIGNALING_BY_NTRKS	DNM3 DNM1 DNM2	1.66e-03	134	25	3	M3574
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	DNM3 DNM1 DNM2	1.96e-03	142	25	3	MM15499
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	DNM3 DNM1 DNM2	2.08e-03	145	25	3	M27753
Pubmed	Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.	DNM3 DNM1 DNM2	7.07e-10	3	32	3	28395327
Pubmed	Dynamin and endocytosis.	DNM3 DNM1 DNM2	7.07e-10	3	32	3	12383797
Pubmed	Dynamin at the actin-membrane interface.	DNM3 DNM1 DNM2	7.07e-10	3	32	3	12517701
Pubmed	Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.	DNM3 DNM1 DNM2	7.07e-10	3	32	3	24046449
Pubmed	Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.	DNM3 DNM1 DNM2	7.07e-10	3	32	3	24273169
Pubmed	Dynamin: characteristics, mechanism of action and function.	DNM3 DNM1 DNM2	7.07e-10	3	32	3	12511974
Pubmed	Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.	DNM3 DNM1 DNM2	2.83e-09	4	32	3	21689597
Pubmed	Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.	DNM3 DNM1 DNM2	2.83e-09	4	32	3	22846998
Pubmed	Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.	DNM3 DNM1 DNM2	7.07e-09	5	32	3	9722593
Pubmed	Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.	DNM3 DNM1 DNM2	1.41e-08	6	32	3	23640057
Pubmed	Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo.	DNM3 DNM1 DNM2	1.41e-08	6	32	3	27251629
Pubmed	A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.	DNM3 DNM1 DNM2	1.41e-08	6	32	3	18602423
Pubmed	A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.	DNM3 DNM1 DNM2	2.47e-08	7	32	3	15252009
Pubmed	Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.	DNM3 DNM1 DNM2	3.95e-08	8	32	3	24282027
Pubmed	Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.	DNM3 DNM1 DNM2	5.92e-08	9	32	3	23170932
Pubmed	Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation.	DNM3 DNM1 DNM2	8.45e-08	10	32	3	10398046
Pubmed	Protein partners of dynamin-1 in the retina.	DNM3 DNM1 DNM2	8.45e-08	10	32	3	23746204
Pubmed	Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.	DNM3 DNM1 DNM2	2.56e-07	14	32	3	20802490
Pubmed	EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.	DNM3 DNM1 DNM2	4.77e-07	17	32	3	37042948
Pubmed	The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.	DNM3 DNM1	8.20e-07	2	32	2	38641407
Pubmed	Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.	DNM1 DNM2	8.20e-07	2	32	2	25116793
Pubmed	Dynamin regulates L cell secretion in human gut.	DNM1 DNM2	8.20e-07	2	32	2	34274446
Pubmed	Dynamin at actin tails.	DNM1 DNM2	8.20e-07	2	32	2	11782545
Pubmed	A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.	DNM3 DNM1	8.20e-07	2	32	2	24963135
Pubmed	Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.	DNM3 DNM1	8.20e-07	2	32	2	24673776
Pubmed	Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.	DNM1 DNM2	8.20e-07	2	32	2	21670293
Pubmed	Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study.	DNM1 DNM2	8.20e-07	2	32	2	16028072
Pubmed	Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.	DNM1 DNM2	8.20e-07	2	32	2	22977254
Pubmed	Crystal structure of the dynamin tetramer.	DNM3 DNM1	8.20e-07	2	32	2	26302298
Pubmed	Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.	DNM3 DNM1	8.20e-07	2	32	2	22308498
Pubmed	Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility.	DNM1 DNM2	8.20e-07	2	32	2	32065700
Pubmed	An intramolecular signaling element that modulates dynamin function in vitro and in vivo.	DNM1 DNM2	8.20e-07	2	32	2	19515832
Pubmed	Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.	DNM3 DNM1	8.20e-07	2	32	2	20700106
Pubmed	Dynamin is primed at endocytic sites for ultrafast endocytosis.	DNM3 DNM1	8.20e-07	2	32	2	35809574
Pubmed	Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.	DNM3 DNM1 DNM2	2.04e-06	27	32	3	19723784
Pubmed	Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9.	DNM3 DNM1	2.46e-06	3	32	2	35065714
Pubmed	SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.	DNM1 DNM2	2.46e-06	3	32	2	15703209
Pubmed	Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.	DNM1 DNM2	2.46e-06	3	32	2	22371560
Pubmed	Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.	DNM1 DNM2	2.46e-06	3	32	2	24145164
Pubmed	The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.	DNM3 DNM2	2.46e-06	3	32	2	32573516
Pubmed	The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.	DNM1 DNM2	2.46e-06	3	32	2	11483962
Pubmed	Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.	DNM1 DNM2	2.46e-06	3	32	2	15895076
Pubmed	Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits.	DNM1 DNM2	4.92e-06	4	32	2	20059951
Pubmed	Dynamin2 and cortactin regulate actin assembly and filament organization.	DNM1 DNM2	4.92e-06	4	32	2	12419186
Pubmed	Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors.	DNM1 DNM2	4.92e-06	4	32	2	14709338
Pubmed	Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling.	DNM3 DNM1	4.92e-06	4	32	2	28621662
Pubmed	Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts.	DNM1 DNM2	4.92e-06	4	32	2	25287300
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	DNM3 DNM2 DNMT3A	7.93e-06	42	32	3	14760703
Pubmed	Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.	DNM1 DNM2	8.19e-06	5	32	2	21169560
Pubmed	Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts.	DNM1 DNM2	8.19e-06	5	32	2	19380485
Pubmed	Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.	DNM1 DNM2	1.23e-05	6	32	2	24970086
Pubmed	Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.	DNM1 DNM2	1.23e-05	6	32	2	23187129
Pubmed	TTP specifically regulates the internalization of the transferrin receptor.	DNM1 DNM2	1.23e-05	6	32	2	16325581
Pubmed	Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model.	DNM1 DNM2	1.23e-05	6	32	2	31570755
Pubmed	The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.	DNM1 DNM2	1.72e-05	7	32	2	10542231
Pubmed	A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.	DNM1 DNM2	1.72e-05	7	32	2	18353773
Pubmed	Neurons limit angiogenesis by titrating VEGF in retina.	DNM1 DNM2	2.29e-05	8	32	2	25417109
Pubmed	Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.	DNM1 DNM2	2.29e-05	8	32	2	22099461
Pubmed	Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation.	DNM1 DNM2	2.29e-05	8	32	2	15834155
Pubmed	Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively.	DNM1 DNM2	2.94e-05	9	32	2	9143510
Pubmed	Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.	DNM1 DNM2	4.49e-05	11	32	2	12456676
Pubmed	Redundant and nonredundant organismal functions of EPS15 and EPS15L1.	DNM1 DNM2	7.41e-05	14	32	2	30692166
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	DNM3 DNM1 DNM2	1.18e-04	103	32	3	21706016
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A7 PYROXD2	1.39e-04	19	32	2	23281178
Pubmed	Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.	CYP8B1 SIRT1	1.87e-04	22	32	2	27146480
Pubmed	Genetic variation in healthy oldest-old.	SIRT1 DNMT3A	2.24e-04	24	32	2	19680556
Pubmed	Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.	DNM3 DNM2 DNMT3A	2.67e-04	136	32	3	25429064
Pubmed	The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation.	DNM1 DNM2	3.05e-04	28	32	2	24448406
Pubmed	Many sequence variants affecting diversity of adult human height.	DNM3 PDE3A DNMT3A	3.09e-04	143	32	3	18391951
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	OBSCN MCF2	5.65e-04	38	32	2	11756498
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	OBSCN MCF2	7.23e-04	43	32	2	12376548
Interaction	ZBBX interactions	DNM3 DNM1 DNM2	1.59e-05	31	32	3	int:ZBBX
Interaction	LYPD6 interactions	DNM3 DNM1 DNM2	1.92e-05	33	32	3	int:LYPD6
Interaction	DNMBP interactions	DNM3 DNM1 VPS33B DNM2	4.30e-05	124	32	4	int:DNMBP
Interaction	FER interactions	DNM3 DNM1 DNM2	6.77e-05	50	32	3	int:FER
Interaction	RPE interactions	DNM3 DNM1 DNM2	1.06e-04	58	32	3	int:RPE
Interaction	SNX33 interactions	DNM3 DNM1 DNM2	1.42e-04	64	32	3	int:SNX33
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	GLT6D1 POMT1 DNM1	1.50e-03	325	32	3	chr9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr14q22	PYGL ABHD12B	1.98e-03	94	32	2	chr14q22
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DNM3 DNM1 DNM2	3.49e-03	206	27	3	682
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN MCF2	4.34e-03	66	27	2	722
GeneFamily	Fibronectin type III domain containing	OBSCN MYBPC2	2.36e-02	160	27	2	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSCN MYBPC2	2.39e-02	161	27	2	593
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PYGL FRY PDE3A DNM1	1.24e-05	200	32	4	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PYGL FRY PDE3A DNM1	1.24e-05	200	32	4	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM50B DNM3 IKZF2	1.74e-04	152	32	3	eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NTN4 DNM1 MYBPC2	1.92e-04	157	32	3	a93866f051472506f1468f379c0d5313e02c9731
ToppCell	droplet-Thymus-nan-21m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN MCF2 CYP8B1	2.07e-04	161	32	3	441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 FRY PDE3A	2.07e-04	161	32	3	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 PYGL PDE3A	2.18e-04	164	32	3	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 EFCAB3 TTLL10	2.34e-04	168	32	3	ce9fae8b295c668b0959d5007a8bcd401d80e258
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	2.43e-04	170	32	3	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 FRY PDE3A	2.43e-04	170	32	3	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 FRY PDE3A	2.43e-04	170	32	3	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 FRY PDE3A	2.43e-04	170	32	3	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNM3 EFCAB3 TTLL10	2.47e-04	171	32	3	584a095ddcbf78aa29527f84b46b5ad3e2edbaa9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 PYGL PDE3A	2.51e-04	172	32	3	553701349444eb366df3c11f54bb093434f153c6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 PYGL PDE3A	2.51e-04	172	32	3	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NTN4 FRY PDE3A	2.60e-04	174	32	3	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	2.69e-04	176	32	3	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 EFCAB3 TTLL10	2.78e-04	178	32	3	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FRY IKZF2 MYBPC2	2.78e-04	178	32	3	71ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	FRY PDE3A DNM1	2.82e-04	179	32	3	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	PDE3A IKZF2 ABHD12B	2.87e-04	180	32	3	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	2.91e-04	181	32	3	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	3'_v3-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	PDE3A IKZF2 ABHD12B	2.91e-04	181	32	3	30ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	2.96e-04	182	32	3	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABHD12B KCND1 PYROXD2	2.96e-04	182	32	3	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3A DNM1 ABHD12B	3.01e-04	183	32	3	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DNM3 NTN4 FRY	3.01e-04	183	32	3	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	OBSCN FRY PDE3A	3.06e-04	184	32	3	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	3.11e-04	185	32	3	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	OBSCN FRY PDE3A	3.11e-04	185	32	3	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NTN4 FRY PDE3A	3.21e-04	187	32	3	406ff9327d3109fe1e251629c4c617b00a573dc2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 FRY PDE3A	3.31e-04	189	32	3	032f169e8ede653117919bf97c17f92043320b3c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MCF2 FRY PDE3A	3.31e-04	189	32	3	07208d32afca6f93207a2ac35b647b31a9f71b7c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	DNM3 FRY DNM1	3.36e-04	190	32	3	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	3.36e-04	190	32	3	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NTN4 FRY PDE3A	3.36e-04	190	32	3	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PYGL FRY ABHD12B	3.41e-04	191	32	3	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PYGL FRY ABHD12B	3.41e-04	191	32	3	f9a46956778a8773d6656340ecf5d218376d79c2
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NTN4 PDE3A PYROXD2	3.46e-04	192	32	3	fee99ca7e658963acf968aa724ef8c96cfc00a5d
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NTN4 FRY IKZF2	3.46e-04	192	32	3	b73f24d1c55dfef1eb01c26da117dbf637ea080a
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	3.52e-04	193	32	3	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Vascular_SMC_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NTN4 FRY PDE3A	3.52e-04	193	32	3	360079cbaa18b74e4a48c5de40844faca076e1a6
ToppCell	PCW_13-14-Epithelial-Epithelial_airway\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NTN4 FRY IKZF2	3.57e-04	194	32	3	7b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NTN4 FRY PDE3A	3.62e-04	195	32	3	5dc874641ad9537e4c1369825c1fb0a59f12a83d
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN FRY PDE3A	3.62e-04	195	32	3	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NTN4 FRY IKZF2	3.68e-04	196	32	3	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NTN4 FRY PDE3A	3.68e-04	196	32	3	1d94cecd378a829dd8014fc086d7fca48c953a91
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NTN4 FRY PDE3A	3.68e-04	196	32	3	aacec48285bcb7ccf1b538187071885e3602cc49
ToppCell	PCW_13-14-Epithelial\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NTN4 FRY IKZF2	3.79e-04	198	32	3	48eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PYGL FRY PDE3A	3.90e-04	200	32	3	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	mild-NK_CD56bright\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	IKZF2 TTLL10 PYROXD2	3.90e-04	200	32	3	a195bc6784346f706d4cd5b740adac1d950ce88a
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PYGL FRY PDE3A	3.90e-04	200	32	3	7c673ad0ea503ebd196579684d25d5f9e6a41030
Drug	library 2	DNM3 MCF2 DNM1 DNM2	1.23e-08	19	32	4	CID005270634
Drug	Go7874	DNM3 DNM1 DNM2	5.50e-07	12	32	3	CID005327863
Drug	AC1L9JXQ	DNM3 DNM1 DNM2	1.34e-05	33	32	3	CID000446658
Drug	Asp-pro	DNM3 PYGL DNM1 DNM2	1.34e-05	104	32	4	CID000170612
Drug	Spider Venoms	KCND1 DNM2	1.91e-05	5	32	2	ctd:D013111
Drug	NSC3364	DNM3 DNM1 CYP8B1 DNM2	2.20e-05	118	32	4	CID000025439
Drug	fisetin	BLMH DNM1 SIRT1	2.41e-05	40	32	3	CID005281614
Drug	2gzl	DNM3 DNM1 DNM2	3.67e-05	46	32	3	CID006102719
Drug	silibinin	PDE3A DNM1 UGT1A7 SIRT1 CCNC	4.53e-05	285	32	5	CID000005213
Drug	etorphine	DNM3 DNM1 DNM2	7.77e-05	59	32	3	CID000026721
Drug	1,3-di-o-tolylguanidine	DNM3 DNM1 DNM2	8.59e-05	61	32	3	CID000007333
Disease	centronuclear myopathy 1 (implicated_via_orthology)	DNM3 DNM1 DNM2	1.05e-08	5	31	3	DOID:0111223 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)	DNM3 DNM1 DNM2	1.05e-08	5	31	3	DOID:0110197 (implicated_via_orthology)
Disease	microcytic anemia (implicated_via_orthology)	DNM3 DNM1 DNM2	1.05e-08	5	31	3	DOID:11252 (implicated_via_orthology)
Disease	collagen disease (implicated_via_orthology)	DNM3 DNM1 DNM2	2.30e-07	12	31	3	DOID:854 (implicated_via_orthology)
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	DNM3 DNM1 DNM2	2.98e-07	13	31	3	DOID:0112202 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	DNM3 DNM1 DNM2	1.26e-05	43	31	3	DOID:2476 (implicated_via_orthology)
Disease	rectum cancer	PYGL ABHD12B	8.96e-04	42	31	2	EFO_1000657
Disease	middle cerebral artery infarction (implicated_via_orthology)	SIRT1 DNMT3A	1.03e-03	45	31	2	DOID:3525 (implicated_via_orthology)
Disease	Thrombus	PDE3A SIRT1	1.07e-03	46	31	2	C0087086
Disease	myopathy (implicated_via_orthology)	DNM2 MYBPC2	1.17e-03	48	31	2	DOID:423 (implicated_via_orthology)
Disease	Thrombosis	PDE3A SIRT1	1.22e-03	49	31	2	C0040053
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	CYP8B1 SIRT1	2.13e-03	65	31	2	DOID:0080208 (biomarker_via_orthology)
Disease	calcium measurement	DNAH2 PDE3A PYROXD2 DNMT3A	4.05e-03	628	31	4	EFO_0004838
Disease	Uterine leiomyoma	DNAH2 DNM3	4.13e-03	91	31	2	HP_0000131

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFEFYRLLHDARPKE	DNMT3A	731	Q9Y6K1
KEHVFLPLIDMLIYF	ABHD12B	61	Q7Z5M8
KEFPYRMNHILECEF	CCNC	126	P24863
EYFFDRDPDMFRHVL	KCND1	81	Q9NSA2
PQYLEMEFKERFVVH	INTS1	526	Q8N201
FHERFPFELVKMEFD	DNM1	366	Q05193
FHERFPFEIVKMEFN	DNM3	366	Q9UQ16
LIKEDHNLHEPMYFF	OR51B5	46	Q9H339
EAFKIPIREFMNYFH	PDE3A	726	Q14432
FHERFPFELVKMEFD	DNM2	366	P50570
GEKLMRFSYPDIHFD	IKZF2	286	Q9UKS7
DLYDIKYLPFEFMIF	OBSCN	7311	Q5VST9
YLPFFLMEKTLFLYH	POMT1	651	Q9Y6A1
FYIMVDAFFKLPDIE	GLT6D1	111	Q7Z4J2
AFEIDKMYTPLFFAR	FBXO9	421	Q9UK97
HVIRMYFLGFEAPEK	BRWD1	346	Q9NSI6
LEFYREHVKPLFNME	BLMH	251	Q13867
PMQRHLFLYEKAIVF	MCF2	721	P10911
FFRIKMYPVEDFEAS	FRY	276	Q5TBA9
DMYLETKRHIFPRFY	DNAH2	1521	Q9P225
MLRIKEPLHFFEDYF	EFCAB3	266	Q8N7B9
ELFMEFRKFDLLFPR	CYP8B1	201	Q9UNU6
LEAEFYFTHLIVMFK	NTN4	121	Q9HB63
MFDIEYFRKDPRPFF	SIRT1	296	Q96EB6
VRMHLYPADFRFDKP	ZNF511	166	Q8NB15
AQVFPKYEEFMHRLA	PYROXD2	156	Q8N2H3
PDLFKDIINMLFYHD	PYGL	756	P06737
DIINMLFYHDRFKVF	PYGL	761	P06737
MEEFFPETYRLDLKH	TTLL10	281	Q6ZVT0
DLLSMELPEFFRDYF	VPS33B	151	Q9H267
IMHLEEHLFCPYFFK	UGT1A7	211	Q9HAW7
MFIKEDLILPHYHTF	FAM50B	236	Q9Y247
PFEYKEHDFRMAPKF	MYBPC2	1036	Q14324