Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	collagen type IV trimer	COL4A2 COL4A4	6.17e-05	6	43	2	GO:0005587
GeneOntologyCellularComponent	basement membrane collagen trimer	COL4A2 COL4A4	1.15e-04	8	43	2	GO:0098651
GeneOntologyCellularComponent	network-forming collagen trimer	COL4A2 COL4A4	1.15e-04	8	43	2	GO:0098642
GeneOntologyCellularComponent	collagen network	COL4A2 COL4A4	1.15e-04	8	43	2	GO:0098645
GeneOntologyCellularComponent	endoplasmic reticulum lumen	FGA COL4A2 COL4A4 PCSK7 ADAMTS7	5.75e-04	332	43	5	GO:0005788
GeneOntologyCellularComponent	complex of collagen trimers	COL4A2 COL4A4	8.47e-04	21	43	2	GO:0098644
Domain	TF_POU_3	POU3F1 POU3F2	3.10e-05	4	43	2	IPR016362
Domain	C4	COL4A2 COL4A4	7.72e-05	6	43	2	SM00111
Domain	-	COL4A2 COL4A4	7.72e-05	6	43	2	2.170.240.10
Domain	Collagen_VI_NC	COL4A2 COL4A4	7.72e-05	6	43	2	IPR001442
Domain	NC1_IV	COL4A2 COL4A4	7.72e-05	6	43	2	PS51403
Domain	C4	COL4A2 COL4A4	7.72e-05	6	43	2	PF01413
Domain	POU	POU3F1 POU3F2	6.09e-04	16	43	2	SM00352
Domain	POU_2	POU3F1 POU3F2	6.09e-04	16	43	2	PS00465
Domain	Pou	POU3F1 POU3F2	6.09e-04	16	43	2	PF00157
Domain	POU_dom	POU3F1 POU3F2	6.09e-04	16	43	2	IPR000327
Domain	POU_3	POU3F1 POU3F2	6.09e-04	16	43	2	PS51179
Domain	POU_1	POU3F1 POU3F2	6.09e-04	16	43	2	PS00035
Domain	POU	POU3F1 POU3F2	6.89e-04	17	43	2	IPR013847
Domain	-	POU3F1 POU3F2	1.75e-03	27	43	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU3F1 POU3F2	2.02e-03	29	43	2	IPR010982
Pathway	BIOCARTA_AMI_PATHWAY	FGA COL4A2 COL4A4	7.82e-06	20	28	3	M15394
Pathway	BIOCARTA_INTRINSIC_PATHWAY	FGA COL4A2 COL4A4	1.21e-05	23	28	3	M15997
Pathway	BIOCARTA_INTRINSIC_PATHWAY	FGA COL4A2 COL4A4	1.21e-05	23	28	3	MM1427
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A2 COL4A4 CACNA1H	7.65e-05	42	28	3	M7169
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A2 COL4A4	1.70e-04	10	28	2	M22040
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A2 COL4A4	1.70e-04	10	28	2	MM1560
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A2 COL4A4	2.07e-04	11	28	2	M15422
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A2 COL4A4	2.48e-04	12	28	2	MM1526
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAP3K10 MAP3K12	2.48e-04	12	28	2	M47929
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL4A2 COL4A4 CACNA1H	2.57e-04	63	28	3	M11187
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A2 COL4A4	2.93e-04	13	28	2	MM1347
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A2 COL4A4	2.93e-04	13	28	2	M12950
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A2 COL4A4	3.41e-04	14	28	2	MM1458
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A2 COL4A4	3.41e-04	14	28	2	M6487
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	COL4A2 COL4A4	3.93e-04	15	28	2	M27161
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A2 COL4A4	3.93e-04	15	28	2	MM14922
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	FGA COL4A2 COL4A4	4.48e-04	76	28	3	MM14867
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A2 COL4A4	5.71e-04	18	28	2	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A2 COL4A4	5.71e-04	18	28	2	MM14882
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	FGA COL4A2 COL4A4	6.22e-04	85	28	3	M16441
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A2 COL4A4	7.07e-04	20	28	2	MM15061
Pathway	REACTOME_EGR2_AND_SOX10_MEDIATED_INITIATION_OF_SCHWANN_CELL_MYELINATION	POU3F1 POU3F2	1.49e-03	29	28	2	M29808
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A2 COL4A4	1.60e-03	30	28	2	M27216
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL4A2 COL4A4	1.82e-03	32	28	2	MM14924
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL4A2 COL4A4	2.56e-03	38	28	2	MM14969
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A2 COL4A4	2.97e-03	41	28	2	MM15538
Pathway	PID_INTEGRIN3_PATHWAY	FGA COL4A4	3.27e-03	43	28	2	M53
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A2 COL4A4	3.42e-03	44	28	2	M27812
Pubmed	Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.	MAP3K10 SH3RF1 MAP3K12	1.69e-07	9	45	3	14504284
Pubmed	Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.	FGA COL4A2 COL4A4	7.29e-07	14	45	3	12878203
Pubmed	FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.	FBXO24 FOXK2	1.64e-06	2	45	2	38735474
Pubmed	Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly.	COL4A2 COL4A4	1.64e-06	2	45	2	30443360
Pubmed	Collagen types in various layers of the human aorta and their changes with the atherosclerotic process.	COL4A2 COL4A4	4.91e-06	3	45	2	3089234
Pubmed	Nature and the multiple functions of the 67-kD elastin-/laminin binding protein.	COL4A2 COL4A4	9.81e-06	4	45	2	7827955
Pubmed	Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.	POU3F1 POU3F2	9.81e-06	4	45	2	22566684
Pubmed	A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells.	POU3F1 POU3F2	9.81e-06	4	45	2	15893976
Pubmed	Structure and evolution of four POU domain genes expressed in mouse brain.	POU3F1 POU3F2	9.81e-06	4	45	2	1565620
Pubmed	Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.	POU3F1 POU3F2	9.81e-06	4	45	2	26265007
Pubmed	In vitro interactions of oxidatively modified LDL with type I, II, III, IV, and V collagen, laminin, fibronectin, and poly-D-lysine.	COL4A2 COL4A4	1.63e-05	5	45	2	9409248
Pubmed	The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.	POU3F1 POU3F2	1.63e-05	5	45	2	9105675
Pubmed	Cooperative function of POU proteins and SOX proteins in glial cells.	POU3F1 POU3F2	1.63e-05	5	45	2	9632656
Pubmed	The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.	POU3F1 POU3F2	1.63e-05	5	45	2	12782656
Pubmed	Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.	COL4A2 COL4A4	2.45e-05	6	45	2	10534397
Pubmed	Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.	POU3F1 POU3F2	2.45e-05	6	45	2	18505825
Pubmed	Stimulation of extracellular matrix components in the normal brain by invading glioma cells.	COL4A2 COL4A4	2.45e-05	6	45	2	9506531
Pubmed	The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.	POU3F1 POU3F2	2.45e-05	6	45	2	21185279
Pubmed	HIV-1 gp160 protein-macrophage interactions modulate mesangial cell proliferation and matrix synthesis.	COL4A2 COL4A4	2.45e-05	6	45	2	7495302
Pubmed	A tumor derived motility factor that stimulates cell migration on extracellular matrix.	COL4A2 COL4A4	2.45e-05	6	45	2	9673377
Pubmed	Extracellular matrix of the human optic nerve head.	COL4A2 COL4A4	2.45e-05	6	45	2	2426947
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU3F1 POU3F2	2.45e-05	6	45	2	2739723
Pubmed	Angiogenesis and collagen type IV expression in different endothelial cell culture systems.	COL4A2 COL4A4	2.45e-05	6	45	2	23551189
Pubmed	Monoclonal antibody to human basement membrane collagen type IV.	COL4A2 COL4A4	2.45e-05	6	45	2	6811420
Pubmed	Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development.	COL4A2 COL4A4	2.45e-05	6	45	2	11732842
Pubmed	Developmental distribution of collagen IV isoforms and relevance to ocular diseases.	COL4A2 COL4A4	2.45e-05	6	45	2	19275937
Pubmed	Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.	COL4A2 COL4A4	2.45e-05	6	45	2	6988303
Pubmed	Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.	COL4A2 COL4A4	2.45e-05	6	45	2	6389236
Pubmed	Collagen IV in the developing lens capsule.	COL4A2 COL4A4	2.45e-05	6	45	2	12225806
Pubmed	Nidogen-1. Expression and ultrastructural localization during the onset of mesoderm formation in the early mouse embryo.	COL4A2 COL4A4	3.42e-05	7	45	2	10639489
Pubmed	Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.	COL4A2 COL4A4	3.42e-05	7	45	2	7521231
Pubmed	Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.	COL4A2 COL4A4	3.42e-05	7	45	2	11711546
Pubmed	Regulation of protease nexin-1 target protease specificity by collagen type IV.	COL4A2 COL4A4	3.42e-05	7	45	2	8006028
Pubmed	Corneal cell proteins and ocular surface pathology.	COL4A2 COL4A4	3.42e-05	7	45	2	10416788
Pubmed	Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.	POU3F1 POU3F2	3.42e-05	7	45	2	17301088
Pubmed	Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).	COL4A2 COL4A4	3.42e-05	7	45	2	10716744
Pubmed	Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.	COL4A2 COL4A4	3.42e-05	7	45	2	1724753
Pubmed	Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and Is Required for the Early Phase of Neurogenesis.	VGLL2 NEUROG3	4.56e-05	8	45	2	32273485
Pubmed	Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.	COL4A2 COL4A4	4.56e-05	8	45	2	10382266
Pubmed	Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.	COL4A2 COL4A4	4.56e-05	8	45	2	11683410
Pubmed	Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.	COL4A2 COL4A4	4.56e-05	8	45	2	3997552
Pubmed	The JIP group of mitogen-activated protein kinase scaffold proteins.	MAP3K10 MAP3K12	4.56e-05	8	45	2	10490659
Pubmed	Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.	COL4A2 COL4A4	4.56e-05	8	45	2	29422532
Pubmed	The Transcription Factor Pou3f1 Sheds Light on the Development and Molecular Diversity of Glutamatergic Cerebellar Nuclear Neurons in the Mouse.	POU3F1 POU3F2	4.56e-05	8	45	2	35935334
Pubmed	Molecular properties of wild-type and mutant betaIG-H3 proteins.	COL4A2 COL4A4	4.56e-05	8	45	2	11867580
Pubmed	MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues.	COL4A2 ADAMTS7	5.86e-05	9	45	2	27515006
Pubmed	MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation?	COL4A2 COL4A4	5.86e-05	9	45	2	9878537
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F1 POU3F2	5.86e-05	9	45	2	15872005
Pubmed	Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis.	COL4A2 COL4A4	5.86e-05	9	45	2	8562707
Pubmed	Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.	COL4A2 COL4A4	5.86e-05	9	45	2	12101409
Pubmed	Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.	COL4A2 COL4A4	5.86e-05	9	45	2	10880400
Pubmed	Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A.	COL4A2 COL4A4	5.86e-05	9	45	2	8995276
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	MMRN1 FGA COL4A2 COL4A4	6.55e-05	167	45	4	22159717
Pubmed	Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.	COL4A2 COL4A4	7.32e-05	10	45	2	9136074
Pubmed	Distribution of fibronectin, type I collagen, type IV collagen, and laminin in the cardiac jelly of the mouse embryonic heart with retinoic acid-induced complete transposition of the great arteries.	COL4A2 COL4A4	7.32e-05	10	45	2	9415455
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	MMRN1 FGA COL4A2 COL4A4	7.86e-05	175	45	4	28071719
Pubmed	Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development.	COL4A2 COL4A4	8.94e-05	11	45	2	14998921
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	COL4A2 COL4A4	8.94e-05	11	45	2	7500359
Pubmed	Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3.	COL4A2 COL4A4	8.94e-05	11	45	2	9731539
Pubmed	Murine chromosomal location of four class III POU transcription factors.	POU3F1 POU3F2	1.07e-04	12	45	2	8276397
Pubmed	Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice.	COL4A2 COL4A4	1.07e-04	12	45	2	8918877
Pubmed	Basement membrane fragility underlies embryonic lethality in fukutin-null mice.	COL4A2 COL4A4	1.07e-04	12	45	2	15837576
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	COL4A2 COL4A4	1.07e-04	12	45	2	12180907
Pubmed	Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.	COL4A2 COL4A4	1.07e-04	12	45	2	16024816
Pubmed	Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice.	POU3F1 PHOX2B	1.07e-04	12	45	2	38830761
Pubmed	SoxE proteins are differentially required in mouse adrenal gland development.	POU3F1 PHOX2B	1.07e-04	12	45	2	18272785
Pubmed	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.	POU3F1 POU3F2	1.27e-04	13	45	2	8543156
Pubmed	Basal lamina molecules are concentrated in myogenic regions of the mouse limb bud.	COL4A2 COL4A4	1.27e-04	13	45	2	9833687
Pubmed	GIGYF1 disruption associates with autism and impaired IGF-1R signaling.	POU3F2 GIGYF1	1.27e-04	13	45	2	35917186
Pubmed	Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.	PHOX2B NEUROG3	1.47e-04	14	45	2	27923395
Pubmed	Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve.	PHOX2B NEUROG3	1.47e-04	14	45	2	12571110
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU3F1 POU3F2	1.47e-04	14	45	2	17141158
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	POU3F1 POU3F2	1.47e-04	14	45	2	15273690
Pubmed	Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract.	COL4A2 COL4A4	1.47e-04	14	45	2	19858219
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	COL4A2 COL4A4	1.70e-04	15	45	2	10625553
Pubmed	MAP3Ks as central regulators of cell fate during development.	MAP3K10 MAP3K12	1.70e-04	15	45	2	18855897
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	POU3F1 POU3F2	1.70e-04	15	45	2	18255031
Pubmed	MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.	TAP1 IL21R	1.70e-04	15	45	2	21964024
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	COL4A2 COL4A4	1.70e-04	15	45	2	9264260
Pubmed	Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos.	COL4A2 COL4A4	1.70e-04	15	45	2	10706142
Pubmed	Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression.	POU3F1 PHOX2B	1.70e-04	15	45	2	20144603
Pubmed	The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.	POU3F1 POU3F2	1.94e-04	16	45	2	9118797
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	POU3F1 POU3F2	1.94e-04	16	45	2	19527706
Pubmed	Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.	POU3F1 PHOX2B	1.94e-04	16	45	2	17699610
Pubmed	Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.	PHOX2B NEUROG3	1.94e-04	16	45	2	10217145
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	COL4A2 COL4A4	1.94e-04	16	45	2	15878328
Pubmed	Ascl1 is required to specify a subset of ventromedial hypothalamic neurons.	VGLL2 NEUROG3	2.20e-04	17	45	2	32253239
Pubmed	Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions.	SH3RF1 MAP3K12	2.20e-04	17	45	2	32659913
Pubmed	Signals from the neural crest regulate beta-cell mass in the pancreas.	PHOX2B NEUROG3	2.47e-04	18	45	2	18506029
Pubmed	Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation.	COL4A2 COL4A4	2.47e-04	18	45	2	9160753
Pubmed	Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence.	POU3F1 PHOX2B	2.47e-04	18	45	2	16790476
Pubmed	PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.	POU3F1 POU3F2	2.76e-04	19	45	2	33597191
Pubmed	Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.	COL4A2 COL4A4	2.76e-04	19	45	2	15689378
Pubmed	Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.	POU3F1 NEUROG3	3.06e-04	20	45	2	19501159
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	POU3F1 POU3F2	3.06e-04	20	45	2	11859196
Pubmed	Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.	POU3F1 POU3F2	3.38e-04	21	45	2	28880149
Pubmed	GDNF is required for neural colonization of the pancreas.	PHOX2B NEUROG3	3.38e-04	21	45	2	23903190
Pubmed	Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.	DISP2 NEUROG3	3.38e-04	21	45	2	20003319
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	COL4A2 COL4A4	3.38e-04	21	45	2	27856617
Pubmed	βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.	DISP2 NEUROG3	3.72e-04	22	45	2	26944677
GeneFamily	POU class homeoboxes and pseudogenes	POU3F1 POU3F2	7.98e-04	23	33	2	523
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K10 MAP3K12	8.70e-04	24	33	2	654
GeneFamily	Collagens	COL4A2 COL4A4	3.18e-03	46	33	2	490
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FGA COL4A4 ADAMTS7 PDE11A	5.96e-06	117	45	4	0602bbad908cb28c5093b74d717da5f2af577943
ToppCell	AT1-AT2_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	FGA COL4A2 COL4A4 MTCL1	1.81e-05	155	45	4	010e45ef4b505bf419ea41e4d1619521d1c78319
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	COL4A4 MYO18B PANK1 NEUROG3	1.81e-05	155	45	4	83430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCell	356C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ALPK3 MMRN1 FBXO24 LY86	2.00e-05	159	45	4	299e2162a82e31196d7f3a110c2db622349edfff
ToppCell	356C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ALPK3 MMRN1 FBXO24 LY86	2.00e-05	159	45	4	0a3a363b30a8c741e1a3e2525725108d03c21776
Disease	Left ventricular mass to end-diastolic volume ratio	ALPK3 MYO18B	5.81e-04	25	42	2	EFO_0010556
Disease	Large cell carcinoma of lung	ALPK3 MYO18B	9.55e-04	32	42	2	C0345958
Disease	acute lymphoblastic leukemia (is_marker_for)	FGA KDM3B	1.08e-03	34	42	2	DOID:9952 (is_marker_for)
Disease	Metastatic melanoma	ALPK3 MAP3K10	2.70e-03	54	42	2	C0278883
Disease	Small cell carcinoma of lung	COL4A2 MYO18B	2.70e-03	54	42	2	C0149925
Disease	non-lobar intracerebral hemorrhage	COL4A2 MYO18B	3.66e-03	63	42	2	EFO_0010178

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEWGPRGGPSGAGGS	CCDC85B	146	Q15834
GSGLGAGPGAGTWAP	ALPK3	116	Q96L96
GLPGSWGAGGPAGPT	COL4A4	196	P53420
TPGTKGWAGDSGPQG	COL4A2	1321	P08572
LSWKGRGGPGDGSPV	DISP2	1361	A7MBM2
WPGAGDQTGGGSRPG	ARMCX4	1586	Q5H9R4
WPLGTLGPEGSGSGS	ADAMTS7	996	Q9UKP4
AARWGPGPGGAGGAP	ISLR2	506	Q6UXK2
EPGWLGEGASPGAGG	MTCL1	676	Q9Y4B5
SKWGDRPVGGGPSAG	FASTK	66	Q14296
GPSSGAGPGFGPGSW	LRCH3	31	Q96II8
SSGGSGTWSRGGPPK	MAP3K10	531	Q02779
AGPLWGGPDKSGGGS	GIGYF1	821	O75420
CGELGSPGGSPGDWG	NEUROG3	156	Q9Y4Z2
PSCSGGGGGKAWPTH	LY86	16	O95711
GGGGSPPGGWAVARL	FOXK2	26	Q01167
VPGGKGPCGWTGGSC	MMRN1	231	Q13201
TGGPDGQGTGGPSWA	PCSK7	41	Q16549
SSSSAKGGGAPWPGG	MTSS2	281	Q765P7
GDCGGVPLSPSWAGG	PDE11A	91	Q9HCR9
PQWLPTGGGGGGDWA	POU3F1	71	Q03052
RGPWKGGNASGEPGL	KDM3B	321	Q7LBC6
EKAWPGPHGTTGEGG	NUTM1	176	Q86Y26
SPGGLGGGPSAWEAC	MAP3K12	576	Q12852
GCGAGGRLPGWPKGS	FBXO24	436	O75426
GGTATWKPGSSGPGS	FGA	316	P02671
GGLPWGGRSPGGVSE	IL21R	461	Q9HBE5
WAGGPPGTGGHGPLS	CACNA1H	636	O95180
PGTDGWGLPSGGGGA	HS3ST4	121	Q9Y661
VTSWGDGCGEPGKPG	PRSS56	306	P0CW18
GGGSPGWGCAGIPDS	PANK1	41	Q8TE04
KLGSLWVPGGQGGSG	TAP1	156	Q03518
THPDALKGGGGWGWG	RUSC1-AS1	56	Q66K80
GGGDGSPWSTSPLGQ	POU3F2	86	P20265
SPWPGSGGLAGSEGT	SLX4	626	Q8IY92
WKPGPGGGSGTNCTN	SH3RF1	81	Q7Z6J0
GKGEPAGAAWAGPGG	VGLL2	271	Q8N8G2
GPGPGPGTGWGGTAA	SYT15B	46	X6R8R1
GPGAEGGGSWKGRPF	ZNF696	111	Q9H7X3
ETAGGGPSEGPGGWP	SERPINE3	161	A8MV23
GGTAGPGTGGLPRWQ	TOMM70	26	O94826
PWGGPGAGKMAAAAG	PPP1R3F	56	Q6ZSY5
APGKGGWPGSRGQEA	MYO18B	431	Q8IUG5
KGLKGGGGGPGGWTC	ZNF687	951	Q8N1G0
GGLAAAGGPGQGWAP	PHOX2B	261	Q99453