Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX1 DUOX2	1.51e-05	2	78	2	GO:0106293
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX1 DUOX2	1.49e-04	5	78	2	GO:0106294
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	6.64e-04	10	78	2	GO:0001849
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	C3P1 SPINT2 C3 C4A C4B	6.98e-04	180	78	5	GO:0004866
GeneOntologyMolecularFunction	peptidase inhibitor activity	C3P1 SPINT2 C3 C4A C4B	8.29e-04	187	78	5	GO:0030414
GeneOntologyMolecularFunction	dynactin binding	SPTBN5 HTT	9.69e-04	12	78	2	GO:0034452
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 DUOX2	9.69e-04	12	78	2	GO:0016174
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	DUOX1 DUOX2	9.69e-04	12	78	2	GO:0016175
GeneOntologyMolecularFunction	endopeptidase regulator activity	C3P1 SPINT2 C3 C4A C4B	1.14e-03	201	78	5	GO:0061135
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C3 C4A C4B	2.55e-06	8	75	3	GO:2000427
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C3 C4A C4B	5.44e-06	10	75	3	GO:2000425
GeneOntologyBiologicalProcess	apoptotic cell clearance	C3 C4A C4B MERTK	2.78e-05	48	75	4	GO:0043277
GeneOntologyBiologicalProcess	cuticle development	DUOX1 DUOX2	3.90e-05	3	75	2	GO:0042335
GeneOntologyBiologicalProcess	spindle localization	SPIRE2 ASPM ZW10 HTT	1.04e-04	67	75	4	GO:0051653
GeneOntologyBiologicalProcess	retina development in camera-type eye	TTC8 PDE6C PDE6B C3 MERTK IHH	1.19e-04	211	75	6	GO:0060041
GeneOntologyBiologicalProcess	regulation of phagocytosis	C3 C4A C4B MERTK FER1L5	1.38e-04	136	75	5	GO:0050764
GeneOntologyBiologicalProcess	protein depolymerization	SPTBN4 SPTBN5 LMOD3 ATXN7 HTT	1.80e-04	144	75	5	GO:0051261
GeneOntologyBiologicalProcess	regulation of DNA metabolic process	MSH6 SPIRE2 EP400 ATXN7 MCIDAS CIZ1 PRKCQ ANKLE1 BABAM2	2.02e-04	564	75	9	GO:0051052
GeneOntologyBiologicalProcess	sexual reproduction	SPTBN4 MSH6 SPIRE2 BCL2L10 ASPM NXF2 DUOX2 YTHDC2 ANKLE1 MERTK IHH ZW10 ANAPC5 HTT	2.39e-04	1312	75	14	GO:0019953
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	3.79e-04	8	78	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	4.86e-04	9	78	2	GO:0044217
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTBN5	4.86e-04	9	78	2	GO:0008091
Domain	Anaphylatoxin_comp_syst	C3 C4A C4B	6.44e-07	5	76	3	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C3 C4A C4B	6.44e-07	5	76	3	IPR001840
Domain	Terpenoid_cyclase/PrenylTrfase	C3 LSS C4A C4B	7.42e-07	18	76	4	IPR008930
Domain	ANATO	C3 C4A C4B	2.24e-06	7	76	3	SM00104
Domain	ANATO	C3 C4A C4B	2.24e-06	7	76	3	PF01821
Domain	ANAPHYLATOXIN_2	C3 C4A C4B	2.24e-06	7	76	3	PS01178
Domain	ANAPHYLATOXIN_1	C3 C4A C4B	2.24e-06	7	76	3	PS01177
Domain	Anaphylatoxin/fibulin	C3 C4A C4B	2.24e-06	7	76	3	IPR000020
Domain	Thiol-ester_cl	C3 C4A C4B	3.57e-06	8	76	3	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C3 C4A C4B	3.57e-06	8	76	3	IPR019565
Domain	MacrogloblnA2_CS	C3 C4A C4B	3.57e-06	8	76	3	IPR019742
Domain	A2M_N	C3 C4A C4B	7.61e-06	10	76	3	PF01835
Domain	A2M_N	C3 C4A C4B	7.61e-06	10	76	3	IPR002890
Domain	A-macroglobulin_rcpt-bd	C3 C4A C4B	7.61e-06	10	76	3	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C3 C4A C4B	7.61e-06	10	76	3	PS00477
Domain	A2M	C3 C4A C4B	7.61e-06	10	76	3	PF00207
Domain	A2M_N_2	C3 C4A C4B	7.61e-06	10	76	3	IPR011625
Domain	A2M_comp	C3 C4A C4B	7.61e-06	10	76	3	IPR011626
Domain	A2M_N_2	C3 C4A C4B	7.61e-06	10	76	3	PF07703
Domain	A2M_recep	C3 C4A C4B	7.61e-06	10	76	3	PF07677
Domain	A2M_comp	C3 C4A C4B	7.61e-06	10	76	3	PF07678
Domain	Macroglobln_a2	C3 C4A C4B	7.61e-06	10	76	3	IPR001599
Domain	-	C3 LSS C4A	1.39e-05	12	76	3	1.50.10.20
Domain	DUOX1	DUOX1 DUOX2	1.63e-05	2	76	2	IPR029595
Domain	C345C	C3 C4A C4B	4.23e-05	17	76	3	SM00643
Domain	NTR	C3 C4A C4B	5.99e-05	19	76	3	PF01759
Domain	Netrin_module_non-TIMP	C3 C4A C4B	5.99e-05	19	76	3	IPR018933
Domain	-	C3 C4A	9.75e-05	4	76	2	1.20.91.20
Domain	NTR	C3 C4A C4B	1.08e-04	23	76	3	PS50189
Domain	Netrin_domain	C3 C4A C4B	1.08e-04	23	76	3	IPR001134
Domain	TIMP-like_OB-fold	C3 C4A C4B	1.57e-04	26	76	3	IPR008993
Domain	NAD_binding_6	DUOX1 DUOX2	3.39e-04	7	76	2	PF08030
Domain	FAD_binding_8	DUOX1 DUOX2	3.39e-04	7	76	2	PF08022
Domain	GAF	PDE6C PDE6B	3.39e-04	7	76	2	PF01590
Domain	FAD-bd_8	DUOX1 DUOX2	3.39e-04	7	76	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX1 DUOX2	3.39e-04	7	76	2	IPR013121
Domain	GAF	PDE6C PDE6B	4.50e-04	8	76	2	IPR003018
Domain	GAF	PDE6C PDE6B	4.50e-04	8	76	2	SM00065
Domain	A2M_N_2	C3 C4A	4.50e-04	8	76	2	SM01359
Domain	-	C3 C4A	4.50e-04	8	76	2	2.60.40.690
Domain	A2M_recep	C3 C4A	4.50e-04	8	76	2	SM01361
Domain	A2M	C3 C4A	4.50e-04	8	76	2	SM01360
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN5	5.77e-04	9	76	2	IPR001605
Domain	GAF_dom-like	PDE6C PDE6B	5.77e-04	9	76	2	IPR029016
Domain	-	PDE6C PDE6B	5.77e-04	9	76	2	3.30.450.40
Domain	Haem_peroxidase	DUOX1 DUOX2	7.20e-04	10	76	2	IPR010255
Domain	An_peroxidase	DUOX1 DUOX2	7.20e-04	10	76	2	PF03098
Domain	PEROXIDASE_3	DUOX1 DUOX2	7.20e-04	10	76	2	PS50292
Domain	Haem_peroxidase_animal	DUOX1 DUOX2	7.20e-04	10	76	2	IPR019791
Domain	-	DUOX1 DUOX2	7.20e-04	10	76	2	1.10.640.10
Domain	TPR_7	TTC8 TTC28	7.20e-04	10	76	2	PF13176
Domain	Ferric_reduct	DUOX1 DUOX2	1.05e-03	12	76	2	PF01794
Domain	Fe3_Rdtase_TM_dom	DUOX1 DUOX2	1.05e-03	12	76	2	IPR013130
Domain	CH	SPTBN4 SPTBN5 ASPM	2.36e-03	65	76	3	SM00033
Domain	ARM-type_fold	ASPM HEATR5B TNPO3 NCDN HTT ITPR2	2.57e-03	339	76	6	IPR016024
Domain	Fd_Rdtase_FAD-bd	DUOX1 DUOX2	2.67e-03	19	76	2	IPR017927
Domain	FAD_FR	DUOX1 DUOX2	2.67e-03	19	76	2	PS51384
Domain	PDEase	PDE6C PDE6B	2.67e-03	19	76	2	IPR023088
Domain	Riboflavin_synthase-like_b-brl	DUOX1 DUOX2	2.67e-03	19	76	2	IPR017938
Domain	CH	SPTBN4 SPTBN5 ASPM	2.91e-03	70	76	3	PF00307
Domain	IGFBP-like	CCN5 HTRA4	2.96e-03	20	76	2	IPR000867
Domain	IGFBP	CCN5 HTRA4	2.96e-03	20	76	2	PF00219
Domain	IGFBP_N_2	CCN5 HTRA4	2.96e-03	20	76	2	PS51323
Domain	-	SPTBN4 SPTBN5 ASPM	3.03e-03	71	76	3	1.10.418.10
Domain	PDEase_I	PDE6C PDE6B	3.26e-03	21	76	2	PF00233
Domain	WH2_dom	LMOD3 SPIRE2	3.26e-03	21	76	2	IPR003124
Domain	PDEASE_I	PDE6C PDE6B	3.26e-03	21	76	2	PS00126
Domain	PDEase_CS	PDE6C PDE6B	3.26e-03	21	76	2	IPR023174
Domain	CH	SPTBN4 SPTBN5 ASPM	3.28e-03	73	76	3	PS50021
Domain	CH-domain	SPTBN4 SPTBN5 ASPM	3.54e-03	75	76	3	IPR001715
Domain	-	PDE6C PDE6B	3.58e-03	22	76	2	1.10.1300.10
Domain	Actinin_actin-bd_CS	SPTBN4 SPTBN5	3.91e-03	23	76	2	IPR001589
Domain	Spectrin	SPTBN4 SPTBN5	3.91e-03	23	76	2	PF00435
Domain	PDEase_catalytic_dom	PDE6C PDE6B	3.91e-03	23	76	2	IPR002073
Domain	ACTININ_2	SPTBN4 SPTBN5	3.91e-03	23	76	2	PS00020
Domain	ACTININ_1	SPTBN4 SPTBN5	3.91e-03	23	76	2	PS00019
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C3 C4A C4B	2.41e-06	7	59	3	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C3 C4A C4B	3.84e-06	8	59	3	M27031
Pathway	BIOCARTA_LECTIN_PATHWAY	C3 C4A C4B	1.12e-05	11	59	3	MM1430
Pathway	BIOCARTA_CLASSIC_PATHWAY	C3 C4A C4B	1.49e-05	12	59	3	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C3 C4A C4B	1.93e-05	13	59	3	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C3 C4A C4B	3.06e-05	15	59	3	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C3 C4A C4B	4.54e-05	17	59	3	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C3 C4A C4B	4.54e-05	17	59	3	MM1369
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	GZMM C3 C4A C4B	7.49e-05	54	59	4	MM14655
Pathway	BIOCARTA_COMP_PATHWAY	C3 C4A C4B	7.55e-05	20	59	3	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C3 C4A C4B	1.01e-04	22	59	3	M39502
Pathway	REACTOME_ALTERNATIVE_COMPLEMENT_ACTIVATION	GZMM C3	1.71e-04	5	59	2	M27024
Pathway	REACTOME_ALTERNATIVE_COMPLEMENT_ACTIVATION	GZMM C3	1.71e-04	5	59	2	MM14674
Pathway	REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT	GZMM C3 C4A C4B	3.45e-04	80	59	4	M6121
Pathway	REACTOME_COMPLEMENT_CASCADE	GZMM C3 C4A C4B	4.16e-04	84	59	4	MM14653
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	4.74e-04	8	59	2	M47872
Pathway	REACTOME_THYROXINE_BIOSYNTHESIS	DUOX1 DUOX2	6.08e-04	9	59	2	MM14833
Pathway	REACTOME_THYROXINE_BIOSYNTHESIS	DUOX1 DUOX2	7.58e-04	10	59	2	M27120
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTBN5	7.58e-04	10	59	2	MM15112
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	9.24e-04	11	59	2	M47874
Pathway	WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY	C3 C4A C4B MERTK	1.00e-03	106	59	4	M42535
Pathway	REACTOME_COMPLEMENT_CASCADE	GZMM C3 C4A C4B	1.35e-03	115	59	4	M19752
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	GALNT15 SPTBN4 SPTBN5 OTOA ARSJ ATXN7 PSMA1 MBD1 FBXO41 UBA2 C3 C4A C4B BABAM2	1.45e-03	1389	59	14	MM15307
Pubmed	Genetic polymorphism of murine C3 controlled by a single co-dominant locus on chromosome 17.	C3 C4A C4B	1.09e-08	3	78	3	681746
Pubmed	Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma.	C3 C4A C4B	1.09e-08	3	78	3	35017157
Pubmed	Genetic evidence for involvement of classical complement pathway in induction of experimental autoimmune myasthenia gravis.	C3 C4A C4B	1.09e-08	3	78	3	14500686
Pubmed	In vitro C3 deposition on Cryptococcus capsule occurs via multiple complement activation pathways.	C3 C4A C4B	1.09e-08	3	78	3	21723612
Pubmed	Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria.	C3 C4A C4B	1.09e-08	3	78	3	9829481
Pubmed	Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.	C3 C4A C4B	1.09e-08	3	78	3	16893076
Pubmed	Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.	C3 C4A C4B	1.09e-08	3	78	3	8524789
Pubmed	Complement C4-deficient mice have a high mortality rate during PTZ-induced epileptic seizures, which correlates with cognitive problems and the deficiency in the expression of Egr1 and other immediate early genes.	C3 C4A C4B	1.09e-08	3	78	3	37234916
Pubmed	Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli.	C3 C4A C4B	1.09e-08	3	78	3	11433344
Pubmed	Immune complex glomerulonephritis in C4- and C3-deficient mice.	C3 C4A C4B	1.09e-08	3	78	3	9461092
Pubmed	Regulation of the B cell response to T-dependent antigens by classical pathway complement.	C3 C4A C4B	1.09e-08	3	78	3	8752901
Pubmed	Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement.	C3 C4A C4B	1.09e-08	3	78	3	9218619
Pubmed	Complement genes contribute sex-biased vulnerability in diverse disorders.	C3 C4A C4B	1.09e-08	3	78	3	32499649
Pubmed	Role of complement in a murine model of peanut-induced anaphylaxis.	C3 C4A C4B	1.09e-08	3	78	3	23182714
Pubmed	Impaired mast cell-dependent natural immunity in complement C3-deficient mice.	C3 C4A C4B	4.33e-08	4	78	3	9367154
Pubmed	The alternative activation pathway and complement component C3 are critical for a protective immune response against Pseudomonas aeruginosa in a murine model of pneumonia.	C3 C4A C4B	4.33e-08	4	78	3	15102802
Pubmed	Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells.	C3 C4A C4B	4.33e-08	4	78	3	16304047
Pubmed	Efficient amyloid A clearance in the absence of immunoglobulins and complement factors.	C3 C4A C4B	4.33e-08	4	78	3	23454183
Pubmed	The human complement system: assembly of the classical pathway C3 convertase.	C3 C4A C4B	4.33e-08	4	78	3	6906228
Pubmed	Functional analysis of Ficolin-3 mediated complement activation.	C3 C4A C4B	4.33e-08	4	78	3	21085669
Pubmed	Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice.	C3 C4A C4B	4.33e-08	4	78	3	9409643
Pubmed	Complement C4 is protective for lupus disease independent of C3.	C3 C4A C4B	4.33e-08	4	78	3	11801636
Pubmed	A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo.	C3 C4A C4B	4.33e-08	4	78	3	10934224
Pubmed	Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.	C3 C4A C4B	4.33e-08	4	78	3	30301856
Pubmed	Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris.	C3 C4A C4B	4.33e-08	4	78	3	11803045
Pubmed	Intestinal reperfusion injury is mediated by IgM and complement.	C3 C4A C4B	4.33e-08	4	78	3	10066708
Pubmed	Antigen localization within the splenic marginal zone restores humoral immune response and IgG class switch in complement C4-deficient mice.	C3 C4A C4B	4.33e-08	4	78	3	15477230
Pubmed	Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells.	C3 C4A C4B	4.33e-08	4	78	3	19302245
Pubmed	Evidence for non-traditional activation of complement factor C3 during murine liver regeneration.	C3 C4A C4B	4.33e-08	4	78	3	18452991
Pubmed	Phylogeny of the C3/C4/C5 complement-component gene family indicates that C5 diverged first.	C3 C4A C4B	4.33e-08	4	78	3	8015436
Pubmed	Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.	C3 C4A C4B	1.08e-07	5	78	3	25039245
Pubmed	Both complement and IgG fc receptors are required for development of attenuated antiglomerular basement membrane nephritis in mice.	C3 C4A C4B	1.08e-07	5	78	3	19710463
Pubmed	The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand.	C3 C4A C4B	1.08e-07	5	78	3	16783845
Pubmed	Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.	C3 C4A C4B	1.08e-07	5	78	3	18056835
Pubmed	Complement proteins C3 and C4 bind to collagen and elastin in the vascular wall: a potential role in vascular stiffness and atherosclerosis.	C3 C4A C4B	1.08e-07	5	78	3	21707943
Pubmed	Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia.	C3 C4A C4B	1.08e-07	5	78	3	15192652
Pubmed	A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.	C3 C4A C4B	1.08e-07	5	78	3	9382884
Pubmed	Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.	C3 C4A C4B	1.08e-07	5	78	3	29743491
Pubmed	Protective T cell-independent antiviral antibody responses are dependent on complement.	C3 C4A C4B	1.08e-07	5	78	3	10523614
Pubmed	Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.	C3 C4A C4B	1.08e-07	5	78	3	17947689
Pubmed	Formation of high affinity C5 convertase of the classical pathway of complement.	C3 C4A C4B	1.08e-07	5	78	3	12878586
Pubmed	The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.	C3 C4A C4B	1.08e-07	5	78	3	22689574
Pubmed	Predominant role for C5b-9 in renal ischemia/reperfusion injury.	C3 C4A C4B	1.08e-07	5	78	3	10811844
Pubmed	Complement C4A Regulates Autoreactive B Cells in Murine Lupus.	C3 C4A C4B	1.08e-07	5	78	3	33147456
Pubmed	CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.	C3 C4A C4B	2.16e-07	6	78	3	19710450
Pubmed	Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice.	C3 C4A C4B	2.16e-07	6	78	3	17363917
Pubmed	Modulation of the antitumor immune response by complement.	C3 C4A C4B	2.16e-07	6	78	3	18820683
Pubmed	Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophages in vitro.	C3 C4A C4B	2.16e-07	6	78	3	15597324
Pubmed	A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.	C3 C4A C4B	2.16e-07	6	78	3	16615889
Pubmed	Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.	C3 C4A C4B	3.77e-07	7	78	3	20139276
Pubmed	Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors.	C3 C4A C4B	3.77e-07	7	78	3	12055255
Pubmed	A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.	C3 C4A C4B	3.77e-07	7	78	3	22037602
Pubmed	Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking.	C3 C4A C4B	3.77e-07	7	78	3	29233958
Pubmed	Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis.	C3 C4A C4B	6.03e-07	8	78	3	20870940
Pubmed	Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection.	C3 C4A C4B	6.03e-07	8	78	3	28301559
Pubmed	Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping.	C3 C4A C4B	6.03e-07	8	78	3	30173917
Pubmed	Divergent immunoglobulin g subclass activity through selective Fc receptor binding.	C3 C4A C4B	6.03e-07	8	78	3	16322460
Pubmed	Impaired antibody response causes persistence of prototypic T cell-contained virus.	C3 C4A C4B	6.03e-07	8	78	3	19355789
Pubmed	C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.	C3 C4A C4B	6.03e-07	8	78	3	24474777
Pubmed	Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway.	C3 C4A C4B	6.03e-07	8	78	3	14670299
Pubmed	The role of complement in cryoglobulin-induced immune complex glomerulonephritis.	C3 C4A C4B	6.03e-07	8	78	3	16272350
Pubmed	Surviving mousepox infection requires the complement system.	C3 C4A C4B	9.03e-07	9	78	3	19112490
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPIRE2 ARSJ EP400 SBF2 ANKLE1 HERC1 PLXNB2 BABAM2 TNPO3 MED13 CEP170B HTT ITPR2	1.02e-06	1105	78	13	35748872
Pubmed	Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.	C3 C4A C4B	1.29e-06	10	78	3	21943708
Pubmed	Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling.	C3 C4A C4B	1.29e-06	10	78	3	30429287
Pubmed	Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.	C3 C4A C4B	1.77e-06	11	78	3	23204401
Pubmed	Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.	C3 C4A C4B	2.35e-06	12	78	3	18524992
Pubmed	The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity.	C3 C4A C4B	2.35e-06	12	78	3	31801071
Pubmed	Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome 17.	C3 C4A C4B	3.05e-06	13	78	3	1970332
Pubmed	Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice.	C3 C4A C4B	3.05e-06	13	78	3	23427256
Pubmed	Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position.	C3 C4A C4B	4.84e-06	15	78	3	2885372
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	4.97e-06	2	78	2	22737222
Pubmed	The early predictive role of complement C3 and C4 in patients with acute pancreatitis.	C3 C4A	4.97e-06	2	78	2	32187754
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	4.97e-06	2	78	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	4.97e-06	2	78	2	15998580
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX1 DUOX2	4.97e-06	2	78	2	28633507
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	4.97e-06	2	78	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	4.97e-06	2	78	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	4.97e-06	2	78	2	3696167
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX1 DUOX2	4.97e-06	2	78	2	30375286
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	4.97e-06	2	78	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	4.97e-06	2	78	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	4.97e-06	2	78	2	19933335
Pubmed	Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.	PDE6C PDE6B	4.97e-06	2	78	2	30038560
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	4.97e-06	2	78	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	4.97e-06	2	78	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	4.97e-06	2	78	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	4.97e-06	2	78	2	12207352
Pubmed	Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.	PDE6C PDE6B	4.97e-06	2	78	2	26085644
Pubmed	Centenarian longevity is positively correlated with IgE levels but negatively correlated with C3/C4 levels, abdominal obesity and metabolic syndrome.	C3 C4A	4.97e-06	2	78	2	32132668
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	4.97e-06	2	78	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	4.97e-06	2	78	2	6559257
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX1 DUOX2	4.97e-06	2	78	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX1 DUOX2	4.97e-06	2	78	2	11514595
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	4.97e-06	2	78	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	4.97e-06	2	78	2	22387014
Pubmed	C4b-binding protein is present in affected areas of myocardial infarction during the acute inflammatory phase and covers a larger area than C3.	C3 C4B	4.97e-06	2	78	2	18682851
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	4.97e-06	2	78	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	4.97e-06	2	78	2	20506482
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX1 DUOX2	4.97e-06	2	78	2	24161126
Cytoband	15q21	SPTBN5 BCL2L10	1.55e-04	11	78	2	15q21
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C3 C4A C4B	1.65e-06	9	50	3	1234
GeneFamily	Complement system\|Sushi domain containing	C3 C4A C4B	1.33e-04	36	50	3	492
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTBN5	1.56e-04	7	50	2	1113
GeneFamily	Phosphodiesterases	PDE6C PDE6B	1.99e-03	24	50	2	681
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 UBA2 MYOCD HTRA4 PLXNB2 GFRA2	6.05e-07	173	78	6	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 UBA2 MYOCD HTRA4 PLXNB2 GFRA2	6.05e-07	173	78	6	2acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC49A4 KBTBD12 MERTK CRHBP GFRA2 ITPR2	8.95e-07	185	78	6	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SPTBN5 DUOX1 FER1L5 CRHBP	5.55e-06	66	78	4	d6b202d9f5bebaac23b34b689ad306549dec0593
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4-Inhibitory_Neuron.Gad1Gad2.Igfbp4.Adora1_(Striatum,_interneuron)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SPTBN5 DUOX1 FER1L5 CRHBP	5.55e-06	66	78	4	4a714cf035b22da103054098f85f9170c56e9e83
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASPM LRRC4C HTRA4 MELK NCDN	1.03e-05	164	78	5	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASPM LRRC4C HTRA4 MELK NCDN	1.03e-05	164	78	5	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	Control-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	GALNT15 ZFHX4 C3 C4A C4B	1.09e-05	166	78	5	32ebaefa6c074b28193fff764ee7c2c0e9357e20
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC49A4 MERTK CRHBP GFRA2 ITPR2	2.10e-05	190	78	5	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LMOD3 MCIDAS MELK CRHBP	2.26e-05	94	78	4	c73e99890431750b74f984de5c82e33533ab708b
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LMOD3 MCIDAS MELK CRHBP	2.26e-05	94	78	4	1bda61101f45f5c4a68453087b880fdc6d9acfca
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LMOD3 MCIDAS MELK CRHBP	2.26e-05	94	78	4	9664f74bc0168c92fb8a68cad628323c476f6103
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SPTBN4 FBXO41 HERC1 CAMTA1 CEP170B	2.32e-05	194	78	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	DUOX1 NAB2 C3 LSS LRRC4C	2.37e-05	195	78	5	b0cea3f4e59635913d243612f2e8cf4c7b34e726
ToppCell	normal_Lung-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	C3 MERTK CRHBP GFRA2 ITPR2	2.55e-05	198	78	5	fbd72ebaba73cc30e79dc8a8c3d46b6f863c1494
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	ZFHX4 C3 ARHGAP28 C4A C4B	2.61e-05	199	78	5	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	OTOA MERTK CRHBP GFRA2 ITPR2	2.68e-05	200	78	5	4b4df0fe47498310d94448b8a289e58e4f5b5aa8
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-\|Striatum / BrainAtlas - Mouse McCarroll V32	LMOD3 PDE6C UBA2 MYOCD	3.77e-05	107	78	4	5907b9632c88d48f293c3c6d37b7ef831fbcdd86
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)\|Striatum / BrainAtlas - Mouse McCarroll V32	LMOD3 PDE6C UBA2 MYOCD	3.77e-05	107	78	4	d4807f008619dfd3e215d602df0d02b135b1ac37
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1\|Striatum / BrainAtlas - Mouse McCarroll V32	LMOD3 PDE6C UBA2 MYOCD	3.77e-05	107	78	4	3f24de1afbfd070f9db11c9acd02b90e5eb2511d
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATXN7 C4A C4B HTT	6.49e-05	123	78	4	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Nefl_(Neurofilament_state)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LMOD3 ASPM KBTBD12	7.21e-05	46	78	3	37ea73d291e35b6865bd3ea4857275a6e5b299d1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Nefl_(Neurofilament_state)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	LMOD3 ASPM KBTBD12	7.21e-05	46	78	3	69e9c8cbae3d15bd0823b8c6e48a9d2b9815296b
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_1-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Cdc20)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ASPM NXF2 ANKLE1 MELK	8.29e-05	131	78	4	f9fb8d74ca720b81fd5910cc975510359a8ef751
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LMOD3 ASPM HTRA4 MELK	1.13e-04	142	78	4	01c39bb90807fa3031ba4511712440380b6069af
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	LMOD3 ASPM PRKCQ GTF3C4	1.33e-04	148	78	4	80470353e12599440f711b6e107730763376d04d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPTBN5 ARSJ ZFHX4 MELK	1.33e-04	148	78	4	d5cace5605bff2bb8248fadb51f2dad7539930ba
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MCIDAS ASPM C4A MELK	1.36e-04	149	78	4	a6406c4c9404271a2f4c615c6cd3265b2d759b12
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NEK5 COX18 LRRC4C ZNF557	1.67e-04	157	78	4	f6210be2362d833c6d869ff921188bfc85dda11d
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	NEK5 COX18 LRRC4C ZNF557	1.67e-04	157	78	4	43a6b423fd70479822a564ff4225a1e4951ae5ed
ToppCell	Control-B_naive-12\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EXD2 SLC49A4 NCDN SPDYE16	1.67e-04	157	78	4	4803f601c1ba43260aa09172acc7964aac2c8ccf
ToppCell	Control-B_naive-12\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	EXD2 SLC49A4 NCDN SPDYE16	1.71e-04	158	78	4	41318f864770370ce77ed3fa4a84f76c0c22c482
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LRRC4C CRHBP GFRA2 ITPR2	1.92e-04	163	78	4	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PDE6C KBTBD12 CRHBP	2.03e-04	65	78	3	25d2f56f6cd982a227772f8a3b453cdcc8516a47
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PDE6C KBTBD12 CRHBP	2.03e-04	65	78	3	d7d571be0662967e6d8d934e45f928a2f9e1c06a
ToppCell	Control-Epithelial-Mesothelial\|Control / Disease state, Lineage and Cell class	ZFHX4 C3 C4A C4B	2.06e-04	166	78	4	1ed3788257e14f097862b999f020bfe2a57de52b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN5 PSMA1 KBTBD12 MELK	2.11e-04	167	78	4	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	droplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT15 ARHGAP28 COX18 MELK	2.11e-04	167	78	4	bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	OTOA PDE6B LSS ITPR2	2.16e-04	168	78	4	c51244b4bdbfd961e2725306aa9cb25dd66d58bd
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	GALNT15 ZFHX4 BCL2L10 CEP170B	2.21e-04	169	78	4	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASPM ANKLE1 MELK GFRA2	2.21e-04	169	78	4	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TTC28 GTF3C4 VAT1 ITPR2	2.21e-04	169	78	4	b66ffc2b2b6bfcc3a6e639d9d31d3de95f4a94e1
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	SPTBN5 OTOA TTC28 GFRA2	2.47e-04	174	78	4	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCN5 ZFHX4 C3 LRRC4C	2.47e-04	174	78	4	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCN5 ZFHX4 C3 LRRC4C	2.47e-04	174	78	4	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE6B C3 NCDN SPDYE16	2.52e-04	175	78	4	b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPINT2 RHOXF1 IHH ITPR2	2.52e-04	175	78	4	bffa623511ceb0b9bf76d87f9a10cfadfe0e940f
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASPM LRRC4C PLXNB2 MELK	2.52e-04	175	78	4	15c69dd5635c9251c535f1e22467712e9667ae92
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE6B C3 NCDN SPDYE16	2.52e-04	175	78	4	7ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT15 C3 C4A C4B	2.63e-04	177	78	4	0912a291cff32a4ff8a2d7680ed1a1cd867fb90f
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEK5 MCIDAS C3 ARHGAP28	2.69e-04	178	78	4	445fb243d738a34794d66f34b92dde1f3ea6738e
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B MERTK PLXNB2 GFRA2	2.69e-04	178	78	4	6c1b5087581ca8cea976d89ea6f34088c8fc3668
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOCD HTRA4 PLXNB2 GFRA2	2.69e-04	178	78	4	7467e5ab2fcb39cc4a2c7dd69722c91def3b6aea
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARSJ C3 PRKCQ PLXNB2	2.75e-04	179	78	4	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM ANKLE1 MELK CRHBP	2.75e-04	179	78	4	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	IPF-Epithelial-Mesothelial\|IPF / Disease state, Lineage and Cell class	ZFHX4 C3 C4A C4B	2.81e-04	180	78	4	1fa54bf4dba72866b2295639d991af639341bc08
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 PRKCQ LRRC4C GFRA2	2.81e-04	180	78	4	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 DUOX1 ZFHX4 C4B	2.81e-04	180	78	4	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	ASPM PLXNB2 MELK GFRA2	2.81e-04	180	78	4	4eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 PRKCQ LRRC4C GFRA2	2.81e-04	180	78	4	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 PRKCQ LRRC4C GFRA2	2.81e-04	180	78	4	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARSJ ASPM C3 C4A	2.87e-04	181	78	4	65eaa9bc1022bcf0c5f0f92c07a2cbbf11f9b59c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(PRG4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARSJ ASPM C3 C4A	2.87e-04	181	78	4	eaac7d58117eddfff06b25521efc431c1351d592
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT2 NEK5 MYOCD GFRA2	2.87e-04	181	78	4	c1b1e62440805800a3a600b1ddd79be1c9762598
ToppCell	BAL-Control-Myeloid-Macrophage\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OTOA MERTK HTRA4 CRHBP	2.99e-04	183	78	4	8e9d45c96b44558158e3d59613f64a73d5390c19
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KBTBD12 PRKCQ LRRC4C GFRA2	2.99e-04	183	78	4	876b4f128c2168fdae7488201ff44f19c06c8415
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KBTBD12 PRKCQ LRRC4C GFRA2	2.99e-04	183	78	4	b190b650e61b1b20baf5e42d04acac82d3fd1400
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OTOA MERTK HTRA4 CRHBP	2.99e-04	183	78	4	0408d991ddb639594b45d5cb2432dd29289167b1
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OTOA MERTK HTRA4 CRHBP	2.99e-04	183	78	4	79f05b8a967124d831b0baef137e30659f5917a7
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ZFHX4 MYOCD LRRC4C	3.05e-04	184	78	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OTOA MERTK HTRA4 CRHBP	3.05e-04	184	78	4	92202e1cd0bba1ce4b061ebcb8a2af5bb590542a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ZFHX4 MYOCD LRRC4C	3.05e-04	184	78	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ZFHX4 MYOCD LRRC4C	3.05e-04	184	78	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	BAL-Control-Myeloid-Macrophage\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	OTOA MERTK HTRA4 CRHBP	3.05e-04	184	78	4	7331535d469453a5264dcb0270a97f63d3b55201
ToppCell	BAL-Control-Myeloid-Macrophage-transitional_Macro\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	OTOA MERTK HTRA4 CRHBP	3.05e-04	184	78	4	337e38a6b2b6770cc992d88b006829f194841b10
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-sinusoidal_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GALNT15 SPIRE2 ARHGAP28 CRHBP	3.18e-04	186	78	4	e8ead5634686ebaa6a230eea69795d923ce9939d
ToppCell	343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MERTK CRHBP GFRA2 ITPR2	3.18e-04	186	78	4	9673367cb53bafb873a01ef6bda11d9f392ce648
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ZFHX4 C3 C4A C4B	3.18e-04	186	78	4	7812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	ASPM C4A C4B MERTK	3.18e-04	186	78	4	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 ZFHX4 C3	3.18e-04	186	78	4	7582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCell	facs-Skin-Anagen-24m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 C3 ARHGAP28 C4B	3.24e-04	187	78	4	908df5520142d65fe32a003d26be14965082a1ea
ToppCell	facs-Skin-Anagen-24m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 C3 ARHGAP28 C4B	3.24e-04	187	78	4	c1dfab0b0d7f519b9f13f4e0365ab41c4b2ae1ec
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUOX1 C3 HTRA4 VAT1	3.24e-04	187	78	4	0d4b7da81036c2aa678654b9fe49c939d08fcd9b
ToppCell	facs-Skin-Anagen-24m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 C3 ARHGAP28 C4B	3.24e-04	187	78	4	b486cc5ac678051fea9d4c7db53b26a5a8427e60
ToppCell	LPS-IL1RA-Epithelial_alveolar\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARSJ SPINT2 C3 PRKCQ	3.31e-04	188	78	4	6164d467b612767ceba15de34176bcc8e8c36ab8
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPIRE2 ZFHX4 LRRC4C GFRA2	3.31e-04	188	78	4	921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)--\|Striatum / BrainAtlas - Mouse McCarroll V32	BCL2L10 ARHGAP28 CRHBP	3.34e-04	77	78	3	7bb18406d404c51ee938cc577c155dc51868ddb9
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)\|Striatum / BrainAtlas - Mouse McCarroll V32	BCL2L10 ARHGAP28 CRHBP	3.34e-04	77	78	3	ac311740424ff75b478b3c19fa0fae93776eb54e
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Chodl_(Low-threshold_spiking_interneuron,_Npy+/Sst+)-\|Striatum / BrainAtlas - Mouse McCarroll V32	BCL2L10 ARHGAP28 CRHBP	3.34e-04	77	78	3	9f2dbf922acb905d636427a766a217c0db9671d2
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARSJ SPINT2 C3 PRKCQ	3.38e-04	189	78	4	5f883ef4cc0383142d538ae61f4fb40dfdb8ef18
ToppCell	facs-Skin-Anagen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARSJ ASPM ANKLE1 MELK	3.38e-04	189	78	4	bfa3ed1360991a3e32fad133017c413f8adc1eba
ToppCell	facs-Skin-Anagen-3m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARSJ ASPM ANKLE1 MELK	3.38e-04	189	78	4	96f10c63656e446b4bb712f012e91ae986f8c2d0
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 C3 C4B VAT1	3.44e-04	190	78	4	dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 C3 C4B VAT1	3.44e-04	190	78	4	0bb06df3d5a50416854370f234718c6cec3d773b
ToppCell	facs-SCAT-Fat-24m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFHX4 C3 C4B VAT1	3.44e-04	190	78	4	008290bb5c79446681dd6bf354336c57ad0d6f13
ToppCell	356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	OTOA MERTK CRHBP ITPR2	3.44e-04	190	78	4	d541e076137cf7334bdb0ed69db2f9a27c668c65
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|368C / Donor, Lineage, Cell class and subclass (all cells)	MERTK CRHBP GFRA2 ITPR2	3.44e-04	190	78	4	cbba3d94a4c3e0b0d14f3b7c60dba5d6e097c5e3
ToppCell	Control-Myeloid-transitional_Macro\|Control / Disease group,lineage and cell class （2021.01.30）	OTOA MERTK HTRA4 CRHBP	3.51e-04	191	78	4	3ed0b1ff628a165e3c92c2e493206015f57dccfe
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT15 C3 C4B HTRA4	3.51e-04	191	78	4	2b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT15 C3 C4B HTRA4	3.58e-04	192	78	4	7b48df661f61ce494bf6f0b9a74b0422e29c24bf
Computational	Complement.	C3 C4A C4B	1.07e-04	23	44	3	MODULE_130
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 DUOX2 IHH	1.31e-06	9	75	3	DOID:0050338 (implicated_via_orthology)
Disease	age at menopause	GALNT15 MSH6 ZFHX4 TTC28 BABAM2 TNPO3 VAT1	1.20e-05	302	75	7	EFO_0004704
Disease	phenylketonuria (implicated_via_orthology)	DUOX1 DUOX2	3.81e-05	4	75	2	DOID:9281 (implicated_via_orthology)
Disease	Complement deficiency disease	C3 C4A C4B	8.15e-05	33	75	3	C0272242
Disease	retinal degeneration (implicated_via_orthology)	PDE6C PDE6B MERTK	8.15e-05	33	75	3	DOID:8466 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	ZFHX4 C3 PLXNB2 MED13 ITPR2	2.24e-04	215	75	5	DOID:9970 (implicated_via_orthology)
Disease	parental longevity	GALNT15 C3P1 NEK5 LRRC4C ZW10 PLXNB2 HTT	2.63e-04	494	75	7	EFO_0007796
Disease	hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	4.88e-04	13	75	2	DOID:1459 (implicated_via_orthology)
Disease	systemic lupus erythematosus (is_implicated_in)	C3 C4A C4B	5.36e-04	62	75	3	DOID:9074 (is_implicated_in)
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	5.69e-04	14	75	2	DOID:0050328 (implicated_via_orthology)
Disease	renal cell carcinoma (is_implicated_in)	SLC49A4 C4A C4B	7.33e-04	69	75	3	DOID:4450 (is_implicated_in)
Disease	Antibody Deficiency Syndrome	C3 C4A	8.46e-04	17	75	2	C0003257
Disease	Retinitis pigmentosa	TTC8 PDE6B MERTK	8.98e-04	74	75	3	cv:C0035334
Disease	limited scleroderma	TTC8 TNPO3	1.06e-03	19	75	2	EFO_1001017
Disease	testosterone measurement	GALNT15 MSH6 C3P1 ARSJ ZFHX4 TTC28 SBF2 MYOCD PRKCQ GFRA2	1.41e-03	1275	75	10	EFO_0004908
Disease	Immunologic Deficiency Syndromes	C3 C4A	1.56e-03	23	75	2	C0021051
Disease	Etat Marbre	ATXN7 HTT	1.56e-03	23	75	2	C0266487
Disease	Disorder of eye	TTC8 PDE6C PDE6B MERTK	2.11e-03	212	75	4	C0015397
Disease	Retinitis Pigmentosa	TTC8 PDE6B MERTK	2.39e-03	104	75	3	C0035334
Disease	Movement Disorders	ATXN7 HTT	2.48e-03	29	75	2	C0026650
Disease	longevity, healthspan, parental longevity	ZW10 HTT	2.48e-03	29	75	2	EFO_0004300, EFO_0007796, EFO_0009762

Protein segments in the cluster

Peptide	Gene	Start	Entry
LMRSFNRDRRIFCAI	EP400	1956	Q96L91
QDQAARKIMRFLRRC	CAMTA1	1636	Q9Y6Y1
NMRRLISELYVRDNC	COX18	151	Q8N8Q8
MCSEARLARRLRDAL	ANKLE1	1	Q8NAG6
ANQMRNFLVRASCRL	C4B	1661	P0C0L5
RDCQRLVALLSSRLM	BCL2L10	136	Q9HD36
GLRLISLNMNFCSRE	SMPD1	376	P17405
LDLQVLDTRMCNNSR	GZMM	166	P51124
NPMRFSCQRRTRFIS	C3	701	P01024
RSRLAQDFMAQCLRE	CEP170B	496	Q9Y4F5
MSLRAYTARCRLNRL	ASPM	751	Q8IZT6
RYQLNLFARMCLDRQ	ITPR2	731	Q14571
LFARMCLDRQYLAIN	ITPR2	736	Q14571
RRCRSVELDLNQAHM	MELK	501	Q14680
KTQERNRCAMLFRQL	ANAPC5	726	Q9UJX4
FIRMLRSFIEISNNC	DUOX1	876	Q9NRD9
NRSLFLITLERCFQM	OTOA	156	Q7RTW8
ALAMIESTQQARCLR	PRKCQ	291	Q04759
RANRLCREAMRLQAG	NCDN	696	Q9UBB6
NRNFLHRDLAARNCM	MERTK	716	Q12866
FQRLSDACRALESLM	SBF2	231	Q86WG5
MRCLQFNETLTELRF	LMOD3	331	Q0VAK6
AAQFCMRDNTLLLRR	NAB2	326	Q15742
ININRRRYAAMLSCL	ARSJ	286	Q5FYB0
MAERLRYAINNCRSI	HERC1	4826	Q15751
MCRNLITFLRETFLN	DUOX2	1101	Q9NRD8
MERLQLQRRLGCRTF	GALNT15	471	Q8N3T1
CLDLRYLAMRQRNNL	EXD2	186	Q9NVH0
DCRAQRIAFNREQRM	MBD1	156	Q9UIS9
RNRTLLARMCREDPN	PLXNB2	241	O15031
LLQADRCSLFMYRQR	PDE6B	86	P35913
LQADRCSMFLCRSRN	PDE6C	91	P51160
ARVLNNSMELARTCI	NEK5	151	Q6P3R8
ERLCDAVAVLLNMRN	LSS	481	P48449
LSNLRYLNLAMCNLR	LRRC4C	196	Q9HCJ2
GLTADARLLCNFMRQ	PSMA1	76	P25786
MNQSLRLFREVCLAS	MSH6	1326	P52701
FDSRWNRLRCALNLM	ATXN7	536	O15265
RKARNRCNSADLVNM	MYOCD	66	Q8IZQ8
RRAFDSICPNRMLAL	MCIDAS	11	D6RGH6
CAQQAALPRLSRRMA	CBY2	71	Q8NA61
MCALRAENRAARRLG	HTRA4	126	P83105
LACRRVEMLLAANLQ	HTT	2011	P42858
NARSLLTDRSMAVRC	HEATR5B	181	Q9P2D3
QFQCSRLRESSRLMF	BABAM2	126	Q9NXR7
LCRQKNLMASIERAR	C3P1	276	Q6ZMU1
RALRCLDMLSLQGQF	CRHBP	56	P24387
RQCLAGRDRNTMLAN	GFRA2	61	O00451
RSVCRLLSNFRFLMI	SLC49A4	271	Q96SL1
GMATRVSNQNRFCRL	CCN5	211	O76076
ASLARNCMRLQVLEL	FBXO41	761	Q8TF61
ANQMRNFLVRASCRL	C4A	1661	P0C0L4
RLMTQRCKDRLNSLA	IHH	101	Q14623
RQALRRNTMLLCDAD	KBTBD12	231	Q3ZCT8
RDIDIILNRRNCMAA	NXF2	246	Q9GZY0
ARCRRHQRELMLANE	RHOXF1	156	Q8NHV9
VSFRMNCLNLLHFTR	FER1L5	581	A0AVI2
LDNRAARNHVNRMCL	UBA2	116	Q9UBT2
LASLRSVRAFCQEML	RDH14	116	Q9HBH5
QRLAEMCRSLRGAAR	SKIV2L	1201	Q15477
LLERCLMNRNFVRIG	MED13	126	Q9UHV7
RCQAMLLRKEALFRQ	SPTBN5	2656	Q9NRC6
RRCAINARNALTALF	CIZ1	846	Q9ULV3
IRAATMCNLCQRSFR	ZFHX4	1376	Q86UP3
RRRKFQLCADLCTQM	TTC8	16	Q8TAM2
RQDMRQLALRLASLF	MINPP1	151	Q9UNW1
QRDRARAMELCLALL	SLC39A1	201	Q9NY26
NRRFQLCRCMNPRAR	SPDYE16	246	A6NNV3
RTFAQAMRLCAARLT	SPIRE2	166	Q8WWL2
MAQLCGLRRSRAFLA	SPINT2	1	O43291
RCRRINRMLSNESLH	ARHGAP28	46	Q9P2N2
SIAQLSRQCRALLEM	SPTBN4	1676	Q9H254
ANGRCLLAALTMDNR	GTF3C4	176	Q9UKN8
LDHRDANCSVMRFLR	TNPO3	786	Q9Y5L0
AISCLERQLNIARDM	TTC28	976	Q96AY4
FLRMVRRNNLFNRSC	TTC28	1346	Q96AY4
LRLRACGLNFADLMA	VAT1	81	Q99536
GICFRLFSRLRFQNM	YTHDC2	746	Q9H6S0
AELQQFLRGARAMCI	PIGO	426	Q8TEQ8
AQRTLYRDVMLENCR	ZNF557	56	Q8N988
FRRLGTECFLAQMRA	ZW10	581	O43264